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https://www.readbyqxmd.com/read/28633284/determination-of-some-%C3%AE-blockers-and-%C3%AE-2-agonists-in-plasma-and-urine-using-liquid-chromatography-tandem-mass-spectrometry-and-solid-phase-extraction
#1
Alaa A Salem, Ibrahim Wasfi, Salama S Al-Nassib, Mahmoud Allawy Mohsin, Nawal Al-Katheeri
A highly sensitive method for the determinations of acebutolol, clenbuterol, nadolol, oxprenolol, propranolol, terbutaline and timolol β-blockers and β2-agonists in plasma and urine was developed. The method was optimized using electrospray ionization liquid chromatography-tandem mass spectrometry (LC-ESI-MS-MS) and clean screen solid phase extraction cartridges. Matrix effect was reduced by removing co-extractives from the SPE cartridges using methanol prior to drugs' elution. Using blood and serum matrices for calibration and applying the internal standard method has also contributed to the reduction of matrix effect...
June 13, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28627456/effect-of-the-surface-layer-on-drug-release-from-delefilcon-a-dailies-total1-%C3%A2-contact-lenses
#2
Phillip Dixon, Anuj Chauhan
Contact lenses are receiving significant attention for delivering ophthalmic drugs with higher bioavailability compared to eye drops. Here we explore drug transport from delefilcon-A Dailies Total1(®) lenses which are designed to have a thin, high-water content layer on the surface. Our goal is to determine the impact of this high water content layer on drug transport for both hydrophobic (dexamethasone and cyclosporine) and hydrophilic (timolol and levofloxacin) drugs. Drugs were loaded into the lens by soaking in aqueous drug solutions till equilibrium, followed by release in phosphate buffered saline...
June 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28625688/electrically-atomised-formulations-of-timolol-maleate-for-direct-and-on-demand-ocular-lens-coatings
#3
Prina Mehta, Ali Al-Kinani, Rita Haj-Ahmad, Muhammad Sohail Arshad, Ming-Wei Chang, G Raid Alany, Zeeshan Ahmad
Advances in nanotechnology have enabled solutions for challenging drug delivery targets. While the eye presents numerous emerging opportunities for delivery, analysis and sensing; issues persist for conventional applications. This includes liquid phase formulation localisation on the ocular surface once administered as formulated eye-drops; with the vast majority of dosage (>90%) escaping from the administered site due to tear production and various drainage mechanisms. The work presented here demonstrates a single needle electrohydrodynamic (EHD) engineering process to nano-coat (as an on demand and controllable fiber depositing method) the surface of multiple contact lenses rendering formulations to be stationary on the lens and at the bio-interface...
June 15, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28616797/the-efficacy-and-safety-of-bimatoprost-timolol-maleate-latanoprost-timolol-maleate-and-travoprost-timolol-maleate-fixed-combinations-on-24-h-iop
#4
Suzan Guven Yilmaz, Cumali Degirmenci, Yunus Emre Karakoyun, Emil Yusifov, Halil Ates
PURPOSE: To evaluate the effect of bimatoprost/timolol maleate fixed combination (BTFC), latanoprost/timolol maleate fixed combination (LTFC), and travoprost/timolol maleate fixed combination (TTFC) on 24-h intraocular pressure (IOP) in patients with open-angle glaucoma. METHODS: This prospective, observer-masked, randomized study included 50 patients with primary open-angle glaucoma. All patients were using hypotensive lipids and timolol maleate fixed combination treatment for ≥4 weeks and had an IOP ≤ 21 mmHg...
June 14, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28602502/extent-of-the-influence-of-phosphate-buffer-and-ionic-liquids-on-the-reduction-of-the-silanol-effect-in-a-c18-stationary-phase
#5
S Carda-Broch, M C García-Alvarez-Coque, M J Ruiz-Angel
The presence of anionic free silanols in the silica-based stationary phases gives rise to broad and asymmetrical peaks when cationic basic compounds are chromatographed using hydro-organic mobile phases. The addition to the mobile phase of a reagent with ionic character prevents the access of analytes to the free silanols, improving the peak shape. The silanol activity can be affected by the buffer concentration and mobile phase pH, factors that are not always considered sufficiently in the literature. In this work, the chromatographic behaviour of three basic β-adrenoceptor antagonists (acebutolol, nadolol and timolol), using mobile phases containing acetonitrile, was examined at different phosphate buffer concentrations (5-50mM) and mobile phase pH (2-8), in the absence and presence of three imidazolium-based ionic liquids (1-ethyl-, 1-butyl- and 1-hexyl-3-methylimidazolium chloride)...
