keyword
MENU ▼
Read by QxMD icon Read
search

Timolol

keyword
https://www.readbyqxmd.com/read/28820646/consequences-of-puberty-on-efficacy-of-intraocular-pressure-lowering-drugs-in-male-dutch-belted-rabbits
#1
Cassandra L Hays, Kingsley C Okafor, Shan Fan, Robin High, Dhirendra P Singh, Carol B Toris
PURPOSE: To investigate the changes in intraocular pressure (IOP), aqueous flow, and outflow facility, as well as efficacy of IOP-lowering drugs before and after sexual development in rabbits. METHODS: Male Dutch-belted rabbits were studied at night between the ages of 8 and 44 weeks. During these times, body weight, testicular volume, and serum testosterone were measured to monitor sexual maturity. Ocular measurements included anterior chamber depth, central corneal thickness, IOP, aqueous flow, and outflow facility...
August 18, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28790802/the-signs-of-ocular-surface-disorders-after-switching-from-latanoprost-to-tafluprost-timolol-fixed-combination-a-prospective-study
#2
Hideaki Okumichi, Yoshiaki Kiuchi, Tetsuya Baba, Takashi Kanamoto, Tomoko Naito, Shunsuke Nakakura, Hitoshi Tabuchi, Hiroki Nii, Chie Sueoka, Yosuke Sugimoto
PURPOSE: To evaluate the ocular-surface safety of a 0.001% benzalkonium chloride-containing tafluprost/timolol fixed combination (TTFC) in patients with primary open-angle glaucoma (POAG) or ocular hypertension who have inadequate intraocular pressure (IOP) control with latanoprost monotherapy. METHODS: This study is a multicenter, prospective, single-arm, open-label clinical study. Patients with POAG or ocular hypertension who have inadequate IOP control with latanoprost monotherapy were considered eligible...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28768500/long-term-safety-and-tolerability-of-tafluprost-0-0015-vs-timolol-0-1-preservative-free-in-ocular-hypertensive-and-in-primary-open-angle-glaucoma-patients-a-cross-sectional-study
#3
Teresa Rolle, Roberta Spinetta, Raffaele Nuzzi
BACKGROUND: The effects of preservatives of antiglaucoma medications on corneal surface and tear function have been widely shown in literature; it's not the same as regards the active compounds themselves. The purpose of our study was to compare Ocular Surface Disease (OSD) signs and symptoms of Tafluprost 0.0015% versus preservative free (PF) Timolol 0.1% eyedrops in ocular hypertensive (OH) and in primary open-angle glaucoma (POAG) patients. METHODS: A cross-sectional study included patients in monotherapy for at least 36 months with Tafluprost 0...
August 3, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28761845/angiolymphoid-hyperplasia-with-eosinophilia-and-its-response-to-the-combination-of-radiofrequency-ablation-and-topical-timolol
#4
Pooja Arora, Neha Meena, Prafulla K Sharma, Minakshi Bhardwaj
Angiolymphoid hyperplasia with eosinophilia is a rare vascular disease characterized by multiple erythematous to violaceous papules, commonly present on the head and neck region. We report a case of a 23-year-old female who presented with multiple, erythematous asymptomatic papules on the preauricular region and pinna, which on biopsy was suggestive of angiolymphoid hyperplasia. The lesions were treated with a novel combination of radiofrequency ablation and topical timolol. The lesions healed without scarring and there was no recurrence on 1 year follow up...
July 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28761569/efficacy-and-safety-of-switching-from-prostaglandin-analog-therapy-to-prostaglandin-timolol-fixed-combination-or-prostaglandin-brimonidine-therapy
#5
Kenji Inoue, Mieko Masumoto, Kyoko Ishida, Goji Tomita
BACKGROUND: To compare the safety and efficacy between switching to prostaglandin/timolol fixed combination eye drops (PG/timolol FCs) and adding brimonidine to PG analogue monotherapy. METHODS: Eyes of 53 patients with primary open-angle glaucoma or ocular hypertension who were receiving PG analogue monotherapy were included. Participants were randomly divided into two treatment groups: one was prescribed PG/timolol FCs (switched group), and for the other, 0.1% brimonidine was added to the PG analogue (added group)...
