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https://www.readbyqxmd.com/read/27888865/advances-in-gastrointestinal-bleeding
#1
Ángel Lanas
The main innovations of the latest meeting of the Gastroenterological Association (2016) concerning upper gastrointestinal bleeding from the clinician's perspective can be summarised as follows: a) The Glasgow-Blatchford scale has the best accuracy in predicting the need for surgical intervention and hospital mortality; b) Prognostic scales for non-variceal upper gastrointestinal bleeding are also useful for lower gastrointestinal bleeding; c) Preliminary data suggest that treatment with hemospray does not seem to be superior to current standard treatment in controlling active peptic ulcer bleeding; d) Either famotidine or a proton pump inhibitor may be effective in preventing haemorrhagic recurrence in patients taking aspirin, but this finding needs to be confirmed in further studies; e) There was confirmation of the need to re-introduce antiplatelet therapy as early as possible in patients with antiplatelet-associated gastrointestinal bleeding in order to prevent cardiovascular mortality; f) Routine clinical practice suggests that gastrointestinal or cardiovascular complications with celecoxib or traditional NSAIDs are very low; g) Dabigatran is associated with an increased incidence of gastrointestinal bleeding compared with apixaban or warfarin...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27861708/high-dose-monthly-vitamin-d-for-prevention-of-acute-respiratory-infection-in-older-long-term-care-residents-a-randomized-clinical-trial
#2
Adit A Ginde, Patrick Blatchford, Keith Breese, Lida Zarrabi, Sunny A Linnebur, Jeffrey I Wallace, Robert S Schwartz
OBJECTIVES: To determine the efficacy and safety of high-dose vitamin D supplementation for prevention of acute respiratory infection (ARI) in older long-term care residents. DESIGN: Randomized controlled trial investigating high-dose vs standard-dose vitamin D from 2010 to 2014. SETTING: Colorado long-term care facilities. PARTICIPANTS: Long-term care residents aged 60 and older (n = 107). INTERVENTION: The high-dose group received monthly supplement of vitamin D3 100,000 IU, the standard-dose group received a monthly placebo (for participants taking 400-1,000 IU/d as part of usual care) or a monthly supplement of 12,000 IU of vitamin D3 (for participants taking <400 IU/d as part of usual care)...
November 16, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27826205/comparison-of-glasgow-blatchford-score-and-full-rockall-score-systems-to-predict-clinical-outcomes-in-patients-with-upper-gastrointestinal-bleeding
#3
Marjan Mokhtare, Vida Bozorgi, Shahram Agah, Mehdi Nikkhah, Amirhossein Faghihi, Amirhossein Boghratian, Neda Shalbaf, Abbas Khanlari, Hamidreza Seifmanesh
BACKGROUND: Various risk scoring systems have been recently developed to predict clinical outcomes in patients with upper gastrointestinal bleeding (UGIB). The two commonly used scoring systems include full Rockall score (RS) and the Glasgow-Blatchford score (GBS). Bleeding scores were assessed in terms of prediction of clinical outcomes in patients with UGIB. PATIENTS AND METHODS: Two hundred patients (age >18 years) with obvious symptoms of UGIB in the emergency department of Rasoul Akram Hospital were enrolled...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27740523/validation-of-prognostic-scores-for-clinical-outcomes-in-cirrhotic-patients-with-acute-variceal-bleeding
#4
Miguel Motola-Kuba, Angélica Escobedo-Arzate, Félix Tellez-Avila, José Altamirano, Nancy Aguilar-Olivos, Alberto González-Angulo, Felipe Zamarripa-Dorsey, Misael Uribe, Norberto C Chávez-Tapia
: Background. The Rockall, Glasgow-Blatchford, and AIMS65 are useful and validated scoring systems for predicting the outcomes of patients with nonvariceal gastrointestinal bleeding. However, there are no validated evidence for using them to predict outcomes on variceal bleeding. The aim of this study was to evaluate and compare the prognostic accuracy of different nonvariceal bleeding scores with other liver-specific scoring systems in cirrhotic patients. MATERIAL AND METHODS: A retrospective multicenter study that included 160 cirrhotic patients with acute variceal bleeding...
November 2016: Annals of Hepatology
https://www.readbyqxmd.com/read/27693643/timing-of-upper-endoscopy-influences-outcomes-in-patients-with-acute-nonvariceal-upper-gi-bleeding
#5
Navin L Kumar, Aaron J Cohen, Jennifer Nayor, Brian L Claggett, John R Saltzman
BACKGROUND: Current guidelines advise that upper endoscopy be performed within 24 hours of presentation in patients with acute nonvariceal upper gastrointestinal bleeding (UGIB). However, the role of urgent endoscopy (< 12 hours) is controversial. AIM: Our aim was to assess whether patients admitted with acute nonvariceal UGIB with lower-risk versus high-risk bleeding have different outcomes with urgent compared with non-urgent endoscopy. METHODS: A retrospective cohort study was conducted of patients admitted to an academic hospital with nonvariceal UGIB...
