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https://www.readbyqxmd.com/read/29108477/hyperthermia-and-mild-traumatic-brain-injury-effects-on-inflammation-and-the-cerebral-vasculature
#1
Jessie Truettner, Helen M Bramlett, W Dalton Dietrich
Mild traumatic brain injury (mTBI) or concussion represents the majority of TBIs brain trauma in the United States. The pathophysiology of mTBI is complex and may include both focal and diffuse injury patterns. In addition to altered circuit dysfunction and diffuse traumatic axonal injury (DTAI), chronic neuroinflammation has also been implicated in the pathophysiology of mTBI. Recently, our laboratory has reported the detrimental effects of mild hyperthermic mTBI in terms of worsening histopathological and behavioral outcomes...
November 6, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29097755/lasting-deficit-in-inhibitory-control-with-mild-traumatic-brain-injury
#2
Benjamin Xu, Marco Sandrini, Sarah Levy, Rita Volochayev, Oluwole Awosika, John A Butman, Dzung L Pham, Leonardo G Cohen
Being able to focus on a complex task and inhibit unwanted actions or interfering information (i.e., inhibitory control) are essential human cognitive abilities. However, it remains unknown the extent to which mild traumatic brain injury (mTBI) may impact these critical functions. In this study, seventeen patients and age-matched healthy controls (HC) performed a variant of the Stroop task and attention-demanding 4-choice response tasks (4CRT) with identical stimuli but two contexts: one required only routine responses and the other with occasional response conflicts...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29095055/diffusion-mri-findings-in-patients-with-extensive-and-minimal-post-concussion-symptoms-after-mtbi-and-healthy-controls-a-cross-sectional-study
#3
Erhard Trillingsgaard Næss-Schmidt, Jakob Udby Blicher, Anna Tietze, Charlotte Ulrikka Rask, Susanne Wulff Svendsen, Andreas Schröder, Mille Møller Thastum, Astrid Høeg Tuborgh, Oana-Veronica Frederiksen, Leif Østergaard, Simon Fristed Eskildsen, Brian Hansen, Sune Jespersen, Jørgen Feldbæk Nielsen
PRIMARY OBJECTIVES: We hypothesized that the microstructure of the corpus callosum, thalamus and hippocampus, as measured with diffusion and Mean of the Kurtosis Tensor (MKT) MRI, differs between healthy subjects and patients with extensive and minimal post-concussion symptoms (PCS) and that MKT measures correlate with PCS severity and self-reported cognitive symptoms. RESEARCH DESIGN: A cross-sectional study comparing patients with extensive PCS and patients with minimal PCS 2-5 months after mild traumatic brain injury (mTBI) with each other and with an external healthy control group...
November 2, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29084034/risk-factors-for-prolonged-symptoms-of-mild-traumatic-brain-injury-a-pediatric-sports-concussion-clinic-cohort
#4
Shayne D Fehr, Lindsay D Nelson, Kyle R Scharer, Elizabeth A Traudt, Joshua M Veenstra, Sergey S Tarima, Xue-Cheng Liu, Kevin D Walter
OBJECTIVE: To examine predictors of prolonged symptom duration from mild traumatic brain injury (mTBI) in a pediatric sports medicine specialty clinic cohort as these predictors may be distinct in this population. DESIGN: Retrospective chart review. SETTING: Outpatient specialty clinic. PATIENTS: Charts of 549 patients (age range: 10-18 years) with concussions were reviewed in an outpatient clinic that predominantly managed sports-related injuries (77...
October 26, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29069278/performance-validity-neurocognitive-disorder-and-post-concussion-symptom-reporting-in-service-members-with-a-history-of-mild-traumatic-brain-injury
#5
Sara M Lippa, Rael T Lange, Louis M French, Grant L Iverson
Objective: To examine the influence of different performance validity test (PVT) cutoffs on neuropsychological performance, post-concussion symptoms, and rates of neurocognitive disorder and postconcussional syndrome following mild traumatic brain injury (MTBI) in active duty service members. Method: Participants were 164 service members (Age: M = 28.1 years [SD = 7.3]) evaluated on average 4.1 months (SD = 5.0) following injury. Participants were divided into three mutually exclusive groups using original and alternative cutoff scores on the Test of Memory Malingering (TOMM) and the Effort Index (EI) from the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): (a) PVT-Pass, n = 85; (b) Alternative PVT-Fail, n = 53; and (c) Original PVT-Fail, n = 26...
