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https://www.readbyqxmd.com/read/28506756/-estimation-of-the-population-attributable-fraction-due-to-obesity-in-hospital-admissions-for-flu-valued-according-to-body-mass-index-bmi-and-cun-bae
#1
V Dávila-Batista, D Carriedo, F Díez, A Pueyo Bastida, B Martínez Durán, V Martin
INTRODUCTION: The obesity pandemic together with the influenza pandemic could lead to a significant burden of disease. The body mass index (BMI) does not discriminate obesity appropriately. The CUN-BAE has recently been used as an estimate of body fatness for Caucasians, including BMI, gender, and age. The aim of this study is to assess the population attributable fraction of hospital admissions due to influenza, due to the body fatness measured with the BMI, and the CUN-BAE. METHODS: A multicentre study was conducted using matched case-controls...
May 11, 2017: Semergen
https://www.readbyqxmd.com/read/28484283/predicting-influenza-antigenicity-from-hemagglutintin-sequence-data-based-on-a-joint-random-forest-method
#2
Yuhua Yao, Xianhong Li, Bo Liao, Li Huang, Pingan He, Fayou Wang, Jiasheng Yang, Hailiang Sun, Yulong Zhao, Jialiang Yang
Timely identification of emerging antigenic variants is critical to influenza vaccine design. The accuracy of a sequence-based antigenic prediction method relies on the choice of amino acids substitution matrices. In this study, we first compared a comprehensive 95 substitution matrices reflecting various amino acids properties in predicting the antigenicity of influenza viruses by a random forest model. We then proposed a novel algorithm called joint random forest regression (JRFR) to jointly consider top substitution matrices...
May 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28474962/effects-of-anti-versus-pro-vaccine-narratives-on-responses-by-recipients-varying-in-numeracy-a-cross-sectional-survey-based-experiment
#3
Wändi Bruine de Bruin, Annika Wallin, Andrew M Parker, JoNell Strough, Janel Hanmer
BACKGROUND: To inform their health decisions, patients may seek narratives describing other patients' evaluations of their treatment experiences. Narratives can provide anti-treatment or pro-treatment evaluative meaning that low-numerate patients may especially struggle to derive from statistical information. Here, we examined whether anti-vaccine (v. pro-vaccine) narratives had relatively stronger effects on the perceived informativeness and judged vaccination probabilities reported among recipients with lower (v...
April 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/28466584/childhood-vaccine-status-and-correlation-with-common-nonvaccine-preventable-illnesses
#4
Michelle M Anderson, Cathy Arvidson
BACKGROUND AND PURPOSE: Current trends in parental decision making involve alteration from vaccine schedules in children, citing concerns for altered immune function. The purpose of this study was to determine if there is a difference in incidence of common childhood illnesses dependent on vaccination status. METHODS: An investigator-designed survey was administered to parents of children aged 12 months to 7 years. Participants were separated into one of three groups: fully vaccinated, partially vaccinated, and unvaccinated...
May 3, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28449918/better-knowledge-and-regular-vaccination-practices-correlate-well-with-higher-seasonal-influenza-vaccine-uptake-in-people-at-risk-promising-survey-results-from-a-university-outpatient-clinic
#5
Işıl Adadan Güvenç, Hülya Parıldar, Mustafa Kürşat Şahin, Selim Sermed Erbek
BACKGROUND: The knowledge, beliefs, opinions, and attitudes of patients and their relatives regarding seasonal influenza vaccination were evaluated. METHODS: This descriptive study was undertaken in the outpatient clinics of Baskent University Hospital. There were 566 responders who completed a self-administered questionnaire. RESULTS: The mean age of participants was 48.35 years, and 16.8% were ≥65 years. Of the responders, 21.7% were vaccinated this year, whereas 57...
