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https://www.readbyqxmd.com/read/29349270/breaking-down-the-monolith-understanding-flu-vaccine-uptake-among-african-americans
#1
Sandra Crouse Quinn, Amelia Jamison, Ji An, Vicki S Freimuth, Gregory R Hancock, Donald Musa
Black adults are significantly less likely to be immunized for seasonal influenza when compared to Whites. This persistent disparity contributes to increased influenza-related morbidity and mortality in the African American population. Most scholarship on vaccine disparities has compared Whites and Blacks. Employing Public Health Critical Race Praxis, this study seeks to shift the focus to explore differences within the Black population. Utilizing a nationally-representative 2015 survey of US Black adults (n = 806), we explore differences by gender, age, income, and education across vaccine-related measures (e...
April 2018: SSM—Population Health
https://www.readbyqxmd.com/read/29337938/a-universal-flu-vaccine-is-vital
#2
Catharine I Paules, Anthony S Fauci
No abstract text is available yet for this article.
January 16, 2018: Scientific American
https://www.readbyqxmd.com/read/29337666/tuning-of-in-vivo-cognate-b-t-cell-interactions-by-intersectin-2-is-required-for-effective-anti-viral-b-cell-immunity
#3
Marianne Burbage, Francesca Gasparrini, Shweta Aggarwal, Mauro Gaya, Johan Arnold, Usha Nair, Michael Way, Andreas Bruckbauer, Facundo D Batista
Wiskott-Aldrich syndrome (WAS) is an immune pathology associated with mutations in WAS protein (WASp) or in WASp interacting protein (WIP). Together with the small GTPase Cdc42 and other effectors, these proteins participate in the remodelling of the actin network downstream of BCR engagement. Here we show that mice lacking the adaptor protein ITSN2, a G-nucleotide exchange factor (GEF) for Cdc42 that also interacts with WASp and WIP, exhibited increased mortality during primary infection, incomplete protection after Flu vaccination, reduced germinal centre formation and impaired antibody responses to vaccination...
January 16, 2018: ELife
https://www.readbyqxmd.com/read/29337643/models-for-predicting-the-evolution-of-influenza-to-inform-vaccine-strain-selection
#4
Joseph K Agor, Osman Y Özaltın
Influenza vaccine composition is reviewed before every flu season because influenza viruses constantly evolve through antigenic changes. To inform vaccine updates, laboratories that contribute to the World Health Organization Global Influenza Surveillance and Response System monitor the antigenic phenotypes of circulating viruses all year round. Vaccine strains are selected in anticipation of the upcoming influenza season to allow adequate time for production. A mismatch between vaccine strains and predominant strains in the flu season can significantly reduce vaccine effectiveness...
January 16, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29337134/acetylcholine-receptor-antibody-titers-and-clinical-course-after-influenza-vaccination-in-patients-with-myasthenia-gravis-a-double-blind-randomized-controlled-trial-propatient-trial
#5
Björn Tackenberg, Maximilian Schneider, Franz Blaes, Christian Eienbröker, Carmen Schade-Brittinger, Anne Wellek, Marcus Deschauer, Markus Eickmann, Hans-Dieter Klenk, Hans-Helge Müller, Norbert Sommer
BACKGROUND: It is a continuous matter of discussion whether immune activation by vaccination in general and Influenza vaccination in particular increases the risk for clinical deterioration of autoimmune diseases. This prospective study investigated the serological and clinical course of autoimmune Myasthenia gravis (MG) after a seasonal influenza vaccination. METHODS: This randomized, placebo-controlled, double-blind study enrolled MG patients with antibodies against acetylcholine-receptors (AChR-ab)...
