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https://www.readbyqxmd.com/read/28433328/role-of-non-traditional-locations-for-seasonal-flu-vaccination-empirical-evidence-and-evaluation
#1
Namhoon Kim, Travis P Mountain
This study investigated the role of non-traditional locations in the decision to vaccinate for seasonal flu. We measured individuals' preferred location for seasonal flu vaccination by examining the National H1N1 Flu Survey (NHFS) conducted from late 2009 to early 2010. Our econometric model estimated the probabilities of possible choices by varying individual characteristics, and predicted the way in which the probabilities are expected to change given the specific covariates of interest. From this estimation, we observed that non-traditional locations significantly influenced the vaccination of certain individuals, such as those who are high-income, educated, White, employed, and living in a metropolitan statistical area (MSA), by increasing the coverage...
April 19, 2017: Vaccine
https://www.readbyqxmd.com/read/28398680/cytomegalovirus-infection-in-pregnancy
#2
REVIEW
Nicole L Davis, Caroline C King, Athena P Kourtis
Cytomegalovirus (CMV) is a DNA herpesvirus that is common worldwide. The two known main sources of primary CMV infection during pregnancy are through sexual activity and contact with young children. Primary infection occurs in approximately 1 to 4% of pregnancies, and is mostly asymptomatic in immunocompetent adults. However, primary infection may manifest as a mild mononucleosis or flu-like syndrome with persistent fever and fatigue. CMV can be transmitted from mother-to-child in utero, intrapartum, or during breastfeeding...
March 15, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28388966/vaccination-with-poly-ic-lc-and-peptide-pulsed-autologous-dendritic-cells-in-patients-with-pancreatic-cancer
#3
Shikhar Mehrotra, Carolyn D Britten, Steve Chin, Elizabeth Garrett-Mayer, Colleen A Cloud, Mingli Li, Gina Scurti, Mohamed L Salem, Michelle H Nelson, Melanie B Thomas, Chrystal M Paulos, Andres M Salazar, Michael I Nishimura, Mark P Rubinstein, Zihai Li, David J Cole
BACKGROUND: Dendritic cells (DCs) enhance the quality of anti-tumor immune response in patients with cancer. Thus, we posit that DC-based immunotherapy, in conjunction with toll-like receptor (TLR)-3 agonist poly-ICLC, is a promising approach for harnessing immunity against metastatic or locally advanced unresectable pancreatic cancer (PC). METHODS: We generated autologous DCs from the peripheral blood of HLA-A2(+) patients with PC. DCs were pulsed with three distinct A2-restricted peptides: 1) human telomerase reverse transcriptase (hTERT, TERT572Y), 2) carcinoembryonic antigen (CEA; Cap1-6D), and 3) survivin (SRV...
April 7, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28383614/management-of-two-influenza-vaccination-campaign-in-health-care-workers-of-a-university-hospital-in-the-south-italy
#4
R Squeri, R Riso, A Facciolà, C Genovese, M A R Palamara, C Ceccio, V La Fauci
BACKGROUND: In Europe, flu remains one of the major public health problems. Healthcare workers (HCWs) are a category at high-risk of contracting the infection and infecting their patients; consequently, for this category, vaccination is highly recommended. Unfortuntely, coverage levels remain insufficient with rates ranging between 4 and 40. STUDY DESIGN: The purpose of our work was to evaluate the adherence of HCWs to the influenza vaccination and to carry out a combination of educational and motivational interventions in order to increase the rate of adherence to the vaccination in this workers' category...
May 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/28376743/evaluation-of-the-immunogenicity-and-safety-of-different-doses-and-formulations-of-a-broad-spectrum-influenza-vaccine-flu-v-developed-by-seek-study-protocol-for-a-single-center-randomized-double-blind-and-placebo-controlled-clinical-phase-iib-trial
#5
Eva van Doorn, Olga Pleguezuelos, Heng Liu, Ana Fernandez, Robin Bannister, Gregory Stoloff, Fredrik Oftung, Stephen Norley, Anke Huckriede, Henderik W Frijlink, Eelko Hak
BACKGROUND: Current influenza vaccines, based on antibodies against surface antigens, are unable to provide protection against newly emerging virus strains which differ from the vaccine strains. Therefore the population has to be re-vaccinated annually. It is thus important to develop vaccines which induce protective immunity to a broad spectrum of influenza viruses. This trial is designed to evaluate the immunogenicity and safety of FLU-v, a vaccine composed of four synthetic peptides with conserved epitopes from influenza A and B strains expected to elicit both cell mediated immunity (CMI) and humoral immunity providing protection against a broad spectrum of influenza viruses...
