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Implantible Cardioverter Defibrillator

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https://www.readbyqxmd.com/read/29907873/genetic-background-of-japanese-patients-with-pediatric-hypertrophic-and-restrictive-cardiomyopathy
#1
Takeharu Hayashi, Kousuke Tanimoto, Kayoko Hirayama-Yamada, Etsuko Tsuda, Mamoru Ayusawa, Shinichi Nunoda, Akira Hosaki, Akinori Kimura
Hypertrophic cardiomyopathy (HCM) and restrictive cardiomyopathy (RCM) present a high risk for sudden cardiac death in pediatric patients. The aim of this study was to identify disease-associated genetic variants in Japanese patients with pediatric HCM and RCM. We analyzed 67 cardiomyopathy-associated genes in 46 HCM and 7 RCM patients diagnosed before 16 years of age using a next-generation sequencing system. We found that 78% of HCM and 71% of RCM patients carried disease-associated genetic variants. Disease-associated genetic variants were identified in 80% of HCM patients with a family history and in 77% of HCM patients with no apparent family history (NFH)...
June 15, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29907652/cardiac-resynchronization-therapy-and-clinical-outcomes-in-continuous-flow-left-ventricular-assist-device-recipients
#2
Rakesh Gopinathannair, Henri Roukoz, Adarsh Bhan, Ashwin Ravichandran, Mustafa M Ahmed, Dmitry Familtsev, Geetha Bhat, Jennifer Cowger, Munazzah Abdullah, Chirag Sandesara, Rahul Dhawan, Emma J Birks, Jaimin R Trivedi, Mark S Slaughter
BACKGROUND: Many patients with heart failure continue cardiac resynchronization therapy (CRT) after continuous flow left ventricular assist device (CF-LVAD) implant. We report the first multicenter study to assess the impact of CRT on clinical outcomes in CF-LVAD patients. METHODS AND RESULTS: Analysis was performed on 488 patients (58±13 years, 81% male) with an implantable cardioverter defibrillator (ICD) (n=223) or CRT-D (n=265) who underwent CF-LVAD implantation at 5 centers from 2007 to 2015...
June 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29907466/sudden-death-risk-markers-for-patients-with-left-ventricular-ejection-fractions-greater-than-40
#3
REVIEW
Brian P Halliday, Amrit S Lota, Sanjay K Prasad
The major burden of sudden cardiac death (SCD) in patients with heart disease occurs in those with a left ventricular ejection fraction > 40%. Although the annual risk of SCD may be lower in these patients compared to those with lower LVEF, their lifetime cumulative risk of SCD may be greater due to a better overall prognosis. It is plausible that those with LVEF > 40% who are at highest risk of life-threatening arrhythmia will benefit from implantable cardioverter defibrillators. Features that identify patients with a LVEF > 40% at high risk of SCD are urgently needed...
June 12, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29905788/extended-use-of-the-wearable-cardioverter-defibrillator-in-patients-at-risk-for-sudden-cardiac-death
#4
Valentina Kutyifa, Katherine Vermilye, Usama A Daimee, Scott McNitt, Helmut Klein, Arthur J Moss
Aims: Data on outcomes in patients using the wearable cardioverter-defibrillator (WCD) > 90 days are limited. We aimed to analyse the clinical course of patients with WCD use ≤90 days vs. WCD use >90 days. Methods and results: We assessed arrhythmia events during WCD use, and ejection fraction (EF) improvement/implantable cardioverter-defibrillator (ICD) implantation at the end of WCD use in patients with WCD use ≤90 days vs. WCD use >90 days enrolled in the WEARIT-II registry, further assessed by disease aetiology (ischaemic vs...
June 14, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29905373/leadless-pacemaker-and-subcutaneous-implantable-cardioverter-defibrillator-therapy-the-first-use-of-a-novel-treatment-option-in-poland
#5
Krzysztof Kaczmarek, Bartosz Czarniak, Piotr Jakubowski, Jerzy K Wranicz, Paweł Ptaszyński
No abstract text is available yet for this article.
