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https://www.readbyqxmd.com/read/27913991/24-hour-efficacy-and-ocular-surface-health-with-preservative-free-tafluprost-alone-and-in-conjunction-with-preservative-free-dorzolamide-timolol-fixed-combination-in-open-angle-glaucoma-patients-insufficiently-controlled-with-preserved-latanoprost-monotherapy
#1
Anastasios-Georgios Konstas, Konstadinos G Boboridis, Paraskevas Kapis, Konstantinos Marinopoulos, Irini C Voudouragkaki, Dimitrios Panayiotou, Dimitrios G Mikropoulos, Eirini Pagkalidou, Anna-Bettina Haidich, Andreas Katsanos, Luciano Quaranta
INTRODUCTION: The aim of the present study was to evaluate the 24-h efficacy, tolerability, and ocular surface health with preservative-free (PF) tafluprost and a PF triple drug regimen comprising tafluprost and dorzolamide/timolol fixed combination (DTFC) in open-angle glaucoma patients who were insufficiently controlled with preserved branded or generic latanoprost monotherapy and who exhibited signs or symptoms of ocular surface disease (OSD). METHODS: Prospective, observer-masked, crossover, comparison...
December 2, 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27898550/severe-intraoperative-shock-related-to-mesenteric-traction-syndrome
#2
Alfredo Haack Couto, Hugo Siqueira, Pablo Pulcheira Brasileiro, Ismar Lima Cavalcanti, Rogério Luiz da Rocha Videira
Mesenteric traction syndrome is defined as arterial hypotension, facial flushing, and tachycardia related to mesenteric traction. We describe a case of mesenteric traction syndrome refractory to catecholamine and vasopressin infusions. The patient, who had Crohn disease, developed severe distributive shock after mesenteric traction while undergoing resection of an intestinal inflammatory mass, accompanied by facial flushing and unaltered readings for pulse oximetry, capnography, and bispectral index monitoring...
November 28, 2016: A & A Case Reports
https://www.readbyqxmd.com/read/27881494/a-new-uplc-method-with-chemometric-design-optimization-approach-for-the-simultaneous-quantitation-of-brimonidine-tartrate-and-timolol-maleate-in-an-eye-drop-preparation
#3
REVIEW
Eda Büker, Erdal Dinç
A new ultra-performance liquid chromatography (UPLC) with photodiode array was proposed for the quantitation of Brimonidine Tartrate (BRI) and Timolol Maleate (TIM) in eye drop using experimental design and optimization methodology. A 3(3) full factorial design was applied to uncover the effects of the selected factors and their interactions on the chromatographic response function for the optimization of experimental conditions in the development of a new UPLC method. As a result, the optimal chromatographic conditions giving a better separation and short analysis time were found to be 49...
November 23, 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27857521/global-chemical-reactivity-parameters-for-several-chiral-beta-blockers-from-the-density-functional-theory-viewpoint
#4
Mona Maria Talmaciu, Ede Bodoki, Radu Oprean
BACKGROUND AND AIM: Beta-adrenergic antagonists have been established as first line treatment in the medical management of hypertension, acute coronary syndrome and other cardiovascular diseases, as well as for the prevention of initial episodes of gastrointestinal bleeding in patients with cirrhosis and esophageal varices, glaucoma, and have recently become the main form of treatment of infantile hemangiomas. The aim of the present study is to calculate for 14 beta-blockers several quantum chemical descriptors in order to interpret various molecular properties such as electronic structure, conformation, reactivity, in the interest of determining how such descriptors could have an impact on our understanding of the experimental observations and describing various aspects of chemical binding of beta-blockers in terms of these descriptors...
2016: Clujul Medical (1957)
https://www.readbyqxmd.com/read/27846969/topical-timolol-for-chronic-wounds-in-patients-with-junctional-epidermolysis-bullosa
#5
Christine Chiaverini, Thierry Passeron, Jean-Philippe Lacour
No abstract text is available yet for this article.
