keyword
https://read.qxmd.com/read/38303067/exposure-to-residential-traffic-and-trajectories-of-unhealthy-ageing-results-from-a-nationally-representative-cohort-of-older-adults
#21
JOURNAL ARTICLE
Sergio Gómez Del Río, Elena Plans-Beriso, Rebeca Ramis, Rosario Ortolá, Roberto Pastor, Mercedes Sotos-Prieto, Adela Castelló, Rocío Olmedo Requena, José Juan Jiménez Moleón, Borja María Fernández Félix, Alfonso Muriel, Marta Miret, Jose Luis Ayuso Mateos, Yoon-Hyeong Choi, Fernando Rodríguez-Artalejo, Pablo Fernández-Navarro, Esther García-Esquinas
BACKGROUND: Traffic exposure has been associated with biomarkers of increased biological ageing, age-related chronic morbidities, and increased respiratory, cardiovascular, and all-cause mortality. Whether it is associated with functional impairments and unhealthy ageing trajectories is unknown. METHODS: Nationally representative population-based cohort with 3,126 community-dwelling individuals aged ≥60 years who contributed 8,291 biannual visits over a 10 year period...
February 1, 2024: Environmental Health
https://read.qxmd.com/read/38295128/a-connection-between-the-ribosome-and-two-s-pombe-trna-modification-mutants-subject-to-rapid-trna-decay
#22
JOURNAL ARTICLE
Thareendra De Zoysa, Alayna C Hauke, Nivedita R Iyer, Erin Marcus, Sarah M Ostrowski, Franziska Stegemann, Dmitri N Ermolenko, Justin C Fay, Eric M Phizicky
tRNA modifications are crucial in all organisms to ensure tRNA folding and stability, and accurate translation. In both the yeast Saccharomyces cerevisiae and the evolutionarily distant yeast Schizosaccharomyces pombe, mutants lacking certain tRNA body modifications (outside the anticodon loop) are temperature sensitive due to rapid tRNA decay (RTD) of a subset of hypomodified tRNAs. Here we show that for each of two S. pombe mutants subject to RTD, mutations in ribosomal protein genes suppress the temperature sensitivity without altering tRNA levels...
January 31, 2024: PLoS Genetics
https://read.qxmd.com/read/38292822/serum-vitamin-d-insufficiency-is-correlated-with-quadriceps-neuromuscular-functions-in-patients-with-anterior-cruciate-ligament-injury-a-preliminary-study
#23
JOURNAL ARTICLE
Jihong Qiu, Chi-Yin Choi, Gene Chi-Wai Man, Xin He, Mingqian Yu, Mingde Cao, Qianwen Wang, Jonathan Patrick Ng, Patrick Shu-Hang Yung, Michael Tim-Yun Ong
BACKGROUND: This study aimed to investigate the correlations of serum vitamin D insufficiency with quadriceps neuromuscular function in patients with anterior cruciate ligament (ACL) injury. METHODS: A cross-sectional study was conducted. Eighteen patients with a primary, unilateral ACL injury who had insufficient serum vitamin D concentrations (<30 ng/ml) were recruited for the study. Bilateral quadriceps neuromuscular function, including maximal strength, the speed of rapid contraction, and inhibition, were measured on an isokinetic dynamometer with the hip and the knee joint flexion at 90° and 45°, respectively...
January 2024: Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology
https://read.qxmd.com/read/38278809/caspase-dependent-apoptosis-in-ribloflavin-transporter-deficiency-ipscs-and-derived-motor-neurons
#24
JOURNAL ARTICLE
Chiara Marioli, Maurizio Muzzi, Fiorella Colasuonno, Cristian Fiorucci, Nicolò Cicolani, Stefania Petrini, Enrico Bertini, Marco Tartaglia, Claudia Compagnucci, Sandra Moreno
Riboflavin Transporter Deficiency (RTD) is a rare genetic, childhood-onset disease. This pathology has a relevant neurological involvement, being characterized by motor symptoms, ponto-bulbar paralysis and sensorineural deafness. Such clinical presentation is associated with muscle weakness and motor neuron (MN) degeneration, so that RTD is considered part of the MN disease spectrum. Based on previous findings demonstrating energy dysmetabolism and mitochondrial impairment in RTD induced Pluripotent Stem cells (iPSCs) and iPSC-derived MNs, here we address the involvement of intrinsic apoptotic pathways in disease pathogenesis using these patient-specific in vitro models by combined ultrastructural and confocal analyses...