October 21, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29060581/evidence-of-brain-functional-deficits-following-sport-related-mild-traumatic-brain-injury
#6
Tamanna Tabassum Khan Munia, Ali Haider, Reza Fazel-Rezai
Sport related mild traumatic brain injury (mTBI), generally known as a concussion, is a worldwide critical public health concern nowadays. Despite growing concern emphasized by scientific research and recent media presentation regarding mTBI and its effect in athletics life, the management, and prevention of mTBI are still not properly done. The evaluation mainly hampered due to the lack of proper knowledge, subjective nature of assessment tools including the fact that the brain functional deficits after mTBI can be mild or hidden...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28980825/does-the-fear-avoidance-model-explain-persistent-symptoms-after-traumatic-brain-injury
#7
Melloney L M Wijenberg, Sven Z Stapert, Jeanine A Verbunt, Jennie L Ponsford, Caroline M Van Heugten
BACKGROUND: A minority of patients with mild traumatic brain injury (mTBI) experience a persistent symptom complex also known as post-concussion syndrome. Explanations for this syndrome are still lacking. OBJECTIVE: To investigate if the fear avoidance model, including catastrophizing thoughts and fear avoidance behaviour, poses a possible biopsychosocial explanation for lingering symptoms and delay in recovery after traumatic brain injury (TBI) with special focus on mTBI...
October 5, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28979609/examining-microstructural-white-matter-in-active-duty-soldiers-with-a-history-of-mild-traumatic-brain-injury-and-traumatic-stress
#8
Michael N Dretsch, Rael T Lange, Jeffery S Katz, Adam Goodman, Thomas A Daniel, Gopikrishna Deshpande, Thomas S Denney, Grant L Iverson, Jennifer L Robinson
BACKGROUND: There is a high comorbidity of posttraumatic stress (PTS) and mild traumatic brain injury (mTBI), with largely overlapping symptomatology, in military service members. OBJECTIVE: To examine white matter integrity associated with PTS and mTBI as assessed using diffusion tensor imaging (DTI). METHOD: Seventy-four active-duty U.S. soldiers with PTS (n = 16) and PTS with co-morbid history of mTBI (PTS/mTBI; n = 28) were compared to a military control group (n = 30)...
2017: Open Neuroimaging Journal
https://www.readbyqxmd.com/read/28972405/staying-in-the-game-a-pilot-study-examining-the-efficacy-of-protective-headgear-in-an-animal-model-of-mild-traumatic-brain-injury-mtbi
#9
Sydney Candy, Irene Ma, Jill M McMahon, Michael Farrell, Richelle Mychasiuk
PRIMARY OBJECTIVE: Rugby is one of the few contact sports that do not mandate protective headgear, possibly because studies have shown poor efficacy for protection related to concussion pathology with existing headguards. RESEARCH DESIGN: Following innovative material technology utilization to produce headgear believed to have protective capabilities, this study examined the effects of a soft-shell headgear constructed from a novel viscoelastic material, on both behaviour and serum biomarkers after high and average impact force mild traumatic brain injuries (mTBI)...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28969486/prognostic-value-of-s-100%C3%A3-protein-for-prediction-of-post-concussion-symptoms-following-a-mild-traumatic-brain-injury-systematic-review-and-meta-analysis
#10
Eric Mercier, Pier-Alexandre Tardif, Peter Cameron, Brice Lionel Batomen Kuimi, Marcel Émond, Lynne Moore, Biswadev Mitra, Jérôme Frenette, Elaine de Guise, Marie-Christine Ouellet, Martine Bordeleau, Natalie Le Sage
This systematic review and meta-analysis aimed to determine the prognostic value of S-100β protein to identify patients with post-concussion symptoms following a mild traumatic brain injury (mTBI). A search strategy was submitted to seven databases from their inception to October 2016. Individual patient data were requested. Cohort studies evaluating the association between S-100β protein level and post-concussion symptoms assessed at least seven days after the mTBI were considered. Outcomes were dichotomised as persistent (>= 3 months) or early (>= 7 days < 3 months)...
