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Upper gastrointestinal bleeding

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https://www.readbyqxmd.com/read/29774150/the-effect-of-off-hours-hospital-admission-on-mortality-and-clinical-outcomes-for-patients-with-upper-gastrointestinal-hemorrhage-a-systematic-review-and-meta-analysis-of-20-cohorts
#1
Xian Feng Xia, Philip Wai Yan Chiu, Kelvin Kam Fai Tsoi, Francis Ka Leung Chan, Joseph Jao Yiu Sung, James Yun Wong Lau
Objective: The objective of this article is to evaluate the relationship between off-hours hospital admission (weekends, public holidays or nighttime) and mortality for upper gastrointestinal hemorrhage (UGIH). Methods: Medline, Embase, Scopus, and the Chinese Biomedical Literature were searched through December 2016 to identify eligible records for inclusion in this meta-analysis. A random-effects model was applied. Results: Twenty cohort studies were included for analysis...
April 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29754836/misoprostol-for-small-bowel-ulcers-in-patients-with-obscure-bleeding-taking-aspirin-and-non-steroidal-anti-inflammatory-drugs-masters-a-randomised-double-blind-placebo-controlled-phase-3-trial
#2
Ali S Taha, Caroline McCloskey, Paula McSkimming, Alex McConnachie
BACKGROUND: The incidence of obscure gastrointestinal bleeding, which originates from the small bowel and is mainly associated with the use of aspirin and non-steroidal anti-inflammatory drugs (NSAIDs), is rising. We assessed the efficacy and safety of misoprostol for the treatment of small bowel ulcers and erosions in patients taking low-dose aspirin or NSAIDs with obscure gastrointestinal bleeding. METHODS: In this randomised, double-blind, placebo-controlled, phase 3 trial, we recruited patients (aged ≥18 years) with small bowel ulcers who were taking low-dose aspirin, NSAIDs, or both for a minimum of 4 weeks, at University Hospital Crosshouse (Kilmarnock, UK)...
May 10, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29749322/bacteremia-in-cirrhotic-patients-with-upper-gastrointestinal-bleeding
#3
Hsin-An Shih, Pei-Chuan Tsai, Kai-Hsiang Wu, Yi-Ting Chen, Yi-Chuan Chen
BACKGROUND/AIMS: Increased risk of bacterial infection is common in cirrhotic patients with upper gastrointestinal bleeding (UGIB). Our study aimed to explore the association of the bacteremia with in-hospital mortality and risk factors of bacteremia in these patients. MATERIALS AND METHODS: In our retrospective cohort study, we collected data for cirrhotic patients with UGIB admitted to our hospital between August 2010 and December 2010. The primary outcome was in-hospital mortality...
March 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29748820/trans-arterial-embolization-of-non-variceal-upper-gastrointestinal-bleeding-is-the-use-of-ethylene-vinyl-alcohol-copolymer-as-safe-as-coils
#4
Marcello Andrea Tipaldi, Gianluigi Orgera, Miltiadis Krokidis, Alberto Rebonato, Daniele Maiettini, Simone Vagnarelli, Cesare Ambrogi, Michele Rossi
PURPOSE: The safety of liquid embolics over the conventional coils for the treatment of non-variceal upper gastrointestinal bleeding (UGIB) approach is still unclear. Purpose of this study is to assess the safety of ethylene-vinyl alcohol copolymer (EVOH 6%) over coils in the treatment of UGIB. MATERIALS AND METHODS: All the upper gastrointestinal tract embolization procedures performed in a single center in a 6-year period were reviewed. Patients embolised with coils (Group A) versus those embolised with EVOH 6% (Group B) were compared...
May 10, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29744052/hemosuccus-pancreaticus-a-mini-review
#5
REVIEW
Peng Yu, Jianping Gong
Determining the cause of obscure bleeding in the gastrointestinal tract is the key in treating the disease. Hemosuccus pancreaticus (HP) could be an extremely rare disease. Ordinarily, bleeding in the pancreatic duct is defined as HP. At present, HP is the least frequent cause of upper gastrointestinal bleeding (1/1500), but can lead to massive gastrointestinal bleeding, which is potentially life threatening. Owing to its rarity, HP is difficult to diagnose, and the mortality rate of HP remains high in various studies...
