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https://www.readbyqxmd.com/read/29924193/therapeutic-effects-of-proanthocyanidin-and-coenzyme-q10-on-nitrogen-mustard-induced-ocular-injury
#1
Abdullah Ilhan, Umit Yolcu, Emin Oztas, Uzeyir Erdem
PURPOSE: Nitrogen mustard (NM) is a devastating casualty agent in chemical warfare. There is no effective antidote to treat NM-induced ocular injury. We aimed to assess the effects of proanthocyanidin (PAC) and coenzyme Q10 (CoQ10) on NM-induced ocular injury. METHODS: Eighteen male rats were divided into the following 4 groups: NM, NM + PAC, NM + CoQ10, and control. The 3 NM groups received a single dose of NM (0.02 mg/μL) on the right eye to induce ocular injury...
June 2018: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/29882092/why-ampk-agonists-not-known-to-be-stressors-may-surprisingly-contribute-to-miscarriage-or-hinder-ivf-art
#2
REVIEW
Elizabeth E Puscheck, Alan Bolnick, Awoniyi Awonuga, Yu Yang, Mohammed Abdulhasan, Quanwen Li, Eric Secor, Erica Louden, Maik Hüttemann, Daniel A Rappolee
Here we examine recent evidence suggesting that many drugs and diet supplements (DS), experimental AMP-activated protein kinase (AMPK) agonists as well as energy-depleting stress, lead to decreases in anabolism, growth or proliferation, and potency of cultured oocytes, embryos, and stem cells in an AMPK-dependent manner. Surprising data for DS and drugs that have some activity as AMPK agonists in in vitro experiments show possible toxicity. This needs to be balanced against a preponderance of evidence in vivo that these drugs and DS are beneficial for reproduction...
June 7, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29776437/coenzyme-q10-combined-with-trimetazidine-in-the-prevention-of-contrast-induced-nephropathy-in-patients-with-coronary-heart-disease-complicated-with-renal-dysfunction-undergoing-elective-cardiac-catheterization-a-randomized-control-study-and-in-vivo-study
#3
Fei Chen, Fan Liu, Jingchao Lu, Xiuchun Yang, Bing Xiao, Yaqiong Jin, Jie Zhang
BACKGROUND: Contrast-induced nephropathy (CIN) is one of the common hospital-acquired acute renal failures. The purpose of this study was to investigate whether Coenzyme Q10 (CoQ10) and trimetazidine (TMZ) can prevent the occurrence of CIN after elective cardiac catheterization in patients with coronary artery disease complicated with renal dysfunction. METHODS: Consecutive coronary artery disease patients with renal insufficiency scheduled for coronary angiography were enrolled in randomized, paralleled, double-blind, controlled trial...
May 18, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29766349/recent-developments-in-the-role-of-coenzyme-q10-for-coronary-heart-disease-a-systematic-review
#4
REVIEW
Jessica Ayers, Jamie Cook, Rachel A Koenig, Evan M Sisson, Dave L Dixon
PURPOSE OF REVIEW: This review examines recent randomized clinical trials evaluating the role of coenzyme Q10 (CoQ10) in the management of coronary heart disease. RECENT FINDINGS: CoQ10 is one of the most commonly used dietary supplements in the USA. Due to its antioxidant and anti-inflammatory effects, CoQ10 has been studied extensively for possible use in managing coronary heart disease. One of the most common applications of CoQ10 is to mitigate statin-associated muscle symptoms (SAMS) based on the theory that SAMS are caused by statin depletion of CoQ10 in the muscle...
May 16, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29755918/coq10-a-super-vitamin-review-on-application-and-biosynthesis
#5
REVIEW
Shraddha Shukla, Kashyap Kumar Dubey
Coenzyme Q10 (CoQ) or ubiquinone is found in the biological system which is synthesized by the conjugation of benzoquinone ring with isoprenoid chain of variable length. Coenzyme Q10 supplementation energizes the body and increases body energy production in the form of ATP and helps to treat various human diseases such as cardiomyopathy, muscular dystrophy, periodontal disease, etc. Reports of these potential therapeutic advantages of CoQ10 have resulted in its high market demand, which focus the researchers to work on this molecule and develop better bioprocess methods for commercial level production...
