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Gastroenterology randomized control trial

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https://www.readbyqxmd.com/read/28381378/severe-acute-pancreatitis-pathogenesis-diagnosis-and-surgical-management
#1
Mark Portelli, Christopher David Jones
BACKGROUND: Severe acute pancreatitis is a subtype of acute pancreatitis, associated with multiple organ failure and systemic inflammatory response syndrome. In this qualitative review we looked at the principles of pathogenesis, classification and surgical management of severe acute pancreatitis. We also looked at the current shift in paradigm in the management of severe acute pancreatitis since the guideline developed by the British Society of Gastroenterology. DATA SOURCES: Studies published between 1st January 1991 and 31st December 2015 were identified with PubMed, MEDLINE, EMBASE and Google Scholar online search engines using the following Medical Subject Headings: "acute pancreatitis, necrosis, mortality, pathogenesis, incidence" and the terms "open necrosectomy and minimally invasive necrosectomy"...
April 2017: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/28374886/total-intravenous-anaesthesia-versus-inhalational-anaesthesia-for-adults-undergoing-transabdominal-robotic-assisted-laparoscopic-surgery
#2
REVIEW
Suzanne Forsyth Herling, Bjørn Dreijer, Gitte Wrist Lam, Thordis Thomsen, Ann Merete Møller
BACKGROUND: Rapid implementation of robotic transabdominal surgery has resulted in the need for re-evaluation of the most suitable form of anaesthesia. The overall objective of anaesthesia is to minimize perioperative risk and discomfort for patients both during and after surgery. Anaesthesia for patients undergoing robotic assisted surgery is different from anaesthesia for patients undergoing open or laparoscopic surgery; new anaesthetic concerns accompany robotic assisted surgery. OBJECTIVES: To assess outcomes related to the choice of total intravenous anaesthesia (TIVA) or inhalational anaesthesia for adults undergoing transabdominal robotic assisted laparoscopic gynaecological, urological or gastroenterological surgery...
April 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28293079/pediatric-gastrointestinal-bleeding-perspectives-from-the-italian-society-of-pediatric-gastroenterology
#3
REVIEW
Claudio Romano, Salvatore Oliva, Stefano Martellossi, Erasmo Miele, Serena Arrigo, Maria Giovanna Graziani, Sabrina Cardile, Federica Gaiani, Gian Luigi de'Angelis, Filippo Torroni
There are many causes of gastrointestinal bleeding (GIB) in children, and this condition is not rare, having a reported incidence of 6.4%. Causes vary with age, but show considerable overlap; moreover, while many of the causes in the pediatric population are similar to those in adults, some lesions are unique to children. The diagnostic approach for pediatric GIB includes definition of the etiology, localization of the bleeding site and determination of the severity of bleeding; timely and accurate diagnosis is necessary to reduce morbidity and mortality...
February 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28273374/acrokeratosis-paraneoplastica-bazex-syndrome-a-systematic-review-on-risk-factors-diagnosis-prognosis-and-management
#4
REVIEW
Franziska Räßler, Steven Goetze, Peter Elsner
Acrokeratosis paraneoplastica Bazex (Bazex syndrome) is a rare paraneoplastic skin disease defined by erythematous, violaceous, scaly plaques on the hands and feet and on other acral locations such as nose and ears. Bazex syndrome is linked to a variety of underlying malignancies. Usually the skin lesions develop prior to the diagnosis of an internal malignant neoplasm with spontaneous remission after tumor removal. The objective of this study was to review the so far reported risk factors, diagnostic work up, prognosis and treatment options for Bazex syndrome in a systematic manner...
March 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28270668/editorial-aspiration-therapy-for-weight-loss-is-the-squeeze-worth-the-juice
#5
Vivek Kumbhari, Patrick I Okolo Iii
There is a desperate need for a technically simple, reversible, clinically effective, and safe approach to facilitate weight loss and improvement in metabolic comorbidities in obese patients. This has led to significant investment into the development of endoscopic bariatric therapies. In this issue of the American Journal of Gastroenterology, the first randomized controlled trial assessing aspiration therapy using an endoscopically placed gastrostomy tube is reported with promising results. Aspiration therapy is the first endoscopic therapy to be approved in the United States for use in morbidly obese patients and may be an alternative to those not wishing to undergo bariatric surgery...