April 4, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28375944/exploring-canadians-and-europeans-health-care-professionals-perception-of-biological-risks-patient-safety-and-professional-s-safety-practices
#6
Laurence Bernard, Agnès Bernard, Alain Biron, Mélanie Lavoie-Tremblay
Patient safety has become a worldwide concern in relation to infectious diseases (Ebola/severe acute respiratory syndrome/flu). During the pandemic, different sanitary responses were documented between Europe and North America in terms of vaccination and compliance with infection prevention and control measures. The purpose of this study was to explore the health care professional's perceptions of biological risks, patient safety, and their practices in European and Canadian health care facilities. A qualitative-descriptive design was used to explore the perceptions of biological risks and patient safety practices among health care professionals in 3 different facilities...
April 3, 2017: Health Care Manager
https://www.readbyqxmd.com/read/28371950/-diagnosed-depression-and-utilization-of-health-care-services-and-preventive-measures-in-the-general-adult-population-in-germany
#7
Ulrike E Maske, Maren Jaedtke, Melanie Luppa, Steffi Riedel-Heller, Dieter Kleiber, Markus A Busch
Objective To examine the association of diagnosed depression with the utilization of health care services and preventive measures among men and women in the general population in Germany. Methods Cross-sectional analysis of data from a representative telephone survey (men N = 18,675, women N = 24,518, 18 years and older). Self-reported health professional-diagnosed depression (past 12 months) and the use of a range of health care and preventive services were assessed. Results Diagnosed depression was associated with increased health care service utilization in both sexes...
April 3, 2017: Psychiatrische Praxis
https://www.readbyqxmd.com/read/28366081/-the-role-of-primary-care-professionals-in-preventive-activitites-during-epidemics-focus-group-assessment-of-the-management-of-flu-pandemic-in-2009-2010
#8
Ferenc Hajnal, Csilla Busa, Renáta Papp, Sándor Balogh
INTRODUCTION: The experiences gained during the H1N1 flu pandemic in 2009/2010 could serve for a better planning and management of later outbreaks. AIM: The EU-sponsored TELL ME project aimed to provide evidence and develop models for improved risk communication during infectious disease crisis. Among its objectives was to develop original communication strategies regarding appropriate messages related to preventative behavior and advice based on uncertainties also addressing vaccine-resistant groups...
April 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28359619/predictors-of-influenza-vaccination-in-the-u-s-among-children-9-13years-of-age
#9
Teresa M Imburgia, Kristin S Hendrix, Kelly L Donahue, Lynne A Sturm, Gregory D Zimet
BACKGROUND AND OBJECTIVES: U.S. estimates of seasonal influenza (flu) vaccine uptake in 2014-2015 were 62% for 5-12year olds, dropping to 47% for 13-17year olds. The Healthy People 2020 goal for these age groups is 80%. It is important to understand factors associated with influenza vaccination, especially for those ages where rates begin to decline. The objective of this study was to identify factors associated with influenza vaccination acceptance in 9-13year old children. METHODS: An online U...
March 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28352656/trafficking-receptor-signatures-define-blood-plasmablasts-responding-to-tissue-specific-immune-challenge
#10
Yekyung Seong, Nicole H Lazarus, Lusijah Sutherland, Aida Habtezion, Tzvia Abramson, Xiao-Song He, Harry B Greenberg, Eugene C Butcher
Antibody-secreting cells are generated in regional lymphoid tissues and traffic as plasmablasts (PBs) via lymph and blood to target sites for local immunity. We used multiparameter flow cytometry to define PB trafficking programs (TPs, combinations of adhesion molecules and chemoattractant receptors) and their imprinting in patients in response to localized infection or immune insults. TPs enriched after infection or autoimmune inflammation of mucosae correlate with sites of immune response or symptoms, with different TPs imprinted during small intestinal, colon, throat, and upper respiratory immune challenge...