September 29, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27652296/the-efficacy-of-hemospray-in-patients-with-upper-gastrointestinal-bleeding-from-tumor
#6
Rapat Pittayanon, Piyapan Prueksapanich, Rungsun Rerknimitr
BACKGROUND AND STUDY AIMS: Currently, conventional endoscopic treatments provide an unsatisfactory hemostatic outcome in upper gastrointestinal bleeding from tumor. Hemospray has been shown to be useful in many active gastrointestinal bleeding conditions. This study aimed to compare the efficacy of Hemospray and conventional endoscopic hemostasis. PATIENTS AND METHODS: Fourteen patients with active upper gastrointestinal bleeding from tumor were recruited. Hemospray was applied at the bleeding site until hemostasis was achieved...
September 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27648468/blatchford-score-is-superior-to-aims65-score-in-predicting-the-need-for-clinical-interventions-in-elderly-patients-with-nonvariceal-upper-gastrointestinal-bleed
#7
Khalid Abusaada, Fnu Asad-Ur-Rahman, Vladimir Pech, Umair Majeed, Shengchuan Dai, Xiang Zhu, Sally A Litherland
Background. Blatchford and AIMS65 scores were developed to risk stratify patients with upper gastrointestinal bleed (UGIB). We sought to assess the performance of Blatchford and AIMS65 scores in predicting outcomes in elderly patients with nonvariceal UGIB. Methods. A retrospective cohort study of elderly patients (over 65 years of age) with nonvariceal UGIB admitted to a tertiary care center. Primary outcome was a combined outcome of in-hospital mortality, need for any therapeutic endoscopic, radiologic, or surgical intervention, rebleeding within 30 days, or blood transfusion...
2016: Advances in Medicine
https://www.readbyqxmd.com/read/27640399/the-predictive-value-of-preendoscopic-risk-scores-to-predict-adverse-outcomes-in-emergency-department-patients-with-upper-gastrointestinal-bleeding-a-systematic-review
#8
Rosa Ramaekers, Muhammad Mukarram, Christine A M Smith, Venkatesh Thiruganasambandamoorthy
OBJECTIVES: Risk stratification of emergency department (ED) patients with upper gastrointestinal bleeding (UGIB) using preendoscopic risk scores can aid ED physicians in disposition decision-making. We conducted a systematic review to assess the predictive value of preendoscopic risk scores for 30-day serious adverse events. METHODS: We searched MEDLINE, PubMed, Embase, and the Cochrane Database of Systematic Reviews from inception to March 2015. We included studies involving adult ED UGIB patients evaluating preendoscopic risk scores and excluded reviews, case reports, and animal studies...
November 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/27624697/effective-endoscopic-treatment-of-mallory-weiss-syndrome-using-glasgow-blatchford-score-and-forrest-classification
#9
Sunpyo Lee, Ji Yong Ahn, Hwoon-Yong Jung, Kee Wook Jung, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Jin-Ho Kim, Seon-Ok Kim
AIM: There is limited data on whether scoring systems can be used to predict clinical outcomes in patients with upper gastrointestinal bleeding due to Mallory-Weiss syndrome (MWS). We evaluated whether the Glasgow-Blatchford score (GBS) could be effective in predicting clinical outcomes of bleeding MWS. We also investigated the predictive ability of the Forrest classification for rebleeding and assessed the effective endoscopic modalities for bleeding control in MWS. METHODS: From January 2004 to December 2012, 168 patients were diagnosed with MWS in Asan Medical Center emergency department...
September 13, 2016: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27565018/design-and-rationale-of-the-re-dual-pci-trial-a-prospective-randomized-phase-3b-study-comparing-the-safety-and-efficacy-of-dual-antithrombotic-therapy-with-dabigatran-etexilate-versus-warfarin-triple-therapy-in-patients-with-nonvalvular-atrial-fibrillation
#10
Christopher P Cannon, Savion Gropper, Deepak L Bhatt, Stephen G Ellis, Takeshi Kimura, Gregory Y H Lip, Ph Gabriel Steg, Jurriën M Ten Berg, Jenny Manassie, Jörg Kreuzer, Jon Blatchford, Joseph M Massaro, Martina Brueckmann, Ernesto Ferreiros Ripoll, Jonas Oldgren, Stefan H Hohnloser
Antithrombotic management of patients with atrial fibrillation (AF) undergoing coronary stenting is complicated by the need for anticoagulant therapy for stroke prevention and dual antiplatelet therapy for prevention of stent thrombosis and coronary events. Triple antithrombotic therapy, typically comprising warfarin, aspirin, and clopidogrel, is associated with a high risk of bleeding. A modest-sized trial of oral anticoagulation with warfarin and clopidogrel without aspirin showed improvements in both bleeding and thrombotic events compared with triple therapy, but large trials are lacking...
