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https://www.readbyqxmd.com/read/27919376/usability-evaluation-of-the-smart-application-for-youth-with-mtbi
#1
Judith W Dexheimer, Brad G Kurowski, Shilo H Anders, Nicole McClanahan, Shari L Wade, Lynn Babcock
OBJECTIVE: There is a dearth of evidence-based treatments available to address the significant morbidity associated with mild traumatic brain injury (mTBI). To address this gap, we designed a novel user-friendly, web-based application. We describe the preliminary evaluation of feasibility and usability of the application to promote recovery following mTBI in youth, the Self-Monitoring Activity-Restriction and Relaxation Treatment (SMART). SMART incorporates real-time recommendations for individualized symptom management and activity restriction along with training in cognitive-behavioral coping strategies...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27916406/cortical-excitability-after-pediatric-mild-traumatic-brain-injury
#2
Trevor A Seeger, Adam Kirton, Michael J Esser, Clare Gallagher, Jeff Dunn, Ephrem Zewdie, Omar Damji, Patrick Ciechanski, Karen M Barlow
INTRODUCTION: Mild traumatic brain injury (mTBI) outcomes are variable, and 10-15% may suffer from prolonged symptoms beyond 3 months that impair the child's return to normal activities. Neurophysiological mechanisms of mTBI are incompletely understood, particularly in children, but alterations in cortical excitability have been proposed to underlie post-concussion syndrome. Improved understanding is required to advance interventions and improve outcomes. OBJECTIVE/HYPOTHESIS: To determine if cortical excitability is altered in children with mTBI, and its association with clinical symptoms...
November 19, 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27913365/portable-mtbi-assessment-using-temporal-and-frequency-analysis-of-speech
#3
Louis Daudet, Nikhil Yadav, Matthew Perez, Christian Poellabauer, Sandra Schneider, Alan Huebner
This paper shows that extraction and analysis of various acoustic features from speech using mobile devices can allow the detection of patterns that could be indicative of neurological trauma. This may pave the way for new types of biomarkers and diagnostic tools. Toward this end, we created a mobile application designed to diagnose mild traumatic brain injuries (mTBI) such as concussions. Using this application, data was collected from youth athletes from 47 high schools and colleges in the the Midwestern United States...
December 1, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/27906973/detecting-mild-traumatic-brain-injury-using-resting-state-magnetoencephalographic-connectivity
#4
Vasily A Vakorin, Sam M Doesburg, Leodante da Costa, Rakesh Jetly, Elizabeth W Pang, Margot J Taylor
Accurate means to detect mild traumatic brain injury (mTBI) using objective and quantitative measures remain elusive. Conventional imaging typically detects no abnormalities despite post-concussive symptoms. In the present study, we recorded resting state magnetoencephalograms (MEG) from adults with mTBI and controls. Atlas-guided reconstruction of resting state activity was performed for 90 cortical and subcortical regions, and calculation of inter-regional oscillatory phase synchrony at various frequencies was performed...
December 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27902865/small-world-properties-changes-in-mild-traumatic-brain-injury
#5
Yongxia Zhou
PURPOSE: To investigate local and global efficiency changes characterized by small-world properties based on resting-state functional MRI, such as centrality and clustering coefficient, in mild traumatic brain injury (MTBI) patients; and to associate these findings with axonal injury as measured by diffusion tensor imaging (DTI) as well as with post-concussive symptom (PCS). MATERIALS AND METHODS: Thirty patients (mean age 35 ± 13 years) with clinically defined MTBI and 45 age-matched healthy controls (mean age 37 ± 10 years) participated in the experiments...
November 30, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27886529/autobiographical-and-episodic-memory-deficits-in-mild-traumatic-brain-injury
#6
Jeffrey D Wammes, Tyler J Good, Myra A Fernandes
Those who have suffered a concussion, otherwise known as a mild traumatic brain injury (mTBI), often complain of lingering memory problems. However, there is little evidence in the behavioral literature reliably demonstrating memory deficits. Thus, in the present study, cognitive profiles including measures of general executive functioning and processing speed, as well as episodic and semantic memory were collected in younger and older adult participants with or without a remote (>1year prior to testing) mTBI...
