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https://www.readbyqxmd.com/read/28925385/fine-tuning-type-i-ifn-signaling-a-new-chapter-in-the-ifn-saga
#1
Hideyuki Yanai, Tadatsugu Taniguchi
Type I interferon (IFN) signaling is critical for intracellular antimicrobial programmes, affecting both innate and adaptive immune responses. The paper recently published in Cell demonstrates a new regulatory mechanism of the type I IFN signaling pathway by histone-lysine N-methyltransferase SETD2.
September 19, 2017: Cell Research
https://www.readbyqxmd.com/read/28918903/saga-is-a-general-cofactor-for-rna-polymerase-ii-transcription
#2
Tiago Baptista, Sebastian Grünberg, Nadège Minoungou, Maria J E Koster, H T Marc Timmers, Steve Hahn, Didier Devys, László Tora
Prior studies suggested that SAGA and TFIID are alternative factors that promote RNA polymerase II transcription, with about 10% of genes in S. cerevisiae dependent on SAGA. We reassessed the role of SAGA by mapping its genome-wide location and role in global transcription in budding yeast. We find that SAGA maps to the UAS elements of most genes, overlapping with Mediator binding and irrespective of previous designations of SAGA- or TFIID-dominated genes. Disruption of SAGA through mutation or rapid subunit depletion reduces transcription from nearly all genes, measured by newly synthesized RNA...
September 11, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28918900/transcription-of-nearly-all-yeast-rna-polymerase-ii-transcribed-genes-is-dependent-on-transcription-factor-tfiid
#3
Linda Warfield, Srinivas Ramachandran, Tiago Baptista, Didier Devys, Laszlo Tora, Steven Hahn
Previous studies suggested that expression of most yeast mRNAs is dominated by either transcription factor TFIID or SAGA. We re-examined the role of TFIID by rapid depletion of S. cerevisiae TFIID subunits and measurement of changes in nascent transcription. We find that transcription of nearly all mRNAs is strongly dependent on TFIID function. Degron-dependent depletion of Taf1, Taf2, Taf7, Taf11, and Taf13 showed similar transcription decreases for genes in the Taf1-depleted, Taf1-enriched, TATA-containing, and TATA-less gene classes...
September 13, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28916771/complete-fusion-of-a-transposon-and-herpesvirus-created-the-teratorn-mobile-element-in-medaka-fish
#4
Yusuke Inoue, Tomonori Saga, Takumi Aikawa, Masahiko Kumagai, Atsuko Shimada, Yasushi Kawaguchi, Kiyoshi Naruse, Shinichi Morishita, Akihiko Koga, Hiroyuki Takeda
Mobile genetic elements (e.g., transposable elements and viruses) display significant diversity with various life cycles, but how novel elements emerge remains obscure. Here, we report a giant (180-kb long) transposon, Teratorn, originally identified in the genome of medaka, Oryzias latipes. Teratorn belongs to the piggyBac superfamily and retains the transposition activity. Remarkably, Teratorn is largely derived from a herpesvirus of the Alloherpesviridae family that could infect fish and amphibians. Genomic survey of Teratorn-like elements reveals that some of them exist as a fused form between piggyBac transposon and herpesvirus genome in teleosts, implying the generality of transposon-herpesvirus fusion...
September 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28916565/functional-specialization-of-two-paralogous-taf12-variants-by-their-selective-association-with-saga-and-tfiid-transcriptional-regulatory-complexes
#5
Ishani Sinha, Shambhu Kumar, Poonam Poonia, Sonal Sawhney, Krishnamurthy Natarajan
No abstract text is available yet for this article.
September 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28893950/the-taf10-containing-tfiid-and-saga-transcriptional-complexes-are-dispensable-for-early-somitogenesis-in-the-mouse-embryo
#6
Paul Bardot, Stéphane D Vincent, Marjorie Fournier, Alexis Hubaud, Mathilde Joint, László Tora, Olivier Pourquié
During development, tightly regulated gene expression programs control cell fate and patterning. A key regulatory step in eukaryotic transcription is the assembly of the pre-initiation complex (PIC) at promoters. The PIC assembly has mainly been studied in vitro, and little is known about its composition during development. In vitro data suggests that TFIID is the general transcription factor that nucleates PIC formation at promoters. Here we show that TAF10, a subunit of TFIID and of the transcriptional co-activator SAGA, is required for the assembly of these complexes in the mouse embryo...
