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Eyedrops effects

Weibao Xiao, Li Sun, Nan Zhang, Wen Ye
Fingolimod is a promising prodrug in attenuating multiple sclerosis and prolonging survival of organ allograft, with many other protective effects. Its mechanism of action is related to the internalization of sphingosine 1-phosphate receptors (S1PRs). Our previous study indicated that fingolimod eyedrop was efficacious in inhibiting ocular inflammation in a dry eye disease (DED) model of Non-Obese Diabetic (NOD) mice. In the current study, we evaluated potential adverse effects of fingolimod eyedrop. Inbred 10-week-old BALB/C mice were randomly divided into four groups, fingolimod-treated groups at three different concentrations (0...
November 26, 2016: Basic & Clinical Pharmacology & Toxicology
T Kalezic, I Vukovic, M Andjelkovic, M Gajic, J Potic, M Stojkovic
PURPOSE: Whether cycloplegics affect standard keratorefractometric and tomographic measurements is unknown. The purpose of our study was to compare the effects of cycloplegics (cyclopentolate and atropine) on corneal shape and refractive power of the eye. METHODS: This study was performed on 84 eyes of 49 study participants. Patients were randomized into two groups: atropine 1% (32 eyes) and cyclopentolate 1% (52 eyes). Corneal tomography was performed with the Orbscan IIz...
November 11, 2016: Journal Français D'ophtalmologie
Christophe Baudouin, David J Galarreta, Ewa Mrukwa-Kominek, Daniel Böhringer, Vincenzo Maurino, Michel Guillon, Gemma C M Rossi, Ivanka J Van der Meulen, Abayomi Ogundele, Marc Labetoulle
PURPOSE: To evaluate and compare the efficacy of a lipid-based lubricant eyedrop formulation (hydroxypropyl guar/propylene glycol/phospholipid [HPG/PG/PL]) with preservative-free saline for the treatment of dry eye. METHODS: This was a prospective, multicenter, randomized, single-masked, parallel-group phase 4 clinical study. Patients ≥18 years diagnosed with dry eye received 1 drop of saline 4 times daily (QID) for 15 days during a run-in phase, followed by randomization...
October 27, 2016: European Journal of Ophthalmology
N Venkatesh Prajna, Tiruvengada Krishnan, Revathi Rajaraman, Sushila Patel, Muthiah Srinivasan, Manoranjan Das, Kathryn J Ray, Kieran S O'Brien, Catherine E Oldenburg, Stephen D McLeod, Michael E Zegans, Travis C Porco, Nisha R Acharya, Thomas M Lietman, Jennifer Rose-Nussbaumer
Objective: To compare oral voriconazole with placebo in addition to topical antifungals in the treatment of filamentous fungal keratitis. Design, Setting, and Participants: The Mycotic Ulcer Treatment Trial II (MUTT II), a multicenter, double-masked, placebo-controlled, randomized clinical trial, was conducted in India and Nepal, with 2133 individuals screened for inclusion. Patients with smear-positive filamentous fungal ulcers and visual acuity of 20/400 (logMAR 1...
October 27, 2016: JAMA Ophthalmology
Ahmed M Bata, Katarzyna J Witkowska, Piotr A Wozniak, Klemens Fondi, Gerald Schmidinger, Niklas Pircher, Stephan Szegedi, Valentin Aranha Dos Santos, Anca Pantalon, René M Werkmeister, Gerhard Garhofer, Leopold Schmetterer, Doreen Schmidl
Importance: Corneal abrasions are frequent after standard (epithelium-off [epi-off]) corneal collagen cross-linking (CXL) in patients with progressive keratoconus. A new matrix therapy agent (ReGeneraTing Agent [RGTA]) has been developed to promote corneal wound healing. Objective: To assess the effect of the new type of matrix therapy agent on corneal wound healing after epi-off CXL in patients with keratoconus. Design, Setting, and Participants: This double-masked randomized clinical trial enrolled 40 patients with keratoconus undergoing epi-off CXL from July 18, 2014, to October 21, 2015, when the last follow-up was completed...
October 1, 2016: JAMA Ophthalmology
Anne-Laure Lux, Alice Degoumois, Amandine Barjol, Frédéric Mouriaux, Eric Denion
PURPOSE: Comparison of the efficacy of tropicamide eyedrops to the combination of 0.5% tropicamide and 5% phenylephrine eyedrops in order to achieve a proper dilation in premature infants undergoing screening for retinopathy of prematurity. METHODS: A prospective, randomized, double-blind study was conducted to compare the efficacy of two mydriatic regimens: one regimen consisting of three drops of 0.5% tropicamide (TTT regimen), the other regimen consisting of one drop of 5% phenylephrine and two drops of 0...
