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https://www.readbyqxmd.com/read/28726717/mini-review-of-controlled-cortical-impact-a-well-suited-device-for-concussion-research
#1
REVIEW
Nicole Osier, C Edward Dixon
Mild traumatic brain injury (mTBI) is increasingly recognized as a significant public health problem which warrants additional research. Part of the effort to understand mTBI and concussion includes modeling in animals. Controlled cortical impact (CCI) is a commonly employed and well-characterized model of experimental TBI that has been utilized for three decades. Today, several commercially available pneumatic- and electromagnetic-CCI devices exist as do a variety of standard and custom injury induction tips...
July 20, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28710227/advancing-concussion-assessment-in-pediatrics-a-cap-a-prospective-concurrent-cohort-longitudinal-study-of-mild-traumatic-brain-injury-in-children-protocol-study
#2
Keith Owen Yeates, Miriam Beauchamp, William Craig, Quynh Doan, Roger Zemek, Bruce Bjornson, Jocelyn Gravel, Angelo Mikrogianakis, Bradley Goodyear, Nishard Abdeen, Christian Beaulieu, Mathieu Dehaes, Sylvain Deschenes, Ashley Harris, Catherine Lebel, Ryan Lamont, Tyler Williamson, Karen Maria Barlow, Francois Bernier, Brian L Brooks, Carolyn Emery, Stephen B Freedman, Kristina Kowalski, Kelly Mrklas, Lianne Tomfohr-Madsen, Kathryn J Schneider
INTRODUCTION: Paediatric mild traumatic brain injury (mTBI) is a public health burden. Clinicians urgently need evidence-based guidance to manage mTBI, but gold standards for diagnosing and predicting the outcomes of mTBI are lacking. The objective of the Advancing Concussion Assessment in Pediatrics (A-CAP) study is to assess a broad pool of neurobiological and psychosocial markers to examine associations with postinjury outcomes in a large sample of children with either mTBI or orthopaedic injury (OI), with the goal of improving the diagnosis and prognostication of outcomes of paediatric mTBI...
July 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28693815/comorbid-mild-traumatic-brain-injury-increases-pain-symptoms-in-patients-suffering-from-an-isolated-limb-fracture
#3
Marianne Jodoin, Dominique M Rouleau, Nadia Gosselin, Benoit Benoit, Stéphane Leduc, Yves Laflamme, Camille Larson-Dupuis, Louis De Beaumont
OBJECTIVES: This study seeks to evaluate the effects of a mild traumatic brain injury (mTBI) on pain in patients with an isolated limb fracture (ILF) when compared to a matched cohort group with no mTBI (control group). PATIENTS AND METHODS: All subjects included in this observational study suffered from an ILF. Groups were matched according to the type of injury, sex, age, and time since the accident. Main outcome measurements were: Standardized semi-structured interviews at follow-up of a Level I Trauma Center, and a questionnaire on fracture-related pain symptoms...
July 1, 2017: Injury
https://www.readbyqxmd.com/read/28685977/the-post-therapeutic-effect-of-rapamycin-in-mild-traumatic-brain-injured-rats-ensuing-in-the-upregulation-of-autophagy-and-mitophagy
#4
Changxing Wang, Zhiying Hu, Yang Zou, Mingjun Xiang, Yuting Jiang, Benson O A Botchway, Xue Huo, Xiaoxue Du, Marong Fang
Mild traumatic brain injury (mTBI), common in juveniles, has been reported to be caused by sports-related concussion. Many young children may suffer from post-concussion syndrome. mTBI, in early stages of life, could play a part in neuron apoptosis and degeneration, cognitive and motor coordination impairment, as well as dementia. Our study was aimed at further investigating the post therapeutic efficacy of rapamycin in the recuperation of mTBI whiles at the same time investigating the metamorphosis in both autophagy and mitophagy in mTBI...
July 7, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28676987/white-matter-abnormalities-in-mild-traumatic-brain-injury-with-and-without-post-traumatic-stress-disorder-a-subject-specific-diffusion-tensor-imaging-study
#5
Christian Lepage, Amicie de Pierrefeu, Inga K Koerte, Michael J Coleman, Ofer Pasternak, Gerald Grant, Christine E Marx, Rajendra A Morey, Laura A Flashman, Mark S George, Thomas W McAllister, Norberto Andaluz, Lori Shutter, Raul Coimbra, Ross D Zafonte, Murray B Stein, Martha E Shenton, Sylvain Bouix
Mild traumatic brain injuries (mTBIs) are often associated with posttraumatic stress disorder (PTSD). In cases of chronic mTBI, accurate diagnosis can be challenging due to the overlapping symptoms this condition shares with PTSD. Furthermore, mTBIs are heterogeneous and not easily observed using conventional neuroimaging tools, despite the fact that diffuse axonal injuries are the most common injury. Diffusion tensor imaging (DTI) is sensitive to diffuse axonal injuries and is thus more likely to detect mTBIs, especially when analyses account for the inter-individual variability of these injuries...
