keyword
MENU ▼
Read by QxMD icon Read
search

Timolol

keyword
https://www.readbyqxmd.com/read/28532033/synthesis-of-nano-sized-timolol-imprinted-polymer-via-ultrasonication-assisted-suspension-polymerization-in-silicon-oil-and-its-use-for-the-fabrication-of-timolol-voltammetric-sensor
#1
Taher Alizadeh, Mohammad Reza Ganjali, Faride Rafiei, Maedeh Akhoundian
A novel timolol voltammetric sensor based on the nano-sized molecularly imprinted polymer (nano-MIP)-modified carbon paste electrode was introduced. Timolol-imprinted polymers (MIP) were synthesized by the ultrasonic assisted suspension polymerization in silicon oil. The MIP nanoparticles were then embedded in a carbon paste (CP) electrode in order to prepare the nano-MIP-CP electrode. Timolol was extracted in the electrode for a definite time and then it was analyzed by square wave voltammetry, found to be an effective determination method...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28508306/multicenter-randomized-investigator-masked-study-comparing-brimonidine-tartrate-0-1-and-timolol-maleate-0-5-as-adjunctive-therapies-to-prostaglandin-analogues-in-normal-tension-glaucoma
#2
Shiro Mizoue, Koji Nitta, Motohiro Shirakashi, Akiyoshi Nitta, Shigeki Yamabayashi, Tairo Kimura, Toshihiko Ueda, Ryuji Takeda, Shun Matsumoto, Keiji Yoshikawa
INTRODUCTION: This study compared the efficacy and safety of adjunctive brimonidine tartrate 0.1% ophthalmic solution (brimonidine) and timolol maleate 0.5% ophthalmic solution (timolol) in prostaglandin analogue (PGA)-treated normal-tension glaucoma (NTG), assessing the non-inferiority of brimonidine in terms of intraocular pressure (IOP) reduction. METHODS: In this multicenter, randomized, investigator-masked, parallel-group, clinical study, adjunctive brimonidine or timolol was administered twice daily for 12 weeks in eyes with NTG that had been treated with PGA for at least 90 days and required additional treatment despite an IOP of 16 mmHg or less...
May 15, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28507428/propranolol-therapy-for-infantile-hemangioma-our-experience
#3
Ling Zhang, Hai-Wei Wu, Weien Yuan, Jia-Wei Zheng
OBJECTIVE: Hemangiomas are the most common benign vascular tumors of infancy. Although most infantile hemangiomas (IHs) have the ability to involute spontaneously after initial proliferation and resolve without consequence, intervention is required in a subset of IHs, which develop complications resulting in ulceration, bleeding, or aesthetic deformity. The primary treatment for this subset of IHs is pharmacological intervention, and propranolol has become the new first-line treatment for complicated hemangiomas...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28506871/the-role-of-hyaluronan-as-a-drug-carrier-to-enhance-the-bioavailability-of-extended-release-ophthalmic-formulations-hyaluronan-timolol-ionic-complexes-as-a-model-case
#4
F D Battistini, L I Tártara, C Boiero, M L Guzmán, L C Luciani-Giaccobbe, S D Palma, D A Allemandi, R H Manzo, M E Olivera
The aim of this work was to obtain information concerning the properties of ophthalmic formulations based on hyaluronic-drug ionic complexes, to identify the factors that determine the onset, intensity and duration of the pharmacotherapeutic effect. Dispersions of a complex of 0.5% w/v of sodium hyaluronate (HyNa) loaded with 0.5% w/v of timolol maleate (TM) were obtained and presented a counterionic condensation higher than 75%. For comparison a similar complex obtained with hyaluronic acid (HyH) was also prepared...
