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https://www.readbyqxmd.com/read/29677207/sweat-glucose-and-glut2-expression-in-atopic-dermatitis-implication-for-clinical-manifestation-and-treatment
#1
Emi Ono, Hiroyuki Murota, Yuki Mori, Yoshichika Yoshioka, Yuko Nomura, Takichi Munetsugu, Hiroo Yokozeki, Ichiro Katayama
Sweat includes active components and metabolites, which are needed to maintain skin homeostasis. Component changes in sweat derived from atopic dermatitis (AD) have been reported. To investigate the influence of sweat components on the pathogenesis of AD, we performed a multifaceted assessment, including nuclear magnetic resonance spectroscopy-based metabolomic analysis, and linked these features to clinical features of AD. Distinctive properties of AD sweat are the quite-variation in protein, anti-microbial peptides and glucose concentrations...
2018: PloS One
https://www.readbyqxmd.com/read/29626974/a-young-man-with-hemoptysis-and-cavitary-lung-lesions
#2
Virginia A Brady, Andrey V Zinchuk, Mark D Siegel, Jennifer D Possick
A man in his 20s presented with 2 months of mild fatigue and intermittent hemoptysis of less than a tablespoon per episode. He was previously healthy and was on no medications. He denied fevers, night sweats, weight loss, wheezing, dyspnea, musculoskeletal symptoms, and rashes. He had emigrated from a South American country to the United States 3 years earlier. He worked as a groundskeeper but had no exposures to animals, mold, or dusts. He reported rare prior cigarette smoking with no history of alcohol or drug use...
April 2018: Chest
https://www.readbyqxmd.com/read/29619902/risk-factors-of-overactive-bladder-syndrome-and-its-relation-to-sexual-function-in-menopausal-women
#3
Sevil Hakimi, Elham Aminian, Sakineh Mohammad- Alizadeh Charandabi, Parvin Bastani, Marzieh Mohammadi
BACKGROUND: Overactive bladder syndrome is a common and annoying complication worldwide that could negatively affect the quality of life of afflicted individuals. We aimed to determine the prevalence and risk factors of overactive bladder syndrome and its relation to sexual function in healthy menopausal women. METHODS: This cross-sectional study was done on 340 women aged 45-60 years in Tabriz, northwest Iran, during 2015-2016. Data were collected using a demographic data questionnaire, the Overactive Bladder Syndrome Score, and the McCoy Female Sexuality Questionnaire...
February 2018: Urologia
https://www.readbyqxmd.com/read/29611353/intra-individual-biological-variation-in-sweat-chloride-concentrations-in-cf-cftr-dysfunction-and-healthy-pediatric-subjects
#4
Natalia Cirilli, Valeria Raia, Ilaria Rocco, Fabiola De Gregorio, Antonella Tosco, Laura Salvadori, Angela Ornella Sepe, Roberto Buzzetti, Nadia Minicuci, Giuseppe Castaldo
BACKGROUND: The sweat test is one of the main diagnostic tools used in newborn screening programs and as a confirmatory test, in case of suspect of Cystic Fibrosis (CF). Since sweat chloride (Cl) concentration is also considered an appropriate parameter to explore the efficacy of CFTR modulators in clinical trials, it is crucial to evaluate the biological variability of this test in healthy and pathological conditions. The aim of this pilot study was to determine the intra-individual biological variability of sweat Cl, both in healthy individuals and CF patients and to assess its correlation with diet, season, and menstrual cycle...
April 2, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29592995/a-rare-case-of-pyogenic-pericarditis-secondary-to-streptococcus-constellatus
#5
Sehem Ghazala, Todd Rabkin Golden, Sumaya Farran, Tirdad T Zangeneh
We report an extremely rare case of purulent pericarditis caused by the normally commensal oral flora, Streptococcus constellatus, a viridans Streptococcal species and member of the S. anginosus group (previously also known by the eponymous ' S. milleri', for American Willoughby Dayton Miller). This case is a previously healthy 71-year-old immunocompetent woman from Arizona who presented with a 5-day history of progressive shortness of breath and chest tightness, and subjective fever and chills, but without history of nausea, vomiting, night sweats, recent travel, autoimmune disease or sick contacts...
