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https://www.readbyqxmd.com/read/28240001/polycystic-ovary-syndrome-pcos-diagnostic-criteria-and-amh
#1
Majid Bani Mohammad, Abbas Majdi Seghinsara
The polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility and a notable proportion of women of reproductive age are affected. It may constitute a risk factor for cancer development. Different factors could result in different manifestations and many of these are related to predispositions. It is essential to establish criteria to achieve an exact diagnosis of PCOS, especially among adolescent patients because of the overlap between features of PCO syndrome and physiological findings in puberty...
1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28239988/novel-serotype-of-bluetongue-virus-in-south-america-and-first-report-of-epizootic-haemorrhagic-disease-virus-in-ecuador
#2
J Verdezoto, E Breard, C Viarouge, H Quenault, P Lucas, C Sailleau, S Zientara, D Augot, S Zapata
Bluetongue virus (BTV) and Epizootic haemorrhagic disease virus (EHDV) are closely related Orbiviruses that affect domestic and wild ruminants. In Ecuador previous serological studies reported the presence of BTV; however, no data are available about the presence of EHDV. In this study, 295 cattle without symptoms of infection were sampled from two farms located in Andean and Amazonian regions and from a slaughterhouse in the coastal region. ELISA analyses showed high prevalence of BTV (98.9%) and EHDV (81...
February 26, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28239972/influence-of-mobile-phase-source-parameters-and-source-type-on-electrospray-ionization-efficiency-in-negative-ion-mode
#3
Anneli Kruve
Electrospray ionization (ESI) efficiency is known to be affected by the properties of the analytes, source design and source parameters. In this study, the ionization efficiency of 17 acidic compounds at various conditions in ESI negative ion mode was evaluated. Namely, the influence of organic solvent content in the mobile phase, ionization source parameters, ionization source geometry and functionality (conventional ESI, ESI with thermal focussing and with additional internal nebulizer gas) was studied. It was observed that the ionization efficiency in thermal focussing ESI is only marginally affected by the organic solvent composition, while for conventional ESI and ESI with internal nebulizer gas, the ionization efficiency increases significantly with increasing organic modifier content...
August 2016: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28239958/differential-sex-effects-of-systolic-blood-pressure-and-ldl-c-on-type-2-diabetes-life-course-data-from-the-bogalusa-heart-study
#4
Benjamin D Pollock, Wei Chen, Emily W Harville, Tian Shu, Vivian Fonseca, Franck Mauvais-Jarvis, Tanika N Kelly, Lydia A Bazzano
BACKGROUND: There may be sex-specific cardiometabolic mechanisms early in life that affect the development of type 2 diabetes (T2DM) through mid-adulthood. Yet, there have been few studies examining whether early life-course interactions between cardiometabolic risk factors and sex are associated with incident T2DM. METHODS: We followed n = 7,725 children from the Bogalusa Heart Study through mid-adulthood to examine whether low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), body mass index (BMI), or systolic blood pressure (SBP) differentially impact the risk of T2DM for females versus males...
February 27, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28239953/depression-anxiety-and-health-related-quality-of-life-amongst-patients-who-are-starting-dialysis-treatment
#5
Ana Rebollo Rubio, José Miguel Morales Asencio, Ma Eugenia Pons Raventos
BACKGROUND: Chronic kidney disease (CKD) has a severe impact on patients' health-related quality of life (HRQL). The start of renal replacement therapy (RRT) significantly influences psychological, physical and social aspects of life. OBJECTIVES: To analyse the HRQL and psychological status (anxiety and depression) at the start of RRT. METHODS: We undertook an observational descriptive cross-sectional study. A total of 152 patients starting RRT were recruited for the study...