April 24, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28449653/a-case-report-of-parapneumonic-pleural-effusion-caused-by-streptococcus-pneumoniae-serotype-19a-in-a-child-immunized-with-13-valent-conjugate-pneumococcal-vaccine
#6
Idrissa Diawara, Khalid Zerouali, Naima Elmdaghri, Abderrahman Abid
BACKGROUND: Simple parapneumonic effusion is a pleural effusion associated with lung infection (i.e., pneumonia). Streptococcus pneumoniae remains the most common pathogen causing parapneumonic effusions. In Morocco, the pneumococcal conjugate vaccine 13-valent (PCV13) was introduced in the national immunization program in October 2010 in 2 + 1 schedule for prevention of pneumococcal disease, and replaced by the PCV10 in July 2012 in the same schedule. We report a case of parapneumonic pleural effusions caused by S...
April 27, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28448208/explanations-for-not-receiving-the-seasonal-influenza-vaccine-an-ontario-canada-based-survey
#7
Samantha B Meyer, Rebecca Lum
Despite evidence of the importance of the seasonal influenza vaccine for both individual and population health, only a third of the Ontario population received the vaccine in 2013/2014. The objective of this study was to identify why Ontarians are not getting the seasonal influenza vaccine. Written responses to the question "Why didn't you get the seasonal flu vaccine in the last flu season?" were deductively analyzed using the Conceptual Model of Vaccine Hesitancy. Inductive coding was also conducted to identify explanations that fall outside of the present model and may be unique to the seasonal influenza vaccine...
April 27, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28434418/beliefs-and-attitudes-towards-the-influenza-vaccine-in-high-risk-individuals
#8
A J Santos, I Kislaya, A Machado, B Nunes
Societal and economic impact of influenza is mainly due to influenza infection of specific groups, who are at higher risk of health complications leading up to hospitalisation or death. In this study we applied the health belief model (HBM) to evaluate beliefs and attitudes towards influenza disease and vaccine in community-dwelling high-risk individuals (aged 65 or more or having a chronic disease). We conducted a mixed-method study using data collected through a telephone survey of a household unit sample...
April 24, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28433328/role-of-non-traditional-locations-for-seasonal-flu-vaccination-empirical-evidence-and-evaluation
#9
Namhoon Kim, Travis P Mountain
This study investigated the role of non-traditional locations in the decision to vaccinate for seasonal flu. We measured individuals' preferred location for seasonal flu vaccination by examining the National H1N1 Flu Survey (NHFS) conducted from late 2009 to early 2010. Our econometric model estimated the probabilities of possible choices by varying individual characteristics, and predicted the way in which the probabilities are expected to change given the specific covariates of interest. From this estimation, we observed that non-traditional locations significantly influenced the vaccination of certain individuals, such as those who are high-income, educated, White, employed, and living in a metropolitan statistical area (MSA), by increasing the coverage...
May 19, 2017: Vaccine
https://www.readbyqxmd.com/read/28398680/cytomegalovirus-infection-in-pregnancy
#10
REVIEW
Nicole L Davis, Caroline C King, Athena P Kourtis
Cytomegalovirus (CMV) is a DNA herpesvirus that is common worldwide. The two known main sources of primary CMV infection during pregnancy are through sexual activity and contact with young children. Primary infection occurs in approximately 1 to 4% of pregnancies, and is mostly asymptomatic in immunocompetent adults. However, primary infection may manifest as a mild mononucleosis or flu-like syndrome with persistent fever and fatigue. CMV can be transmitted from mother-to-child in utero, intrapartum, or during breastfeeding...
March 15, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28388966/vaccination-with-poly-ic-lc-and-peptide-pulsed-autologous-dendritic-cells-in-patients-with-pancreatic-cancer
#11
Shikhar Mehrotra, Carolyn D Britten, Steve Chin, Elizabeth Garrett-Mayer, Colleen A Cloud, Mingli Li, Gina Scurti, Mohamed L Salem, Michelle H Nelson, Melanie B Thomas, Chrystal M Paulos, Andres M Salazar, Michael I Nishimura, Mark P Rubinstein, Zihai Li, David J Cole
BACKGROUND: Dendritic cells (DCs) enhance the quality of anti-tumor immune response in patients with cancer. Thus, we posit that DC-based immunotherapy, in conjunction with toll-like receptor (TLR)-3 agonist poly-ICLC, is a promising approach for harnessing immunity against metastatic or locally advanced unresectable pancreatic cancer (PC). METHODS: We generated autologous DCs from the peripheral blood of HLA-A2(+) patients with PC. DCs were pulsed with three distinct A2-restricted peptides: 1) human telomerase reverse transcriptase (hTERT, TERT572Y), 2) carcinoembryonic antigen (CEA; Cap1-6D), and 3) survivin (SRV...