January 10, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29336951/design-synthesis-and-evaluation-against-chikungunya-virus-of-novel-small-molecule-antiviral-agents
#6
Roberta Tardugno, Gilda Giancotti, Tine De Burghgraeve, Leen Delang, Johan Neyts, Pieter Leyssen, Andrea Brancale, Marcella Bassetto
Chikungunya virus is a re-emerging arbovirus transmitted to humans by mosquitoes, responsible for an acute flu-like illness associated with debilitating arthralgia, which can persist for several months or become chronic. In recent years, this viral infection has spread worldwide with a previously unknown virulence. To date, no specific antivirals treatments nor vaccines are available against this important pathogen. Starting from the structures of two antiviral hits previously identified in our research group with in silico techniques, this work describes the design and preparation of 31 novel structural analogues, with which different pharmacophoric features of the two hits have been explored and correlated with the inhibition of Chikungunya virus replication in cells...
January 6, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29335907/content-of-first-prenatal-visits
#7
J Dyer, G Latendresse, E Cole, J Coleman, E Rothwell
Objective The purpose of this study was to examine the content of the first prenatal visit within an academic medical center clinic and to compare the topics discussed to 2014 American College of Obstetrics and Gynecologists guidelines for the initial prenatal visit. Methods Clinical interactions were audio recorded and transcribed (n = 30). A content analysis was used to identify topics discussed during the initial prenatal visit. Topics discussed were then compared to the 2014 ACOG guidelines for adherence...
January 15, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29329685/association-of-provider-recommendation-and-offer-and-influenza-vaccination-among-adults-aged-%C3%A2-18%C3%A2-years-united-states
#8
Peng-Jun Lu, Anup Srivastav, Ashley Amaya, Jill A Dever, Jessica Roycroft, Marshica Stanley Kurtz, Alissa O'Halloran, Walter W Williams
BACKGROUND: Influenza vaccination has been recommended for all persons aged ≥6 months since 2010. METHODS: Data from the 2016 National Internet Flu Survey were analyzed to assess provider vaccination recommendations and early influenza vaccination during the 2016-17 season among adults aged ≥18 years. Predictive marginals from a multivariable logistic regression model were used to identify factors independently associated with early vaccine uptake by provider vaccination recommendation status...
January 9, 2018: Vaccine
https://www.readbyqxmd.com/read/29305418/reporting-flu-vaccine-science
#9
Rob Wipond
No abstract text is available yet for this article.
January 5, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29305384/trivalent-flu-vaccine-won-t-protect-against-influenza-b-strain-predominantly-circulating
#10
Jacqui Wise
No abstract text is available yet for this article.
January 5, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29291207/history-and-current-trends-in-influenza-virus-infections-with-special-reference-to-sri-lanka
#11
REVIEW
R A M Rafeek, M V M Divarathna, F Noordeen
The World Health Organization (WHO) estimates that approximately one billion people are infected and up to 500,000 people die from influenza each year in the world. Influenza is considered to be the greatest killer of the human populations, due to the 1918 Spanish flu, which killed millions around the world. Despite the effective treatment available against influenza, it still contributes to significant morbidity and mortality. Currently circulating influenza strains in humans include influenza A (H1N1)pdm09, influenza A (H3N2) and influenza B viruses, (B/Victoria and B/Yamagata)...
September 2017: Virusdisease
https://www.readbyqxmd.com/read/29275988/impact-of-live-attenuated-influenza-vaccination-programme-for-healthy-children-in-northern-ireland-a-comparison-of-seven-influenza-seasons-2010-11-2016-17
#12
Naomh Gallagher, Lucy Jessop, Muhammad Sartaj, Jillian Johnston
Seasonal influenza vaccination for healthy children was introduced in Northern Ireland in the 2013/14 flu season, with an initial pilot year involving two specific cohorts, followed by rollout to all children aged 4-11 years in subsequent seasons. This study aimed to examine the impact of that programme on the burden of flu in primary care over the study period 2010/11-2016/17. Two routine indicators were used to measure impact - GP in-hour consultations and out-of-hour calls for influenza and influenza-like-illness (ILI)...
