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Diabetic emergencies

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https://www.readbyqxmd.com/read/29666775/thenar-compartment-syndrome-what-if-a-compartment-pressure-measuring-device-is-absent
#1
Aydin Budeyri, Mehmet C Cankus, Gökhan Meric, Gökhan B Sever
Compartment syndrome (CS) is a threatening condition characterized by excessive tissue pressure accumulation associated with acute trauma. Compartment syndrome causes a significant reduction in blood flow with subsequent muscle and nerve ischemic necrosis. Recently, reports have described the importance of intramuscular pressure measurements as a basis for CS diagnosis. Unfortunately, the measuring devices that were utilized produced results with unsatisfactory reliability, making a diagnosis and subsequent treatment challenging...
February 16, 2018: Curēus
https://www.readbyqxmd.com/read/29663436/early-effects-of-empagliflozin-on-exercise-tolerance-in-patients-with-heart-failure-a-pilot-study
#2
Julio Núñez, Patricia Palau, Eloy Domínguez, Anna Mollar, Eduardo Núñez, Jose María Ramón, Gema Miñana, Enrique Santas, Lorenzo Fácila, Jose Luis Górriz, Juan Sanchis, Antoni Bayés-Genís
BACKGROUND: Sodium-glucose linked transporter 2 inhibition recently emerged as a promising therapy for reducing the risk of heart failure (HF) in patients with type 2 diabetes mellitus (T2DM). However, there is a lack of data endorsing its role in symptomatic HF patients. We sought to evaluate the short-term effects of empagliflozin on maximal exercise capacity in these patients. HYPOTHESIS: We postulate tretament with empagliflozin may improve functional capacity in patients with T2DM and established HF...
April 17, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29663121/the-beneficence-of-hope-findings-from-a-qualitative-study-with-gout-and-diabetes-patients
#3
Isabelle Wienand, Milenko Rakic, David Shaw, Bernice Elger
This paper explores the importance of hope as a determining factor for patients to participate in first-in-human trials for synthetic biology therapies. This paper focuses on different aspects of hope in the context of human health and well-being and explores the varieties of hope expressed by patients. The research findings are based on interview data collected from stable gout and diabetes patients. Three concepts of hope have emerged from the interviews: hope as certainty (H1); hope as reflective uncertainty (H2); hope as self-therapy (H3)...
April 16, 2018: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/29662887/characteristics-of-heat-illness-during-hajj-a-cross-sectional-study
#4
Doaa A Abdelmoety, Nahid K El-Bakri, Wedian O Almowalld, Zyad A Turkistani, Bassam H Bugis, Eshraq A Baseif, Mohamed H Melbari, Khaled AlHarbi, Amani Abu-Shaheen
Introduction: Data regarding the characteristics and outcomes of heat illness are lacking in the literature. The present study aimed to identify the clinical characteristics, morbidity, management, and mortality associated with heat illness among Hajj participants. Methods: A cross-sectional study was conducted during the Hajj in 2016 on patients who presented to emergency departments and were diagnosed with heat exhaustion or heatstroke. Data were collected using a structured collection sheet developed based on the literature...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29662328/hyporeninemic-hypoaldosteronism-in-a-patient-with-diabetes-mellitus-an-unforgettable-case-report
#5
Naziha Chelaghma, Samson O Oyibo
A 58-year-old man presented with a 3-year history of chronic and intermittent hyperkalemia requiring recurrent attendances to the emergency department for urgent treatment. His medical history included secondary diabetes mellitus following a bout of acute pancreatitis and a previous splenectomy for a spontaneous splenic rupture. He also had a history of prolonged use of non-steroidal anti-inflammatory drugs for back pain and painful neuropathy. He was not on any medication or diet that would cause a raised serum potassium level and his renal function was normal...
