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https://www.readbyqxmd.com/read/28343568/thermogenic-and-psychogenic-recruitment-of-human-eccrine-sweat-glands-variations-between-glabrous-and-non-glabrous-skin-surfaces
#1
Christiano A Machado-Moreira, Nigel A S Taylor
Human eccrine sweat-gland recruitment and secretion rates were investigated from the glabrous (volar) and non-glabrous hand surfaces during psychogenic (mental arithmetic) and thermogenic stimuli (mild hyperthermia). It was hypothesised that these treatments would activate glands from both skin surfaces, with the non-thermal stimulus increasing secretion rates primarily by recruiting more sweat glands. Ten healthy men participated in two seated, resting trials in temperate conditions (25-26°C). Trials commenced under normothermic conditions during which the first psychogenic stress was applied...
April 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28295553/serum-carcinoembryonic-antigen-specifically-increases-among-various-serum-markers-of-adenocarcinoma-in-hypohidrosis-or-conditions-related-to-hypohidrosis
#2
Masaru Honma, Hiroyoshi Nozaki, Hiroko Nagahata, Mizue Fujii, Takashi Shibuya, Kyoko Kanno, Masako Minami-Hori, Akemi Ishida-Yamamoto
Anhidrosis/hypohidrosis are conditions presenting various level of sweating dysfunction. Among them, acquired idiopathic generalized anhidrosis (AIGA) presents inadequate decrease or loss of sweating without apparent neurological and dermatological symptoms except cholinergic urticaria. Recently, serum level of carcinoembryonic antigen (CEA), one of the most well-known tumor markers, has been proposed as a clinical marker reflecting activity of AIGA. This study was performed to verify the specificity and independence of serum CEA level from the other serum tumor markers especially related to adenocarcinoma...
March 11, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28275061/impaired-sweating-responses-to-a-passive-whole-body-heat-stress-in-individuals-with-multiple-sclerosis
#3
Dustin R Allen, Mu Huang, Iqra M Parupia, Ariana R Dubelko, Elliot M Frohman, Scott L Davis
Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system (CNS), disrupting autonomic function. The aim of this study was to test the hypothesis that individuals with MS have blunted control of thermoregulatory reflex increases in sweat rate (SR) and cutaneous vasodilation compared to controls during a passive whole-body heat stress (WBH). Eighteen individuals with relapsing-remitting MS and 18 healthy controls (CON) participated in the study. Core temperature (Tcore), skin temperature, heart rate, arterial blood pressure (10 min intervals), skin blood flow (laser-Doppler flux: LDF), and SR were continuously measured during normothermic baseline (34 °C water perfusing a tube-lined suit) and WBH (increased Tcore 0...
March 8, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28272337/impact-of-isotonic-beverage-on-the-hydration-status-of-healthy-chinese-adults-in-air-conditioned-environment
#4
Phei Ching Siow, Wei Shuan Kimberly Tan, Christiani Jeyakumar Henry
People living in tropical climates spend much of their time in confined air-conditioned spaces, performing normal daily activities. This study investigated the effect of distilled water (W) or isotonic beverage (IB) on the hydration status in subjects living under these conditions. In a randomized crossover design, forty-nine healthy male subjects either consumed beverage or IB over a period of 8 h (8 h) in a controlled air-conditioned environment. Blood, urine, and saliva samples were collected at baseline and after 8 h...
