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https://www.readbyqxmd.com/read/28680838/utility-of-electronic-medical-record-based-fibrosis-scores-in-predicting-advanced-cirrhosis-in-patients-with-hepatitic-c-virus-infection
#1
Mohammad Qasim Khan, Vijay Anand, Norbert Hessefort, Ammar Hassan, Alya Ahsan, Amnon Sonnenberg, Claus J Fimmel
OBJECTIVE: To determine whether advanced cirrhosis - defined by the detection of nodular liver contours or portal venous collaterals on imaging studies - could be predicted by fibrosis algorithms, calculated using laboratory and demographic features extracted from patients' electronic medical records. To this end, we compared seven EMR-based fibrosis scores with liver imaging studies in a cohort of HCV patients. METHODS: A search of our health system's patient data warehouse identified 867 patients with chronic HCV infection...
March 2017: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/28489180/does-infection-by-the-hepatitis-c-virus-decrease-the-response-of-immunization-against-the-hepatitis-b-virus-in-individuals-undergoing-dialysis
#2
Tarcila Maria Bonfim Ferreira, Tácio Giordano Santana Guimarães, Andrea Martins Melo Fontenele, Natalino Salgado, Adalgisa de Souza Paiva Ferreira, Alessandra Porto de Macedo Costa
Introduction: Vaccination is the most effective tool in preventing transmission of Hepatitis B Virus (HBV). The patient with chronic kidney disease (CKD) on dialysis appear to be at greater risk of becoming infected with this virus and does not show the same vaccine response when compared to patients without uremia. Objectives: To evaluate the results related to the HBV vaccine and identify factors associated with the response in patients with CKD on hemodialysis...
April 27, 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/28489174/the-impact-of-the-meld-score-on-liver-transplant-allocation-and-results-an-integrative-review
#3
Ana Claudia Oliveira de Moraes, Priscilla Caroliny de Oliveira, Olival Cirilo Lucena da Fonseca-Neto
Introduction: Liver transplantation is intended to increase the survival of patients with chronic liver disease in terminal phase, as well as improved quality of life. Since the first transplant until today many changes have occurred in the organ allocation system. Objective: To review the literature on the Model for End-stage Liver Disease (MELD) and analyze its correlation with survival after liver transplantation. Method: An integrative literature review in Lilacs, SciELO, and Pubmed in October 2015, was realized...
January 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28299974/causes-of-peripheral-cytopenia-in-hepatitic-cirrhosis-and-portal-hypertensive-splenomegaly
#4
Yunfu Lv, Wan Yee Lau, Hongfei Wu, XiaoYu Han, Xiaoguang Gong, Ning Liu, Jie Yue, Qingqing Li, YeJuan Li, Jie Deng
The clinical data of 183 patients with hepatitic cirrhosis and portal hypertensive splenomegaly complicated by peripheral cytopenia were retrospectively analyzed to investigate the causes of peripheral cytopenia, as well as the proportion of the causes in these patients. All patients underwent splenectomy. Before operation, these patients had one or more types of peripheral cytopenia (cumulative cytopenia: 390 patient-times). After splenectomy, blood counts in 79.2% (309/390) returned to normal, while in 15...
April 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28076482/correlation-of-non-alcoholic-fatty-liver-disease-and-features-of-metabolic-syndrome-in-morbidly-obese-patients-in-the-preoperative-assessment-for-bariatric-surgery
#5
COMPARATIVE STUDY
Fernando de Barros, Sergio Setúbal, José Manoel Martinho, Loraine Ferraz, Andressa Gaudêncio
Background: Obesity is an epidemic and chronic disease that can bring other comorbidities to the patient. Non-alcoholic fatty liver disease is present in up to 90% of these patients and can progress to hepatitis and hepatocarcinoma. The relationship of this liver disease and obesity is already well known; however, it is possible that some parameters of the comorbidities are more related than others in the pathophysiology of the disease. Aim: Was analyzed the relationship between non-alcoholic fatty liver disease (NAFLD) and the comorbidities of metabolic syndrome in morbidly obese patients...
