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https://www.readbyqxmd.com/read/29675274/efficacy-and-safety-of-switching-prostaglandin-analog-monotherapy-to-tafluprost-timolol-fixed-combination-therapy
#1
Kazuyoshi Kitamura, Tatsuya Chiba, Fumihiko Mabuchi, Kiyotaka Ishijima, Shu Omoto, Fumiko Kashiwagi, Takashi Godo, Satoshi Kogure, Teruhiko Goto, Takashi Shibuya, Jhoji Tanabe, Shigeo Tsukahara, Tadaharu Tsuchiya, Toyoaki Tsumura, Takaharu Tokunaga, Osamu Hosaka, Tetsunori Saito, Kenji Kashiwagi
Purpose: To assess the efficacy and safety of switching from prostaglandin analog (PGA) monotherapy to tafluprost/timolol fixed-combination (Taf/Tim) therapy. Subjects and Methods: Patients with primary open-angle glaucoma, normal-tension glaucoma, or ocular hypertension who had received PGA monotherapy for at least 3 months were enrolled. Patients were examined at 1, 2, and 3 months after changing therapies. Subsequently, the patients were returned to PGA monotherapy...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29669171/prostaglandin-analogues-and-nitric-oxide-contribution-in-the-treatment-of-ocular-hypertension-and-glaucoma
#2
REVIEW
Francesco Impagnatiello, Elena Bastia, Nicoletta Almirante, Stefania Brambilla, Brigitte Duquesroix, Angela C Kothe, Michael V W Bergamini
In patients with ocular hypertension or glaucoma all treatments aim at lowering intraocular pressure (IOP) by modulating aqueous humor (AH) production and/or uveoscleral and trabecular meshwork /Schlemm's canal AH drainage. Prostaglandin (PG) analogues are considered the 'gold standard', and are the most frequently used IOP-lowering agents. Recent data support an important role of nitric oxide (NO) in regulating IOP. Thus novel PG analogues carrying a NO-donating moiety were recently advanced. Latanoprostene bunod (LBN) and NCX 470, respectively a NO-donating derivative of latanoprost and bimatoprost, are examples of such compounds...
April 18, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29667726/interventions-for-infantile-haemangiomas-of-the-skin
#3
REVIEW
Monica Novoa, Eulalia Baselga, Sandra Beltran, Lucia Giraldo, Ali Shahbaz, Hector Pardo-Hernandez, Ingrid Arevalo-Rodriguez
BACKGROUND: Infantile haemangiomas (previously known as strawberry birthmarks) are soft, raised swellings of the skin that occur in 3% to 10% of infants. These benign vascular tumours are usually uncomplicated and tend to regress spontaneously. However, when haemangiomas occur in high-risk areas, such as near the eyes, throat, or nose, impairing their function, or when complications develop, intervention may be necessary. This is an update of a Cochrane Review first published in 2011...
April 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29613980/use-of-intravitreal-bevacizumab-for-the-treatment-of-secondary-glaucoma-due-to-metastatic-iris-tumor
#4
Rukiye Aydin, Tongalp H Tezel
PURPOSE: To report the efficacy of intravitreal bevacizumab to resolve secondary angle closure glaucoma caused by biliary tract carcinoma metastasis to iris. ABSTRACT: A 52-year-old Caucasian woman who was under systemic chemotherapy for biliary tract carcinoma presented with metastatic tumor in the left iris. At presentation, her visual acuity was at 20/50 level. Tumor was occupying nasal half of the iris and had already occupied 5.5 clock hours of the angle resulting intraocular pressure elevation to 34▒mm Hg...
