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https://www.readbyqxmd.com/read/29785673/the-impact-of-transcranial-direct-current-stimulation-tdcs-on-bipolar-depression-mania-and-euthymia-a-systematic-review-of-preliminary-data
#1
Clément Dondé, Nicholas H Neufeld, Pierre A Geoffroy
The neurobiological basis of bipolar disorders (BD) has received increased attention and several brain regions and brain circuits have been correlated with clinical symptoms. These brain regions and circuits may represent targets for neuromodulation techniques such as transcranial Direct Current Stimulation (tDCS). We systematically reviewed the literature to explore the risks and benefits of tDCS in BD and examined all mood states. Following the PRISMA guidelines, a systematic literature search using several databases was performed from April 2002 to June 2017...
May 21, 2018: Psychiatric Quarterly
https://www.readbyqxmd.com/read/29782956/attentional-engagement-increases-inferior-frontal-gyrus-activity-and-mutes-limbic-activity-in-pediatric-bipolar-disorder-meta-analyses-of-fmri-studies
#2
Moon-Soo Lee, Purnima Anumagalla, Prasanth Talluri, Mani N Pavuluri
OBJECTIVES: Attentional deficit has been shown to exist in adult and pediatric bipolar disorder across the life span. Given that emotional dysregulation is central to bipolar disorder, this study hypothesizes that emotional circuitry regions are altered along with anomalies in the attentional systems during cognitive deployment in bipolar disorder. METHODS: An activation likelihood estimation meta-analysis of attentional activities using GingerALE software was completed for adult and pediatric bipolar disorder populations in all published studies till December 2017...
May 18, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29781886/axis-ii-personality-disorders-are-linked-to-an-adverse-course-of-bipolar-disorder
#3
Robert M Post, Susan McElroy, Ralph Kupka, Trisha Suppes, Gerhard Hellemann, Willem Nolen, Mark Frye, Paul Keck, Heinz Grunze, Michael Rowe
The relationship of personality disorder (PD) psychopathology to the course of bipolar disorder remains inadequately described. After giving informed consent, more than 782 outpatients with bipolar disorder rated themselves on the 99-item Personality Disorder Questionnaire, Version 4 (PDQ4) when depressed or euthymic. They also rated six poor prognosis factors (PPFs). The relationships of the PPFs to the total PDQ4 score were examined by a linear regression. Even after correcting for the higher PDQ4 scores observed when patients were suffering depression, the PDQ4 was significantly related to a history of child abuse, early age of onset, an anxiety disorder comorbidity, rapid cycling, and 20 or more previous episodes, but not substance abuse...
May 17, 2018: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29781657/longitudinal-stability-of-cognitive-control-in-early-psychosis-nondegenerative-deficits-across-diagnoses
#4
Jason Smucny, Tyler A Lesh, Ana-Maria Iosif, Tara A Niendam, Laura M Tully, Cameron S Carter
Cognitive impairment, particularly in the domain of cognitive control, is characteristic of schizophrenia (SZ) spectrum and bipolar disorders (BDs). The longitudinal trajectory of these impairments, however, remains unclear. Indeed, some studies have observed degeneration and others stability or even improvement over time in these illnesses. Here we examined the longitudinal stability of the AX-Continuous Performance Task (AX-CPT), a cognitive control task, in 52 patients with recent-onset SZ (<2 years from first study measurement), 20 patients with recent-onset BD Type I with psychotic features, and 70 healthy control subjects...
May 21, 2018: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29781205/double-trouble-weekend-sleep-changes-are-associated-with-increased-impulsivity-among-adolescents-with-bipolar-i-disorder
#5
Anda Gershon, Sheri L Johnson, Leigh Thomas, Manpreet K Singh
OBJECTIVES: Both sleep disruption and impulsivity are important predictors of the course of bipolar disorder (BD). Although sleep disruption has been shown to intensify impulsivity, little research has considered how these two important domains interact within BD. Adolescence is a critical period for the onset of BD, and is often associated with increases in impulsivity and substantial changes in sleep. We tested the hypothesis that disruptions in sleep would increase impulsivity among adolescents, and that this effect would be more pronounced among those with BD...
