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https://www.readbyqxmd.com/read/28812143/serotonin-in-psychiatry-in-vitro-disease-modeling-using-patient-derived-neurons
#1
REVIEW
Krishna C Vadodaria, Shani Stern, Maria C Marchetto, Fred H Gage
Several lines of evidence implicate serotonin in the etiology of multiple psychiatric disorders, especially mood disorders, such as major depressive disorder (MDD) and bipolar disorder (BD). Much of our current understanding of biological mechanisms underlying serotonergic alterations in mood disorders comes from animal studies. Innovation in induced pluripotent stem cell and transdifferentiation technologies for deriving neurons from adult humans has enabled the study of disease-relevant cellular phenotypes in vitro...
August 15, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28811941/seizure-associated-takotsubo-syndrome-a-rare-combination
#2
Htay Htay Kyi, Nour Aljariri Alhesan, Sunil Upadhaya, Samer Al Hadidi
Takotsubo cardiomyopathy (TC) is increasingly recognized in neurocritical care population especially in postmenopausal females. We are presenting a 61-year-old African American female with past medical history of epilepsy, bipolar disorder, and hypertension who presented with multiple episodes of seizures due to noncompliance with antiepileptic medications. She was on telemetry which showed ST alarm. Electrocardiogram (ECG) was ordered and showed ST elevation in anterolateral leads and troponins were positive...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28811917/drug-information-update-lithium-and-chronic-kidney-disease-debates-and-dilemmas
#3
Sumeet Gupta, Udayan Khastgir
Lithium is an established treatment for bipolar disorder and an augmenting agent for treatment-resistant depression. Despite awareness of renal adverse effects, including chronic kidney disease, for the past five decades, there has been a lack of research evidence. This has led to debates around the existence and magnitude of the risk. This article discusses the current evidence base regarding the link between lithium and chronic kidney disease, monitoring of renal functions and its clinical implications.
August 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/28811911/evaluation-of-the-13-item-hypomania-checklist-and-a-brief-3-item-manic-features-questionnaire-in-primary-care
#4
Sukhmeet Singh, Paul Scouller, Daniel J Smith
Aims and method The mean delay for bipolar disorder diagnosis is 10 years. Identification of patients with previous hypomania is challenging, sometimes resulting in misdiagnosis. The aims of this study were: (a) to estimate the proportion of primary care patients with depression currently taking antidepressants who have undiagnosed bipolar disorder and (b) to compare a brief 3-item manic features questionnaire with the Hypomania Checklist (HCL-13). The sample comprised patients with a recorded diagnosis of depression, either on long-term antidepressant therapy or with previous multiple courses of antidepressants...
August 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/28810176/influence-of-gender-on-inpatient-treatment-for-bipolar-disorder-an-analysis-of-60-607-hospitalisations
#5
Matthäus Fellinger, Thomas Waldhör, Victor Blüml, Nolan Williams, Benjamin Vyssoki
BACKGROUND: The influence of gender on inpatient treatment patterns in bipolar patients is unclear. The aim of this study is to examine whether differences in length of stay and frequency of inpatient episodes, according to ICD-10 bipolar disorder (BD)-subgroups, exist between men and women. METHODS: All episodes of a manic (F31.0-2), depressive (F31.3-5) or mixed (F31.6) subtype of BD during an inpatient stay in an Austrian hospital in the period of 2001-2014 were included in this study...
August 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28809856/decreased-nox2-expression-in-the-brain-of-patients-with-bipolar-disorder-association-with-valproic-acid-prescription-and-substance-abuse
#6
T Seredenina, S Sorce, F R Herrmann, X-J Ma Mulone, O Plastre, A Aguzzi, V Jaquet, K-H Krause
Neuroinflammation and increased oxidative stress are believed to contribute to the development of psychiatric diseases. Animal studies have implicated NADPH oxidases (NOX) as relevant sources of reactive oxygen species in the brain. We have analyzed the expression of NOX isoforms in post-mortem brain samples from patients with psychiatric disorders (schizophrenia, bipolar disorder) and non-psychiatric subjects. Two collections from the Stanley Medical Research Institute were studied: the Array Collection (RNA, 35 individuals per group), and a neuropathology consortium collection (paraffin-embedded sections, 15 individuals per group)...
