keyword
MENU ▼
Read by QxMD icon Read
search

CoQ10

keyword
https://www.readbyqxmd.com/read/27911471/the-effects-of-coenzyme-q10-supplementation-on-glucose-metabolism-and-lipid-profiles-in-women-with-polycystic-ovary-syndrome-a-randomized-double-blind-placebo-controlled-trial
#1
Mansooreh Samimi, Maryam Zarezade Mehrizi, Fatemeh Foroozanfard, Hossein Akbari, Mehri Jamilian, Shahnaz Ahmadi, Zatollah Asemi
BACKGROUND: Data on the effects of coenzyme Q10 (CoQ10) supplementation on metabolic profiles among subjects with polycystic ovary syndrome (PCOS) are scarce. OBJECTIVE: This study was done to evaluate the effects of CoQ10 supplementation on glucose metabolism and lipid profiles in subjects with PCOS. DESIGN, PATIENTS AND MEASUREMENTS: This randomized double-blind, placebo-controlled trial was conducted on 60 women diagnosed with PCOS. Subjects were randomly assigned into two groups to intake either 100 mg CoQ10 supplements (N=30) or placebo (N=30) per day for 12 weeks...
December 2, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27907044/coenzyme-q10-status-as-a-determinant-of-muscular-strength-in-two-independent-cohorts
#2
Alexandra Fischer, Simone Onur, Petra Niklowitz, Thomas Menke, Matthias Laudes, Gerald Rimbach, Frank Döring
Aging is associated with sarcopenia, which is a loss of skeletal muscle mass and function. Coenzyme Q10 (CoQ10) is involved in several important functions that are related to bioenergetics and protection against oxidative damage; however, the role of CoQ10 as a determinant of muscular strength is not well documented. The aim of the present study was to evaluate the determinants of muscular strength by examining hand grip force in relation to CoQ10 status, gender, age and body mass index (BMI) in two independent cohorts (n = 334, n = 967)...
2016: PloS One
https://www.readbyqxmd.com/read/27888150/coenzyme-q10-intake-from-foods-and-semen-parameters-in-a-subfertile-population
#3
Bruno C Tiseo, Audrey J Gaskins, Russ Hauser, Jorge E Chavarro, Cigdem Tanrikut
OBJECTIVE: To assess the association between coenzyme Q10 (CoQ10) intake from food sources and semen quality. We assessed this association in a prospective cohort of men attending a fertility clinic. CoQ10 supplementation has been associated with improvements in semen parameters. However, impact of CoQ10 intake from food sources on semen quality has not been investigated. METHODS: Subfertile couples seeking fertility evaluation at the Massachusetts General Hospital Fertility Center were invited to participate in an ongoing study of environmental factors and fertility...
November 22, 2016: Urology
https://www.readbyqxmd.com/read/27837315/cloning-and-characterization-of-decaprenyl-diphosphate-synthase-from-three-different-fungi
#4
Daisuke Moriyama, Tomohiro Kaino, Kazuyoshi Yajima, Ryota Yanai, Yasuhiro Ikenaka, Junzo Hasegawa, Motohisa Washida, Hirokazu Nanba, Makoto Kawamukai
Coenzyme Q (CoQ) is composed of a benzoquinone moiety and an isoprenoid side chain of varying lengths. The length of the side chain is controlled by polyprenyl diphosphate synthase. In this study, dps1 genes encoding decaprenyl diphosphate synthase were cloned from three fungi: Bulleromyces albus, Saitoella complicata, and Rhodotorula minuta. The predicted Dps1 proteins contained seven conserved domains found in typical polyprenyl diphosphate synthases and were 528, 440, and 537 amino acids in length in B. albus, S...
November 11, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27830343/the-efficacy-and-safety-of-coenzyme-q10-in-parkinson-s-disease-a-meta-analysis-of-randomized-controlled-trials
#5
REVIEW
Zhen-Guo Zhu, Miao-Xuan Sun, Wan-Li Zhang, Wen-Wen Wang, Yi-Mei Jin, Cheng-Long Xie
The objective of this meta-analysis was to evaluate the effects of coenzyme Q10 (CoQ10) for the treatment of Parkinson's disease (PD) patients in order to arrive at qualitative and quantitative conclusions about the efficacy of CoQ10. Databases searched included PubMed, Google scholar, CNKI, Wan-Fang, and the Cochrane Library from inception to March 2016. We only included sham-controlled, randomized clinical trials of CoQ10 intervention for motor dysfunction in patients with PD. Relevant measures were extracted independently by two investigators...
