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Vitamin E

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https://www.readbyqxmd.com/read/29792987/the-rheological-and-textural-characterization-of-soluplus-%C3%A2-vitamin-e-composites
#1
Ahmad Salawi, Sami Nazzal
Soluplus® is a graft amphiphilic copolymer that is frequently used as an excipient in solid dosage forms as a dissolution and a solubility enhancer. We discovered that Soluplus® can be dissolved in vitamin E. The result is a tacky and highly adhesive material. Our research objective was to evaluate the rheological, adhesive, and textural properties of the Soluplus® /Vitamin E composites. In this study, Soluplus® was dissolved under heat in vitamin E at increasing concentrations from 0 to 40% (by weight)...
May 21, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29792083/a-systematic-review-and-meta-analysis-of-the-association-between-vitamin-a-intake-serum-vitamin-a-and-risk-of-liver-cancer
#2
Nattawut Leelakanok, Ronilda R D'Cunha, Grerk Sutamtewagul, Marin L Schweizer
BACKGROUND: Previous evidence supports that vitamin A decreases the risk of several types of cancer. However, the association between vitamin A and liver cancer is inconclusive. AIM: This systematic review and meta-analysis summarizes the existing literature, discussing the association between vitamin A intake, serum vitamin A, and liver cancer in adult populations. METHODS: A systematic literature review was performed by searching the EMBASE, PubMed, Scopus and International Pharmaceutical Abstract databases using terms related to vitamin A (e...
January 1, 2018: Nutrition and Health
https://www.readbyqxmd.com/read/29791721/persistence-of-treatment-with-biologics-for-patients-with-psoriasis-a-real-world-analysis-of-16-545-biologic-na%C3%A3-ve-patients-from-the-french-national-health-insurance-database-sniiram
#3
E Sbidian, M Mezzarobba, A Weill, J Coste, J Rudant
BACKGROUND: Long-term clinical effectiveness of biologics in psoriasis is needed. OBJECTIVES: We aimed to assess the long-term persistence of biologics used to treat psoriasis in a real-life setting. METHODS: All adults with psoriasis having been registered in the French national health insurance database (SNIIRAM) between 2008 and 2016 were eligible for inclusion. Psoriasis was defined as the fulfilment of at least two prescriptions for topical formulations of vitamin D derivative within a two-year period...
May 23, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29791675/development-of-a-diet-quality-index-adapted-for-pregnant-women
#4
Lívia Castro Crivellenti, Daniela Cristina Candelas Zuccolotto, Daniela Saes Sartorelli
OBJECTIVE: To develop a Diet Quality Index Adapted for Pregnant Women (IQDAG) and to evaluate its relation with the characteristics of women treated at the Brazilian Unified Health System. METHODS: The data on food intake come from a cross-sectional study carried out with 785 adult pregnant women in the city of Ribeirão Preto, state of São Paulo, Brazil, between 2011 and 2012. The index was based on the recommendations of the Brazilian Ministry of Health, previous national dietary indexes, and the new Dietary Guidelines for the Brazilian Population...
2018: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29791315/incidence-of-early-onset-sepsis-in-infants-born-to-women-with-clinical-chorioamnionitis
#5
Tara M Randis, Madeline Murguia Rice, Leslie Myatt, Alan T N Tita, Kenneth J Leveno, Uma M Reddy, Michael W Varner, John M Thorp, Brian M Mercer, Mara J Dinsmoor, Susan M Ramin, Marshall W Carpenter, Philip Samuels, Anthony Sciscione, Jorge E Tolosa, George Saade, Yoram Sorokin
OBJECTIVE: To determine the frequency of sepsis and other adverse neonatal outcomes in women with a clinical diagnosis of chorioamnionitis. METHODS: We performed a secondary analysis of a multi-center placebo-controlled trial of vitamins C/E to prevent preeclampsia in low risk nulliparous women. Clinical chorioamnionitis was defined as either the "clinical diagnosis" of chorioamnionitis or antibiotic administration during labor because of an elevated temperature or uterine tenderness in the absence of another cause...