2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29899727/flecainide-induced-brugada-syndrome-in-a-patient-with-skeletal-muscle-sodium-channelopathy-a-case-report-with-critical-therapeutical-implications-and-review-of-the-literature
#6
Michele Cavalli, Barbara Fossati, Raffaele Vitale, Elisa Brigonzi, Vito A G Ricigliano, Lorenzo Saraceno, Rosanna Cardani, Carlo Pappone, Giovanni Meola
Skeletal muscle sodium channelopathies are a group of neuromuscular disorders associated with mutations in the SCN4A gene. Because principal sodium channel isoforms expressed in the skeletal muscles and the heart are distinct one from the other, this condition usually spares cardiac functioning. Nonetheless, evidence on a possible link between skeletal muscle and cardiac sodium channelopathies has emerged in recent years. To date, eight patients bearing pathogenetic mutations in the SCN4A gene and manifesting cardiac electrophysiological alterations have been reported in literature...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29898017/cohort-of-patients-referred-for-brugada-syndrome-investigation-in-an-electrophysiology-service-19-year-registry
#7
Stefan Warpechowski Neto, Tiago Luiz Luz Leiria, Laura Lessa Gaudie Ley, Antonio Lessa Gaudie Ley, Luiza Zwan Dutra, Leonardo Martins Pires, Marcelo Lapa Kruse, Gustavo Glotz de Lima
BACKGROUND: Brugada syndrome (SBr) is an arrhythmic condition characterized by ST-T segment abnormalities in the right precordial leads associated with a high risk of ventricular arrhythmias and sudden death. Local data regarding the clinical characteristics of patients with a typical electrocardiographic (ECG) pattern undergoing electrophysiological study are scarce. OBJECTIVE: To evaluate patients with an ECG pattern suggestive of SBr referred for electrophysiological evaluation in a specialized center...
June 11, 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29897106/clinical-parameters-to-optimize-patient-selection-for-subcutaneous-and-transvenous-implantable-defibrillator-therapy
#8
Anne-Floor B E Quast, Tom F Brouwer, Fleur V Y Tjong, Arthur A M Wilde, Reinoud E Knops
BACKGROUND: The subcutaneous implantable cardioverter-defibrillator (S-ICD) lacks the antitachycardia pacing (ATP) capability of tranvenous ICDs (TV-ICD). S-ICD patient selection can be challenging as some patients may benefit from ATP. We aim to identify clinical predictors of ATP benefit, in order to improve patient selection for S-ICD or TV-ICD therapy. METHODS: De novo single- and dual-chamber TV-ICD patients implanted between March 2011 and December 2015 were included...
June 13, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29896873/quantifying-the-utilization-of-medical-devices-necessary-to-detect-postmarket-safety-differences-a-case-study-of-implantable-cardioverter-defibrillators
#9
Jonathan Bates, Craig S Parzynski, Sanket S Dhruva, Andreas Coppi, Richard Kuntz, Shu-Xia Li, Danica Marinac-Dabic, Frederick A Masoudi, Richard E Shaw, Frederick Warner, Harlan M Krumholz, Joseph S Ross
PURPOSE: To estimate medical device utilization needed to detect safety differences among implantable cardioverter defibrillators (ICDs) generator models and compare these estimates to utilization in practice. METHODS: We conducted repeated sample size estimates to calculate the medical device utilization needed, systematically varying device-specific safety event rate ratios and significance levels while maintaining 80% power, testing 3 average adverse event rates (3...
June 12, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29894674/-calculator-available-prognosis-method-of-evaluation-for-predicting-survival-of-patients-with-chronic-heart-failure-and-reduced-left-ventricular-ejection-fraction
#10
L V Prokopova, M Y Sitnikova
BACKGROUND: A method for predicting one-year survival of patients with heart failure and reduced ejection fraction (HFrEF) is required to choose a management tactics and determine indications for high-tech care at the outpatient stage. AIM: To develop a method for proper prediction of survival of patients with HFrEF in outpatient clinics. MATERIALS AND METHODS: This was a prospective study of 212 patients with functional class II-IV CHF of non-valvular origin and LV EF (Simpson) ≤35 % aged 18-70, including 176 (83 %) men and 36 (17 %) women who had given an informed consent to participate in the study...