November 9, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27781114/coenzyme-q10-ameliorates-trimethyltin-chloride-neurotoxicity-in-experimental-model-of-injury-in-dentate-gyrus-of-hippocampus-a-histopathological-and-behavioral-study
#6
Mohammad Hassan Sakhaie, Mansoureh Soleimani, Vahid Pirhajati, Sara Soleimani Asl, Zahra Madjd, Mehdi Mehdizadeh
BACKGROUND: Coenzyme Q10 has antioxidative and free radical scavenging effects. CoQ10 supplementation is known to have neuroprotective effects in some neurodegenerative diseases, such as Parkinson's disease and Huntington's disease. OBJECTIVES: The aim of this study was to evaluate both histopathologic and behavioral whether Coenzyme Q10 is protective against trimethyltin chloride (TMT) induced hippocampal damage. MATERIALS AND METHODS: This was an experimental study...
August 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27770619/coenzyme-q10-and-pro-inflammatory-markers-in-children-with-down-syndrome-clinical-and-biochemical-aspects
#7
Moushira E Zaki, Hala T El-Bassyouni, Angie M S Tosson, Eman Youness, Jihan Hussein
OBJECTIVE: Evidence of oxidative stress was reported in individuals with Down syndrome. There is a growing interest in the contribution of the immune system in Down syndrome. The aim of this study is to evaluate the coenzyme Q10 (CoQ10) and selected pro-inflammatory markers such as interleukin 6 (IL-6) and tumor necrosis factor α (TNFα) in children with Down syndrome. METHODS: Eighty-six children (5-8 years of age) were enrolled in this case-control study from two public institutions...
October 19, 2016: Jornal de Pediatria
https://www.readbyqxmd.com/read/27755480/high-plasma-coenzyme-q10-concentration-is-correlated-with-good-left-ventricular-performance-after-primary-angioplasty-in-patients-with-acute-myocardial-infarction
#8
Ching-Hui Huang, Chen-Ling Kuo, Ching-Shan Huang, Wan-Min Tseng, Ie Bin Lian, Chia-Chu Chang, Chin-San Liu
Exogenous administration of coenzyme Q10 (CoQ10) has been shown in experimental models to have a protective effect against ischemia-reperfusion injury. However, it is unclear whether follow-up plasma CoQ10 concentration is prognostic of left ventricular (LV) performance after primary balloon angioplasty in patients with acute ST segment elevation myocardial infarction (STEMI).We prospectively recruited 55 patients with STEMI who were treated with primary coronary balloon angioplasty. Plasma CoQ10 concentrations were measured before primary angioplasty (baseline) and 3 days, 7 days, and 1 month after STEMI using high-performance liquid chromatography...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27732894/development-of-aqueous-dispersions-of-coenzyme-q10-for-pulmonary-delivery-and-the-dynamics-of-active-vibrating-mesh-aerosolization
#9
Thiago C Carvalho, John P McCook, Niven R Narain, Jason T McConville
Coenzyme Q10 (CoQ10) is a poorly-water soluble compound that is being investigated for the treatment of carcinomas. The aim of this study was to investigate the feasibility of preparing phospholipid-stabilized dispersions of the anticancer agent for continuous pulmonary delivery using a vibrating-mesh nebulizer. We determined the physicochemical properties (drug particle size distribution in dispersion, zeta potential, surface tension, and rheology) and compared the aerosolization profiles (nebulization performance, aerodynamic drug deposition and total emitted dose) of dispersions of CoQ10 prepared with different phospholipids...
October 11, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27730347/targeting-oxidative-stress-cytokines-and-serotonin-interactions-via-indoleamine-2-3-dioxygenase-by-coenzyme-q10-role-in-suppressing-depressive-like-behavior-in-rats
#10
Sally A Abuelezz, Nevien Hendawy, Yosra Magdy
Depression is a major health problem in which oxidative stress and inflammation are inextricably connected in its pathophysiology. Coenzyme Q10 (CoQ10) is an important anti-oxidant compound with anti-inflammatory and neuro-protective properties. This study was designed to investigate the hypothesis that CoQ10 by its anti-oxidant and anti-inflammatory potentials can alleviate depressive- like behavior by restoring the balance of the tryptophan catabolites kynurenine/serotonin toward the serotonin pathway by down-regulation of hippocampal indoleamine 2,3-dioxygenase 1 (IDO-1)...
