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Mahfuza Mubarak, Hyokyung Jeon, Md Shahinul Islam, Cheolho Yoon, Jong-Seong Bae, Seong-Ju Hwang, Won San Choi, Ha-Jin Lee
Herein, Mg/Fe layered double hydroxide (MF-LDH) hollow nanospheres were successfully prepared by a one-step thermal method. After the thermal treatment of MF-LDH nanospheres at 400 °C, the MF-LDH was converted into the corresponding oxide, Mg/Fe layered double oxide (MF-LDO), which maintained the hollow nanosphere structure. The MF-LDO hollow nanospheres exhibited excellent adsorption efficiency for both As(V) and Cr(VI), showing 99% removal within 5 min and providing maximum removal capacities of 178...
March 6, 2018: Chemosphere
Joel K Annor-Gyamfi, Krishna Kumar Gnanasekaran, Richard A Bunce
An efficient route to substituted 1-aryl-1 H -indazoles has been developed and optimized. The method involved the preparation of arylhydrazones from acetophenone or benzaldehyde substituted by fluorine at C2 and nitro at C5, followed by deprotonation and nucleophilic aromatic substitution (SN Ar) ring closure in 45-90%. Modification of this procedure to a one-pot domino process was successful in the acetophenone series (73-96%), while the benzaldehyde series (63-73%) required a step-wise addition of reagents...
March 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Farough Nasiri, Parisa Nazari
One-pot solvent-free three-component reaction between primary amines, carbon disulfide, and 5-alkylidene rhodanines in the presence of a catalytic amount of tetra n-butylammonium bromide proceed at room temperature and produced asymmetric birhodanines in good to high yields within 5 min.
March 15, 2018: Molecular Diversity
Jochem Deen, Su Wang, Sven Van Snick, Volker Leen, Kris Janssen, Johan Hofkens, Robert K Neely
The methyltransferase enzymes can be applied to deliver a range of modifications to pre-determined sites on large DNA molecules with exceptional specificity and efficiency. To date, however, a limited number of modifications have been delivered in this way because of the complex chemical synthesis that is needed to produce a cofactor analogue carrying a specific function, such as a fluorophore. Here, we describe a method for the direct transfer of a series of functional compounds (seven fluorescent dyes, biotin and polyethylene glycol) to the DNA duplex...
March 13, 2018: Nucleic Acids Research
V Clergue-Duval, E Pot, J Azuar
BACKGROUND: General practitioners (GPs) are fully concerned with the care of patients suffering from addiction and must have the support of a specialized network. The aim of the study was to evaluate the prevalence of the addict follow-up care by GPs, their use of addictological care facilities and their needs in communicating with specialists. METHODS: Private and salaried GPs working in the 9th, 10th, 18th and 19th districts of Paris were contacted by phone, and a questionnaire was sent to those who agreed to respond...
March 12, 2018: Revue D'épidémiologie et de Santé Publique
Sajitha Biju, Sigfredo Fuentes, Dorin Gupta
Lentil (Lens culinaris, Medik.) is an important legume crop, which often experience drought stress especially at the flowering and grain filling phenological stages. The availability of efficient and robust screening tools based on relevant non-destructive quantifiable traits would facilitate research on crop improvement for drought tolerance. The objective of this study was to evaluate the drought tolerance of 37 lentil genotypes using infrared thermal imaging (IRTI), drought tolerance parameters and multivariate data analysis...
March 8, 2018: Plant Physiology and Biochemistry: PPB
Saurabh Sudha Dhiman, Namita Shrestha, Aditi David, Neha Basotra, Glenn R Johnson, Bhupinder S Chadha, Venkataramana Gadhamshetty, Rajesh K Sani
Residual solid and liquid streams from the one-pot CRUDE (Conversion of Raw and Untreated Disposal into Ethanol) process were treated with two separate biochemical routes for renewable energy transformation. The solid residual stream was subjected to thermophilic anaerobic digestion (TAD), which produced 95 ± 7 L methane kg-1 volatile solid with an overall energy efficiency of 12.9 ± 1.7%. A methanotroph, Methyloferula sp., was deployed for oxidation of mixed TAD biogas into methanol. The residual liquid stream from CRUDE process was used in a Microbial Fuel Cell (MFC) to produce electricity...