October 2, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28967326/cerebral-blood-flow-after-mild-traumatic-brain-injury-associations-between-symptoms-and-post-injury-perfusion
#11
Jaclyn A Stephens, Peiying Liu, Hanzang Lu, Stacy J Suskauer
Arterial spin labeling (ASL) has emerged as a technique for assessing mild traumatic brain injury (mTBI), as it can non-invasively evaluate cerebrovascular physiology. To date, there is substantial variability in methodology and findings of ASL studies of mTBI. While both increased and decreased perfusion are reported after mTBI, more consistency is emerging when perfusion is examined with regard to symptomology. We evaluated 15 teenage athletes 2 and 6 weeks after sports-related concussion (SRC group) using pseudo-continuous ASL...
October 1, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28963310/characteristics-of-patients-included-and-enrolled-in-studies-on-the-prognostic-value-of-serum-biomarkers-for-prediction-of-postconcussion-symptoms-following-a-mild-traumatic-brain-injury-a-systematic-review
#12
Eric Mercier, Pier-Alexandre Tardif, Marcel Emond, Marie-Christine Ouellet, Élaine de Guise, Biswadev Mitra, Peter Cameron, Natalie Le Sage
OBJECTIVE: Mild traumatic brain injury (mTBI) has been insufficiently researched, and its definition remains elusive. Investigators are confronted by heterogeneity in patients, mechanism of injury and outcomes. Findings are thus often limited in generalisability and clinical application. Serum protein biomarkers are increasingly assessed to enhance prognostication of outcomes, but their translation into clinical practice has yet to be achieved. A systematic review was performed to describe the adult populations included and enrolled in studies that evaluated the prognostic value of protein biomarkers to predict postconcussion symptoms following an mTBI...
September 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28925734/a-pilot-treatment-study-for-mild-traumatic-brain-injury-neuroimaging-changes-detected-by-meg-after-low-intensity-pulse-based-transcranial-electrical-stimulation
#13
Ming-Xiong Huang, Ashley Robb Swan, Annemarie Angeles Quinto, Scott Matthews, Deborah L Harrington, Sharon Nichols, Barry J Bruder, Corey C Snook, Charles W Huang, Dewleen G Baker, Roland R Lee
BACKGROUND: Mild traumatic brain injury (mTBI) is a leading cause of sustained impairments in military service members, Veterans, and civilians. However, few treatments are available for mTBI, partially because the mechanism of persistent mTBI deficits is not fully understood. METHODS: We used magnetoencephalography (MEG) to investigate neuronal changes in individuals with mTBI following a passive neurofeedback-based treatment programme called IASIS. This programme involved applying low-intensity pulses using transcranial electrical stimulation (LIP-tES) with electroencephalography monitoring...
September 19, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28924170/the-tyrosine-phosphatase-ptpn13-fap-1-links-calpain-2-tbi-and-tau-tyrosine-phosphorylation
#14
Yubin Wang, Randy A Hall, Moses Lee, Andysheh Kamgar-Parsi, Xiaoning Bi, Michel Baudry
Traumatic brain injury (TBI) increases the risk of Alzheimer's disease (AD). Calpain activation and tau hyperphosphorylation have been implicated in both TBI and AD. However, the link between calpain and tau phosphorylation has not been fully identified. We recently discovered that the two major calpain isoforms in the brain, calpain-1 and calpain-2, play opposite functions in synaptic plasticity and neuronal survival/death, which may be related to their different C-terminal PDZ binding motifs. Here, we identify the tyrosine phosphatase PTPN13 as a key PDZ binding partner of calpain-2...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28916167/structural-neuroimaging-in-sport-related-concussion
#15
Erin D Bigler
Structural neuroimaging of athletes who have sustained a sports-related concussion (SRC) can be viewed as either standard clinical imaging or with advanced neuroimaging methods that quantitatively assess brain structure. Negative findings from conventional computed tomography (CT) or magnetic resonance imaging (MRI) are the norm in SRC. Nonetheless, these conventional measures remain the first line of neuroimaging of the athlete as they do detect clinically significant pathologies, when present, such as hemorrhagic abnormalities in the form of hematomas, contusions and mircobleeds along with regions of focal encephalomalacia or other signal abnormalities, with CT best capable of detecting skull fractures...