October 11, 2016: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/27693857/neuroprotective-mechanism-of-coenzyme-q10-coq10-against-ptz-induced-kindling-and-associated-cognitive-dysfunction-possible-role-of-microglia-inhibition
#11
Manveen Bhardwaj, Anil Kumar
BACKGROUND: Neuroinflammation, oxidative stress and mitochondrial dysfunction play a significant role to explain the pathophysiology of epilepsy. Neuroinflammation through microglia activation has been documented in epileptogenesis. Compounds which inhibit activation of glial cells have been suggested as one of the treatment approaches for the effective treatment of epilepsy. The present study has been designed to investigate the role of coenzyme Q10 and its interaction with minocycline (microglia inhibitor) against pentylenetetrazol (PTZ) induced kindling epilepsy...
December 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27693802/efficacy-of-coenzymeq10-in-inhibiting-monosodium-urate-crystal-induced-inflammation-in-rats
#12
B Udhaya Lavinya, Ishita Bardhan, Sabina Evan Prince
Gout is a type of arthritis, which could result from the deposition of monosodium urate crystals in joints. It can cause redness, burning pain, inflammation of joints especially in big toe. In this study, we have looked for anti-arthritic effect of coenzyme Q10 (CoQ10) on monosodium urate crystal-induced inflammation in rats and compared it with that of the non-steroidal anti-inflammatory drug, indomethacin. The evaluation was done by measuring the paw volume, antioxidant status, lipid peroxidation, lysosomal enzymes (β-glcuronidase, β-galactosidase, N-acetyl-β-d-glucosaminidase, acid phosphatase) activities and histopathological studies...
September 29, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27690645/augmenting-effect-of-vitrification-on-lipid-peroxidation-in-mouse-preantral-follicle-during-cultivation-modulation-by-coenzyme-q10
#13
Roya Hedayati Kashka, Saeed Zavareh, Taghi Lashkarbolouki
Cryopreservation-induced oxidative stress (OS) may lead to lipid peroxidation, which may be responsible for decreased cell survival rate. Coenzyme Q10 (CoQ10) as a potent antioxidant may improve cell viability by neutralizing OS. In this study, oxidative lipid injury following the vitrification of preantral follicles was investigated. The effects of CoQ10 treatment on the malondialdehyde (MDA) levels, lipid peroxidation products, and activities of enzymatic and nonenzymatic antioxidants of vitrified preantral follicles were also studied...
October 3, 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/27677262/self-nanoemulsifying-drug-delivery-system-of-coenzyme-q10-with-improved-dissolution-bioavailability-and-protective-efficiency-on-liver-fibrosis
#14
Abeer Khattab, Lobna Hassanin, Nashwah Zaki
The aim of our investigation is to develop and characterize self-nanoemulsifying drug delivery systems (SNEDDS) of CoQ10 to improve its water solubility, dissolution rate, and bioavailability, and then evaluate its biochemical and physiological effect on liver cirrhosis in rats compared with CoQ10 powder. SNEDDS are isotropic and thermodynamically stable mixture of oil, surfactant, co-surfactant, and drug that form an oil/water nanoemulsion when added to aqueous phases with soft agitation. Upon administration, self-nanoemulsifying system becomes in contact with gastrointestinal fluid and forms o/w nanoemulsion by the aid of gastrointestinal motility...
September 27, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27670440/effectiveness-of-coenzyme-q10-in-prophylactic-treatment-of-migraine-headache-an-open-label-add-on-controlled-trial
#15
Ali Shoeibi, Nahid Olfati, Mohsen Soltani Sabi, Maryam Salehi, Sara Mali, Mahsa Akbari Oryani
Despite the huge health and economic burden of migraine headache, few medications have been approved for its prophylactic treatment, most of which can potentially induce serious adverse effects. Coenzyme Q10 (CoQ10) is a supplement and has shown preliminary benefits in migraine prophylaxis. We aimed to assess this effect in an adult population. This is an open-label, parallel, add-on, match-controlled trial. Eighty patients diagnosed with migraine headache based on International Headache Society criteria were allocated to receiving only their current preventive drugs or their current preventive drugs plus 100 mg CoQ10 daily, matching for their baseline characteristics, and were assessed for frequency and severity of attacks, and ≥50 % reduction in attack frequency per month...
