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Eyedrops effects

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https://www.readbyqxmd.com/read/28044424/ocular-nerve-growth-factor-administration-modulates-brain-derived-neurotrophic-factor-signaling-in-prefrontal-cortex-of-healthy-and-diabetic-rats
#1
Pamela Rosso, Sara De Nicolò, Valentina Carito, Marco Fiore, Angela Iannitelli, Sandra Moreno, Paola Tirassa
AIMS: Nerve growth factor (NGF) eyedrops (ed-NGF) activate brain neurons, stimulate growth factors, including brain-derived neurotrophic factor (BDNF), and exert neuroprotection in the forebrain of streptozotocin-induced diabetic rats (STZ rats). In this study, the effects of ed-NGF on BDNF signaling in the prefrontal cortex (PFC) were explored in healthy and STZ-diabetic rats, in which cortical neuronal and axonal loss, and altered circulating BDNF associated with depressive phenotype are also described...
January 3, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28009414/bromfenac-eyedrops-in-the-treatment-of-diabetic-macular-edema-a-pilot-study
#2
Antonio Pinna, Francesco Blasetti, Giuseppe D'Amico Ricci, Francesco Boscia
PURPOSE: To evaluate the efficacy and safety of topical bromfenac in patients with newly diagnosed diabetic macular edema (DME). METHODS: In this pilot study including 17 patients with monocular, newly diagnosed DME, diagnosis of DME was established by the detection of retinal thickening at or within 500 μm of the center of the macula on ophthalmoscopic examination, according to the Early Treatment Diabetic Retinopathy Study classification. Central macular thickness (CMT) was determined by optical coherence tomography...
November 16, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/27941330/hyperosmolarity-and-benzalkonium-chloride-differently-stimulate-inflammatory-markers-in-conjunctiva-derived-epithelial-cells-in-vitro
#3
Elise Warcoin, Chloé Clouzeau, Christophe Roubeix, Anne-Laure Raveu, David Godefroy, Luisa Riancho, Christophe Baudouin, Françoise Brignole-Baudouin
Tear hyperosmolarity is known to cause ocular surface inflammation in dry eye syndrome. Benzalkonium chloride (BAK), an eyedrop preservative, is known to induce dry eye in long-term-treated patients. Analyzing the modulation of the proinflammatory potential of hyperosmolarity in the presence of BAK on the conjunctiva could give new insights into the effect of this preservative on the disease. In a hyperosmolar model on a conjunctiva-derived cell line, and in the presence of BAK, we evaluated key inflammatory markers [CCL2, IL-8, IL-6, macrophage migration inhibitory factor (MIF) and intercellular adhesion molecule (ICAM)-1] as well as the osmoprotectant element nuclear factor of activated T cells (NFAT)5 using ELISA, RT-qPCR or immunofluorescence staining...
December 10, 2016: Ophthalmic Research
https://www.readbyqxmd.com/read/27932860/rebound-macular-edema-following-oral-acetazolamide-therapy-for-juvenile-x-linked-retinoschisis-in-an-italian-family
#4
Maria Silvana Galantuomo, Maurizio Fossarello, Alberto Cuccu, Roberta Farci, Markus N Preising, Birgit Lorenz, Pietro Emanuele Napoli
BACKGROUND: Juvenile X-linked retinoschisis (RS1, OMIM: 312700) is a hereditary vitreoretinal dystrophy characterized by bilateral foveal schisis and, in half of the patients, splitting through the nerve fiber layer in the peripheral retina. In the first decade of life, patients usually develop a decrease in visual acuity. Long-term visual outcomes can be poor due to the limited number of known successful treatments. PURPOSE: The purposes of this study were to present, for the first time, a p...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27930371/effect-of-low-concentration-nonmydriatic-selective-alpha-adrenergic-agonist-eyedrops-on-upper-eyelid-position
#5
Taís B Mendonça, Atauíne P Lummertz, Francisco J L Bocaccio, Fernando Procianoy
BACKGROUND: Ptosis after botulinum toxin injection is a disturbing complication. Decongestant and antiglaucoma eyedrops are frequently prescribed for temporary improvement of eyelid ptosis. Although frequently cited on informal communications, the effect of these drugs on eyelid position has never been compared in a formal study. OBJECTIVE: To measure the effect of low-concentration, nonmydriatic selective alpha agonist eyedrops on upper eyelid position. METHODS AND MATERIALS: This nonrandomized clinical trial enrolled 20 healthy subjects aged 18 to 50 years...
