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https://www.readbyqxmd.com/read/28521193/issues-raised-by-the-reference-doses-for-perfluorooctane-sulfonate-and-perfluorooctanoic-acid
#1
Zhaomin Dong, Md Mezbaul Bahar, Joytishna Jit, Bruce Kennedy, Brian Priestly, Jack Ng, Dane Lamb, Yanju Liu, Luchun Duan, Ravi Naidu
On 25th May 2016, the U.S. EPA released reference doses (RfDs) for Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoic Acid (PFOA) of 20ng/kg/day, which were much more conservative than previous values. These RfDs rely on the choices of animal point of departure (PoD) and the toxicokinetics (TK) model. At this stage, considering that the human evidence is not strong enough for RfD determination, using animal data may be appropriate but with more uncertainties. In this article, the uncertainties concerning RfDs from the choices of PoD and TK models are addressed...
May 15, 2017: Environment International
https://www.readbyqxmd.com/read/28513277/effect-of-gastrocnemius-kinesio-taping-on-countermovement-jump-performance-and-vertical-stiffness-following-muscle-fatigue
#2
Sahar Boozari, Mohammad Ali Sanjari, Ali Amiri, Ismail Ebrahimi Takamjani
CONTEXT: Kinesio Tape (KT) is a widely used intervention in the fields of sports and rehabilitation. However, its effects on lower extremity behavior during functional activities are not entirely known. OBJECTIVE: To test the hypothesis that application of KT can change performance and vertical stiffness during the countermovement jump (CMJ) before and after a fatigue protocol. DESIGN: A pre and post design to study the effect of KT in two situations, pre- and post-fatigue...
May 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28498325/the-health-risk-of-cd-released-from-low-cost-jewelry
#3
Miloslav Pouzar, Magdalena Zvolská, Oldřich Jarolím, Lenka Audrlická Vavrušová
The composition of the surface layer of 13 low-cost jewelry samples with a high Cd content was analyzed using an energy-dispersive X-ray fluorescence spectrometer (ED XRF). The analyzed jewels were obtained in cooperation with the Czech Environmental Inspectorate. The jewels were leached in two types of artificial sweat (acidic and alkaline) for 7 days. Twenty microliters of the resulting solution was subsequently placed on a paper carrier and analyzed by an LIBS (Laser-Induced Breakdown Spectrometry) spectrometer after drying...
May 12, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28486433/human-indoor-exposure-to-airborne-halogenated-flame-retardants-influence-of-airborne-particle-size
#4
Mark J La Guardia, Erika D Schreder, Nancy Uding, Robert C Hale
Inhalation of halogenated flame-retardants (HFRs) released from consumer products is an important route of exposure. However, not all airborne HFRs are respirable, and thus interact with vascular membranes within the gas exchange (alveolar) region of the lung. HFRs associated with large (>4 µm), inhalable airborne particulates are trapped on the mucosal lining of the respiratory tract and then are expelled or swallowed. The latter may contribute to internal exposure via desorption from particles in the digestive tract...
May 9, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28483548/evaluation-of-triclosan-in-minnesota-lakes-and-rivers-part-ii-human-health-risk-assessment
#5
Lisa J Yost, Timothy R Barber, P Robinan Gentry, Michael J Bock, Jennifer L Lyndall, Marie C Capdevielle, Brian P Slezak
Triclosan, an antimicrobial compound found in consumer products, has been detected in low concentrations in Minnesota municipal wastewater treatment plant (WWTP) effluent. This assessment evaluates potential health risks for exposure of adults and children to triclosan in Minnesota surface water, sediments, and fish. Potential exposures via fish consumption are considered for recreational or subsistence-level consumers. This assessment uses two chronic oral toxicity benchmarks, which bracket other available toxicity values...
