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https://www.readbyqxmd.com/read/29772006/lessons-from-bacteriophages-part-2-a-saga-of-scientific-breakthroughs-and-prospects-for-their-use-in-human-health
#1
Kunica Asija, Carolyn M Teschke
No abstract text is available yet for this article.
May 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29771536/selective-removal-of-b800-bacteriochlorophyll-a-from-light-harvesting-complex-2-of-the-purple-photosynthetic-bacterium-phaeospirillum-molischianum
#2
Yoshitaka Saga, Keiya Hirota, Sayaka Matsui, Hitoshi Asakawa, Hiroshi Ishikita, Keisuke Saito
The selective removal of B800 bacteriochlorophyll (BChl) a from light-harvesting complex 2 (LH2) in purple photosynthetic bacteria is a clue about elucidation of the mechanism for the transfer of energy from these pigments to B850 BChl a and their roles in the LH2 protein structure. We demonstrated that the kinetics of the removal of B800 BChl a from two representative LH2 proteins derived from Phaeospirillum molischianum and Rhodoblastus acidophilus differed significantly, in contrast to the calculated binding enthalpy...
May 17, 2018: Biochemistry
https://www.readbyqxmd.com/read/29768246/the-theranos-saga-and-the-consequences
#3
EDITORIAL
Karl J Lackner, Mario Plebani
No abstract text is available yet for this article.
May 16, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29761784/ripply2-recruits-proteasome-complex-for-tbx6-degradation-to-define-segment-border-during-murine-somitogenesis
#4
Wei Zhao, Masayuki Oginuma, Rieko Ajima, Makoto Kiso, Akemi Okubo, Yumiko Saga
The metameric structure in vertebrates is based on the periodic formation of somites from the anterior end of the presomitic mesoderm (PSM). The segmentation boundary is defined by the Tbx6 expression domain, whose anterior limit is determined by Tbx6 protein destabilization via Ripply2. However, the molecular mechanism of this process is poorly understood. Here, we show that Ripply2 directly binds to Tbx6 in cultured cells without changing the stability of Tbx6, indicating an unknown mechanism for Tbx6 degradation in vivo...
May 15, 2018: ELife
https://www.readbyqxmd.com/read/29757428/micro-hotspots-of-risk-in-urban-cholera-epidemics
#5
Andrew S Azman, Francisco J Luquero, Henrik Salje, Nathan Naibei Mbaïbardoum, Ngandwe Adalbert, Mohammad Ali, Enrico Bertuzzo, Flavio Finger, Brahima Toure, Louis Albert Massing, Romain Ramazani, Bansaga Saga, Maya Allan, David Olson, Jerome Leglise, Klaudia Porten, Justin Lessler
Targeted interventions have been delivered to neighbors of cholera cases in major epidemic responses globally despite limited evidence for the impact of such targeting. Using data from urban epidemics in Chad and D.R. Congo we estimate the extent of spatiotemporal zones of increased cholera risk around cases. In both cities, we found zones of increased risk of at least 200-meters during the 5-days immediately following case presentation to a clinic. Risk was highest for those living closest to cases and diminished in time and space similarly across settings...
May 11, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29750644/the-meteoric-rise-and-dramatic-fall-of-theranos-lessons-learned-for-the-diagnostic-industry
#6
Clare Fiala, Eleftherios P Diamandis
In this piece we discuss and reflect on the conclusion of the Theranos saga in the light of its fraud conviction. Theranos (founded in 2003 by Elizabeth Holmes) was supposed to disrupt the diagnostic testing industry by developing technology which could perform dozens of tests using a tiny amount of blood from a finger-prick. As a result, Ms. Holmes rose to fame, becoming the world's youngest female self-made billionaire and was plastered across magazine covers. However, in 2014, Theranos began to fall apart following increasingly damaging revelations regarding its lack of expertise, technology, framework, extreme secrecy and inaccurate test results...
May 11, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29748367/pcsk9-from-basic-science-discoveries-to-clinical-trials
#7
REVIEW
Michael D Shapiro, Hagai Tavori, Sergio Fazio
Unknown 15 years ago, PCSK9 (proprotein convertase subtilisin/kexin type 9) is now common parlance among scientists and clinicians interested in prevention and treatment of atherosclerotic cardiovascular disease. What makes this story so special is not its recent discovery nor the fact that it uncovered previously unknown biology but rather that these important scientific insights have been translated into an effective medical therapy in record time. Indeed, the translation of this discovery to novel therapeutic serves as one of the best examples of how genetic insights can be leveraged into intelligent target drug discovery...
May 11, 2018: Circulation Research
https://www.readbyqxmd.com/read/29735637/saga-of-familial-hyperaldosteronism-yet-a-new-channel
#8
REVIEW
Livia Lenzini, Selene Prisco, Brasilina Caroccia, Gian Paolo Rossi
No abstract text is available yet for this article.
