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https://www.readbyqxmd.com/read/29126805/determinants-of-influenza-vaccination-among-high-risk-black-and-white-adults
#1
Sandra Crouse Quinn, Amelia M Jamison, Vicki S Freimuth, Ji An, Gregory R Hancock
BACKGROUND: Adults with chronic conditions are at much greater risk of influenza-related morbidity and mortality, yet flu vaccine uptake remains suboptimal. Research focused on the high-risk population has been limited, particularly related to racial disparities in vaccination. We explore a broad range of demographic, racial, and psychosocial factors to identify predictors of vaccination among high-risk adults, with a focus on identify differences between Black and White adults. METHODS: We conducted an online survey in March 2015, utilizing international research firm GfK's KnowledgePanel, for a nationally representative sample of Black and White adults (≥18, USA) and limited analysis adults with high-risk of influenza-related complications...
November 7, 2017: Vaccine
https://www.readbyqxmd.com/read/29112488/immunogenicity-and-safety-of-a-novel-seasonal-influenza-preservative-free-vaccine-manufactured-in-kazakhstan-results-of-a-comparative-phase-ii-clinical-trial-in-adults
#2
Gulbanu Sarsenbayeva, Yevgeniy Volgin, Markhabat Kassenov, Timur Issagulov, Nikolay Bogdanov, Abylay Sansyzbay, Marina Stukova, Zhanna Buzitskaya, Ilyas Кulmagambetov, Timur Davlyatshin, Berik Khairullin
BACKGROUND: The study was aimed at comparative evaluation of seasonal influenza vaccine RIBSP versus commercial vaccine VAXIGRIP® for immunogenicity and safety in the course of clinical trial phase II on healthy volunteers aged 18-60 years. METHODS: The trial involved 150 subjects in randomized 2:1 groups that received either RIBSP vaccine or comparator vaccine VAXIGRIP®. One dose (0.5 ml) of either vaccine contained 15 μg of hemagglutinin of each influenza virus strain recommended by WHO for the Northern hemisphere in 2016-2017 flu season...
November 7, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29104920/giving-needle-free-flu-vaccines-a-shot
#3
Sarah Webb
No abstract text is available yet for this article.
October 25, 2017: ACS Central Science
https://www.readbyqxmd.com/read/29100709/nutritional-status-of-infants-at-six-months-of-age-following-maternal-influenza-immunization-a-randomized-placebo-controlled-trial-in-rural-nepal
#4
Joanne Katz, Janet A Englund, Mark C Steinhoff, Subarna K Khatry, Laxman Shrestha, Jane Kuypers, Luke C Mullany, Helen Y Chu, Steven C LeClerq, Naoko Kozuki, James M Tielsch
BACKGROUND: Maternal influenza vaccination has increased birth weight in two randomized trials in South Asia but the impact on infant growth is unknown. METHODS: A randomized placebo-controlled trial of year round maternal influenza immunization was conducted in two annual cohorts in Sarlahi District, southern plains of Nepal, from April 2011 through April 2014. Infants born to women enrolled in the trial had weight, length, and head circumference measured at birth and 6 months of age...
October 31, 2017: Vaccine
https://www.readbyqxmd.com/read/29096710/putting-research-in-place-an-innovative-approach-to-providing-contextualized-evidence-synthesis-for-decision-makers
#5
Stephen Bornstein, Rochelle Baker, Pablo Navarro, Sarah Mackey, David Speed, Melissa Sullivan
BACKGROUND: The Contextualized Health Research Synthesis Program (CHRSP), developed in 2007 by the Newfoundland and Labrador Centre for Applied Health Research, produces contextualized knowledge syntheses for health-system decision makers. The program provides timely, relevant, and easy-to-understand scientific evidence; optimizes evidence uptake; and, most importantly, attunes research questions and evidence to the specific context in which knowledge users must apply the findings. METHODS: As an integrated knowledge translation (KT) method, CHRSP: Involves intensive partnerships with senior healthcare decision makers who propose priority research topics and participate on research teams; Considers local context both in framing the research question and in reporting the findings; Makes economical use of resources by utilizing a limited number of staff; Uses a combination of external and local experts; and Works quickly by synthesizing high-level systematic review evidence rather than primary studies...
