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https://www.readbyqxmd.com/read/29149805/observational-cohort-study-safety-outcomes-in-children-using-proton-pump-inhibitors-or-histamine-2-receptor-antagonists
#1
Eline Houben, Saga Johansson, Péter Nagy, Fernie J A Penning-van Beest, Ernst J Kuipers, Ron M C Herings
OBJECTIVE: Acid suppression with histamine-2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs) is recommended for children with persistent gastroesophageal reflux disease symptoms. In this retrospective, observational postauthorization study, we aimed to assess and compare safety outcomes in pediatric first-time users of esomeprazole, other PPIs, or H2RAs. METHODS: Data on children (aged 0-18 years) first dispensed esomeprazole, other PPIs, or H2RAs between September 2008 and August 2011 were obtained from the Dutch PHARMO Database Network...
November 17, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29146944/structure-of-the-transcription-activator-target-tra1-within-the-chromatin-modifying-complex-saga
#2
Grigory Sharov, Karine Voltz, Alexandre Durand, Olga Kolesnikova, Gabor Papai, Alexander G Myasnikov, Annick Dejaegere, Adam Ben Shem, Patrick Schultz
The transcription co-activator complex SAGA is recruited to gene promoters by sequence-specific transcriptional activators and by chromatin modifications to promote pre-initiation complex formation. The yeast Tra1 subunit is the major target of acidic activators such as Gal4, VP16, or Gcn4 but little is known about its structural organization. The 430 kDa Tra1 subunit and its human homolog the transformation/transcription domain-associated protein TRRAP are members of the phosphatidyl 3-kinase-related kinase (PIKK) family...
November 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29146063/the-saga-continues-how-to-set-best-peep-in-intra-abdominal-hypertension
#3
EDITORIAL
Manu L N G Malbrain
No abstract text is available yet for this article.
November 8, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29141908/two-distinct-regulatory-mechanisms-of-transcriptional-initiation-in-response-to-nutrient-signaling
#4
Jannatul Ferdoush, Rwik Sen, Amala Kaja, Priyanka Barman, Sukesh R Bhaumik
SAGA (Spt-Ada-Gcn5-Acetyltransferase) and TFIID (transcription factor IID) have been previously shown to facilitate the PIC (pre-initiation complex) formation at the promoters of two distinct sets of genes. Here, we demonstrate that TFIID and SAGA differentially participate in stimulation of the PIC formation (and hence transcriptional initiation) at the promoter of PHO84, a gene for high affinity inorganic phosphate (Pi) transporter for crucial cellular functions, in response to nutrient signaling. We show that transcriptional initiation of PHO84 occurs predominantly in the TFIID-dependent manner in the absence of Pi in the growth medium...
November 15, 2017: Genetics
https://www.readbyqxmd.com/read/29133682/-against-the-tide-nothing-to-hide-the-saga-of-a-community-neurosurgeon
#5
Ramesh C Mishra
No abstract text is available yet for this article.
November 2017: Neurology India
https://www.readbyqxmd.com/read/29123104/a-prospective-randomized-trial-of-two-mucin-secretogogues-for-the-treatment-of-dry-eye-syndrome-in-office-workers
#6
Jun Shimazaki, Den Seika, Masamichi Saga, Kazumi Fukagawa, Miki Sakata, Miki Iwasaki, Takashi Okano
The purpose of the study was to compare the two mucin secretogogues, diquafosol (DQS) and rebamipide (RBM), for the treatment of dry eye syndrome (DES) in office workers. Dry eye patients using computers for >4 h/day were randomly assigned treatment with either DQS or RBM. Main outcomes measures included changes in tear film break-up time (TBUT) and subjective symptoms assessed by the Dry Eye-Related Quality of Life Score (DEQS). The subjects had scheduled examinations at 0 and 4 weeks, and the examinations at 2 and 8 weeks were optional...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29116227/saga-rooted-in-conflict-between-men-and-nature
#7
Anastasia Broadbridge
No abstract text is available yet for this article.