August 13, 2016: Acta Ophthalmologica
Giuseppe Giannaccare, Michela Fresina, Alberto Pazzaglia, Piera Versura
Graft rejection is the most significant complication corneal transplantation and the leading indication for overall corneal transplantation. Corticosteroid therapy represents the mainstay of graft rejection treatment; however, the optimal route of administration of corticosteroid remains uncertain. We report herein for the first time the multimodal imaging of a case of long-lasting corneal endothelial graft rejection successfully reversed 3 months after dexamethasone intravitreal implant. A 29-year-old Asian female presented with a long-lasting corneal endothelial graft rejection in her left phakic eye...
2016: International Medical Case Reports Journal
Frédéric Chiambaretta, Serge Doan, Marc Labetoulle, Nicolas Rocher, Lamia El Fekih, Riadh Messaoud, Moncef Khairallah, Christophe Baudouin
PURPOSE: This study compared the efficacy and safety of hyaluronic acid (HA)-trehalose, a new eyedrop containing trehalose (a natural bioprotectant) and HA, to an established formulation containing only HA. METHODS: This was a phase III, randomized, active-controlled, investigator-masked, multicenter study in France and Tunisia. In all, 105 adult patients (≥18 years) with moderate to severe dry eye disease (DED) received either HA-trehalose (n = 52) or HA (n = 53) 3-6 times per day for 84 days...
July 20, 2016: European Journal of Ophthalmology
Chia-Yi Lee, Chi-Chin Sun, Yi-Fang Lin, Ken-Kuo Lin
BACKGROUND: Myopia-related maculopathy is one of the leading causes of blindness in the world. The prevalence of myopia has been reported as high as 90 % in some Asian countries. Therefore, controlling myopia progression is an urgent public issue. The purpose of this study is to evaluate the effects of topical atropine with different concentrations on intraocular pressure measurements and myopia progression in school-aged children in Taiwan. METHODS: Fifty-six myopic children were divided into three groups: 32 children were treated with 0...
2016: BMC Ophthalmology
Jennifer A Ebeigbe, Chike Martin Emedike
PURPOSE: Most causes of childhood blindness are treatable or preventable. Knowledge of parents' awareness and perception of eye problems is important in helping to understand parents' eye care seeking behavior. This understanding becomes necessary as early detection and intervention can be effective when done at an early age. METHOD: Study was carried out in Benin City, Nigeria. Thirty-five parents aged 38-54 years with a mean age of 43(±2) years were recruited...
July 13, 2016: Journal of Optometry
Sangchul Yoon, Eun-Do Kim, Min-Suk Song, Soo Jung Han, Tae Kwann Park, Kyoung Sub Choi, Young-Ki Choi, Kyoung Yul Seo
We investigated eyedrop vaccination (EDV) in pre-clinical development for immunological protection against influenza and for potential side effects involving ocular inflammation and the central nervous system (CNS). Live attenuated influenza EDV, CA07 (H1N1), PZ-4 (H1N2) and Uruguay (H3N2), induced both systemic and mucosal virus-specific antibody responses in ferrets. In addition, EDV resulted in a clinically significant protection against viral challenge, and suppression of viral replication in nasal secretion and lung tissue...
2016: PloS One
Jieting She, Guoming Zhang, Jian Zeng, Yi Chen, Xuyang Liu, Hongbo Cheng
OBJECTIVE: To evaluate the effects of intravitreal injection of sterile air followed by scleral cryotherapy on simple rhegmatogenous retinal detachment (RRD). METHODS: Retrospective study. Thirty-five cases (thirty-five eyes) with RRD were collected from Oct 2013 to Mar 2014. Among them, macular detachment was observed in 31cases, all accompanied with obvious synchesis. All retinal breaks were horseshoe shaped and holes located above 9 o'clock to 3 o'clock position, with size ranged from 0...
May 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Wendy Chan, Alina Akhbanbetova, Andrew J Quantock, Charles M Heard
The application of inhibitors of the Rho kinase pathway (ROCK inhibitors) to the surface of the eye in the form of eyedrops has beneficial effects which aid the recovery of diseased or injured endothelial cells that line the inner surface of the cornea. The aim of this study was to test the plausibility of delivering a selective ROCK inhibitor, Y-27632, to the cornea using a thin polymeric film. Mucoadhesive polymeric thin films were prepared incorporating Y-27632 and diffusional release into PBS was determined...