May 2018: 3 Biotech
https://www.readbyqxmd.com/read/29731611/self-reported-adherence-and-biomarker-levels-of-coq10-and-alpha-tocopherol
#6
Mara Z Vitolins, L Douglas Case, Stephen R Rapp, Mark O Lively, Edward G Shaw, Michelle J Naughton, Jeffrey Giguere, Glenn J Lesser
Purpose: Women with breast cancer were randomized to receive coenzyme Q10 (CoQ10) plus Vitamin E or placebo in a clinical trial. The objective of this evaluation is to examine the association between participant self-reported adherence to the study supplements and changes in plasma biomarker levels. Patients and methods: Correlation coefficients quantified the association between changes in alpha-tocopherol and CoQ10 levels and the association between self-reported adherence and changes in biomarkers...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29694831/atorvastatin-in-nano-particulate-formulation-abates-muscle-and-liver-affliction-when-coalesced-with-coenzyme-q10-and-or-vitamin-e-in-hyperlipidemic-rats
#7
S M Farrag, M A Hamzawy, M F El-Yamany, M A Saad, N N Nassar
AIMS: Statins are the most widely used to lower elevated low-density lipoprotein levels and preventing cardiovascular diseases in humans. However, about 20% of patients treated with this medication suffer from statin-related myalgia. To this end, this study investigated the potential effect of nano-particulate formulation in alleviating the muscles and liver damage either alone or when co-administered with nano coenzyme Q10 and nano vitamin E. MATERIALS AND METHODS: Male Wistar rats were fed normal diet or high-fat diet for 12 weeks, following which rats were treated with either (i) atorvastatin (5 or 20 mg/kg/day, p...
June 15, 2018: Life Sciences
https://www.readbyqxmd.com/read/29688760/effects-of-an-antioxidant-enriched-multivitamin-in-cystic-fibrosis-randomized-controlled-multicenter-trial
#8
Scott D Sagel, Umer Khan, Raksha Jain, Gavin Graff, Cori L Daines, Jordan M Dunitz, Drucy Borowitz, David M Orenstein, Ibrahim Abdulhamid, Julie Noe, John P Clancy, Bonnie Slovis, Michael J Rock, Karen S McCoy, Steven Strausbaugh, Floyd R Livingston, Konstantinos A Papas, Michele L Shaffer
RATIONALE: Cystic fibrosis (CF) is characterized by dietary antioxidant deficiencies, which may contribute to an oxidant-antioxidant imbalance and oxidative stress. OBJECTIVES: Evaluate the effects of an oral antioxidant-enriched multivitamin supplement on antioxidant concentrations, markers of inflammation and oxidative stress, and clinical outcomes. METHODS: In this investigator-initiated, multicenter, randomized, double-blind, controlled trial, 73 pancreatic insufficient CF subjects 10 years of age and older with an FEV1 between 40-100% predicted were randomized to 16 weeks of an antioxidant-enriched multivitamin or control multivitamin without antioxidant enrichment...
April 24, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29684771/coenzyme-q-10-supplementation-reduces-oxidative-stress-and-decreases-antioxidant-enzyme-activity-in-children-with-autism-spectrum-disorders
#9
Elham Mousavinejad, Mohammad Ali Ghaffari, Forough Riahi, Maryam Hajmohammadi, Zeinab Tiznobeyk, Masoumeh Mousavinejad
Antioxidants and oxidative stress can participate in pathobiochemical mechanisms of autism spectrum disorders (ASDs). The aim was to identify the effects of early CoQ10 supplementation on oxidative stress in children with ASDs. Ninety children with ASDs were included in this study, based on DSM-IV criteria and using Childhood Autism Rating Scale (CARS) scores. Concentrations of CoQ10 , MDA, total antioxidant status (TAS) assay, and antioxidant enzymes (superoxide dismutase or SOD and glutathione peroxidase or GPx) activity were determined in serum before and after 100 days of supportive therapy with CoQ10 at daily doses of 30 and 60 mg...
July 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29670833/interaction-of-coenzyme-q10-with-liposomes-and-its-impact-on-suppression-of-selenite-induced-experimental-cataract
#10
Medhat Wahba Shafaa, Amany Hasan Elshazly, Amira Zaki Dakrory, Maha Reda Elsyed
Purpose: To stress the influence of Coenzyme Q10 (CoQ10) on the structural properties of liposomes as model membranes and to investigate the possible role of CoQ10 or CoQ10 doped in liposomes when topically instilled as eye drops, in preventing cataract. Methods: The molecular interaction between liposomes and Coenzyme Q10 was examined using differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). Rat pups were randomly divided into six groups comprising 15 pups. Group (1), control group...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29663894/coenzyme-q10-in-cardiovascular-and-metabolic-diseases-current-state-of-the-problem
#11
Vladlena I Zozina, Serghei Covantev, Olga A Goroshko, Liudmila M Krasnykh, Vladimir G Kukes
The burden of cardiovascular and metabolic diseases is increasing with every year. Although the management of these conditions has improved greatly over the years it is still far from perfect. With all of this in mind, there is a need for new methods of prophylaxis and treatment. Coenzyme Q10 (CoQ10) is an essential compound of the human body. There is growing evidence that CoQ10 is tightly linked to cardiometabolic disorders. Its supplementation can be useful in a variety of chronic and acute disorders. This review analyses the role of CoQ10 in hypertension, ischemic heart disease, myocardial infarction, heart failure, viral myocarditis, cardiomyopathies, cardiac toxicity, dyslipidemia, obesity, type 2 diabetes mellitus, metabolic syndrome, cardiac procedures and resuscitation...