March 28, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29580829/sweat-test-for-cystic-fibrosis-wearable-sweat-sensor-vs-standard-laboratory-test
#6
Dong-Hoon Choi, Abigail Thaxton, In Cheol Jeong, Kain Kim, Patrick R Sosnay, Garry R Cutting, Peter C Searson
BACKGROUND: Sweat chloride testing for diagnosis of cystic fibrosis (CF) involves sweat induction, collection and handling, and measurement in an analytical lab. We have developed a wearable sensor with an integrated salt bridge for real-time measurement of sweat chloride concentration. Here, in a proof-of-concept study, we compare the performance of the sensor to current clinical practice in CF patients and healthy subjects. METHOD: Sweat was induced on both forearms of 10 individuals with CF and 10 healthy subjects using pilocarpine iontophoresis...
March 23, 2018: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29556238/immunotopographical-differences-of-human-skin
#7
Gabriella Béke, Zsolt Dajnoki, Anikó Kapitány, Krisztián Gáspár, Barbara Medgyesi, Szilárd Póliska, Zoltán Hendrik, Zoltán Péter, Dániel Törőcsik, Tamás Bíró, Andrea Szegedi
The immunological barrier of the healthy skin is considered to be unified on the whole body surface-however, recent indirect findings have challenged this dogma since microbial and chemical milieu (e.g., sebum, sweat, and pH) exhibit remarkable differences on topographically distinct skin areas. Therefore, in the present study, we performed whole transcriptomic and subsequent pathway analyses to assess differences between sebaceous gland rich (SGR) and sebaceous gland poor (SGP) regions. Here, we provide the first evidence that different skin regions exhibit a characteristic innate and adaptive immune and barrier milieu as we could detect significantly increased chemokine (CCL2, 3, 19, 20, 23, 24) and antimicrobial peptide (S100A7, A8, A9, lipocalin, β-defensin-2) expression, altered barrier (keratin 17, 79) functions, and a non-inflammatory Th17/IL-17 dominance in SGR skin compared to SGP...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29523179/a-young-female-presenting-with-heart-failure-secondary-to-eosinophilic-myocarditis-a-case-report-and-review-of-the-literature
#8
Dissanayake Mudiyanselage Priyantha Udaya Kumara Ralapanawa, Kulatunga Wijekoon Mudiyanselage Pramitha Prabhashini Kumarihamy, Miriyalini Sundararajah, Widana Arachchilage Thilak Ananda Jayalath
BACKGROUND: Eosinophilic myocarditis is one of the fatal complications of idiopathic hypereosinophilic syndromes. Given the rarity of this form of myocarditis, it is often under-recognized. We describe a young girl who presented with features of heart failure. To our knowledge, this is the first reported case of eosinophilic myocarditis in a young Sri Lankan female. CASE PRESENTATION: A previously healthy 21 year old Sri Lankan female admitted with shortness of breath for 1 week duration with associated low grade fever and profuse sweating...
March 9, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29522648/the-effects-of-the-selective-muscarinic-m3-receptor-antagonist-darifenacin-and-of-hyoscine-scopolamine-on-motion-sickness-skin-conductance-cognitive-function
#9
J F Golding, K A Wesnes, B R Leaker
AIMS: The aim of this study was to compare the effects of the selective M3 muscarinic acetylcholine receptor antagonist Darifenacin, oral Hyoscine hydrobromide and Placebo on motion sickness induced by cross-coupled stimulation. METHODS: The effects of Darifenacin 10 mg or 20 mg, Hyoscine hydrobromide 0.6 mg and Placebo were assessed in a randomised, double-blind, 4-way cross over trial of 16 healthy subjects. Motion sickness, skin conductance (a measure of sweating) and psychomotor cognitive function tests were investigated...