2017: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/28719370/simple-preparation-of-timolol-0-5-gel-from-eye-drop-solution-for-superficial-infantile-hemangiomas
#6
Winnie Choo
The discovery of beta-adrenergic blocker effects on infantile hemangiomas has affected the choice of treatment in recent years. Oral propranolol is effective in treating infantile hemangiomas, but the risk of systemic side effects remains a concern. Data from literature review reported positive clinical outcomes with no major adverse effects observed in children using topical beta-blocker such as timolol maleate. Topical application of timolol eye drop has been mentioned in few studies, most of which reported that the solution cannot stay on the site of application due to its fluidity...
July 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28702374/topical-application-of-0-5-timolol-maleate-hydrogel-for-the-treatment-of-superficial-infantile-hemangioma
#7
Hai Wei Wu, Chao Liu, Xuan Wang, Ling Zhang, Weien Yuan, Jia Wei Zheng, Li Xin Su, Xin Dong Fan
The therapeutic options for infantile hemangiomas (IHs) have been greatly altered since the introduction of oral propranolol for successful treatments of IHs. Recently, there is an increase in the application of topical timolol maleate for treating superficial IHs. In the present study, we developed a new formulation of timolol maleate 0.5% hydrogel and treated 321 patients with superficial IHs to evaluate its efficacy and safety in the treatment of superficial IHs. This new timolol hydrogel was applied three times daily with a mean duration of 7...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28699051/-assessing-the-added-benefit-of-new-ophthalmic-drugs-which-additional-insights-can-be-extracted-from-the-early-benefit-assessment
#8
REVIEW
M Appelrath, G Glaeske
Until now six ophthalmic agents have undergone the German early benefit assessment according to § 35a Social Security Code (SGB) V in a total of eleven indications. Only one agent (ocriplasmin) was recognized by the Federal Joint Committee as having an added benefit based on submitted study data for a subpopulation (indication of a considerable added benefit, limited for 5 years) and another agent, idebenone, received an added benefit due to its orphan drug designation (proof of a not quantifiable added benefit, limited for 2 years)...
July 11, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28690223/-usage-and-efficacy-of-timolol-maleate-eye-drops-in-treatment-of-superficial-infantile-hemangioma
#9
Qizhen Wu, Qingmei Shi, Jianhong Long, Jiaguang Li, Yu Guo, Shaorong Lei
To determine drug dose and usage of timolol maleate eye drops in the treatment of superficial infantile hemangioma.
 Methods: A total of 250 superficial hemangioma infants were recruited and assigned into 5 groups (n=50 for each group): an external application group and 4 exterior coating groups (2, 4, 6, 8 times per day). We evaluated the therapeutic effect of different methods for drug application (external application or exterior coating) and the frequency for drug administration on superficial infantile hemangioma...
June 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28677301/topical-timolol-for-treatment-of-penile-kaposi-sarcoma-in-hiv-negative-patient
#10
L Sainz-Gaspar, J M Suárez-Peñaranda, M Pousa-Martínez, H Vázquez-Veiga, V Fernández-Redondo
No abstract text is available yet for this article.
July 4, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28674856/brimonidine-timolol-versus-brinzolamide-timolol-for-treatment-of-elevated-intraocular-pressure-after-phacoemulsification-surgery
#11
Selahattin Balsak, Ayhan Kaydu, Seyfettin Erdem, M Fuat Alakus, Zeynep Gursel Ozkurt
PURPOSE: To compare the efficacy of the fixed combination of brimonidine-timolol (FCBT) and the fixed combination of brinzolamide-timolol (FCBZT) treatments for elevated intraocular pressure (IOP) after phacoemulsification cataract surgery. METHODS: A randomised, prospective, double-blinded study was conducted on 277 eyes of 257 patients who underwent phacoemulsification cataract surgery. Patients were divided into three groups based on the medication administered after cataract surgery as follows: FCBT, FCBZT and a control group where no antiglaucoma medications were used...