December 2, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27918829/identification-of-novel-endogenous-anti-lymph-angiogenic-factors-in-the-aqueous-humor
#6
Felix Bock, Jasmine Onderka, Gabriele Braun, Ann-Charlott Schneider, Deniz Hos, Yanlong Bi, Björn O Bachmann, Claus Cursiefen
Purpose: The avascular cornea is in direct contact with aqueous humor (AqH). Here we investigate whether AqH exerts anti(lymph)angiogenic effects and thereby may contribute to corneal (lymph)angiogenic privilege. Methods: Using the murine model of suture-induced inflammatory corneal hem- and lymphangiogenesis, the potential anti(lymph)angiogenic effect of AqH was analyzed by applying murine AqH as eyedrops. Anti(lymph)angiogenic effects were measured using morphometric analysis of flat mounts stained with CD31 as panendothelial and LYVE-1 as specific lymphatic endothelial marker...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27888572/adverse-effect-profile-of-topical-ocular-administration-of-fingolimod-for-treatment-of-dry-eye-disease
#7
Weibao Xiao, Li Sun, Nan Zhang, Wen Ye
Fingolimod is a promising prodrug in attenuating multiple sclerosis and prolonging survival of organ allograft, with many other protective effects. Its mechanism of action is related to the internalization of sphingosine 1-phosphate receptors (S1PRs). Our previous study indicated that fingolimod eyedrop was efficacious in inhibiting ocular inflammation in a dry eye disease (DED) model of Non-Obese Diabetic (NOD) mice. In the current study, we evaluated potential adverse effects of fingolimod eyedrop. Inbred 10-week-old BALB/C mice were randomly divided into four groups, fingolimod-treated groups at three different concentrations (0...
November 26, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27843084/-the-effects-of-cycloplegic-eyedrops-on-corneal-tomography
#8
T Kalezic, I Vukovic, M Andjelkovic, M Gajic, J Potic, M Stojkovic
PURPOSE: Whether cycloplegics affect standard keratorefractometric and tomographic measurements is unknown. The purpose of our study was to compare the effects of cycloplegics (cyclopentolate and atropine) on corneal shape and refractive power of the eye. METHODS: This study was performed on 84 eyes of 49 study participants. Patients were randomized into two groups: atropine 1% (32 eyes) and cyclopentolate 1% (52 eyes). Corneal tomography was performed with the Orbscan IIz...
December 2016: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/27791253/clinical-evaluation-of-an-oil-based-lubricant-eyedrop-in-dry-eye-patients-with-lipid-deficiency
#9
Christophe Baudouin, David J Galarreta, Ewa Mrukwa-Kominek, Daniel Böhringer, Vincenzo Maurino, Michel Guillon, Gemma C M Rossi, Ivanka J Van der Meulen, Abayomi Ogundele, Marc Labetoulle
PURPOSE: To evaluate and compare the efficacy of a lipid-based lubricant eyedrop formulation (hydroxypropyl guar/propylene glycol/phospholipid [HPG/PG/PL]) with preservative-free saline for the treatment of dry eye. METHODS: This was a prospective, multicenter, randomized, single-masked, parallel-group phase 4 clinical study. Patients ≥18 years diagnosed with dry eye received 1 drop of saline 4 times daily (QID) for 15 days during a run-in phase, followed by randomization...
October 27, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/27787540/effect-of-oral-voriconazole-on-fungal-keratitis-in-the-mycotic-ulcer-treatment-trial-ii-mutt-ii-a-randomized-clinical-trial
#10
N Venkatesh Prajna, Tiruvengada Krishnan, Revathi Rajaraman, Sushila Patel, Muthiah Srinivasan, Manoranjan Das, Kathryn J Ray, Kieran S O'Brien, Catherine E Oldenburg, Stephen D McLeod, Michael E Zegans, Travis C Porco, Nisha R Acharya, Thomas M Lietman, Jennifer Rose-Nussbaumer
Objective: To compare oral voriconazole with placebo in addition to topical antifungals in the treatment of filamentous fungal keratitis. Design, Setting, and Participants: The Mycotic Ulcer Treatment Trial II (MUTT II), a multicenter, double-masked, placebo-controlled, randomized clinical trial, was conducted in India and Nepal, with 2133 individuals screened for inclusion. Patients with smear-positive filamentous fungal ulcers and visual acuity of 20/400 (logMAR 1...