May 7, 2018: Hypertension
https://www.readbyqxmd.com/read/29732292/prevalence-of-%C3%AE-2-agonist-inhalation-for-outpatients-in-a-pediatric-emergency-center-during-enterovirus-d68-epidemic
#9
Masafumi Zaitsu, Tatsuhiro Mizoguchi, Muneaki Matsuo, Toshimitsu Takayanagi, Okito Shimada, Tsuneyoshi Baba
Background: Enterovirus D68 (EV-D68) has been reported to have caused severe bronchial asthma attacks and hospitalization epidemics in Japan in September 2015. Objective: To investigate the prevalence of β2 -agonist inhalation in a pediatric emergency center during a period of increased hospitalization for bronchial asthma, which was suggested to be associated with EV-D68. Methods: We investigated the prevalence of β2 -agonist inhalation in a pediatric emergency center in Saga city, Japan, from April 2013 to October 2015, and also clarified the trends in bronchial asthma hospitalization in the same area during that time...
April 2018: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29730796/the-saga-of-defibrillation-testing-when-less-is-more
#10
REVIEW
Marye J Gleva, Melissa Robinson, Jeanne Poole
PURPOSE OF REVIEW: In the current era of implantable cardioverter-defibrillator procedures, the decision of whether or not to perform defibrillation threshold testing at the time of implantation is now less of a clinical conundrum. In this paper, we summarize this current practice, beginning with the physiology of defibrillation, followed by a review of the salient data, and discussion of specific situations where defibrillation threshold testing remains a clinical consideration. RECENT FINDINGS: Two prospective randomized trials demonstrated no mortality difference and no overall complication rate difference between patients who underwent defibrillation testing at implant compared with patients who underwent no defibrillation testing...
May 5, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29729470/quantitative-blood-flow-assessment-by-multiparameter-analysis-of-indocyanine-green-video-angiography
#11
Masato Saito, Takehiro Saga, Hideaki Hayashi, Shohei Noro, Hajime Wada, Kyousuke Kamada
OBJECT: Measurements of quantitative blood flow are crucial during brain vascular surgery. Indocyanine green video angiography (ICG-VAG) is an accepted method of blood flow visualization. However, quantitative techniques have not been established. Thus, the aim of this study was to further develop ICG analysis in visualization of intraoperative flow change. METHODS: We conducted basic experiments and clinical investigations to establish a relationship between ICG-VAG and measured blood flow...
May 2, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29720887/rapid-progress-towards-elimination-of-lymphatic-filariasis-in-endemic-regions-of-myanmar-as-a-result-of-16-years-of-anti-filarial-activities-2001-2016
#12
Kyawt Mon Win, Jaya Prasad Tripathy, Thae Maung Maung, Tin Oo, Aung Thi, Khin Nan Lon, Zaw Lin
Background: As Myanmar progresses towards lymphatic filariasis (LF) elimination, it is important to know how well the anti-filarial activities have performed. The present study was conducted to study the implementation of the key anti-filarial activities and their impact on key indicators of LF transmission. Methods: A secondary analysis of aggregate program data on the anti-filarial activities was conducted in four endemic state/regions of Myanmar receiving at least six mass drug administration (MDA) rounds during 2001-2016...
2018: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29702713/predictors-of-bleeding-in-patients-with-symptomatic-peripheral-artery-disease-a-cohort-study-using-the-health-improvement-network-in-the-united-kingdom
#13
Lucía Cea Soriano, F Gerry R Fowkes, Alaster M Allum, Saga Johansson, Luis A García Rodriguez
The purpose of this analysis was to assess potential predictors of intra-cranial bleeding (ICB) and gastrointestinal bleeding (GIB) in patients with symptomatic peripheral artery disease (PAD) in UK primary care. Patients with symptomatic PAD diagnosed from 2000 to 2010 were identified from The Health Improvement Network (THIN; N  = 28,484). A nested case-control analysis, adjusted for potential confounders, was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for potential predictors of ICB or GIB...
April 27, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29679177/impact-of-the-number-of-removed-lymph-nodes-on-recurrence-free-survival-in-stage-i-ovarian-clear-cell-carcinoma
#14
Yuji Takei, Suzuyo Takahashi, Shizuo Machida, Akiyo Taneichi, Takahiro Yoshiba, Yoshifumi Takahashi, Chikako Yoshida, Yasushi Saga, Shigeki Matsubara, Hiroyuki Fujiwara
BACKGROUND: Although there have been several reports regarding the significance of staging lymphadenectomy for early stage ovarian clear cell carcinoma (CCC) patients, there have been few reports focusing on the number of removed lymph nodes. The aim of this study was to evaluate the impact of the number of removed lymph nodes on recurrence-free survival (RFS) in stage I ovarian CCC. METHODS: The subjects were patients with ovarian CCC who underwent surgery between January 1988 and December 2013...
