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Vitamin E

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https://www.readbyqxmd.com/read/28442557/high-phosphate-induces-a-pro-inflammatory-response-by-vascular-smooth-muscle-cells-modulation-by-vitamin-d-derivatives
#1
Julio M Martínez-Moreno, Carmen Herencia, Addy Montes de Oca, Juan M Díaz-Tocados, Noemi Vergara, Mª José Gomez, Silvia D López-Argüello, Antonio Camargo, Esther Peralbo-Santaella, Maria E Rodríguez-Ortiz, Antonio Canalejo, Mariano Rodriguez, Juan J Muñoz-Castañeda, Yolanda Yolanda Almaden
In chronic kidney disease patients, high phosphate (HP) levels are associated to cardiovascular disease, the major cause of morbidity and mortality. Since serum phosphate has been independently correlated with inflammation, the present study aimed to investigate an independent direct effect of HP as a pro-inflammatory factor in VSMCs. A possible modulatory effect of vitamin D was also investigated. The study was performed in an in vitro model of human aortic smooth muscle cells (HASMCs). Incubation of cells in a HP (3...
April 25, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28442045/lower-dietary-n-6-n-3-ratio-and-high-dose-vitamin-e-supplementation-improve-sperm-morphology-and-oxidative-stress-in-boars
#2
Qing Liu, Yuanfei Zhou, Runjia Duan, Hongkui Wei, Siwen Jiang, Jian Peng
A 2×2 factorial experiment (10 boars per treatment) was conducted for 16 weeks to evaluate the effects of the dietary n-6:n-3 ratio (14:1 vs 6:1) and vitamin E (200 vs 400mg kg(-1)) on boar sperm morphology and oxidative stress. Sperm mitochondrial membrane potential (MMP), reactive oxygen species (ROS), DNA damage (8-hydroxydeoxyguanosine; 8-OHdG), seminal lipoperoxidation (malondialdehyde; MDA) and antioxidant capacity in the serum, spermatozoa and seminal plasma were assessed as indicators of oxidative stress...
April 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28441999/vitamin-d-and-food-allergies-in-children-a-systematic-review-and-meta-analysis
#3
E K Willits, Z Wang, J Jin, B Patel, M Motosue, A Bhagia, J Almasri, P J Erwin, S Kumar, A Y Joshi
No abstract text is available yet for this article.
May 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28441982/25-hydroxyvitamin-d-biomarkers-of-eosinophilic-inflammation-and-airway-remodeling-in-children-with-newly-diagnosed-untreated-asthma
#4
Grazyna Sypniewska, Magdalena Krintus, Gabriele Fulgheri, Joanna Siodmiak, Magdalena Kuligowska-Prusinska, Beata Stepien-Jaszowska, Radosława Staszak-Kowalska, Anna Zawadzka-Krajewska, Szymon Kierat, Katarzyna Bergmann, Urszula Demkow
BACKGROUND: Low 25-hydroxyvitamin D (25[OH]D) and asthma development may be related to airway remodeling and eosinophilia. Periostin is proposed as a key molecule that links remodeling and eosinophilic inflammation. OBJECTIVE: We evaluated the association of 25(OH)D concentration with periostin, peripheral blood eosinophil counts, and immunoglobulin E (IgE) in children with newly diagnosed asthma. METHODS: The study included 150 children: 110 with atopic asthma and 40 constituted a reference group...
May 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28441630/winter-to-summer-change-in-vitamin-d-status-reduces-systemic-inflammation-and-bioenergetic-activity-of-human-peripheral-blood-mononuclear-cells
#5
Emily K Calton, Kevin N Keane, Raquel Raizel, Jordan Rowlands, Mario J Soares, Philip Newsholme
BACKGROUND: Vitamin D status [25(OH)D] has recently been reported to be associated with altered cellular bioenergetic profiles of peripheral blood mononuclear cells (PBMCs). No study has tracked the seasonal variation of 25(OH)D and its putative influence on whole body energy metabolism, cellular bioenergetic profiles, inflammatory markers and clinical chemistry. MATERIAL AND METHODS: Whole body energy metabolism and substrate utilisation were measured by indirect calorimetry...
