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Postural orthostatic

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https://www.readbyqxmd.com/read/28226984/analysis-of-causal-cardio-postural-interaction-under-orthostatic-stress-using-convergent-cross-mapping
#1
Ajay K Verma, Amanmeet Garg, Andrew Blaber, Reza Fazel-Rezai, Kouhyar Tavakolian, Ajay K Verma, Amanmeet Garg, Andrew Blaber, Reza Fazel-Rezai, Kouhyar Tavakolian, Ajay K Verma, Amanmeet Garg, Kouhyar Tavakolian, Reza Fazel-Rezai, Andrew Blaber
Knowledge of a cause-and-effect relationship between different physiological systems is helpful in predicting their performance under perturbations, such as orthostatic challenge. The causal coupling between representative signals of the cardiovascular and postural systems under orthostatic challenge remains unknown. Understanding the causal relationship between these two systems is critical, as their interplay is vital to maintain stable upright posture of the human body during quiet standing. In this research, convergent cross mapping (CCM) method was applied to study the causal relationship between the cardiovascular and postural systems previously shown to have coherent activity during quiet standing...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28191707/mechanisms-underlying-reflux-symptoms-and-dysphagia-in-patients-with-joint-hypermobility-syndrome-with-and-without-postural-tachycardia-syndrome
#2
A Fikree, Q Aziz, D Sifrim
BACKGROUND: The joint hypermobility syndrome (JHS) is a common non-inflammatory connective tissue disorder which frequently co-exists with postural tachycardia syndrome (PoTS), a form of orthostatic intolerance. Gastrointestinal symptoms and dysmotility have been reported in PoTS. Dysphagia and reflux are common symptoms in JHS, yet no studies have examined the physiological mechanism for these, subdivided by PoTS status. METHODS: Thirty patients (28 female, ages: 18-62) with JHS and symptoms of reflux (n=28) ± dysphagia (n=25), underwent high-resolution manometry and 24 hour pH-impedance monitoring after questionnaire-based symptom assessment...
February 12, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28185102/effects-of-intermittent-intravenous-saline-infusions-in-patients-with-medication-refractory-postural-tachycardia-syndrome
#3
Mohammed Ruzieh, Aaron Baugh, Osama Dasa, Rachel L Parker, Joseph T Perrault, Anas Renno, Beverly L Karabin, Blair Grubb
BACKGROUND: The postural tachycardia syndrome (POTS) is a heterogeneous group of disorders that results in symptoms of orthostatic intolerance. Excess blood pooling has been observed to cause low effective circulating volume in the central vasculature. Consequently, acute volume loading with IV saline has emerged as a potential strategy for clinical intervention. We evaluated the impact of acute volume loading on both the signs and symptoms of patients suffering from POTS. METHODS: Fifty-seven subjects screened from our population of POTS patients and assenting to participation were administered the two surveys by telephone...
February 9, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28168561/health-related-quality-of-life-and-suicide-risk-in-postural-tachycardia-syndrome
#4
Cathy L Pederson, Jill Blettner Brook
PURPOSE: Postural tachycardia syndrome (POTS) is a disorder featured by orthostatic intolerance. The purpose of this study was to investigate the severity of quality of life issues in POTS patients. METHODS: Online surveys for health related quality of life, sleep quality, fatigue, pain, and suicidal ideation were completed by 624 POTS patients and 139 controls. RESULTS: People with POTS have significantly more days of poor physical health (p < 0...
February 6, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28160388/cardiovascular-autonomic-dysfunction-in-ehlers-danlos-syndrome-hypermobile-type
#5
Alan Hakim, Chris O'Callaghan, Inge De Wandele, Lauren Stiles, Alan Pocinki, Peter Rowe
Autonomic dysfunction contributes to health-related impairment of quality of life in the hypermobile type of Ehlers-Danlos syndrome (hEDS). Typical signs and symptoms include tachycardia, hypotension, gastrointestinal dysmotility, and disturbed bladder function and sweating regulation. Cardiovascular autonomic dysfunction may present as Orthostatic Intolerance, Orthostatic Hypotension, Postural Orthostatic Tachycardia Syndrome, or Neurally Mediated Hypotension. The incidence, prevalence, and natural history of these conditions remain unquantified, but observations from specialist clinics suggest they are frequently seen in hEDS...
