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Vitamin E

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https://www.readbyqxmd.com/read/28531922/protective-effect-of-averrhoa-bilimbi-l-fruit-extract-on-ulcerative-colitis-in-wistar-rats-via-regulation-of-inflammatory-mediators-and-cytokines
#1
Jagadish Kumar Suluvoy, Sakthivel K M, Guruvayoorappan C, Berlin Grace V M
Ulcerative Colitis (UC) is a lingering type of Inflammatory Bowel Disease (IBD) which affects the colon mucosa. Ulcerative colitis is majorly associated with oxidative stress and inflammation in colon tissue leading to damage. Averrhoa bilimbi L. fruit is rich in antioxidant phytochemicals including Vitamin C. In the current research, we have evaluated the defence mechanism of Averrhoa bilimbi L. on Ulcerative Colitis (UC). Male wistar rats were treated with Averrhoa bilimbi L. fruit extract (50mg/kg/bwt and 100mg/kg/bwt) and a standard drug Sulfasalazine (100mg/kg/bwt) for 6 consecutive days via intra peritoneally...
May 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28531918/protective-effect-of-ethanolic-extract-of-urtica-urens-l-against-the-toxicity-of-imidacloprid-on-bone-remodeling-in-rats-and-antioxidant-activities
#2
Massara Mzid, Riadh Badraoui, Sameh Ben Khedir, Zouheir Sahnoun, Tarek Rebai
Imidacloprid (IMI) is very harmful to human health and cause problems. Recently, plants have been considered as potential agents for protection against these disorders. Urtica urens L. (UU) is very useful for relieving rheumatic pains and there is no scientific evidence justifying its use, which lets us think of its direct effect on the bone. This study aimed to investigate the protective effect of UU against toxicity effects of IMI in female rat. Rats were divided into control group, 3 groups treated with IMI at 50, 200 or 300mg/kg/day and 3 groups co-treated with IMI (50, 200 or 300mg/kg/day)+100mg/kg/day of UU...
May 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28531643/lipid-based-nutrient-supplements-containing-vitamins-and-minerals-attenuate-renal-electrolyte-loss-in-hiv-aids-patients-starting-antiretroviral-therapy-a-randomized-controlled-trial-in-zambia
#3
D Munkombwe, T L Muungo, C Michelo, P Kelly, S Chirwa, S Filteau
BACKGROUND & AIMS: Advanced HIV infection combined with undernutrition and antiretroviral therapy (ART) places HIV/AIDS patients at high risk of electrolyte abnormalities and increased morbidity and mortality. Here, in a sub-study of a large published randomized trial, we evaluated if nutritional supplements will help curtail renal electrolyte loss in HIV/AIDS patients starting ART. METHODS: 130 malnourished HIV-positive patients referred for ART received lipid-based nutrient supplements alone (LNS, n = 63) or together with vitamins and minerals (LNS-VM, n = 67)...
June 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531130/comparative-safety-and-efficacy-profile-of-a-novel-oil-in-water-vaccine-adjuvant-comprising-vitamins-a-and-e-and-a-catechin-in-protective-anti-influenza-immunity
#4
Sapna Patel, Yasser Faraj, Debra K Duso, William W Reiley, Erik A Karlsson, Stacey Schultz-Cherry, Michael Vajdy
Non-replicating vaccines, such as those based on recombinant proteins, require adjuvants and delivery systems, which have thus far depended on mimicking pathogen danger signals and strong pro-inflammatory responses. In search of a safer and more efficacious alternative, we tested whether vaccinations with influenza recombinant hemagglutinin (HA) mixed with a novel vegetable oil in water emulsion adjuvant (Natural Immune-enhancing Delivery System, NIDS), based on the immune-enhancing synergy of vitamins A and E and a catechin, could protect against intra-nasal challenge with live influenza virus...
May 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28529085/variations-in-native-protein-glycation-and-plasma-antioxidants-in-several-birds-of-prey
#5
Tana Ingram, Jessica Zuck, Chad R Borges, Patrick Redig, Karen L Sweazea
Birds are an anomaly among vertebrates as they are remarkably long-lived despite having naturally high blood glucose and metabolic rates. For mammals, hyperglycemia leads to oxidative stress and protein glycation. In contrast, many studies have shown that domestic and wild birds are relatively resistant to these glucose-mediated pathologies. Surprisingly very little research has examined protein glycation in birds of prey, which by nature consume a diet high in protein and fat that promotes gluconeogenesis...