May 20, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29780538/competition-between-li-and-na-in-sodium-transporters-and-receptors-which-na-binding-sites-are-therapeutic-li-targets
#6
Todor Dudev, Karine Mazmanian, Carmay Lim
Sodium (Na+ ) acts as an indispensable allosteric regulator of the activities of biologically important neurotransmitter transporters and G-protein coupled receptors (GPCRs), which comprise well-known drug targets for psychiatric disorders and addictive behavior. How selective these allosteric Na+ -binding sites are for the cognate cation over abiogenic Li+ , a first-line drug to treat bipolar disorder, is unclear. Here, we reveal how properties of the host protein and its binding cavity affect the outcome of the competition between Li+ and Na+ for allosteric binding sites in sodium transporters and receptors...
May 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29779901/white-matter-disruptions-in-patients-with-bipolar-disorder
#7
Lucija Abramovic, Marco P M Boks, Annabel Vreeker, Sanne Verkooijen, Annet H van Bergen, Roel A Ophoff, René S Kahn, Neeltje E M van Haren
Bipolar disorder (BD) patients show aberrant white matter microstructure compared to healthy controls but little is known about the relation with clinical characteristics. We therefore investigated the relation of white matter microstructure with the main pharmacological treatments as well its relation with IQ. Patients with BD (N = 257) and controls (N = 167) underwent diffusion tensor imaging (DTI) and comprehensive clinically assessments including IQ estimates. DTI images were analyzed using tract-based spatial statistics...
May 17, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29778935/different-levels-of-pro-and-anti-inflammatory-cytokines-in-patients-with-unipolar-and-bipolar-depression
#8
Ruizhi Mao, Chen Zhang, Jun Chen, Guoqing Zhao, Rubai Zhou, Fan Wang, Jingjing Xu, Tao Yang, Yousong Su, Jia Huang, Zhiguo Wu, Lan Cao, Yong Wang, Yingyan Hu, Chengmei Yuan, Zhenghui Yi, Wu Hong, Zuowei Wang, Daihui Peng, Yiru Fang
BACKGROUND: Immune system dysregulation is critical in the physiopathology of major depressive disorder (MDD) and bipolar disorder (BD). However, it is unclear whether both diseases present the same inflammatory patterns during depressive episodes. We explored the differences in pro- and anti-inflammatory cytokines between unipolar and bipolar depression (BDD) and the trajectory of these cytokines after acute-phase treatment. METHODS: Sixty-four MDD patients, 61 BDD patients, and 62 healthy controls (HCs) were enrolled...
April 25, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29778833/suicide-attempts-and-clinical-correlates-in-patients-with-bipolar-i-vs-ii-disorder
#9
EDITORIAL
Matteo Vismara, Benedetta Grancini, Laura Cremaschi, Lucio Oldani, Chiara Arici, Vera de Carlo, Shefali Miller, Terence A Ketter, A Carlo Altamura, Bernardo Dell'Osso
No abstract text is available yet for this article.
May 17, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29778806/evaluation-of-antioxidant-potential-of-novel-layered-double-hydroxides-with-caal-and-nial-loaded-with-olanzapine
#10
João Gomes Pontes-Neto, Danilo Augusto Ferreira Fontes, Magaly Andreza Marques de Lyra, Maria Dos Remédios Mendes de Brito, Luíse Lopes Chaves, Pedro José Rolim-Neto, Mônica Felts De La Roca Soares, Lucindo Jose Quintans Júnior, Rivelilson Mendes de Freitas, José Lamartine Soares-Sobrinho
Olanzapine (OLZ), Class II in the Biopharmaceutical Classification System, has low aqueous solubility, hindering its absorption after administration. It is used in the bipolar disorder and schizophrenia treatment, diseases that present the oxidative stress in their pathophysiology. In the search for new Drug Delivery Systems (DDS) that enhance the OLZ dissolution rate, it is also necessary to investigate its antioxidant potential for better understanding. Thus, this study aimed to evaluate the in vitro antioxidant potential of new olanzapine DDS based on two different types of Layered Double Hydroxides (LDH systems)...