December 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27835065/sustained-delivery-of-timolol-maleate-for-over-90-days-by-subconjunctival-injection
#6
Erin Lavik, Markus H Kuehn, Andrew J Shoffstall, Kristyn Atkins, Alina V Dumitrescu, Young H Kwon
PURPOSE: Medical treatment of glaucoma relies on intraocular pressure (IOP)-lowering medications, typically administered daily by the patient. While these medications are effective when applied correctly, patient adherence is a major obstacle in glaucoma treatment. We have developed a sustained-release formulation of timolol maleate that can be injected subconjunctivally to avoid patient noncompliance. METHODS: A biodegradable microsphere formulation for timolol maleate was injected subconjunctivally in normal rabbits...
November 11, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27814293/erythrocyte-nitric-oxide-in-glaucoma-patients-ex-vivo-study
#7
Rita Esteves, Teresa Freitas, Pedro Teixeira, Patrícia Napoleão, Carlos Neves, Carlota Saldanha
BACKGROUND: Glaucoma is an optic neuropathy associated with vascular dysregulation and increased intra-ocular pressure (IOP). Timolol is used as treatment for reducing IOP, by limiting aqueous humour production. Increased NOS expression as well as decreased levels of nitric oxide (NO) metabolites, and high activity of erythrocyte acetylcholinesterase (AChE) were observed in primary open angle glaucoma patients. OBJECTIVE: This ex vivo study aims to evaluate timolol effect in NO efflux and its derivatives in glaucoma patient's erythrocytes...
November 4, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27800256/transpupillary-argon-laser-cyclophotocoagulation-in-a-refractory-traumatic-glaucoma-patient-with-aphakia-and-aniridia
#8
Umut Duygu Uzunel, Berna Yüce, Tuncay Küsbeci, Halil Ateş
We present a case of transpupillary argon laser cyclophotocoagulation (TALC) in a patient with traumatic aniridia and aphakia secondary to blunt trauma who had previous bilateral trabeculectomy. Four months after the trauma the patient's intraocular pressure (IOP) rose to 35 mmHg despite topical antiglaucomatous medication. Inferior 180 degrees cyclophotocoagulation was performed with transpupillary argon laser in the first session and his IOP fell to values of 12-17 mmHg. Twelve weeks after TALC, his IOP rose to 22 mmHg and we had to apply TALC to the residual ciliary processes...
January 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27767427/effects-of-perioperative-topical-dorzolamide-hydrochloride-timolol-maleate-administration-on-incidence-and-severity-of-postoperative-ocular-hypertension-in-dogs-undergoing-cataract-extraction-by-phacoemulsification
#9
Rachel B Matusow, Ian P Herring, J Phillip Pickett, Natalia Henao-Guerrero, Stephen R Werre
OBJECTIVE To assess the effects of topically applied 2% dorzolamide hydrochloride-0.5% timolol maleate ophthalmic solution (DHTM) on incidence and severity of postoperative ocular hypertension (POH; ie, intraocular pressure [IOP] > 25 mm Hg) in dogs undergoing cataract extraction by phacoemulsification. DESIGN Randomized, masked, controlled study. ANIMALS 103 dogs (180 eyes). PROCEDURES Pertinent history, signalment, and ophthalmic examination findings were recorded. Dogs received 1 drop of DHTM or sham treatment solution (sterile, buffered, isotonic eye drops) in both eyes 14 hours and 2 hours before anesthetic induction and at the time of corneal incision closure (ie, end of surgery); IOPs were assessed by rebound tonometry 2, 4, 6, and 8 hours after surgery and between 7:30 and 8:00 am on the following day...