March 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28337690/using-active-choice-within-the-electronic-health-record-to-increase-influenza-vaccination-rates
#11
Mitesh S Patel, Kevin G Volpp, Dylan S Small, Craig Wynne, Jingsan Zhu, Lin Yang, Steven Honeywell, Susan C Day
BACKGROUND: Despite the benefits of influenza vaccination, each year more than half of adults in the United States do not receive it. OBJECTIVE: To evaluate the association between an active choice intervention in the electronic health record (EHR) and changes in influenza vaccination rates. DESIGN: Observational study. PATIENTS: Adults eligible for influenza vaccination with a clinic visit at one of three internal medicine practices at the University of Pennsylvania Health System between September 2010 and March 2013...
March 23, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28321412/recombinant-lactococcus-lactis-expressing-haemagglutinin-from-a-polish-avian-h5n1-isolate-and-its-immunological-effect-in-preliminary-animal-trials
#12
Agnieszka K Szczepankowska, Katarzyna Szatraj, Przemysław Sałański, Agnieszka Rózga, Roman K Górecki, Jacek K Bardowski
Lactic acid bacteria (LAB) are Gram-positive, nonpathogenic microorganisms that are gaining much interest as antigen producers for development of live vaccine vectors. Heterologous proteins of different origin have been successfully expressed in various LAB species, including Lactococcus lactis. Recombinant L. lactis strains have been shown to induce specific local and systemic immune responses against various antigens. Our study aimed at constructing a L. lactis strain expressing haemagglutinin of a Polish avian H5H1 influenza isolate and examining its effect on animals...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28314047/the-role-of-risk-perception-in-flu-vaccine-behavior-among-african-american-and-white-adults-in-the-united-states
#13
Vicki S Freimuth, Amelia Jamison, Gregory Hancock, Donald Musa, Karen Hilyard, Sandra Crouse Quinn
Seasonal flu vaccination rates are low for U.S. adults, with significant disparities between African and white Americans. Risk perception is a significant predictor of vaccine behavior but the research on this construct has been flawed. This study addressed critical research questions to understand the differences between African and white Americans in the role of risk perception in flu vaccine behavior: (1) What is the dimensionality of risk perception and does it differ between the two races?  (2) Were risk perceptions of white and African-American populations different and how were sociodemographic characteristics related to risk for each group? (3) What is the relation between risk perception and flu vaccine behaviors for African Americans and whites? The sample, drawn from GfK's Knowledge Panel, consisted of 838 whites and 819 African Americans...
March 17, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28303960/the-immune-correlates-of-protection-for-an-avian-influenza-h5n1-vaccine-in-the-ferret-model-using-oil-in-water-adjuvants
#14
Sook-San Wong, Susu Duan, Jennifer DeBeauchamp, Mark Zanin, Lisa Kercher, Stephanie Sonnberg, Thomas Fabrizio, Trushar Jeevan, Jeri-Carol Crumpton, Christine Oshansky, Yilun Sun, Li Tang, Paul Thomas, Richard Webby
Because of the pathogenicity and low incidence of avian influenza virus infections in humans, the immune correlates of protection for avian influenza vaccines cannot be determined from clinical studies. Here, we used the ferret model to address this for an avian influenza H5N1 vaccine. Using oil-in-water adjuvants, we generated groups of ferrets with undetectable (geometric mean titer [GMT] < 10), low (GMT = 28.3), or high (GMT > 761.1) hemagglutination-inhibition (HAI) titers to the A/Viet Nam/1203/2004 (H5N1) virus...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28301280/panblok-h1-advax-h1n1-2009pdm-vaccine-insights-into-rapid-development-of-an-delta-inulin-adjuvanted-recombinant-pandemic-influenza-vaccine
#15
Yoshikazu Honda-Okubo, Harinda Rajapaksha, Dimitar Sajkov, David Gordon, Manon M J Cox, Nikolai Petrovsky
Timely vaccine supply is critical during influenza pandemics but is impeded by current virus-based manufacturing methods. The 2009 H1N1/2009pdm 'swine flu' pandemic reinforced the need for innovation in pandemic vaccine design. We report on insights gained during rapid development of a pandemic vaccine based on recombinant haemagglutinin (rHA) formulated with Advax™ delta inulin adjuvant (Panblok-H1/Advax). Panblok-H1/Advax was designed and manufactured within 1 month of the pandemic declaration by WHO and successfully entered human clinical testing in under 3 months from first isolation and sequencing of the novel pandemic virus, requiring several major challenges to be overcome...