April 2, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29606852/switching-from-concomitant-therapy-to-tafluprost-timolol-fixed-combination
#5
Kenji Inoue, Taku Kawashima, Seiki Katakura, Kyoko Shidara, Takayuki Fujimoto, Hiromi Kohmoto, Minako Shiokawa, Ryo Moriyama, Ryoko Okayama
Purpose: To evaluate the efficacy and safety of tafluprost/timolol fixed combination (TTFC). Study design: A prospective clinical study. Methods: Twenty-eight patients (28 eyes) with primary open-angle glaucoma, who had used tafluprost and timolol gel for at least 3 months with good adherence, were enrolled. Concomitant administration of tafluprost and timolol was switched to TTFC without a washout period. The intraocular pressure (IOP), blood pressure, pulse rate, and ocular signs were compared between before switching (baseline), and 4 and 8 weeks after switching...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29600119/a-rapid-extraction-method-to-quantify-drug-uptake-in-contact-lenses
#6
Chau-Minh Phan, Sarah Weber, Jennifer Mueller, Alan Yee, Lyndon Jones
Purpose: To develop a simple extraction procedure to quantify the uptake of four topical ocular pharmaceutical drugs into contact lenses (CLs). Methods: Four silicone hydrogel (SH) CLs (balafilcon A, senofilcon A, lotrafilcon B, comfilcon B) and four conventional hydrogel (CH) CLs (nesofilcon A, hilafilcon B, nelfilcon A, etafilcon A) were evaluated. The drugs studied were natamycin, moxifloxacin, timolol maleate, and ketotifen fumarate. For drug incubation, three CLs of each type were placed in 1 mL of 1 mg/mL drug-loading solution for 24 hours...
March 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29524771/proposal-of-degradation-pathway-with-toxicity-prediction-for-hydrolytic-and-photolytic-degradation-products-of-timolol
#7
Prashant S Devrukhakar, Shiva Shankar M, Shankar G, Srinivas R
Timolol (TIM) is a potent β-adrenergic blocker, useful in treatment of ocular hypertension or open-angle glaucoma. Development and validation of stability indicating LCMS assay method for TIM was accomplished coherent with ICH guideline. Successful chromatographic separation of TIM with its four degradation products was attained by using gradient elution mode on reverse phase column using ammonium acetate buffer, pH 4.6 as mobile phase A and organic solvent as the mobile phase B. Chromatographic conditions were set such as 1...
February 28, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29520377/use-of-nd-yag-laser-to-recanalize-occluded-cypass-micro-stent-in-the-early-post-operative-period
#8
Claudio I Perez, Sunee Chansangpetch, Yen C Hsia, Shan C Lin
Purpose: To report the first case of Neodymium Yttrium Aluminum Garnet ( Nd:YAG) laser use to recanalize a CyPass occluded with a clot in the early postoperative follow-up. Observations: A 66 year-old woman with primary open angle glaucoma and cataract received combined cataract surgery plus CyPass in the right eye. Surgery was uneventful, however, there was a small amount of hyphema related to bleeding around the site of Cypass insertion. Intraocular pressure (IOP) was between 6 and 7 mmHg in the first week on no glaucoma medications...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29505672/human-secreted-proteins-slurp-1-and-slurp-2-control-the-growth-of-epithelial-cancer-cells-via-interaction-with-nicotinic-acetylcholine-receptors
#9
E N Lyukmanova, M L Bychkov, G V Sharonov, A V Efremenko, M A Shulepko, D S Kulbatskii, Z O Shenkarev, A V Feofanov, D A Dolgikh, M P Kirpichnikov
BACKGROUND AND PURPOSE: Nicotinic acetylcholine receptors (nAChRs) are a promising target for development of new anticancer therapies. Our purpose is to study effects of human proteins SLURP-1 and SLURP-2, antagonists of nAChRs, on human epithelial cancer cells. EXPERIMENTAL APPROACH: Growth of epithelial cancer cells (A431, SKBR3, MCF-7, A549, HT-29) exposed to SLURP-1, SLURP-2, mecamylamine, atropine, timolol and gefitinib was investigated by WST-1 test. Expression levels of SLURP-1, α7-nAChR and EGF receptors and their distribution in cancer cells were studied by confocal microscopy and flow cytometry...
March 5, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29505438/association-of-post-operative-topical-prostaglandin-analog-or-beta-blocker-use-and-incidence-of-pseudophakic-cystoid-macular-edema
#10
Colten Wendel, Helena Zakrzewski, Bruce Carleton, Mahyar Etminan, Frederick S Mikelberg
PURPOSE: To determine the association of post-operative topical prostaglandin analog (PGA) or topical beta-blocker use and the incidence of pseudophakic cystoid macular edema (CME). METHODS AND PATIENTS: This was a nested case control study. All adult patients who underwent cataract surgery between January 1, 2006 and December 31, 2016 and who were enrolled in the PharMetrics Plus database were eligible for inclusion. The association between post-operative topical PGAs (bimatoprost, latanoprost and travoprost/travoprost-z) or beta-blocker (betaxolol, levobunolol and timolol) use and the incidence of pseudophakic CME was assessed by conditional logistic regression...