July 5, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28664033/decreased-susceptibility-of-major-veins-in-mild-traumatic-brain-injury-is-correlated-with-post-concussive-symptoms-a-quantitative-susceptibility-mapping-study
#6
Chao Chai, Rui Guo, Chao Zuo, Linlin Fan, Saifeng Liu, Tianyi Qian, E Mark Haacke, Shuang Xia, Wen Shen
Cerebral venous oxygen saturation (SvO2) is an important biomarker of brain function. In this study, we aimed to explore the relative changes of regional cerebral SvO2 among axonal injury (AI) patients, non-AI patients and healthy controls (HCs) using quantitative susceptibility mapping (QSM). 48 patients and 32 HCs were enrolled. The patients were divided into two groups depending on the imaging based evidence of AI. QSM was used to measure the susceptibility of major cerebral veins. Nonparametric testing was performed for susceptibility differences among the non-AI patient group, AI patient group and healthy control group...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28655191/iatrogenic-effect-cautions-when-utilizing-an-early-health-education-for-post-concussion-symptoms
#7
Chi-Cheng Yang, Hsiao-Chun Chiu, Sheng-Huang Xiao, Yi-Hsin Tsai, Yi-Chien Lee, Yi-Ting Ku, Rong-Syuan Lin, Wei-Chi Lin, Sheng-Jean Huang
Objective: Patients with mild traumatic brain injury (MTBI) usually suffer from the post-concussion symptoms (PCS). PCS could recover by 3 months post-injury, but some patients still persistently complain of those symptoms for years. Accordingly, the Chang-Gung University Brief Intervention for Post-Concussion Symptoms (CGU-BIPCS) was developed to intervene PCS based on the established advantages of health education. This prospective study thus aims to evaluate the effectiveness of CGU-BIPCS for patients with MTBI...
June 26, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28654066/a-mouse-model-of-single-and-repetitive-mild-traumatic-brain-injury
#8
Bevan S Main, Stephanie S Sloley, Sonia Villapol, David N Zapple, Mark P Burns
Mild Traumatic Brain Injury (mTBI) can result in the acute loss of brain function, including a period of confusion, a loss of consciousness (LOC), focal neurological deficits and even amnesia. Athletes participating in contact sports are at high risk of exposure to large number of mTBIs. In terms of the level of injury in a sporting athlete, a mTBI is defined as a mild injury that does not cause gross pathological changes, but does cause short-term neurological deficits that are spontaneously resolved. Despite previous attempts to model mTBI in mice and rats, many have reported gross adverse effects including skull fractures, intracerebral bleeding, axonal injury and neuronal cell death...
June 20, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28650685/colored-glasses-to-mitigate-photophobia-symptoms-posttraumatic-brain-injury
#9
Joseph Clark, Kim Hasselfeld, Katy Bigsby, Jon Divine
CONTEXT:   After a concussion or mild traumatic brain injury (mTBI), patients often suffer from light sensitivity, or photophobia, which contributes to decreased quality of life post-mTBI. Whereas sunglasses may provide some relief from photophobia, they are not practical indoors or in low light. A light-mitigation strategy that can be easily used indoors as needed to optimize the relief. We have found that many photophobic patients experience relief using colored sunglasses. OBJECTIVE:   To provide the athletic trainer with a means and method to assess whether an athlete is suffering from photophobia after concussion and to determine if colored glasses provide relief...
June 26, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28630809/technical-report-of-the-use-of-a-novel-eye-tracking-system-to-measure-impairment-associated-with-mild-traumatic-brain-injury
#10
Michael Kelly
This technical report details the results of an uncontrolled study of EyeGuide Focus, a 10-second concussion management tool which relies on eye tracking to determine the potential impairment of visual attention, an indicator often of mild traumatic brain injury (mTBI). Essentially, people who can visually keep steady and accurate attention on a moving object in their environment likely suffer from no impairment. However, if after a potential mTBI event, subjects cannot keep attention on a moving object in a normal way as demonstrated on their previous healthy baseline tests...