September 12, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28895491/preliminary-validation-of-the-whodas-2-0-for-mild-traumatic-brain-injury
#16
Deborah Snell, Grant L Iverson, William Panenka, Noah D Silverberg
The purpose of this study is to examine the reliability, factor structure, and validity of the World Health Organization Disability Assessment Schedule (WHODAS 2.0 12-item version) in a sample of patients who were slow to recover from a mild traumatic brain injury (MTBI). Participants were 79 adults with MTBI recruited from one of four specialty outpatient clinics in Vancouver, Canada. The WHODAS 2.0 12-item version is a disease-non-specific measure of disability representing six International Classification of Disability, Functioning, and Health activity and participation domains including cognition, mobility, self-care, interpersonal functioning, life activities, and participation...
September 12, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28894835/the-use-of-oculomotor-vestibular-and-reaction-time-tests-to-assess-mild-traumatic-brain-injury-mtbi-over-time
#17
Michael E Hoffer, Carey Balaban, Mikhaylo Szczupak, James Buskirk, Hillary Snapp, James Crawford, Sean Wise, Sara Murphy, Kathryn Marshall, Constanza Pelusso, Sean Knowles, Alex Kiderman
OBJECTIVES: The objective of this work is to examine the outcomes of a set of objective measures for evaluating individuals with minor traumatic brain injury (mTBI) over the sub-acute time period. These methods involve tests of oculomotor, vestibular, and reaction time functions. This work expands upon published work examining these test results at the time of presentation. STUDY DESIGN: This study is a prospective age- and sex-matched controlled study. MATERIALS AND METHODS: The subject group was composed of 106 individuals with mTBI and 300 age- and sex-matched controls without a history of mTBI...
August 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28889832/intra-individual-cognitive-variability-an-examination-of-anam4-tbi-mil-simple-reaction-time-data-from-service-members-with-and-without-mild-traumatic-brain-injury
#18
Wesley R Cole, Emma Gregory, Jacques P Arrieux, F Jay Haran
OBJECTIVES: The Automated Neuropsychological Assessment Metrics 4 TBI-MIL (ANAM4) is a computerized cognitive test often used in post-concussion assessments with U.S. service members (SMs). Existing evidence, however, remains mixed regarding ANAM4's ability to identify cognitive issues following mild traumatic brain injury (mTBI). Studies typically examine ANAM4 by comparing mean scores to baseline or normative scores. A more fine-grained approach involves examining inconsistency within an individual's performance...
September 11, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28882543/longitudinal-study-of-a-nogo-p3-event-related-potential-component-following-mild-traumatic-brain-injury-in-adults
#19
Gian Candrian, Andreas Müller, Patrizia Dall'Acqua, Kyveli Kompatsiari, Gian-Marco Baschera, Ladislav Mica, Hans-Peter Simmen, Richard Glaab, Javier Fandino, Markus Schwendinger, Christoph Meier, Erika Jasmin Ulbrich, Sönke Johannes
BACKGROUND: Event-related potentials have repeatedly revealed electrophysiological markers of cognitive dysfunction associated with Mild Traumatic Brain Injury (MTBI) and may represent a sensitive tool to guide cognitive rehabilitative interventions. We previously found patients with symptomatic MTBI characterized by smaller P300 (or P3) wave amplitudes in a NoGo-P3 subcomponent in the acute phase of the injury. The goal of this longitudinal study was to investigate whether this early NoGo-P3 subcomponent differs over time in symptomatic MTBI patients and healthy controls...
September 4, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28876149/acute-post-concussive-symptoms-in-young-children
#20
Coco Bernard, Audrey McKinlay, David Krieser, Renee Testa, And Jennie Ponsford
OBJECTIVES: Despite peaks of mild traumatic brain injury (mTBI) incidence in young children, few studies have examined the nature of post-concussive symptoms (PCSs) in children under the age of eight, whilst controlling for pre-injury symptoms and effects of trauma. The current study aimed to identify which PCSs differentiate children with mTBI from trauma controls early post-injury, and whether these differed among preschool and school-aged children. METHODS: The sample comprised 101 children aged 2-12 presenting to an emergency department, with concussion or other minor bodily injury (control)...
2017: Brain Injury: [BI]
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