April 15, 2018: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29663377/ubiad1-protects-against-oxygen-glucose-deprivation-reperfusion-induced-multiple-subcellular-organelles-injury-through-pi3k-akt-pathway-in-n2a-cells
#12
Yan Huang, Zhiping Hu
Cerebral ischemia/reperfusion-induced injury plays a significant role in the development of multi-subcellular organelles injury after ischemic stroke. UBIAD1 was discovered originally as a potential tumor suppressor protein. Recently, analysis of UBIAD1 has indicated it is a prenyltransferase enzyme for both non-mitochondrial CoQ10 and vitamin K2 production. Further, UBIAD1 has been localized to multiple subcellular organelles. Particularly, UBIAD1 plays an important role in the regulation of oxidative stress, apoptosis and cell proliferation, cholesterol and lipid metabolism, which was closely associated with the cerebral ischemic/reperfusion mechanism...
September 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29649786/nanoemulsions-and-topical-creams-for-the-safe-and-effective-delivery-of-lipophilic-antioxidant-coenzyme-q10
#13
M Kaci, A Belhaffef, S Meziane, G Dostert, P Menu, É Velot, S Desobry, E Arab-Tehrany
Emulsion-based delivery systems have been developed to increase the topical bioavailability of lipophilic active compounds within skin membrane. The aim was to develop nanoemulsion from natural sources (rapeseed oil) with the same sources of pure phospholipids (lecithin) rich on mono and polyunsaturated fatty acids for encapsulation of hydrophobic antioxidant (Coenzyme Q10 ) giving nanoemulsion with double functionality. Nanoemulsions were used for cream preparation using xanthan gum and carboxylmethylcellulose as texturizing agents...
July 1, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29623830/the-effects-of-coenzyme-q10-supplementation-on-lipid-profiles-among-patients-with-metabolic-diseases-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#14
Nasrin Sharifi, Reza Tabrizi, Mahmood Moosazadeh, Naghmeh Mirhosseini, Kamran B Lankarani, Maryam Akbari, Maryam Chamani, Fariba Kolahdooz, Zatollah Asemi
BACKGROUND AND OBJECTIVE: Oxidative stress and inflammation are key parameters in developing metabolic disorders. Hence, antioxidant intake might be an appropriate approach. Several studies have evaluated the effect of coenzyme Q10 (CoQ10) supplementation on lipid profile among patients with metabolic diseases, though findings are controversial. The aim of this systematic review and meta-analysis was to determine the effects of CoQ10 supplementation on lipid profile in patients with metabolic disorders...
April 5, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29606104/study-protocol-randomized-controlled-trial-reducing-symptom-burden-in-patients-with-heart-failure-with-preserved-ejection-fraction-using-ubiquinol-and-or-d-ribose
#15
Janet D Pierce, Diane E Mahoney, John B Hiebert, Amanda R Thimmesch, Francisco J Diaz, Carol Smith, Qiuhua Shen, Dinesh Pal Mudaranthakam, Richard L Clancy
BACKGROUND: Heart failure (HF), the leading cause of morbidity and mortality in the US, affects 6.6 million adults with an estimated additional 3 million people by 2030. More than 50% of HF patients have heart failure with preserved left ventricular ejection fraction (HFpEF). These patients have impaired cardiac muscle relaxation and diastolic filling, which investigators have associated with cellular energetic impairment. Patients with HFpEF experience symptoms of: (1) fatigue; (2) shortness of breath; and (3) swelling (edema) of the lower extremities...
