keyword
MENU ▼
Read by QxMD icon Read
search

Prebiotic

keyword
https://www.readbyqxmd.com/read/28640999/common-and-potentially-prebiotic-origin-for-precursors-of-nucleotide-synthesis-and-activation
#1
Albert C Fahrenbach, Constantin Giurgiu, Chun Pong Tam, Li Li, Yayoi Hongo, Masashi Aono, Jack W Szostak
We have recently shown that 2-aminoimidazole is a superior nucleotide activating group for nonenzymatic RNA copying. Here we describe a prebiotic synthesis of 2-aminoimidazole that shares a common mechanistic pathway with that of 2-aminooxazole, a previously described key intermediate in prebiotic nucleotide synthesis. In the presence of glycolaldehyde, cyanamide, phosphate and ammonium ion, both 2-aminoimidazole and 2-aminooxazole are produced, with higher concentrations of ammonium ion and acidic pH favoring the former...
June 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28636003/in-vitro-modulation-of-gut-microbiota-by-whey-protein-to-preserve-intestinal-health
#2
T Sánchez-Moya, R López-Nicolás, D Planes, C A González-Bermúdez, G Ros-Berruezo, C Frontela-Saseta
The effect of several types of whey milk - cow, sheep, goat and a mixture of them (60 : 20 : 20, respectively) - was assessed in the human gut microbiota. The prebiotic potential of these substrates was evaluated through in vitro gastrointestinal digestion following faecal batch culture fermentations (mimicking colonic fermentation) for 48 hours, using faeces from normal-weight (NW) and obese (OB) donors. Throughout the fermentation process, pH, gas production, short chain and branched fatty acids (SCFA-BCFA) were measured, as well as the changes of microbiota using qPCR...
June 21, 2017: Food & Function
https://www.readbyqxmd.com/read/28634691/modulation-of-rotavirus-severe-gastroenteritis-by-the-combination-of-probiotics-and-prebiotics
#3
REVIEW
Guadalupe Gonzalez-Ochoa, Lilian K Flores-Mendoza, Ramona Icedo-Garcia, Ricardo Gomez-Flores, Patricia Tamez-Guerra
Annual mortality rates due to infectious diarrhea are about 2.2 million; children are the most vulnerable age group to severe gastroenteritis, representing group A rotaviruses as the main cause of disease. One of the main factors of rotavirus pathogenesis is the NSP4 protein, which has been characterized as a viral toxin involved in triggering several cellular responses leading to diarrhea. Furthermore, the rotavirus protein NSP1 has been associated with interferon production inhibition by inducing the degradation of interferon regulatory factors IRF3, IRF5, and IRF7...
June 20, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28632732/fructo-oligosaccharides-and-intestinal-barrier-function-in-a-methionine-choline-deficient-mouse-model-of-nonalcoholic-steatohepatitis
#4
Kotaro Matsumoto, Mayuko Ichimura, Koichi Tsuneyama, Yuki Moritoki, Hiromichi Tsunashima, Katsuhisa Omagari, Masumi Hara, Ichiro Yasuda, Hiroshi Miyakawa, Kentaro Kikuchi
Impairments in intestinal barrier function, epithelial mucins, and tight junction proteins have been reported to be associated with nonalcoholic steatohepatitis. Prebiotic fructo-oligosaccharides restore balance in the gastrointestinal microbiome. This study was conducted to determine the effects of dietary fructo-oligosaccharides on intestinal barrier function and steatohepatitis in methionine-choline-deficient mice. Three groups of 12-week-old male C57BL/6J mice were studied for 3 weeks; specifically, mice were fed a methionine-choline-deficient diet, a methionine-choline-deficient diet plus 5% fructo-oligosaccharides in water, or a normal control diet...
2017: PloS One
https://www.readbyqxmd.com/read/28631091/the-role-of-microbiota-and-probiotics-and-prebiotics-in-skin-health
#5
Mia Maguire, Greg Maguire
During the past decade, scientists have made great strides in understanding the microbiome's role in human health. Today, the microbiome has become key in scientific research, therapeutic development, medical treatment, and as a news feature in the media. Most studies have focused on the microbiome of our gut, but recently researchers have turned their attention to other microbiomes, including that of the skin. These studies of gut and skin microbiomes are yielding very informative results, new treatment strategies, and the development of new prebiotic and probiotic products for the treatment of many skin conditions...