November 22, 2016: Brain and Cognition
https://www.readbyqxmd.com/read/27858189/ambulatory-or-inpatient-management-of-mild-tbi-in-children-a-post-concussion-analysis
#7
Danielle S Wendling-Keim, Adriana König, Hans-Georg Dietz, Markus Lehner
BACKGROUND: Diagnosis and treatment of children with mild traumatic brain injury (mTBI) remain a challenge since initial signs and symptoms do not always indicate the severity of the trauma. Therefore, guidelines regarding the decision upon imaging methods and ambulatory or hospitalized treatment are needed. The goal of our study was to investigate if the standard that was allied from the PECARN rules and is applied in this study can ensure that patients with clinically important brain injury are recognized and leads to outcomes with a low complication rate, a high patient satisfaction and minimal post-concussion syndrome incidence...
November 17, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27843436/lifetime-multiple-mild-traumatic-brain-injuries-are-associated-with-cognitive-and-mood-symptoms-in-young-healthy-college-students
#8
Kyle C Vynorius, Alyssa M Paquin, Daniel R Seichepine
BACKGROUND/OBJECTIVES: Repetitive mild traumatic brain injury (mTBI, also known as concussion) has been associated with a range of long-term mood and cognitive deficits, including executive dysfunction. Previous research in athletes suggests that cognitive and mood problems are associated with a history of repetitive mTBI. However, to date, no studies have examined the impact of a lifetime accumulation of repetitive mTBIs on cognition, particularly executive functioning, and mood in a sample of young adults who were not athletes...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27792852/cognitive-rest-and-graduated-return-to-usual-activities-versus-usual-care-for-mild-traumatic-brain-injury-a-randomized-controlled-trial-of-emergency-department-discharge-instructions
#9
Catherine E Varner, Shelley McLeod, Negine Nahiddi, Rosamond E Lougheed, Taylor E Dear, Bjug Borgundvaag
INTRODUCTION: It is estimated 15-25% of patients with a mild traumatic brain injury (MTBI) diagnosed in the emergency department (ED) will develop post-concussive syndrome (PCS). The objective of this study was to determine if patients randomized to graduated return to usual activity discharge instructions had a decrease in their Post-Concussion Symptom Score (PCSS) 2 weeks after MTBI compared to patients who received usual care MTBI discharge instructions. METHODS: This was a pragmatic, randomized trial of adult (18-64 years) patients of an academic ED (annual census 60,000) diagnosed with MTBI occurring within 24 hours of ED visit...
October 28, 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/27784200/prevalence-of-incomplete-functional-and-symptomatic-recovery-among-patients-with-head-injury-but-brain-injury-debatable-hibrid-running-title-outcomes-in-patients-with-head-injury-but-brain-injury-debatable
#10
Frederick Kofi Korley, Ramon Diaz-Arrastia, Hayley J Falk, Matthew E Peters, Jeannie-Marie S Leoutsakos, Durga Roy, Vani Rao, Haris I Sair, Uju Ofoche, Anna J Hall, Freshta Akbari, Timothy E Van Meter, Allen D Everett, Jennifer Van Eyk, Kathleen T Bechtold
Head injury patients not meeting the American Congress of Rehabilitation Medicine (ACRM)'s criteria for mild traumatic brain injury (mTBI), referred to hereafter as HIBRID (Head Injury BRain Injury Debatable) are often excluded from studies. The prognostic importance of HIBRID is unclear. We investigated the differences in functional and symptomatic recovery at one month after injury among TBI patients classified as: HIBRID, ACRM+ cranial CT-, and cranial CT+; and trauma and healthy controls. Subjects were enrolled in an ongoing prospective cohort (Head Injury Serum Markers for Assessing Response to Trauma, HeadSMART)...