May 15, 2017: Curēus
https://www.readbyqxmd.com/read/28604837/dynamic-changes-in-diffusion-measures-improve-sensitivity-in-identifying-patients-with-mild-traumatic-brain-injury
#11
Alexander W Thomas, Richard Watts, Christopher G Filippi, Joshua P Nickerson, Trevor Andrews, Gregory Lieberman, Magdalena R Naylor, Margaret J Eppstein, Kalev Freeman
The goal of this study was to investigate patterns of axonal injury in the first week after mild traumatic brain injury (mTBI). We performed a prospective cohort study of 20 patients presenting to the emergency department with mTBI, using 3.0T diffusion tensor MRI immediately after injury and again at 1 week post-injury. Corresponding data were acquired from 16 controls over a similar time interval. Fractional anisotropy (FA) and other diffusion measures were calculated from 11 a priori selected axon tracts at each time-point, and the change across time in each region was quantified for each subject...
2017: PloS One
https://www.readbyqxmd.com/read/28602630/correlation-between-standardized-assessment-of-concussion-scores-and-small-world-brain-network-in-mild-traumatic-brain-injury
#12
Yan Yan, Jian Song, Guozheng Xu, Shun Yao, Chenglong Cao, Chang Li, Guibao Peng, Hao Du
This study investigated the characteristics of the small-world brain network architecture of patients with mild traumatic brain injury (MTBI), and a correlation between brain functional connectivity network properties in the resting-state fMRI and Standardized Assessment of Concussion (SAC) parameters. The neurological conditions of 22 MTBI patients and 17 normal control individuals were evaluated according to the SAC. Resting-state fMRI was performed in all subjects 3 and 7days after injury respectively. After preprocessing the fMRI data, cortex functional regions were marked using AAL90 and Dosenbach160 templates...
June 8, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28599608/a-brain-electrical-activity-eeg-based-biomarker-of-functional-impairment-in-traumatic-head-injury-a-multisite-validation-trial
#13
Daniel Hanley, Leslie S Prichep, Neeraj Badjatia, Jeff Bazarian, RIchard P Chiacchierini, Kenneth C Curley, John S Garrett, Elizabeth B Jones, Rosanne Naunheim, Brian J O'Neil, John O'Neill, Wright David, J Stephen Huff
The potential clinical utility of a novel quantitative EEG-based Brain Function Index (BFI) as a measure of the presence and severity of functional brain injury was studied as part of an independent prospective validation trial. The BFI was derived using EEG features associated with functional brain impairment reflecting current consensus on the physiology of concussive injury. 720 adult patients (18-85 years) evaluated within 72 hours of sustaining a closed head injury were enrolled at 11 US Emergency Departments...
June 9, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28593091/a-comprehensive-instrument-for-evaluating-mild-traumatic-brain-injury-mtbi-concussion-in-independent-adults-a-pilot-study
#14
Amanda Borges, Scot Raab, Monica Lininger
BACKGROUND: One common component of concussion rehabilitation is a computerized cognitive test free of concomitant physical demands. Healthcare professionals may be able to provide more patient-centered care after a diagnosed concussion if specific areas of impairment are identified and treated, such as the physical aspect of neurocognitive function. Hypothesis/Purpose: To evaluate the test-retest reliability of a unique combination of neurocognitive assessment tools currently utilized in concussion assessments into one single, inclusive instrument that measures both neurocognitive function and physical capability...
June 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28579327/manipulating-cognitive-reserve-pre-injury-environmental-conditions-influence-the-severity-of-concussion-symptomology-gene-expression-and-response-to-melatonin-treatment-in-rats
#15
Glenn R Yamakawa, Sabrina Salberg, Karen M Barlow, Brian L Brooks, Michael J Esser, Keith Owen Yeates, Richelle Mychasiuk
In an effort to understand the factors that contribute to heterogeneity in outcomes often associated with mTBI in youth, this study examined the role of premorbid differences in cognitive reserve on post-concussive symptoms (PCS), molecular markers, and treatment response. Male and female rats matured in one of three environmental conditions (Stress, Enrichment, Control), received a mTBI in adolescence, and were randomized to melatonin or placebo treatment. All animals underwent a behavioural test battery designed to examine PCS...
