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https://www.readbyqxmd.com/read/29790230/visualizing-the-quantile-survival-time-difference-curve
#1
Harald Heinzl, Martina Mittlboeck
The difference between the pth quantiles of 2 survival functions can be used to compare patients' survival between 2 therapies. Setting p = 0.5 yields the median survival time difference. Varying p between 0 and 1 defines the quantile survival time difference curve which can be straightforwardly estimated by the horizontal differences between 2 Kaplan-Meier curves. The estimate's variability can be visualized by adding either a bundle of resampled bootstrap step functions or, alternatively, approximate bootstrap confidence bands...
May 23, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29790225/can-cardiovascular-mri-be-used-to-more-definitively-characterize-cardiac-masses-initially-identified-using-echocardiography
#2
Vikas K Rathi, Anna T Czajka, Diane V Thompson, Mark Doyle, Tarun Tewatia, June Yamrozik, Ronald B Williams, Robert W W Biederman
In diagnosing cardiac and paracardiac masses, cardiac MRI (CMR) has gained acceptance as the gold standard. CMR has been observed to be superior to echocardiography in characterizing soft-tissue structures and, specifically, in classifying cardiac masses. The aim of our study was to evaluate the association between mortality and cardiac or paracardiac masses initially identified by echocardiography (ECHO) and confirmed by CMR. Between January 2002 and August 2007, a total of 158 patients underwent both ECHO and CMR for the evaluation of cardiac masses that were equivocal or undefined by ECHO...
May 2018: Echocardiography
https://www.readbyqxmd.com/read/29790102/classification-of-malignant-and-benign-lung-nodules-using-taxonomic-diversity-index-and-phylogenetic-distance
#3
Robherson Wector de Sousa Costa, Giovanni Lucca França da Silva, Antonio Oseas de Carvalho Filho, Aristófanes Corrêa Silva, Anselmo Cardoso de Paiva, Marcelo Gattass
Lung cancer presents the highest cause of death among patients around the world, in addition of being one of the smallest survival rates after diagnosis. Therefore, this study proposes a methodology for diagnosis of lung nodules in benign and malignant tumors based on image processing and pattern recognition techniques. Mean phylogenetic distance (MPD) and taxonomic diversity index (Δ) were used as texture descriptors. Finally, the genetic algorithm in conjunction with the support vector machine were applied to select the best training model...
May 23, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29789824/layered-double-hydroxide-poly-dopamine-composite-coating-with-surface-heparinization-on-mg-alloys-improved-anticorrosion-endothelialization-and-hemocompatibility
#4
Hua Li, Feng Peng, Donghui Wang, Yuqin Qiao, Demin Xu, Xuanyong Liu
Magnesium (Mg) and its alloys are promising cardiovascular stent materials due to their favourable physical properties and complete degradation in vivo. However, rapid degradation and poor cytocompatibility hinder their clinical applications. To enhance the corrosion resistance and endothelialization of the AZ31 alloy, a layered double hydroxide (LDH)/poly-dopamine (PDA) composite coating (LDH/PDA) was successfully fabricated. Polarization curves and the electrochemical impedance spectroscopy Nyquist spectrum test proved that the corrosion resistance of the LDH/PDA sample was significantly improved in vitro...
May 23, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29789422/machine-learning-based-radiomics-for-molecular-subtyping-of-gliomas
#5
Chia-Feng Lu, Fei-Ting Hsu, Kevin Li-Chun Hsieh, Yu-Chieh Jill Kao, Sho-Jen Cheng, Justin Bo-Kai Hsu, Ping-Huei Tsai, Ray-Jade Chen, Chao-Ching Huang, Yun Yen, Cheng-Yu Chen
PURPOSE: The new classification announced by the World Health Organization in 2016 recognized five molecular subtypes of diffuse gliomas based on isocitrate dehydrogenase (IDH) and 1p/19q genotypes in addition to histological phenotypes. We aim to determine whether clinical magnetic resonance imaging (MRI) can stratify these molecular subtypes to benefit the diagnosis and monitoring of gliomas. EXPERIMENTAL DESIGN: The data from 456 subjects with gliomas were obtained from The Cancer Imaging Archive...