November 1, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27760378/bioadhesive-chitosan-loaded-liposomes-a-more-efficient-and-higher-permeable-ocular-delivery-platform-for-timolol-maleate
#10
Guoxin Tan, Shihui Yu, Hao Pan, Jinyu Li, Dandan Liu, Kun Yuan, Xinggang Yang, Weisan Pan
The aim of this study was to develop and characterize a novel colloidal system, namely, timolol maleate chitosan coated liposomes (TM-CHL) to enhance the ocular permeation, precorneal residence time and bioavailability. The resulting TM-CHL was the most promising formulation with a mean particle size of 150.7nm and an EE% of 75.83±1.61%. In vitro release of the TM-CHL showed an extended drug release profile. The TM-CHL exhibited significant mucin adhesion and compared with commercial eye drops, TM-CHL produced a 3...
October 17, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27703324/preservative-free-bimatoprost-0-03-timolol-0-5-fixed-combination-in-patients-with-glaucoma-in-clinical-practice
#11
Stefan Pfennigsdorf, Peter Eschstruth, Stefan Häsemeyer, Cord Feuerhake, Gerrett Brief, Ioana Grobeiu, Andrew Shirlaw
PURPOSE: The aim of this study was to evaluate the efficacy and tolerability of, and compliance to, preservative-free (PF), fixed-combination (FC) bimatoprost 0.03%/timolol 0.5% in patients with primary open-angle glaucoma or ocular hypertension in a clinical practice setting. PATIENTS AND METHODS: This open-label study observed patients switched to PF FC bimatoprost 0.03%/timolol 0.5% due to insufficient intraocular pressure (IOP) control on previous therapies...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27678247/ocular-drug-delivery-through-phema-hydrogel-contact-lenses-co-loaded-with-lipophilic-vitamins
#12
Dasom Lee, Seungkwon Cho, Hwa Sung Park, Inchan Kwon
Ocular drug delivery through hydrogel contact lenses has great potential for the treatment of ocular diseases. Previous studies showed that the loading of lipophilic vitamin E to silicone-hydrogel contact lenses was beneficial in ocular drug delivery. We hypothesized that vitamin E loading to another type of popular hydrogel contact lenses, pHEMA-hydrogel contact lenses, improves ocular drug delivery by increasing the drug loading or the duration of drug release. Loading of vitamin E to pHEMA-hydrogel contact lenses significantly increased the loading of a hydrophilic drug surrogate (Alexa Fluor 488 dye) and two hydrophilic glaucoma drugs (timolol and brimonidine) to the lenses by 37...
September 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27664023/extended-wear-therapeutic-contact-lens-fabricated-from-timolol-imprinted-carboxymethyl-chitosan-g-hydroxy-ethyl-methacrylate-g-poly-acrylamide-as-a-onetime-medication-for-glaucoma
#13
T S Anirudhan, Anoop S Nair, J Parvathy
An extended wear therapeutic contact lens (TCL) for the sustained delivery of timolol maleate (TML) was fabricated based on molecular imprinting technique. The designed TCL comprised of a TML imprinted copolymer of carboxymethyl chitosan-g-hydroxy ethyl methacrylate-g-polyacrylamide (CmCS-g-HEMA-g-pAAm) embedded onto a poly HEMA matrix (pHEMA). Successful reloading of TML onto the lens was monitored using a simple and novel UV-Visible spectrophotometric method which showed an excellent reloading capacity of 6...
December 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27660724/improved-bioavailability-of-timolol-maleate-via-transdermal-transfersomal-gel-statistical-optimization-characterization-and-pharmacokinetic-assessment
#14
Nadia M Morsi, Ahmed A Aboelwafa, Marwa H S Dawoud
Timolol maleate (TiM), a nonselective β-adrenergic blocker, is a potent highly effective agent for management of hypertension. The drug suffers from extensive first pass effect, resulting in a reduction of oral bioavailability (F%) to 50% and a short elimination half-life of 4 h; parameters necessitating its frequent administration. The current study was therefore, designed to formulate and optimize the transfersomal TiM gel for transdermal delivery. TiM loaded transfersomal gel was optimized using two 2(3) full factorial designs; where the effects of egg phosphatidyl choline (PC): surfactant (SAA) molar ratio, solvent volumetric ratio, and the drug amount were evaluated...