October 26, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27779341/study-of-neurometabolic-and-behavioral-alterations-in-rodent-model-of-mild-traumatic-brain-injury-a-pilot-study
#11
Kavita Singh, Richa Trivedi, Seenu Haridas, Kailash Manda, Subash Khushu
Mild traumatic brain injury (mTBI) is the most common form of TBI (70-90%) with consequences of anxiety-like behavioral alterations in approximately 23% of mTBI cases. This study aimed to assess whether mTBI-induced anxiety-like behavior is a consequence of neurometabolic alterations. mTBI was induced using a weight drop model to simulate mild human brain injury in rodents. Based on injury induction and dosage of anesthesia, four animal groups were included in this study: (i) injury with anesthesia (IA); (ii) sham1 (injury only, IO); (iii) sham2 (only anesthesia, OA); and (iv) control rats...
October 25, 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27768069/a-repetitive-concussive-head-injury-model-in-mice
#12
Zhihui Yang, Fan Lin, Amanda S Weissman, Emily Jaalouk, Qing-Shan Xue, Kevin K W Wang
Despite the concussion/ mild traumatic brain injury (mTBI) being the most frequent occurrence of traumatic brain injury, there is still a lack of knowledge on the injury and its effects. To develop a better understanding of concussions, animals are often used because they provide a controlled, rigorous, and efficient model. Studies have adapted traditional animal models to perform mTBI to stimulate mild injury severity by changing the injury parameters. These models have been used because they can produce morphologically similar brain injuries to the clinical condition and provide a spectrum of injury severities...
October 12, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27762653/resting-state-magnetoencephalography-reveals-different-patterns-of-aberrant-functional-connectivity-in-combat-related-mild-traumatic-brain-injury
#13
Ming-Xiong Huang, Deborah L Harrington, Ashley Robb Swan, Annemarie Angeles Quinto, Sharon Nichols, Angela Drake, Tao Song, Mithun Diwakar, Charles W Huang, Victoria B Risbrough, Anders Dale, Hauke Bartsch, Scott Matthews, Jeffrey W Huang, Roland R Lee, Dewleen G Baker
Blast mild traumatic brain injury (mTBI) is a leading cause of sustained impairment in military service members and veterans. However, the mechanism of persistent disability is not fully understood. The present study investigated disturbances in brain functioning in mTBI participants using a source-imaging-based approach to analyze functional connectivity (FC) from resting-state magnetoencephalography (rs-MEG). Study participants included 26 active-duty service members or veterans who had blast mTBI with persistent post-concussive symptoms, and 22 healthy control active-duty service members or veterans...
December 2, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27740864/impact-of-pre-injury-family-functioning-and-resources-on-self-reported-post-concussive-symptoms-and-functional-outcomes-in-persons-with-mild-tbi
#14
Jessica Lynn Temple, Margaret A Struchen, Monique R Pappadis
OBJECTIVE: This study investigates the contribution of pre-injury family functioning and resources on self-reported post-concussive symptoms and functional outcomes in persons with mild TBI (mTBI). DESIGN: Participants with uncomplicated or complicated mTBIs were recruited from consecutive admissions to the emergency department of a level 1 trauma centre. Patients completed baseline assessments within 2 weeks of injury and an outcomes assessment at 3 months post-injury...