January 26, 2024: Cell Death Discovery
https://read.qxmd.com/read/38271275/antibiotic-prescribing-patterns-for-respiratory-tract-illnesses-following-the-conclusion-of-an-education-and-feedback-intervention-in-primary-care
#25
JOURNAL ARTICLE
James J Harrigan, Keith W Hamilton, Leigh Cressman, Warren B Bilker, Kathleen O Degnan, Michael Z David, David Tran, David A Pegues, Lauren Dutcher
BACKGROUND: A study previously conducted in primary care practices found that implementation of an educational session and peer comparison feedback was associated with reduced antibiotic prescribing for respiratory tract diagnoses (RTDs). Here, we assess the long-term effects of this intervention on antibiotic prescribing following cessation of feedback. METHODS: RTD encounters were grouped into tiers based on antibiotic prescribing appropriateness: tier 1, almost always indicated; tier 2, possibly indicated; and tier 3, rarely indicated...
January 25, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38255768/the-laboratory-diagnosis-of-malaria-a-focus-on-the-diagnostic-assays-in-non-endemic-areas
#26
REVIEW
Adriana Calderaro, Giovanna Piccolo, Carlo Chezzi
Even if malaria is rare in Europe, it is a medical emergency and programs for its control should ensure both an early diagnosis and a prompt treatment within 24-48 h from the onset of the symptoms. The increasing number of imported malaria cases as well as the risk of the reintroduction of autochthonous cases encouraged laboratories in non-endemic countries to adopt diagnostic methods/algorithms. Microscopy remains the gold standard, but with limitations. Rapid diagnostic tests have greatly expanded the ability to diagnose malaria for rapid results due to simplicity and low cost, but they lack sensitivity and specificity...
January 5, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38197028/effects-of-acute-sleep-deprivation-on-the-sequential-rate-of-torque-development-throughout-the-force-time-curve
#27
JOURNAL ARTICLE
André Dias Gonçalves, Pedro Pezarat-Correia, Carolina Vila-Chã, Gonçalo Vilhena Mendonça
Objective  The impact of sleep deprivation on the physiological determinants of explosive torque production remains poorly understood. We aimed at determining the acute effects of 24 hours of sleep deprivation on the sequential rate of torque development (RTD) obtained during plantar flexion through maximum voluntary isometric contraction (MVIC). Materials and Methods  The study included 14 healthy-young adults (8 men and 6 women). The participants visited the laboratory on 2 different occasions: without and with 24 hours of sleep deprivation...
December 2023: Sleep Science
https://read.qxmd.com/read/38169410/fatigue-effects-on-the-knee-flexors-neuromuscular-parameters-during-repeated-sprinting
#28
JOURNAL ARTICLE
Ricardo Pimenta, Tomás Lopes, A P Veloso
BACKGROUND: To identify at which point fatigue on neuromuscular parameters occurs in the knee flexors during a repeated sprint protocol. METHODS: Physical active males without previous hamstring strain injury were recruited. Neuromuscular parameters such as peak torque (PT) and rate of torque development (RTD) were assessed after every two sprints in a 5 × (2 x 30 m) repeated sprint protocol. RESULTS: Twenty physical active males participated in the study...
January 2, 2024: BMC Sports Science, Medicine and Rehabilitation
https://read.qxmd.com/read/38162548/electroacupuncture-roundtable-discussion
#29
JOURNAL ARTICLE
Richard C Niemtzow, Richard F Hobbs, Gerhard Litscher, John Hubacher, Jeremy V Pulsifer, Steven Rosenblatt
No abstract text is available yet for this article.
December 1, 2023: Medical Acupuncture
https://read.qxmd.com/read/38156894/data-driven-approach-to-modeling-microfabricated-chemical-sensor-manufacturing
#30
JOURNAL ARTICLE
Bradley S Chew, Nhi N Trinh, Dylan T Koch, Eva Borras, Michael K LeVasseur, Leslie A Simms, Mitchell M McCartney, Patrick Gibson, Nicholas J Kenyon, Cristina E Davis
We have developed a statistical model-based approach to the quality analysis (QA) and quality control (QC) of a gas micro pre-concentrator chip (μPC) performance when manufactured at scale for chemical and biochemical analysis of volatile organic compounds (VOCs). To test the proposed model, a medium-sized university-led production batch of 30 wafers of chips were subjected to rigorous chemical performance testing. We quantitatively report the outcomes of each manufacturing process step leading to the final functional chemical sensor chip...