August 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28466449/distribution-characterization-and-human-health-risk-assessment-of-polycyclic-aromatic-hydrocarbons-pahs-in-ovia-river-southern-nigeria
#6
Isioma Tongo, Lawrence Ezemonye, Kingsley Akpeh
The levels and distribution of polycyclic aromatic hydrocarbons (PAHs) in surface water, sediment, and fish (Clarias gariepinus) samples from Ovia River, Southern Nigeria, were evaluated, to assess the contamination profile, dietary intake, and human health risks associated with exposure. Results showed that naphthalene, acenaphthylene, and fluoranthene were the most dominant contaminant in water, sediment, and fish, respectively, with mean concentrations (μg/L) of 3.08, 45.4, and 90.7. Spatial distribution showed high occurrence of PAHs in Ekenwan, the downstream station, for all the matrices...
June 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28465071/human-health-assessment-for-long-term-oral-ingestion-of-diethylene-glycol
#7
William M Snellings, Kenneth E McMartin, Marcy I Banton, Fred Reitman, Joanna Klapacz
Diethylene glycol (DEG) is an organic chemical that is used mostly as a chemical intermediate and has minor uses as a solvent or antifreeze in consumer products; these minor uses could result in potential human exposure. Potential short and long-term human exposures also occur from misuses. The considerable reporting of DEG misuses as a substitute for other solvents in drug manufacturing and summaries of important events in the history of DEG poisonings are reviewed. Given the potential for human exposure, the disposition and toxicity of DEG were examined, and a health assessment was performed...
April 29, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28446284/-correlation-between-bone-marrow-fibrous-proliferation-and-prognosis-of-acute-myeloid-leukemia
#8
Bin Zhu, Shao-Ying Pan, Zhi-Yong Ding, Wen-Li Zhao, Ju-Hua Zhu
OBJECTIVE: To investigate the correlation between the bone marrow fibrous proliferation and the prognosis of acute myeloid leukemia(AML). METHODS: The quantitative method was used to analyze the reticulin fiber density (RFD) of AML patients. the bone marrow sections from 39 primary AML patients and 35 normal controls were collected to compare the RFD between these 2 groups. The prognosis value of RFD for AML were estimated by using appropriate statistical analysis...
April 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28445230/comparison-between-unilateral-and-bilateral-plyometric-training-on-single-and-double-leg-jumping-performance-and-strength
#9
Gregory C Bogdanis, Athanasios Tsoukos, Olga Kaloheri, Gerasimos Terzis, Panagiotis Veligekas, Lee E Brown
This study compared the effects of unilateral and bilateral plyometric training on single and double-leg jumping performance, maximal strength and rate of force development (RFD). Fifteen moderately trained subjects were randomly assigned to either a unilateral (U, n=7) or bilateral group (B, n=8). Both groups performed maximal effort plyometric leg exercises two times per week for 6 weeks. The B group performed all exercises with both legs, while the U group performed half the repetitions with each leg, so that total exercise volume was the same...
April 18, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28431618/muscle-strength-and-power-in-persons-with-multiple-sclerosis-a-systematic-review-and-meta-analysis
#10
REVIEW
Mlk Jørgensen, U Dalgas, I Wens, L G Hvid
BACKGROUND: Multiple sclerosis (MS) is a chronic disease in the central nervous system which causes a number of physical symptoms including impairments of muscle mechanical function (muscle strength, muscle power and explosive muscle strength (~rate of force development, RFD)). However, a full overview of the existing knowledge regarding muscle mechanical function in persons with MS (PwMS) is still pending. OBJECTIVES: To systematically review 1) the psychometric properties of isokinetic dynamometry testing in PwMS, and 2) studies comparing muscle mechanical function in PwMS to matched healthy controls (HC)...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28426514/comparison-of-the-hang-high-pull-and-loaded-jump-squat-for-the-development-of-vertical-jump-and-isometric-force-time-characteristics
#11
Dustin J Oranchuk, Tracey L Robinson, Zachary J Switaj, Eric J Drinkwater
Weightlifting movements have high skill demands and require expert coaching. Loaded jumps have a comparably lower skill demand, but may be similarly effective for improving explosive performance. The purpose of this study was to compare vertical jump performance, isometric force, and rate of force development (RFD) following a ten-week intervention employing the hang high-pull (hang-pull) or trap-bar jump squat (jump-squat). Eighteen NCAA Division II swimmers (8 males, 10 females) with at least one year of resistance training experience volunteered to participate...