June 1, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28548465/assessment-of-infantile-hemangiomas-using-a-handheld-wireless-diffuse-optical-spectroscopic-device
#6
Christopher J Fong, Maria C Garzon, Jennifer W Hoi, Hyun K Kim, Christine T Lauren, Kimberly Morel, Lauren Geller, Nina Antonov, Nicole Weitz, June Wu, Andreas H Hielscher
BACKGROUND/OBJECTIVES: Infantile hemangiomas (IHs) are vascular tumors with the potential for significant morbidity. There is a lack of validated objective tools to assess IH severity and response to treatment. Diffuse optical spectroscopy (DOS), a noninvasive, nonionizing imaging modality, can measure total hemoglobin concentration and hemoglobin oxygen saturation in tissue to assess IH vascularity and response to treatment. Our objective was to evaluate the utility of a wireless, handheld DOS system to assess IH characteristics at selected points during their clinical course...
May 26, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28543755/comparison-of-two-formulations-of-topical-timolol-for-the-treatment-of-infantile-hemangiomas
#7
Michelle Si Ying Ng, Yong-Kwang Tay, Shanna Shan-Yi Ng, Alice Yee Wah Foong, Mark Jean-Aan Koh
This report compares the efficacy of timolol maleate 0.5% eyedrops (TM) with that of timolol maleate 0.5% ophthalmic gel-forming solution in the treatment of infantile hemangiomas (IHs). Sixty-six patients undergoing treatment with topical timolol were retrospectively reviewed; our results revealed similar therapeutic efficacies for both types of timolol formulations. Early treatment initiation (<3 mos) and superficial lesions correlated with better treatment response. TM eyedrops may be a more cost effective, equally efficacious modality of treatment for IHs...
May 25, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28540083/additive-intraocular-pressure-lowering-effects-of-ripasudil-with-glaucoma-therapeutic-agents-in-rabbits-and-monkeys
#8
Yoshio Kaneko, Masayuki Ohta, Tomoyuki Isobe, Yuto Nakamura, Ken Mizuno
Ripasudil hydrochloride hydrate (K-115), a specific Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor, is developed for the treatment of glaucoma and ocular hypertension. Topical administration of ripasudil decreases intraocular pressure (IOP) by increasing conventional outflow through the trabeculae to Schlemm's canal, which is different from existing agents that suppress aqueous humor production or promote uveoscleral outflow. In this study, we demonstrated that ripasudil significantly lowered IOP in combined regimens with other glaucoma therapeutic agents in rabbits and monkeys...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28532033/synthesis-of-nano-sized-timolol-imprinted-polymer-via-ultrasonication-assisted-suspension-polymerization-in-silicon-oil-and-its-use-for-the-fabrication-of-timolol-voltammetric-sensor
#9
Taher Alizadeh, Mohammad Reza Ganjali, Faride Rafiei, Maedeh Akhoundian
A novel timolol voltammetric sensor based on the nano-sized molecularly imprinted polymer (nano-MIP)-modified carbon paste electrode was introduced. Timolol-imprinted polymers (MIP) were synthesized by the ultrasonic assisted suspension polymerization in silicon oil. The MIP nanoparticles were then embedded in a carbon paste (CP) electrode in order to prepare the nano-MIP-CP electrode. Timolol was extracted in the electrode for a definite time and then it was analyzed by square wave voltammetry, found to be an effective determination method...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28508306/multicenter-randomized-investigator-masked-study-comparing-brimonidine-tartrate-0-1-and-timolol-maleate-0-5-as-adjunctive-therapies-to-prostaglandin-analogues-in-normal-tension-glaucoma
#10
Shiro Mizoue, Koji Nitta, Motohiro Shirakashi, Akiyoshi Nitta, Shigeki Yamabayashi, Tairo Kimura, Toshihiko Ueda, Ryuji Takeda, Shun Matsumoto, Keiji Yoshikawa
INTRODUCTION: This study compared the efficacy and safety of adjunctive brimonidine tartrate 0.1% ophthalmic solution (brimonidine) and timolol maleate 0.5% ophthalmic solution (timolol) in prostaglandin analogue (PGA)-treated normal-tension glaucoma (NTG), assessing the non-inferiority of brimonidine in terms of intraocular pressure (IOP) reduction. METHODS: In this multicenter, randomized, investigator-masked, parallel-group, clinical study, adjunctive brimonidine or timolol was administered twice daily for 12 weeks in eyes with NTG that had been treated with PGA for at least 90 days and required additional treatment despite an IOP of 16 mmHg or less...
