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https://www.readbyqxmd.com/read/29240799/inappropriate-self-medication-among-adolescents-and-its-association-with-lower-medication-literacy-and-substance-use
#1
Chun-Hsien Lee, Fong-Ching Chang, Sheng-Der Hsu, Hsueh-Yun Chi, Li-Jung Huang, Ming-Kung Yeh
BACKGROUND: While self-medication is common, inappropriate self-medication has potential risks. This study assesses inappropriate self-medication among adolescents and examines the relationships among medication literacy, substance use, and inappropriate self-medication. METHOD: In 2016, a national representative sample of 6,226 students from 99 primary, middle, and high schools completed an online self-administered questionnaire. Multiple logistic regression analysis was used to examine factors related to inappropriate self-medication...
2017: PloS One
https://www.readbyqxmd.com/read/29235038/simple-approach-for-de-novo-structural-identification-of-mannose-trisaccharides
#2
Hsu Chen Hsu, Chia Yen Liew, Shih-Pei Huang, Shang-Ting Tsai, Chi-Kung Ni
Oligosaccharides have diverse functions in biological systems. However, the structural determination of oligosaccharides remains difficult and has created a bottleneck in carbohydrate research. In this study, a new approach for the de novo structural determination of underivatized oligosaccharides is demonstrated. A low-energy collision-induced dissociation (CID) of sodium ion adducts was used to facilitate the cleavage of desired chemical bonds during the dissociation. The selection of fragments for the subsequent CID was guided using a procedure that we built from the understanding of the saccharide dissociation mechanism...
December 12, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29207018/clinical-significance-of-interleukin%C3%A2-6-and-inducible-nitric-oxide-synthase-in-ketamine%C3%A2-induced-cystitis
#3
Chi-Jung Huang, Fa-Kung Lee, Shao-Kuan Chen, Chih-Cheng Chien, Sheng-Tang Wu, Yen-Chieh Wang
Ketamine is an ionotropic glutamatergic N‑methyl‑D‑aspartate receptor antagonist, which is widely used among recreational drug abusers. Ketamine abusers exhibit substantially reduced bladder capacity, which can lead to urinary frequency. The molecular pathogenesis of ketamine‑induced cystitis has been scarcely reported. Given previous clinical findings, it may be hypothesized that pathological alterations in smooth muscle cells (SMCs) of the urinary bladder serve a crucial role in the mechanism underlying cystitis...
November 17, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29182404/evaluation-of-the-effect-of-everolimus-on-retinal-pigment-epithelial-cells-and-experimental-proliferative-vitreoretinopathy
#4
Hsi-Kung Kuo, Yi-Hao Chen, Yu-Hsia Kuo, Mu-Chan Ke, Ya-Chi Tseng, Pei-Chang Wu
PURPOSE: Failure of retinal detachment surgery is most commonly due to the development of proliferative vitreoretinopathy (PVR). Everolimus is an inhibitor of mammalian target of rapamycin (mTOR), and is available as oral tablets. In this study, we investigated the effect of everolimus on retinal pigment epithelial cells and modification of the severity of experimental PVR. METHODS: In our in vitro studies, primary culture of retinal pigment epithelium (RPE) cells was obtained from pigmented Rex rabbits...
November 28, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29180361/production-of-1-dodecanol-1-tetradecanol-and-1-12-dodecanediol-by-whole-cell-biotransformation-in-escherichia-coli
#5
Shan-Chi Hsieh, Jung-Hao Wang, Yu-Chen Lai, Ching-Yeuh Su, Kung-Ta Lee
Medium- and long-chain 1-alkanol and α,ω-alkanediols are used in personal care products, industrial lubricants, and as precursors for polymers synthesized for medical applications. The industrial production of α,ω-alkanediols by alkane hydroxylation primarily occurs at a high temperature and pressure using heavy metal catalysts. However, bio-production has recently emerged as a more economically and environmentally friendly alternative. Among alkane monooxygenases, CYP153A from Marinobacter aquaeolei VT8 possesses low overoxidation activity and high regioselectivity and thus has great potential for use in terminal hydroxylation...
November 27, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29168286/comparative-proteomic-profiling-reveals-a-role-for-cisd2-in-skeletal-muscle-aging
#6
Yi-Long Huang, Zhao-Qing Shen, Chia-Yu Wu, Yuan-Chi Teng, Chen-Chung Liao, Cheng-Heng Kao, Liang-Kung Chen, Chao-Hsiung Lin, Ting-Fen Tsai
Skeletal muscle has emerged as one of the most important tissues involved in regulating systemic metabolism. The gastrocnemius is a powerful skeletal muscle composed of predominantly glycolytic fast-twitch fibers that are preferentially lost among old age. This decrease in gastrocnemius muscle mass is remarkable during aging; however, the underlying molecular mechanism is not fully understood. Strikingly, there is a ~70% decrease in Cisd2 protein, a key regulator of lifespan in mice and the disease gene for Wolfram syndrome 2 in humans, within the gastrocnemius after middle age among mice...