April 20, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29678299/molecular-epidemiology-of-klebsiella-pneumoniae-k1-and-k2-isolates-in-japan
#15
Sohei Harada, Yoshikazu Ishii, Tomoo Saga, Kotaro Aoki, Kazuhiro Tateda
Although severe infections caused by hypervirulent Klebsiella pneumoniae isolates, such as K1 isolates belonging to sequence type (ST) 23, have been a significant problem in Asian countries, epidemiology of these isolates in Japan remains unclear. We performed a nationwide molecular epidemiological study of K. pneumoniae K1 and K2 isolates in Japan. Of the 259K. pneumoniae isolates collected, 14 and 16 isolates were identified as capsular genotypes K1 and K2, respectively. All K1 isolates were ST23 or its closely related clones and showed high genetic similarity by pulsed-field gel electrophoresis (PFGE) and the DiversiLab system (DL)...
March 20, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29666563/do-tsh-ft3-and-ft4-impact-bat-visualization-of-clinical-fdg-pet-ct-images
#16
Ryuichi Nishii, Shigeki Nagamachi, Youichi Mizutani, Tamasa Terada, Syogo Kiyohara, Hideyuki Wakamatsu, Seigo Fujita, Tatsuya Higashi, Keiichiro Yoshinaga, Tsuneo Saga, Toshinori Hirai
Objective: We retrospectively analyzed activated BAT visualization on FDG-PET/CT in patients with various conditions and TH levels to clarify the relationships between visualization of BAT on FDG-PET/CT and the effect of TH. Methods: Patients who underwent clinical FDG-PET/CT were reviewed and we categorized patients into 5 groups: (i) thyroid hormone withdrawal (THW) group; (ii) recombinant human thyrotropin (rhTSH) group; (iii) hypothyroidism group; (iv) hyperthyroidism group; and (v) BAT group...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29658200/detection-of-ureaplasma-species-by-a-semi-quantitative-pcr-test-in-urine-samples-can-it-predict-clinical-significance
#17
Merav Strauss, Raul Colodner, Dana Sagas, Azmi Adawi, Hanna Edelstein, Bibiana Chazan
BACKGROUND: Ureaplasma species (Usp) are the most prevalent genital Mycoplasma isolated from the urogenital tract of both men and women. Usp may be commensals in the genital tract but may also be contributors to a number of pathological conditions of the genital tract. Because they can also just colonize the genital tract of healthy people, their pathogenic role can be difficult to prove. OBJECTIVES: The aim of the study was to evaluate the efficacy of a quantitative polymerase chain reaction (qPCR) method for the discrimination between infection and colonization by measuring prevalence of Usp in asymptomatic versus symptomatic patients...
January 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29627177/the-evolutionary-saga-of-circumcision-from-a-religious-perspective
#18
REVIEW
Venkatachalam Raveenthiran
Circumcision is the oldest surgical operation known to mankind. It probably originated as a less radical form of genital mutilation inflicted on prisoners of war. Over time it was adopted by the Egyptian priesthood and nobility, perhaps inspired by the mythology of Osiris. In turn, circumcision became part of the Jewish and Muslim religious cultures. In contrast, ancient Greeks valued an intact prepuce, as evident from the nude figures of Renaissance art. In the 19th century, circumcision was touted as a treatment for excessive masturbation, seizures, epilepsy, and paraplegia...
March 8, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29626083/the-pseudokinase-domain-of-saccharomyces-cerevisiae-tra1-is-required-for-nuclear-localization-and-incorporation-into-the-saga-and-nua4-complexes
#19
Matthew D Berg, Julie Genereaux, Jim Karagiannis, Christopher J Brandl
Tra1 is an essential component of the SAGA/SLIK and NuA4 complexes in S. cerevisiae , recruiting these co-activator complexes to specific promoters. As a PIKK family member, Tra1 is characterized by a C-terminal phosphoinositide 3-kinase (PI3K) domain. Unlike other PIKK family members (e.g. Tor1, Tor2, Mec1, Tel1), Tra1 has no demonstrable kinase activity. We identified three conserved arginine residues in Tra1 that reside proximal or within the cleft between the N- and C-terminal subdomains of the PI3K domain...
April 6, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29619626/laparoscopic-liver-resection-in-cirrhotic-patients-with-specific-reference-to-a-difficulty-scoring-system
#20
Hiroki Uchida, Yukio Iwashita, Kazuhiro Tada, Kunihiro Saga, Hiroomi Takayama, Teijiro Hirashita, Yuichi Endo, Masayuki Ohta, Masafumi Inomata
PURPOSE: Laparoscopic liver resection is widely used for liver tumors, but its utility in patients with cirrhosis remains controversial. The aim of this study was to assess the surgical outcomes of laparoscopic liver resection in patients with liver cirrhosis with specific reference to a difficulty scoring system. METHODS: From January 2010 to March 2016, the outcomes of laparoscopic liver resection in 95 patients were retrospectively reviewed. Surgical outcomes were analyzed to identify differences between the liver cirrhosis and non-liver cirrhosis groups; these groups were further stratified to high and low difficulty scores...
April 4, 2018: Langenbeck's Archives of Surgery
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