March 2, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29497276/the-24-hour-intraocular-pressure-control-by-tafluprost-timolol-fixed-combination-after-switching-from-the-concomitant-use-of-tafluprost-and-timolol-gel-forming-solution-in-patients-with-primary-open-angle-glaucoma
#11
Kenji Nakamoto, Masahiko Takeshi, Toshihiko Hiraoka, Mayuko Eguchi, Yuichiro Nakano, Naomi Otsuka, Hiroko Hizaki, Hiromi Akai, Masayo Hashimoto
Objective: The aim of this study was to evaluate the 24-hour intraocular pressure (IOP)-control effect of the tafluprost/timolol fixed combination (TAF/TIM-FC) in patients with primary open-angle glaucoma after they switched from the concomitant use of tafluprost and timolol gel-forming solution. Patients and methods: Twenty patients with primary open-angle glaucoma (12 male and 8 female; mean ± SD age, 57.0±7.1 years) were included in this study. The patients were treated for 8 weeks with the concomitant administration of tafluprost and timolol gel-forming solution (evening dosing)...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29452108/effect-of-brimonidine-an-%C3%AE-2-adrenergic-agonist-on-human-meibomian-gland-epithelial-cells
#12
Xi Han, Yang Liu, Wendy R Kam, David A Sullivan
We recently discovered that the anti-glaucoma pharmaceuticals timolol, a β adrenergic antagonist, and pilocarpine, a cholinergic compound, negatively influence the morphology, proliferative capacity and survival of human meibomian gland epithelial cells (HMGECs). We hypothesize that another class of anti-glaucoma drugs, the α2 adrenergic agonists, also acts directly on HMGECs to affect their structure and function. We tested this hypothesis. Immortalized (i) HMGECs were cultured with brimonidine, as well as clonidine (α2 agonist), phenylephrine (α1 agonist), RX821002 (inverse α2 agonist) and MK912 (neutral α2 agonist) for up to 7 days...
February 13, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29423783/peyronie-s-disease-and-dupuytren-s-contracture-secondary-to-topical-timolol
#13
Huw Oliphant, Pieter Gouws
INTRODUCTION: Topical beta-blockers are a proven and safe medication used in the treatment of glaucoma and ocular hypertension. Local and systemic side effects are, however, well documented. Systemic side effects can include severe cardio-respiratory impairment, endocrine dysfunction, as well as headache and hyper-somnolence. Disorders involving fibrosis such as Peyronie's disease, Dupuytren's contracture, and retroperitoneal fibrosis are rarely described in the literature. CASE REPORT: We describe a case of a 55-year-old male patient undergoing treatment for ocular hypertension with topical timolol 0...
February 8, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29412149/topical-timolol-for-an-iris-hemangioma
#14
Ravali Gummi, Erin D Stahl, Justin D Marsh
No abstract text is available yet for this article.
February 2, 2018: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29401160/meibomian-gland-features-and-conjunctival-goblet-cell-density-in-glaucomatous-patients-controlled-with-prostaglandin-timolol-fixed-combinations-a-case-control-cross-sectional-study
#15
Luca Agnifili, Rodolfo Mastropasqua, Vincenzo Fasanella, Lorenza Brescia, Barbara Scatena, Francesco Oddone, Leonardo Mastropasqua
PURPOSE: To investigate, using in vivo confocal microscopy (IVCM), the Meibomian gland (MG) features and conjunctival goblet cell density (GCD) in glaucomatous patients controlled with prostaglandin/timolol fixed combinations (PTFCs). METHODS: In this cross-sectional study, sixty Caucasian patients treated with PTFCs, fifteen with latanoprost+timolol (L+T) unfixed combination, and fifteen controls were enrolled. Patients underwent the Ocular Surface Disease Index (OSDI) questionnaire, tear film break-up time (BUT), corneal staining, Schirmer test I (STI), and IVCM of MGs and goblet cells (GCs)...