November 2017: Nature Plants
https://www.readbyqxmd.com/read/29111135/digital-gene-atlas-of-neonate-common-marmoset-brain
#8
Tomomi Shimogori, Ayumi Abe, Yasuhiro Go, Tsutomu Hashikawa, Noriyuki Kishi, Satomi S Kikuchi, Yoshiaki Kita, Kimie Niimi, Hirozumi Nishibe, Misako Okuno, Kanako Saga, Miyano Sakurai, Masae Sato, Tsuna Serizawa, Sachie Suzuki, Eiki Takahashi, Mami Tanaka, Shoji Tatsumoto, Mitsuhiro Toki, Mami U, Yan Wang, Karl J Windak, Haruhiko Yamagishi, Keiko Yamashita, Tomoko Yoda, Aya C Yoshida, Chihiro Yoshida, Takuro Yoshimoto, Hideyuki Okano
Interest in the common marmoset (Callithrix jacchus) as a primate model animal has grown recently, in part due to the successful demonstration of transgenic marmosets. However, there is some debate as to the suitability of marmosets, compared to more widely used animal models, such as the macaque monkey and mouse. Especially, the usage of marmoset for animal models of human cognition and mental disorders, is still yet to be fully explored. To examine the prospects of the marmoset model for neuroscience research, the Marmoset Gene Atlas (https://gene-atlas...
October 27, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/29101571/control-of-inferior-vena-cava-injury-during-laparoscopic-surgery-using-a-double-balloon-equipped-central-venous-catheter-proof-of-concept-in-a-live-porcine-model
#9
Yukio Iwashita, Hiroki Uchida, Hiroomi Takayama, Michihiro Ichimanda, Katsuya Taniguchi, Hideki Kiguchi, Tetsumi Sakaguchi, Hajime Fujishima, Kunihiro Saga, Kazuhiro Tada, Takao Hara, Kiminori Watanabe, Teijiro Hirashita, Yuichi Endo, Masayuki Ohta, Masafumi Inomata
BACKGROUND: Iatrogenic inferior vena cava (IVC) injury is a rare but potentially life-threatening complication during laparoscopic surgery. This experimental study aimed to assess the hemostatic ability of a new device, double balloon-equipped central venous (DB-CV) catheter, for IVC injury. METHODS: The DB-CV catheter comprises a triple-lumen sphincterotome combined with two dilating balloons having a diameter of 25 mm. The experimental procedures were performed in five pigs...
November 3, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29095923/pofut1-point-mutations-that-disrupt-o-fucosyltransferase-activity-destabilize-the-protein-and-abolish-notch1-signaling-during-mouse-somitogenesis
#10
Rieko Ajima, Emiko Suzuki, Yumiko Saga
The segmental pattern of the vertebrate body is established via the periodic formation of somites from the presomitic mesoderm (PSM). This periodical process is controlled by the cyclic and synchronized activation of Notch signaling in the PSM. Protein O-fucosyltransferase1 (Pofut1), which transfers O-fucose to the EGF domains of the Notch1 receptor, is indispensable for Notch signaling activation. The Drosophila homologue Ofut1 was reported to control Notch localization via two different mechanisms, working as a chaperone for Notch or as a regulator of Notch endocytosis...
2017: PloS One
https://www.readbyqxmd.com/read/29081535/-why-shall-wee-have-peace-to-bee-made-slaves-indian-surrenderers-during-and-after-king-philip-s-war
#11
Linford D Fisher
This paper is an investigation of the treatment of surrenderers in King Philip's War (1675-1676) in New England, particularly with regard to enslavement. Fear of slavery was a tangible, deep concern for most New England natives involved in the war. Threats of enslavement influenced the involvement of native individuals and groups, driving some into deeper "rebellion" and others to surrender. Each colony had differing policies for surrendering natives, but generally the thousands of surrenderers received far worse treatment than they expected, facing execution, overseas enslavement, local limited-term enslavement, and forced relocation...