March 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28265892/current-approach-to-the-evaluation-and-management-of-microscopic-colitis
#6
REVIEW
Thomas G Cotter, Darrell S Pardi
PURPOSE OF REVIEW: Microscopic colitis is a common cause of chronic watery diarrhea, particularly in the elderly. The accompanying symptoms, which include abdominal pain and fatigue, can markedly impair patients' quality of life. Diagnosis is based upon characteristic histologic findings of the colonic mucosa. This review focuses on the current approach to evaluation and management of patients with microscopic colitis. RECENT FINDINGS: Although the incidence of microscopic colitis has been increasing over time, recent epidemiological studies show stabilization at 21...
February 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28214091/multidonor-intensive-faecal-microbiota-transplantation-for-active-ulcerative-colitis-a-randomised-placebo-controlled-trial
#7
Sudarshan Paramsothy, Michael A Kamm, Nadeem O Kaakoush, Alissa J Walsh, Johan van den Bogaerde, Douglas Samuel, Rupert W L Leong, Susan Connor, Watson Ng, Ramesh Paramsothy, Wei Xuan, Enmoore Lin, Hazel M Mitchell, Thomas J Borody
BACKGROUND: The intestinal microbiota is implicated in the pathogenesis of ulcerative colitis. Faecal microbiota transplantation is a novel form of therapeutic microbial manipulation, but its efficacy in ulcerative colitis is uncertain. We aimed to establish the efficacy of intensive-dosing, multidonor, faecal microbiota transplantation in active ulcerative colitis. METHODS: We conducted a multicentre, double-blind, randomised, placebo-controlled trial at three hospitals in Australia...
February 14, 2017: Lancet
https://www.readbyqxmd.com/read/27589863/the-timing-of-complementary-feeding-in-preterm-infants-and-the-effect-on-overweight-study-protocol-for-a-systematic-review
#8
Karin M Vissers, Edith J M Feskens, Johannes B van Goudoever, Arieke J Janse
BACKGROUND: In term infants, there is evidence that early complementary feeding is a risk factor for childhood obesity. Therefore, timely introduction of complementary feeding during infancy is necessary. The World Health Organization (WHO) and European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) both developed recommendations for the start of complementary feeding for term-born infants. However, these guidelines cannot be directly translated to preterm infants...
September 2, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27564646/a-critical-review-of-biosimilars-in-ibd-the-confluence-of-biologic-drug-development-regulatory-requirements-clinical-outcomes-and-big-business
#9
Christina Y Ha, Asher Kornbluth
On February 9, 2016, the Food and Drug Administration Arthritis Advisory Committee recommended by a vote of 21 to 3, that the biosimilar to infliximab, CT-P13, be approved for rheumatoid arthritis and ankylosing spondylitis and, by extrapolation, for all the indications for which infliximab is currently approved, including adult and pediatric ulcerative colitis and Crohn's disease. On April 5, 2016, the Food and Drug Administration concurred with this recommendation and approved CT-P13 (Inflectra; Pfizer Inc...
October 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27539606/liberal-versus-restrictive-fluid-management-in-abdominal-surgery-a-meta-analysis
#10
COMPARATIVE STUDY
Feng-Ju Jia, Qiao-Yuan Yan, Qi Sun, Tuerhongjiang Tuxun, Hui Liu, Li Shao
PURPOSE: This study compared perioperative restrictive fluid therapy to liberal (conventional) fluid therapy in patients undergoing major abdominal surgery and investigated the rate of post-operative morbidity (complication rates), recovery (time to flatus), and the length of hospital stay. METHODS: The Medline, PubMed, Cochrane, and EMBASE databases were searched until June 18, 2015. Randomized controlled trials, two-arm prospective studies, and retrospective studies were included in our analyses...