May 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28496310/patient-satisfaction-with-fixed-combination-bimatoprost-timolol-ophthalmic-solution-a-survey-study-in-patients-with-glaucoma-in-china
#5
Xinghuai Sun, Mingkai Lin, Xuanchu Duan, Chun Zhang, Jian Ming
BACKGROUND: Poor adherence to treatment is a problem in glaucoma, and patient dissatisfaction with topical glaucoma medication is a barrier to adherence. The objective of this study was to evaluate glaucoma patients' satisfaction with fixed-combination bimatoprost/timolol ophthalmic solution (BTFC). METHODS: This observational, multicenter study was conducted in China in adults with glaucoma treated with BTFC for 1-3 months. Five hundred patients answered a questionnaire concerning their demographic characteristics, history of glaucoma and topical glaucoma treatment, and use of BTFC...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28476050/influence-of-pilocarpine-and-timolol-on-human-meibomian-gland-epithelial-cells
#6
Yi Zhang, Wendy R Kam, Yang Liu, Xiaomin Chen, David A Sullivan
PURPOSE: Investigators have discovered that topical antiglaucoma drugs may induce meibomian gland dysfunction. This response may contribute to the dry eye disease commonly found in patients with glaucoma taking such medications. We hypothesize that drug action involves a direct effect on human meibomian gland epithelial cells (HMGECs). To test this hypothesis, we examined the influence of the antiglaucoma drugs, pilocarpine and timolol, on the morphology, survival, proliferation, and differentiation of HMGECs...
June 2017: Cornea
https://www.readbyqxmd.com/read/28470857/effect-of-0-2-brimonidine-and-0-2-0-5-brimonidine-timolol-on-intraocular-pressure-and-pupil-size-in-normal-equine-eyes
#7
M VonZup, M Lassaline, P H Kass, P E Miller, S M Thomasy
BACKGROUND: Brimonidine is an alpha 2-adrenergic agonist that decreases aqueous humor production and may increase uveoscleral outflow. It has not been evaluated in normal or glaucomatous equine eyes. OBJECTIVES: To evaluate the IOP-lowering efficacy and safety of brimonidine, alone and in conjunction with timolol, as a treatment for equine glaucoma by comparing IOP in normal equine eyes treated with brimonidine and brimonidine-timolol to control eyes. STUDY DESIGN: A balanced crossover design with 16 horses receiving one of two treatments, brimonidine and brimonidine-timolol, during each of two 10-day study phases, was used...
May 4, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28458511/prospective-non-interventional-multicenter-study-of-the-intraocular-pressure-lowering-effects-of-prostaglandin-analog-prostamide-containing-therapies-in-previously-treated-patients-with-open-angle-glaucoma-or-ocular-hypertension
#8
Nevbahar Tamçelik, Belgin Izgi, Ahmet Temel, Nilgun Yildirim, Mehmet Okka, Altan Özcan, Nurşen Yüksel, Ufuk Elgin, Çiğdem Altan, Baris Ozer
OBJECTIVE: The objective of this study was to assess the intraocular pressure (IOP)-lowering efficacy, tolerability, safety, and usage patterns of prostaglandin analog/prostamide (PGA/P)-containing topical ocular hypotensives in ocular hypertension (OHT) and primary open-angle glaucoma in the Turkish clinical setting. METHODS: This non-interventional, multicenter study enrolled previously treated patients who failed to achieve target IOP (or experienced unacceptable adverse events [AEs]) and were prescribed a PGA/P-containing IOP-lowering agent...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28445315/the-effect-of-timolol-0-5-on-the-correction-of-myopic-regression-after-lasik
#9
Hong Qi, Caifeng Gao, Yaxin Li, Xue Feng, Miao Wang, Yu Zhang, Yueguo Chen
BACKGROUD: Postlaser in situ keratomileusis (post-LASIK) refractive regression is defined as the gradual, partial, or total loss of initial correction that limits the predictability, efficiency, and long-term stability of LASIK. Our study assesses the effect of Timolol 0.5% on the correction of myopic regression after LASIK. METHODS: This prospective, randomized, controlled study included 62 eyes of 62 patients with myopic regression of -1.18 ± 0.86 diopters (D) after myopic LASIK...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28441214/the-osteo-odonto-keratoprosthesis
#10
Mehran Zarei-Ghanavati, Venkata Avadhanam, Alfonso Vasquez Perez, Christopher Liu
PURPOSE OF REVIEW: To describe the practice of and recent developments in the osteo-odonto-keratoprosthesis. RECENT FINDINGS: Formal psychological assessment and support have been described. A sub-aqua system for fashioning the osteo-odonto-keratoprosthesis lamina; adoption of thicker laminae; use of bisphosphonate drugs; advances in laminar imaging; and use of bone augmentation and bone morphogenetic protein have been described for prevention, detection, and management of laminar resorption...