2017: Ethnohistory: the Bulletin of the Ohio Valley Historic Indian Conference
https://www.readbyqxmd.com/read/29079657/torc1-and-torc2-converge-to-regulate-the-saga-co-activator-in-response-to-nutrient-availability
#12
Thomas Laboucarié, Dylane Detilleux, Ricard A Rodriguez-Mias, Céline Faux, Yves Romeo, Mirita Franz-Wachtel, Karsten Krug, Boris Maček, Judit Villén, Janni Petersen, Dominique Helmlinger
Gene expression regulation is essential for cells to adapt to changes in their environment. Co-activator complexes have well-established roles in transcriptional regulation, but less is known about how they sense and respond to signaling cues. We have previously shown that, in fission yeast, one such co-activator, the SAGA complex, controls gene expression and the switch from proliferation to differentiation in response to nutrient availability. Here, using a combination of genetic, biochemical, and proteomic approaches, we show that SAGA responds to nutrients through the differential phosphorylation of its Taf12 component, downstream of both the TORC1 and TORC2 pathways...
October 27, 2017: EMBO Reports
https://www.readbyqxmd.com/read/29066694/-clinical-evaluation-of-indoleamine-2-3-dioxygenase-in-the-serum-of-patients-with-locally-advanced-breast-cancer-during-mohs-paste-treatment
#13
Hitomi Kubota, Kenichi Sakurai, Shigeru Fujisaki, Yukiko Hara, Shuhei Suzuki, Keita Adachi, Ryouichi Tomita, Katsuhisa Enomoto, Tomohiro Hirano, Reina Saga, Makoto Makishima
Locally advanced breast cancer lesions often compromise patients' quality of life(QOL). Mohs paste is a histopathological fixative with zinc chloride as the main ingredient. It is applied when performing chemosurgery for skin tumors. In recent years, this paste has reportedly been very effective for the control of various symptoms of skin metastases in inoperable advanced cancers, such as pungent odor and hemorrhage, in the field of palliative care. We evaluated the clinical significance of indoleamine 2, 3-dioxygenase(IDO)in the serum of patients with locally advanced breast cancer during Mohs paste treatment...
October 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29066692/-clinical-evaluation-of-immunosuppressive-acidic-protein-in-the-serum-of-patients-with-inflammatory-breast-recurrence
#14
Hironori Goto, Kenichi Sakurai, Shigeru Fujisaki, Hitomi Kubota, Yukiko Hara, Shuhei Suzuki, Keita Adachi, Ryouichi Tomita, Katsuhisa Enomoto, Tomohiro Hirano, Reina Saga, Makoto Makishima
Inflammatory breast recurrence after breast conserving surgery often compromises patient quality of life(QOL)and is associated with a poor prognosis. For this type of recurrence, the immunological situation of the patient is uncertain. We evaluated the clinical significance of immunosuppressive acidic protein(IAP)in the serum of patients with inflammatory breast recurrence during treatment. We collected serum from 3 patients at three different time points: the pre-treatment phase, recurrence phase, and the post-treatment phase...
October 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29066687/-indoleamine-2-3-dioxygenase-activity-during-letrozol-therapy-for-an-elderly-breast-cancer-patient
#15
Kenichi Sakurai, Shigeru Fujisaki, Hitomi Kubota, Yukiko Hara, Shuhei Suzuki, Keita Adachi, Ryouichi Tomita, Katsuhisa Enomoto, Tomohiro Hirano, Reina Saga, Makoto Makishima
We evaluated the clinical significance of indoleamine 2,3-dioxygenase(IDO)during letrozol therapy for an elderly patient with locally advanced breast cancer. IDO activity was measured by the tryptophan(Trp)/kynurenine(Kyn)ratio. Trp and Kyn levels were measured using high performance liquid chromatography(HPLC). Serum Trp/Kyn levels of the patient before endocrine therapy were lower than those after endocrine therapy. IDO activity decreased after endocrine therapy and correlat- ed with the number of metastatic lymph node lesions during letrozol therapy...
October 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29066685/-indoleamine-2-3-dioxygenase-activity-during-fulvestrant-therapy-for-aromatase-inhibitor-resistant-metastatic-breast-cancer
#16
Kenichi Sakurai, Shigeru Fujisaki, Hitomi Kubota, Yukiko Hara, Shuhei Suzuki, Keita Adachi, Ryouichi Tomita, Katsuhisa Enomoto, Tomohiro Hirano, Reina Saga, Makoto Makishima
We evaluated the clinical significance of indoleamine 2,3-dioxygenase(IDO)for breast cancer patients between different clinical stages and patient ages. IDO activity was measured by the tryptophan(Trp)/kynurenine(Kyn)ratio. Trp and Kyn levels were measured using high performance liquid chromatography(HPLC). Serum Trp/Kyn levels in Stage IV breast cancer patients were lower than in patients at other stages. Serum Trp/Kyn levels of breast cancer patients over the age of 70 years were lower than in patients under the age of 69 years...