April 2, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29589596/coq10-loaded-liposomes-combined-with-utmd-prevented-early-nephropathy-of-diabetic-rats
#16
Pian-Pian Chen, He-Lin Xu, Ting-Yue, De-Li ZhuGe, Bing-Hui Jin, Qun-Yan Zhu, Bi-Xin Shen, Li-Fen Wang, Cui-Tao Lu, Ying-Zheng Zhao, Xiao-Kun Li
Nephropathy is one of the most severe complications of diabetic patients. The therapeutic strategies for diabetic patients should not only focus on the control of blood glucose but also pay attention to the occurrence of diabetic nephropathy (DN). Coenzyme Q10 (CoQ10) has great therapeutic potential for DN. However, the clinical application of CoQ10 has been limited because of its low water-solubility and non-specific distribution. Liposomes were supposed to be an effective way for delivering CoQ10 to kidney...
February 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29587861/pretreatment-with-coenzyme-q10-improves-ovarian-response-and-embryo-quality-in-low-prognosis-young-women-with-decreased-ovarian-reserve-a-randomized-controlled-trial
#17
Yangying Xu, Victoria Nisenblat, Cuiling Lu, Rong Li, Jie Qiao, Xiumei Zhen, Shuyu Wang
BACKGROUND: Management of women with reduced ovarian reserve or poor ovarian response (POR) to stimulation is one of the major challenges in reproductive medicine. The primary causes of POR remain elusive and oxidative stress was proposed as one of the important contributors. It has been suggested that focus on the specific subpopulations within heterogeneous group of poor responders could assist in evaluating optimal management strategies for these patients. This study investigated the effect of anti-oxidant treatment with coenzyme Q10 (CoQ10) on ovarian response and embryo quality in young low-prognosis patients with POR...
March 27, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29579935/characterization-of-oat-beta-glucan-and-coenzyme-q10-loaded-beta-glucan-powders-generated-by-the-pressurized-gas-expanded-liquid-pgx-technology
#18
Nian Liu, Ricardo Couto, Bernhard Seifried, Paul Moquin, Luis Delgado, Feral Temelli
The physicochemical properties of the oat beta-glucan powder (BG) and coenzyme Q10 (CoQ10)-loaded BG powder (L-BG) produced by the pressurized gas-expanded liquid (PGX) technology were studied. Helium ion microscope, differential scanning calorimeter, X-ray diffractometer, AutoSorb iQ and rheometer were used to determine the particle morphology, thermal properties, crystallinity, surface area and viscosity, respectively. Both BG (7.7μm) and L-BG (6.1μm) were produced as micrometer-scale particles, while CoQ10 nanoparticles (92nm) were adsorbed on the porous structure of L-BG...
April 2018: Food Research International
https://www.readbyqxmd.com/read/29571016/the-role-of-nutrients-in-the-pathogenesis-and-treatment-of-migraine-headaches-review
#19
REVIEW
Elyas Nattagh-Eshtivani, Mahmood Alizadeh Sani, Monireh Dahri, Faezeh Ghalichi, Abed Ghavami, Pishva Arjang, Ali Tarighat-Esfanjani
OBJECTIVE: Migraine as a disabling neurovascular disease affects 6% of men and 18% of women worldwide. The deficiency of many nutrients including magnesium, niacin, riboflavin, cobalamin, coenzymes Q10, carnitine, α-lipoic acid and vitamin D is associated with migraine. Some researchers postulate that mitochondrial dysfunction and impaired antioxidant status can cause migraine. Also increase in homocysteine level can lead to migraine attacks; therefore, some Nutraceuticals play a vital role in migraine prevention...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29560582/a-family-segregating-lethal-neonatal-coenzyme-q-10-deficiency-caused-by-mutations-in-coq9
#20
Amanda C Smith, Yoko Ito, Afsana Ahmed, Jeremy A Schwartzentruber, Chandree L Beaulieu, Erika Aberg, Jacek Majewski, Dennis E Bulman, Karina Horsting-Wethly, Diana Vermunt-de Koning, Richard J Rodenburg, Kym M Boycott, Lynette S Penney
Primary CoQ10 deficiency is a clinically and genetically heterogeneous, autosomal recessive disorder resulting from mutations in genes involved in the synthesis of coenzyme Q10 (CoQ10 ). To date, mutations in nine proteins required for the biosynthesis of CoQ10 cause CoQ10 deficiency with varying clinical presentations. In 2009 the first patient with mutations in COQ9 was reported in an infant with a neonatal-onset, primary CoQ10 deficiency with multi-system disease. Here we describe four siblings with a previously undiagnosed lethal disorder characterized by oligohydramnios and intrauterine growth restriction, variable cardiomyopathy, anemia, and renal anomalies...
March 20, 2018: Journal of Inherited Metabolic Disease
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