April 15, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28421342/selective-retina-therapy-with-automatic-real-time-feedback-controlled-dosimetry-for-chronic-central-serous-chorioretinopathy-in-korean-patients
#12
Young Gun Park, Seungbum Kang, Minhee Kim, Nari Yoo, Young Jung Roh
PURPOSE: To evaluate the safety and efficacy of selective retina therapy (SRT) with real-time feedback-controlled dosimetry (RFD) in the treatment of chronic central serous chorioretinopathy (CSC). METHODS: In this retrospective case series study, 50 eyes of 49 patients with chronic CSC demonstrating focal or diffuse foveal leakages on fundus fluorescein angiography (FFA) were included. Following evaluation of test spots at temporal arcades, SRT (wavelength 527 nm, pulse repetition rate 100 Hz, pulse energy ramp with maximal 15 pulses) with retinal spot diameter of 200 μm was applied to the areas of each leakage observed on fluorescein angiography...
April 18, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28401310/the-efficacy-of-periodised-resistance-training-on-neuromuscular-adaptation-in-older-adults
#13
Jenny A Conlon, Robert U Newton, James J Tufano, Luis E Peñailillo, Harry G Banyard, Amanda J Hopper, Ashley J Ridge, G Gregory Haff
PURPOSE: This study compared the effect of periodised versus non-periodised (NP) resistance training on neuromuscular adaptions in older adults. METHODS: Forty-one apparently healthy untrained older adults (female = 21, male = 20; 70.9 ± 5.1 years; 166.3 ± 8.2 cm; 72.9 ± 13.4 kg) were recruited and randomly stratified to an NP, block periodised (BP), or daily undulating periodised (DUP) training group. Outcome measures were assessed at baseline and following a 22-week resistance training intervention (3 day week(-1)), including: muscle cross-sectional area (CSA), vertical jump performance, isometric and isokinetic peak torque, isometric rate of force development (RFD), and muscle activation...
April 11, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28394833/optimizing-half-squat-post-activation-potential-load-in-squat-jump-training-for-eliciting-relative-maximal-power-in-ski-jumpers
#14
A Gołaś, M Wilk, P Statsny, A Maszczyk, K Pajerska, A Zajac
Training load manipulation in a single workout session can increase or decrease training effectiveness in terms of athlete's strength or power gains. In ski jumping the complex training that elicits maximal power gains may take advantage of the post activation potentiation mechanism (PAP). The aim of research was to evaluate the changes in rate of force development (RFD), rate of power development (RPD) and jump height during a complex training session consisted of the barbell half squat (Sq) as an conditioning exercise with loads ranged between 60-100% of 1 repetition maximum (1RM), followed by a body weight squat jump (SqJ) as a performance task...
April 7, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28359824/development-of-biomonitoring-equivalents-for-barium-in-urine-and-plasma-for-interpreting-human-biomonitoring-data
#15
Devika Poddalgoda, Kristin Macey, Henry Assad, Kannan Krishnan
The objectives of the present work were: (1) to assemble population-level biomonitoring data to identify the concentrations of urinary and plasma barium across the general population; and (2) to derive biomonitoring equivalents (BEs) for barium in urine and plasma in order to facilitate the interpretation of barium concentrations in the biological matrices. In population level biomonitoring studies, barium has been measured in urine in the U.S. (NHANES study), but no such data on plasma barium levels were identified...