March 2017: Surgery Today
https://www.readbyqxmd.com/read/27501379/endoscopic-scoring-indices-for-evaluation-of-disease-activity-in-crohn-s-disease
#11
REVIEW
Reena Khanna, Sigrid A Nelson, Brian G Feagan, Geert D'Haens, William J Sandborn, G Y Zou, John K MacDonald, Claire E Parker, Vipul Jairath, Barrett G Levesque
BACKGROUND: Endoscopic assessment of mucosal disease activity is widely used to determine eligibility and response to therapy in clinical trials of treatment for Crohn's disease. However, the operating properties of the currently available endoscopic indices remain unclear. OBJECTIVES: A systematic review was undertaken to evaluate the development and operating characteristics of the Crohn's Disease Endoscopic Index of Severity (CDEIS) and Simple Endoscopic Scale for Crohn's Disease (SES-CD)...
August 8, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27437261/comparison-of-hypnotherapy-and-standard-medical-treatment-alone-on-quality-of-life-in-patients-with-irritable-bowel-syndrome-a-randomized-control-trial
#12
Korosh Shahbazi, Kamal Solati, Ali Hasanpour-Dehkordi
INTRODUCTION: Irritable bowel syndrome (IBS) is one of the most prevalent gastroenterological disorders. IBS is characterized by abdominal pain, cramping, diarrhea, constipation, bloating and flatulence. Complementary therapy is a group of diverse therapeutic and health care systems products that are used in treatment of IBS. Hypnotherapy helps to alleviate the symptoms of a broad range of diseases and conditions. It can be used independently or along with other treatments. AIM: This study was conducted to compare therapeutic effect of hypnotherapy plus standard medical treatment and standard medical treatment alone on quality of life in patients with IBS...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27372735/aminosalicylates-for-induction-of-remission-or-response-in-crohn-s-disease
#13
REVIEW
Wee-Chian Lim, Yongjun Wang, John K MacDonald, Stephen Hanauer
BACKGROUND: Randomized trials investigating the efficacy of aminosalicylates for the treatment of mildly to moderately active Crohn's disease have yielded conflicting results. A systematic review was conducted to critically examine current available data on the efficacy of sulfasalazine and mesalamine for inducing remission or clinical response in these patients. OBJECTIVES: To evaluate the efficacy of aminosalicylates compared to placebo, corticosteroids, and other aminosalicylates (alone or in combination with corticosteroids) for the treatment of mildly to moderately active Crohn's disease...
July 3, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27345654/leadership-and-team-building-in-gastrointestinal-endoscopy
#14
REVIEW
Roland M Valori, Deborah J Johnston
A modern endoscopy service delivers high volume procedures that can be daunting, embarrassing and uncomfortable for patients [1]. Endoscopy is hugely beneficial to patients but only if it is performed to high standards [2]. Some consequences of poor quality endoscopy include worse outcomes for cancer and gastrointestinal bleeding, unnecessary repeat procedures, needless damage to patients and even avoidable death [3]. New endoscopy technology and more rigorous decontamination procedures have made endoscopy more effective and safer, but they have placed additional demands on the service...
June 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27296254/effects-of-probiotic-type-dose-and-treatment-duration-on-irritable-bowel-syndrome-diagnosed-by-rome-iii-criteria-a-meta-analysis
#15
Yan Zhang, Lixiang Li, Chuanguo Guo, Dan Mu, Bingcheng Feng, Xiuli Zuo, Yanqing Li
BACKGROUND: Irritable bowel syndrome (IBS) is one of the most common functional gastroenterological diseases, affecting 11.2 % of people worldwide. Previous studies have shown that probiotic treatment may benefit IBS patients. However, the effect of probiotics and the appropriate type, dose, and treatment duration for IBS are still unclear. The aim of the current study was to assess the efficacy of different probiotic types, doses and treatment durations in IBS patients diagnosed by Rome III criteria via a meta-analysis of randomized controlled trials (RCTs)...
