keyword
MENU ▼
Read by QxMD icon Read
search

Vancomycin pharmacokinetics

keyword
https://www.readbyqxmd.com/read/29780587/development-of-a-vancomycin-dosing-approach-for-critically-ill-patients-receiving-hybrid-hemodialysis-using-monte-carlo-simulation
#1
Susan J Lewis, Bruce A Mueller
Objectives: Prolonged intermittent renal replacement therapy is an increasingly popular treatment for acute kidney injury in critically ill patients that runs at different flow rates and durations than conventional hemodialysis or continuous renal replacement therapies. Pharmacokinetic studies conducted in patients receiving prolonged intermittent renal replacement therapy are scarce; consequently, clinicians are challenged to dose antibiotics effectively. The purpose of this study was to develop vancomycin dosing recommendations for patients receiving prolonged intermittent renal replacement therapy...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29773886/pretreatment-with-broad-spectrum-antibiotics-alters-the-pharmacokinetics-of-major-constituents-of-shaoyao-gancao-decoction-in-rats-after-oral-administration
#2
Meng Liu, Jie Yuan, Wen-Juan Hu, Chang-Qiang Ke, Yi-Fan Zhang, Yang Ye, Da-Fang Zhong, Guang-Rong Zhao, Sheng Yao, Jia Liu
The influence of broad-spectrum antibiotics on the pharmacokinetics and biotransformation of major constituents of Shaoyao-Gancao decoction (SGD) in rats was investigated. The pharmacokinetic behaviors of paeoniflorin (PF), albiflorin (AF), liquiritin (LT), isoliquiritin (ILT), liquiritin apioside (LA), isoliquiritin apioside (ILA), and glycyrrhizic acid (GL), seven major constituents of SGD, as well as glycyrrhetinic acid (GA), a major metabolite of GL, were analyzed. A 1-week pretreatment with broad-spectrum antibiotics (ampicillin, metronidazole, neomycin, 1 g L-1 ; and vancomycin, 0...
May 17, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29770901/factors-impacting-unbound-vancomycin-concentrations-in-neonates-and-young-infants
#3
Anne Smits, Steven Pauwels, Matthijs Oyaert, Nele Peersman, Isabel Spriet, Veroniek Saegeman, Karel Allegaert
Vancomycin pharmacokinetic (PK) and pharmacodynamic (PD) data in neonates are based on total concentrations. However, only unbound vancomycin is pharmacologically active. The objective was to determine vancomycin protein binding and the covariates impacting unbound vancomycin concentration in neonates and young infants. In neonates and young infants to whom vancomycin was administered intermittently for medical indications, total and unbound vancomycin plasma concentrations were determined using LC-MS/MS. Sampling occurred randomly during vancomycin exposure, covering a broad range of concentrations...
May 16, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29764549/-clinical-verification-of-vancomycin-population-pharmacokinetics-in-patients-with-augmented-renal-clearance
#4
Haodi Lu, Lian Tang, Shengmin Xue, Zhiwei Zhuang, Jie Fang, Fuli Zhao, Erning Shang
OBJECTIVE: To evaluate the predictive value and to verify the clinical effect of JPKD-vancomycin for the trough concentration of vancomycin in patients with augmented renal clearance (ARC), and to provide a reference for clinical individualized drug therapy. METHODS: A retrospective analysis was conducted. The clinical data of 48 adult patients with ARC using vancomycin and monitoring steady-state trough concentration of vancomycin admitted to Suzhou Hospital Affiliated to Nanjing Medical University from July 2013 to July 2017 were collected...
May 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29764190/delafloxacin-an-improved-fluoroquinolone-developed-through-advanced-molecular-engineering
#5
Matteo Bassetti, Elda Righi, Davide Pecori, Glenn Tillotson
The emergence of antimicrobial resistance threatens current clinical practice across a range of infection types. Delafloxacin, a non-zwitterionic fluoroquinolone recently approved by the US FDA for the treatment of acute bacterial skin and skin structure infections, has been developed to address some of these challenges. Uniquely delafloxacin has increased intracellular penetration and enhanced antibacterial activity under acidic conditions, an environment seen in many infection sites including abscesses. Delafloxacin is active against a wide range of Gram-positive and -negative species including methicillin-resistant Staphylococcus aureus and many fluoroquinolone-resistant strains...