February 2, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29391124/eye-drop-dispenser-type-and-medication-possession-ratio-in-patients-with-glaucoma-single-use-containers-versus-multiple-use-bottles
#16
Kun-Hoo Na, Chungkwon Yoo, Ji-Hye Park, Yong Yeon Kim
PURPOSE: To determine whether the consumption of topical glaucoma medication is influenced by the type of eye drop dispenser DESIGN: Retrospective cohort study METHODS: We examined 366 patients with open-angle glaucoma or ocular hypertension who were bilaterally treated with 0.0015% tafluprost or 2% dorzolamide/0.5% timolol fixed combination (DTFC). The patients were grouped by the type of dispenser and content of eye drops used: 1) tafluprost in bottles (T-Bottle group); 2) tafluprost in unit-dose pipettes (T-Unit group); 3) DTFC in bottles (C-Bottle group); and 4) DTFC in unit-dose pipettes (C-Unit group)...
January 29, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29373090/the-beta-2-adrenergic-receptor-antagonist-timolol-improves-healing-of-combined-burn-and-radiation-wounds
#17
Huguette Albrecht, Hsin-Ya Yang, Maija Kiuru, Saipiroon Maksaereekul, Blythe Durbin-Johnson, Michael S Wong, Thomas R Stevenson, David M Rocke, R Rivkah Isseroff
In a scenario involving a nuclear detonation during war or a terrorist attack, acute radiation exposure combined with thermal and blast effects results in severe skin injury. Although the cutaneous injury in such a scenario may not be lethal, it may lead to inflammation, delayed wound healing and loss of the skin barrier, resulting in an increased risk of infection. In this study, we tested the potential use of timolol, a beta-adrenergic receptor antagonist, to improve epidermal wound closure after combined burn and radiation injury using an ex vivo human skin culture model...
January 26, 2018: Radiation Research
https://www.readbyqxmd.com/read/29362868/effect-of-topical-timolol-on-response-rate-and-adverse-events-in-infantile-hemangioma-a-meta-analysis
#18
REVIEW
Lei Zheng, Yunling Li
A number of clinical trials evaluated the effect of topical timolol in the treatment of infantile hemangioma and provided inconsistent results. The present study assessed the response rate and adverse events of topical timolol in the treatment of infantile hemangioma. Pubmed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang, and Cochrane library were searched until October 2016. Specific inclusion criteria were used to evaluate articles. Risk ratios (RRs) with 95% confidence intervals (CIs) were calculated...
January 23, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29341922/sustained-release-timolol-maleate-loaded-ocusert-based-on-biopolymer-composite
#19
Revathy V Nair, Shefrin S, Akhil Suresh, Anoop K R, Sreeja C Nair
In the present investigation, the effect of timolol maleate loaded ocuserts was studied as an alternative for conventional anti-glaucoma formulation. Ocuserts were prepared using natural polymer sodium alginate and ethyl cellulose. Physico-chemical properties along with drug entrapment efficiency (94-98%), content uniformity (93.1% ± 0.264-98.00% ± 0.321), in vitro drug release (83.42% ± 0.35 at end of 12 hours), ex vivo permeation all showed satisfactory results, which was found to follow zero order kinetics...
January 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29319215/considerations-of-prescribers-and-pharmacists-for-the-use-of-non-selective-%C3%AE-blockers-in-asthma-and-copd-patients-an-explorative-study
#20
Esther Kuipers, Michel Wensing, Peter A G M De Smet, Martina Teichert
RATIONALE, AIMS, AND OBJECTIVES: Despite recommendations in prevailing guidelines to avoid the use of non-selective (NS) β-blockers in patients with asthma or COPD, on average, 10 patients per community pharmacy receive NS β-blockers monthly. The aim of our study was to identify the reasons of prescribers and pharmacists to treat asthma and COPD patients with NS β-blockers. METHODS: Fifty-three community pharmacists in the Netherlands selected patients with actual concurrent use of inhalation medication and NS β-blockers...
April 2018: Journal of Evaluation in Clinical Practice
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