May 18, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28527581/nuclear-receptors-in-skeletal-homeostasis
#6
Hao Zuo, Yihong Wan
Nuclear receptors are a family of transcription factors that can be activated by lipophilic ligands. They are fundamental regulators of development, reproduction, and energy metabolism. In bone, nuclear receptors enable bone cells, including osteoblasts, osteoclasts, and osteocytes, to sense their dynamic microenvironment and maintain normal bone development and remodeling. Our views of the molecular mechanisms in this process have advanced greatly in the past decade. Drugs targeting nuclear receptors are widely used in the clinic for treating patients with bone disorders such as osteoporosis by modulating bone formation and resorption rates...
2017: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/28526926/higher-prevalence-of-vitamin-d-deficiency-in-german-pregnant-women-compared-to-non-pregnant-women
#7
Sandra Gellert, Alexander Ströhle, Norman Bitterlich, Andreas Hahn
PURPOSE: Adequate vitamin D status is crucial for normal development of the fetus and for maternal health. As data on vitamin D status (25-hydroxyvitamin D, 25(OH)D) in German women of different states of pregnancy were not available, this study compared the vitamin D status of German women in all trimesters of pregnancy with that of non-pregnant women. METHODS: The study sample of 858 women (18-45 years) was recruited from April 2013 to March 2015 as a part of the cross-sectional Germany-wide VitaMinFemin study...
May 19, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28526433/risk-of-low-birth-weight-and-micronutrient-deficiencies-in-neonates-from-mothers-after-gastric-bypass-a-case-control-study
#8
Geraldine Gascoin, Maxime Gerard, Agnès Sallé, Guillaume Becouarn, Stephanie Rouleau, Loïc Sentilhes, Régis Coutant
BACKGROUND: An increased risk of small-for-gestational-age infants after maternal bariatric surgery has been shown. The risk of micronutrients deficiencies in these neonates is unclear. OBJECTIVE: To screen for micronutrients deficiencies in newborns of mothers with gastric bypass. SETTINGS: University hospital in Angers, France. METHODS: This study compared the clinical and cord blood biological characteristics of 56 newborns of mothers with prior Roux-en-Y gastric bypass (RYGB) and 56 newborns of nonobese healthy mothers after normal pregnancy (controls), followed between January 3, 2008 and October 31, 2012...
March 27, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28526387/adequacy-of-nutrient-intake-in-women-with-restrictive-anorexia-nervosa
#9
Chiara Chiurazzi, Iolanda Cioffi, Carmela De Caprio, Emilia De Filippo, Maurizio Marra, Rosa Sammarco, Maria Luisa Di Guglielmo, Franco Contaldo, Fabrizio Pasanisi
OBJECTIVE: The aim of the present study was to assess energy and nutrient intake in a group of women with restrictive AN (r-AN) compared with a control group. METHODS: Thirteen r-AN patients and 13 healthy female controls completed 7-d food records. Intake of macro- and micronutrients was compared between the two groups as well as to the Dietary Reference Intake for the Italian Population (LARN) for specific ages. Additionally, the r-AN patients underwent indirect calorimetry for measuring resting energy expenditure (REE)...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28526374/impact-of-high-dose-vitamin-d3-on-plasma-free-25-hydroxyvitamin-d-concentrations-and-antimicrobial-peptides-in-critically-ill-mechanically-ventilated-adults
#10
Jenny E Han, Jessica A Alvarez, Jennifer L Jones, Vin Tangpricha, Mona A Brown, Li Hao, Lou Ann S Brown, Greg S Martin, Thomas R Ziegler
OBJECTIVES: High-dose vitamin D3 increases plasma total 25-hydroxyvitamin D [25(OH)D] in critically ill, ventilated patients; however, to our knowledge, the effect on plasma levels of free (nonprotein-bound) 25(OH)D has not been investigated in critical illness. Moreover, the relationship of free 25(OH)D and the regulation of endogenous antimicrobial peptides (AMPs) remains unknown. The aims of this study were to determine in critically ill adults with respiratory failure the effect of previous high-dose regimens of vitamin D3 on free 25(OH)D concentrations, the relationship of free 25(OH)D with circulating cathelicidin (LL-37) and human beta-defensin-2 (hBD-2), and the associations between plasma levels of free 25(OH)D and these AMPs to alveolar macrophage phagocytosis function...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28526159/anticoagulation-and-neuraxial-peripheral-anesthesia
#11
REVIEW
Mudit Kaushal, Ryan E Rubin, Alan D Kaye, Karina Gritsenko
Novel anticoagulants (NAGs) have emerged as the preferred alternatives to vitamin K antagonists. In patients being considered for regional anesthesia, these drugs present a layer of complexity in the preprocedure evaluation. There are no established tests to monitor anticoagulant activity and our experience is short with these drugs. These authors believe it is important to review the relevant hematology, orthopedics, and anesthesiology literature to provide a valuable reference for the clinician who is met with these challenges...