November 2, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29070858/soloxolone-methyl-inhibits-influenza-virus-replication-and-reduces-virus-induced-lung-inflammation
#6
Andrey V Markov, Alexandra V Sen'kova, Dawid Warszycki, Oksana V Salomatina, Nariman F Salakhutdinov, Marina A Zenkova, Evgeniya B Logashenko
Highly pathogenic influenza viruses pose a serious public health threat to humans. Although vaccines are available, new antivirals are needed to efficiently control disease progression and virus transmission due to the emergence of drug-resistant viral strains. In this study, we describe the anti-viral properties of Soloxolone methyl (SM) (methyl 2-cyano-3,12-dioxo-18βH-olean-9(11),1(2)-dien-30-oate, a chemical derivative of glycyrrhetinic acid) against the flu virus. Anti-flu efficacy studies revealed that SM exhibits antiviral activity against the H1N1 influenza A virus in a dose-dependent manner causing a more than 10-fold decrease in virus titer and a reduction in the expression of NP and M2 viral proteins...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29064347/excess-mortality-in-italy-should-we-care-about-low-influenza-vaccine-uptake
#7
Francia Fausto, Pandolfi Paolo, Odone Anna, Signorelli Carlo
AIMS: The aims of this study were to explore 2015 mortality data further and to assess excess deaths' determinants. METHODS: We analysed data from a large metropolitan area in the north of Italy, the city of Bologna. We took advantage of a comprehensive local-level database and merged three different data sources to analitically explore reported 2014-2015 excess mortality and its determinants. Effect estimates were derived from multivariable Poisson regression analysis, according to vaccination status and frailty index...
October 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29059004/the-appropriateness-of-the-use-of-influenza-vaccines-recommendations-from-the-latest-seasons-in-italy
#8
Paolo Bonanni, Sara Boccalini, Patrizio Zanobini, Nawal Dakka, Chiara Lorini, Francesca Santomauro, Angela Bechini
Influenza is one of the major infectious causes of excess mortality, hospitalization, and an increase in healthcare expenditure in all countries. In an increasingly ageing population, many members are exposed to flu-related complications. Vaccination coverage rates for the elderly in most European countries, such as Italy, are not satisfactory, and have been decreasing with time due to a sense of skepticism toward vaccination. Nowadays, many types of vaccines are available on the Italian market to prevent influenza illness...
October 23, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29053369/effects-of-message-framing-on-influenza-vaccination-understanding-the-role-of-risk-disclosure-perceived-vaccine-efficacy-and-felt-ambivalence
#9
Sungsu Kim, Ivanka Pjesivac, Yan Jin
The current study examined the effects of framing in promotional health messages on intention to vaccinate against seasonal influenza virus. The findings of an experimental study (N = 86) indicated that exposure to both benefits and side effects of vaccination (gain-framed with risk disclosure message) led to lower intention to receive the flu vaccine. This relationship was mediated by both perceived vaccine efficacy and felt ambivalence in a serial order, revealing the underlying psychological mechanisms important for understanding health-related behaviors...
October 20, 2017: Health Communication
https://www.readbyqxmd.com/read/29045728/how-do-primary-care-doctors-in-england-and-wales-code-and-manage-people-with-chronic-kidney-disease-results-from-the-national-chronic-kidney-disease-audit
#10
Lois G Kim, Faye Cleary, David C Wheeler, Ben Caplin, Dorothea Nitsch, Sally A Hull
Background: In the UK, primary care records are electronic and require doctors to ascribe disease codes to direct care plans and facilitate safe prescribing. We investigated factors associated with coding of chronic kidney disease (CKD) in patients with reduced kidney function and the impact this has on patient management. Methods: We identified patients meeting biochemical criteria for CKD (two estimated glomerular filtration rates <60 mL/min/1.73 m2 taken >90 days apart) from 1039 general practitioner (GP) practices in a UK audit...
October 16, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29040317/economic-benefits-of-sharing-and-redistributing-influenza-vaccines-when-shortages-occurred
#11
Sheng-I Chen
BACKGROUND: Recurrent influenza outbreak has been a concern for government health institutions in Taiwan. Over 10% of the population is infected by influenza viruses every year, and the infection has caused losses to both health and the economy. Approximately three million free vaccine doses are ordered and administered to high-risk populations at the beginning of flu season to control the disease. The government recommends sharing and redistributing vaccine inventories when shortages occur...
2017: PloS One
https://www.readbyqxmd.com/read/29039101/methods-for-analysis-of-nanoparticle-immunosuppressive-properties-in-vitro-and-in-vivo
#12
Timothy M Potter, Barry W Neun, Marina A Dobrovolskaia
Adverse drug effects on the immune system function represent a significant concern in the pharmaceutical industry, because 10-20% of the drug withdrawal from the market is accounted to immunotoxicity. Immunosuppression is one such adverse effect. The traditional immune function test used to estimate materials' immunosuppression is a T-cell-dependent antibody response (TDAR). This method involves a 28 day in vivo study evaluating the animal's antibody titer to a known antigen (KLH) with and without challenge...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29037580/a-cross-sectional-survey-to-evaluate-knowledge-attitudes-and-practices-regarding-seasonal-influenza-and-influenza-vaccination-among-diabetics-in-pretoria-south-africa
#13
Olawale D Olatunbosun, Tonya M Esterhuizen, Charles S Wiysonge
BACKGROUND: In South Africa, influenza vaccination is recommended to all diabetics. However, vaccination coverage among diabetics remains low. Therefore, this study aimed to explore the knowledge, attitudes, and practices among people with diabetes in Pretoria regarding seasonal influenza and influenza vaccination. METHOD: A cross-sectional survey was conducted among type 1 and 2 diabetes mellitus patients who attended diabetic clinics in two major tertiary hospitals in Pretoria, South Africa from October to December 2015...