March 7, 2017: Nutrients
https://www.readbyqxmd.com/read/28265410/adolescents-with-full-or-subthreshold-anorexia-nervosa-in-a-naturalistic-sample-characteristics-and-treatment-outcome
#5
Katarina Lindstedt, Lars Kjellin, Sanna Aila Gustafsson
BACKGROUND: Anorexia Nervosa (AN) destroys developmentally important early years of many young people and knowledge is insufficient regarding course, treatment outcome and prognosis. Only a few naturalistic studies have been conducted within the field of eating disorder (ED) research. In this naturalistic study we included adolescents with AN or subthreshold AN treated in outpatient care, and the overall aim was to examine sample characteristics and treatment outcome. Additional aims were to examine potential factors associated with remission as an outcome variable, and possible differences between three time periods for treatment onset...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/28256922/obese-adolescents-show-reduced-cognitive-processing-speed-compared-with-healthy-weight-peers
#6
Victoria Sweat, Kathy F Yates, Renee Migliaccio, Antonio Convit
BACKGROUND: Childhood obesity and obesity-associated diabetes and metabolic syndrome (MetS) continue to rise. Obesity has been linked to structural and functional brain abnormalities, particularly in the frontal lobe. METHODS: One hundred sixty-two adolescents (aged 19.53 ± 1.53 years) underwent medical, neurocognitive, and brain magnetic resonance imaging assessments. Participants were either healthy weight (BMI <25.0 kg/m(2) or BMI percentile <85%) or obese (BMI ≥30...
March 3, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28240705/skin-tattoos-alter-sweat-rate-and-na-concentration
#7
Maurie Joe Luetkemeier, Joseph Michael Hanisko, Kyle Mathiew Aho
The popularity of tattoos has increased tremendously in the last 10-years particularly among athletes and military personnel. The tattooing process involves permanently depositing ink under the skin at a similar depth as eccrine sweat glands (3-5 mm). PURPOSE: The purpose of this study was to compare the sweat rate and sweat Na concentration of tattooed vs. non-tattooed skin. METHODS: The participants were 10 healthy males (age = 21 ± 1 yr) all with a unilateral tattoo covering a circular area at least 5...
February 25, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28209466/pharmacokinetics-and-safety-of-cavosonstat-n91115-in-healthy-and-cystic-fibrosis-adults-homozygous-for-f508del-cftr
#8
Scott H Donaldson, George M Solomon, Pamela L Zeitlin, Patrick A Flume, Alicia Casey, Karen McCoy, Edith T Zemanick, Arun Mandagere, Janice M Troha, Steven A Shoemaker, James F Chmiel, Jennifer L Taylor-Cousar
BACKGROUND: Cavosonstat (N91115), an orally bioavailable inhibitor of S-nitrosoglutathione reductase, promotes cystic fibrosis transmembrane conductance regulator (CFTR) maturation and plasma membrane stability, with a mechanism of action complementary to CFTR correctors and potentiators. METHODS: A Phase I program evaluated pharmacokinetics, drug-drug interactions and safety of cavosonstat in healthy and cystic fibrosis (CF) subjects homozygous for F508del-CFTR...
February 13, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28202441/effect-of-hypohydration-on-postsynaptic-cutaneous-vasodilation-and-sweating-in-healthy-men
#9
Matthew A Tucker, Ashley Six, Nicole E Moyen, Alf Z Satterfield, Matthew S Ganio
Hypohydration decreases cutaneous vasodilation and sweating during heat stress, but it is unknown if these decrements are from postsynaptic (i.e. sweat gland/blood vessel) alterations. PURPOSE: To determine if hypohydration affects postsynaptic cutaneous vasodilation and sweating responses. METHODS: 12 healthy men participated in euhydrated (EU) and hypohydrated (HY) trials, with hypohydration induced via fluid restriction and passive heat-stress. Changes in cutaneous vascular conductance (CVC; %max) in response to incremental intradermal infusion of the endothelium-independent vasodilator sodium nitroprusside (SNP) and the endothelium-dependent vasodilator methacholine chloride (MCh) were assessed by laser Doppler flowmetry...