June 2017: Anesthesiology Clinics
https://www.readbyqxmd.com/read/28522774/acenocoumarol-as-a-risk-factor-for-calciphylaxis-a-feature-clinicians-should-be-aware-of
#12
E F E Wenstedt, C J Huysentruyt, C J A M Konings
In contrast with uraemic calciphylaxis in end-stage renal disease, causes of and risk factors for non-uraemic calciphylaxis are relatively unknown to clinicians and have yet to become fully established. This report describes a case of non-uraemic calciphylaxis, in which the use of acenocoumarol might have been a risk factor. It is important to raise awareness about this association among clinicians, as vitamin K antagonists have to be stopped for an optimal treatment of this severe condition.
May 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/28521878/combining-a-nontargeted-and-targeted-metabolomics-approach-to-identify-metabolic-pathways-significantly-altered-in-polycystic-ovary-syndrome
#13
Alice Y Chang, Antigoni Z Lalia, Gregory D Jenkins, Tumpa Dutta, Rickey E Carter, Ravinder J Singh, K Sreekumaran Nair
OBJECTIVE: Polycystic ovary syndrome (PCOS) is a condition of androgen excess and chronic anovulation frequently associated with insulin resistance. We combined a nontargeted and targeted metabolomics approach to identify pathways and metabolites that distinguished PCOS from metabolic syndrome (MetS). METHODS: Twenty obese women with PCOS were compared with 18 obese women without PCOS. Both groups met criteria for MetS but could not have diabetes mellitus or take medications that treat PCOS or affect lipids or insulin sensitivity...
June 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28521827/antioxidant-activity-acetylcholinesterase-inhibitory-potential-and-phytochemical-analysis-of-sarcocephalus-latifolius-sm-bark-used-in-traditional-medicine-in-sudan
#14
Alsiddig Osama, Sufyan Awadelkarim, Amna Ali
BACKGROUND: Sarcocephalus latifolius is used as a traditional medicine for curing many diseases in Sudan. The main objective of the current study was to determine the antioxidant activity and acetylcholinesterase inhibition (AChEI) of S. latifolius, and to estimate its total phenolic and flavonoid contents. METHODS: Antioxidant activity of the tested plant extracts was carried out by determining their ability to scavenge the 2,2-diphenyl-1-picryl hydrazyl (DPPH) free radical...
May 18, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28521578/improved-photostability-and-cytotoxic-effect-of-coenzyme-q10-by-its-association-with-vitamin-e-acetate-in-polymeric-nanocapsules
#15
Natháli S Pegoraro, Juliane Mattiazzi, Elita F da Silveira, Juliana H Azambuja, Elizandra Braganhol, Letícia Cruz
The present study showed the development of nanocapsules containing the association of the coenzyme Q10 and vitamin E acetate and the evaluation of their effect on in vitro cells culture of malignant glioma and melanoma. In order to investigate if nanocapsules are able to protect coenzyme Q10 from degradation under UVC radiation, a photostability study was carried out. For this, three concentrations of vitamin E acetate were evaluated (1, 2 or 3%). Nanocapsules presented suitable physicochemical characteristics and were able to protect coenzyme Q10 from photodegradation...