May 22, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29788739/identification-of-recurrent-risk-related-genes-and-establishment-of-support-vector-machine-prediction-model-for-gastric-cancer
#6
B Liu, J Tan, X Wang, X Liu
This study sought to investigate genes related to recurrent risk and establish a support vector machine (SVM) classifier for prediction of recurrent risk in gastric cancer (GC).Based on the gene expression profiling dataset GSE26253, feature genes that were significantly associated with survival time and status were screened out. Subsequently, protein-protein interaction (PPI) network was constructed for these feature genes, and genes in this network was optimized using betweenness centrality algorithm in order to identify genes potentially correlated with GC (named as GCGs)...
March 14, 2018: Neoplasma
https://www.readbyqxmd.com/read/29788736/evaluation-of-overall-survival-rate-of-different-therapies-in-the-treatment-of-t1-t3-prostate-cancer-a-network-meta-analysis
#7
S Y Chen, Y Du, Q Shao, J S Li, H Y Chen
We performed this network meta-analysis (NMA) in order to compare the overall survival rate of six different therapies of T1-T3 prostate cancer (PC). The therapies include radiotherapy (RT), endocrine therapy (ET), Cryoablation (CRYO), radical prostatectomy (RP), RT+ET and RP+ET. Pubmed, Embase, Cochrane Library, Google Scholar, Web of Science and MEDLINE were searched to collect relevant literature from the inception of the study till February 2017. Cohort studies meeting the inclusion criteria were included in the study...
March 14, 2018: Neoplasma
https://www.readbyqxmd.com/read/29788730/afp-role-in-predicting-recurrence-of-hepatocellular-carcinoma-after-living-donor-liver-transplantation-in-hcv-patients
#8
A Lech Komorowski, C C Hsu, K D Julka, B Vasavada, C C Lin, C C Wang, C L Chen
HCC is one of the leading causes of death worldwide. Liver transplantation including living donor transplantation is the best available treatment. We have analyzed our experience with LDLT in patients with HCC and HCV in order to determine if alpha feto-protein (AFP) is a better predictor of recurrence than the tumor burden. We have identified all patients with HCV related liver disease and HCC who have undergone LDLT in one center during the period from December 2000 to December 2014. Outcomes from the prospective database were compared for patients who met Milan criteria (single tumor ≤5 cm, maximum of 3 total tumors with none >3 cm) or not...
March 14, 2018: Neoplasma
https://www.readbyqxmd.com/read/29788014/persistently-increased-resting-energy-expenditure-predicts-short-term-mortality-in-patients-with-acute-on-chronic-liver-failure
#9
Jia Yao, Xiaoshuang Zhou, Hui Wang, Lili Yuan, Yu Chen, Zhongping Duan
OBJECTIVE: Hypermetabolism based on measurements of resting energy expenditure (REE) is suggested to be a potential biomarker for predicting the clinical outcomes of some diseases. We aimed to evaluate the potential value of hypermetabolism for predicting the short-term (28-day) mortality of patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). METHODS: A total of 105 HBV-ACLF patients, 30 chronic hepatitis B (CHB) patients and 30 healthy controls (HCs) were included in this study...
May 22, 2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29787596/survival-and-predictors-of-mortality-among-children-co-infected-with-tuberculosis-and-human-immunodeficiency-virus-at-university-of-gondar-comprehensive-specialized-hospital-northwest-ethiopia-a-retrospective-follow-up-study
#10
Kendalem Asmare Atalell, Nigusie Birhan Tebeje, Daniale Tekelia Ekubagewargies
BACKGROUND: Tuberculosis (TB) is the leading cause of death in Human immunodeficiency virus (HIV) infected children globally. The aims of this study were to determine the mortality rate and to identify the predictors of mortality among TB/HIV co-infected children at University of Gondar Comprehensive Specialized Hospital. METHOD: A retrospective follow-up study was conducted among TB/HIV co-infected children from February 2005 to March 2017. A Kaplan-Meier curve was used to estimate the median survival time...
2018: PloS One
https://www.readbyqxmd.com/read/29786546/flt3-itd-compared-with-dnmt3a-r882-mutation-is-a-more-powerful-independent-inferior-prognostic-factor-in-adult-aml-patients-after-allogeneic-hematopoietic-stem-cell-transplantation-a-retrospective-cohort-study
#11
Majid Teremmahi Ardestani, Ahmad Kazemi, Bahram Chahardouli, Saeed Mohammadi, Mohsen Nikbakht, Shahrbano Rostami, Mahdi Jalili, Mohammad Vaezi, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
OBJECTIVE: To identify DNMT3A exon 23 mutations and their prognostic impact in the presence of FLT3-ITD and NPM1 mutations in acute myeloid leukemia (AML) patients treated with Allo-HSCT. MATERIALS AND METHODS: This study analyzed128 adult AML patients referred to the Hematology-Oncology & Stem Cell Research Center of Shariati hospital. FLT3-ITD and NPM1 mutations were detected using fragment analysis. For DNMT3A exon 23 mutation analysis, we used Sanger sequencing...
