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Sweating healthy

Baohan Pan, Kelly Byrnes, Mary Schwartz, C David Hansen, Claudia M Campbell, Malvina Krupiczojc, Michael J Caterina, Michael Polydefkis
We compared patterns of intraepidermal nerve fibers and mechanoreceptors from affected and unaffected plantar skin from patients with pachyonychia congenita (PC) and control subjects. Plantar biopsies from 10 genetically confirmed patients with PC (with a mutation in KRT6A) were performed at the ball of the foot (affected skin) and the arch (unaffected) and were compared to biopsies from corresponding locations in 10 control subjects. Tissue was processed to visualize intraepidermal nerve fibers (IENF) (PGP9...
October 20, 2016: Pain
Jorge Aburto-Corona, Luis Aragón-Vargas
CONTEXT:  Sunscreen lotions are important to protect the skin during outdoor exercise, but they may interfere with sweating. OBJECTIVE:  To measure the effect of 2 water-resistant sunscreens on local sweat production in men and women exercising in the heat and to compare those effects with the expected inhibition resulting from the use of an antiperspirant. DESIGN:  Randomized crossover study. SETTING:  Exercise in the heat (ambient temperature = 30...
October 14, 2016: Journal of Athletic Training
Tatsuro Amano, Masaki Ishitobi, Yukio Ogura, Yoshimitsu Inoue, Shunsaku Koga, Takeshi Nishiyasu, Narihiko Kondo
Changing stride frequency may influence oxygen uptake and heart rate during running as a function of running economy and central command. This study investigated the influence of stride frequency manipulation on thermoregulatory responses during endurance running. Seven healthy endurance runners ran on a treadmill at a velocity of 15km/h for 60min in a controlled environmental chamber (ambient temperature 27°C and relative humidity 50%), and stride frequency was manipulated. Stride frequency was intermittently manipulated by increasing and decreasing frequency by 10% from the pre-determined preferred frequency...
October 2016: Journal of Thermal Biology
Wandee Thiangtum, J Thomas Schonewille, Martin Wa Verstegen, Supot Arsawakulsudhi, Theera Rukkwamsuk, Wouter H Hendriks
BACKGROUND: Factorial determination of the sodium (Na) requirement of heat stressed lactating cows is hindered by accurate estimates of the Na losses through sweat. Direct studies, therefore, may be needed requiring information on the time course of healthy animals to become Na depleted and the subsequent rate of repletion. The rate of Na depletion and subsequent rate of Na repletion with two levels of dietary Na to lactating dairy cows housed under tropical conditions was investigated using the salivary Na/K...
October 3, 2016: Journal of the Science of Food and Agriculture
F Alby-Laurent, N Honoré-Goldman, A Cavau, N Bellon, S Allali, V Abadie
INTRODUCTION: Exposure to metallic mercury can cause severe accidental intoxications in children, whose clinical symptoms can vary depending on the route of administration, the dose, as well as the time and duration of the exposure. It has become unusual in France, yet it must be considered when taking a patient's medical history in cases of multisystemic involvement without a clear explanation. CLINICAL CASE: We report the case of a 12-year-old patient hospitalized because of a cough, poor general condition, chills, night sweats, psychomotor retardation, and skin lesions that had been developing for several weeks...
September 27, 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Farrukh Jamal, Quazi S Haque, Sangram Singh
BACKGROUND: Diverse group of agro-chemicals are indiscriminately sprayed by the farmers for pest control to enhance crop yield. About 25 million agricultural workers in the developing world suffer from at least one episode of poisoning each year, mainly by anticholinesterase- like organophosphates (OPs). OBJECTIVE: The present study was aimed to establish the OP toxicity in 187 occupationally exposed pesticide sprayers of mango plantation in rural Malihabad, Lucknow, in terms of neuro-cognitive impairment, mental health status, clinical symptoms, diabetes, and hematological factors...
2016: Open Biochemistry Journal
Aurora Van de Loo, Marlou Mackus, Gerdien Korte-Bouws, Karel Brookhuis, Johan Garssen, Joris Verster
BACKGROUND: The aim of this study was to examine the relationship between urine ethanol concentration and alcohol hangover severity. METHODS: N = 36 healthy social drinkers participated in a naturalistic study, comprising a hangover day and a control day. N = 18 of them have regular hangovers (the hangover group), while the other N = 18 claim to be hangover immune (hangover-immune group). On each test day at 9.30 am, urine samples were collected. Participants rated their overall hangover severity on a scale from 0 (absent) to 10 (extreme), as well as 18 individual hangover symptoms...