April 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29743802/upper-gastrointestinal-bleed-due-to-invasive-hepatocellular-carcinoma-and-hepato-gastric-fistula
#6
Abhijith Bale, Shiran Shetty, Anurag Shetty, Girisha Balaraju, Cannanore Ganesh Pai
No abstract text is available yet for this article.
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29742774/massive-upper-gastrointestinal-bleeding-post-whipple-s-surgery-from-anastomotic-varices-due-to-mesenteric-hypertension
#7
Yu Jun Wong, Farah Gillian Irani, Malcolm Tan, Melissa Teo
No abstract text is available yet for this article.
May 9, 2018: Endoscopy
https://www.readbyqxmd.com/read/29732154/unusual-growth-of-an-epstein-barr-virus-associated-differentiated-early-stage-gastric-carcinoma-a-case-report
#8
Noriyuki Horiguchi, Tomomitsu Tahara, Tomohiko Kawamura, Masaaki Okubo, Takamitsu Ishizuka, Naoko Nakano, Yoshihito Nakagawa, Mitsuo Nagasaka, Mitsuru Nakagawa, Tetsuya Tsukamoto, Tomoyuki Shibata, Naoki Ohmiya
Epstein-Barr virus (EBV) infection is involved in a subset of gastric carcinoma (GC) cases, and is associated with distinct clinicopathological features. The present study reports a unique case of EBV-associated early-stage GC compared with the other cases experienced in our hospital. A 72-year-old male receiving treatment for cerebral infarction underwent an esophagogastroduodenoscopy (EGD) for suspicion of gastrointestinal bleeding. EGD revealed a type 0-I protruding lesion in the lesser curvature of the upper gastric corpus...
May 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29725977/gastrosplenic-fistula-with-gastrointestinal-bleeding-a-rare-and-potentially-fatal-complication-after-sleeve-gastrectomy
#9
Laura Montana, Laurent Genser, Alexandre Cortes, Eric Poupardin, Christophe Barrat, Sergio Carandina
BACKGROUND: Although the surgical technique is safe and standardized, laparoscopic sleeve gastrectomy (LSG) is associated with serious and potentially life-threatening complications, such as gastric leak and bleeding. METHODS: In this retrospective study, three French university hospitals reviewed their experience with LSG. Between September 2014 and May 2016, three cases of gastrosplenic fistula complicated by massive upper gastrointestinal hemorrhage (UGIH) were recorded...
May 3, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29725533/ulcerated-gastric-leiomyoma-causing-massive-upper-gastrointestinal-bleeding-a-case-report
#10
Daryl Ramai, Qiuxue T Tan, Sofia Nigar, Emmanuel Ofori, Denzil Etienne, Madhavi Reddy
Leiomyomas are rare, benign submucosal tumors originating from smooth muscle cells. The clinical presentation is usually asymptomatic, with excellent prognosis. We herein report the case of a 68-year-old female with a solitary leiomyoma found during esophagogastroduodenoscopy for hematemesis. Histopathological examination revealed smooth muscle proliferation supported by positive staining for smooth muscle myosin heavy chain and negative staining for CD117 and S-100, consistent with the marker expression pattern of leiomyoma...
May 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29724628/the-rare-coexistence-of-high-titer-inhibitor-development-and-gastrointestinal-stromal-tumor-in-a-patient-with-severe-hemophilia-a-case-report
#11
Abdulkerim Yıldız, Osman Şahin, Okan Yayar, Çiğdem Pala Öztürk, Hacer Berna Afacan Öztürk, Senem Maral, Harika Okutan, Murat Albayrak
Hemophilia is a hereditary disease with impaired blood coagulation due to a genetic deficiency of blood coagulation factors. The development of inhibitors further complicates the course of the disease and management. The case is here reported of a haemophilia patient who presented with coexisting development of high titer inhibitor with Gastrointestinal Stromal Tumor (GIST) diagnosis and was admitted with upper gastrointestinal system bleeding. The patient had no prior history of inhibitor presence. During all procedures including surgery, excellent hemostasis was achieved with rFVIIa treatment and no hemorrhagic complication was observed...