May 22, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29786487/diffusion-weighted-mri-is-superior-to-pet-ct-in-predicting-survival-of-patients-undergoing-90-y-radioembolization-of-hepatic-metastases
#12
Alexandra Barabasch, Alexander Heinzel, Philipp Bruners, Nils A Kraemer, Christiane K Kuhl
Purpose To determine the relationship between diffusion-weighted (DW) liver MR images obtained 4-6 weeks after lobar yttrium 90 (90 Y) treatment and overall survival in comparison with PET/CT or established oncologic factors known to affect survival. Materials and Methods The institutional review board approved this prospective intraindividual comparative study in 36 consecutive patients (25 women) with liver-dominant metastases (20 colorectal, 14 breast, two other) (mean age, 60 years ± 10 [standard deviation]) who underwent fluorine 18 (18 F) fluorodeoxyglucose (FDG) PET/CT and DW MRI before and 4-6 weeks after 90 Y radioembolization...
May 21, 2018: Radiology
https://www.readbyqxmd.com/read/29786406/mitroflow-lxa-structural-deterioration-following-aortic-valve-replacement-a-single-centre-experience
#13
Kostantinos Zannis, Konstantinos Diplaris, Jean-Luc Monin, Nizar Khelil, Mathieu Debauchez, Patrice Dervanian, Emmanuel Lansac, Daniel Czirom, Milena Noghin, Leila Mankoubi, Nicolas Amabile
BACKGROUND: Concerns have been previously raised regarding the potential early degenera- tion of the Mitroflow (Sorin, Italy) bioprostheses. We aimed to evaluate our clinical experience with the Mitroflow LXA prosthesis for aortic valve replacement. METHODS: We prospectively analyzed data from 227 consecutive patients (133 males, mean age 73.9± 9.2 y ) implanted with the Mitroflow LXA between February 2007 and October 2011. Follow up data were obtained by contacting the referring cardiologists...
May 22, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29785861/prognostic-importance-of-albumin-to-globulin-ratio-in-metastatic-gastric-cancer-patients
#14
Yakup Bozkaya, Gökmen Umut Erdem, Nebi Serkan Demirci, Ozan Yazıcı, Nuriye Yıldırım Özdemir, Osman Köstek, Nurullah Zengin
AIM: The aim of this study was to evaluate the prognostic importance of albumin to globulin ratio (AGR) in terms of overall survival (OS) and progression free survival (PFS) in metastatic gastric cancer patients. METHODS: The patients diagnosed with metastatic gastric cancer between 2009 and April 2016 at our hospital have been studied retrospectively. The clinicopathological characteristics, laboratory and treatment parameters have been assessed. AGR value has been calculated using the following formula (AGR = serum albumin/total protein-serum albumin)...
May 22, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29785696/case-matched-comparison-of-long-term-functional-and-quality-of-life-outcomes-following-laparoscopic-versus-open-ileal-pouch-anal-anastomosis
#15
Olga A Lavryk, Luca Stocchi, Jean H Ashburn, Meagan Costedio, Emre Gorgun, Tracy L Hull, Hermann Kessler, Conor P Delaney
BACKGROUND: Laparoscopic ileal pouch-anal anastomosis (IPAA) is associated with recovery benefits when compared with open IPAA. There is limited data on long-term quality of life and functional outcomes, which this study aimed to assess. METHODS: An IRB-approved, prospectively maintained database was queried to identify patients undergoing laparoscopic IPAA (L), case-matched with open IPAA (O) based on age ± 5 years, gender, body mass index (BMI) ± 5 kg/m2 , diagnosis, date of surgery ± 3 years, stapled/handsewn anastomosis, omission of diverting loop ileostomy and length of follow-up ± 3 years...