July 3, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28671925/ophthalmic-timolol-hallucinations-a-case-series-and-review-of-the-literature
#12
Tavish Nanda, Nailyn Rasool, Alison B Callahan, Robert L Stamper, Jeffrey G Odel
PURPOSE: Systemic absorption and central nervous system (CNS) penetration of timolol drops are a well-studied phenomenon, resulting in common side effects such as bradycardia, bronchospasm, fatigue, and confusion. More serious CNS side effects, such as psychosis and depression, however, are rarely attributed to eye drops. We report a case series in which patients developed visual hallucinations secondary to topical ocular timolol use. METHODS: This study is a case series and review of the literature...
June 30, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28660677/variability-of-delivery-of-timolol-for-the-treatment-of-infantile-hemangiomas
#13
JiaDe Yu, Tucker Keuter, Kala Schilter, Marcia Seefeldt, Brittney Bates, Katherine Mueller, Beth A Drolet
BACKGROUND/OBJECTIVES: Topical timolol maleate solution or gel-forming solution is used alone or in conjunction with oral propranolol for the treatment of infantile hemangiomas. The consistency of the amount of timolol dispensed has never been evaluated. We evaluated the variability of drug delivery between different brands and formulations of timolol solution and gel-forming solution. METHODS: Five blinded volunteers sequentially dispensed five drops from each of the eight bottles containing timolol 0...
July 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28655605/gadolinium-enhanced-7-0%C3%A2-t-magnetic-resonance-imaging-assessment-of-the-aqueous-inflow-in-rat-eyes-in%C3%A2-vivo
#14
Lu Li, Yuxiang Yuan, Liwen Chen, Mu Li, Pingting Ji, Jieling Gong, Yin Zhao, Hong Zhang
The goal of this study was to calculate the anterior chamber volume and assess aqueous inflow in rat eyes in vivo, under anesthetic condition. Gadolinium-contrast agent (Gd-DTPA, 234.5 mg/ml) was administered to Sprague-Dawley rat eyes via anterior chamber injection or instillation of 234.5 or 117.25 mg/ml Gd-DTPA in 0.2% azone as eye drops, and changes of Gd signal visualized by 7.0 T magnetic resonance imaging (MRI). The safety of local application of Gd-DTPA and azone were performed after MRI scanning...
September 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28652689/preservative-free-fixed-combination-of-tafluprost-0-0015-and-timolol-0-5-in-patients-with-open-angle-glaucoma-and-ocular-hypertension-results-of-an-open-label-observational-study
#15
Lutz E Pillunat, Carl Erb, Auli Ropo, Friedemann Kimmich, Norbert Pfeiffer
BACKGROUND: Efficacy, tolerability and safety of the novel preservative-free fixed combination of tafluprost 0.0015%/timolol 0.5% (Taptiqom(®)) were investigated in an observational study in Germany. OBJECTIVE: To assess efficacy, tolerability and safety of the preservative-free fixed combination of tafluprost 0.0015%/timolol 0.5% in a real-life setting. METHODS: Intraocular pressure (IOP) was recorded for each eye at baseline (any previous therapy or untreated) and 4-16 weeks after changing medical treatment to or initiating treatment with the preservative-free fixed combination of tafluprost 0...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28652172/enhancement-and-inhibition-effects-on-the-corneal-permeability-of-timolol-maleate-polymers-cyclodextrins-and-chelating-agents
#16
Isabel Rodríguez, José Antonio Vázquez, Lorenzo Pastrana, Vitaliy V Khutoryanskiy
This study investigates how both bioadhesive polymers (chitosan, hyaluronic acid and alginate) and permeability enhancers (ethylene glycol- bis(2-aminoethylether)- N, N, N', N'- tetraacetic acid (EGTA) and hydroxypropyl-ß-cyclodextrin) influence the permeability of the anti-glaucoma drug timolol maleate through ex vivo bovine corneas. Our results showed that only the permeability enhancers alone were able to increase drug permeability, whereas the polymers significantly reduced drug permeation, and however, they increased the pre-corneal residence of timolol...