April 26, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29721346/hsct-gave-as-a-manifestation-of-chronic-graft-versus-host-disease-a-case-report-and-review-of-the-existing-literature
#12
Michael J Grant, Mitchell E Horwitz
Gastric antral vascular ectasia or "watermelon stomach" is a significant cause of nonvariceal upper GI bleeding and is characterized by red, tortuous ectatic vessels along longitudinal folds in the gastric antrum. The existing literature links GAVE to patients with cirrhosis, scleroderma, bone marrow transplantation, and chronic renal failure among other associations, but its pathophysiology remains ill-defined. Over 30 cases of hematopoietic stem cell transplant-related GAVE (HSCT-GAVE) have been reported in the literature to date and there are likely many more that go undiagnosed or are attributed to another cause of upper gastrointestinal bleeding...
2018: Case Reports in Transplantation
https://www.readbyqxmd.com/read/29721011/a-new-scoring-system-to-predict-poor-clinical-outcomes-in-acute-nonvariceal-upper-gastrointestinal-bleeding-patients-with-high-risk-stigmata
#13
Zhiyu Dong, Junwen Wang, Tingting Zhan, Haiqin Zhang, Lisha Yi, Shuchang Xu
Aims: To explore the risk factors for rebleeding in acute nonvariceal upper gastrointestinal bleeding patients with high-risk stigmata after endoscopic hemostasis and to develop a new scoring system for them. Methods: A retrospective single-center study was conducted from January 2012 to June 2017. The logistic regression model was used to explore risk factors of poor clinical outcomes. Accuracy of new scoring systems was compared with Rockall score (RS) and Glasgow-Blatchford score (GBS) using receiver operating characteristics curve...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29720867/synchronous-gastric-and-duodenal-metastases-from-head-and-neck-squamous-cell-carcinoma-a-unique-presentation-of-upper-gastrointestinal-bleeding
#14
Nicholas P Tarangelo, C Andrew Kistler, Zachary Daitch, Wei Jiang, Daniel M Quirk
Metastatic disease to the stomach or duodenum is an infrequent diagnosis, and head and neck squamous cell carcinoma (HNSCC) is one of the least common primary malignancies that lead to gastric or duodenal metastases. We report the case of a 65-year-old man with human immunodeficiency virus infection and previously diagnosed HNSCC who presented with melena. The patient had a percutaneous endoscopic gastrostomy tube placed 3 months prior to his presentation. Laboratory testing was significant for normocytic anemia and a digital rectal examination was positive for melena...
May 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29720248/outcome-pre-specification-requires-sufficient-detail-to-guard-against-outcome-switching-in-clinical-trials-a-case-study
#15
Brennan C Kahan, Vipul Jairath
BACKGROUND: Pre-specification of outcomes is an important tool to guard against outcome switching in clinical trials. However, if the outcome is not sufficiently clearly defined, then different definitions could be applied and analysed, with only the most favourable result reported. METHODS: In order to assess the impact that differing outcome definitions could have on treatment effect estimates, we re-analysed data from TRIGGER, a cluster randomised trial comparing two red blood cell transfusion strategies for patients with acute upper gastrointestinal bleeding...