2018: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/29661697/cardiovascular-disease-risk-in-sexual-minority-women-18-59-years-old-findings-from-the-national-health-and-nutrition-examination-survey-2001-2012
#6
Billy A Caceres, Abraham A Brody, Perry N Halkitis, Caroline Dorsen, Gary Yu, Deborah A Chyun
OBJECTIVE: Sexual minority women (lesbian and bisexual) experience significant stigma, which may increase their cardiovascular disease (CVD) risk. The purpose of this study was to examine the prevalence of modifiable risk factors for CVD (including mental distress, health behaviors, blood pressure, glycosylated hemoglobin, and total cholesterol) and CVD in sexual minority women compared with their heterosexual peers. MATERIALS AND METHODS: A secondary analysis of the National Health and Nutrition Examination Survey (2001-2012) was conducted...
April 13, 2018: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29660786/activity-and-selectivity-cliffs-for-dpp-iv-inhibitors-lessons-we-can-learn-from-sar-studies-and-their-application-to-virtual-screening
#7
REVIEW
María José Ojeda-Montes, Aleix Gimeno, Sarah Tomas-Hernández, Adrià Cereto-Massagué, Raúl Beltrán-Debón, Cristina Valls, Miquel Mulero, Gerard Pujadas, Santiago Garcia-Vallvé
The inhibition of dipeptidyl peptidase-IV (DPP-IV) has emerged over the last decade as one of the most effective treatments for type 2 diabetes mellitus, and consequently (a) 11 DPP-IV inhibitors have been on the market since 2006 (three in 2015), and (b) 74 noncovalent complexes involving human DPP-IV and drug-like inhibitors are available at the Protein Data Bank (PDB). The present review aims to (a) explain the most important activity cliffs for DPP-IV noncovalent inhibition according to the binding site structure of DPP-IV, (b) explain the most important selectivity cliffs for DPP-IV noncovalent inhibition in comparison with other related enzymes (i...
April 16, 2018: Medicinal Research Reviews
https://www.readbyqxmd.com/read/29660213/role-of-ncor1-in-mitochondrial-function-and-energy-metabolism
#8
REVIEW
Tanes I Lima, Rafael R Valentim, Hygor N Araújo, André G Oliveira, Bianca C Favero, Eveline S Menezes, Rafaela Araújo, Leonardo R Silveira
Mitochondrial number and shape are constantly changing in response to increased energy demands. The ability to synchronize mitochondrial pathways to respond to energy fluctuations within the cell is a central aspect of mammalian homeostasis. This dynamic process depends on the coordinated activation of transcriptional complexes to promote the expression of genes encoding for mitochondrial proteins. Recent evidence has shown that the nuclear corepressor NCoR1 is an essential metabolic switch which acts on oxidative metabolism signaling...
April 16, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29660181/descriptive-versus-mechanistic-scientific-approach-to-study-wound-healing-and-its-inhibition-is-there-a-value-of-translational-research-involving-human-subjects
#9
REVIEW
Irena Pastar, Lulu Lu Wong, Andjela N Egger, Marjana Tomic-Canic
The clinical field of wound healing is challenged by numerous hurdles. Not only are wound healing disorders complex and multifactorial, but the corresponding patient population is diverse, often elderly and burdened by multiple comorbidities such as diabetes, cardiovascular disease, etc. The care of such patients requires a dedicated, multi-disciplinary team of physicians, surgeons, nurses, and scientists. In spite of the critical clinical need, it has been over 15 years since a treatment received approval for efficacy by the FDA in the United States...
April 16, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29659378/osteoimmunology-effects-of-standard-orthopaedic-interventions-on-inflammatory-response-and-early-fracture-healing
#10
Prism S Schneider, Emilie Sandman, Paul A Martineau
Achieving fracture union is highly dependent on the initial inflammatory phase of fracture healing, which is influenced by both the local and systemic inflammatory environments. The rapidly emerging field of osteoimmunology involves the study of the interactions between the immune system and the skeletal system. Recent research has advanced the current state of knowledge regarding the effects of the surrounding soft-tissue injury, fracture hematoma, and the method of fracture fixation on the inflammatory phase of fracture healing...