February 4, 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/28031220/pathological-ponto-cerebello-thalamo-cortical-activations-in-primary-orthostatic-tremor-during-lying-and-stance
#6
Florian Schöberl, Katharina Feil, Guoming Xiong, Peter Bartenstein, Christian la Fougére, Klaus Jahn, Thomas Brandt, Michael Strupp, Marianne Dieterich, Andreas Zwergal
Primary orthostatic tremor is a rare neurological disease characterized mainly by a high frequency tremor of the legs while standing. The aim of this study was to identify the common core structures of the oscillatory circuit in orthostatic tremor and how it is modulated by changes of body position. Ten patients with orthostatic tremor and 10 healthy age-matched control subjects underwent a standardized neurological and neuro-ophthalmological examination including electromyographic and posturographic recordings...
January 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28013227/a-prospective-study-of-the-association-between-orthostatic-hypotension-and-falls-definition-matters
#7
Claire McDonald, Mark Pearce, Simon R Kerr, Julia Newton
BACKGROUND: falls are a common cause of morbidity and mortality in older people. Orthostatic hypotension (OH) is considered an important risk factor for falls, but longitudinal studies have failed to show a clear association. This disparity may be because conventional methods of measuring blood pressure (BP) changes are too imprecise and/or the diagnostic criteria for OH are inappropriate. Over recent years, beat-to-beat BP monitoring techniques, which enabled accurate measurement of vasodepression, have become widely used and in 2011 the American Academy of Neurology produced revised diagnostic criteria for OH...
December 23, 2016: Age and Ageing
https://www.readbyqxmd.com/read/28008361/fuzzy-logic-based-risk-of-fall-estimation-using-smartwatch-data-as-a-means-to-form-an-assistive-feedback-mechanism-in-everyday-living-activities
#8
Dimitrios E Iakovakis, Fotini A Papadopoulou, Leontios J Hadjileontiadis
This Letter aims to create a fuzzy logic-based assistive prevention tool for falls, based on accessible sensory technology, such as smartwatch, resulting in monitoring of the risk factors of falls caused by orthostatic hypotension (OH); a drop in systolic blood pressure (DSBP) >20 mmHg due to postural changes. Epidemiological studies have shown that OH is a high risk factor for falls and has a strong impact in quality of life (QoL) of the elderly's, especially for some cases such as Parkinsonians. Based on smartwatch data, it is explored here how statistical features of heart rate variability (HRV) can lead to DSBP prediction and estimation of the risk of fall...
December 2016: Healthcare Technology Letters
https://www.readbyqxmd.com/read/27993582/the-association-between-orthostatic-hypotension-and-handgrip-strength-with-successful-rehabilitation-in-elderly-hip-fracture-patients
#9
L C Hartog, A M Winters, H Roijen, A M Kamper, H Inia, N Kleefstra, H J G Bilo, K J J van Hateren
OBJECTIVE: Our objectives were to investigate the relationship between orthostatic hypotension (OH) and muscle strength versus time to successful rehabilitation within elderly hip fracture patients. DESIGN: A prospective observational cohort study. Handgrip strength was measured at the day of admission and OH as soon as possible after surgery. Cox proportional hazard modelling was used to investigate the relationship between OH, or handgrip strength (kg) and time to successful rehabilitation, expressed as hazard ratios (HR)...
December 16, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27959743/autologous-adipose-stem-cell-therapy-for-autonomic-nervous-system-dysfunction-in-two-young-patients
#10
Mohammed T Numan, Ankur Kamdar, Jane Young, Ian J Butler
Postural orthostatic tachycardia syndrome and neurocardiogenic syncope are clinical manifestations of autonomic nervous system dysfunction (dysautonomia) that can lead to impaired daily functions. We report two young patients presenting with dysautonomia and autoimmune disease who both received autologous adipose stem cells (ASCs) infusions. This report is the first description of ASCs therapy for patients with combined dysautonomia and autoimmune disease. Case 1: A 21-year-old female presented at 12 years of age with escalating severe dysautonomia with weight loss and gastrointestinal symptoms...