December 1, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27584715/effect-of-a-matrix-therapy-agent-on-corneal-epithelial-healing-after-standard-collagen-cross-linking-in-patients-with-keratoconus-a-randomized-clinical-trial
#11
Ahmed M Bata, Katarzyna J Witkowska, Piotr A Wozniak, Klemens Fondi, Gerald Schmidinger, Niklas Pircher, Stephan Szegedi, Valentin Aranha Dos Santos, Anca Pantalon, René M Werkmeister, Gerhard Garhofer, Leopold Schmetterer, Doreen Schmidl
Importance: Corneal abrasions are frequent after standard (epithelium-off [epi-off]) corneal collagen cross-linking (CXL) in patients with progressive keratoconus. A new matrix therapy agent (ReGeneraTing Agent [RGTA]) has been developed to promote corneal wound healing. Objective: To assess the effect of the new type of matrix therapy agent on corneal wound healing after epi-off CXL in patients with keratoconus. Design, Setting, and Participants: This double-masked randomized clinical trial enrolled 40 patients with keratoconus undergoing epi-off CXL from July 18, 2014, to October 21, 2015, when the last follow-up was completed...
October 1, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27519933/combination-of-5-phenylephrine-and-0-5-tropicamide-eyedrops-for-pupil-dilation-in-neonates-is-twice-as-effective-as-0-5-tropicamide-eyedrops-alone
#12
Anne-Laure Lux, Alice Degoumois, Amandine Barjol, Frédéric Mouriaux, Eric Denion
PURPOSE: Comparison of the efficacy of tropicamide eyedrops to the combination of 0.5% tropicamide and 5% phenylephrine eyedrops in order to achieve a proper dilation in premature infants undergoing screening for retinopathy of prematurity. METHODS: A prospective, randomized, double-blind study was conducted to compare the efficacy of two mydriatic regimens: one regimen consisting of three drops of 0.5% tropicamide (TTT regimen), the other regimen consisting of one drop of 5% phenylephrine and two drops of 0...
August 13, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27468251/long-lasting-corneal-endothelial-graft-rejection-successfully-reversed-after-dexamethasone-intravitreal-implant
#13
Giuseppe Giannaccare, Michela Fresina, Alberto Pazzaglia, Piera Versura
Graft rejection is the most significant complication corneal transplantation and the leading indication for overall corneal transplantation. Corticosteroid therapy represents the mainstay of graft rejection treatment; however, the optimal route of administration of corticosteroid remains uncertain. We report herein for the first time the multimodal imaging of a case of long-lasting corneal endothelial graft rejection successfully reversed 3 months after dexamethasone intravitreal implant. A 29-year-old Asian female presented with a long-lasting corneal endothelial graft rejection in her left phakic eye...
2016: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/27445067/a-randomized-controlled-study-of-the-efficacy-and-safety-of-a-new-eyedrop-formulation-for-moderate-to-severe-dry-eye-syndrome
#14
Frédéric Chiambaretta, Serge Doan, Marc Labetoulle, Nicolas Rocher, Lamia El Fekih, Riadh Messaoud, Moncef Khairallah, Christophe Baudouin
PURPOSE: This study compared the efficacy and safety of hyaluronic acid (HA)-trehalose, a new eyedrop containing trehalose (a natural bioprotectant) and HA, to an established formulation containing only HA. METHODS: This was a phase III, randomized, active-controlled, investigator-masked, multicenter study in France and Tunisia. In all, 105 adult patients (≥18 years) with moderate to severe dry eye disease (DED) received either HA-trehalose (n = 52) or HA (n = 53) 3-6 times per day for 84 days...
July 20, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/27435576/effects-of-topical-atropine-on-intraocular-pressure-and-myopia-progression-a-prospective-comparative-study
#15
Chia-Yi Lee, Chi-Chin Sun, Yi-Fang Lin, Ken-Kuo Lin
BACKGROUND: Myopia-related maculopathy is one of the leading causes of blindness in the world. The prevalence of myopia has been reported as high as 90 % in some Asian countries. Therefore, controlling myopia progression is an urgent public issue. The purpose of this study is to evaluate the effects of topical atropine with different concentrations on intraocular pressure measurements and myopia progression in school-aged children in Taiwan. METHODS: Fifty-six myopic children were divided into three groups: 32 children were treated with 0...