March 9, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29504986/impending-thyroid-storm-in-a-pregnant-woman-with-undiagnosed-hyperthyroidism-a-case-report-and-literature-review
#10
REVIEW
Yushan Ma, Hao Li, Jin Liu, Xuemei Lin, Hui Liu
RATIONALE: Thyroid storm is a rare complication during caesarean section of patients with hyperthyroidism. It occurs abruptly, with a high mortality rate if not recognized immediately and aggressively treated. Herein, we reported a case of impending thyroid storm during a caesarean section. PATIENT CONCERNS: A healthy 23-year-old woman with undiagnosed hyperthyroidism underwent an emergency caesarean section under general anesthesia. After tracheal extubation, the patient exhibited abnormal tachycardia, agitation, sweating, and hyperpyrexia...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29463352/precooling-and-warm-up-effects-on-time-trial-cycling-during-heat-stress
#11
Ramzi A Al-Horani, Jonathan E Wingo, Jason Ng, Phillip Bishop, Mark Richardson
BACKGROUND: Heat stress limits endurance exercise performance. Combining precooling and warm-up prior to endurance exercise in the heat may exploit the benefits of both strategies while avoiding the potential negative consequences of each. This study tested the hypothesis that precooling combined with warm-up improves time trial cycling performance in the heat relative to either treatment alone. METHODS: Nine healthy men completed three 16.1-km time trials in 33°C after: 1) precooling (ice slurry and ice vest) alone (PREC); 2) warm-up alone (WU); or 3) PREC plus WU (COMBO)...
February 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29393227/acute-menopausal-symptoms-in-young-cancer-survivors-immediately-following-chemotherapy
#12
Katherine E Cameron, Martha B Kole, Mary D Sammel, Jill P Ginsberg, Yasmin Gosiengfiao, Jennifer E Mersereau, H Irene Su, Clarisa R Gracia
PURPOSE: The aim of this study was to evaluate the prevalence of menopausal symptoms in young cancer survivors immediately following the completion of chemotherapy. METHODS: This prospective cohort study followed 124 young females with a new diagnosis of cancer requiring chemotherapy to assess symptoms of menopause before treatment and immediately following chemotherapy. Symptoms were compared before and after treatment using the McNemar test and between cancer patients and 133 similar-aged healthy controls using Pearson χ2 and Fisher's exact tests...
January 26, 2018: Oncology
https://www.readbyqxmd.com/read/29390162/androstadienone-a-chemosignal-found-in-human-sweat-increases-individualistic-behavior-and-decreases-cooperative-responses-in-men
#13
A Banner, I Frumin, S G Shamay-Tsoory
A growing body of evidence suggests that humans can communicate socially relevant information, such as aggression, dominance and readiness for competition, through chemosensory signals. Androstadienone (androsta-4,16,-dien-3-one), a testosterone-derived compound found in men's axillary sweat, is a main candidate for a human pheromone that may convey such information. The current study aimed to investigate whether androstadienone serves as a chemosignaling threat cue to men, thus triggering avoidance behavior during competitive interaction with another man...
January 30, 2018: Chemical Senses
https://www.readbyqxmd.com/read/29344666/let-7b-regulates-alpaca-hair-growth-by-downregulating-ectodysplasin-a
#14
Ning Liu, Shu Niu, Xiao-Rui Cao, Jia-Qi Cheng, Shu-Yuan Gao, Xiu-Ju Yu, Hai-Dong Wang, Chang-Sheng Dong, Xiao-Yan He
Hypohidrotic ectodermal dysplasia (HED), also known as anhidrotic ectodermal dysplasia, is characterized by the clinical manifestations of less sweat or no sweat, sparse or no hair, tooth agenesis and/or abnormal tooth morphology. The characteristics of alpaca ear hair differ from the back hair. The ectodysplasin A (EDA) signaling pathway has a regulatory effect on skin development and hair growth. The aim of the present study was to study the effects of EDA on alpaca hair growth by examining the mRNA and protein expression levels of EDA in alpaca ear and back skin by reverse transcription‑quantitative polymerase chain reaction and western blot analysis, respectively...
