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High fat cornea nerves

Eric P Davidson, Amey Holmes, Lawrence J Coppey, Mark A Yorek
We have previously demonstrated that treating diabetic rats with enalapril, an angiotensin converting enzyme (ACE) inhibitor, α-lipoic acid, an antioxidant, or menhaden oil, a natural source of omega-3 fatty acids can partially improve diabetic peripheral neuropathy. In this study we sought to determine the efficacy of combining these three treatments on vascular and neural complications in a high fat fed low dose streptozotocin treated rat, a model of type 2 diabetes. Rats were fed a high fat diet for 8 weeks followed by a 30 mg/kg dose of streptozotocin...
October 15, 2015: European Journal of Pharmacology
Hanna Shevalye, Matthew S Yorek, Lawrence J Coppey, Amey Holmes, Matthew M Harper, Randy H Kardon, Mark A Yorek
The purpose of this study was to determine the effect of supplementing the diet of a mouse model of type 2 diabetes with menhaden (fish) oil or daily treatment with resolvin D1 on diabetic neuropathy. The end points evaluated included motor and sensory nerve conduction velocity, thermal sensitivity, innervation of sensory nerves in the cornea and skin, and the retinal ganglion cell complex thickness. Menhaden oil is a natural source for n-3 polyunsaturated fatty acids, which have been shown to have beneficial effects in other diseases...
July 2015: Journal of Neurophysiology
Jeffrey H Boatright, Nupur Dalal, Micah A Chrenek, Christopher Gardner, Alison Ziesel, Yi Jiang, Hans E Grossniklaus, John M Nickerson
PURPOSE: Our goal was to optimize procedures for assessing shapes, sizes, and other quantitative metrics of retinal pigment epithelium (RPE) cells and contact- and noncontact-mediated cell-to-cell interactions across a large series of flatmount RPE images. METHODS: The two principal methodological advances of this study were optimization of a mouse RPE flatmount preparation and refinement of open-access software to rapidly analyze large numbers of flatmount images...
2015: Molecular Vision
Eric P Davidson, Lawrence J Coppey, Randy H Kardon, Mark A Yorek
PURPOSE: Peripheral neuropathy has been shown to exist in prediabetic and diabetic patients and animal models. However, the development of peripheral neuropathy in prediabetes and posthyperglycemia is likely different. The purpose of this study was to examine the progression of peripheral neuropathy in diet-induced obese rats and high-fat-fed rats treated with a low dose of streptozotocin, a model for type 2 diabetes, using standard endpoints as well as corneal sensitivity and innervation...
March 2014: Investigative Ophthalmology & Visual Science
Eric P Davidson, Lawrence J Coppey, Amey Holmes, Mark A Yorek
PURPOSE: Corneal confocal microscopy is emerging as a clinical tool to evaluate the development and progression of diabetic neuropathy. The purpose of these studies was to characterize the changes in corneal sensitivity and innervation in a rat model of type 2 diabetes in relation to standard peripheral neuropathy endpoints. Assessment of diabetes-induced changes in corneal innervation and sensitivity in animal models will be important for determining the usefulness of corneal markers for preclinical studies to test potential new treatments for diabetic neuropathy...
March 2012: Investigative Ophthalmology & Visual Science
A J van den Eijnden-van Raaij, A L de Leeuw, H J Winkens, J F Kruisselbrink-Borgonjen, R M Broekhuyse
Proteins with high affinity and capacity for calcium are present in the membranes of calf lens fiber and epithelial cells. They can be extracted from these membranes by means of EDTA or EGTA. The tissue specificity and localization of these 30-38 kD EDTA-extractable proteins (EEP) have been examined. Antibodies raised against calf lens fiber EEP specifically form immune complexes with distinct proteins of 30-38 kD in a great variety of non-lenticular tissues. By indirect immunofluorescence microscopy using anti-EEP antiserum, the EEP-like proteins could be detected in fibroblasts, retinal Müller cells, endothelial cells and some types of epithelial cells...
August 1985: Experimental Cell Research
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