June 19, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28614379/microbiome-restoration-diet-improves-digestion-cognition-and-physical-and-emotional-wellbeing
#6
Kate Lawrence, Jeannette Hyde
Manipulating gut bacteria in the microbiome, through the use of probiotics and prebiotics, has been found to have an influence on both physical and emotional wellbeing. This study uses a dietary manipulation 'The Gut Makeover' designed to elicit positive changes to the gut bacteria within the microbiome. 21 healthy participants undertook 'The Gut Makeover' for a four week period. Weight and various aspects of health were assessed pre and post intervention using the Functional Medicine Medical Symptoms Questionnaire (MSQ)...
2017: PloS One
https://www.readbyqxmd.com/read/28614348/organic-compounds-in-fluid-inclusions-of-archean-quartz-analogues-of-prebiotic-chemistry-on-early-earth
#7
Ulrich Schreiber, Christian Mayer, Oliver J Schmitz, Pia Rosendahl, Amela Bronja, Markus Greule, Frank Keppler, Ines Mulder, Tobias Sattler, Heinz F Schöler
The origin of life is still an unsolved mystery in science. Hypothetically, prebiotic chemistry and the formation of protocells may have evolved in the hydrothermal environment of tectonic fault zones in the upper continental crust, an environment where sensitive molecules are protected against degradation induced e.g. by UV radiation. The composition of fluid inclusions in minerals such as quartz crystals which have grown in this environment during the Archean period might provide important information about the first organic molecules formed by hydrothermal synthesis...
2017: PloS One
https://www.readbyqxmd.com/read/28611480/expert-consensus-document-the-international-scientific-association-for-probiotics-and-prebiotics-isapp-consensus-statement-on-the-definition-and-scope-of-prebiotics
#8
REVIEW
Glenn R Gibson, Robert Hutkins, Mary Ellen Sanders, Susan L Prescott, Raylene A Reimer, Seppo J Salminen, Karen Scott, Catherine Stanton, Kelly S Swanson, Patrice D Cani, Kristin Verbeke, Gregor Reid
In December 2016, a panel of experts in microbiology, nutrition and clinical research was convened by the International Scientific Association for Probiotics and Prebiotics to review the definition and scope of prebiotics. Consistent with the original embodiment of prebiotics, but aware of the latest scientific and clinical developments, the panel updated the definition of a prebiotic: a substrate that is selectively utilized by host microorganisms conferring a health benefit. This definition expands the concept of prebiotics to possibly include non-carbohydrate substances, applications to body sites other than the gastrointestinal tract, and diverse categories other than food...
June 14, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28608320/chronic-treatment-with-prebiotics-probiotics-and-synbiotics-attenuated-cardiac-dysfunction-by-improving-cardiac-mitochondrial-dysfunction-in-male-obese-insulin-resistant-rats
#9
Wannipa Tunapong, Nattayaporn Apaijai, Sakawdaurn Yasom, Pongpan Tanajak, Keerati Wanchai, Titikorn Chunchai, Sasiwan Kerdphoo, Sathima Eaimworawuthikul, Parameth Thiennimitr, Anchalee Pongchaidecha, Anusorn Lungkaphin, Wasana Pratchayasakul, Siriporn C Chattipakorn, Nipon Chattipakorn
PURPOSE: In metabolic syndrome, the composition of gut microbiota has been disrupted, and is associated with left ventricular (LV) dysfunction. Several types of prebiotics, probiotics, and synbiotics have been shown to exert cardioprotection by restoring gut microbiota from dysbiosis and reducing systemic inflammation. However, the effects of prebiotics such as xylooligosaccharides (XOS); probiotics such as Lactobacillus paracasei STII01 HP4, and synbiotics on metabolic and LV function in obese insulin-resistant rats have not been investigated...
June 12, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28606462/growing-literature-but-limited-evidence-a-systematic-review-regarding-prebiotic-and-probiotic-interventions-for-those-with-traumatic-brain-injury-and-or-posttraumatic-stress-disorder
#10
Lisa A Brenner, Kelly A Stearns-Yoder, Adam S Hoffberg, Molly E Penzenik, Amy J Starosta, Theresa D Hernández, Daniel A Hadidi, Christopher A Lowry
Traumatic brain injury (TBI) is highly prevalent among a wide-range of populations, including civilians, military personnel, and Veterans. TBI sequelae may be further exacerbated by symptoms associated with frequently occurring co-morbid psychiatric conditions including posttraumatic stress disorder (PTSD). This is particularly true among the population of military personnel from recent conflicts in Iraq and Afghanistan with a history of mild TBI (mTBI) and PTSD. The need for efficacious treatments for TBI and co-morbid PTSD is significant, and evidence-based interventions for these frequently co-occurring conditions are limited...