May 15, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28507428/propranolol-therapy-for-infantile-hemangioma-our-experience
#11
Ling Zhang, Hai-Wei Wu, Weien Yuan, Jia-Wei Zheng
OBJECTIVE: Hemangiomas are the most common benign vascular tumors of infancy. Although most infantile hemangiomas (IHs) have the ability to involute spontaneously after initial proliferation and resolve without consequence, intervention is required in a subset of IHs, which develop complications resulting in ulceration, bleeding, or aesthetic deformity. The primary treatment for this subset of IHs is pharmacological intervention, and propranolol has become the new first-line treatment for complicated hemangiomas...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28506871/the-role-of-hyaluronan-as-a-drug-carrier-to-enhance-the-bioavailability-of-extended-release-ophthalmic-formulations-hyaluronan-timolol-ionic-complexes-as-a-model-case
#12
F D Battistini, L I Tártara, C Boiero, M L Guzmán, L C Luciani-Giaccobbe, S D Palma, D A Allemandi, R H Manzo, M E Olivera
The aim of this work was to obtain information concerning the properties of ophthalmic formulations based on hyaluronic-drug ionic complexes, to identify the factors that determine the onset, intensity and duration of the pharmacotherapeutic effect. Dispersions of a complex of 0.5% w/v of sodium hyaluronate (HyNa) loaded with 0.5% w/v of timolol maleate (TM) were obtained and presented a counterionic condensation higher than 75%. For comparison a similar complex obtained with hyaluronic acid (HyH) was also prepared...
May 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28496310/patient-satisfaction-with-fixed-combination-bimatoprost-timolol-ophthalmic-solution-a-survey-study-in-patients-with-glaucoma-in-china
#13
Xinghuai Sun, Mingkai Lin, Xuanchu Duan, Chun Zhang, Jian Ming
BACKGROUND: Poor adherence to treatment is a problem in glaucoma, and patient dissatisfaction with topical glaucoma medication is a barrier to adherence. The objective of this study was to evaluate glaucoma patients' satisfaction with fixed-combination bimatoprost/timolol ophthalmic solution (BTFC). METHODS: This observational, multicenter study was conducted in China in adults with glaucoma treated with BTFC for 1-3 months. Five hundred patients answered a questionnaire concerning their demographic characteristics, history of glaucoma and topical glaucoma treatment, and use of BTFC...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28476050/influence-of-pilocarpine-and-timolol-on-human-meibomian-gland-epithelial-cells
#14
Yi Zhang, Wendy R Kam, Yang Liu, Xiaomin Chen, David A Sullivan
PURPOSE: Investigators have discovered that topical antiglaucoma drugs may induce meibomian gland dysfunction. This response may contribute to the dry eye disease commonly found in patients with glaucoma taking such medications. We hypothesize that drug action involves a direct effect on human meibomian gland epithelial cells (HMGECs). To test this hypothesis, we examined the influence of the antiglaucoma drugs, pilocarpine and timolol, on the morphology, survival, proliferation, and differentiation of HMGECs...
June 2017: Cornea
https://www.readbyqxmd.com/read/28470857/effects-of-0-2-brimonidine-and-0-2-brimonidine-0-5-timolol-on-intraocular-pressure-and-pupil-size-in-normal-equine-eyes
#15
M Von Zup, M Lassaline, P H Kass, P E Miller, S M Thomasy
BACKGROUND: Brimonidine is an α2 -adrenergic agonist that decreases aqueous humour production and may increase uveoscleral outflow. It has not been evaluated in normal or glaucomatous equine eyes. OBJECTIVES: To evaluate the efficacy and safety of brimonidine in lowering intraocular pressure (IOP), alone and in conjunction with timolol, as a treatment for equine glaucoma by comparing IOP in normal equine eyes treated with brimonidine and brimonidine-timolol, respectively, with IOP in control eyes...