September 11, 2017: Development
https://www.readbyqxmd.com/read/28887412/enzymatic-modules-of-the-saga-chromatin-modifying-complex-play-distinct-roles-in-drosophila-gene-expression-and-development
#7
Xuanying Li, Christopher W Seidel, Leanne T Szerszen, Jeffrey J Lange, Jerry L Workman, Susan M Abmayr
The Spt-Ada-Gcn5-acetyltransferase (SAGA) chromatin-modifying complex is a transcriptional coactivator that contains four different modules of subunits. The intact SAGA complex has been well characterized for its function in transcription regulation and development. However, little is known about the roles of individual modules within SAGA and whether they have any SAGA-independent functions. Here we demonstrate that the two enzymatic modules of Drosophila SAGA are differently required in oogenesis. Loss of the histone acetyltransferase (HAT) activity blocks oogenesis, while loss of the H2B deubiquitinase (DUB) activity does not...
September 8, 2017: Genes & Development
https://www.readbyqxmd.com/read/28878477/near-infrared-spectroscopy-can-reveal-increases-in-brain-activity-related-to-animal-assisted-therapy
#8
Yuka Morita, Fumio Ebara, Yoshimitsu Morita, Etsuo Horikawa
[Purpose] Previous studies have indicated that animal-assisted therapy can promote recovery of psychological, social, and physiological function in mental disorders. This study was designed as a pilot evaluation of the use of near-infrared spectroscopy to objectively identify changes in brain activity that could mediate the effect of animal-assisted therapy. [Subjects and Methods] The participants were 20 healthy students (10 males and 10 females; age 19-21 years) of the Faculty of Agriculture, Saga University...
August 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28874010/not5-dependent-co-translational-assembly-of-ada2-and-spt20-is-essential-for-functional-integrity-of-saga
#9
Sari Kassem, Zoltan Villanyi, Martine A Collart
No abstract text is available yet for this article.
July 7, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28850693/enteral-feeding-and-its-impact-on-family-mealtime-routines-for-caregivers-of-children-with-cerebral-palsy-a-mixed-method-study
#10
Marion Russell, Vanessa Jewell, Gail A Poskey, Asa Russell
BACKGROUND/AIM: Enteral feedings are part of the daily mealtime experience for many caregivers of children with cerebral palsy. The scope of occupational therapy practice incorporates multiple aspects of the enteral feeding process. Yet, the research in this area is very limited. The purpose of this study was to provide practitioners with better understanding of the impact enteral feedings of children with cerebral palsy have on family mealtime routines. METHODS: Using a complimentary mixed method approach, data were obtained through an online survey containing the Satisfaction Questionnaire with Gastrostomy Feeding (SAGA-8) and supplementary questions, and qualitative semi-structured phone interviews...
August 29, 2017: Australian Occupational Therapy Journal
https://www.readbyqxmd.com/read/28841365/taf10-and-taf10b-partially-redundant-roles-during-drosophila-melanogaster-morphogenesis
#11
Z Pahi, B N Borsos, B Vedelek, Y V Shidlovskii, S G Georgieva, I M Boros, T Pankotai
Transcription of eukaryotic genes requires the cooperative action of the RNA polymerase complex, the general transcription factors (TFIIB, TFIID, TFIIE, TFIIF and TFIIH) and chromatin modifiers. The TFIID complex contributes to transcriptional activation by several mechanisms and has a subunit with associated histone acetyltransferase (HAT) activity. The histone modifier SAGA complex has both HAT and deubiquitylase (DUB) activities. TFIID and SAGA share several TBP-associated factors (TAFs), but not their HAT subunit...