November 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27829381/seroprevalence-of-hepatitis-c-virus-among-people-living-with-hiv-aids-in-latin-america-and-the-caribbean-a-systematic-review
#6
REVIEW
Fatima Mitiko Tengan, Karim Yakub Ibrahim, Bianca Peixoto Dantas, Caroline Manchiero, Mariana Cavalheiro Magri, Wanderley Marques Bernardo
BACKGROUND: Studies have shown that the immunosuppression induced by the human immunodeficiency virus (HIV) accelerates the natural history of liver disease associated with hepatitis C virus (HCV), with 3- to 5-fold higher odds of coinfected individuals developing cirrhosis. However, estimates of the seroprevalence of hepatitis C among people living with HIV/acquired immune deficiency syndrome (AIDS) (PLHA) in Latin America and the Caribbean (LAC) are widely variable. METHODS: We performed a systematic review to estimate the seroprevalence of HCV among PLHA...
November 9, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27625202/prevalence-of-and-factors-associated-with-depression-among-people-living-with-hiv-in-france
#7
P Feuillet, F Lert, L Tron, C Aubriere, B Spire, R Dray-Spira
OBJECTIVES: Depression is common among people living with HIV (PLWHIV) and is associated with poorer therapeutic outcomes and risky behaviours. We sought to estimate the prevalence of major depressive episode (MDE) across PLWHIV groups, to compare this with its prevalence in the general population and to assess factors associated with it. METHODS: We used data from the Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS)-Vespa2 study, a national study on a representative sample of PLWHIV conducted in France in 2011...
September 14, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27479232/mait-be-different-persisting-dysfunction-after-daa-mediated-clearance-of-chronic-hepatitis-c-virus-infection
#8
Maike Hofmann, Robert Thimme
MAIT cells are an abundant innate-like T-cell subset that is defined by the invariant T-cell receptor (iTCR) V-alpha chain Vα7.2-Jα33. Little is currently known about their frequency and function in chronic hepatitis C virus (HCV) infection and their fate after therapy-mediated HCV elimination by direct acting antivirals (DAA). In this issue of the European Journal of Immunology, Hengst et al. [Eur. J. Immunol. 2016. 46: 2204-2210] give important novel insights into the biological role of MAIT cells in a relevant human chronic viral infection by showing that first, MAIT cells are only present at low frequencies in chronic HCV infection; second, circulating MAIT cells in HCV patients also display an altered phenotype; third, they are impaired in their MR-1-dependent effector functions and finally, and maybe most importantly, MAIT-cell frequency and function was not restored after HCV elimination by DAA therapy...
September 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27476823/molecular-mechanisms-of-hepatitis-c-virus-induced-hepatocellular-carcinoma
#9
REVIEW
T Vescovo, G Refolo, G Vitagliano, G M Fimia, M Piacentini
Hepatitis C virus (HCV) is a major leading cause of hepatocellular carcinoma (HCC). HCV-induced hepatocarcinogenesis is a multistep process resulting from a combination of pathway alterations that are either caused directly by viral factors or immune mediated as a consequence of a chronic state of inflammation. Host genetic variation is now emerging as an additional element that contribute to increase the risk of developing HCC. The advent of direct-acting antiviral agents foresees a rapid decline of HCC rate in HCV patients...
October 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27453412/the-correlation-analysis-of-primary-liver-cancer-with-type-2-diabetes
#10
Q Su, F Sun, J Li, H Zhang, M Wang, H Zhou, L Qiao
OBJECTIVE: To explore the relationship between Type 2 diabetes and primary liver cancer. MATERIALS AND METHODS: In the period from December 2008 to December 2014, all blood sugar data of patients in our hospital was collected, and the total number is 18213. Except for repeatedly hospitalized diabetic person, newborn stress status, or venous transfusion blood glucose, gestational diabetes, etc., By retrieving the medical record information of patients in the hospital, and using telephone or letter follow-up the patients, we collected 127 people with type 1 diabetes and found no liver cancer patients; Type 2 diabetes, 10,794 cases of patient information, 59 with primary liver cancer...