May 16, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29762865/population-pharmacokinetics-of-vancomycin-in-patients-undergoing-allogeneic-hematopoietic-stem-cell-transplantation
#6
Akira Okada, Misato Kariya, Kei Irie, Yutaka Okada, Nobuhiro Hiramoto, Hisako Hashimoto, Ryosuke Kajioka, Chika Maruyama, Hidefumi Kasai, Mami Hamori, Asako Nishimura, Nobuhito Shibata, Keizo Fukushima, Nobuyuki Sugioka
Vancomycin is a commonly used antimicrobial agent for patients undergoing allogeneic hematopoietic stem-cell transplantation (allo-HSCT). Vancomycin has large inter- and intraindividual pharmacokinetic variability, which is mainly described by renal function; various studies have indicated that vancomycin pharmacokinetics are altered in special populations. However, little is known regarding vancomycin pharmacokinetics in patients undergoing allo-HSCT. Therefore, we aimed to develop a population pharmacokinetic (PopPK) model of vancomycin in patients undergoing allo-HSCT for effective and safe antimicrobial therapy and to develop a vancomycin dosing nomogram for a vancomycin optimal-dosing strategy...
May 15, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29742643/pharmacokinetic-monitoring-of-vancomycin-in-cystic-fibrosis-is-it-time-to-move-past-trough-concentrations
#7
Nicholas M Fusco, William A Prescott, Calvin J Meaney
BACKGROUND: A correlation between vancomycin trough concentrations (VTC) and area under the curve (AUC) to minimum inhibitory concentration (MIC) ratio (AUC/MIC) has not been established in children/adolescents with cystic fibrosis (CF). The primary objective of this study was to determine the correlation between measured VTCs and AUC/MIC using population-based pharmacokinetics. METHODS: A retrospective cohort study of children/adolescents diagnosed with CF, age 6 to < 18 years, treated with vancomycin (VAN) for methicillin-resistant Staphylococcus aureus (MRSA) infection was conducted...
May 4, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29736878/vancomycin-in-pediatric-patients-with-solid-or-hematological-malignant-disease-predictive-performance-of-a-population-pharmacokinetic-model-and-new-optimized-dosing-regimens
#8
Amélie Marsot, F Gallais, C Galambrun, C Coze, O Blin, N Andre, R Guilhaumou
BACKGROUND: The application of population pharmacokinetic models and Bayesian methods offers the potential to develop individualized therapeutic approaches. OBJECTIVES: The current study presents an external evaluation of a vancomycin pharmacokinetic model in a pediatric cancer population and proposes an easy-to-use chart for clinicians for a priori vancomycin schedule adaptation to achieve target concentration. METHODS: External evaluation of a population pharmacokinetic model of vancomycin administered via continuous infusion was realized in a new retrospective dataset of pediatric patients with cancer...
May 8, 2018: Paediatric Drugs
https://www.readbyqxmd.com/read/29720909/use-of-individual-pharmacokinetics-to-improve-time-to-therapeutic-vancomycin-trough-in-pediatric-oncology-patients
#9
Calvin L Miller, S Alexander Winans, John J Veillette, Steven C Forland
OBJECTIVE: Optimization of vancomycin dosing is difficult in children, given rapid drug clearance and patient heterogeneity. We sought to evaluate the impact of dosing using individual pharmacokinetic parameters on time to goal trough concentration in pediatric oncology patients. METHODS: A retrospective review was conducted to assess vancomycin dosing in the pediatric oncology unit at Loma Linda University Children's Hospital between January 2013 and August 2013 (standard dosing group [SDG])...
March 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29691260/ceftolozane-tazobactam-for-the-treatment-of-multidrug-resistant-pseudomonas-aeruginosa-pneumonia-in-a-patient-receiving-intermittent-hemodialysis
#10
Mohammed A Alessa, Thamer A Almangour, Abdulaziz Alhossan, Musaed A Alkholief, Mohammed Alhokail, Deanne E Tabb
PURPOSE: The safety and effectiveness of ceftolozane-tazobactam for the treatment of multidrug-resistant (MDR) Pseudomonas aeruginosa pneumonia in a patient receiving intermittent hemodialysis are reported. CASE REPORT: A 79-year-old African-American man arrived at an emergency trauma center from a nursing home via ambulance with shortness of breath and potential nasogastric tube misplacement. His medical history included end-stage renal disease (ESRD) for which he was receiving intermittent hemodialysis 3 times per week, hypertension, sacral ulcer, coronary artery bypass graft surgery, and P...