May 18, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28521540/cost-effectiveness-analysis-of-rivaroxaban-for-treatment-and-secondary-prevention-of-venous-thromboembolism-in-the-netherlands
#16
Marieke Heisen, Maarten J Treur, Harald E Heemstra, Eric B W Giesen, Maarten J Postma
BACKGROUND: Until recently, standard treatment of venous thromboembolism (VTE) concerned a combination of short-term low-molecular-weight heparin (LMWH) and long-term vitamin-K antagonist (VKA). Risk of bleeding and the requirement for regular anticoagulation monitoring are, however, limiting their use. Rivaroxaban is a novel oral anticoagulant associated with a significantly lower risk of major bleeds (hazard ratio 0.54, 95% confidence interval 0.37-0.79) compared to LMWH/VKA therapy and does not require regular anticoagulation monitoring...
May 18, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28520939/dietary-intake-of-antioxidant-vitamins-and-carotenoids-and-risk-of-developing-active-tuberculosis-in-a-prospective-population-based-cohort
#17
Avril Z Soh, Cynthia B E Chee, Yee-Tang Wang, Jian-Min Yuan, Woon-Puay Koh
Antioxidants may protect against oxidative stress, which is associated with tuberculosis disease. However, direct evidence for the protective association between dietary antioxidants and tuberculosis incidence in humans has been lacking. The relation between intake of antioxidant vitamins (A, C, D, E) and individual carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein) and tuberculosis incidence was examined in the Singapore Chinese Health Study, a prospective cohort of 63,257 adults 45-74 years old enrolled during 1993-1998...
May 18, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28518221/micronutrient-supplementation-in-adults-with-hiv-infection
#18
REVIEW
Marianne E Visser, Solange Durao, David Sinclair, James H Irlam, Nandi Siegfried
BACKGROUND: Micronutrient deficiencies are common among adults living with HIV disease, particularly in low-income settings where the diet may be low in essential vitamins and minerals. Some micronutrients play critical roles in maintenance of the immune system, and routine supplementation could therefore be beneficial. This is an update of a Cochrane Review previously published in 2010. OBJECTIVES: To assess whether micronutrient supplements are effective and safe in reducing mortality and HIV-related morbidity of HIV-positive adults (excluding pregnant women)...
May 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28516066/the-alpha-tocopherol-form-of-vitamin-e-boosts-elastase-activity-of-human-pmns-and-their-ability-to-kill-streptococcus-pneumoniae
#19
Elsa N Bou Ghanem, James N Lee, Basma H Joma, Simin N Meydani, John M Leong, Alexander Panda
Despite the availability of vaccines, Streptococcus pneumoniae remains a leading cause of life-threatening infections, such as pneumonia, bacteremia and meningitis. Polymorphonuclear leukocytes (PMNs) are a key determinant of disease course, because optimal host defense requires an initial robust pulmonary PMN response to control bacterial numbers followed by modulation of this response later in infection. The elderly, who manifest a general decline in immune function and higher basal levels of inflammation, are at increased risk of developing pneumococcal pneumonia...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28515377/high-fat-diet-increases-phospholipid-peroxidation-in-the-liver-of-mature-fischer-344-rats
#20
Saki Hayasaka, Fumiko Kimura, Shunji Kato, Naoki Shimizu, Junya Ito, Oki Higuchi, Katsuhiro Izumisawa, Teruo Miyazawa, Kiyotaka Nakagawa
Phospholipid peroxidation is considered to be involved in the pathophysiology of various diseases. While dietary antioxidants are believed to help prevent these diseases via inhibition of phospholipid peroxidation, further evaluation is needed to prove this hypothesis. For this, it is crucial to establish an animal model with accelerated phospholipid peroxidation. In this study, we hypothesized that a combination of aging and high-fat diet feeding may accelerate phospholipid peroxidation in vivo. High-fat diets were fed to mature and juvenile Fischer 344 rats for 12 weeks...
May 17, 2017: Journal of Oleo Science
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