August 25, 2017: Transcription
https://www.readbyqxmd.com/read/28822993/seropositivity-and-titers-of-anti-smooth-muscle-actin-antibody-are-associated-with-relapse-of-type-1-autoimmune-hepatitis
#12
Taro Shibuki, Taiga Otsuka, Hiroshi Isoda, Norimasa Araki, Yoshihito Kubotsu, Yasunori Kawaguchi, Shunya Nakashita, Wataru Yoshioka, Seiji Kawazoe, Hiroaki Kawasoe, Yasushi Ide, Toshihiko Mizuta, Saga Study Group Of Liver Diseases Sasld
BACKGROUND It is important to avoid relapse in autoimmune hepatitis (AIH) because repeated multiple relapses have been associated with a worse prognosis. However, risk factors for relapse before initiation of treatment are not fully understood. The aim of this study was to find predictive markers for relapse of type 1 AIH. MATERIAL AND METHODS We reviewed the records of 53 patients diagnosed with type 1 AIH based on the revised scoring system proposed by the International Autoimmune Hepatitis Group (IAIHG) between 2009 and 2014 at 4 hospitals belonging to the Saga Study Group of Liver Diseases (SASLD)...
August 20, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28818287/application-of-flexible-endoscopy-based-biopsy-in-the-diagnosis-of-tumour-pathologies-in-otorhinolaryngology
#13
Carlos Saga, Manuel Olalde, Ekhiñe Larruskain, Leire Álvarez, Xabier Altuna
INTRODUCTION AND OBJECTIVES: Interventional endoscopy allows us to act on the pathology of the patient with minimal discomfort, low costs and high efficiency. We assessed the validity of flexible endoscopic biopsies in our hospital, in lesions suspected of malignancy in the rhino-pharyngo-laryngeal space. SUBJECTS AND METHODS: Retrospective study of patients with a pathology suspected of malignancy assessed between 2006-2016 in our centre. We evaluated the effectiveness, the tolerance and the number of complications...
August 14, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28775032/the-continuing-saga-of-observations-on-the-diseases-of-brunus-edwardii
#14
Caroline Wood Young
No abstract text is available yet for this article.
August 5, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28768829/the-saga-complex-together-with-transcription-factors-and-the-endocytic-protein-rvs167p-coordinate-the-reprofiling-of-gene-expression-in-response-to-changes-in-sterol-composition-in-saccharomyces-cerevisiae
#15
Gisèle Dewhurst-Maridor, Daniel Abegg, Fabrice P A David, Jacques Rougemont, Cameron C Scott, Alexander Adibekian, Howard Riezman
Changes in cellular sterol species and concentrations can have profound effects on the transcriptional profile. In yeast, mutants defective in sterol biosynthesis show a wide range of changes in transcription, including a co-induction of anaerobic genes and ergosterol biosynthesis genes, biosynthesis of basic amino acids, and several stress genes. However the mechanisms underlying these changes are unknown. We identified mutations in the SAGA complex, a co-activator of transcription, which abrogate the ability to carry out most of these sterol-dependent transcriptional changes...
August 2, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28767037/cryo-em-structure-of-the-saga-and-nua4-coactivator-subunit-tra1-at-3-7-angstrom-resolution
#16
Luis Miguel Díaz-Santín, Natasha Lukoyanova, Emir Aciyan, Alan Cm Cheung
Coactivator complexes SAGA and NuA4 stimulate transcription by post-translationally modifying chromatin. Both complexes contain the Tra1 subunit, a highly conserved 3744-residue protein from the Phosphoinositide 3-Kinase-related kinase (PIKK) family and a direct target for multiple sequence-specific activators. We present the Cryo-EM structure of Saccharomyces cerevsisae Tra1 to 3.7 Å resolution, revealing an extensive network of alpha-helical solenoids organized into a diamond ring conformation and is strikingly reminiscent of DNA-PKcs, suggesting a direct role for Tra1 in DNA repair...