April 13, 2017: Redox Biology
https://www.readbyqxmd.com/read/28441536/the-effect-of-forage-types-on-the-fatty-acid-profile-lipid-and-protein-oxidation-and-retail-colour-stability-of-muscles-from-white-dorper-lambs
#6
Gerlane F De Brito, Benjamin W B Holman, Shawn R McGrath, Michael A Friend, Remy van de Ven, David L Hopkins
The aim of this study was to evaluate the effect of different forage-types on lamb meat quality parameters. White Dorper lambs that had grazed five forage-types, were slaughtered commercially. At 24h post-mortem, the m. longissimus lumborum (LL) was removed from one side, sliced into three equal sub-samples, vacuum packaged and assigned to ageing periods (5, 12 or 40days); the other side of LL was aged for 5days. The m. adductor femoris was used for fatty acid analysis. Lambs fed chicory+arrowleaf clover had the highest concentration of health claimable omega-3 fatty acids and the lowest omega-6:omega-3 fatty acid ratio...
April 4, 2017: Meat Science
https://www.readbyqxmd.com/read/28440717/serum-carotenoid-interactions-in-premenopausal-women-reveal-%C3%AE-carotene-is-negatively-impacted-by-body-fat
#7
Emily Taylor Nuss, Ashley R Valentine, Zhumin Zhang, HuiChuan Jennifer Lai, Sherry A Tanumihardjo
Increasing body mass indices (BMIs) across the globe reflect pandemic shifts towards habitual positive energy imbalances. Excess body fat in individuals is often associated with high-energy and high-fat diets scanty in fresh produce. Carotenoids are fat-soluble pigments plentiful in many fruits and vegetables. They are well-known for provitamin A and antioxidant functions, but little research has been done related to carotenoid-body mass interactions. Serum carotenoids were analyzed relative to body fat to determine correlations between major serum carotenoids, retinol, BMI, fat mass, and lean mass...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28438040/semi-preparative-hplc-purification-of-%C3%AE-tocotrienol-%C3%AE-t3-from-elaeis-guineensis-jacq-and-bixa-orellana-l-and-evaluation-of-its-in-vitro-anticancer-activity-in-human-a375-melanoma-cells
#8
Giangiacomo Beretta, Fabrizio Gelmini, Fabrizio Fontana, Roberta Manuela Moretti, Marina Montagnani Marelli, Patrizia Limonta
In this work, we report a rapid and convenient HPLC-UV-DAD method for the isolation of δ-T3 on semi-preparative scale from two different vitamin E rich processed, commercially available products obtained from the fruits of Elaeis guineensis Jacq. (oil palm) and from the seeds of Bixa orellana L. (achiote tree). Chromatography was run using reverse phase (RP) C-18 columns and HPLC-grade acetonitrile as mobile phase. The purity of the isolated δ-T3, assessed by GC-MS and (1)H NMR was above 98%. The δ-T3 cytotoxic activity found in vitro against the proliferation of human A375 melanoma cells compared to that of the other δ-T3 free tocols mixture suggest its primary role in the experimental anticancer activity observed for palm oil derived products...
April 24, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28436273/proteome-analysis-of-sheep-b-lymphocytes-in-the-course-of-bovine-leukemia-virus-induced-leukemia
#9
Michal Reichert
Presented are the results of a study of the expression pattern of different proteins in the course of bovine leukemia virus-induced leukemia in experimental sheep and I discuss how the obtained data may be useful in gaining a better understanding of the pathogenesis of the disease, diagnosis, and for the selection of possible therapeutic targets. In cattle, the disease is characterized by life-long persistent lymphocytosis leading to leukemia/lymphoma in about 5% of infected animals. In sheep, as opposed to cattle, the course of the disease is always fatal and clinical symptoms usually occur within a three-year period after infection...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28436039/nutrient-retention-values-and-cooking-yield-factors-for-three-south-african-lamb-and-mutton-cuts
#10
Salomina M van Heerden, Phillip E Strydom
BACKGROUND: Nutrient content of raw and cooked foods is important for formulation healthy diets. The retention of nutrients during cooking can be influenced by various factors including animal age, carcass characteristics and cooking method and these factors are often unique to specific countries. We studied the effects of animal age (lamb and mutton), carcass cut (shoulder, loin and leg) combined with cooking method (moist-heat and dry-heat) on yield and nutrient retention of selected nutrients of South African sheep carcasses...