June 23, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28633284/determination-of-some-%C3%AE-blockers-and-%C3%AE-2-agonists-in-plasma-and-urine-using-liquid-chromatography-tandem-mass-spectrometry-and-solid-phase-extraction
#17
Alaa A Salem, Ibrahim Wasfi, Salama S Al-Nassib, Mahmoud Allawy Mohsin, Nawal Al-Katheeri
A highly sensitive method for the determinations of acebutolol, clenbuterol, nadolol, oxprenolol, propranolol, terbutaline and timolol β-blockers and β2-agonists in plasma and urine was developed. The method was optimized using electrospray ionization liquid chromatography-tandem mass spectrometry (LC-ESI-MS-MS) and clean screen solid phase extraction cartridges. Matrix effect was reduced by removing co-extractives from the SPE cartridges using methanol prior to drugs' elution. Using blood and serum matrices for calibration and applying the internal standard method has also contributed to the reduction of matrix effect...
June 13, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28627456/effect-of-the-surface-layer-on-drug-release-from-delefilcon-a-dailies-total1-%C3%A2-contact-lenses
#18
Phillip Dixon, Anuj Chauhan
Contact lenses are receiving significant attention for delivering ophthalmic drugs with higher bioavailability compared to eye drops. Here we explore drug transport from delefilcon-A Dailies Total1(®) lenses which are designed to have a thin, high-water content layer on the surface. Our goal is to determine the impact of this high water content layer on drug transport for both hydrophobic (dexamethasone and cyclosporine) and hydrophilic (timolol and levofloxacin) drugs. Drugs were loaded into the lens by soaking in aqueous drug solutions till equilibrium, followed by release in phosphate buffered saline...
June 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28625688/electrically-atomised-formulations-of-timolol-maleate-for-direct-and-on-demand-ocular-lens-coatings
#19
Prina Mehta, Ali Al-Kinani, Rita Haj-Ahmad, Muhammad Sohail Arshad, Ming-Wei Chang, G Raid Alany, Zeeshan Ahmad
Advances in nanotechnology have enabled solutions for challenging drug delivery targets. While the eye presents numerous emerging opportunities for delivery, analysis and sensing; issues persist for conventional applications. This includes liquid phase formulation localisation on the ocular surface once administered as formulated eye-drops; with the vast majority of dosage (>90%) escaping from the administered site due to tear production and various drainage mechanisms. The work presented here demonstrates a single needle electrohydrodynamic (EHD) engineering process to nano-coat (as an on demand and controllable fiber depositing method) the surface of multiple contact lenses rendering formulations to be stationary on the lens and at the bio-interface...
June 15, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28616797/the-efficacy-and-safety-of-bimatoprost-timolol-maleate-latanoprost-timolol-maleate-and-travoprost-timolol-maleate-fixed-combinations-on-24-h-iop
#20
Suzan Guven Yilmaz, Cumali Degirmenci, Yunus Emre Karakoyun, Emil Yusifov, Halil Ates
PURPOSE: To evaluate the effect of bimatoprost/timolol maleate fixed combination (BTFC), latanoprost/timolol maleate fixed combination (LTFC), and travoprost/timolol maleate fixed combination (TTFC) on 24-h intraocular pressure (IOP) in patients with open-angle glaucoma. METHODS: This prospective, observer-masked, randomized study included 50 patients with primary open-angle glaucoma. All patients were using hypotensive lipids and timolol maleate fixed combination treatment for ≥4 weeks and had an IOP ≤ 21 mmHg...
June 14, 2017: International Ophthalmology
keyword
keyword
26347
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"