May 23, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29790013/effect-of-photobiomodulation-670-nm-associated-with-vitamin-a-on-the-inflammatory-phase-of-wound-healing
#6
A N Otterço, P Brassolatti, A L M Andrade, L R S Avó, P S Bossini, N A E Parizotto
Wound healing is a complex biological process with specific phases. Photobiomodulation (PBM) decreases the inflammatory infiltrate, stimulating fibroblast proliferation and angiogenesis, and therefore, is indicated for wound healing. Vitamin A is used to reverse the inhibitory effects on wound healing and accelerate the healthy granulation tissue. The study aimed to evaluate the effect of topical vitamin A and PBM (GaAlAs) in inflammatory phase of cutaneous wounds. Forty Wistar male rats were separated into four groups: (1) control (CG); (2) laser group (LG) GaAlAs, 670 nm, 30 mW, energy per point of 0...
May 22, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29789712/distribution-and-determinants-of-retinol-in-norwegian-adolescents-and-its-relation-to-bone-mineral-density-the-troms%C3%A3-study-fit-futures
#7
M S W Teigmo, T E Gundersen, N Emaus, G Grimnes
BACKGROUND/OBJECTIVES: Sufficient vitamin A levels are important for many functions-and both too little and too much may have detrimental health effects. The aim of the study was to describe the distribution of retinol levels in Norwegian adolescents, the relation between lifestyle factors and retinol levels, and the relation between retinol levels and bone mineral density (BMD). SUBJECTS/METHODS: Serum retinol was measured in 414 girls and 474 boys aged 15-19 years, participating in the Tromsø Study: Fit Futures...
May 23, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29788957/endothelial-progenitor-cells-improve-the-therapeutic-effect-of-mesenchymal-stem-cell-sheets-on-irradiated-bone-defect-repair-in-a-rat-model
#8
Huan Liu, Yang Jiao, Wei Zhou, Shizhu Bai, Zhihong Feng, Yan Dong, Qian Liu, Xiaoke Feng, Yimin Zhao
BACKGROUND: The reconstruction of bone defects is often impaired by radiotherapy since bone quality is compromised by radiation. This study aims to investigate the therapeutic efficacy of the composite cell sheets-bone marrow mesenchymal stem cell (BMSC) sheets cocultured with endothelial progenitor cells (EPCs)-in the healing of irradiated bone defects and the biological effects of EPCs on the osteogenic properties of BMSC sheets. METHODS: BMSCs and EPCs were isolated from rat bone marrow...
May 22, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29788239/circulating-selenium-and-prostate-cancer-risk-a-mendelian-randomization-analysis
#9
James Yarmolinsky, Carolina Bonilla, Philip C Haycock, Ryan J Q Langdon, Luca A Lotta, Claudia Langenberg, Caroline L Relton, Sarah J Lewis, David M Evans, George Davey Smith, Richard M Martin
In the Selenium and Vitamin E Cancer Prevention Trial (SELECT), selenium supplementation (causing a median 114 μg/L increase in circulating selenium) did not lower overall prostate cancer risk, but increased risk of high-grade prostate cancer and type 2 diabetes. Mendelian randomization analysis uses genetic variants to proxy modifiable risk factors and can strengthen causal inference in observational studies. We constructed a genetic instrument comprising 11 single nucleotide polymorphisms robustly (P < 5 × 10-8) associated with circulating selenium in genome-wide association studies...
May 17, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29787748/vitamin-d-receptor-is-required-for-proliferation-migration-and-differentiation-of-epidermal-stem-cells-and-progeny-during-cutaneous-wound-repair
#10
Yuko Oda, Lizhi Hu, Thai Nguyen, Chak Fong, Jing Zhang, Pan Guo, Daniel D Bikle
Epidermal stem cells residing in the skin play an essential role in epidermal regeneration. When skin is injured, the stem cells are first activated to proliferate, and subsequently the progeny migrate and differentiate to regenerate the epidermis. Here, we demonstrate that the vitamin D receptor (VDR) is essential for these processes to occur. The requirement for VDR on epidermal stem cell function was revealed in conditional VDR knockout (cKO) mice, in which VDR was deleted from stem cells and progeny, and mice were maintained on a low calcium diet...