April 23, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28436027/production-and-characterization-of-active-recombinant-human-factor-ii-with-consistent-sialylation
#11
Jeong H Lee, Jason Reier, Kelley M Heffner, Christopher Barton, David Spencer, Albert E Schmelzer, Raghavan Venkat
Coagulation factor II (prothrombin; FII) is the pre-proteolyzed precursor to thrombin in the coagulation cascade. It has ten sites of gamma-carboxylation, which are required for its bioactivity, and is N-glycosylated at three of four putative sites. Production of recombinant human FII (rhFII) using a platform fed-batch process designed for monoclonal antibody production resulted in low levels of gamma-carboxylation and sialylation. There have not been any prior reports of successful process development and clinical manufacture of rhFII with optimal, consistent gamma-carboxylation and sialylation...
April 24, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28435534/antioxidant-properties-of-novel-dimers-derived-from-natural-%C3%AE-elemene-through-inhibiting-h2o2-induced-apoptosis
#12
Jichao Chen, Ruifan Wang, Tianyu Wang, Qilong Ding, Aliahmad Khalil, Shengtao Xu, Aijun Lin, Hequan Yao, Weijia Xie, Zheying Zhu, Jinyi Xu
A series of novel β-elemene dimer derivatives were synthesized and evaluated for their antioxidant activities. The results indicated that most of the target compounds showed more potent cytoprotective effects than positive control vitamin E. In particular, dimer D5 exhibited the strongest antioxidant activity, which was significantly superior to the active compound D1 obtained in our previous study. Besides, D5 did not produce obvious cytotoxicity in normal human umbilical vein endothelial cells (HUVECs) and increased the viability of HUVECs injured by H2O2 in a concentration-dependent manner...
April 13, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28435431/dioscin-induces-demethylation-of-dapk-1-and-rassf-1alpha-genes-via-the-antioxidant-capacity-resulting-in-apoptosis-of-bladder-cancer-t24-cells
#13
Qiang Zhou, Wie Song, Wei Xiao
DNA methylation at CpG rich regions often occurs at tumor suppressor gene promoters, resulting in reduced gene expression and final carcinogenesis. Hypermethylation of tumor suppressor genes, including DAPK-1 and RASSF-1α genes, have been found in patients with bladder carcinoma (BC) in some western countries. Reactive oxygen species (ROS) was reported to play a causative role in gene hypermethylation. In this study, we detected the methylation status and expression of DAPK1 and RASSF-1α genes in tissue samples from Chinese BC patients, using methylation-specific PCR, reverse transcription PCR and western blotting...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28435317/systemic-alterations-in-plasma-proteins-from-women-with-chronic-widespread-pain-compared-to-healthy-controls-a-proteomic-study
#14
Karin Wåhlén, Patrik Olausson, Anders Carlsson, Nazdar Ghafouri, Björn Gerdle, Bijar Ghafouri
Chronic widespread pain (CWP) is a complex pain condition that is difficult to treat. The prevalence of CWP approximates ~10% of the general population, with higher prevalence in women. Lack of understanding of molecular mechanisms has been a challenge for diagnosis and treatment of chronic pain. The aim of this study was to explore the systemic protein changes in CWP compared to those in healthy controls (CON). By applying 2-dimensional gel electrophoresis, we analyzed the protein pattern of plasma samples from women with CWP (n=16) and healthy women (n=23)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28434760/omega-3-fatty-acid-supplementation-is-associated-with-oxidative-stress-and-dyslipidemia-but-does-not-contribute-to-better-lipid-and-oxidative-status-on-hemodialysis-patients
#15
Andresa Marques de Mattos, José Abrão Cardeal da Costa, Alceu Afonso Jordão Júnior, Paula Garcia Chiarello
OBJECTIVE: The aim of the study was to explore the effects of n-3 polyunsaturated fatty acids (PUFA) supplementation in physiological doses on oxidative stress (OS) and dyslipidemia in patients on hemodialysis (HD). DESIGN AND METHODS: Randomized, double-blind, controlled, experimental trial. A total of 88 HD patients ≥18 years old and on HD for at least 6 months. A total of 43 patients received 1.28 g/day of n-3 PUFA, and 45 other patients received soybean oil for 12 weeks...