November 7, 2017: Vaccine
https://www.readbyqxmd.com/read/29030362/nhs-staff-who-refuse-flu-vaccine-this-winter-will-have-to-give-reasons
#14
Gareth Iacobucci
No abstract text is available yet for this article.
October 13, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29028558/determinants-of-trust-in-the-flu-vaccine-for-african-americans-and-whites
#15
Vicki S Freimuth, Amelia M Jamison, Ji An, Gregory R Hancock, Sandra Crouse Quinn
Trust is thought to be a major factor in vaccine decisions, but few studies have empirically tested the role of trust in adult immunization. Utilizing a 2015 national survey of African American and White adults (n = 1630), we explore multiple dimensions of trust related to influenza immunization, including generalized trust, trust in the flu vaccine, and trust in the vaccine production process. We find African Americans report lower trust than Whites across all trust measures. When considering demographic, racial, and ideological predictors, generalized trust shows statistically significant effects on both trust in the flu vaccine and trust in the vaccine process...
November 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29023541/improved-influenza-viral-vector-based-brucella-abortus-vaccine-induces-robust-b-and-t-cell-responses-and-protection-against-brucella-melitensis-infection-in-pregnant-sheep-and-goats
#16
Aigerim Mailybayeva, Bolat Yespembetov, Sholpan Ryskeldinova, Nadezhda Zinina, Abylai Sansyzbay, Gourapura J Renukaradhya, Nikolai Petrovsky, Kaissar Tabynov
We previously developed a potent candidate vaccine against bovine brucellosis caused by Brucella abortus using the influenza viral vector expressing Brucella Omp16 and L7/L12 proteins (Flu-BA). Our success in the Flu-BA vaccine trial in cattle and results of a pilot study in non-pregnant small ruminants prompted us in the current study to test its efficacy against B. melitensis infection in pregnant sheep and goats. In this study, we improved the Flu-BA vaccine formulation and immunization method to achieve maximum efficacy and safety...
2017: PloS One
https://www.readbyqxmd.com/read/29018030/general-practice-threatens-to-withhold-repeat-prescriptions-until-patients-have-flu-vaccine
#17
Gareth Iacobucci
No abstract text is available yet for this article.
October 10, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28994068/-flu-vaccination-protect-also-pregnant-women-and-your-team
#18
REVIEW
Henrike Steudel
No abstract text is available yet for this article.
October 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28986672/high-accumulation-in-tobacco-seeds-of-hemagglutinin-antigen-from-avian-h5n1-influenza
#19
Yanaysi Ceballo, Kenia Tiel, Alina López, Gleysin Cabrera, Marlene Pérez, Osmany Ramos, Yamilka Rosabal, Carlos Montero, Rima Menassa, Ann Depicker, Abel Hernández
Tobacco seeds can be used as a cost effective system for production of recombinant vaccines. Avian influenza is an important respiratory pathogen that causes a high degree of mortality and becomes a serious threat for the poultry industry. A safe vaccine against avian flu produced at low cost could help to prevent future outbreaks. We have genetically engineered tobacco plants to express extracellular domain of hemagglutinin protein from H5N1 avian influenza virus as an inexpensive alternative for production purposes...
October 6, 2017: Transgenic Research
https://www.readbyqxmd.com/read/28979265/impact-of-age-caloric-restriction-and-influenza-infection-on-mouse-gut-microbiome-an-exploratory-study-of-the-role-of-age-related-microbiome-changes-on-influenza-responses
#20
Jenna M Bartley, Xin Zhou, George A Kuchel, George M Weinstock, Laura Haynes
Immunosenescence refers to age-related declines in the capacity to respond to infections such as influenza (flu). Caloric restriction represents a known strategy to slow many aging processes, including those involving the immune system. More recently, some changes in the microbiome have been described with aging, while the gut microbiome appears to influence responses to flu vaccination and infection. With these considerations in mind, we used a well-established mouse model of flu infection to explore the impact of flu infection, aging, and caloric restriction on the gut microbiome...
2017: Frontiers in Immunology
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