February 27, 2017: Journal of Renal Care
https://www.readbyqxmd.com/read/28239948/burnout-depression-and-suicidal-ideation-in-dental-and-dental-hygiene-students
#6
George R Deeb, Sarah Braun, Caroline Carrico, Patricia Kinser, Daniel Laskin, Janina Golob Deeb
INTRODUCTION: The aim of this study was to assess the relationship between burnout, depressive symptoms and suicidal ideation in dental and dental hygiene students and to evaluate the influence of gender, programme type and year of study. SUBJECTS AND METHODS: Third- and fourth-year dental (DS) and first- and second-year hygiene students (DHS) completed the Patient Health Questionnaire (PHQ-9) and an abbreviated Maslach Burnout Inventory online as measures of depressive symptoms/suicidality and burnout, respectively...
February 27, 2017: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/28239881/how-chronic-disease-affects-children-s-views-on-being-ill-and-healthy-a-comparative-study
#7
Lígia Lima, Vanessa Silva, Marina S Lemos
BACKGROUND: Understanding children's views of illness and health is vital to a child-centred approach in patient education and care. Paediatric healthcare providers should incorporate children's views of health and illness to enable children and their families to participate in self-management plans and achieve better health outcomes. However, there is limited scientific knowledge regarding the views of children with specific diseases. METHOD: This comparative study investigated whether and in what ways the experience of having different chronic diseases influenced children's views of being ill and healthy...
February 26, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28239870/genotype-by-environment-effect-on-bioactive-compounds-in-strawberry-fragaria-x-ananassa-duch
#8
Luisa Palmieri, Domenico Masuero, Paolo Martinatti, Giuseppe Baratto, Stefan Martens, Urska Vrhovsek
BACKGROUND: The relative contribute assessment of the genotype, the environment and the genotype-by-environmental (G x E) interaction to the variety performance is necessary to determine their adaptation capacity. RESULTS: The influence of temperature, UV-irradiation and sunshine duration on quality and fruits composition was investigated in nine strawberry cultivars grown at three different altitudes. The UV-radiation intensity affected the pH and the sugar content that were higher for most of the varieties at low altitudes where the total titratable acidity (TTA) was less...
February 27, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28239855/immune-priming-specificity-within-and-across-generations-reveals-the-range-of-pathogens-affecting-evolution-of-immunity-in-an-insect
#9
Julien Dhinaut, Manon Chogne, Yannick Moret
1.Many organisms can improve their immune response as a function of their immunological experience or that of their parents. This phenomenon, called immune priming, has likely evolved from repetitive challenges by the same pathogens during the host lifetime or across generation. 2.All pathogens may not expose host to the same probability of re-infection and immune priming is expected to evolve from pathogens exposing the host to the greatest probability of re-infection. Under this hypothesis, the priming response to these pathogens should be specifically more efficient and less costly than to others...
February 27, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28239848/protein-phosphatase-2a-pp2a-regulation-of-markers-of-extracellular-matrix-remodelling-in-hcc-cells-functional-consequences-for-tumour-invasion
#10
M P Ward, J P Spiers
BACKGROUND AND PURPOSE: A hallmark of tumour invasion is breakdown of the extracellular matrix as a consequence of dysregulation of the MMP system. While our understanding of how this is regulated by kinase signalling pathways is well established, its counter-regulation by protein phosphatases is less well known. Therefore, we investigated the effect of inhibition of protein phosphatases on markers of extracellular remodelling and how PP2A modulates MMP-9 abundance and function of Hep3B cells...
February 27, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28239807/adiponectin-partially-rescues-high-glucose-high-fat-induced-impairment-of-mitochondrial-biogenesis-and-function-in-a-pgc-1%C3%AE-dependent-manner
#11
H Wang, W-J Yan, J-L Zhang, F-Y Zhang, C Gao, Y-J Wang, W Bond Law, L Tao
OBJECTIVE: Plasma adiponectin (APN) levels are decreased in diabetic patients. Dysfunctional mitochondrial biogenesis is involved in type 2 diabetes (T2DM) pathogenesis, by unclear mechanisms. The present study determined (1) whether myocardial mitochondrial biogenesis was impaired in cardiomyocytes exposed to a high glucose/high fat (HGHF) medium (a T2DM in vitro model), (2) the effects of APN administration upon mitochondrial biogenesis in cardiomyocytes affected by HGHF incubation, and 3) the involved underlying mechanisms...