2018: Kardiologiia
https://www.readbyqxmd.com/read/29894002/analysis-of-early-failure-of-biotronik-linox-smart-implantable-cardioverter-defibrillator-leads-a-comparative-study-of-three-defibrillator-leads
#11
Diego Pérez Díez, José Manuel Rubín, David Calvo Cuervo, Daniel García Iglesias, César Morís De La Tassa
BACKGROUND AND OBJECTIVES: Early failure of Biotronik Linox and Linox Smart leads has been reported in numerous recent publications. The aim of this study was to assess the performance of this lead compared with that of 2 other contemporary leads. METHODS: We conducted an ambispective study of all consecutive first implantations of defibrillator leads carried out in our center: Endotak (Boston Scientific, model 148, 158)(n = 173), Sprint Quattro (Medtronic, model 6644, 6947)(n = 145) and Linox Smart (Biotronik, model SD 65/16)(n = 120)...
June 12, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29893508/effect-of-defibrillation-threshold-testing-on-effectiveness-of-the-subcutaneous-implantable-cardioverter-defibrillator
#12
Lakshmi Peddareddy, Faisal M Merchant, Angel R Leon, Paige Smith, Akshar Patel, Mikhael F El-Chami
BACKGROUND: Defibrillation threshold (DFT) testing is recommended with the subcutaneous ICD (SICD). OBJECTIVE: To describe first shock efficacy for appropriate SICD therapies stratified by the presence of implant DFT testing. METHODS: We reviewed all patients receiving SICDs at our institution and stratified them based on whether implant DFT testing was performed. Appropriate shocks were reviewed to see if ventricular tachycardia/ventricular fibrillation (VT/VF) terminated with a single shock...
June 12, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29885825/long-term-single-center-experience-of-defibrillator-therapy-in-children-and-adolescents
#13
Gerrit Frommeyer, Sebastian Feder, Markus Bettin, Volker Debus, Julia Köbe, Florian Reinke, Anselm Uebing, Lars Eckardt, Hans Gerd Kehl
BACKGROUND: Implantable cardioverter-defibrillator (ICD) systems are established therapy for prevention of sudden cardiac death. Long-term data on ICD systems in children and adolescents is rare. The present study displays a long-term single-center follow-up of children and adolescents with ICD systems. METHODS AND RESULTS: The present study represents a single-center experience of patients younger than 18 years who received an ICD (n = 58). Follow-up data included in-house follow-up as well as examinations of collaborating specialists...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29885706/direct-comparison-of-the-novel-automated-screening-tool-ast-versus-the-manual-screening-tool-mst-in-patients-with-already-implanted-subcutaneous-icd
#14
Nils Bögeholz, Paul Pauls, Fatih Güner, Niklas Bode, Alicia Fischer, Dirk Dechering, Gerrit Frommeyer, Julia Köbe, Kristina Wasmer, Lars Eckardt, Florian Reinke
BACKGROUND: The subcutaneous implantable cardioverter-defibrillator (S-ICD) has evolved as a valuable alternative to the transvenous ICD, especially in young patients. Unfortunately, some of these patients are ineligible for S-ICD implantation due to specific electrocardiographic features. So far, these patients were identified by mandatory pre-implantation screening using the manual screening tool (MST), which lacks objective value. Therefore, a novel automated screening tool (AST) has been introduced recently for objective screening, which has not been evaluated yet...