October 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/27550758/symbolism-and-discovery-eclipses-in-art
#11
REVIEW
Ian Blatchford
There is a fascinating tradition of depicting solar eclipses in Western art, although these representations have changed over time. Eclipses have often been an important feature of Christian iconography, but valued as much for their biblical significance as for the splendour of the physical event. However, as Western culture passed through the Renaissance and Enlightenment the depictions of eclipses came to reflect new astronomical knowledge and a thirst for rational learning well beyond the confines of the church and other elites...
September 28, 2016: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/27507771/a-simple-scoring-system-to-assess-the-need-for-an-endoscopic-intervention-in-suspected-upper-gastrointestinal-bleeding-a-prospective-cohort-study
#12
Masayasu Horibe, Tetsuji Kaneko, Naoto Yokogawa, Takuya Yokota, Osamu Okawa, Yukihiro Nakatani, Yuki Ogura, Juntaro Matsuzaki, Eisuke Iwasaki, Naoki Hosoe, Tatsuhiro Masaoka, John M Inadomi, Hidekazu Suzuki, Takanori Kanai, Shin Namiki
BACKGROUND: Assessment of the emergent endoscopy for upper gastrointestinal bleeding (UGIB) patients has important clinical implications. There is no validated criterion to triage. AIMS: To develop a simple score predicting an endoscopic intervention. METHODS: A prospective cohort study was conducted at a tertiary care centre. Primary outcome was the high-risk stigmata which were well-established endoscopic findings to determine the need for an endoscopic intervention...
October 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27453602/epidemiology-of-infectious-disease-related-death-after-release-from-prison-washington-state-united-states-and-queensland-australia-a-cohort-study
#13
Ingrid A Binswanger, Patrick J Blatchford, Simon J Forsyth, Marc F Stern, Stuart A Kinner
OBJECTIVES: People in prison may be at high risk for infectious diseases and have an elevated risk of death immediately after release compared with later; their risk of death is elevated for at least a decade after release. We compared rates, characteristics, and prison-related risk factors for infectious disease-related mortality among people released from prisons in Queensland, Australia, and Washington State, United States, regions with analogous available data. METHODS: We analyzed data from retrospective cohort studies of people released from prison in Queensland (1997-2007, n=37,180) and Washington State (1999-2009, n=76,208) and linked identifiers from each cohort to its respective national death index...
July 2016: Public Health Reports
https://www.readbyqxmd.com/read/27409091/-comparison-between-glascow-blatchford-rockall-and-aims65-scores-in-patients-with-upper-gastrointestinal-bleeding-in-a-hospital-in-lima-peru
#14
Jorge Espinoza-Ríos, Victor Aguilar Sánchez, Eduar Alban Bravo Paredes, José Pinto Valdivia, Jorge Huerta-Mercado Tenorio
OBJECTIVE: Identify the best score that predicts each variable outcome (mortality, rebleeding and need for transfusion for more than 2 red blood cells pack) in patients with upper gastrointestinal bleeding until 30 days of the event. Material y methods: Patients included were those over 18 years, who had upper gastrointestinal bleeding between January 2014 to June 2015 in a general hospital of third level. The data was analyzed by the area under the curve ROC (Receiver Operating Characteristic)...
April 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/27403303/comparison-of-aims65-glasgow-blatchford-score-and-rockall-score-in-a-european-series-of-patients-with-upper-gastrointestinal-bleeding-performance-when-predicting-in-hospital-and-delayed-mortality
#15
Juan G Martínez-Cara, Rita Jiménez-Rosales, Margarita Úbeda-Muñoz, Mercedes López de Hierro, Javier de Teresa, Eduardo Redondo-Cerezo
OBJECTIVE: AIMS65 is a score designed to predict in-hospital mortality, length of stay, and costs of gastrointestinal bleeding. Our aims were to revalidate AIMS65 as predictor of inpatient mortality and to compare AIMS65's performance with that of Glasgow-Blatchford (GBS) and Rockall scores (RS) with regard to mortality, and the secondary outcomes of a composite endpoint of severity, transfusion requirements, rebleeding, delayed (6-month) mortality, and length of stay. METHODS: The study included 309 patients...