September 2016: Journal of Advanced Research
https://www.readbyqxmd.com/read/27612621/prolonged-ocular-inflammation-in-endotoxin-induced-uveitis-in-lysosomal-phospholipase-a2-deficient-mice
#15
Kanako Sawada, Miki Hiraoka, Akira Abe, Robert Kelly, James A Shayman, Hiroshi Ohguro
PURPOSE: The goal of present study was to elucidate the pathophysiological roles of lysosomal phospholipase A2 (LPLA2) in intraocular pressure (IOP) levels and ocular inflammation. METHODS: C57BL/6 (wild-type) and LPLA2-deficient mice with C57BL/6 background were employed. The IOPs were compared between wild-type and LPLA2-deficient mice during their aging, after topical administration of antiglaucoma medications such as travoprost, dorzolamide, or timolol maleate, or after induction of endotoxin-induced uveitis (EIU) using lipopolysaccharide (LPS)...
September 9, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27611484/enhancement-of-ocular-in-situ-gelling-properties-of-low-acyl-gellan-gum-by-use-of-ion-exchange
#16
Kenneth Reed, Amy Li, Britney Wilson, Tetchi Assamoi
PURPOSE: The purpose of this study was to determine if the addition of calcium gluconate to gellan solution results in a stronger gel structure on initial exposure to tear fluid due to the displacement of calcium from the gluconate ion by tear monovalent cations (Na(+), K(+)). METHODS: Test solutions of gellan and gellan-calcium gluconate were mixed thoroughly with simulated tear fluid (STF) at a 5:1 ratio. The resulting gel was measured for viscosity at 32°C-36°C...
September 9, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27592104/topical-timolol-maleate-0-5-for-infantile-hemangioma-its-effectiveness-compared-to-ultrapotent-topical-corticosteroids-a-single-center-experience-of-278-cases
#17
Retno Danarti, Lukman Ariwibowo, Sunardi Radiono, Arief Budiyanto
BACKGROUND: Infantile hemangioma (IH) may have implications on parental distress and cosmetic disfigurement. To date, ultrapotent corticosteroids are used as a treatment of choice for superficial IH. However, due to their side effects and sometimes lack of IH regression, it is necessary to find alternative topical therapies. Timolol maleate 0.5% solution and gel are nonselective β-blockers that could inhibit proliferation and trigger regression of IH. OBJECTIVE: To evaluate the efficacy of topical ultrapotent corticosteroids and timolol maleate 0...
September 3, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27588127/evaluation-of-the-efficacy-and-safety-of-topical-timolol-maleate-combined-with-oral-propranolol-treatment-for-parotid-mixed-infantile-hemangiomas
#18
Shuang Tong, Da-Peng Xu, Zi-Mei Liu, Yang Du, Xu-Kai Wang
The aim of the present study was to assess the efficacy and safety of topical timolol maleate combined with oral propranolol for parotid infantile hemangiomas. Between October 2012 and April 2014, propranolol was administered orally at a dose of 1.0-1.5 mg/kg/day to 22 infants with proliferating hemangiomas in the Department of Oral and Maxillofacial Surgery (Hospital of Stomatology, China Medical University, Shenyang, Liaoning, China). A small amount of 0.5% timolol maleate eye drop solution was topically applied with medical cotton swabs to the area of the lesion twice a day, every 12 h...
September 2016: Oncology Letters
https://www.readbyqxmd.com/read/27545615/alopecia-induced-by-timolol-eye-drops
#19
Ken Muramatsu, Toshifumi Nomura, Chihiro Shiiya, Keiko Nishiura, Ichiro Tsukinaga
is missing (Short communication).
August 22, 2016: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/27543231/timolol-for-the-treatment-of-pyogenic-granuloma-pg-in-children
#20
Nicole Knöpfel, Maria Del Mar Escudero-Góngora, Ana Bauzà, Ana Martín-Santiago
No abstract text is available yet for this article.
September 2016: Journal of the American Academy of Dermatology
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