February 15, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28197350/disseminated-mycobacterium-interjectum-infection-with-bacteremia-hepatic-and-pulmonary-involvement-associated-with-a-long-term-catheter-infection
#10
David Sotello, D Jane Hata, Mohammed Reza, Raj Satyanarayana, Vichaya Arunthari, Wendelyn Bosch
We present a 49-year-old female with one year of intermittent fevers, chills, night sweats, and significant weight loss. Liver and lung biopsy showed evidence of a granulomatous process. Blood and liver biopsy cultures yielded growth of presumed Mycobacterium interjectum, thought to be related to a disseminated long-term central venous catheter infection. She successfully received one year of combined antimicrobial therapy after catheter removal without recurrence of disease. M. interjectum has been previously described as a cause of lymphadenitis in healthy children and associated with pulmonary disease in adults, although other localized infections have been reported...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28193033/wearable-potentiometric-chloride-sweat-sensor-the-critical-role-of-the-salt-bridge
#11
Dong-Hoon Choi, Jin Seob Kim, Garry R Cutting, Peter C Searson
The components of sweat provide an array of potential biomarkers for health and disease. Sweat chloride is of interest as a biomarker for cystic fibrosis, electrolyte metabolism disorders, electrolyte balance, and electrolyte loss during exercise. Developing wearable sensors for biomarkers in sweat is a major technological challenge. Potentiometric sensors provide a relatively simple technology for on-body sweat chloride measurement, however, equilibration between reference and test solutions has limited the time over which accurate measurements can be made...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28161081/validation-of-a-self-report-questionnaire-assessing-the-bodily-and-physiological-sensations-of-orgasm
#12
Samantha Dubray, Marina Gérard, Dominic Beaulieu-Prévost, Frédérique Courtois
INTRODUCTION: Despite a plethora of research on sexual functioning during the past decades, the field is still lacking standardized measurements specifically characterizing orgasm. Although several validated tools are available to assess sexual function in healthy and clinical populations, items on orgasm are limited to frequency or dichotomous responses. A neurophysiologic model of orgasm developed from previous research in able-bodied and spinally injured populations offers a promising framework for the construction of a new questionnaire...
February 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28137333/sit-step-sweat-longitudinal-associations-between-physical-activity-patterns-anxiety-and-depression
#13
S A Hiles, F Lamers, Y Milaneschi, B W J H Penninx
BACKGROUND: Physical inactivity has been identified as a risk factor for depression and, less often, as a long-term consequence of depression. Underexplored is whether similar bi-directional longitudinal relationships are observed for anxiety disorders, particularly in relation to three distinct indicators of activity levels - sports participation, general physical activity and sedentary behavior. METHOD: Participants were from the Netherlands Study of Depression and Anxiety (NESDA; N = 2932, 18-65 years old; 57% current anxiety or depressive disorder, 21% remitted disorder, 22% healthy controls)...
January 31, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28095327/proteomic-and-peptidomic-analysis-of-human-sweat-with-emphasis-on-proteolysis
#14
Yijing Yu, Ioannis Prassas, Carla M J Muytjens, Eleftherios P Diamandis
Sweat is produced by eccrine and apocrine glands and represents a biological fluid with established roles in thermo-regulation and host infection defense. The composition of sweat is highly dynamic and alters significantly in various skin and other disorders. Therefore, in-depth profiling of sweat protein composition is expected to augment our understanding of the pathobiology of several skin diseases and may lead to the identification of useful sweat-based disease biomarkers. We here reported an in-depth analysis of the human sweat proteome and peptidome...
January 14, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28075427/evaluation-of-sudomotor-function-in-adult-patients-with-long%C3%A2-lasting-type-1-diabetes
#15
Agnieszka Gandecka, Aleksandra Araszkiewicz, Stanisław Piłaciński, Bogna Wierusz-Wysocka, Dorota Zozulińska-Ziółkiewicz
INTRODUCTION The function of the sweat glands appears to be impaired in patients with diabetic complications. OBJECTIVES The aim of the study was to evaluate sudomotor function in adult patients with type 1 diabetes (DM1) and healthy controls and its relationship with metabolic control and diabetic complications. PATIENTS AND METHODS The study group included 404 patients with DM1 (194 women), aged 41 years (interquartile range [IQR], 32-51 years) and with disease duration of 23 years (IQR, 18-31 years). The control group included 84 healthy volunteers...