April 24, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28433253/neuropeptide-s-increases-motor-activity-and-thermogenesis-in-the-rat-through-sympathetic-activation
#11
Takuya Ensho, Keiko Nakahara, Yoshihiro Suzuki, Noboru Murakami
The central role of neuropeptide S (NPS), identified as the endogenous ligand for GPR154, now named neuropeptide S receptor (NPSR), has not yet been fully clarified. We examined the central role of NPS for body temperature, energy expenditure, locomotor activity and adrenal hormone secretion in rats. Intracerebroventricular (icv) injection of NPS increased body temperature in a dose-dependent manner. Energy consumption and locomotor activity were also significantly increased by icv injection of NPS. In addition, icv injection of NPS increased the peripheral blood concentration of adrenalin and corticosterone...
April 13, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28429294/ocular-cubosome-drug-delivery-system-for-timolol-maleate-preparation-characterization-cytotoxicity-ex-vivo-and-in-vivo-evaluation
#12
Jiayuan Huang, Tingting Peng, Yanrong Li, Zhengwen Zhan, Youmei Zeng, Ying Huang, Xin Pan, Chuan-Yu Wu, Chuanbin Wu
Glaucoma is an ocular disease featuring increased intraocular pressure (IOP) and its primary treatment strategy is to lower IOP by medication. Current ocular drug delivery in treating glaucoma is confronting a variety of challenges, such as low corneal permeability and bioavailability due to the unique anatomical structure of the human eye. To tackle these challenges, a cubosome drug delivery system for glaucoma treatment was constructed for timolol maleate (TM) in this study. The TM cubosomes (liquid crystalline nanoparticles) were prepared using glycerol monooleate and poloxamer 407 via high-pressure homogenization...
April 20, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28421234/the-role-of-topical-timolol-in-the-treatment-of-infantile-heman-giomas-a-systematic-review-and-meta-analysis
#13
Maham Khan, Aaron Boyce, David Prieto-Merino, Åke Svensson, Emma Wedgeworth, Carsten Flohr
To date the efficacy and safety of topical timolol in the treatment of infantile hemangioma has not be reviewed and analysed systematically. We collated all published data on the efficacy and safety of topical timolol in the treatment of infantile hemangioma. A total of 31 studies with 691 patients were included. The fixed effects pooled estimate of the response rate defined as any improvement from baseline of infantile hemangioma after treatment with topical timolol was significant (RR = 8.96; 95% CI 5...
April 19, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28411778/lack-of-efficacy-of-topical-timolol-for-cutaneous-telangiectasias-in-patients-with-hereditary-hemorrhagic-telangiectasia-results-of-a-pilot-study
#14
Hana Jeon, Bernard Cohen
No abstract text is available yet for this article.