August 15, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28809398/precision-medicine-for-suicidality-from-universality-to-subtypes-and-personalization
#7
A B Niculescu, H Le-Niculescu, D F Levey, P L Phalen, H L Dainton, K Roseberry, E M Niculescu, J O Niezer, A Williams, D L Graham, T J Jones, V Venugopal, A Ballew, M Yard, T Gelbart, S M Kurian, A Shekhar, N J Schork, G E Sandusky, D R Salomon
Suicide remains a clear, present and increasing public health problem, despite being a potentially preventable tragedy. Its incidence is particularly high in people with overt or un(der)diagnosed psychiatric disorders. Objective and precise identification of individuals at risk, ways of monitoring response to treatments and novel preventive therapeutics need to be discovered, employed and widely deployed. We sought to investigate whether blood gene expression biomarkers for suicide (that is, a 'liquid biopsy' approach) can be identified that are more universal in nature, working across psychiatric diagnoses and genders, using larger cohorts than in previous studies...
August 15, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28808477/effect-of-lamotrigine-in-the-treatment-of-bipolar-depression-with-psychotic-features-a-case-report
#8
Tomoko Kajiya, Hiroko Sugawara, Yusuke Kajio, Satoru Morieda, Hibiki Tanaka, Tadashi Jono, Noboru Fujise, Mamoru Hashimoto
BACKGROUND: Major depressive episodes with psychotic features are more common in bipolar disorder than in major depressive disorder; however, there is little information on the optimal treatment for bipolar depression with psychotic features. CASE PRESENTATION: The patient was a 69-year-old man. At the age of 66, he was admitted to the hospital for the treatment of bipolar depression with psychotic features. He was treated with a combination therapy of antipsychotics and antidepressants during long-term hospitalization...
2017: Annals of General Psychiatry
https://www.readbyqxmd.com/read/28806578/klotho-dysfunction-a-pathway-linking-the-aging-process-to-bipolar-disorder
#9
Izabela Guimarães Barbosa, Natalia Pessoa Rocha, Gokay Alpak, Erica Leandro Marciano Vieira, Rodrigo Barreto Huguet, Fabio Lopes Rocha, Breno Satler de Oliveira Diniz, Antonio Lucio Teixeira
AIM: Although accelerated aging profile has been described in bipolar disorder (BD), the biology linking BD and aging is still largely unknown. Reduced levels and/or activity of a protein named Klotho is associated with decreased life span, premature aging and occurrence of age-related diseases. Therefore, this study was designed to evaluate plasma levels of Klotho in BD patients and controls. METHODS: Forty patients with type 1 BD and 30 controls were enrolled in this study...
August 11, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28806363/clinical-epidemiology-of-single-versus-multiple-substance-use-disorders-polysubstance-use-disorder
#10
Ish P Bhalla, Elina A Stefanovics, Robert A Rosenheck
OBJECTIVE: While research on substance abuse has largely focused on people who have a single substance use disorder (SUD), many people abuse multiple substances. Studies have yet to examine the distinctive characteristics of patients diagnosed with more than 1 SUD and how those with polysubstance use disorder (PSUD) differ from those with a single SUD. METHODS: National Veterans Health Administration data from fiscal year 2012 were used to compare veterans diagnosed 1 SUD to veterans diagnosed with 2-3, and >3 SUDs on demographic characteristics, psychiatric and medical diagnoses, medical and psychiatric service utilization, and psychotropic medication fills...