November 23, 2017: Aging Cell
https://www.readbyqxmd.com/read/29137263/melatonin-suppresses-hepatocellular-carcinoma-progression-via-lncrna-cps1-it-mediated-hif-1%C3%AE-inactivation
#7
Tong-Hong Wang, Chi-Hao Wu, Chau-Ting Yeh, Shih-Chi Su, Shih-Min Hsia, Kung-Hao Liang, Chin-Chuan Chen, Chuen Hsueh, Chi-Yuan Chen
Melatonin is the primary pineal hormone that relays light/dark cycle information to the circadian system. It was recently reported to exert intrinsic antitumor activity in various cancers. However, the regulatory mechanisms underlying the antitumor activity of melatonin are poorly understood. Moreover, a limited number of studies have addressed the role of melatonin in hepatocellular carcinoma (HCC), a major life-threatening malignancy in both sexes in Taiwan. In this study, we investigated the antitumor effects of melatonin in HCC and explored the regulatory mechanisms underlying these effects...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29114176/detecting-triple-vessel-disease-with-cadmium-zinc-telluride-based-single-photon-emission-computed-tomography-using-the-intensity-signal-to-noise-ratio-between-rest-and-stress-studies
#8
Yu-Hua Dean Fang, Tzu-Pei Su, Chi-Jen Chang, Kung-Chu Ho, May Su, Tzu-Chen Yen
The purpose of this study was to investigate if a novel parameter, the stress-to-rest ratio of the signal-to-noise ratio (RSNR) obtained with a cadmium zinc telluride (CZT) SPECT scanner, could be used to distinguish triple-vessel disease (TVD) patients. Methods. One hundred and two patients with suspected coronary artery disease were retrospectively involved. Each subject underwent a Tl-201 SPECT scan and subsequent coronary angiography. Subjects were separated into TVD (n = 41) and control (n = 61) groups based on coronary angiography results using 50% as the stenosis cutoff...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29104465/effect-of-coriolus-versicolor-mycelia-extract-on-exercise-performance-and-physical-fatigue-in-mice
#9
Chun-Sheng Ho, Yu-Tang Tung, Woon-Man Kung, Wen-Ching Huang, Wing-Ki Leung, Chi-Chang Huang, Jyh-Horng Wu
In this study, Coriolus versicolor mycelia (CVM) was evaluated the ergogenic and anti-fatigue activities. Male ICR mice were divided into four groups (n = 8/group) to receive vehicle or CVM by oral gavage for 4 weeks at 0, 615, 1230 or 3075 mg/kg/day, which were respectively designated the vehicle, CVM-1X, CVM-2X and CVM-5X groups. Forelimb grip strength, endurance swimming time, and levels of physical fatigue-associated parameters serum lactate, ammonia, glucose and creatine kinase (CK) after physical challenge were performed to evaluate exercise performance and anti-fatigue activity...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29100283/circulating-microparticles-are-prognostic-biomarkers-in-advanced-non-small-cell-lung-cancer-patients
#10
Chin-Chou Wang, Chia-Cheng Tseng, Huang-Chih Chang, Kuo-Tung Huang, Wen-Feng Fang, Yu-Mu Chen, Cheng-Ta Yang, Chang-Chun Hsiao, Meng-Chih Lin, Chi-Kung Ho, Hon-Kan Yip
We investigated whether circulating microparticles (MPs) could serve as prognostic biomarkers in non-small cell lung cancer (NSCLC) patients. We enrolled 25 control subjects and 136 NSCLC patients categorized into disease-progression (DP, n=42) and disease-control (DC, n=94) groups. Flow cytometric analysis showed that levels of four types of circulating microparticles (EDAc-MPs, EDAp-MPs, PDAc-MPs and PDAp-MPs) were higher in the study patients than the control subjects (P < 0.04). DP patients showed poor initially performance status and more non-adenocarcinomas than DC patients...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098808/casticin-impairs-cell-growth-and-induces-cell-apoptosis-via-cell-cycle-arrest-in-human-oral-cancer-scc-4-cells
#11
Guan-Ling Chou, Shu-Fen Peng, Ching-Lung Liao, Heng-Chien Ho, Kung-Wen Lu, Jin-Cherng Lien, Ming-Jen Fan, Kuang-Chi La, Jing-Gung Chung
Casticin, a polymethoxyflavone, present in natural plants, has been shown to have biological activities including anti-cancer activities. Herein, we investigated the anti-oral cancer activity of casticin on SCC-4 cells in vitro. Viable cells, cell cycle distribution, apoptotic cell death, reactive oxygen species (ROS) production, and Ca(2+) production, levels of ΔΨm and caspase activity were measured by flow cytometric assay. Cell apoptosis associated protein expressions were examined by Western blotting and confocal laser microscopy...