December 2015: Indian Journal of Cancer
https://www.readbyqxmd.com/read/27419677/-health-related-quality-of-life-in-patients-with-hepatitis-c-treated-with-dual-and-triple-therapy
#11
Raíssa Neves Fagundes, Lincoln Eduardo Villela Vieira de Castro Ferreira, Fábio Heleno de Lima Pace
OBJECTIVE: Comparing Health-Related Quality of Life (HRQoL) scores in patients with chronic hepatitis C undergoing double and triple antiviral therapy and analyzing possible factors related to HRQoL. METHOD: HRQoL was assessed using the Short Form 36 and Chronic Liver Disease Questionnaire, which were applied at baseline and at weeks 4, 12 and 16 of treatment to 32 patients divided into two groups: double therapy with pegylated interferon (IFN-PEG) and ribavirin, and triple therapy with PEG-IFN, ribavirin and telaprevir...
December 2015: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/27234582/hepatocellular-carcinoma-incidentally-detected-at-second-hepatectomy-for-repeated-colorectal-liver-metastasis-in-a-patient-with-hepatitis-c-virus-related-cirrhosis-a-case-report
#12
Atsuo Kobayashi, Daisuke Morioka, Chizuru Matsumoto, Yasuhiko Miura, Masaru Miura
BACKGROUND: It has been reported that liver metastasis rarely occurs in a cirrhotic/hepatitic liver. Thus, coexistence of liver metastasis and hepatocellular carcinoma has been scarcely reported. To the best of our knowledge, there are no cases with hepatocellular carcinoma, which developed during an observational period after hepatectomy for colorectal liver metastasis, in the worldwide English literature. Here we present a case of hepatocellular carcinoma which occurred during a period between the first and second hepatectomy for repeated colorectal liver metastasis...
May 27, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27212241/delisting-of-liver-transplant-candidates-with-chronic-hepatitis-c-after-viral-eradication-a-european-study
#13
Luca Saverio Belli, Marina Berenguer, Paolo Angelo Cortesi, Mario Strazzabosco, Susanne-Rasoul Rockenschaub, Silvia Martini, Cristina Morelli, Francesca Donato, Riccardo Volpes, Georges-Philippe Pageaux, Audrey Coilly, Stefano Fagiuoli, Giuliana Amaddeo, Giovanni Perricone, Carmen Vinaixa, Gabriela Berlakovich, Rita Facchetti, Wojciech Polak, Paolo Muiesan, Christophe Duvoux
BACKGROUND & AIMS: All oral direct acting antivirals (DAA) have been shown to improve the liver function of patients with decompensated cirrhosis but it is presently unknown whether this clinical improvement may lead to the delisting of some patients. The aim of this study was to assess if and which patients can be first inactivated due to clinically improvement and subsequently delisted in a real life setting. METHODS: 103 consecutive listed patients without hepatocellular carcinoma were treated with different DAA combinations in 11 European centres between February 2014 and February 2015...
September 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27187027/psychiatric-and-substance-use-disorders-in-hiv-hepatitis-c-virus-hcv-coinfected-patients-does-hcv-clearance-matter-agence-nationale-de-recherche-sur-le-sida-et-les-h%C3%A3-patites-virales-anrs-hepavih-co13-cohort
#14
L Michel, C Lions, M Winnock, J-P Lang, M-A Loko, E Rosenthal, B Marchou, M-A Valantin, P Morlat, P Roux, P Sogni, B Spire, I Poizot-Martin, K Lacombe, C Lascoux-Combe, C Duvivier, D Neau, F Dabis, D Salmon-Ceron, M P Carrieri
OBJECTIVES: The objective of this nested study was to assess the prevalence of psychiatric disorders in a sample of HIV/hepatitis C virus (HCV)-coinfected patients according to their HCV status. METHODS: The nested cross-sectional study, untitled HEPAVIH-Psy survey, was performed in a subset of HIV/HCV-coinfected patients enrolled in the French Agence Nationale de Recherche sur le SIDA et les Hépatites Virales (ANRS) CO13 HEPAVIH cohort. Psychiatric disorders were screened for using the Mini International Neuropsychiatric Interview (MINI 5...