May 17, 2018: Life Sciences
https://www.readbyqxmd.com/read/29778054/at-risk-symptoms-of-bipolar-disorder-in-a-university-student-cohort
#11
Ida S Haussleiter, Sandra Lorek, Eike Zeschel, Svenja Mattausch, Milena Meyers, Georg Juckel
To assess the occurrence and frequency of bipolar at-risk symptoms in a large sample of previously undiagnosed students using the new screening tool Bochumer Screeningbogen Bipolar (BSB). 2329 students of the Ruhr-University Bochum, Germany completed online demographic data as well as various self-rating questionnaires (BSB; Hypomania Checklist 32; Altman Self-Rating Mania Scale; Beck Depression Inventory). Within the student cohort (64.4% female, mean age 24.3 years) every fifth student currently suffered from moderate to severe depressive symptoms; every sixth student had already thought about suicide and every other student reported a history of mood swings...
May 6, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29777563/cognitive-and-functional-deficits-in-bipolar-disorder-and-schizophrenia-as-a-function-of-the-presence-and-history-of-psychosis
#12
Christopher R Bowie, Michael W Best, Colin Depp, Brent T Mausbach, Thomas L Patterson, Ann E Pulver, Philip D Harvey
OBJECTIVES: Schizophrenia and bipolar disorder overlap considerably. Schizophrenia is a primary psychotic disorder, whereas approximately half of people with bipolar disorder will experience psychosis. In this study, we examined the extent to which cognitive and functional impairments are related to the presence and history of psychosis across the two disorders. METHOD: A total of 633 participants with bipolar disorder I, schizophrenia, and schizoaffective disorder were recruited for a study on the genetics of cognition and functioning in bipolar disorder and schizophrenia...
May 18, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29776917/treatment-refractory-mania-with-psychosis-in-a-post-transplant-patient-on-tacrolimus-a-case-report
#13
Muaid Ithman, Kunal Malhotra, Meelie Bordoloi, Garima Singh
Bipolar affective disorder type I imparts significant morbidity and disease burden in the Population. It is characterized by occurrence of one or more manic episodes which may be preceded or followed by a depressive or hypomanic phase. About half of these manic episodes are characterized by the presence of psychotic features [1]. The condition is further complicated when patient has multiple comorbid conditions. We report here a case of a 66 year old Caucasian female, previously diagnosed with Bipolar disorder who developed treatment refractory mania with psychotic feature after being on Tacrolimus (an immunosuppressive agent) after kidney transplantation...
May 18, 2018: Clinical Medicine & Research
https://www.readbyqxmd.com/read/29776774/association-of-disrupted-circadian-rhythmicity-with-mood-disorders-subjective-wellbeing-and-cognitive-function-a-cross-sectional-study-of-91-105-participants-from-the-uk-biobank
#14
Laura M Lyall, Cathy A Wyse, Nicholas Graham, Amy Ferguson, Donald M Lyall, Breda Cullen, Carlos A Celis Morales, Stephany M Biello, Daniel Mackay, Joey Ward, Rona J Strawbridge, Jason M R Gill, Mark E S Bailey, Jill P Pell, Daniel J Smith
BACKGROUND: Disruption of sleep and circadian rhythmicity is a core feature of mood disorders and might be associated with increased susceptibility to such disorders. Previous studies in this area have used subjective reports of activity and sleep patterns, but the availability of accelerometer-based data from UK Biobank participants permits the derivation and analysis of new, objectively ascertained circadian rhythmicity parameters. We examined associations between objectively assessed circadian rhythmicity and mental health and wellbeing phenotypes, including lifetime history of mood disorder...
May 15, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29776731/comorbidity-in-illness-induced-posttraumatic-stress-disorder-versus-posttraumatic-stress-disorder-due-to-external-events-in-a-nationally-representative-study
#15
Jordana L Sommer, Natalie Mota, Donald Edmondson, Renée El-Gabalawy
OBJECTIVE: The current study compared physical and mental health characteristics and quality of life of illness-induced posttraumatic stress disorder (PTSD) versus those with PTSD due to external traumatic events in a population-based sample. METHOD: PTSD was assessed with the Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS-5) using DSM-5 criteria in the 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions. Participants with past-year PTSD (n = 1779) were categorized into two groups: illness-induced (6...