May 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29686154/population-pharmacokinetic-model-for-vancomycin-used-in-open-heart-surgery-model-based-evaluation-of-standard-dosing-regimens
#11
Saeed A Alqahtani, Abdullah S Alsultan, Hussain M Alqattan, Ahmed Eldemerdash, Turki B Albacker
The purpose of this study was to investigate the population pharmacokinetics of vancomycin in patients undergoing open heart surgery. In this observational pharmacokinetic study, multiple blood samples were drawn over a 48-h period of intravenous vancomycin in patients who were undergoing open heart surgery. Blood samples were analysed using the Architect i4000SR Immunoassay Analyzer. Population pharmacokinetic models were developed using Monolix 4.4 software. Pharmacokinetic-pharmacodynamic (PK-PD) simulations were performed to explore the ability of different dosage regimens to achieve the pharmacodynamic targets...
April 23, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29670380/emerging-treatment-options-for-acute-bacterial-skin-and-skin-structure-infections-focus-on-intravenous-delafloxacin
#12
REVIEW
Elda Righi, Alessia Carnelutti, Antonio Vena, Matteo Bassetti
The increase in hospitalization due to acute bacterial skin and skin structure infections (ABSSSI) caused by resistant pathogens supports the need for new treatment options. Antimicrobial options for ABSSSI that provide broad-spectrum coverage, including gram-negative pathogens and multidrug-resistant gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), are limited. Delafloxacin is a novel fluoroquinolone available as intravenous and oral formulations and is characterized by an increased efficacy in acidic environments and activity on bacterial biofilm...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29652968/-therapeutic-monitoring-of-antimicrobial-agents-in-pediatrics-review-based-on-latin-american-experiences
#13
Brenda Zylbersztajn, Marlon Barraza, Juan P Torres, Jorge Morales
This review summarizes recommendations of therapeutic monitoring of three antimicrobials based in regional data: vancomycin, amikacin and voriconazole in pediatric population. Regional evidence agrees with international literature regarding the requirement of higher daily doses than 40 mg/kg/day of vancomycin, as well as with the possibility of use one daily doses of amikacin and to recommend higher doses of voriconazole compared to the initially recommended doses of 8 mg/kg/day. Local data on the pharmacokinetic/pharmacodynamic behavior of various antimicrobials in pediatrics are of great value for dosing adjustment in our pediatric population...
2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29651827/influence-of-pharmacokinetic-pharmacodynamic-ratio-on-vancomycin-treatment-response-in-paediatric-patients-with-staphylococcus-aureus-bacteremia
#14
Jesus Ruiz, Ana García-Robles, María R Marqués, Maria J Company, Antonio Solana, Jose L Poveda
BACKGROUND: Staphylococcus aureus is a frequent cause of hospital-acquired bacteremia in paediatrics patients. Vancomycin is the drug of choice for the treatment of methicillin-resistant strains, although treatment failure is frequently observed. Area under the curve (AUC) of plasma concentrations over the minimum inhibitory concentration (MIC) has been proposed as the best index to predict treatment response, although information about its clinical impact on paediatric patients is scarce...
April 12, 2018: Minerva Pediatrica
https://www.readbyqxmd.com/read/29615159/antimicrobial-stewardship-in-neonates-challenges-and-opportunities
#15
Christopher McPherson, Caren Liviskie, Brandy Zeller, Miranda P Nelson, Jason G Newland
Neonatal infections result in significant morbidity and mortality. Antibiotics are vital for the treatment of infections but disrupt the neonatal microbiome, put the infant at risk for an adverse drug reaction, and may lead to the development of antibiotic resistance. Immediately after birth, clinicians must determine which infants require empiric antibiotics. Online risk stratification tools may provide a superior approach to decision trees. In infants who require empiric therapy for early-onset sepsis, ampicillin and an aminoglycoside with dosing based on recent pharmacokinetic studies represents the most appropriate first-line agents; third-generation cephalosporins should be reserved for patients with a high likelihood of Gram-negative meningitis...