August 25, 2016: European Journal of Pharmaceutical Sciences
I Bravo-Osuna, M Vicario-de-la-Torre, V Andrés-Guerrero, J Sánchez-Nieves, M Guzmán-Navarro, F J de la Mata, R Gómez, B de Las Heras, P Argüeso, G Ponchel, R Herrero-Vanrell, I T Molina-Martínez
The purpose of this research was to determine the potential use of water-soluble anionic and cationic carbosilane dendrimers (generations 1-3) as mucoadhesive polymers in eyedrop formulations. Cationic carbosilane dendrimers decorated with ammonium -NH3(+) groups were prepared by hydrosylilation of Boc-protected allylamine and followed by deprotection with HCl. Anionic carbosilane dendrimers with terminal carboxylate groups were also employed in this study. In vitro and in vivo tolerance studies were performed in human ocular epithelial cell lines and rabbit eyes respectively...
September 6, 2016: Molecular Pharmaceutics
Anthony J King, Alan P Rotchford
IMPORTANCE: Establishing the true therapeutic effect of eyedrops when initiating glaucoma therapy is important. Accurate prediction of the intraocular pressure (IOP)-lowering response in the fellow eye when using a monocular trial eliminates the need for additional office visits to confirm the therapeutic effect. OBJECTIVE: To investigate the validity of the monocular trial in patients commencing topical glaucoma treatment at different time points. DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study of untreated patients with open-angle glaucoma or ocular hypertension at a hospital-based glaucoma service among treatment-naive individuals...
July 1, 2016: JAMA Ophthalmology
Vishnu S Gupta, Harindersingh Sethi, Mayuresh Naik
PURPOSE: To elucidate compliance rates among glaucoma patients in a tertiary healthcare center, reasons for noncompliance and response-based-solutions to improve compl iance in the same cohort. MATERIALS AND METHODS: In the Glauco-Jung study, a cross-sectional descriptive epidemiological one, information was obtained from 500 patients from 1st January, 2014 to 30th June, 2014. Patients were intercepted at entry point where they get their intraocular pressure (IOP) checked, wherein they were asked to fill an exhaustive questionnaire...
May 2015: Journal of Current Glaucoma Practice
Masahiko Ayaki, Ikuko Toda, Naoko Tachi, Kazuno Negishi, Kazuo Tsubota
PURPOSE: Dry eye disease (DED) is potentially associated with sleep and mood disorders. This study evaluated sleep quality in patients with DED using a questionnaire-based survey before and after topical eyedrop treatment. The effectiveness of sleep and ophthalmic services in assisting with sleep problems in patients with eye disease was also assessed. METHODS: Seventy-one consecutive patients with DED visiting eight general eye clinics in various locations answered a questionnaire containing the Pittsburgh Sleep Quality Index and Hospital Anxiety and Depression Scale...
2016: Neuropsychiatric Disease and Treatment
Hsin Yu Yao, Ta Hsiung Cho, Ching Hsiang Lu, Feng Chi Lin, Chi Ting Horng
A 20-year-old male soldier was hit by the jellyfish. The ophthalmic examination revealed that epithelial keratitis and corneal oedema in the right eye. We prescribed 3% NaCl eyedrops and 0.3% Norfloxacin eyedrops in the treatment of the corneal jellyfish stings. Two weeks later, the cornea in the right eye healed. In this case report, 3% NaCl eyedrops was effective in the treatment of acute phase of jellyfish stings of the cornea.
February 2016: Journal of Travel Medicine
Anisa I Gire, Sezen Karakus, Shanna M Ingrodi, Esen Karamursel Akpek
PURPOSE: To study the systemic safety and patient tolerability of frequent dosing of cyclosporine A (CsA) 0.05% eyedrops in the treatment of ocular surface disease. This is a retrospective case series. Patients with significant ocular surface diseases who were treated using topical CsA higher than the usual twice daily dosing (3-8 times daily and over a treatment period of 1-70 months). The main outcome measures are plasma levels of CsA and local tolerability. METHODS: Symptom assessment, corneal staining using fluorescein, conjunctival staining using lissamine green, tear film breakup time, and other signs according to the disease process were monitored...
April 2016: Journal of Ocular Pharmacology and Therapeutics
Johanna Norderyd, Jonas Graf, Agneta Marcusson, Karolina Nilsson, Eva Sjöstrand, Gunilla Steinwall, Elinor Ärleskog, Mats Bågesund
BACKGROUND: Drooling can be a severe disability and have high impact on daily life. Reversible treatment is preferable. AIM: To analyse whether sublingual administration of atropine eyedrops is a useful reversible treatment option for severe drooling in children with disabilities. DESIGN: The study had a prospective, single-system research design. The participants served as their own controls. The study period was 3 weeks without treatment, 4 weeks with atropine eyedrop solution 10 mg/mL one drop a day followed by 4 weeks of one drop twice a day...
December 27, 2015: International Journal of Paediatric Dentistry
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