June 9, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28602989/brachybacterium-sp-ch-kov3-isolated-from-an-oil-polluted-environment-a-new-producer-of-levan
#11
Aleksandra Djurić, Gordana Gojgić-Cvijović, Dragica Jakovljević, Branka Kekez, Jovana Stefanović Kojić, Maija-Liisa Mattinen, Inka Elina Harju, Miroslav M Vrvić, Vladimir P Beškoski
Various microorganisms isolated from polluted environments, such as Pseudomonas sp. and Micrococcus sp. can synthesize exopolysaccharides (EPSs) which are natural, non-toxic and biodegradable polymers. EPSs play a key role in protection of microbial cells under various external influences. For humans, these substances have potential use in many industries. EPSs can be applied as a flavor or a fragrance carrier, an emulsifier, a stabilizer, a prebiotic, an antioxidant or an antitumor agent. In this study, we characterized an environmental microorganism that produces EPS, optimized EPS production by this strain and characterized the EPS produced...
June 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28602521/gut-microbiota-dysbiosis-in-postweaning-piglets-understanding-the-keys-to-health
#12
REVIEW
Raphaële Gresse, Frédérique Chaucheyras-Durand, Mickaël Alain Fleury, Tom Van de Wiele, Evelyne Forano, Stéphanie Blanquet-Diot
Weaning is a critical event in the pig's life cycle, frequently associated with severe enteric infections and overuse of antibiotics; this raises serious economic and public health concerns. In this review, we explain why gut microbiota dysbiosis, induced by abrupt changes in the diet and environment of piglets, emerges as a leading cause of post-weaning diarrhea, even if the exact underlying mechanisms remain unclear. Then, we focus on nonantimicrobial alternatives, such as zinc oxide, essential oils, and prebiotics or probiotics, which are currently evaluated to restore intestinal balance and allow a better management of the crucial weaning transition...
June 8, 2017: Trends in Microbiology
https://www.readbyqxmd.com/read/28600550/permeability-driven-selection-in-a-semi-empirical-protocell-model-the-roots-of-prebiotic-systems-evolution
#13
Gabriel Piedrafita, Pierre-Alain Monnard, Fabio Mavelli, Kepa Ruiz-Mirazo
The origin-of-life problem has been traditionally conceived as the chemical challenge to find the type of molecule and free-solution reaction dynamics that could have started Darwinian evolution. Different autocatalytic and 'self-replicative' molecular species have been extensively investigated, together with plausible synthetic pathways that might have led, abiotically, to such a minimalist scenario. However, in addition to molecular kinetics or molecular evolutionary dynamics, other physical and chemical constraints (like compartmentalization, differential diffusion, selective transport, osmotic forces, energetic couplings) could have been crucial for the cohesion, functional integration, and intrinsic stability/robustness of intermediate systems between chemistry and biology...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28596023/prebiotic-reduces-body-fat-and-alters-intestinal-microbiota-in-children-with-overweight-or-obesity
#14
Alissa C Nicolucci, Megan P Hume, Inés Martínez, Shyamchand Mayengbam, Jens Walter, Raylene A Reimer
BACKGROUND & AIMS: It might be possible to manipulate the intestinal microbiota with prebiotics or other agents to prevent or treat obesity. However, little is known about the ability of prebiotics to specifically modify gut microbiota in children with overweight/obesity or reduce body weight. We performed a randomized controlled trial to study the effects of prebiotics on body composition, markers of inflammation, bile acids in fecal samples, and composition of the intestinal microbiota in children with overweight or obesity...