April 7, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28383614/management-of-two-influenza-vaccination-campaign-in-health-care-workers-of-a-university-hospital-in-the-south-italy
#12
R Squeri, R Riso, A Facciolà, C Genovese, M A R Palamara, C Ceccio, V La Fauci
BACKGROUND: In Europe, flu remains one of the major public health problems. Healthcare workers (HCWs) are a category at high-risk of contracting the infection and infecting their patients; consequently, for this category, vaccination is highly recommended. Unfortuntely, coverage levels remain insufficient with rates ranging between 4 and 40. STUDY DESIGN: The purpose of our work was to evaluate the adherence of HCWs to the influenza vaccination and to carry out a combination of educational and motivational interventions in order to increase the rate of adherence to the vaccination in this workers' category...
May 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/28376743/evaluation-of-the-immunogenicity-and-safety-of-different-doses-and-formulations-of-a-broad-spectrum-influenza-vaccine-flu-v-developed-by-seek-study-protocol-for-a-single-center-randomized-double-blind-and-placebo-controlled-clinical-phase-iib-trial
#13
Eva van Doorn, Olga Pleguezuelos, Heng Liu, Ana Fernandez, Robin Bannister, Gregory Stoloff, Fredrik Oftung, Stephen Norley, Anke Huckriede, Henderik W Frijlink, Eelko Hak
BACKGROUND: Current influenza vaccines, based on antibodies against surface antigens, are unable to provide protection against newly emerging virus strains which differ from the vaccine strains. Therefore the population has to be re-vaccinated annually. It is thus important to develop vaccines which induce protective immunity to a broad spectrum of influenza viruses. This trial is designed to evaluate the immunogenicity and safety of FLU-v, a vaccine composed of four synthetic peptides with conserved epitopes from influenza A and B strains expected to elicit both cell mediated immunity (CMI) and humoral immunity providing protection against a broad spectrum of influenza viruses...
April 4, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28375944/exploring-canadians-and-europeans-health-care-professionals-perception-of-biological-risks-patient-safety-and-professionals-safety-practices
#14
Laurence Bernard, Agnès Bernard, Alain Biron, Mélanie Lavoie-Tremblay
Patient safety has become a worldwide concern in relation to infectious diseases (Ebola/severe acute respiratory syndrome/flu). During the pandemic, different sanitary responses were documented between Europe and North America in terms of vaccination and compliance with infection prevention and control measures. The purpose of this study was to explore the health care professionals' perceptions of biological risks, patient safety, and their practices in European and Canadian health care facilities. A qualitative-descriptive design was used to explore the perceptions of biological risks and patient safety practices among health care professionals in 3 different facilities...
April 2017: Health Care Manager
https://www.readbyqxmd.com/read/28371950/-diagnosed-depression-and-utilization-of-health-care-services-and-preventive-measures-in-the-general-adult-population-in-germany
#15
Ulrike E Maske, Maren Jaedtke, Melanie Luppa, Steffi Riedel-Heller, Dieter Kleiber, Markus A Busch
Objective To examine the association of diagnosed depression with the utilization of health care services and preventive measures among men and women in the general population in Germany. Methods Cross-sectional analysis of data from a representative telephone survey (men N = 18,675, women N = 24,518, 18 years and older). Self-reported health professional-diagnosed depression (past 12 months) and the use of a range of health care and preventive services were assessed. Results Diagnosed depression was associated with increased health care service utilization in both sexes...