January 17, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29339313/the-human-body-odor-compound-androstadienone-increases-neural-conflict-coupled-to-higher-behavioral-costs-during-an-emotional-stroop-task
#15
Jonas Hornung, Lydia Kogler, Michael Erb, Jessica Freiherr, Birgit Derntl
The androgen derivative androstadienone (AND) is a substance found in human sweat and thus may act as human chemosignal. With the current experiment, we aimed to explore in which way AND affects interference processing during an emotional Stroop task which used human faces as target and emotional words as distractor stimuli. This was complemented by functional magnetic resonance imaging (fMRI) to unravel the neural mechanism of AND-action. Based on previous accounts we expected AND to increase neural activation in areas commonly implicated in evaluation of emotional face processing and to change neural activation in brain regions linked to interference processing...
May 1, 2018: NeuroImage
https://www.readbyqxmd.com/read/29338740/is-sweat-testing-for-cystic-fibrosis-feasible-in-patients-with-down-syndrome
#16
Katharina Ruf, Antonia Demerath, Helge Hebestreit, Steffen Kunzmann
BACKGROUND: Recurrent airway infections are common in patients with Down's syndrome (DS). Hence, ruling out Cystic Fibrosis (CF) in these patients is often required. In the past, the value of sweat testing - the gold standard to diagnose CF - has been questioned in DS as false positive results have been reported. However, these reports are based on measurements of sweat osmolality or sodium concentrations, not chloride concentrations. This study analyses sweat secretion rate and chloride concentration in sweat samples of patients with DS in comparison to healthy controls...
January 16, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29321926/lung-injury-associated-with-electronic-cigarettes-inhalation-diagnosed-by-transbronchial-lung-biopsy
#17
Masayuki Itoh, Kazutetsu Aoshiba, Yoriko Herai, Hiroyuki Nakamura, Tamiko Takemura
A 46-year-old healthy man developed respiratory distress, night sweats, fever, and weight loss after using electronic cigarettes (e-cigs) for approximately 1 month. He presented to the hospital when the symptoms worsened 2 months after onset. The findings of bronchoalveolar lavage (BAL) fluid examination and the following transbronchial lung biopsy examination led to the diagnosis of acute alveolitis: intra-alveolar fibrosis accompanied with exudate containing abundant lipid-laden macrophages, eosinophils, and neutrophils...
January 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29301696/heat-acclimation-causes-a-linear-decrease-in-sweat-sodium-ion-concentration
#18
Michael J Buono, Mark Kolding, Eric Leslie, Daniel Moreno, Sarah Norwood, Andrew Ordille, Rebecca Weller
The purpose of this study was to determine the time course for the previously reported reduction in sweat sodium ion concentration during heat acclimation. Four healthy volunteers completed 7 consecutive days of heat acclimation which included 2h of treadmill walking in a 40°C and 40% relative humidity environment. A modified constant hyperthermia protocol was used as workloads were increased each day to maintain a constant core temperature over the 7 days of heat acclimation. Forearm sweat was collected 3 times during each 2h exercise bout on days 1, 3, 5, and 7 of heat acclimation...
January 2018: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29246659/bayesian-informed-evidence-against-modulation-of-androstadienone-effects-by-genotypic-receptor-variants-and-participant-sex-a-study-assessing-stroop-interference-control-mood-and-olfaction
#19
Jonas Hornung, Hannes Noack, Mara Thomas, Gisbert Farger, Vanessa Nieratschker, Jessica Freiherr, Birgit Derntl
The androgen derivative androstadienone (AND) is present in human sweat and may act as human chemosignal. Though effects of AND have been reported with respect to emotional and cognitive processes, results have been highly inconsistent. For this reason, it is likely that AND-action is dependent on modulatory factors. Here we wanted to specifically investigate the impact of genotypic variations of the AND-receptor OR7D4, as well as the influence of participant sex and concomitant hormonal fluctuations on AND-action during emotional interference processing, olfactory performance and mood assessments...
February 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29238692/migraine-related-vertigo
#20
Vithal D Udagatti, Rajendran Dinesh Kumar
Migraine related vertigo (MRV) is largely accepted in the vestibular community and probably represents the second most common cause of vertigo after benign positional vertigo by far exceeding Meniere's disease. The data on vestibular migraine management is still relatively poor, despite its enormous importance in daily practice. A 55-year old male presented with history of giddiness, imbalance, sweating and sensation of nausea with severe pulsating headache of one day duration. Ear, Nose and Throat examination was normal...
December 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
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