August 2, 2017: ELife
https://www.readbyqxmd.com/read/28740611/development-of-potent-myostatin-inhibitory-peptides-through-hydrophobic-residue-directed-structural-modification
#17
Kentaro Takayama, Cédric Rentier, Tomo Asari, Akari Nakamura, Yusuke Saga, Takahiro Shimada, Kei Nirasawa, Eri Sasaki, Kyohei Muguruma, Akihiro Taguchi, Atsuhiko Taniguchi, Yoichi Negishi, Yoshio Hayashi
Myostatin, a negative regulator of skeletal muscle growth, is a promising target for treating muscle atrophic disorders. Recently, we discovered a minimal myostatin inhibitor 1 (WRQNTRYSRIEAIKIQILSKLRL-amide) derived from positions 21-43 of the mouse myostatin prodomain. We previously identified key residues (N-terminal Trp(21), rodent-specific Tyr(27), and all aliphatic amino acids) required for effective inhibition through structure-activity relationship (SAR) studies based on 1 and characterized a 3-fold more potent inhibitor 2 bearing a 2-naphthyloxyacetyl group at position 21...
July 13, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28726165/long-term-outcomes-of-laparoscopic-versus-open-splenectomy-for-immune-thrombocytopenia
#18
Kazuhiro Tada, Masayuki Ohta, Kunihiro Saga, Hiroomi Takayama, Teijiro Hirashita, Yuichi Endo, Hiroki Uchida, Yukio Iwashita, Masafumi Inomata
PURPOSE: Splenectomy is the standard therapy for medically refractory immune thrombocytopenia (ITP). Laparoscopic splenectomy (LS) has gained wide acceptance; however, the long-term outcomes of LS versus open splenectomy (OS) for patients with ITP remain unclear. METHODS: We analyzed, retrospectively, 32 patients who underwent splenectomy, as LS in 22 and OS in 10, for refractory ITP at our institute. Data were evaluated based on the American Society of Hematology 2011 evidence-based practice guidelines for ITP...
July 19, 2017: Surgery Today
https://www.readbyqxmd.com/read/28725170/helicobacter-pylori-infection-status-had-no-influence-on-upper-gastrointestinal-symptoms-a-cross-sectional-analysis-of-3-005-japanese-subjects-without-upper-gastrointestinal-lesions-undergoing-medical-health-checkups
#19
Tomomi Yoshioka, Eri Takeshita, Yasuhisa Sakata, Megumi Hara, Kayo Akutagawa, Natsuko Sakata, Hiroyoshi Endo, Takashi Ohyama, Keiji Matsunaga, Yuichiro Tanaka, Shinpei Shirai, Yoichiro Ito, Nanae Tsuruoka, Ryuichi Iwakiri, Motoyasu Kusano, Kazuma Fujimoto
BACKGROUND: This study aimed to evaluate the influence of Helicobacter pylori infection and its eradication on the upper gastrointestinal symptoms of relatively healthy Japanese subjects. METHODS: A total of 3,005 subjects (male/female: 1,549/1,456) undergoing medical health checkups were enrolled in the present study, at five hospitals in Saga, Japan, from January to December 2013. They had no significant findings following upper gastrointestinal endoscopy. All subjects completed a questionnaire that addressed a frequency scale for symptoms of gastroesophageal reflux disease...
2017: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/28724529/coactivators-and-general-transcription-factors-have-two-distinct-dynamic-populations-dependent-on%C3%A2-transcription
#20
Nikolaos Vosnakis, Marc Koch, Elisabeth Scheer, Pascal Kessler, Yves Mély, Pascal Didier, László Tora
SAGA and ATAC are two distinct chromatin modifying co-activator complexes with distinct enzymatic activities involved in RNA polymerase II (Pol II) transcription regulation. To investigate the mobility of co-activator complexes and general transcription factors in live-cell nuclei, we performed imaging experiments based on photobleaching. SAGA and ATAC, but also two general transcription factors (TFIID and TFIIB), were highly dynamic, exhibiting mainly transient associations with chromatin, contrary to Pol II, which formed more stable chromatin interactions...
September 15, 2017: EMBO Journal
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