May 21, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29785446/digital-droplet-pcr-based-absolute-quantification-of-pre-transplant-npm1-mutation-burden-predicts-relapse-in-acute-myeloid-leukemia-patients
#16
Marius Bill, Juliane Grimm, Madlen Jentzsch, Laura Kloss, Karoline Goldmann, Julia Schulz, Stefanie Beinicke, Janine Häntschel, Michael Cross, Vladan Vucinic, Wolfram Pönisch, Gerhard Behre, Georg-Nikolaus Franke, Thoralf Lange, Dietger Niederwieser, Sebastian Schwind
Allogeneic hematopoietic stem cell transplantation is an established consolidation therapy for patients with acute myeloid leukemia. However, relapse after transplantation remains a major clinical problem resulting in poor prognosis. Thus, detection of measurable ("minimal") residual disease to identify patients at high risk of relapse is essential. A feasible method to determine measurable residual disease may be digital droplet PCR (ddPCR) that allows absolute quantification with high sensitivity and specificity without the necessity of standard curves...
May 22, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29785275/infant-activity-and-sleep-behaviors-in-a-maternal-and-infant-home-visiting-project-among-rural-southern-african-american-women
#17
Jessica L Thomson, Lisa M Tussing-Humphreys, Melissa H Goodman, Alicia S Landry
Background: Physical inactivity and inadequate amounts of sleep are two potential causes for excessive weight gain in infancy. Thus, parents and caregivers of infants need to be educated about decreasing infant sedentary behavior, increasing infant unrestrained floor time, as well as age specific recommended amounts of sleep for infants. The aims of this study were to determine if maternal knowledge about infant activity and sleep changed over time and to evaluate maternal compliance rates with expert recommendations for infant sleep in a two-arm, randomized, controlled, comparative impact trial...
2018: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/29784845/interaction-of-bacterial-phenazines-with-colistimethate-in-bronchial-epithelial-cells
#18
Valeri V Mossine, Deborah L Chance, James K Waters, Thomas P Mawhinney
Multidrug-resistant bacterial infections are being increasingly treated in clinics with polymyxins, a class of antibiotics associated with adverse effects in the kidney, nervous system, or airways of a significant proportion of human and animal patients. Although many of the resistant pathogens display enhanced virulence, a hazard of cytotoxic interactions between polymyxin antibiotics and bacterial virulence factors (VFs) has not been assessed, to date. We report here on testing paired combinations of four Pseudomonas aeruginosa VF phenazine toxins, pyocyanin (PYO), 1-hydroxyphenazine (1-HP), phenazine-1-carboxylic acid (PCA), phenazine-1-carboxamide (PCN), and two commonly prescribed polymyxin drugs, colistimethate (CMS)/colistin and polymyxin B, in three human airway cell lines, BEAS-2B, HBE-1, and CFT-1...
May 21, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29784506/predicting-prognosis-in-resected-esophageal-squamous-cell-carcinoma-using-a-clinical-nomogram-and-recursive-partitioning-analysis
#19
Yuzhen Zheng, Shenshen Fu, Tiancheng He, Qihang Yan, Wenyu Di, Junye Wang
BACKGROUND: Development demand of precise medicine in resectable esophageal squamous cell carcinoma (ESCC) require to recognize patients at high risk treated by surgery alone. Thus, our aim was to construct a clinical nomogram and recursive partitioning analysis (RPA) to predict long-term survival in ESCC treated by surgery alone. METHODS: Based on the patients with ESCC who treated by three-incisional esophagectomy and two-field lymphadenectomy alone, we identified and integrated significant prognostic factors for survival to build a nomogram...
April 24, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29784063/protein-coding-genes-combined-with-long-noncoding-rna-as-a-novel-transcriptome-molecular-staging-model-to-predict-the-survival-of-patients-with-esophageal-squamous-cell-carcinoma
#20
Jin-Cheng Guo, Yang Wu, Yang Chen, Feng Pan, Zhi-Yong Wu, Jia-Sheng Zhang, Jian-Yi Wu, Xiu-E Xu, Jian-Mei Zhao, En-Min Li, Yi Zhao, Li-Yan Xu
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is the predominant subtype of esophageal carcinoma in China. This study was to develop a staging model to predict outcomes of patients with ESCC. METHODS: Using Cox regression analysis, principal component analysis (PCA), partitioning clustering, Kaplan-Meier analysis, receiver operating characteristic (ROC) curve analysis, and classification and regression tree (CART) analysis, we mined the Gene Expression Omnibus database to determine the expression profiles of genes in 179 patients with ESCC from GSE63624 and GSE63622 dataset...
April 9, 2018: Cancer communications
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