February 1, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/27941082/parental-perceptions-of-pediatric-pain-and-pots-related-disability
#11
Elizabeth M Keating, Ryan M Antiel, Karen E Weiss, Dustin Wallace, Seth J Antiel, Philip R Fischer, Ashley N Junghans-Rutelonis, Cynthia Harbeck-Weber
Adolescents with postural orthostatic tachycardia syndrome (POTS) often have pain and functional impairment. This study evaluated how parental attributions of children's symptoms relate to child functional impairment. Adolescents with chronic pain and clinical symptoms suggestive of autonomic dysfunction (fatigue, dizziness, nausea) that attended a multidisciplinary chronic pain clinic completed measures of depression, anxiety, and functioning (n = 141). Parents of 114 of these patients completed the Parent Pain Attribution Questionnaire (PPAQ), a measure indicating the extent they believe physical and psychosocial factors account for their child's health condition...
December 8, 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27938459/recent-advances-in-the-understanding-of-the-mechanisms-underlying-postural-tachycardia-syndrome-in-children-practical-implications-for-treatment
#12
Xiaochun Zheng, Yonghong Chen, Junbao Du
Postural tachycardia syndrome is defined by a heart rate increment of 40 beats/minute (bpm) (or a heart rate that exceeds 125 bpm) within 10 minutes of change from the supine position to an upright position in the absence of obvious orthostatic hypotension. There are multiple pathophysiological mechanisms that underlie postural tachycardia syndrome, including peripheral denervation, β-receptor supersensitivity, hypovolaemia, and impaired muscle pump. Some children afflicted with postural orthostatic tachycardia syndrome and hypovolaemic dysregulation have been found to have perturbed renin-angiotensin-aldosterone profile, disturbed vascular endothelial function, and abnormal vasodilation...
December 12, 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/27903817/effects-of-orthostatic-hypotension-on-cognition-in-parkinson-disease
#13
Justin Centi, Roy Freeman, Christopher H Gibbons, Sandy Neargarder, Alexander O Canova, Alice Cronin-Golomb
OBJECTIVE: To investigate the relation between orthostatic hypotension (OH) and posture-mediated cognitive impairment in Parkinson disease (PD) using a cross-sectional and within-group design. METHODS: Individuals without dementia with idiopathic PD included 18 with OH (PDOH) and 19 without OH; 18 control participants were also included. Neuropsychological tests were conducted in supine and upright-tilted positions. Blood pressure was assessed in each posture. RESULTS: The PD groups performed similarly while supine, demonstrating executive dysfunction in sustained attention and response inhibition, and reduced semantic fluency and verbal memory (encoding and retention)...
January 3, 2017: Neurology
https://www.readbyqxmd.com/read/27894154/perfusion-controlled-mobilization-after-lower-extremity-free-flaps-pushing-the-limits-of-time-and-intensity
#14
Ulf Dornseifer, Charlotte Kleeberger, Lukas Kargl, Markus Schönberger, Daniel Rohde, Milomir Ninkovic, Arndt Schilling
Background The current standard to gradually adapt the fragile perfusion in lower extremity free flaps to an upright posture is the dangling maneuver. This type of flap training neither fits the orthostatic target load of an upright posture, nor does it assist in mobilizing the patients effectively. In this study, we quantitatively analyzed training effects of an early and full mobilization on flap perfusion. Methods A total of 15 patients with gracilis flaps for distal lower extremity reconstruction were included...
November 28, 2016: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/27884959/cardiac-responses-to-exercise-distinguish-postural-orthostatic-tachycardia-syndrome-variants
#15
Paolo T Pianosi, Darrell R Schroeder, Philip R Fischer
We previously showed that one-third of adolescents with postural orthostatic tachycardia syndrome (POTS) have hyperkinetic circulation. In a subsequent cohort, we compare participants with POTS grouped according to cardiac output (Q˙) versus oxygen uptake (V˙O2) function, whose circulatory response to exercise lay at the lower end of this distribution. We hypothesized that such grouping determines the circulatory response to incremental-protocol, upright, cycle ergometry by whatever blend of flow and resistance adjustments best maintains normal blood pressure...