June 1, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28527643/parental-knowledge-and-recall-of-concussion-discharge-instructions
#16
Danny George Thomas, Lia Bradley, Ashley Servi, Suzanne Reilly, Jennifer Niskala Apps, Michael McCrea, Thomas Hammeke
INTRODUCTION: Children increasingly are being seen in the emergency department for a concussion, or mild traumatic brain injury (mTBI). A key aim of the ED visit is to provide discharge advice that can help parents to identify an evolving neurosurgical crisis, facilitate recovery, and prevent reinjury. The present study examined parents' knowledge of symptoms and recall of discharge instructions after their adolescent's mTBI and the effect of supplementing written discharge instructions with verbal instruction and reinforcement...
May 17, 2017: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
https://www.readbyqxmd.com/read/28520668/structural-connectivity-related-to-persistent-symptoms-after-mild-tbi-in-adolescents-and-response-to-aerobic-training-preliminary-investigation
#17
Weihong Yuan, Shari L Wade, Catherine Quatman-Yates, Jason A Hugentobler, Paul J Gubanich, Brad G Kurowski
OBJECTIVE: To quantify structural connectivity abnormalities in adolescents with mild traumatic brain injury (mTBI) and to investigate connectivity changes following aerobic training using graph theory and diffusion tensor imaging tractography. SETTING: Outpatient research setting. PARTICIPANTS: Twenty-two children (age: 15.83 ± 1.77 years, 10 females) with 4 to 16 weeks of persistent symptoms after mTBI and a matched healthy comparison group...
May 17, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28512443/transcranial-direct-current-stimulation-for-post-concussion-syndrome-study-protocol-for-a-randomized-crossover-trial
#18
Robson Luis Oliveira de Amorim, André Russowsky Brunoni, Mirian Akiko Furutani de Oliveira, Ana Luiza Costa Zaninotto, Marcia Mitie Nagumo, Vinícius Monteiro de Paula Guirado, Iuri Santana Neville, Gláucia Rosana Guerra Benute, Mara Cristina Souza de Lucia, Wellingson Silva Paiva, Almir Ferreira de Andrade, Manoel Jacobsen Teixeira
BACKGROUND: Mild traumatic brain injury (MTBI) represents 70-80% of all treated brain injuries. A considerable proportion of MTBI patients experience post-concussion symptoms for a prolonged period after MTBI, and these symptoms are diagnosed as persistent post-concussion syndrome (PPCS). PPCS is defined as a range of physical, cognitive, and emotional symptoms. However, memory and executive dysfunction seems to be one of the most debilitating symptoms. Recently, non-invasive brain stimulation has been studied as a potential treatment method for traumatic brain injury (TBI) patients...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28499856/measuring-soldier-performance-during-the-patrol-exertion-multitask-preliminary-validation-of-a-post-concussive-functional-return-to-duty-metric
#19
Matthew Scherer, Margaret M Weightman, Mary Vining Radomski, Laurel Smith, Marsha Finkelstein, Amy Cecchini, Kristin Jensen Heaton, Karen McCulloch
OBJECTIVE: To assess the discriminant validity of the Patrol-Exertion Multitask (PEMT), a novel, multi-domain, functional return-to-duty clinical assessment for Active Duty military personnel. DESIGN: Measurement development study SETTING: Non-clinical indoor testing facility, Fort Bragg NC PARTICIPANTS: 51 healthy control (HC) Service Members and 33 military personnel with persistent post-concussive symptoms receiving rehabilitation (mTBI) INTERVENTION: Not applicable MAIN OUTCOME MEASURES: Known-groups discriminant validity was evaluated by comparing performance on the PEMT in two groups of Active Duty SM, HC and personnel with mTBI residual symptoms...
May 9, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28434160/repeated-mild-traumatic-brain-injuries-is-not-associated-with-volumetric-differences-in-former-high-school-football-players
#20
Douglas P Terry, L Stephen Miller
We investigated potential brain volumetric differences in a sample of former high school football players many years after these injuries. Forty community-dwelling males ages 40-65 who played high school football, but not college or professional sports, were recruited. The experimental group (n = 20) endorsed experiencing two or more mTBIs on an empirically validated mTBI assessment tool (median = 3, range = 2-15). The control group (n = 20) denied ever experiencing an mTBI. Participants completed a self-report index of current mTBI symptomatology and underwent high-resolution T1-weighted MRI scanning, which were analyzed using the Freesurfer software package...
April 22, 2017: Brain Imaging and Behavior
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