August 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29880624/unexpected-early-complication-of-implantable-cardioverter-defibrillator
#15
Ahmed Abdelhafez, Nancy Wassef, Kai Hogrefe, Mohsin Farooq
A 41-year-old woman was visiting Oxford, where she had a sudden cardiac arrest. Cardiopulmonary resuscitation was started by a bystander until the paramedics arrived, who found her in ventricular fibrillation, and delivered three shocks. After 28 min she had return of spontaneous circulation. Emergency coronary angiography revealed normal coronary arteries. Echocardiography followed by a cardiac MRI showed non-dilated left ventricles with no evidence of late gadolinium enhancement. She had a single-chamber implantable-cardioverter defibrillator (ICD)...
June 6, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29878937/the-clinical-profile-of-a-non-selected-population-treated-with-sacubitril-valsartan-is-different-from-paradigm-hf-trial
#16
Lourdes Vicent, Alberto Esteban-Fernández, Manuel Gómez-Bueno, Javier De-Juan, Pablo Díez-Villanueva, Ángel Manuel Iniesta, Ana Ayesta, Hugo González-Saldívar, Antonio Rojas-González, Ramón Bover-Freire, Diego Iglesias, Marcos García-Aguado, Jesús A Perea-Egido, Manuel Martínez-Sellés
Our aim is to describe the characteristics of the patients receiving sacubitril/valsartan (SV) in daily clinical practice. This is a prospective registry in 10 hospitals including all patients who started SV in everyday clinical practice.From October 2016 to March 2017, 427 patients started treatment with SV. The mean age was 68.1±12.4 years and 30.5% were women (22.0% in PARADIGM-HF, p<0.001). Comparing our cohort with patients included in PARADIGM-HF, baseline treatment was different, with a lower ratio of angiotensin converting enzyme inhibitors/angiotensin II receptor blockers (2...
May 21, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29878156/management-of-patients-with-ventricular-arrhythmias-and-prevention-of-sudden-cardiac-death-translating-guidelines-into-practice-results-of-the-european-heart-rhythm-association-survey
#17
Kristina H Haugaa, Gheorghe-Andrei Dan, Konstantinos Iliodromitis, Radoslaw Lenarczyk, Germanas Marinskis, Joaquin Osca, Daniel Scherr, Nikolaos Dagres
Prevention of sudden cardiac death (SCD) remains a partly unsolved task in cardiology. The European Society of Cardiology (ESC) guidelines on management of patients with ventricular arrhythmias and prevention of SCD published in 2015 considered the new insights of the natural history of diseases predisposing to SCD. The guidelines improved strategies for management of patients at risk of SCD and included both drug and device therapies. The intention of this survey was to evaluate the extent of the disparities between daily clinical practice and the 2015 SCD ESC guidelines among electrophysiology centres in Europe...
June 5, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29877203/leadless-pacemaker-and-subcutaneous-implantable-cardioverter-defibrillator-combination-in-a-hemodialysis-patient
#18
Yoshinari Enomoto, Hikari Hashimoto, Rina Ishii, Shunsuke Torii, Keijiro Nakamura, Mahito Noro, Kaoru Sugi, Masao Moroi, Masato Nakamura
No abstract text is available yet for this article.
June 6, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29876296/protection-field-effect-transistor-signals-recorded-on-the-leadless-electrocardiogram-channel-in-an-implantable-cardioverter-defibrillator
#19
Ameya Udyavar
No abstract text is available yet for this article.
February 2018: HeartRhythm Case Reports
https://www.readbyqxmd.com/read/29873873/change-of-sensing-vector-in-the-subcutaneous-icd-during-follow-up-and-after-device-replacement
#20
Markus Bettin, Benjamin Rath, Christian Ellermann, Patrick Leitz, Nils Bögeholz, Florian Reinke, Köbe Julia, Lars Eckardt, Gerrit Frommeyer
BACKGROUND: The subcutaneous implantable cardioverter defibrillator (S-ICD) has been established as a valuable alternative to transvenous ICD for prevention of sudden cardiac death. The system automatically chooses the optimal sensing vector. However, during follow-up and especially after device replacement we observed a change of the suggested sensing vector in automatic setup. Therefore, we analyzed frequency and reasons of vector change and its impact on inappropriate shocks (iAS)...
June 6, 2018: Journal of Cardiovascular Electrophysiology
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