January 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239803/nasal-hppsis-administration-enhances-ngf-and-tumor-suppressor-protein-p73-in-human-brain-cancer-tissues-preliminary-data
#12
L Aloe, M L Rocco, E Stigliano, F Angelini, M Iacoangeli, V Frari, F Salvinelli
OBJECTIVE: Nerve Growth Factor (NGF) is a neurotrophic factor known to play a critical role in growth, survival, differentiation and neuroprotection of peripheral sensory and sympathetic neurons, as well as brain neurons. We have recently reported that nasal administration of high-pressure isotonic physiological saline solution (HPpSIS) enhances the level of NGF and the expression of NGF receptors in neurons of the olfactory bulbs and forebrain cholinergic neurons of laboratory animals...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239802/anesthetic-management-of-patients-with-dilated-cardiomyopathy-for-noncardiac-surgery
#13
C-Q Chen, X Wang, J Zhang, S-M Zhu
Anesthetic management of patients with dilated cardiomyopathy (DCM) is a challenge to the anesthesiologist, due to poor left systolic function, ventricular enlargement, risk of malignant arrhythmias and sudden cardiac death. Therefore, preoperative assessment and appropriate anesthetic management are important in patients with DCM. This review describes the preoperative evaluation and anesthesia considerations of patients with DCM undergoing non-cardiac surgery. Patient pathophysiology and clinical status, such as ventricular function, degree of myocardial fibrosis, resting heart rate and high-sensitivity C-reactive protein can affect survival rates...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239785/pharmacological-analysis-of-the-therapeutic-effect-of-radioprotectors-cystamine-and-indralin-in-the-capacity-of-radiomitigators
#14
M V Vasin, I B Ushakov, V Yu Kovtun, S N Komarova, L A Semenova, A A Galkin, R V Afanas'ev, I V Bukhtiyarov
The therapeutic radiomitigating effect of cystamine and indralin was studied in experiments on mice and rats and pharmacological analysis of these drugs was carried out. The animals were subjected to whole-body (60)Co γ-irradiation. The mice were exposed to single (9-10 Gy) or double (8 Gy) irradiation with an interval of 1 month. The rats were exposed to 10 Gy with partial shielding of the upper quarter of the abdomen. In experiments on mice, pretreatment with reserpine abolished the therapeutic effect of cystamine administered repeatedly every 15 min over 1 h after irradiation...
February 27, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28239783/effect-of-thp-1-cells-on-the-formation-of-vascular-tubes-by-endothelial-ea-hy926-cells-in-the-presence-of-placenta-secretory-products
#15
T Yu Lvova, K L Belyakova, S A Sel'kov, D I Sokolov
We studied the effect of THP-1 cells on the formation of vessel-like structures by endothelial cells in the presence of placenta-conditioned media. Addition of THP-1 cells to endothelial cells cultured in the presence of media conditioned by first-trimester placentas led to an increase in the length of cell tubes and reduced their number in comparison with endothelial cell monoculture. In the presence of media conditioned by third-trimester placentas, THP-1 cells did not affect the length and number of cell tubes formed by endothelial cells...
February 27, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28239667/disregard-of-neurological-impairments-associated-with-neglected-tropical-diseases-in-africa
#16
Emmanuel Quansah, Esther Sarpong, Thomas K Karikari
Neglected tropical diseases (NTDs) affect people in the bottom billion poorest in the world. These diseases are concentrated in rural areas, conflict zones and urban slums in Africa and other tropical areas. While the World Health Organization recognizes seventeen priority NTDs, the list of conditions present in Africa and elsewhere that are eligible to be classified as NTDs is much longer. Although NTDs are generally marginalized, their associated neurological burden has been almost completely disregarded...