March 12, 2018: Bioresource Technology
Qi-Wei Zhang, Jaroslav Zajíček, Bradley D Smith
A [1]rotaxane with two threaded α-cyclodextrin (α-CD) wheels was synthesized in 92% yield using a one-pot process at room temperature that employed spontaneous α-CD threading onto a 12-carbon alkyl chain in water followed by an oxime condensation reaction that attached two boronic acid-containing stopper groups. Rapid pirouetting of the threaded α-CD wheels around the encapsulated dumbbell was switched "ON" or "OFF" by the presence of chemical additives that controlled boronate ester bond formation between the interlocked components...
March 15, 2018: Organic Letters
Ying Sim, Davin Tan, Rakesh Ganguly, Yongxin Li, Felipe García
Mechanochemistry has been established to be an environmentally-friendly way of conducting reactions in a solvent-free manner. The development of mechanochemical orthogonal reactions, in which multiple reagents are milled together, can be a powerful strategy to selectively yield the desired product. Such orthogonal syntheses are rare, especially those involving main group frameworks - based on bonds other than carbon - which are yet to be reported. Herein, we demonstrate the direct formation of air- and moisture-stable cyclophosph(v)azanes enabled by an orthogonal "one-step one-pot" mechanochemical reaction...
March 15, 2018: Chemical Communications: Chem Comm
Sulagna Patnaik, Gayatri Swain, K M Parida
Herein, a novel Cu-MoO3 /g-C3 N4 hybrid nanocomposite was successfully synthesized by a two-step strategy of one-pot pyrolysis followed by the impregnation method. The structure, phase, morphology and electronic environment of MoO3 , g-C3 N4 and Cu in the composite were determined by various characterization methods. The oxygen vacancies of MoO3 were ascertained by UV-DRS, Raman, and XPS analysis. The formation of the heterostructure was characterised by electrochemical measurements. The photocatalytic performance of the composite was investigated by the water reduction reaction and the reduction of an important inorganic pollutant, Cr(vi)...
March 15, 2018: Nanoscale
Assem Barakat, Abdullah M Al-Majid, Bander M Al-Qahtany, M Ali, Mohamed Teleb, Mohamed H Al-Agamy, Sehrish Naz, Zaheer Ul-Haq
BACKGROUND: Design and synthesis of pyrazole-dimedone derivatives were described by one-pot multicomponent reaction as new antimicrobial agents. These new molecular framework were synthesized in high yields with a broad substrate scope under benign conditions mediated by diethylamine (NHEt2 ). The molecular structures of the synthesized compounds were assigned based on different spectroscopic techniques (1 H-NMR,13 C-NMR, IR, MS, and CHN). RESULTS: The synthesized compounds were evaluated for their antibacterial and antifungal activities against S...
March 14, 2018: Chemistry Central Journal
S Kaiser, S V Radl, J Manhart, S Ayalur-Karunakaran, T Griesser, A Moser, C Ganser, C Teichert, W Kern, S Schlögl
The present work aims at the preparation of dry adhesives with switchable bonding properties by using the reversible nature of the [4πs+4πs] cycloaddition of anthracenes. Photo-responsive hydrogenated carboxylated nitrile butadiene rubber with photo-responsive pendant anthracene groups is prepared by one-pot synthesis. The formation of 3D networks relies on the photodimerization of the anthracene moieties upon UV exposure (λ > 300 nm). Controlled cleavage of the crosslink sites is achieved by either deep UV exposure (λ = 254 nm) or thermal dissociation at 70 °C...
March 15, 2018: Soft Matter
Kuldip D Upadhyay, Narsinh M Dodia, Rupesh C Khunt, Ravi S Chaniara, Anamik K Shah
A series of pyrano[3,2- c ]quinoline based structural analogues was synthesized using one-pot multicomponent condensation between 2,4-dihydroxy-1-methylquinoline, malononitrile, and diverse un(substituted) aromatic aldehydes. The synthesized compounds were evaluated for their anti-inflammatory and cytotoxicity activity. Initially, all the compounds were evaluated for the percent inhibition of cytokine release, and cytotoxicity activity and 50% inhibitory concentrations (IC50 ) were also determined. Based on the primary results, it was further studied for their ability to inhibit TNF-α production in the human peripheral blood mononuclear cells (hPBMC) assay...