April 20, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/28434730/the-effect-of-vitamin-concentrates-on-the-flavor-of-pasteurized-fluid-milk
#16
E B Yeh, A N Schiano, Y Jo, D M Barbano, M A Drake
Fluid milk consumption in the United States continues to decline. As a result, the level of dietary vitamin D provided by fluid milk in the United States diet has also declined. Undesirable flavor(s)/off flavor(s) in fluid milk can negatively affect milk consumption and consumer product acceptability. The objectives of this study were to identify aroma-active compounds in vitamin concentrates used to fortify fluid milk, and to determine the influence of vitamin A and D fortification on the flavor of milk. The aroma profiles of 14 commercial vitamin concentrates (vitamins A and D), in both oil-soluble and water-dispersible forms, were evaluated by sensory and instrumental volatile compound analyses...
April 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28433448/anemia-complicating-type-2-diabetes-prevalence-risk-factors-and-prognosis
#17
Richard Gauci, Michael Hunter, David G Bruce, Wendy A Davis, Timothy M E Davis
AIMS: To determine the prevalence, risk factors and prognosis of anemia in representative community-based patients with type 2 diabetes. METHODS: Data from the Fremantle Diabetes Study Phase II (FDS2; n=1551, mean age 65.7years, 51.9% males) and Busselton Diabetes Study (BDS; n=186, mean age 70.2years, 50.0% males) cohorts, and from 186 matched BDS participants without diabetes, were analyzed. The prevalence of anemia (hemoglobin ≤130g/L males, ≤120g/L females) was determined in each sample...
April 6, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28432750/effect-of-feeding-two-rrr-alpha-tocopherol-formulations-on-serum-cerebrospinal-fluid-and-muscle-alpha-tocopherol-concentrations-in-horses-with-subclinical-vitamin-e-deficiency
#18
J C Brown, S J Valberg, M Hogg, C J Finno
BACKGROUND: Alpha tocopherol (α-TP) supplementation is recommended for the prevention of various equine neuromuscular disorders. Formulations available include RRR-α-TP acetate powder and a more expensive but rapidly water-dispersible liquid RRR-α-TP (WD α-TP). A cost-effective means to rapidly increase serum and CSF α-TP with WD-α-TP and then sustain concentrations with RRR-α-TP acetate has not been reported. OBJECTIVES: To evaluate serum, CSF and muscle α-TP concentrations in an 8-week dosing regimen where horses were transitioned from WD RRR-α-TP to RRR-α-TP acetate...
April 22, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28431446/-vitamin-d-in-clinic-and-practice
#19
Armin Zittermann, Stefan Pilz
Vitamin D is unique among the vitamins, since its major source is skin synthesis by solar UVB exposure, whereas dietary intake plays only a minor role. In the general population, cutaneous vitamin D synthesis is clearly below the recommended amount. Dietary vitamin D does not fill this gap. Severe vitamin D deficiency results in rickets in infants and osteomalacia in adults. In the absence of endogenous vitamin D synthesis (e. g. during winter), oral supplements should ensure adequate daily vitamin D intake, where appropriate...
April 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28431245/host-microbe-co-metabolism-dictates-cancer-drug-efficacy-in-c-%C3%A2-elegans
#20
Timothy A Scott, Leonor M Quintaneiro, Povilas Norvaisas, Prudence P Lui, Matthew P Wilson, Kit-Yi Leung, Lucia Herrera-Dominguez, Sonia Sudiwala, Alberto Pessia, Peter T Clayton, Kevin Bryson, Vidya Velagapudi, Philippa B Mills, Athanasios Typas, Nicholas D E Greene, Filipe Cabreiro
Fluoropyrimidines are the first-line treatment for colorectal cancer, but their efficacy is highly variable between patients. We queried whether gut microbes, a known source of inter-individual variability, impacted drug efficacy. Combining two tractable genetic models, the bacterium E. coli and the nematode C. elegans, we performed three-way high-throughput screens that unraveled the complexity underlying host-microbe-drug interactions. We report that microbes can bolster or suppress the effects of fluoropyrimidines through metabolic drug interconversion involving bacterial vitamin B6, B9, and ribonucleotide metabolism...
April 20, 2017: Cell
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