November 2016: HIV Medicine
https://www.readbyqxmd.com/read/27128845/molecular-assessment-of-vitamin-d-receptor-polymorphism-as-a-valid-predictor-to-the-response-of-interferon-ribavirin-based-therapy-in-egyptian-patients-with-chronic-hepatitis-c
#15
Ahmed Abdelsalam, Laila Rashed, Tarek Salman, Lamiaa Hammad, Dina Sabry
OBJECTIVE: The aim of this study was to find an association between serum concentration of vitamin D and vitamin D receptor (VDR) polymorphisms to achieve a sustained virological response (SVR). METHODS: We conducted a case-control study in which 250 participants were recruited and divided into three groups (100 chronic hepatitis C [CHC] patients who achieved SVR, 100 CHC patients who did not achieve SVR and 50 apparently healthy individuals as controls). Blood samples were collected to measure serum vitamin D concentration, and four VDR polymorphisms (FokI, ApaI, TaqI, and BsmI) were detected using polymerase chain reaction-restriction fragment length polymorphism...
August 2016: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/26968010/comparison-of-therapeutic-response-and-clinical-outcome-between-hcv-patients-with-normal-and-abnormal-alanine-transaminase-levels
#16
COMPARATIVE STUDY
Cheng-Kung Wu, Kuo-Chin Chang, Po-Lin Tseng, Sheng-Nan Lu, Chien-Hung Chen, Jing-Houng Wang, Chuan-Mo Lee, Ming-Tsung Lin, Yi-Hao Yen, Chao-Hung Hung, Tsung-Hui Hu
BACKGROUND AND AIMS: Patients with chronic hepatitic C (HCV) infection and normal serum alanine transaminase (ALT) levels were considered to have mild disease. In Taiwan, these patients were not suggested for interferon (IFN) based therapies. The aim of study is to compare therapeutic outcomes between HCV patients with normal and elevated ALT levels. METHODS: We conducted a retrospective study on 3241 HCV patients treated by IFN based therapies. Patients with normal ALT levels were classified as group A (n = 186) while those with elevated ALT levels were group B (n = 3055)...
2016: PloS One
https://www.readbyqxmd.com/read/26762993/hiv-1-virological-remission-lasting-more-than-12-years-after-interruption-of-early-antiretroviral-therapy-in-a-perinatally-infected-teenager-enrolled-in-the-french-anrs-epf-co10-paediatric-cohort-a-case-report
#17
Pierre Frange, Albert Faye, Véronique Avettand-Fenoël, Erianna Bellaton, Diane Descamps, Mathieu Angin, Annie David, Sophie Caillat-Zucman, Gilles Peytavin, Catherine Dollfus, Jerome Le Chenadec, Josiane Warszawski, Christine Rouzioux, Asier Sáez-Cirión
BACKGROUND: Durable HIV-1 remission after interruption of combined antiretroviral therapy (ART) has been reported in some adults who started treatment during primary infection; however, whether long-term remission in vertically infected children is possible was unknown. We report a case of a young adult perinatally infected with HIV-1 with viral remission despite long-term treatment interruption. METHODS: The patient was identified in the ANRS EPF-CO10 paediatric cohort among 100 children infected with HIV perinatally who started ART before 6 months of age...
January 2016: Lancet HIV
https://www.readbyqxmd.com/read/26534641/a-hepatite-c-cr%C3%A3-nica-diminui-a-qualidade-de-vida
#18
C M Perlin, H H Borba, L F Wzorek, T Piazza, C Madeira, R Pontarolo, A Wiens
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/26534639/custo-efetividade-do-tenofovir-para-o-tratamento-da-hepatite-b-cr%C3%A3-nica-uma-revis%C3%A3-o-sistem%C3%A3-tica
#19
J C Balbinot, A Wiens, R Pontarolo, A C Sanches
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/26281177/-immunogenetics-and-progression-of-chronic-viral-hepatites
#20
E V Beloborodova, I A Goncharova, E I Beloborodova, I L Purlik, T P Kalacheva, O E Akbasheva, M I Rachkovskiy, V A Burkovskaya
AIM OF INVESTIGATION: To estimate the role of polymorphic variants of genes IL4 (C-590T), IL4RA (I50V), TNF (G-308A) and SLC1IAI (D543N) in chronic viral hepatitis progression. MATERIAL AND METHODS: Overall 121 patients with chronic viral hepatitis C and B. RESULTS: Study results have demonstrated, that of all investigated polymorphic variants of genes IL4 (C-590T), IL4RA (150V), TNF (G-308A) and SLC11A1 (D543N) in patients with chronic liver diseases of various etiology the <Val/Val> IL4RA gene variant (II50Val) is associated with HBV-infection chronization...
2015: Experimental & Clinical Gastroenterology
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