May 19, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29786697/imaging-glutathione-depletion-in-the-rat-brain-using-ascorbate-derived-hyperpolarized-mr-and-pet-probes
#11
Hecong Qin, Valerie N Carroll, Renuka Sriram, Javier E Villanueva-Meyer, Cornelius von Morze, Zhen Jane Wang, Christopher A Mutch, Kayvan R Keshari, Robert R Flavell, John Kurhanewicz, David M Wilson
Oxidative stress is a critical feature of several common neurologic disorders. The brain is well adapted to neutralize oxidative injury by maintaining a high steady-state concentration of small-molecule intracellular antioxidants including glutathione in astrocytes and ascorbic acid in neurons. Ascorbate-derived imaging probes for hyperpolarized 13 C magnetic resonance spectroscopy and positron emission tomography have been used to study redox changes (antioxidant depletion and reactive oxygen species accumulation) in vivo...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29785601/alteration-in-apoptotic-rate-of-testicular-cells-and-sperms-following-administration-of-bisphenol-a-bpa-in-wistar-albino-rats
#12
Seema Srivastava, Priya Gupta
The aim of the study was to evaluate the effect of Bisphenol A [BPA] widely used as a plasticizer in the formation of polycarbonate plastics and epoxy resins, exposure causing alteration in apoptosis rate, and protective effect of Vitamin E when supplemented with BPA orally. Adult male Wistar albino rats aged 3 months were randomly divided into seven groups: control (olive oil treated) BPA-treated (dose 5, 50,100 μg/100gmBW) and Vitamin E intervention group (dose 5, 50, 100 μg/100gmBW BPA+ Vitamin E dose 4 mg/100gmBW)...
May 21, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29784887/identification-of-the-thioredoxin-partner-of-vkor-in-mycobacterial-disulfide-bond-formation
#13
Na Ke, Cristina Landeta, Xiaoyun Wang, Dana Boyd, Markus Eser, Jon Beckwith
Disulfide bonds influence stability and activity of many proteins. In Escherichia coli the DsbA and DsbB enzymes promote disulfide bond formation. Other bacteria, including the Actinobacteria, use instead of DsbB the enzyme VKOR (Vitamin K Epoxide Reductase), which is found either fused to or encoded in the same operon as a dsbA -like protein. Mycobacterium tuberculosis and other gram-positive Actinobacteria secrete to the cell envelope many proteins with even numbers of cysteines. These organisms have predicted oxidoreductases and VKOR orthologs...
May 21, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29784551/residual-byproducts-of-peroxide-crosslinked-vitamin-e-blended-ultrahigh-molecular-weight-polyethylene
#14
David A Bichara, Caitlin C O'Brien, Brinda N Doshi, Gunnlaugur P Nielsen, Ebru Oral, Orhun K Muratoglu
BACKGROUND: Wear resistance of ultrahigh molecular weight polyethylene (UHMWPE) is improved via ionizing radiation crosslinking and subsequent high temperature melting for improved toughness. Our group has previously reported that crosslinking can also be achieved chemically using organic peroxides. However, volatile peroxide byproducts are generated during consolidation. The purpose of this study was to quantify elution of volatile peroxide byproducts from UHMWPE before and after in vivo implantation, and to determine their effects on local tissues...
March 13, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29782992/single-ultra-high-dose-cholecalciferol-to-prevent-vitamin-d-deficiency-in-pediatric-hematopoietic-stem-cell-transplantation
#15
Gregory Wallace, Sonata Jodele, Kasiani C Myers, Christopher E Dandoy, Javier El-Bietar, Adam Nelson, Ashley Teusink-Cross, Pooja Khandelwal, Cynthia Taggart, Catherine M Gordon, Stella M Davies, Jonathan C Howell
BACKGROUND: Vitamin D (vitD) deficiency is prevalent among childhood hematopoietic stem cell transplantation (HSCT) recipients and associated with inferior transplant survival at 100 days after transplantation. Achieving and maintaining therapeutic vitD levels in HSCT recipients is extremely challenging in the first 3-6 months after transplant due to poor compliance in the setting of mucositis, and concomitant use of critical transplant drugs that interfere with vitD absorption. We sought to evaluate the safety and efficacy of a single, ultra-high dose of vitD given prior to childhood HSCT to maintain levels in a therapeutic range during the peri-transplantation period...