May 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28408797/ocular-hypotensive-effects-of-a-rho-associated-protein-kinase-inhibitor-in-rabbits
#15
Muhammad Irfan Kamaruddin, Momoko Nakamura-Shibasaki, Yu Mizuno, Yoshiaki Kiuchi
PURPOSE: Ripasudil is a novel Rho-associated protein kinase inhibitor that is used to treat ocular hypertension. However, the comparison of the intraocular pressure (IOP)-lowering effects between ripasudil alone and other ocular hypotensive drugs has not been studied thoroughly. The purpose of this study is to examine the ocular hypotensive effects of 0.4% ripasudil, 2% pilocarpine, 0.5% timolol and 0.1% dorzolamide in rabbits. We also studied the IOP changes when 0.4% ripasudil was combined with 2% pilocarpine, 0...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28399267/development-of-a-%C3%AE-9-tetrahydrocannabinol-amino-acid-dicarboxylate-prodrug-with-improved-ocular-bioavailability
#16
Goutham R Adelli, Prakash Bhagav, Pranjal Taskar, Tushar Hingorani, Sara Pettaway, Waseem Gul, Mahmoud A ElSohly, Michael A Repka, Soumyajit Majumdar
Purpose: The aim of the present study was to evaluate the utility of the relatively hydrophilic Δ9-tetrahydrocannabinol (THC) prodrugs, mono and di-valine esters (THC-Val and THC-Val-Val) and the amino acid (valine)-dicarboxylic acid (hemisuccinate) ester (THC-Val-HS), with respect to ocular penetration and intraocular pressure (IOP) lowering activity. THC, timolol, and pilocarpine eye drops were used as controls. Methods: THC-Val, THC-Val-Val, and THC-Val-HS were synthesized and chemically characterized...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28379653/factors-related-to-prostaglandin-associated-periorbitopathy-in-glaucoma-patients
#17
Chanikarn Patradul, Visanee Tantisevi, Anita Manassakorn
PURPOSE: To determine factors related to prostaglandin-associated periorbitopathy (PAP) and its prevalence in glaucoma or ocular hypertension (OHT) patients using prostaglandins analogs (PGAs). DESIGN: A cross-sectional study. METHODS: A study of glaucoma or OHT patients, using topical PGAs for at least 3 months, was performed. Eyes treated with PGAs were photoraphed and independently evaluated for PAP by 2 glaucoma specialists using at least 4 out of 7 clinical appearances...
March 29, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28376651/evaluation-of-the-effects-on-choroidal-thickness-of-bimatoprost-0-03-versus-a-brinzolamide-1-0-timolol-maleate-0-5-fixed-combination
#18
Nurettin Akyol, Ahmet Kalkisim, Adem Turk, Mehmet Kola, Halil Ibrahim Imamoglu
OBJECTIVE: To investigate the effects of two different medical treatment options on choroidal thickness (CT) in cases of open-angle glaucoma (OAG). METHODS: 67 eyes newly diagnosed with OAG and 52 healthy eyes constituting the control group were included in the study. Glaucomatous eyes were randomly divided into two subgroups; Group I was started on bimatoprost 0.03% and Group II on a brinzolamide 1.0%/timolol maleate 0.5% fixed combination (BTFC). Intraocular pressure (IOP), ocular pulse amplitude (OPA), and subfoveal CT measurements were performed in all eyes in the study before treatment and on weeks 2, 4 and 8 after treatment...
April 4, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28371482/additive-effects-and-safety-of-fixed-combination-therapy-with-1-brinzolamide-and-0-5-timolol-versus-1-dorzolamide-and-0-5-timolol-in-prostaglandin-treated-glaucoma-patients
#19
Makoto Aihara, Misato Adachi, Hiroshi Matsuo, Tetsuya Togano, Takeo Fukuchi, Noriyuki Sasaki
PURPOSE: To compare the additive effects and safety of 1% brinzolamide/0.5% timolol fixed combination (BTFC) versus the low-dose regimen of 1% dorzolamide/0.5% timolol fixed combination (DTFC) in patients with open-angle glaucoma and ocular hypertension (OAG/OH) following treatment with prostaglandin analogues (PGAs). METHODS: A prospective, randomized, double-masked, multicentre, parallel-group and active-controlled study included 201 Japanese OAG/OH patients who had been treated with PGA...
April 3, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28369943/spectral-doppler-ultrasound-for-predicting-long-term-response-to-topical-timolol-in-children-with-infantile-hemangioma
#20
Lili He, Guoying Huang
BACKGROUND: To assess the utility of color and spectral Doppler ultrasound at predicting infantile hemangioma (IH) response to timolol. METHODS: Eighty-three children (0-6 months old) with IH were treated with topical 0.5% timolol maleate twice daily for 6 months. They underwent color and spectral Doppler sonographic examinations at the first visit and 1 month after beginning timolol. Hemangioma volume, arterial diameter (AD), venous diameter (VD), resistance index (RI), pulsatility index (PI), peak arterial systolic velocity (PASV), maximum venous velocity, and mean venous velocity were measured...
March 31, 2017: Journal of Clinical Ultrasound: JCU
keyword
keyword
26347
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"