October 14, 2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27708611/a-history-of-mild-traumatic-brain-injury-affects-peripheral-pulse-oximetry-during-normobaric-hypoxia
#15
Leonard A Temme, Paul St Onge, Joseph Bleiberg
INTRODUCTION: Physiological and emotional stressors increase symptoms of concussion in recently injured individuals and both forms of stress-induced symptoms in people recovering from mild traumatic brain injury (mTBI), but who are asymptomatic when not stressed or are at rest. METHODS: Healthy asymptomatic adults (25.0 ± 5.1 years) with a history of mTBI (n = 36) and matched healthy controls (HC) (n = 36) with no mTBI history were exposed to three levels of normobaric hypoxic stress generated with the Reduced Oxygen Breathing Device (ROBD) (Environics, Inc...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27698651/diffusion-tensor-imaging-findings-in-post-concussion-syndrome-patients-after-mild-traumatic-brain-injury-a-systematic-review
#16
Edrea Khong, Nicole Odenwald, Eyesha Hashim, Michael D Cusimano
OBJECTIVES: To review the evidence for the use of diffusion tensor imaging (DTI) parameters in the human brain as a diagnostic tool for and predictor of post-concussion syndrome (PCS) after a mild traumatic brain injury (mTBI). DESIGN: Systematic review. DATA SOURCES: All relevant studies in AMED, Embase, MEDLINE, Ovid, PubMed, Scopus, and Web of Science through 20 May, 2016. STUDY SELECTION: Studies that analyze traditional DTI measures [fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD)] and the severity of PCS symptoms or the development of PCS in humans after an mTBI...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27646958/assessment-of-the-king-devick%C3%A2-kd-test-for-screening-acute-mtbi-concussion-in-warfighters
#17
David V Walsh, José E Capó-Aponte, Thomas Beltran, Wesley R Cole, Ashley Ballard, Joseph Y Dumayas
OBJECTIVES: The Department of Defense reported that 344,030 cases of traumatic brain injury (TBI) were clinically confirmed from 2000 to 2015, with mild TBI (mTBI) accounting for 82.3% of all cases. Unfortunately, warfighters with TBI are often identified only when moderate or severe head injuries have occurred, leaving more subtle mTBI cases undiagnosed. This study aims to identify and validate an eye-movement visual test for screening acute mTBI. METHODS: Two-hundred active duty military personnel were recruited to perform the King-Devick® (KD) test...
September 11, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27636403/game-specific-characteristics-of-sport-related-concussions
#18
Ingo Helmich
BACKGROUND: Concussions are common incidences in sports. However, game-specific characteristics such as tactics, field positions, etc. might positively/negatively contribute to the occurrence of mild traumatic brain injuries (mTBI) in various sports such as soccer, volleyball, handball, or basketball. Thus, the intention of this study was to analyze game- specific characteristics of concussive incidents in active players from the perspective of different sportive disciplines. METHODS: Four sport-specific questionnaires for soccer, handball, volleyball and basketball were established using an online survey tool...
September 14, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27619107/predictors-of-post-concussive-symptoms-in-young-children-injury-versus-non-injury-related-factors
#19
Coco O Bernard, Jennie A Ponsford, Audrey McKinlay, Dean McKenzie, David Krieser
OBJECTIVES: A notable minority of children will experience persistent post-concussive symptoms (PCS) following mild traumatic brain injury (mTBI), likely maintained by a combination of injury and non-injury related factors. Adopting a prospective longitudinal design, this study aimed to investigate the relative influence of child, family, and injury factors on both acute and persistent PCS in young children. METHODS: Participants were 101 children aged 2-12 who presented to an Emergency Department, with either mTBI or minor bodily trauma (control)...
September 2016: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/27618518/abnormalities-in-functional-connectivity-in-collegiate-football-athletes-with-and-without-a-concussion-history-implications-and-role-of-neuroactive-kynurenine-pathway-metabolites
#20
Timothy B Meier, Melissa A Lancaster, Andrew R Mayer, T Kent Teague, Jonathan Savitz
There is a great need to identify potential long-term consequences of contact sport exposure and to identify molecular pathways that may be associated with these changes. We tested the hypothesis that football players with (Ath-mTBI) (n = 25) and without a concussion history (Ath) (n = 24) have altered resting state functional connectivity in regions with previously documented structural changes relative to healthy controls without football or concussion history (HC) (n = 27). As a secondary aim, we tested the hypothesis that group differences in functional connectivity are moderated by the relative ratio of neuroprotective to neurotoxic metabolites of the kynurenine pathway...
October 13, 2016: Journal of Neurotrauma
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