March 27, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28357493/intra-operative-multi-dimensional-fluoroscopy-of-guidepin-placement-prior-to-iliosacral-screw-fixation-for-posterior-pelvic-ring-injuries-and-sacroiliac-dislocation-an-early-case-series
#16
James C Shaw, Milton L Chip Routt, Joshua L Gary
PURPOSE: Traditional fluoroscopic techniques during percutaneous fixation of the posterior pelvic ring at times cannot adequately visualize errant or malpositioned iliosacral screws. Intra-operative fluoroscopic techniques have been advanced using multi-dimensional fluoroscopy to generate computed tomography-like images. This provides the surgeon not only the ability to assess iliosacral screw placement, but also the opportunity to assess reduction. We present a case series of four patients in which the Ziehm RFD multi-dimensional fluoroscopy was used to assess reduction and guidepin placement prior to definitive iliosacral screw fixation...
March 29, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28347455/domain-specific-effects-of-postnatal-toenail-methylmercury-exposure-on-child-behaviour
#17
Shamshad Karatela, Janis Paterson, Neil I Ward
OBJECTIVE: Very little is known about the relationship between postnatal methylmercury concentrations (via toenails as bioindicator) and behavioural characteristics of Pacific Island children living in New Zealand. The aim of this study was to explore the association between total mercury exposure and different domains of behavioural problems in Pacific children. MATERIALS AND METHODS: A sample of nine-year-old Pacific Island children resident in Auckland, New Zealand participated in this study...
May 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28340478/different-dna-damage-response-of-cis-and-trans-isomers-of-commonly-used-uv-filter-after-the-exposure-on-adult-human-liver-stem-cells-and-human-lymphoblastoid-cells
#18
Anežka Sharma, Katarína Bányiová, Pavel Babica, Naouale El Yamani, Andrew Richard Collins, Pavel Čupr
2-ethylhexyl 4-methoxycinnamate (EHMC), used in many categories of personal care products (PCPs), is one of the most discussed ultraviolet filters because of its endocrine-disrupting effects. EHMC is unstable in sunlight and can be transformed from trans-EHMC to emergent cis-EHMC. Toxicological studies are focusing only on trans-EHMC; thus the toxicological data for cis-EHMC are missing. In this study, the in vitro genotoxic effects of trans- and cis-EHMC on adult human liver stem cells HL1-hT1 and human-derived lymphoblastoid cells TK-6 using a high-throughput comet assay were studied...
March 21, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28335995/assessment-of-dietary-exposure-to-organohalogen-contaminants-legacy-and-emerging-flame-retardants-in-a-norwegian-cohort
#19
Fuchao Xu, Joo-Hui Tay, Adrian Covaci, Juan Antonio Padilla-Sánchez, Eleni Papadopoulou, Line Småstuen Haug, Hugo Neels, Ulla Sellström, Cynthia A de Wit
Polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), emerging halogenated flame retardants (EHFRs) and organophosphate flame retardants (PFRs) were detected in 24h duplicate diet samples from a Norwegian cohort (n=61), with concentrations ranging from <method limit of quantification (MLQ)-0.64ng/g ww, <MLQ-0.70ng/g ww, <MLQ-0.93ng/g ww, <MLQ-0.14ng/g ww, and <MLQ-150ng/g ww, respectively. All studied contaminants were detected in the duplicate diet samples with detection frequencies (DF) ranging from 1...
March 20, 2017: Environment International
https://www.readbyqxmd.com/read/28335559/the-optimization-and-characterization-of-an-rna-cleaving-fluorogenic-dnazyme-probe-for-mda-mb-231-cell-detection
#20
Pengcheng Xue, Shengnan He, Yu Mao, Long Qu, Feng Liu, Chunyan Tan, Yuyang Jiang, Ying Tan
Breast cancer is one of the most frequently diagnosed cancers in females worldwide and lacks specific biomarkers for early detection. In a previous study, we obtained a selective RNA-cleaving Fluorogenic DNAzyme (RFD) probe against MDA-MB-231 cells, typical breast cancer cells, through the systematic evolution of ligands by exponential process (SELEX). To improve the performance of this probe for actual application, we carried out a series of optimization experiments on the pH value of a reaction buffer, the type and concentration of cofactor ions, and sequence minimization...
March 21, 2017: Sensors
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