December 29, 2023: Analytical Chemistry
https://read.qxmd.com/read/38137212/study-on-the-residence-time-and-texture-prediction-of-pea-protein-extrusion-based-on-image-analysis
#31
JOURNAL ARTICLE
Qi Wu, Xun Zhang, Fei Gao, Min Wu
This paper initially involves three main processing parameters: screw speed, feeding speed, and initial material moisture content, exploring the RTD of materials inside the extruder barrel under varying parameters and clarifying the impact of parameter variations on RTD. Finally, machine vision technology was utilized to link extruded product images to texture features, and a texture prediction model based on image features was established using a Back Propagation (BP) neural network. Particle Swarm Optimization (PSO) and Genetic Algorithm (GA) were applied to optimize the BP neural network...
December 7, 2023: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38132170/infrapatellar-fat-pad-modulates-osteoarthritis-associated-cytokine-and-mmp-expression-in-human-articular-chondrocytes
#32
JOURNAL ARTICLE
Ewa Wisniewska, Dominik Laue, Jacob Spinnen, Leonard Kuhrt, Benjamin Kohl, Patricia Bußmann, Carola Meier, Gundula Schulze-Tanzil, Wolfgang Ertel, Michal Jagielski
Osteoarthritis (OA) most frequently affects the knee joint and is associated with an elevated expression of cytokines and extracellular cartilage matrix (ECM), degrading enzymes such as matrix metalloproteinases (MMPs). Differences in gene expression of the intra-articularly located infrapatellar fat pad (IPFP) and other fatty tissue suggest its autonomous function, yet its role in OA pathogenesis remains unknown. Human IPFPs and articular cartilage were collected from OA patients undergoing total knee arthroplasty, and biopsies from the IPFP of healthy patients harvested during knee arthroscopy served as controls (CO)...
December 15, 2023: Cells
https://read.qxmd.com/read/38090984/the-influence-of-strength-level-on-handball-specific-fitness-elements-between-stronger-and-weaker-professional-players
#33
JOURNAL ARTICLE
Andreas Kyriacou-Rossi, Marios Hadjicharalambous, Nikolaos Zaras
Kyriacou-Rossi, A, Hadjicharalambous, M, and Zaras, N. The influence of strength level on handball-specific fitness elements between stronger and weaker professional players. J Strength Cond Res XX(X): 000-000, 2023-The aim of the study was to investigate the influence of strength level between stronger and weaker handball players on handball specific fitness elements and to explore the correlations between strength and sport-specific fitness elements. Twenty-one professional male handball-players (age: 25...
December 13, 2023: Journal of Strength and Conditioning Research
https://read.qxmd.com/read/38086121/optimizing-the-hydraulic-performance-of-a-baffled-horizontal-subsurface-flow-constructed-wetland-through-computational-fluid-dynamics-modelling
#34
JOURNAL ARTICLE
Jiahao Wei, Sarah Cotterill, Jennifer Keenahan
Baffled constructed wetlands (CWs) offer a promising solution to address low hydraulic efficiency in traditional CWs. However, there is a research gap in the field regarding the optimal length and quantity of baffles, and their comprehensive effects on hydraulic efficiency. This study is the first CFD-based assessment to comprehensively investigate the combined influence of baffle length and the number of baffles on the hydraulic efficiency of CWs. Using OpenFOAM simulations at a laboratory scale, various baffle configurations were examined with lengths ranging from 0...
December 11, 2023: Journal of Environmental Management
https://read.qxmd.com/read/38074320/relation-of-leg-phase-angle-from-bioelectrical-impedance-analysis-with-voluntary-and-evoked-contractile-properties-of-the-plantar-flexors
#35
JOURNAL ARTICLE
Kosuke Hirata, Yosuke Yamada, Natsuki Iida, Akihiro Kanda, Mikio Shoji, Tsukasa Yoshida, Ryota Akagi
Introduction: Bioelectrical impedance analysis (BIA) can noninvasively and quickly assess electrical properties of the body, such as the phase angle. Phase angle is regarded as the quantity and/or quality of skeletal muscle and is associated with exercise performance, such as jump height and walking speed. Although the phase angle derived from BIA is assumed to be a useful way to assess muscle function, the relationship between the phase angle and neuromuscular properties has not been fully investigated. The purpose of this study was to investigate the association of phase angle with voluntary and evoked contractile properties in 60 adults (age, 21-83 years; 30 females and 30 males)...