January 10, 2017: Pol Arch Intern Med
https://www.readbyqxmd.com/read/28050930/the-effects-of-crushed-ice-ingestion-prior-to-steady-state-exercise-in-the-heat
#16
Matthew Zimmermann, Grant Landers, Karen E Wallman, Jacinta Saldaris
This study examined the physiological effects of crushed ice ingestion prior to steady state exercise in the heat. Ten healthy males with age (23±3 y), height (176.9±8.7 cm), body-mass (73.5±8.0 kg), V̇O2peak (48.5±3.6 mL·kg·min(-1)) participated in the study. Participants completed 60 min of cycling at 55% of their V̇O2peak preceded by 30 min of pre-cooling whereby 7 g·kg(-1) of thermoneutral water (CON) or crushed ice (ICE) was ingested. The reduction in Tc at the conclusion of pre-cooling was greater in ICE (-0...
January 4, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/27998494/pattern-of-socio-economic-and-health-aspects-among-tb-patients-and-controls
#17
A K Kapoor, Vijit Deepani, Meenal Dhall, Satwanti Kapoor
BACKGROUND: Socio-economic and health-related factors have a significant impact on tuberculosis (TB) incidence among population residing in resource-scare settings. OBJECTIVE: To evaluate the pattern of socio-economic and health-related factors among TB patients and control in Delhi, India. METHODS: The present cross-sectional study was performed among 893 TB patients (or cases) and 333 healthy disease-free controls. The data for the present study was obtained from several district TB centres in north, west and south Delhi...
October 2016: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/27976805/mutations-in-crlf1-cause-familial-achalasia
#18
Anne Busch, Milena Žarković, Chrishanthi Lowe, Martin Jankofsky, Rainer Ganschow, Insa Buers, Ingo Kurth, Heiko Reutter, Frank Rutsch, Christian A Hübner
We here report a family from Libya with 3 siblings suffering from early onset achalasia born to healthy parents. We analyzed roughly 5,000 disease-associated genes by a next generation sequencing approach. In the analyzed sibling we identified 2 heterozygous variants in CRLF1 (Cytokine Receptor-Like Factor 1). Mutations in CRLF1 have been associated with autosomal recessive Crisponi or cold-induced sweating syndrome type 1 (CS/CISS1), which among other symptoms also manifests with early onset feeding difficulties...
December 15, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/27951626/diagnostic-role-of-mean-platelet-volume-and-neutrophil-to-lymphocyte-ratio-in-childhood-brucellosis
#19
Şefika Elmas Bozdemir, Yasemin Ay Altıntop, Salih Uytun, Humeyra Aslaner, Yasemin Altuner Torun
Background/Aims: Brucellosis patients present various non-specific clinical symptoms, such as fever, fatigue, sweating, joint pain, arthritis, myalgia, and headache. Based on the nonspecifity of its clinical signs and symtoms, we decided to evaluate whether mean platelet volume (MPV) , neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) will contribute to the diagnosis. Methods: In this retrospective study, we reviewed hospital-records of 60 children with a confirmed diagnosis of brucellosis in Kayseri between January 2013 and January 2016, and compared the hematological parameters; white blood cell (WBC) count, hemoglobin (Hb), neutrophil count, lymphocyte count, platelet count, MPV, NLR, and PLR with 55 healthy age and gender matched children...
December 14, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27926760/epidermal-nerve-fiber-quantification-in-patients-with-erythromelalgia
#20
William G Mantyh, P James B Dyck, Peter J Dyck, Janean K Engelstad, William J Litchy, Paola Sandroni, Mark D P Davis
Importance: Erythromelalgia is a clinical diagnosis based on intermittent warmth, erythema, and pain in the distal extremities. One problem facing physicians is how to objectively test for this disease. Given that other painful conditions of the distal extremities (ie, neuropathy related to human immunodeficiency virus, diabetes, or Fabry disease) can be evaluated with a skin biopsy to visualize pathologically decreased densities of the small nerve fibers that innervate the epidermis, one hypothesis is that erythromelalgia could similarly be associated with a loss of epidermal nerve fiber density (ENFD)...
December 7, 2016: JAMA Dermatology
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