November 2016: Physiological Reports
https://www.readbyqxmd.com/read/27878227/cardiovascular-coupling-during-graded-postural-challenge-comparison-between-linear-tools-and-joint-symbolic-analysis
#16
Alberto Porta, Anielle C M Takahashi, Aparecida M Catai
Background: A joint symbolic analysis (JSA) is applied to assess the strength of the cardiovascular coupling from spontaneous beat-to-beat variability of the heart period (HP) and the systolic arterial pressure (SAP) during an experimental protocol inducing a gradual baroreflex unloading evoked by postural change (i.e. graded head-up tilt). Method: The adopted JSA can quantify the degree of association between the HP and SAP variabilities as a function of the time scale of the HP and SAP patterns...
June 30, 2016: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/27867145/human-papillomavirus-vaccines-complex-regional-pain-syndrome-postural-orthostatic-tachycardia-syndrome-and-autonomic-dysfunction-a-review-of-the-regulatory-evidence-from-the-european-medicines-agency
#17
Tom Jefferson, Lars Jørgensen
Recent concerns about a possible association between exposure of young women to human papillomavirus (HPV) vaccines and two "dysautonomic syndromes" (a collection of signs and symptoms thought to be caused by autoimmunity) - complex regional pain syndrome (CRPS) and postural orthostatic tachycardia syndrome (POTS) - led the European Medicines Agency (EMA) to review existing evidence. The review was announced by the EMA on July 13, 2015, and was completed on November 4, 2015.
October 17, 2016: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/27806982/coupling-between-arterial-and-venous-cerebral-blood-flow-during-postural-change
#18
Shigehiko Ogoh, Takuro Washio, Hiroyuki Sasaki, Lonnie G Petersen, Niels H Secher, Kohei Sato
In supine humans the main drainage from the brain is through the internal jugular vein (IJV), but the vertebral veins (VV) become important during orthostatic stress because the IJV is partially collapsed. To identify the effect of this shift in venous drainage from the brain on the cerebral circulation, this study addressed both arterial and venous flow responses in the "anterior" and "posterior" parts of the brain when nine healthy subjects (5 men) were seated and flow was manipulated by hyperventilation and inhalation of 6% carbon dioxide (CO2)...
December 1, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27756060/standing-up-slowly-antagonises-initial-blood-pressure-decrease-in-older-adults-with-orthostatic-hypotension
#19
Eline S de Bruïne, Esmee M Reijnierse, Marijke C Trappenburg, Jantsje H Pasma, Oscar J de Vries, Carel G M Meskers, Andrea B Maier
BACKGROUND: Orthostatic hypotension (OH) is common in older adults and associated with increased morbidity and mortality, loss of independence and high health-care costs. Standing up slowly is a recommended non-pharmacological intervention. However, the effectiveness of this advice has not been well studied. OBJECTIVES: The aim of this study was to investigate whether standing up slowly antagonises posture-related blood pressure (BP) decrease in a clinically relevant population of geriatric outpatients...
2017: Gerontology
https://www.readbyqxmd.com/read/27753886/ish-nia-os-01-the-microrna-mir-19a-3p-binds-to-a-polymorphism-in-the-gene-for-the-noradrenaline-transporter-and-may-increase-the-risk-of-cardiovascular-and-psychiatric-disease
#20
Francine Marques, Nina Eikelis, Richard Bayles, Nora Straznicky, Dagmara Hering, Murray Esler, Geoffrey Head, Markus Schlaich, Gavin Lambert
OBJECTIVE: Noradrenaline released from sympathetic nerves is removed from the neuroeffector junction via the action of the noradrenaline transporter (NET). NET impairment is evident in several clinically important conditions including essential hypertension, major depressive disorder, panic disorder and the postural orthostatic tachycardia syndrome. Only in rare instances, however, do coding single nucleotide polymorphisms (SNPs) seem to account for a defect in NET. The aim of this study was to determine whether rs7194256 (C/T), a SNP in the 3' untranslated region (UTR) of the NET gene, is associated with diseases associated with NET dysfunction, and to elucidate the mechanism involved...
September 2016: Journal of Hypertension
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