May 4, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28458511/prospective-non-interventional-multicenter-study-of-the-intraocular-pressure-lowering-effects-of-prostaglandin-analog-prostamide-containing-therapies-in-previously-treated-patients-with-open-angle-glaucoma-or-ocular-hypertension
#16
Nevbahar Tamçelik, Belgin Izgi, Ahmet Temel, Nilgun Yildirim, Mehmet Okka, Altan Özcan, Nurşen Yüksel, Ufuk Elgin, Çiğdem Altan, Baris Ozer
OBJECTIVE: The objective of this study was to assess the intraocular pressure (IOP)-lowering efficacy, tolerability, safety, and usage patterns of prostaglandin analog/prostamide (PGA/P)-containing topical ocular hypotensives in ocular hypertension (OHT) and primary open-angle glaucoma in the Turkish clinical setting. METHODS: This non-interventional, multicenter study enrolled previously treated patients who failed to achieve target IOP (or experienced unacceptable adverse events [AEs]) and were prescribed a PGA/P-containing IOP-lowering agent...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28445315/the-effect-of-timolol-0-5-on-the-correction-of-myopic-regression-after-lasik
#17
RANDOMIZED CONTROLLED TRIAL
Hong Qi, Caifeng Gao, Yaxin Li, Xue Feng, Miao Wang, Yu Zhang, Yueguo Chen
BACKGROUD: Postlaser in situ keratomileusis (post-LASIK) refractive regression is defined as the gradual, partial, or total loss of initial correction that limits the predictability, efficiency, and long-term stability of LASIK. Our study assesses the effect of Timolol 0.5% on the correction of myopic regression after LASIK. METHODS: This prospective, randomized, controlled study included 62 eyes of 62 patients with myopic regression of -1.18 ± 0.86 diopters (D) after myopic LASIK...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28441214/the-osteo-odonto-keratoprosthesis
#18
REVIEW
Mehran Zarei-Ghanavati, Venkata Avadhanam, Alfonso Vasquez Perez, Christopher Liu
PURPOSE OF REVIEW: To describe the practice of and recent developments in the osteo-odonto-keratoprosthesis. RECENT FINDINGS: Formal psychological assessment and support have been described. A sub-aqua system for fashioning the osteo-odonto-keratoprosthesis lamina; adoption of thicker laminae; use of bisphosphonate drugs; advances in laminar imaging; and use of bone augmentation and bone morphogenetic protein have been described for prevention, detection, and management of laminar resorption...
July 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28433253/neuropeptide-s-increases-motor-activity-and-thermogenesis-in-the-rat-through-sympathetic-activation
#19
Takuya Ensho, Keiko Nakahara, Yoshihiro Suzuki, Noboru Murakami
The central role of neuropeptide S (NPS), identified as the endogenous ligand for GPR154, now named neuropeptide S receptor (NPSR), has not yet been fully clarified. We examined the central role of NPS for body temperature, energy expenditure, locomotor activity and adrenal hormone secretion in rats. Intracerebroventricular (icv) injection of NPS increased body temperature in a dose-dependent manner. Energy consumption and locomotor activity were also significantly increased by icv injection of NPS. In addition, icv injection of NPS increased the peripheral blood concentration of adrenalin and corticosterone...
April 13, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28429294/ocular-cubosome-drug-delivery-system-for-timolol-maleate-preparation-characterization-cytotoxicity-ex-vivo-and-in-vivo-evaluation
#20
Jiayuan Huang, Tingting Peng, Yanrong Li, Zhengwen Zhan, Youmei Zeng, Ying Huang, Xin Pan, Chuan-Yu Wu, Chuanbin Wu
Glaucoma is an ocular disease featuring increased intraocular pressure (IOP) and its primary treatment strategy is to lower IOP by medication. Current ocular drug delivery in treating glaucoma is confronting a variety of challenges, such as low corneal permeability and bioavailability due to the unique anatomical structure of the human eye. To tackle these challenges, a cubosome drug delivery system for glaucoma treatment was constructed for timolol maleate (TM) in this study. The TM cubosomes (liquid crystalline nanoparticles) were prepared using glycerol monooleate and poloxamer 407 via high-pressure homogenization...
April 20, 2017: AAPS PharmSciTech
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