2023: Frontiers in Physiology
https://read.qxmd.com/read/38071212/raas-deficient-organoids-indicate-delayed-angiogenesis-as-a-possible-cause-for-autosomal-recessive-renal-tubular-dysgenesis
#36
JOURNAL ARTICLE
Naomi Pode-Shakked, Megan Slack, Nambirajan Sundaram, Ruth Schreiber, Kyle W McCracken, Benjamin Dekel, Michael Helmrath, Raphael Kopan
Autosomal Recessive Renal Tubular Dysgenesis (AR-RTD) is a fatal genetic disorder characterized by complete absence or severe depletion of proximal tubules (PT) in patients harboring pathogenic variants in genes involved in the Renin-Angiotensin-Aldosterone System. To uncover the pathomechanism of AR-RTD, differentiation of ACE-/- and AGTR1-/- induced pluripotent stem cells (iPSCs) and AR-RTD patient-derived iPSCs into kidney organoids is leveraged. Comprehensive marker analyses show that both mutant and control organoids generate indistinguishable PT in vitro under normoxic (21% O2) or hypoxic (2% O2) conditions...
December 9, 2023: Nature Communications
https://read.qxmd.com/read/38064743/electrical-thermal-and-noise-properties-of-platinum-carbon-free-standing-nanowires-designed-as-nanoscale-resistive-thermal-devices
#37
JOURNAL ARTICLE
Tomasz Piasecki, Krzysztof Kwoka, Ewelina Gacka, Piotr Kunicki, Teodor Gotszalk
Platinum-carbon (PtC) composite nanowires were fabricated using focused electron beam induced deposition (FEBID) and postprocessed, and their performance as a nanoscale resistive thermal device (RTD) was evaluated. Nanowires were free-standing and deposited on a dedicated substrate to eliminate the influence of the substrate itself and of the halo effect on the results. The PtC free-standing nanowires were postprocessed to lower their electrical resistance using electron beam irradiation and thermal annealing using Joule heat both separately and combined...
December 8, 2023: Nanotechnology
https://read.qxmd.com/read/38048009/fitness-to-drive-after-adult-civilian-traumatic-brain-injury-protocol-for-a-systematic-review-and-meta-analysis
#38
JOURNAL ARTICLE
Augusto Müller Fiedler, Timoteo Almeida, Fernando De Nigris Vasconcellos, Alexis Morell, Bernardo Assumpção de Monaco, Renato Anghinah, Joacir Graciolli Cordeiro
Traumatic brain injury (TBI) poses significant challenges for assessing fitness-to-drive (FTD) and determining the appropriate timing for return-to-driving (RTD) in civilian adults. This systematic review and meta-analysis protocol is designed to offer a comprehensive assessment of RTD timelines post-TBI, examining the effects of injury severity as well as demographic and clinical factors that influence driving capabilities. In response to gaps identified in previous literature-namely, the absence of recent systematic search strategies and thorough quality assessments-this study employs rigorous methodologies for literature search, data extraction, and evaluation of study quality...
December 4, 2023: Neurosurgical Review
https://read.qxmd.com/read/38040619/type-and-prevalence-of-nutrition-related-claims-on-alcoholic-ready-to-drink-beverages
#39
JOURNAL ARTICLE
Bella Sträuli, Leon Booth, Nadia Laznik, Simone Pettigrew
OBJECTIVE: To examine the extent of nutrition-related claims on ready-to-drink (RTD) alcohol products to provide insights into the types and prevalence of claims across the category. METHODS: Product type, alcohol content, and presence/type of nutrition-related claims (n=491) information was collected, March-May 2022. Chi-square analyses with pairwise z-tests were used to identify differences in claim prevalence by product type. Spearman's correlation was used to assess the relationship between alcohol content and number of claims...
November 20, 2023: Australian and New Zealand Journal of Public Health
https://read.qxmd.com/read/38014762/saliva-sampling-and-its-direct-lysis-is-an-excellent-option-for-sars-cov-2-diagnosis-in-paediatric-patients-comparison-with-the-panbio-covid-19-antigen-rapid-test-in-symptomatic-and-asymptomatic-children
#40
JOURNAL ARTICLE
Joaquín Moreno-Contreras, Marco A Espinoza, Marco A Cantú-Cuevas, Daniel A Madrid-González, Héctor Barón-Olivares, Oscar D Ortiz-Orozco, Cecilia Guzmán-Rodríguez, Carlos F Arias, Susana Lopez
Introduction. Lateral flow test (LFTs) have been used as an alternative to reverse transcription quantitative PCR (RT-qPCR) in point-of-care testing. Despite their benefits, the sensitivity of LFTs may be low and is affected by several factors. We have previously reported the feasibility of using direct lysis of individual or pools of saliva samples from symptomatic and asymptomatic patients as a source of viral genomes for detection by RT-qPCR. Hypothesis. Direct lysed saliva is more sensitive than antigen tests to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in samples from children...
November 2023: Journal of Medical Microbiology
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