December 21, 2017: Vaccine
https://www.readbyqxmd.com/read/29258804/prospective-comparative-study-of-characteristics-associated-with-influenza-a-and-b-in-adults
#13
A Chagvardieff, N Persico, C Marmillot, S Badiaga, R Charrel, A Roch
OBJECTIVES: To describe and compare the epidemiological characteristics associated with influenza type A and B as well as the characteristics associated with influenza pneumonia. The secondary objective was to evaluate the performance of influenza rapid diagnostic tests (RDT) in the emergency department. PATIENTS AND METHODS: Prospective study, including 251 adult patients admitted to the emergency department during the 2013-2014 influenza outbreaks for flu-like illness confirmed by RT-PCR...
December 16, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29230726/-it-s-still-time-to-get-the-flu-vaccine-for-this-season
#14
Bernd Salzberger, Florian Hitzenbichler, Michael Reng, Gabriele Birkenfeld
No abstract text is available yet for this article.
December 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/29223787/a-novel-peptide-based-vaccine-candidate-with-protective-efficacy-against-influenza-a-in-a-mouse-model
#15
José Herrera-Rodriguez, Tjarko Meijerhof, Hubert G Niesters, Grete Stjernholm, Arnt-Ove Hovden, Birger Sørensen, Mats Ökvist, Maja A Sommerfelt, Anke Huckriede
Current influenza vaccines mainly induce antibody responses to the variable hemagglutinin proteins of the virus strains included in the vaccine. Instead, a broadly protective influenza vaccine should aim at inducing antibody- and/or cell-mediated immunity against conserved viral proteins. Vacc-FLU is a peptide based vaccine combining conserved B and T cell epitopes. Peptide selection was done using a proprietary peptide design platform technology focusing on responses to human leukocyte antigen (HLA)-restricted epitopes...
December 7, 2017: Virology
https://www.readbyqxmd.com/read/29220514/the-influence-of-social-norms-on-flu-vaccination-among-african-american-and-white-adults
#16
Sandra Crouse Quinn, Karen M Hilyard, Amelia M Jamison, Ji An, Gregory R Hancock, Donald Musa, Vicki S Freimuth
Adult influenza vaccination rates remain suboptimal, particularly among African Americans. Social norms may influence vaccination behavior, but little research has focused on influenza vaccine and almost no research has focused on racially-specific norms. This mixed methods investigation utilizes qualitative interviews and focus groups (n = 118) and national survey results (n = 1643) to assess both descriptive and subjective norms surrounding influenza vaccination. Qualitative results suggest a perceived descriptive norm that 'about half' of the population gets vaccinated...
December 6, 2017: Health Education Research
https://www.readbyqxmd.com/read/29208594/sixty-seconds-on-flu-vaccine-for-health-staff
#17
Nigel Hawkes
No abstract text is available yet for this article.
December 5, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29175851/us-healthcare-company-fires-69-employees-for-refusing-flu-vaccination
#18
Owen Dyer
No abstract text is available yet for this article.
November 24, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29174679/molecular-epidemiology-of-influenza-b-virus-and-implications-in-immunization-strategy-southern-brazil
#19
Bruna Lapinscki, Luciane A Pereira, Meri B Nogueira, Luine R Vidal, Irina Riediger, Maria C Debur, Mayra Presibella, Sonia M Raboni
Epidemiological indicators have shown the substantial impact of influenza B (Flu B) on the development of severe acute respiratory infection (SARI) and on mortality rates. In Brazil, the trivalent vaccine, composed of only one Flu B lineage is available. We investigated Flu B infections in clinical samples collected by the epidemiological surveillance service of Paraná State, Brazil, from 2013 to 2016. The Flu B lineages Yamagata- (B/Yam) and Victoria-like (B/Vic) were identified using the qRT-PCR assay, and notification forms were reviewed...
November 22, 2017: Vaccine
https://www.readbyqxmd.com/read/29168943/flagging-up-flu-vaccination
#20
Sam Foster
Sam Foster, Chief Nurse, Oxford University Hospitals, considers the campaign for staff flu vaccination, ways to promote uptake and the thorny issue of opt-out.
November 23, 2017: British Journal of Nursing: BJN
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