June 3, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28589103/effect-of-symbiotic-supplementation-on-glycemic-control-lipid-profiles-and-microalbuminuria-in-patients-with-non-obese-type-2-diabetes-a-randomized-double-blind-clinical-trial
#15
Zarin Sadat Ebrahimi, Ensieh Nasli-Esfahani, Azadeh Nadjarzade, Hassan Mozaffari-Khosravi
BACKGROUND: The prevalent raise of type 2 diabetes (T2D) around the globe, are creating higher risk for cardiovascular diseases (CVDs) and increasing strain on each country's health care budget in the world. Microalbuminuria has appeared as a key parameter in diabetic patients. Microalbuminuria is also related to increased cardiovascular morbidity in people who are non-obese diabetic. Some studies have suggested that consumption of symbiotic foods might help improve the metabolic profile, inflammatory factors and biomarkers of oxidative stress...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28589039/gum-arabic-reduces-c-reactive-protein-in-chronic-kidney-disease-patients-without-affecting-urea-or-indoxyl-sulfate-levels
#16
Sarra Elamin, Mariam J Alkhawaja, Amina Y Bukhamsin, Mohamed A S Idris, Muntasir M Abdelrahman, Nasrulla K Abutaleb, Abdulrahman A Housawi
INTRODUCTION: Gum Arabic (GA) is a complex polysaccharide with proven prebiotic properties and potentially beneficial systemic effects. METHODS: We randomly allocated 36 chronic kidney disease (CKD) patients to receive 10, 20, or 40 grams daily of GA for four weeks and studied the systemic effects of this intervention. RESULTS: Thirty participants completed the study with baseline glomerular filtration rate 29.1 ± 9.9 mL/min/1.7 m(2)...
2017: International Journal of Nephrology
https://www.readbyqxmd.com/read/28588563/insight-into-potential-probiotic-markers-predicted-in-lactobacillus-pentosus-mp-10-genome-sequence
#17
Hikmate Abriouel, Beatriz Pérez Montoro, Carlos S Casimiro-Soriguer, Antonio J Pérez Pulido, Charles W Knapp, Natacha Caballero Gómez, Sonia Castillo-Gutiérrez, María D Estudillo-Martínez, Antonio Gálvez, Nabil Benomar
Lactobacillus pentosus MP-10 is a potential probiotic lactic acid bacterium originally isolated from naturally fermented Aloreña green table olives. The entire genome sequence was annotated to in silico analyze the molecular mechanisms involved in the adaptation of L. pentosus MP-10 to the human gastrointestinal tract (GIT), such as carbohydrate metabolism (related with prebiotic utilization) and the proteins involved in bacteria-host interactions. We predicted an arsenal of genes coding for carbohydrate-modifying enzymes to modify oligo- and polysaccharides, such as glycoside hydrolases, glycoside transferases, and isomerases, and other enzymes involved in complex carbohydrate metabolism especially starch, raffinose, and levan...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28587263/iron-for-africa-report-of-an-expert-workshop
#18
Martin N Mwangi, Kamija S Phiri, Abdelhak Abkari, Mory Gbané, Raphaelle Bourdet-Sicard, Véronique Azaïs Braesco, Michael B Zimmermann, Andrew M Prentice
Scientific experts from nine countries gathered to share their views and experience around iron interventions in Africa. Inappropriate eating habits, infections and parasitism are responsible for significant prevalence of iron deficiency, but reliable and country-comparable prevalence estimates are lacking: improvements in biomarkers and cut-offs values adapted to context of use are needed. Benefits of iron interventions on growth and development are indisputable and outweigh risks, which exist in populations with a high infectious burden...
June 5, 2017: Nutrients
https://www.readbyqxmd.com/read/28587245/has-inositol-played-any-role-in-the-origin-of-life
#19
Adolfo Saiardi
Phosphorus, as phosphate, plays a paramount role in biology. Since phosphate transfer reactions are an integral part of contemporary life, phosphate may have been incorporated into the initial molecules at the very beginning. To facilitate the studies into early phosphate utilization, we should look retrospectively to phosphate-rich molecules present in today's cells. Overlooked by origin of life studies until now, inositol and the inositol phosphates, of which some species possess more phosphate groups that carbon atoms, represent ideal molecules to consider in this context...
June 5, 2017: Life
https://www.readbyqxmd.com/read/28587172/the-rising-tide-of-antimicrobial-resistance-in-aquaculture-sources-sinks-and-solutions
#20
REVIEW
Joy E M Watts, Harold J Schreier, Lauma Lanska, Michelle S Hale
As the human population increases there is an increasing reliance on aquaculture to supply a safe, reliable, and economic supply of food. Although food production is essential for a healthy population, an increasing threat to global human health is antimicrobial resistance. Extensive antibiotic resistant strains are now being detected; the spread of these strains could greatly reduce medical treatment options available and increase deaths from previously curable infections. Antibiotic resistance is widespread due in part to clinical overuse and misuse; however, the natural processes of horizontal gene transfer and mutation events that allow genetic exchange within microbial populations have been ongoing since ancient times...
June 1, 2017: Marine Drugs
keyword
keyword
26372
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"