September 28, 2016: Psychopharmacology
Young Oh Shin, Jeong-Beom Lee, Jeong-Ho Kim
The quantitative sudomotor axon reflex testing (QSART) is a classic test of routine postganglionic sudomotor function. We investigated sudomotor function by QSART after summer (July 2012) and winter (January 2013) seasonal acclimation (SA) in the Republic of Korea. QSART with acetylcholine (ACh) iontophoresis were performed to determine directly activated (DIR) and axon reflex-mediated (AXR1, 2) sweating rate. Onset time of axon reflex, activated sweat gland density (ASGD), activated sweat gland output (ASGO), tympanic and skin temperatures (Tty, Tsk), basal metabolic rate (BMR), and evaporative loss volume changes were measured...
September 2016: Korean Journal of Physiology & Pharmacology
Olga A Wudarczyk, Nils Kohn, Rene Bergs, Katharina S Goerlich, Raquel E Gur, Bruce Turetsky, Frank Schneider, Ute Habel
Recent evidence suggests that humans can communicate emotion via chemosensory signals. Olfactory cues signaling anxiety can bias the perception of ambiguous stimuli, but the underlying neurobiological mechanisms of this effect are currently unknown. Here, we investigated the brain responses to subtle changes in facial expressions in response to anxiety chemosensory cues. Ten healthy individuals donated their sweat in two situations: while anticipating an important oral examination (anxiety condition) and during physical exercise (control condition)...
September 2, 2016: NeuroImage
Rebecca A Sundling, Eric So, Daniel B Logan
: Chondroid syringoma is a cutaneous sweat gland tumor. Despite its relative rarity, a benign and malignant variant have been described. We present a case report of chondroid syringoma of the foot in a healthy patient. Definitive diagnosis required histopathologic examination, while treatment included wide resection. Surgeons who are presented with a painless, solid nodule in the lower extremities should be cognizant of this neoplasm. LEVELS OF EVIDENCE: Therapeutic, Level IV: Case report...
September 1, 2016: Foot & Ankle Specialist
Hiroyuki Murota
Sweating disorders are sometimes observed in various systemic diseases that include genetic disorders, organ damage, metabolic impairment, autoimmune diseases, and neuropathic disorders. In these diseases, various symptoms such as autonomic failures, psychopathic disorders, abnormal skin innervation, and sweat gland dysfunction can interact with one another in diverse ways, resulting in impaired sweating. This review focuses on the influence of uremia (with or without hemodialysis) and diabetes mellitus on impaired sweating...
2016: Current Problems in Dermatology
Timo Siepmann, Elka Frenz, Ana Isabel Penzlin, Susan Goelz, Wagner Zago, Ingeborg Friehs, Marie Luise Kubasch, Miriam Wienecke, Matthias Löhle, Wiebke Schrempf, Kristian Barlinn, Joachim Siegert, Alexander Storch, Heinz Reichmann, Ben Min-Woo Illigens
INTRODUCTION: Autonomic nervous system disturbances including sweating abnormalities and cardiovascular symptoms are frequent in Parkinson's disease (PD) and often precede motor involvement. Cholinergic vasomotor and sudomotor skin nerves are impaired in patients with PD even at early disease stages. We hypothesized that adrenergic pilomotor nerve function is similarly impaired in early PD and might constitute a novel diagnostic target. METHODS: We conducted a study in 12 PD patients (Hoehn&Yahr 1-2) and 12 healthy control subjects...
October 2016: Parkinsonism & related Disorders
Ximena DeCaire, Erin Streu
A previously healthy, 30-year-old Filipino woman presented to an emergency department with complaints of shortness of breath and mild cough. She denied constitutional symptoms, such as night sweats, fevers, loss of appetite, or weight loss. Additional investigation revealed bilateral pleural and pericardial effusions with no obvious lung lesions or masses. The pericardial fluid was drained and preliminary cytology revealed atypical carcinoma cells. Her past medical history included an embryonic pregnancy and a benign breast cyst that was biopsied in the Philippines...