October 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29057759/novel-cadaver-injection-method-using-latex-and-magnetic-fluid
#17
Koichi Watanabe, Yoko Tabira, Tsuyoshi Saga, Joe Iwanaga, Wakako Matsuuchi, Daisuke Yamauchi, Hiroaki Tanaka, Shin-Ichiro Hashiguchi, Koh-Ichi Yamaki
Vascular injection into extracted tissue may be associated with leakage due to excessive local injection pressure. Historically, this complication has been impossible to resolve because the injection pressure has been the only available force with which to send the agent to the peripheral vasculature. We have developed a new vascular injection method that utilizes a material affected by magnetic force and is therefore not solely dependent upon the injection pressure. We mixed the same weights of latex and magnetic fluid and injected the solution into the arterial stump of an extracted tissue specimen...
October 20, 2017: Kurume Medical Journal
https://www.readbyqxmd.com/read/29055254/the-effect-of-visual-cues-on-performance-in-the-ultimatum-game-in-individuals-with-autism-spectrum-disorder
#18
Daisuke Ikuse, Masayuki Tani, Takashi Itahashi, Hiroki Yamada, Haruhisa Ohta, Teppei Morita, Gousuke Arai, Nobuyuki Saga, Takahiro Tokumasu, Marie Ohta, Ayaka Sato, Akira Iwanami
The Ultimatum Game (UG) allows for the assessment of altruistic behavior as well as the perception of fairness. We examined the effects of visual social cues (gaze of others), factors associated with autism, and trust on UG performance in typical adults (TAs) and individuals with autism spectrum disorder (ASD). We hypothesized that individuals with ASD would be less affected by visual social cues than TAs. We recruited 30 TAs and 30 individuals with ASD. Participants completed 30 trials of the UG, during which the visual background was altered to include either stylized eyespots, flowers, or a neutral background...
October 5, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29053020/cardiovascular-outcomes-for-patients-with-symptomatic-peripheral-artery-disease-a-cohort-study-in-the-health-improvement-network-thin-in-the-uk
#19
Lucía Cea Soriano, F Gerry R Fowkes, Saga Johansson, Alaster M Allum, Luis A García Rodriguez
Background Few data are available on risk factors and associations with outcomes in symptomatic peripheral artery disease (PAD) populations in primary care. We assessed characteristics and cardiovascular outcomes in patients with and those without symptomatic peripheral artery disease in UK primary care, and quantified risk factors for cardiovascular outcomes in patients with peripheral artery disease. Methods Among patients in The Health Improvement Network (THIN) aged 50-89 years in 2000-2010, a symptomatic peripheral artery disease cohort ( n = 28,484) and a matched comparison cohort without peripheral artery disease ( n = 113,940) were identified using Read codes...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29032513/sudden-blast-phase-in-chronic-myeloid-leukemia-developed-during-nilotinib-therapy-after-major-molecular-response-was-achieved
#20
Yosuke Okada, Ken Sato, Shinichi Kobayashi, Shigeki Nagao, Kosuke Takano, Masahiro Teramoto, Noriaki Tachi, Toshikuni Kawamura, Toshikatsu Horiuchi, Shoichiro Kato, Reina Saga, Takaaki Maekawa, Takeshi Yamamura, Junichi Watanabe, Ayako Kobayashi, Fumihiko Kimura
Sudden blast phase (SBP) is a rare event in which patients with chronic myeloid leukemia (CML) in complete cytogenetic response (CCyR) rapidly progress to the blast phase. Few patients on second-generation tyrosine kinase inhibitors (2nd TKIs) have been reported to develop SBP. Here, we report a 45-year-old man diagnosed with CML in the chronic phase in April 2008 and immediately started on imatinib therapy. He achieved CCyR 12 months after starting imatinib therapy. Imatinib was followed by treatment with the 2nd TKIs nilotinib and dasatinib from January 2011 to yield a better response...
October 14, 2017: International Journal of Hematology
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