May 10, 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29775085/usage-of-therapeutic-sleep-deprivation-a-survey-in-psychiatric-hospitals-in-austria-germany-and-switzerland
#16
Dietmar Winkler, Marie Spies, Yasmin Al-Resheg, Joseph C Wu, William E Bunney, Blynn G Bunney, Siegfried Kasper, Edda Pjrek
OBJECTIVE: Therapeutic sleep deprivation (SD) is a nonpharmacological treatment that is used most often for depression. The aim of this study was to examine the pattern of use of SD in psychiatric hospitals in Austria, Germany, and Switzerland. METHODS: A questionnaire about perceived usage of SD was sent by mail to all 511 psychiatric hospitals in the three countries. Nonresponders were asked to answer the questionnaire by phone. We achieved a response rate of 75...
May 18, 2018: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/29771866/bipolar-disorder-is-associated-with-an-increased-risk-of-sexually-transmitted-infections-a-nationwide-population-based-cohort-study
#17
Shih-Fen Chen, Ling-Yi Wang, Jen-Huai Chiang, Yu-Chih Shen
BACKGROUND: Previous studies have suggested that sexually transmitted infections (STI) tend to increase in patients with bipolar disorder during a manic or hypomanic episode. However, in the long-term course of this disease, it is unclear whether patients with bipolar disorder have a higher risk of incident STI. METHODS: Using the National Health Insurance Research Database (NHIRD) of Taiwan, 3,721 patients with bipolar disorder and 14,884 controls without bipolar disorder matched by gender and age were enrolled between 2000 and 2010 and followed until the end of 2013...
May 1, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29769459/the-framework-of-clinical-occupational-medicine-to-provide-new-insight-for-workaholism
#18
Quentin Durand-Moreau, Clarisse LE Deun, Brice Lodde, Jean-Dominique Dewitte
There is no single agreed definition of workaholism. Most interventions proposed for people suffering from workaholism target individuals. There is a paucity of descriptions of workplace risk factors. Our study examines case reports of patients suffering from workaholism with a focus on the role of the workplace. We describe case reports from patients of the Occupational Disease Centre in Brest, France between 2013 and 2016. Consultations were conducted within the framework of clinical occupational medicine with a focus on real work situations...
May 17, 2018: Industrial Health
https://www.readbyqxmd.com/read/29768917/how-native-and-non-native-cations-bind-and-modulate-the-properties-of-gtp-atp
#19
Todor Dudev, Cedric Grauffel, Shang-Te Danny Hsu, Carmay Lim
Adenosine triphosphate (ATP) and guanosine triphosphate (GTP) exist in physiological solution mostly bound to cations. Interestingly, their cellular Mg2+ -bound forms have been shown to bind Li+ , a first-line drug for bipolar disorder. However, solution structures of NTP/NDP (N = A or G) bound to Li+ and/or Mg2+ have not been solved, thus precluding knowledge of how the native Mg2+ -bound cofactor conformation changes upon binding non-native Li+ and/or switching its environment from aqueous solution to proteins...
May 16, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29768498/genomic-variants-in-an-inbred-mouse-model-predict-mania-like-behaviors
#20
Michael C Saul, Sharon A Stevenson, Changjiu Zhao, Terri M Driessen, Brian E Eisinger, Stephen C Gammie
Contemporary rodent models for bipolar disorders split the bipolar spectrum into complimentary behavioral endophenotypes representing mania and depression. Widely accepted mania models typically utilize single gene transgenics or pharmacological manipulations, but inbred rodent strains show great potential as mania models. Their acceptance is often limited by the lack of genotypic data needed to establish construct validity. In this study, we used a unique strategy to inexpensively explore and confirm population allele differences in naturally occurring candidate variants in a manic rodent strain, the Madison (MSN) mouse strain...
2018: PloS One
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