February 14, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28288597/school-based-vaccination-programmes-a-systematic-review-of-the-evidence-on-organisation-and-delivery-in-high-income-countries
#16
Sarah Perman, Simon Turner, Angus I G Ramsay, Abigail Baim-Lance, Martin Utley, Naomi J Fulop
BACKGROUND: Many countries have recently expanded their childhood immunisation programmes. Schools are an increasingly attractive setting for delivery of these new immunisations because of their ability to reach large numbers of children in a short period of time. However, there are organisational challenges to delivery of large-scale vaccination programmes in schools. Understanding the facilitators and barriers is important for improving the delivery of future school-based vaccination programmes...
March 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28288596/needles-jabs-and-jags-a-qualitative-exploration-of-barriers-and-facilitators-to-child-and-adult-immunisation-uptake-among-gypsies-travellers-and-roma
#17
Cath Jackson, Helen Bedford, Francine M Cheater, Louise Condon, Carol Emslie, Lana Ireland, Philippa Kemsley, Susan Kerr, Helen J Lewis, Julie Mytton, Karen Overend, Sarah Redsell, Zoe Richardson, Christine Shepherd, Lesley Smith, Lisa Dyson
BACKGROUND: Gypsies, Travellers and Roma (referred to as Travellers) are less likely to access health services including immunisation. To improve immunisation rates, it is necessary to understand what helps and hinders individuals in these communities in taking up immunisations. This study had two aims. 1. Investigate the views of Travellers in the UK on the barriers and facilitators to acceptability and uptake of immunisations and explore their ideas for improving immunisation uptake; 2...
March 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28285984/the-advance-code-of-conduct-for-collaborative-vaccine-studies
#18
REVIEW
Xavier Kurz, Vincent Bauchau, Patrick Mahy, Steffen Glismann, Lieke Maria van der Aa, François Simondon
Lessons learnt from the 2009 (H1N1) flu pandemic highlighted factors limiting the capacity to collect European data on vaccine exposure, safety and effectiveness, including lack of rapid access to available data sources or expertise, difficulties to establish efficient interactions between multiple parties, lack of confidence between private and public sectors, concerns about possible or actual conflicts of interest (or perceptions thereof) and inadequate funding mechanisms. The Innovative Medicines Initiative's Accelerated Development of VAccine benefit-risk Collaboration in Europe (ADVANCE) consortium was established to create an efficient and sustainable infrastructure for rapid and integrated monitoring of post-approval benefit-risk of vaccines, including a code of conduct and governance principles for collaborative studies...
March 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28284680/psychological-factors-associated-with-uptake-of-the-childhood-influenza-vaccine-and-perception-of-post-vaccination-side-effects-a-cross-sectional-survey-in-england
#19
Louise E Smith, Rebecca K Webster, John Weinman, Richard Amlôt, Jenny Yiend, G James Rubin
OBJECTIVES: To identify predictors of: uptake of the childhood influenza vaccine in the 2015-2016 influenza season, parental perceptions of side-effects from the influenza vaccine and intention to vaccinate one's child for influenza in the 2016-2017 influenza season. DESIGN: Cross-sectional online survey. SETTING: Data were collected in England shortly after the end of the 2015-2016 immunization campaign. PARTICIPANTS: 1001 parents or guardians of children aged between two and seven...
February 24, 2017: Vaccine
https://www.readbyqxmd.com/read/28281365/seasons-and-als-time-of-death
#20
Susana Pinto, Mamede De Carvalho
INTRODUCTION: Respiratory complications are the main cause of death in amyotrophic lateral sclerosis (ALS). Season-associated-death risk was not addressed before. OBJECTIVE: To assess month/season-associated death risk in ALS. METHODS: We included all patients followed in our unit who died before 1 January 2016, excluding those with uncertain information. A χ(2) test assessed differences between months/seasons. A two-step cluster analysis explored the significant survival independent factors...
March 10, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
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