November 3, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29028684/toxic-metals-increase-serum-tumor-necrosis-factor-%C3%AE-levels-modified-by-essential-elements-and-different-types-of-tumor-necrosis-factor-%C3%AE-promoter-single-nucleotide-polymorphisms
#12
Yung-Cheng Huang, Wei-Chiao Chang, Ya-Han Shan, Chao-Yi Lin, Chao-Ling Wang, Chia-Yen Dai, Chi-Kung Ho, Ming-Tsang Wu, Hung-Yi Chuang
BACKGROUND: Lead (Pb), cadmium (Cd), and arsenic (As) could cause health issues through oxidative stress that is indicated in the elevated tumor necrosis factor-alpha (TNF-α). However, some of the essential elements-selenium (Se), zinc (Zn), cobalt (Co), and copper (Cu)-are cofactors or structural components of antioxidant enzymes. It is suggested that single-nucleotide polymorphisms (SNPs) in the TNF-α gene have different TNF-α responses. This study aims to evaluate the effect of serum TNF-α levels through the interactions between toxic metals and essential elements and how the interactions between the toxic metals and TNF-α SNPs (-1031 T > C, -863 C > A, -857 C > T, -308 G > A, -238 G > A) influence serum TNF-α levels...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/28993442/in-room-assessment-of-intravascular-velocity-from-time-resolved-rotational-angiography-in-patients-with-arteriovenous-malformation-a-pilot-study
#13
Chung Jung Lin, Huai Che Yang, Ai Chi Chien, Wan Yuo Guo, Chih Chun Wu, Sheng Che Hung, Ko Kung Chen, Hsiu Mei Wu, Chao Bao Luo, Wei Fa Chu, Jia Sheng Hong, Chun Shien Frank Wu
BACKGROUND: Time-resolved rotational angiography (t-RA) enables interventionists to better comprehend complex arteriovenous malformations (AVMs), thereby facilitating endovascular treatment. However, its use in evaluating hemodynamic changes has rarely been explored. OBJECTIVE: This study uses t-RA to estimate intravascular flow in patients with AVM to compare this with flow in the normal population. METHODS: Patients with available t-RA scans were prospectively categorized into one of three groups: hemorrhagic AVM, non-hemorrhagic AVM and control...
October 9, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28988665/the-epidemiology-of-non-typhoidal-salmonella-gastroenteritis-and-campylobacter-gastroenteritis-in-pediatric-inpatients-in-northern-taiwan
#14
Chien-Fang Tseng, Nan-Chang Chiu, Ching-Ying Huang, Daniel Tsung-Ning Huang, Lung Chang, Yen-Hsin Kung, Fu-Yuan Huang, Hsin Chi
BACKGROUND: Campylobacter and Non-typhoidal Salmonella (NTS) are the two most common bacterial pathogens associated with acute gastroenteritis in children. This study aims to elucidate the epidemiology of Campylobacter and NTS gastroenteritis and develop a scoring system to differentiate them. MATERIALS AND METHODS: This retrospective study enrolled 886 children ≤18 years of age, hospitalized due to acute gastroenteritis with stool culture-proven Campylobacter or NTS infection from July 2012 to December 2015...
September 27, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28988664/epidemiology-and-antimicrobial-susceptibility-of-non-typeable-haemophilus-influenzae-in-otitis-media-in-taiwanese-children
#15
Ying-Chun Cho, Nan-Chang Chiu, Fu-Yuan Huang, Daniel Tsung-Ning Huang, Lung Chang, Ching-Ying Huang, Yen-Hsin Kung, Kuo-Sheng Lee, Hsin Chi
BACKGROUND: Concerns about non-typeable Haemophilus influenzae (NTHi) in otitis media (OM) have grown after the introduction of pneumococcal conjugate vaccine (PCV). We aim to better understand the clinical role of NTHi in pediatric OM. METHODS: Middle ear fluid samples from children <18 years with OM were obtained from 2010 to 2015. For culture-positive episodes (Streptococcus pneumoniae, H. influenzae, Moraxella catarrhalis, and Streptococcus pyogenes), patients' demographic and clinical information were reviewed and analyzed...