September 2017: Medical Care
https://www.readbyqxmd.com/read/28805813/analysis-of-genome-wide-association-data-highlights-candidates-for-drug-repositioning-in-psychiatry
#11
Hon-Cheong So, Carlos Kwan-Long Chau, Wan-To Chiu, Kin-Sang Ho, Cho-Pong Lo, Stephanie Ho-Yue Yim, Pak-Chung Sham
Knowledge of psychiatric disease genetics has advanced rapidly during the past decade with the advent of genome-wide association studies (GWAS). However, less progress has been made in harnessing these data to reveal new therapies. Here we propose a framework for drug repositioning by comparing transcriptomes imputed from GWAS data with drug-induced gene expression profiles from the Connectivity Map database and apply this approach to seven psychiatric disorders. We found a number of repositioning candidates, many supported by preclinical or clinical evidence...
August 14, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28805697/multiple-sclerosis-and-schizophrenia
#12
REVIEW
Borros M Arneth
The psychiatric and neurological aspects of health may present methodological challenges in the diagnosis and treatment of disease. This is especially true for patients whose symptoms indicate the coexistence of multiple sclerosis (MS) and schizophrenia (SCZ). These cases raise critical questions regarding the relationship between the mind and the brain. Studies have noted that patients with MS have an increased risk of developing SCZ or bipolar disorder (BD). It is suggested here that MS and a subgroup of SCZ have similar etiologies...
August 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28804990/characterizing-the-experience-of-auditory-verbal-hallucinations-and-accompanying-delusions-in-individuals-with-a-diagnosis-of-bipolar-disorder-a-systematic-review
#13
REVIEW
L M Smith, L C Johns, Rlc Mitchell
OBJECTIVES: The aim of the current study was to inform ongoing attempts to identify clinically meaningful subcategories of auditory verbal hallucination (AVH), and to evaluate evidence that might pertain to the suitability of current psychological interventions for people with bipolar disorder (BD) who experience psychotic symptoms. METHODS: A comprehensive synthesis of findings on the phenomenology of AVH and delusions in BD is included, alongside a critical review of clinical and cognitive correlates...
August 14, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28803680/corrigendum-to-analysis-of-association-between-common-snps-in-erbb4-and-bipolar-affective-disorder-major-depressive-disorder-and-schizophrenia-in-the-han-chinese-population-prog-neuro-psychopharmacol-biol-psychiatry-36-2012-17-21
#14
P Chen, J Chen, K Huang, W Ji, T Wang, T Li, Y Wang, H Wang, L He, G Feng, Y Shi
No abstract text is available yet for this article.
August 10, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28803247/potential-gender-related-aging-processes-occur-earlier-and-faster-in-the-vermis-of-patients-with-bipolar-disorder-an-mri-study
#15
Marta Serati, Giuseppe Delvecchio, Giulia Orsenigo, Cinzia Perlini, Marco Barillari, Mirella Ruggeri, Alfredo Carlo Altamura, Marcella Bellani, Paolo Brambilla
BACKGROUND: In the last decades, there has been increasing interest in investigating the role of the vermis in bipolar disorder (BD), especially because of its involvement in cognitive processes. The main aims of this study were to explore the integrity of the vermis and elucidate the role of demographic and clinical variables on vermis volumes in BD patients, stratified according to gender. METHODS: T1-weighted images were obtained for 38 BD patients and 38 healthy controls using a 1...
August 12, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28803094/brief-psychoeducation-for-bipolar-disorder-evaluation-of-trophic-factors-serum-levels-in-young-adults
#16
Carolina David Wiener, Mariane Lopez Molina, Fernanda Pedrotti Moreira, Miguel Bezerra Dos Passos, Karen Jansen, Ricardo Azevedo da Silva, Luciano Dias de Mattos Souza, Jean Pierre Oses
The aim of this study was to evaluate the impact of psychoeducation in serum levels of BDNF, NGF and GDNF in young adults presenting bipolar disorder (BD). This is a randomized clinical trial including 39 young adults (18-29 years) diagnosed with BD through the Structured Clinical Interview for DSM-IV (SCID-CV). Participants were randomized in two treatment groups: usual treatment (medication) and combined intervention (medication plus psychoeducation). Depressive symptoms were assessed using the Hamilton Depression Rating Scale (HDRS) and severity of manic and hypomanic symptoms was evaluated through the Young Mania Rating Scale (YMRS)...