March 1, 2018: Neonatal Network: NN
https://www.readbyqxmd.com/read/29610194/the-combination-of-daptomycin-plus-fosfomycin-has-synergistic-potent-and-rapid-bactericidal-activity-against-methicillin-resistant-staphylococcus-aureus-mrsa-in-a-rabbit-model-of-experimental-endocarditis-ee
#16
Cristina García-de-la-Mària, Oriol Gasch, Javier García-Gonzalez, Dolors Soy, Evelyn Shaw, Juan Ambrosioni, Manel Almela, Juan M Pericàs, Adrián Tellez, Carlos Falces, Marta Hernandez-Meneses, Elena Sandoval, Eduard Quintana, Barbara Vidal, Jose M Tolosana, David Fuster, Jaume Llopis, Miquel Pujol, Asuncion Moreno, Francesc Marco, Jose M Miró
This study aims to investigate whether the addition of fosfomycin or cloxacillin to daptomycin provides better outcomes in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) experimental aortic endocarditis in rabbits. Five MRSA strains were used to perform in vitro time-kill studies at standard (105) and high (108) inocula. Combined therapy was compared with daptomycin monotherapy treatment in the MRSA experimental endocarditis model. A human-like pharmacokinetics model was applied and the equivalents of cloxacillin 2g/4hiv, fosfomycin 2g/6h iv and daptomycin 6-10mg/kg/d iv were administered...
April 2, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29605146/principles-and-applications-of-pharmacometrics-in-drug-evaluation-in-children
#17
Stéphanie Leroux, Valéry Elie, Wei Zhao, Sophie Magreault, Evelyne Jacqz-Aigrain
Drug evaluation in children is difficult for many well-identified reasons and many drugs are still used off-label. Innovative approaches are particularly adapted to the paediatric and neonatal populations, as clinical trials are difficult to conduct, need adapted designs in order to define the optimal dosage regimen in many diseases and therapeutic areas. Population approaches to define pharmacokinetics and pharmacokinetic/pharmacodynamics are now more currently used to define dosing regimens, adapted to the different paediatric and neonatal age groups, that allow to increase efficacy and reduce toxicity, by taking into account factors explaining variability in drug response...
February 16, 2018: Thérapie
https://www.readbyqxmd.com/read/29602981/population-pharmacokinetics-of-vancomycin-and-auc-guided-dosing-in-chinese-neonates-and-young-infants
#18
Yewei Chen, Dan Wu, Min Dong, Yiqing Zhu, Jinmiao Lu, Xiaoxia Li, Chao Chen, Zhiping Li
OBJECTIVES: To develop a population pharmacokinetic (PK) model for vancomycin in Chinese neonates and infants less than 2 months of age (young infants) with a wide gestational age range, in order to determine the appropriate dosing regimen for this population. METHODS: We performed a retrospective chart review of patients from the neonatal intensive care unit (NICU) at Children's Hospital of Fudan University to identify neonates and young infants treated with vancomycin from May 2014 to May 2017...
March 30, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29561305/exploring-the-use-of-c-reactive-protein-to-estimate-the-pharmacodynamics-of-vancomycin
#19
Timothy M Rawson, Esmita Charani, Luke Sp Moore, Mark Gilchrist, Pantelis Georgiou, William Hope, Alison H Holmes
BackgroundC-reactive protein (CRP) pharmacodynamic (PD) models have the potential to provide adjunctive methods for predicting the individual exposure-response to antimicrobial therapy. We investigated CRP PD linked to a vancomycin pharmacokinetics (PK) model using routinely collected data from non-critical care adults in secondary care.MethodsPatients receiving intermittent intravenous vancomycin therapy in secondary care were identified. A two-compartment vancomycin PK model was linked to a previously described PD model describing CRP response...
March 20, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29526606/population-pharmacokinetics-of-vancomycin-in-critically-ill-patients-receiving-prolonged-intermittent-renal-replacement-therapy
#20
Caleb J P Economou, Jan T Kielstein, David Czock, Jiao Xie, Jonathan Field, Brent Richards, Mandy Tallot, Adam Visser, Christina Koenig, Carsten Hafer, Julius J Schmidt, Jeffrey Lipman, Jason A Roberts
OBJECTIVES: The aim of this study was to describe the population pharmacokinetics of vancomycin during prolonged intermittent renal replacement therapy (PIRRT) in critically ill patients with acute kidney injury. METHODS: Critically ill patients prescribed vancomycin across two sites had blood samples collected during 1-3 dosing intervals during which PIRRT was performed. Plasma samples were assayed with a validated immunoassay method. Population pharmacokinetic analysis and Monte Carlo simulations were performed using Pmetrics® ...
March 8, 2018: International Journal of Antimicrobial Agents
keyword
keyword
26341
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"