June 13, 2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27247222/metastatic-pancreatic-cancer-american-society-of-clinical-oncology-clinical-practice-guideline
#16
Davendra P S Sohal, Pamela B Mangu, Alok A Khorana, Manish A Shah, Philip A Philip, Eileen M O'Reilly, Hope E Uronis, Ramesh K Ramanathan, Christopher H Crane, Anitra Engebretson, Joseph T Ruggiero, Mehmet S Copur, Michelle Lau, Susan Urba, Daniel Laheru
PURPOSE: To provide evidence-based recommendations to oncologists and others for the treatment of patients with metastatic pancreatic cancer. METHODS: American Society of Clinical Oncology convened an Expert Panel of medical oncology, radiation oncology, surgical oncology, gastroenterology, palliative care, and advocacy experts to conduct a systematic review of the literature from April 2004 to June 2015. Outcomes were overall survival, disease-free survival, progression-free survival, and adverse events...
August 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27247216/locally-advanced-unresectable-pancreatic-cancer-american-society-of-clinical-oncology-clinical-practice-guideline
#17
Edward P Balaban, Pamela B Mangu, Alok A Khorana, Manish A Shah, Somnath Mukherjee, Christopher H Crane, Milind M Javle, Jennifer R Eads, Peter Allen, Andrew H Ko, Anitra Engebretson, Joseph M Herman, John H Strickler, Al B Benson, Susan Urba, Nelson S Yee
PURPOSE: To provide evidence-based recommendations to oncologists and others for treatment of patients with locally advanced, unresectable pancreatic cancer. METHODS: American Society of Clinical Oncology convened an Expert Panel of medical oncology, radiation oncology, surgical oncology, gastroenterology, palliative care, and advocacy experts and conducted a systematic review of the literature from January 2002 to June 2015. Outcomes included overall survival, disease-free survival, progression-free survival, and adverse events...
August 1, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27158477/irritable-bowel-syndrome-new-insights-into-symptom-mechanisms-and-advances-in-treatment
#18
REVIEW
Robin Spiller
Despite being one of the most common conditions leading to gastroenterological referral, irritable bowel syndrome (IBS) is poorly understood. However, recent years have seen major advances. These include new understanding of the role of both inflammation and altered microbiota as well as the impact of dietary intolerances as illuminated by magnetic resonance imaging (MRI), which has thrown new light on IBS. This article will review new data on how excessive bile acid secretion mediates diarrhea and evidence from post infectious IBS which has shown how gut inflammation can alter gut microbiota and function...
2016: F1000Research
https://www.readbyqxmd.com/read/27092708/eradication-therapy-for-peptic-ulcer-disease-in-helicobacter-pylori-positive-people
#19
REVIEW
Alexander C Ford, Kurinchi Selvan Gurusamy, Brendan Delaney, David Forman, Paul Moayyedi
BACKGROUND: Peptic ulcer disease is the cause of dyspepsia in about 10% of people. Ninety-five percent of duodenal and 70% of gastric ulcers are associated with Helicobacter pylori. Eradication of H. pylori reduces the relapse rate of ulcers but the magnitude of this effect is uncertain. This is an update of Ford AC, Delaney B, Forman D, Moayyedi P. Eradication therapy for peptic ulcer disease in Helicobacter pylori-positive patients. Cochrane Database of Systematic Reviews 2006, Issue 2...
April 19, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27091036/helicobacter-pylori-eradication-effect-on-patients-with-functional-dyspepsia-symptoms
#20
RANDOMIZED CONTROLLED TRIAL
Arezo Jodaki, Ahmad Sahraie, Masood Yasemi, Hadi Peyman, Mohamad R Yasemi, Karim Hemati
BACKGROUND: Dyspepsia is a common symptom with a broad differential diagnosis and complex pathophysiology which annually affect about 25% of the general population. Results of Helicobacter pylori eradication in the patients with dyspepsia symptoms in the different studies are controversy. Aim of the study was to evaluate the effect of Helicobacter pylori eradication in the patients with functional dyspepsia. METHODS: In order to doing the clinical trial study, demographic and clinical symptoms of the patients that referred to the gastroenterology center of the Ilam County from 1391 to 1392 was recorded in a standard questionnaire (including criteria of ROM III)...
June 2016: Minerva Gastroenterologica e Dietologica
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