September 18, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28985720/effects-of-homocysteine-on-white-matter-diffusion-parameters-in-alzheimer-s-disease
#16
Chen-Chang Lee, Shih-Wei Hsu, Chi-Wei Huang, Wen-Neng Chang, Sz-Fan Chen, Ming-Kung Wu, Chiung-Chih Chang, Lain-Chyr Hwang, Po-Chou Chen
BACKGROUND: The clinical features of Alzheimer's disease (AD) are related to brain network degeneration, and hyperhomocysteinemia is related to greater white matter hyperintensities. We investigated the changes in four diffusion tensor imaging parameters in the white matter of patients with early stage AD, examined their associations with homocysteine level, and tested the clinical significance of the diffusion tensor imaging parameters and homocysteine level in correlation analysis with cognitive test scores...
October 6, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28983679/safety-of-omitting-routine-bleeding-tests-prior-to-image-guided-musculoskeletal-core-needle-biopsy
#17
Yuri Shif, Justin W Kung, Colm J McMahon, Jennifer Ni Mhuircheartaigh, Yu Ching Lin, Megan E Anderson, Jim S Wu
PURPOSE: To evaluate the safety of withholding preprocedure international normalized ratio (INR) and platelet testing in patients undergoing musculoskeletal (MSK) core needle biopsy (CNB). MATERIAL AND METHODS: Initially, a retrospective review of 1,162 consecutive patients undergoing MSK CNB with preprocedural INR and platelet testing was performed. Clinical (age, gender, bleeding disorder, liver disease, anticoagulation use, INR > 2, platelet count <50,000/ul) and biopsy factors (imaging modality, lesion type, biopsy needle gauge, number biopsy samples) were tested for association with bleeding complications...
October 6, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28974646/factors-associated-with-re-intubation-within-14-days-after-ventilator-liberation
#18
Chia-Chen Chu, Chin-Jung Liu, Suh-May Yen, Wen-Yu Chou, Pei-Tseng Kung, Yuh-Show Tsai, Wen-Chen Tsai
BACKGROUND: According to Taiwan's integrated delivery system policy, ventilator-dependent patients are successfully liberated from mechanical ventilation in accordance with step-down care. However, premature discharge affects the 14-d readmission quality index. Therefore, we explored the risk and related factors of subjects liberated from mechanical ventilation who were re-intubated within 14 d. METHODS: This retrospective study analyzed a cohort of ventilator-dependent subjects 17 y of age and older using a population-based database from the Taiwan National Health Research Institutes Database from 2006 to 2010...
December 2017: Respiratory Care
https://www.readbyqxmd.com/read/28950692/effect-of-carvacrol-on-ca%C3%A2-%C3%A2-%C2%BA-movement-and-viability-in-pc3-human-prostate-cancer-cells
#19
Chi-Ting Horng, Chiang-Ting Chou, Te-Kung Sun, Wei-Zhe Liang, Chun-Chi Kuo, Jue-Long Wang, Pochuen Shieh, Chung-Ren Jan
Carvacrol, a monoterpenic phenol compound, has been shown to possess various biological effects in different models. However, the effect of carvacrol on intracellular Ca²⁺ and its related physiology in human prostate cancer is unknown. This study explored the effect of carvacrol on cytosolic free Ca²⁺ levels ([Ca²⁺]i) and viability in PC3 human prostate cancer cells. Fura-2, a Ca²⁺- sensitive fluorescent dye, was used to assess [Ca²⁺]i. Cell viability was measured by the detecting reagent WST-1...
October 31, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/28943959/cyclin-d1-overexpression-correlates-with-poor-tumor-differentiation-and-prognosis-in-gastric-cancer
#20
Yan-Shen Shan, Hui-Ping Hsu, Ming-Derg Lai, Yu-Hsuan Hung, Chih-Yang Wang, Meng-Chi Yen, Yi-Ling Chen
Overexpression of cyclin D is associated with the molecular tumorigenesis of gastric cancer. The purpose of the present study was to investigate the expression of cyclin D in human gastric cancer and to determine the potential correlations between cyclin D expression and clinicopathological characteristics of specific histological types, as well as its prognostic significance. In the present study, the expression of the cyclin D1 (CCND1), cyclin D2 (CCND2) and cyclin D3 (CCND3) genes in gastric cancer patients was explored using the Oncomine database, and their correlation with overall survival (OS) and progression-free survival (PFS) was evaluated using Kaplan-Meier analysis...
October 2017: Oncology Letters
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