April 3, 2017: Psychiatrische Praxis
https://www.readbyqxmd.com/read/28366081/-the-role-of-primary-care-professionals-in-preventive-activitites-during-epidemics-focus-group-assessment-of-the-management-of-flu-pandemic-in-2009-2010
#16
Ferenc Hajnal, Csilla Busa, Renáta Papp, Sándor Balogh
INTRODUCTION: The experiences gained during the H1N1 flu pandemic in 2009/2010 could serve for a better planning and management of later outbreaks. AIM: The EU-sponsored TELL ME project aimed to provide evidence and develop models for improved risk communication during infectious disease crisis. Among its objectives was to develop original communication strategies regarding appropriate messages related to preventative behavior and advice based on uncertainties also addressing vaccine-resistant groups...
April 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28359619/predictors-of-influenza-vaccination-in-the-u-s-among-children-9-13years-of-age
#17
Teresa M Imburgia, Kristin S Hendrix, Kelly L Donahue, Lynne A Sturm, Gregory D Zimet
BACKGROUND AND OBJECTIVES: U.S. estimates of seasonal influenza (flu) vaccine uptake in 2014-2015 were 62% for 5-12year olds, dropping to 47% for 13-17year olds. The Healthy People 2020 goal for these age groups is 80%. It is important to understand factors associated with influenza vaccination, especially for those ages where rates begin to decline. The objective of this study was to identify factors associated with influenza vaccination acceptance in 9-13year old children. METHODS: An online U...
March 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28352656/trafficking-receptor-signatures-define-blood-plasmablasts-responding-to-tissue-specific-immune-challenge
#18
Yekyung Seong, Nicole H Lazarus, Lusijah Sutherland, Aida Habtezion, Tzvia Abramson, Xiao-Song He, Harry B Greenberg, Eugene C Butcher
Antibody-secreting cells are generated in regional lymphoid tissues and traffic as plasmablasts (PBs) via lymph and blood to target sites for local immunity. We used multiparameter flow cytometry to define PB trafficking programs (TPs, combinations of adhesion molecules and chemoattractant receptors) and their imprinting in patients in response to localized infection or immune insults. TPs enriched after infection or autoimmune inflammation of mucosae correlate with sites of immune response or symptoms, with different TPs imprinted during small intestinal, colon, throat, and upper respiratory immune challenge...
March 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28337690/using-active-choice-within-the-electronic-health-record-to-increase-influenza-vaccination-rates
#19
Mitesh S Patel, Kevin G Volpp, Dylan S Small, Craig Wynne, Jingsan Zhu, Lin Yang, Steven Honeywell, Susan C Day
BACKGROUND: Despite the benefits of influenza vaccination, each year more than half of adults in the United States do not receive it. OBJECTIVE: To evaluate the association between an active choice intervention in the electronic health record (EHR) and changes in influenza vaccination rates. DESIGN: Observational study. PATIENTS: Adults eligible for influenza vaccination with a clinic visit at one of three internal medicine practices at the University of Pennsylvania Health System between September 2010 and March 2013...
March 23, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28321412/recombinant-lactococcus-lactis-expressing-haemagglutinin-from-a-polish-avian-h5n1-isolate-and-its-immunological-effect-in-preliminary-animal-trials
#20
Agnieszka K Szczepankowska, Katarzyna Szatraj, Przemysław Sałański, Agnieszka Rózga, Roman K Górecki, Jacek K Bardowski
Lactic acid bacteria (LAB) are Gram-positive, nonpathogenic microorganisms that are gaining much interest as antigen producers for development of live vaccine vectors. Heterologous proteins of different origin have been successfully expressed in various LAB species, including Lactococcus lactis. Recombinant L. lactis strains have been shown to induce specific local and systemic immune responses against various antigens. Our study aimed at constructing a L. lactis strain expressing haemagglutinin of a Polish avian H5H1 influenza isolate and examining its effect on animals...
2017: BioMed Research International
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