September 1, 2016: Oncology Nursing Forum
Kazuho Kojima, Shigeki Hirano
Central mechanisms of thermal and emotional sweating has been elucidated by using functional MRI in healthy human subjects. The hypothalamus (preoptic region) was specifically activated during thermal sweating, whereas prefrontal regions, insula, and anterior cingulate were activated during emotional sweating. Both thermal and emotional sweating were associated with activation in the dorsal midbrain and in the rostral lateral medulla. These results suggested that sweating in human represents not only sympathetic activation but also integrates emotional function, internal awareness, and attentional arousal in humans...
August 2016: Brain and Nerve, Shinkei Kenkyū No Shinpo
Vijaita Syngle, Ashit Syngle, Nidhi Garg, Pawan Krishan, Inderjeet Verma
OBJECTIVE: Autonomic dysfunction occurs in rheumatoid arthritis (RA). However, the association between the autonomic dysfunction and inflammation has not been investigated in RA. We investigated the relationship between inflammation and ANS function in RA. METHODS: In this cross-sectional study, 25 RA patients and 25 age and sex-matched healthy controls were recruited. Autonomic function assessed by five cardiovascular reflex tests according to Ewing. Parasympathetic dysfunction established by applying three tests: heart rate response to deep breath (HRD) and standing (HRS) and Valsalva tests...
July 29, 2016: Autonomic Neuroscience: Basic & Clinical
Jan Novak, Miroslav Souček
UNLABELLED: microRNAs (abbreviated miRNAs or miRs) represents one of the group of so called small non-coding RNAs which participate in the negative post-transcriptional regulation of gene expression. According to the base complementarity they target molecules of messenger RNAs (mRNAs) which results either in translational blockade or in degradation of target mRNA. One miRNA usually targets more mRNA and one mRNA is usually targeted by more than one miRNA - complicated and interconnected regulatory networks are thus created and their disruption leads to the abnormalities in development or results in the development of diseases...
2016: Vnitr̆ní Lékar̆ství
Tiina Ilves, Anu Virolainen, Ilkka Tapani Harvima
BACKGROUND: Sweating can worsen atopic dermatitis (AD). The purpose of this work was to study the associations between reactivity to autologous sweat and the clinical severity of AD as well as investigate the possible wheal-inducing factors of sweat. METHODS: Intracutaneous skin tests with autologous sweat were performed on 50 AD patients and 24 control subjects. In skin biopsies, tryptase and PAR-2 were enzyme and immunohistochemically stained. The associations between skin test reactivity and sweat histamine concentration, tryptase or chymase activity levels, tryptase or PAR-2 expression and AD clinical severity or IgE levels were investigated...
2016: International Archives of Allergy and Immunology
Mika Terao, Ichiro Katayama
Cortisol and corticosterone are the endogenous glucocorticoids (GCs) in humans and rodents, respectively. Systemic GC is released through the hypothalamic-pituitary-adrenal (HPA) axis in response to various stressors. Over the last decade, extra-adrenal production/activation of cortisol/corticosterone has been reported in many tissues. The enzyme that catalyzes the conversion of hormonally inactive cortisone/11-dehydrocorticosterone (11-DHC) into active cortisol/corticosterone in cells is 11β-hydroxysteroid dehydrogenase (11β-HSD)...
June 29, 2016: Journal of Dermatological Science
David A Low, Tom G Bailey, N Timothy Cable, Helen Jones
OBJECTIVE: The aim of this study was to examine the cutaneous vascular and sudomotor responses to combined moderate passive heat stress and normobaric hypoxia. METHOD: Thirteen healthy young males, dressed in a water-perfused suit, underwent passive heating (Δcore temperature ~0.7 °C) twice (NORMOXIA; 20.9% O2 and HYPOXIA; 13% O2 ). Chest and forearm skin blood flow (SkBF; laser Doppler flux), local sweat rate (SR; capacitance hygrometry) and core (intestinal pill) and skin temperatures, were recorded...
July 15, 2016: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
Zachary J Schlader, Gregory L Coleman, James R Sackett, Suman Sarker, Christopher L Chapman, Blair D Johnson
We tested the hypothesis that acute increases in metabolic heat production and sweating precede the initiation of thermoregulatory behavior in resting humans exposed to cool and warm environments. Twelve healthy young subjects passively moved between 17 °C and 40 °C rooms when they felt 'too cool' (C→W) or 'too warm' (W→C). Skin and internal (intestinal) temperatures, metabolic heat production, local sweat rate (forearm, chest), and cutaneous vascular conductance (CVC; forearm, fingertip) were measured continually...
July 12, 2016: Experimental Physiology
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