September 26, 2016: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/27651038/a-novel-sucla2-mutation-presenting-as-a-complex-childhood-movement-disorder
#16
Caterina Garone, Juliana Gurgel-Giannetti, Simone Sanna-Cherchi, Sindu Krishna, Ali Naini, Catarina M Quinzii, Michio Hirano
SUCLA2 defects have been associated with mitochondrial DNA (mtDNA) depletion and the triad of hypotonia, dystonia/Leigh-like syndrome, and deafness. A 9-year-old Brazilian boy of consanguineous parents presented with psychomotor delay, deafness, myopathy, ataxia, and chorea. Despite the prominent movement disorder, brain magnetic resonance imaging (MRI) was normal while (1)H-magnetic resonance spectroscopy (MRS) showed lactate peaks in the cerebral cortex and lateral ventricles. Decreased biochemical activities of mitochondrial respiratory chain enzymes containing mtDNA-encoded subunits and mtDNA depletion were observed in muscle and fibroblasts...
September 20, 2016: Journal of Child Neurology
https://www.readbyqxmd.com/read/27610419/effects-of-coenzyme-q10-on-skeletal-muscle-oxidative-metabolism-in-statin-users-assessed-using-31-p-magnetic-resonance-spectroscopy-a-randomized-controlled-study
#17
Catherine Buettner, Robert L Greenman, Long H Ngo, Jim S Wu
OBJECTIVES: Statins partially block the production of coenzyme Q10 (CoQ10), an essential component for mitochondrial function. Reduced skeletal muscle mitochondrial oxidative capacity has been proposed to be a cause of statin myalgia and can be measured using (31)phosphorus magnetic resonance spectroscopy ((31)P-MRS). The purpose of this study is to assess the effect of CoQ10 oral supplementation on mitochondrial function in statin users using (31)P-MRS. DESIGN/SETTING: In this randomized, double-blind, placebo-controlled pilot study, 21 adults aged 47-73 were randomized to statin+placebo (n=9) or statin+CoQ10 (n=12)...
2016: Journal of Nature and Science
https://www.readbyqxmd.com/read/27583276/coq10-in-progressive-supranuclear-palsy-a-randomized-placebo-controlled-double-blind-trial
#18
Diana Apetauerova, Stephanie A Scala, Robert W Hamill, David K Simon, Subash Pathak, Robin Ruthazer, David G Standaert, Talene A Yacoubian
OBJECTIVE: An investigator-initiated, multicenter, randomized, placebo-controlled, double-blind clinical trial to determine whether coenzyme Q10 (CoQ10) is safe, well tolerated, and effective in slowing functional decline in progressive supranuclear palsy (PSP). METHODS: Sixty-one participants received CoQ10 (2,400 mg/d) or placebo for up to 12 months. Progressive Supranuclear Palsy Rating Scale (PSPRS), Unified Parkinson's Disease Rating Scale, activities of daily living, Mini-Mental State Examination, the 39-item Parkinson's Disease Questionnaire, and 36-item Short Form Health Survey were monitored at baseline and months 3, 6, 9, and 12...
October 2016: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/27565065/the-effect-of-coenzyme-q10-on-venous-ischemia-reperfusion-injury
#19
Burhan Özalp, Hüseyin Elbey, Hülya Aydın, Merva S Tekkesin, Hafize Uzun
BACKGROUND: Coenzyme Q10 (CoQ10) is a lipid-soluble benzoquinone with antioxidant features that make it important in the treatment of ischemia reperfusion injury. In this study, we aimed to investigate the beneficial effect of CoQ10 in the treatment of venous ischemia/reperfusion injury. METHODS: Eighteen Sprague-Dawley male rats were randomly divided into two equal groups: the control group and an experimental group (n = 9 rats). The experimental group received CoQ10 orally, and the control group received a control diet for 8 wk...
August 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27561941/-study-of-coenzyme-q10-in-the-liver-of-preeclampsia-pregnant-rats
#20
S H Lin, J Y Yan
OBJECTIVE: To investigate the protective effect of coenzyme Q10 (CoQ10) in the liver of preeclampsiapregnant rats and the potential etiology. METHODS: Fifty pregnant SD rats were equally divided into the normal pregnant (NP) group (n=10) and the preeclampsia (PE) group (n=40) randomly. The PE rats (n=40) were equally divided into four groups randomly, distilled water (DW) group, CoQ10 group, CoQ10 combined magnesium(CM) group and magnesium (Mg) group were established by treating the preeclampsia rats on day 15 to 21 of gestation with different measures...
August 25, 2016: Zhonghua Fu Chan Ke za Zhi
keyword
keyword
26368
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"