March 8, 2018: ACS Medicinal Chemistry Letters
Jacek Mularski, Barbara Czaplińska, Wioleta Cieślik, Jakub Bebłot, Piotr Bartczak, Rafał Sitko, Jarosław Polański, Robert Musiol
Electrolytic copper is a well-known form of pure, oxygen free copper that is used for industrial applications. In this work, the catalytic potential of this relatively cheap material was studied. The addition of less than 0.015 mol equivalent of copper powder effectively catalysed the one-pot synthesis of triazoles from a diverse range of organic halides and alkynes. Quantitative conversions in aqueous solvents can be achieved within minutes. The heterogenous nature of the catalyst afforded a low level of copper contamination in the products, thus meeting the rigorous criteria of the pharmaceutical industry...
March 14, 2018: Scientific Reports
Nihat Ege Sahin, Clement Comminges, Anthony Le Valant, Julien Kiener, Julien Parmentier, Teko Napporn, Georgian Melinte, Ovidiu Ersen, Kouakou Kokoh
Copper supported mesoporous carbon nanocatalysts (Cu/FDU-15) were synthesized using an easy and convenient one-pot soft template method for low overvoltage CO2 electroreduction. The TEM imaging revealed the presence of large Cu nanoparticles (diameter 140 nm) with Cu2O nanoparticles (16 nm) as additional phase. From the electron tomography observations, it was found that the copper particles were placed inside and on the exterior surface of the porous FDU-15 support, providing an accessible surface for electrocatalytic reactions...
March 14, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Meng-Yang Chang, Yan-Shin Wu, Han-Yu Chen
A concise, one-pot synthesis of sulfonyl benzofuran-3-ones and chroman-4-ones from α-sulfonyl o-hydroxyacetophenones is described, using a combination of K2 CO3 , CuI, and dimethylsulfoxide (DMSO). This annulation protocol generates one carbon-oxygen (C-O) bond and one carbon-carbon (C-C) bond in a highly efficient manner.
March 14, 2018: Organic Letters
Weipeng Mao, Shuaijun Zhan, Bowei Zhu, Da Ma
The preparation of complex functionalized pillar[n]arenes (PA[n]s) is challenging by one-pot co-cyclization or selective deprotection method. We developed a step-growth cyclo-oligomerization method to synthesize functionalized PA[5]s. Dimer, trimer and tetramer were synthesized and characterized. With this new method, we were able to prepare three di- and tetrafunctionalized PA[5]s. By using multi-step synthetic strategy, the chance to form constitutional isomers and other by products was reduced. Therefore, complex tetrafunctionalized PA[5]s were prepared with improved yield...
March 14, 2018: Journal of Organic Chemistry
Srinivas Angapelly, P V Sri Ramya, Rohini Sodhi, Andrea Angeli, Krishnan Rangan, Narayana Nagesh, Claudiu T Supuran, Mohammed Arifuddin
A practical and transition metal-free one-pot domino synthesis of diversified (1,3,4-oxadiazol-2-yl)anilines has been developed employing isatins and hydrazides as the starting materials, in the presence of molecular iodine. The prominent feature of this domino process involves consecutive condensation, hydrolytic ring cleavage, and an intramolecular decarboxylation, in a one-pot process that leads to the oxidative formation of a C-O bond. Fluorescence properties of some of the representative molecules obtained in this way were studied...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
Christoph Stephan Schmidt, Libor Mrnka, Tomáš Frantík, Petra Lovecká, Miroslav Vosátka
Putative endophytes of Miscanthus × giganteus were isolated, and screened in the laboratory, greenhouse and field for their plant growth promoting properties in this host. Pantoea ananatis and Pseudomonas savastanoi were the predominant bacteria in leaves whereas other pseudomonads prevailed in roots. Almost all fungal endophytes belonged to the Pezizomycotina and most were isolated from roots; Fusarium oxysporum was most abundant, followed by the genera Periconia, Exophiala, Microdochium and Leptodontidium...
March 13, 2018: World Journal of Microbiology & Biotechnology
Shuai Yang, Wenkai Hua, Yanqi Wu, Tao Hu, Feng Wang, Xingxian Zhang, Fengzhi Zhang
Here we report a site-selective synthesis of functionalized dibenzo[f,h]quinolines and their derivatives, which could be used as OLED materials. The key step is the double cross coupling reaction between the 2-chloropyridinyl acids and the cyclic diaryliodonium salts, where the carboxylic acid was unprecedentedly employed as both a traceless directing group and a functional handle in a one-pot atom- and step-economical process.
March 14, 2018: Chemical Communications: Chem Comm
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