July 19, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27423689/parents-awareness-and-perception-of-children-s-eye-diseases-in-nigeria
#16
Jennifer A Ebeigbe, Chike Martin Emedike
PURPOSE: Most causes of childhood blindness are treatable or preventable. Knowledge of parents' awareness and perception of eye problems is important in helping to understand parents' eye care seeking behavior. This understanding becomes necessary as early detection and intervention can be effective when done at an early age. METHOD: Study was carried out in Benin City, Nigeria. Thirty-five parents aged 38-54 years with a mean age of 43(±2) years were recruited...
July 13, 2016: Journal of Optometry
https://www.readbyqxmd.com/read/27333331/eyedrop-vaccination-induced-systemic-and-mucosal-immunity-against-influenza-virus-in-ferrets
#17
Sangchul Yoon, Eun-Do Kim, Min-Suk Song, Soo Jung Han, Tae Kwann Park, Kyoung Sub Choi, Young-Ki Choi, Kyoung Yul Seo
We investigated eyedrop vaccination (EDV) in pre-clinical development for immunological protection against influenza and for potential side effects involving ocular inflammation and the central nervous system (CNS). Live attenuated influenza EDV, CA07 (H1N1), PZ-4 (H1N2) and Uruguay (H3N2), induced both systemic and mucosal virus-specific antibody responses in ferrets. In addition, EDV resulted in a clinically significant protection against viral challenge, and suppression of viral replication in nasal secretion and lung tissue...
2016: PloS One
https://www.readbyqxmd.com/read/27220708/-clinical-effects-of-gas-tamponade-followed-by-scleral-cryotherapy-on-rhegmatogenous-retinal-detachment
#18
Jieting She, Guoming Zhang, Jian Zeng, Yi Chen, Xuyang Liu, Hongbo Cheng
OBJECTIVE: To evaluate the effects of intravitreal injection of sterile air followed by scleral cryotherapy on simple rhegmatogenous retinal detachment (RRD). METHODS: Retrospective study. Thirty-five cases (thirty-five eyes) with RRD were collected from Oct 2013 to Mar 2014. Among them, macular detachment was observed in 31cases, all accompanied with obvious synchesis. All retinal breaks were horseshoe shaped and holes located above 9 o'clock to 3 o'clock position, with size ranged from 0...
May 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27196964/topical-delivery-of-a-rho-kinase-inhibitor-to-the-cornea-via-mucoadhesive-film
#19
Wendy Chan, Alina Akhbanbetova, Andrew J Quantock, Charles M Heard
The application of inhibitors of the Rho kinase pathway (ROCK inhibitors) to the surface of the eye in the form of eyedrops has beneficial effects which aid the recovery of diseased or injured endothelial cells that line the inner surface of the cornea. The aim of this study was to test the plausibility of delivering a selective ROCK inhibitor, Y-27632, to the cornea using a thin polymeric film. Mucoadhesive polymeric thin films were prepared incorporating Y-27632 and diffusional release into PBS was determined...
August 25, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27149661/novel-water-soluble-mucoadhesive-carbosilane-dendrimers-for-ocular-administration
#20
I Bravo-Osuna, M Vicario-de-la-Torre, V Andrés-Guerrero, J Sánchez-Nieves, M Guzmán-Navarro, F J de la Mata, R Gómez, B de Las Heras, P Argüeso, G Ponchel, R Herrero-Vanrell, I T Molina-Martínez
The purpose of this research was to determine the potential use of water-soluble anionic and cationic carbosilane dendrimers (generations 1-3) as mucoadhesive polymers in eyedrop formulations. Cationic carbosilane dendrimers decorated with ammonium -NH3(+) groups were prepared by hydrosylilation of Boc-protected allylamine and followed by deprotection with HCl. Anionic carbosilane dendrimers with terminal carboxylate groups were also employed in this study. In vitro and in vivo tolerance studies were performed in human ocular epithelial cell lines and rabbit eyes respectively...
September 6, 2016: Molecular Pharmaceutics
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