June 2016: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/27377742/comparison-of-aims65-score-and-other-scoring-systems-for-predicting-clinical-outcomes-in-koreans-with-nonvariceal-upper-gastrointestinal-bleeding
#16
Sung Min Park, Seok Cheon Yeum, Byung-Wook Kim, Joon Sung Kim, Ji Hee Kim, Eun Hui Sim, Jeong-Seon Ji, Hwang Choi
BACKGROUND/AIMS: The AIMS65 score has not been sufficiently validated in Korea. The objective of this study was to compare the AIMS65 and other scoring systems for the prediction of various clinical outcomes in Korean patients with acute nonvariceal upper gastrointestinal bleeding (NVUGIB). METHODS: The AIMS65 score, clinical and full Rockall scores (cRS and fRS) and Glasgow-Blatchford (GBS) score were calculated in patients with NVUGIB in a single center retrospectively...
July 15, 2016: Gut and Liver
https://www.readbyqxmd.com/read/27356670/glasgow-blatchford-pre-endoscopic-rockall-and-aims65-scores-show-no-difference-in-predicting-rebleeding-rate-and-mortality-in-variceal-bleeding
#17
Ivan Budimir, Marina Gradišer, Marko Nikolić, Neven Baršić, Neven Ljubičić, Dominik Kralj, Ivan Budimir
OBJECTIVE: To compare the performance of the Glasgow Blatchford score (GBS), pre-endoscopic Rockall score (PRS) and AIMS65 score in predicting specific clinical endpoints following variceal upper gastrointestinal hemorrhage (UGIH). MATERIAL AND METHODS: Between January 2008 and December 2013, we retrospectively analyzed 225 consecutive hospitalized patients managed for endoscopically confirmed UGIH. RESULTS: A total of 225 patients (mean age 61...
November 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27209082/not-just-a-matter-of-size-a-hospital-level-risk-factor-analysis-of-mrsa-bacteraemia-in-scotland
#18
Cheryl L Gibbons, Bram A D van Bunnik, Oliver Blatchford, Chris Robertson, Thibaud Porphyre, Laura Imrie, Julie Wilson, J Ross Fitzgerald, Mark E J Woolhouse, Margo E Chase-Topping
BACKGROUND: Worldwide, there is a wealth of literature examining patient-level risk factors for methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia. At the hospital-level it is generally accepted that MRSA bacteraemia is more common in larger hospitals. In Scotland, size does not fully explain all the observed variation among hospitals. The aim of this study was to identify risk factors for the presence and rate of MRSA bacteraemia cases in Scottish mainland hospitals. Specific hypotheses regarding hospital size, type and connectivity were examined...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27184638/outcome-of-acute-upper-gastrointestinal-bleeding-in-patients-with-coronary-artery-disease-a-matched-case-control-study
#19
Kessarin Thanapirom, Wiriyaporn Ridtitid, Rungsun Rerknimitr, Rattikorn Thungsuk, Phadet Noophun, Chatchawan Wongjitrat, Somchai Luangjaru, Padet Vedkijkul, Comson Lertkupinit, Swangphong Poonsab, Thawee Ratanachu-Ek, Piyathida Hansomburana, Bubpha Pornthisarn, Thirada Thongbai, Varocha Mahachai, Sombat Treeprasertsuk
BACKGROUND/AIM: The risk of upper gastrointestinal bleeding (UGIB) increases in patients with coronary artery disease (CAD) due to the frequent use of antiplatelets. There is some data reporting on treatment outcomes in CAD patients presenting with UGIB. We aim to determine the clinical characteristics and outcomes of UGIB in patients with CAD, compared with non-CAD patients. PATIENTS AND METHODS: We conducted a prospective multi-center cohort study (THAI UGIB-2010) that enrolled 981 consecutive hospitalized patients with acute UGIB...
May 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27156655/use-of-capsule-endoscopy-in-the-emergency-department-as-a-triage-of-patients-with-gi-bleeding
#20
Joseph J Y Sung, Raymond S Y Tang, Jessica Y L Ching, Timothy H Rainer, James Y W Lau
BACKGROUND AND AIMS: Upper GI bleeding (UGIB) still constitutes one of the major hospital admissions through emergency departments (EDs). This feasibility study aims to test whether capsule endoscopy (CE) can reduce unnecessary hospital admissions in patients with suspected UGIB. METHODS: This was a prospective randomized controlled trial in which patients who presented with symptoms or signs suggestive of UGIB were randomized to receive either the standard treatment (ST) of hospital management or receive CE, after which hospital admission was determined by the findings of CE...
December 2016: Gastrointestinal Endoscopy
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