April 13, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29659365/-association-between-diabetic-ketoacidosis-and-acromegaly
#11
Paloma Ocampo, Juan Manuel Duarte, Ricardo Barcia, Cecilia Arévalo
Diabetes mellitus occurs in nearly 10% of patients with acromegaly and is secondary to insulin resistance caused by high levels of growth hormone. Diabetes ketoacidosis has been described as a rare complication of acromegaly, resulting from a relative insulin deficiency caused by growth hormone excess. We described the case of a 38 year-old man who presented to the emergency room with a 6-week history of polydipsia, polyuria, polyphagia and weight loss. He also had nausea, vomiting and abdominal pain from two days before admission...
2018: Medicina
https://www.readbyqxmd.com/read/29659358/-role-of-the-enterocyte-in-type-2-diabetes-mellitus-associated-dyslipidemia
#12
Cecilia I Closs, Martín A Ruiz Diaz, Alberto M Cafferata, Damasia Becú-Villalobos, Juan P Nogueira
In type 2 diabetes mellitus there is an overproduction of chylomicron in the postprandial state that is associated with increased cardiovascular risk. Current evidence points out a leading role of enterocyte in dyslipidemia of type 2 diabetes mellitus, since it increases the production of apolipoprotein B-48 in response to a raise in plasma free fatty acids and glucose. The chylomicron metabolism is regulated by many factors apart from ingested fat, including hormonal and metabolic elements. More recently, studies about the role of gut hormones, have demonstrated that glucagon-like peptide-1 decreases the production of apolipoprotein B-48 and glucagon-like peptide-2 enhances it...
2018: Medicina
https://www.readbyqxmd.com/read/29656387/a-nationwide-analysis-of-30-day-adverse-events-unplanned-readmission-and-length-of-hospital-stay-after-peripheral-nerve-surgery-in-extremities-and-the-brachial-plexus
#13
Enrico Martin, Ivo S Muskens, Joeky T Senders, David J Cote, Timothy R Smith, Marike L D Broekman
BACKGROUND: Little is known on adverse events and their timing after peripheral nerve surgery in extremities. The aim of this study is to identify predictors and typical timing of complications, unplanned readmission, and length of hospital stay for patients undergoing peripheral nerve surgery in the extremities. METHODS: Data were extracted from the National Surgical Quality Improvement Program (NSQIP) registry from 2005 to 2015. Adult patients undergoing peripheral nerve surgery in the extremities were included...
April 15, 2018: Microsurgery
https://www.readbyqxmd.com/read/29652731/obesity-and-cardiovascular-risk-a-call-for-action-from-the-european-society-of-hypertension-working-group-of-obesity-diabetes-and-the-high-risk-patient-and-european-association-for-the-study-of-obesity-part-b-obesity-induced-cardiovascular-disease-early-prevention
#14
Vasilios Kotsis, Konstantinos Tsioufis, Christina Antza, Gino Seravalle, Antonio Coca, Cristina Sierra, Empar Lurbe, Stella Stabouli, Bojan Jelakovic, Josep Redon, Pau Redon, Peter M Nilsson, Jens Jordan, Dragan Micic, Nicholas Finer, Deborah R Leitner, Hermann Toplak, Lale Tokgozoglu, Vasilios Athyros, Moses Elisaf, Theodosios D Filippatos, Guido Grassi
: Obesity predisposes for atrial fibrillation, heart failure, sudden cardiac death, renal disease and ischemic stroke, which are the main causes of cardiovascular hospitalization and mortality. As obesity and the cardiovascular effects on the vessels and the heart start early in life, even from childhood, it is important for health policies to prevent obesity very early before the disease manifestation emerge. Key roles in the prevention are strategies to increase physical exercise, reduce body weight and to prevent or treat hypertension, lipids disorders and diabetes earlier and efficiently to prevent cardiovascular complications...
April 12, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29652634/emerging-applications-of-genome-editing-technology-to-examine-functionality-of-gwas-associated-variants-for-complex-traits
#15
Andrew J P Smith, Panos Deloukas, Patricia B Munroe
Over the last decade, genome-wide association studies (GWAS) have propelled the discovery of thousands of loci associated with complex diseases. The focus is now turning towards the function of these association signals, determining the causal variant(s) amongst those in strong linkage disequilibrium, and identifying their underlying mechanisms, such as long-range gene regulation. Genome-editing techniques utilising zinc-finger nucleases (ZFN), transcription activator-like effector nucleases (TALENs) and clustered regularly-interspaced short palindromic repeats with Cas9 nuclease (CRISPR-Cas9), are becoming the tools of choice to establish functionality for these variants, due to the ability to assess effects of single variants in vivo...