May 18, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29782253/-mineral-and-bone-disorders-in-chronic-heart-failure
#16
E V Reznik, I G Nikitin
In many patients, chronic heart failure (CHF) is associated with chronic kidney disease (CKD). Virtually all patients with terminal CKD and many patients with early CKD display various disorders of mineral and bone metabolism (MBM) related with all-cause mortality and high risk of cardiovascular complications. This review addressed disorders of mineral and bone metabolism in patients with CHF, including hypocalcemia, hyperphosphatemia, vitamin D insufficiency/deficiency, secondary hyperparathyroidism, changed levels of FGF23 and Klotho, osteoporosis, osteopenia, their clinical and prognostic significance, and possibilities of their correction...
2018: Kardiologiia
https://www.readbyqxmd.com/read/29782187/effects-of-maternal-vitamin-d-supplementation-on-the-maternal-and-infant-epigenome
#17
Cindy M Anderson, Shannon L Gillespie, Doria K Thiele, Jody L Ralph, Joyce E Ohm
INTRODUCTION: Mothers and infants are at high risk for inadequate vitamin D status. Mechanisms by which vitamin D may affect maternal and infant DNA methylation are poorly understood. OBJECTIVE: This study quantified the effects of vitamin D3 supplementation on DNA methylation in pregnant and lactating women and their breastfed infants. MATERIALS AND METHODS: In this randomized controlled pilot study, pregnant women received vitamin D3 400 international units (IU) (n = 6; control) or 3,800 IU (n = 7; intervention) daily from late second trimester through 4-6 weeks postpartum...
May 21, 2018: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29780162/dietary-antioxidant-intake-and-the-risk-of-developing-barrett-s-oesophagus-and-oesophageal-adenocarcinoma
#18
James H-E Kang, Robert Luben, Leo Alexandre, Andrew R Hart
BACKGROUND: We investigated in a cohort study, for the first time using 7-day food diaries (7-DFDs), for age-dependent inverse associations with antioxidants, which have anti-carcinogenic properties, and development of Barrett's oesophagus (BO) and oesophageal adenocarcinoma (OAC). METHODS: A total of 24,068 well individuals completed 7-DFDs and donated blood. Vitamins C and E, carotenes, zinc and selenium intakes, and plasma vitamin C were measured. Participants were monitored for 15 years for BO and OAC...
May 21, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29779954/construction-of-fluorescent-analogs-to-follow-the-uptake-and-distribution-of-cobalamin-vitamin-b-12-in-bacteria-worms-and-plants
#19
Andrew D Lawrence, Emi Nemoto-Smith, Evelyne Deery, Joseph A Baker, Susanne Schroeder, David G Brown, Jennifer M A Tullet, Mark J Howard, Ian R Brown, Alison G Smith, Helena I Boshoff, Clifton E Barry, Martin J Warren
Vitamin B12 is made by only certain prokaryotes yet is required by a number of eukaryotes such as mammals, fish, birds, worms, and Protista, including algae. There is still much to learn about how this nutrient is trafficked across the domains of life. Herein, we describe ways to make a number of different corrin analogs with fluorescent groups attached to the main tetrapyrrole-derived ring. A further range of analogs were also constructed by attaching similar fluorescent groups to the ribose ring of cobalamin, thereby generating a range of complete and incomplete corrinoids to follow uptake in bacteria, worms, and plants...
April 28, 2018: Cell Chemical Biology
https://www.readbyqxmd.com/read/29778886/perspectives-of-uv-nowcasting-to-monitor-personal-pro-health-outdoor-activities
#20
Janusz W Krzyścin, Aleksandra Lesiak, Joanna Narbutt, Piotr Sobolewski, Jakub Guzikowski
Nowcasting model for online monitoring of personal outdoor behaviour is proposed. It is envisaged that it will provide an effective e-tool used by smartphone users. The model could estimate maximum duration of safe (without erythema risk) outdoor activity. Moreover, there are options to estimate duration of sunbathing to get adequate amount of vitamin D3 and doses necessary for the antipsoriatic heliotherapy. The application requires information of starting time of sunbathing and the user's phototype. At the beginning the user will be informed of the approximate duration of sunbathing required to get the minimum erythemal dose, adequate amount of vitamin D3 , and the dose necessary for the antipsoriatic heliotherapy...
May 14, 2018: Journal of Photochemistry and Photobiology. B, Biology
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