July 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28803030/neurofeedback-sham-neurofeedback-and-cognitive-behavioural-group-therapy-in-adults-with-attention-deficit-hyperactivity-disorder-a-triple-blind-randomised-controlled-trial
#17
Michael Schönenberg, Eva Wiedemann, Alexander Schneidt, Jonathan Scheeff, Alexander Logemann, Philipp M Keune, Martin Hautzinger
BACKGROUND: Many studies suggest that electroencephalographic (EEG) neurofeedback might be beneficial in the treatment of attention-deficit hyperactivity disorder (ADHD). However, numbers of well controlled studies are low and neurofeedback techniques are regarded as highly controversial. The present trial examined the efficacy (compared with sham neurofeedback) and efficiency (compared with meta-cognitive therapy) of a standard EEG neurofeedback protocol in adults with ADHD. METHODS: We did a concurrent, triple-blind, randomised, controlled trial using authorised deception in adults with ADHD from one centre (University of Tübingen) in Tübingen, Germany...
August 9, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28802938/impulse-control-and-related-disorders-in-parkinson-s-disease
#18
Daniel Weintraub, Daniel O Claassen
Impulse control disorders (ICDs), such as compulsive gambling, buying, sexual, and eating behaviors, are a serious and increasingly recognized complication in Parkinson's disease (PD), occurring in up to 20% of PD patients over the course of their illness. Related behaviors include punding (stereotyped, repetitive, purposeless behaviors), dopamine dysregulation syndrome (DDS) (compulsive medication overuse), and hobbyism (e.g., compulsive internet use, artistic endeavors, and writing). These disorders have a significant impact on quality of life and function, strain interpersonal relationships, and worsen caregiver burden, and are associated with significant psychiatric comorbidity...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28802897/the-different-effects-of-lithium-and-tamoxifen-on-memory-formation-and-the-levels-of-neurotrophic-factors-in-the-brain-of-male-and-female-rats
#19
Samira S Valvassori, Cenita Borges, Roger B Varela, Daniela V Bavaresco, Guilherme Bianchini, Edemilson Mariot, Camila O Arent, Wilson R Resende, Josiane Budni, João Quevedo
Lithium (Li) is a mood-stabilizing drug used in the treatment of bipolar disorder (BD). Recently, preclinical studies have demonstrated the potential of tamoxifen (TMX) in the treatment of acute episodes of BD. However, the prolonged use of TMX for mood disorders treatment is controversial. In this study, we evaluated the effects of TMX or Li on cognitive behavior, as well as the levels of neurotrophic factors in the brain of male and female rats. Male and female Wistar rats received administrations of water (control group), TMX or Li via gavage for a period of 28 days; the rats were then subjected to the open-field test (to evaluate spontaneous locomotion), and the novel object recognition and step-down inhibitory avoidance tests (to evaluate cognition)...
August 9, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28802190/alcohol-use-and-bipolar-disorders-risk-factors-associated-with-their-co-occurrence-and-sequence-of-onsets
#20
Jean-Michel Azorin, Léa C Perret, Eric Fakra, Sébastien Tassy, Nicolas Simon, Marc Adida, Raoul Belzeaux
BACKGROUND: Little is known about the sequence of onsets in patients affected by comorbid alcohol use and bipolar disorder. This study examines the risk factors associated with their co-occurrence and order of onset. METHOD: The demographic, clinical, and temperament characteristics as well as the course of illness were analyzed within our sample of 1090 DSM-IV bipolar I manic patients. Our sample was categorized according to the presence of comorbid alcohol use disorder and the sequence of onsets of bipolar and alcohol use disorders i...
August 3, 2017: Drug and Alcohol Dependence
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