June 2016: ENeurologicalSci
https://www.readbyqxmd.com/read/28239661/klf2-and-klf4-control-endothelial-identity-and-vascular-integrity
#17
Panjamaporn Sangwung, Guangjin Zhou, Lalitha Nayak, E Ricky Chan, Sandeep Kumar, Dong-Won Kang, Rongli Zhang, Xudong Liao, Yuan Lu, Keiki Sugi, Hisashi Fujioka, Hong Shi, Stephanie D Lapping, Chandra C Ghosh, Sarah J Higgins, Samir M Parikh, Hanjoong Jo, Mukesh K Jain
Maintenance of vascular integrity in the adult animal is needed for survival, and it is critically dependent on the endothelial lining, which controls barrier function, blood fluidity, and flow dynamics. However, nodal regulators that coordinate endothelial identity and function in the adult animal remain poorly characterized. Here, we show that endothelial KLF2 and KLF4 control a large segment of the endothelial transcriptome, thereby affecting virtually all key endothelial functions. Inducible endothelial-specific deletion of Klf2 and/or Klf4 reveals that a single allele of either gene is sufficient for survival, but absence of both (EC-DKO) results in acute death from myocardial infarction, heart failure, and stroke...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28239648/liver-x-receptor-%C3%AE-mediates-hepatic-triglyceride-accumulation-through-upregulation-of-g0-g1-switch-gene-2-expression
#18
Bradlee L Heckmann, Xiaodong Zhang, Alicia M Saarinen, Gabriele Schoiswohl, Erin E Kershaw, Rudolf Zechner, Jun Liu
Liver X receptors (LXRs) are transcription factors essential for cholesterol homeostasis and lipogenesis. LXRα has been implicated in regulating hepatic triglyceride (TG) accumulation upon both influx of adipose-derived fatty acids (FAs) during fasting and stimulation of de novo FA synthesis by chemical agonism of LXR. However, whether or not a convergent mechanism is employed to drive deposition of FAs from these 2 different sources in TGs is undetermined. Here, we report that the G0/G1 Switch Gene 2 (G0S2), a selective inhibitor of intracellular TG hydrolysis/lipolysis, is a direct target gene of LXRα...
February 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28239631/early-adverse-life-events-are-associated-with-altered-brain-network-architecture-in-a-sex-dependent-manner
#19
Arpana Gupta, Emeran A Mayer, Jonathan R Acosta, Kareem Hamadani, Carinna Torgerson, John D van Horn, Lin Chang, Bruce Naliboff, Kirsten Tillisch, Jennifer S Labus
INTRODUCTION: Early adverse life events (EALs) increase the risk for chronic medical and psychiatric disorders by altering early neurodevelopment. The aim of this study was to examine associations between EALs and network properties of core brain regions in the emotion regulation and salience networks, and to test the influence of sex on these associations. METHODS: Resting-state functional and diffusion tensor magnetic resonance imaging were obtained in healthy individuals (61 men, 63 women)...
December 2017: Neurobiology of Stress
https://www.readbyqxmd.com/read/28239598/general-self-efficacy-and-diabetes-management-self-efficacy-of-diabetic-patients-referred-to-diabetes-clinic-of-aq-qala-north-of-iran
#20
Hajar Dehghan, Abdurrahman Charkazi, Ghorban Mohammad Kouchaki, Bagher Pahlevan Zadeh, Bibi Azizieh Dehghan, Mohammad Matlabi, Morteza Mansourian, Mostafa Qorbani, Omid Safari, Tahereh Pashaei, Babak Rastegari Mehr
BACKGROUND: Self-efficacy is one of the factors involved in successful self-care of diabetic patients. The aim of this study was to evaluate general self-efficacy and diabetes management self-efficacy and to determine their association with glycemic control in diabetic individuals, referred to the diabetes clinic of Aq Qala city, North of Iran. METHODS: In this cross-sectional study, 251 type 2 diabetes mellitus patients were enrolled using census method. Data collection tools consisted of Sherer General Self-Efficacy Scale (SGSES) and Diabetes Management Self-Efficacy Scale (DMSES) with minor demographic adjustments and hemoglobin A1C test...
2017: Journal of Diabetes and Metabolic Disorders
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