April 13, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29652110/intranasal-glucagon-for-hypoglycaemia-in-diabetic-patients-an-old-dream-is-becoming-reality
#16
REVIEW
Antonio E Pontiroli, Valerio Ceriani
In 1983 it was shown that glucagon administered intranasally (IN) was absorbed through the nasal mucosa and increased blood glucose in healthy subjects. Shortly thereafter, it was shown that IN glucagon counteracts hypoglycaemia in insulin-treated diabetic patients. In spite of this evidence, IN glucagon has not been developed by any pharmaceutical company before 2010, when renewed interest led to intensive evaluation as a possible remedy for hypoglycaemia in insulin-treated diabetic adults and children. IN glucagon is now being developed as a needle-free device delivering glucagon powder for treating severe hypoglycaemia; the ease of using this device stands in stark contrast to the difficulties in preparing and injecting the current intramuscular glucagon emergency kits...
April 13, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29650082/hyperglycemic-emergencies-in-adults
#17
Jeannette Goguen, Jeremy Gilbert
No abstract text is available yet for this article.
April 2018: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29649917/association-of-obesity-with-healthcare-resource-utilization-and-costs-in-a-commercial-population
#18
Pravin S Kamble, Jennifer Hayden, Jenna Collins, Raymond A Harvey, Brandon Suehs, Andrew Renda, Mette Hammer, Joanna Huang, Jonathan Bouchard
OBJECTIVE: To examine the association of obesity with healthcare resource utilization (HRU) and costs among commercially insured individuals. METHODS: This retrospective observational cohort study used insured individuals' administrative claims from 1/1/2007 to 12/1/2013. The ICD-9-CM status codes (V85 hierarchy) from 2008 to 2012 classified body mass index (BMI) into the World Health Organizations' BMI categories. The date of first observed BMI code was defined as the index date and continuous eligibility for one year pre- and post- index date was ensured...
April 12, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29649334/urinary-cgmp-predicts-major-adverse-renal-events-in-patients-with-mild-renal-impairment-and-or-diabetes-mellitus-before-exposure-to-contrast-medium
#19
Lyubov Chaykovska, Fabian Heunisch, Gina von Einem, Carl-Friedrich Hocher, Oleg Tsuprykov, Mira Pavkovic, Peter Sandner, Axel Kretschmer, Chang Chu, Saban Elitok, Johannes-Peter Stasch, Berthold Hocher
BACKGROUND: The use of iodine-based contrast agents entails the risk of contrast induced nephropathy (CIN). Radiocontrast agents elicit the third most common cause of nephropathy among hospitalized patients, accounting for 11-12% of cases. CIN is connected with clinically significant consequences, including increased morbidity, prolonged hospitalization, increased risk of complications, potential need for dialysis, and increased mortality rate. The number of in-hospital examinations using iodine-based contrast media has been significantly increasing over the last decade...
2018: PloS One
https://www.readbyqxmd.com/read/29648909/diabetes-related-emergency-medical-service-activations-in-23-states-united-states-2015
#20
Stephen R Benoit, Henry S Kahn, Andrew I Geller, Daniel S Budnitz, N Clay Mann, Mengtao Dai, Edward W Gregg, Linda S Geiss
OBJECTIVE: The use of emergency medical services (EMS) for diabetes-related events is believed to be substantial but has not been quantified nationally despite the diverse acute complications associated with diabetes. We describe diabetes-related EMS activations in 2015 among people of all ages from 23 U.S. states. METHODS: We used data from 23 states that reported ≥95% of their EMS activations to the U.S. National Emergency Medical Services Information System (NEMSIS) in 2015...
April 12, 2018: Prehospital Emergency Care
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