May 2, 2018: Trials
https://www.readbyqxmd.com/read/29719748/does-early-endoscopy-improve-mortality-in-patients-with-acute-non-variceal-gastrointestinal-bleeding-a-retrospective-review
#16
Umair Iqbal, Hafsa Anwar, Hunaiz Patel, Ahmad Chaudhary, Pascale Raymond
Introduction Initial management of acute upper gastrointestinal bleeding (UGIB) aims towards aggressive fluid resuscitation to maintain hemodynamic stability. Existing evidence regarding the benefit of early endoscopy is unclear with some studies suggesting mortality benefits and some suggesting otherwise. The purpose of this study is to evaluate if there is any mortality benefit of doing early endoscopy within 24 hours of presentation. Methods From July 2013 to July 2016, 179 patients admitted with a diagnosis of non-variceal UGIB were retrospectively reviewed...
February 28, 2018: Curēus
https://www.readbyqxmd.com/read/29718891/risk-factors-associated-with-nonsteroidal-anti-inflammatory-drugs-nsaids-induced-gastrointestinal-bleeding-resulting-on-people-over-60-years-old-in-beijing
#17
Tian-Yu Chi, Hong-Ming Zhu, Mei Zhang
Gastrointestinal (GI) bleeding is an unwanted side effect common to all chemical types of nonsteroidal anti-inflammatory drugs (NSAIDs), particularly in elderly people. However, the risk factors of GI bleeding associated with NSAIDs for elderly people remain unknown. This study aims to evaluate the risks of GI bleeding associated with NSAIDs in 4728 elderly people over 60 years old based on database from a hospital in Beijing.This retrospective hospital-based study included 4728 patients over 60 years old prescribed with NSAIDs, of which 928 patients had GI bleeding and 3800 did not have...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29713638/omeprazole-minimally-alters-the-fecal-microbial-community-in-six-cats-a-pilot-study
#18
Sarah M Schmid, Jan S Suchodolski, Josh M Price, M K Tolbert
Although they have historically been thought of as safe medications, proton pump inhibitors such as omeprazole have been associated with an increased risk of enteric, particularly Clostridium difficile , infections in people. In cats, omeprazole is often the first choice acid suppressant prescribed for the treatment of upper gastrointestinal (GI) ulceration and bleeding. Despite this, no studies to date have explored the effect of omeprazole on the feline fecal microbiome and metabolome. Therefore, the purpose of this pilot study was to evaluate the effect of prolonged omeprazole administration on the fecal microbiome and metabolome in healthy cats to identify targets for analysis in a larger subset of cats with GI disease...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29713571/superior-vena-cava-obstruction-a-rare-cause-of-recurrent-esophageal-variceal-bleeding
#19
Agazi Gebreselassie, Ahmad Awan, Hamid Yaqoob, Adeyinka Laiyemo
"Downhill" esophageal varices are formed in upper two-thirds of the esophagus as a consequence of a superior vena cava obstruction. We present a case of 55-year-old African-American female with a medical history of multiple comorbidities, including end-stage renal disease, who presented with an upper gastrointestinal bleed and was found to have distended neck veins on physical examination. She gave a history of the insertion of an intravenous central line in her neck area for hemodialysis purposes about six years previously...
February 26, 2018: Curēus
https://www.readbyqxmd.com/read/29705263/previous-use-of-anti-thrombotic-agents-reduces-mortality-and-length-of-hospital-stay-in-patients-with-high-risk-upper-gastrointestinal-bleeding
#20
Philip Dj Dunne, Stig B Laursen, Loren Laine, Harry R Dalton, Jing H Ngu, M Schultz, Adam Rahman, Andrea Anderloni, Iain A Murray, Adrian J Stanley
BACKGROUND AND AIMS: Anti-thrombotic agents are risk factors for upper gastrointestinal bleeding (UGIB). However, few studies have evaluated their effects on patient outcomes. We assessed the effects of anti-thrombotic agents on outcomes of patients with high-risk UGIB. METHODS: We performed a prospective study of 619 patients with acute UGIB (defined by hematemesis, coffee-ground vomit or melena) who required intervention and underwent endoscopy at 8 centers in North America, Asia, and Europe, from March 2014 through March 2015...
April 26, 2018: Clinical Gastroenterology and Hepatology
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