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https://www.readbyqxmd.com/read/28209126/a-meta-analysis-reveals-complex-regulatory-properties-at-taf14-repressed-genes
#1
Josipa Nemet, Nikolina Vidan, Mary Sopta
BACKGROUND: Regulation of gene transcription in response to stress is central to a cell's ability to cope with environmental challenges. Taf14 is a YEATS domain protein in S.cerevisiae that physically associates with several transcriptionally relevant multisubunit complexes including the general transcription factors TFIID and TFIIF and the chromatin-modifying complexes SWI/SNF, INO80, RSC and NuA3. TAF14 deletion strains are sensitive to a variety of stresses suggesting that it plays a role in the transcriptional stress response...
February 16, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28208625/development-of-a-hybrid-piezo-natural-rubber-piezoelectricity-and-piezoresistivity-sensor-with-magnetic-clusters-made-by-electric-and-magnetic-field-assistance-and-filling-with-magnetic-compound-fluid
#2
Kunio Shimada, Norihiko Saga
Piezoelements used in robotics require large elasticity and extensibility to be installed in an artificial robot skin. However, the piezoelements used until recently are vulnerable to large forces because of the thin solid materials employed. To resolve this issue, we utilized a natural rubber and applied our proposed new method of aiding with magnetic and electric fields as well as filling with magnetic compound fluid (MCF) and doping. We have verified the piezoproperties of the resulting MCF rubber. The effect of the created magnetic clusters is featured in a new two types of multilayered structures of the piezoelement...
February 10, 2017: Sensors
https://www.readbyqxmd.com/read/28188921/mediator-swi-snf-and-saga-complexes-regulate-yap8-dependent-transcriptional-activation-of-acr2-in-response-to-arsenate
#3
Regina Andrade Menezes, Catarina Pimentel, Ana Rita Courelas Silva, Catarina Amaral, Jawad Merhej, Frédéric Devaux, Claudina Rodrigues-Pousada
Response to arsenic stress in Saccharomyces cerevisiae is orchestrated by the regulatory protein Yap8, which mediates transcriptional activation of ACR2 and ACR3. This study contributes to the state of art knowledge of the molecular mechanisms underlying yeast stress response to arsenate as it provides the genetic and biochemical evidences that Yap8, through cysteine residues 132, 137, and 274, is the sensor of presence of arsenate in the cytosol. Moreover, it is here reported for the first time the essential role of the Mediator complex in the transcriptional activation of ACR2 by Yap8...
February 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28184946/uptake-of-111in-labeled-fully-human-monoclonal-antibody-tsp-a18-reflects-transferrin-receptor-expression-in-normal-organs-and-tissues-of-mice
#4
Aya Sugyo, Atsushi B Tsuji, Hitomi Sudo, Fumiko Nomura, Hirokazu Satoh, Mitsuru Koizumi, Gene Kurosawa, Yoshikazu Kurosawa, Tsuneo Saga
Transferrin receptor (TfR) is an attractive molecule for targeted therapy of cancer. Various TfR-targeted therapeutic agents such as anti-TfR antibodies conjugated with anticancer agents have been developed. An antibody that recognizes both human and murine TfR is needed to predict the toxicity of antibody-based agents before clinical trials, there is no such antibody to date. In this study, a new fully human monoclonal antibody TSP-A18 that recognizes both human and murine TfR was developed and the correlation analysis of the radiolabeled antibody uptake and TfR expression in two murine strains was conducted...
March 2017: Oncology Reports
https://www.readbyqxmd.com/read/28180299/not5-dependent-co-translational-assembly-of-ada2-and-spt20-is-essential-for-functional-integrity-of-saga
#5
Sari Kassem, Zoltan Villanyi, Martine A Collart
No abstract text is available yet for this article.
February 17, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28179592/five-year-clinical-outcome-of-asymptomatic-vs-symptomatic-severe-aortic-stenosis-after-aortic-valve-replacement
#6
Shinichi Shirai, Tomohiko Taniguchi, Takeshi Morimoto, Kenji Ando, Kengo Korai, Kenji Minakata, Michiya Hanyu, Fumio Yamazaki, Tadaaki Koyama, Tatsuhiko Komiya, Norio Kanamori, Koichiro Murata, Takeshi Kitai, Yuichi Kawase, Chisato Izumi, Tsukasa Inada, Eri Minamino-Muta, Takao Kato, Moriaki Inoko, Katsuhisa Ishii, Naritatsu Saito, Kazuo Yamanaka, Noboru Nishiwaki, Hiroyuki Nakajima, Toshihiko Saga, Shogo Nakayama, Genichi Sakaguchi, Atsushi Iwakura, Kotaro Shiraga, Koji Ueyama, Keiichi Fujiwara, Senri Miwa, Junichiro Nishizawa, Mitsuru Kitano, Hitoshi Kitayama, Ryuzo Sakata, Takeshi Kimura
BACKGROUND: There is discordance regarding the effect of symptom status before aortic valve replacement (AVR) on long-term outcome after AVR in severe aortic stenosis (AS).Methods and Results:The CURRENT AS registry is a multicenter retrospective registry enrolling 3,815 consecutive patients with severe AS. Among 1,196 patients managed with the initial AVR strategy, long-term clinical outcomes were compared between the symptomatic patients (n=905), and asymptomatic patients (n=291)...
February 9, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28173750/mortality-and-morbidity-trends-after-the-first-year-in-survivors-of-acute-myocardial-infarction-a-systematic-review
#7
Saga Johansson, Annika Rosengren, Kate Young, Em Jennings
BACKGROUND: Most studies of outcomes after myocardial infarction (MI) focus on the acute phase after the index event. We assessed mortality and morbidity trends after the first year in survivors of acute MI, by conducting a systematic literature review. METHODS: Literature searches were conducted in Embase, MEDLINE, and the Cochrane Database of Systematic Reviews to identify epidemiological studies of long-term (>10 years) mortality and morbidity trends in individuals who had experienced an acute MI more than 1 year previously...
February 7, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28168841/quality-of-life-among-the-family-caregivers-of-patients-with-terminal-cancer-at-home-in-japan
#8
Eriko Ito, Etsuko Tadaka
AIM: To identify the associated factors of quality of life (QOL) among the family caregivers of patients with terminal cancer at home. METHODS: The design was an epidemiological study with self-administered questionnaires by mail. Date collection was carried out in the Tokyo Metropolitan, Tochigi, Ibaraki, Saitama, Chiba, Kanagawa, Nara, Hyogo, Kagawa, Ehime, and Saga prefectures in Japan. The participants who met the criteria for the present study were 262 family caregivers...
February 6, 2017: Japan Journal of Nursing Science: JJNS
https://www.readbyqxmd.com/read/28163270/morphometric-study-of-a-huge-elongated-styloid-process
#9
Joe Iwanaga, Koichi Watanabe, Tsuyoshi Saga, Yoko Tabira, Koh-Ichi Yamaki
An elongated styloid process (ESP) is present in 4% of the general population. It is sometimes found incidentally by panoramic radiography or computed tomography in the clinical setting. Few detailed morphometric studies of this phenomenon have been performed, however, especially regarding its histologic aspects. During anatomic dissection of a 71-year-old man who had died from cardiac failure and whose body had been donated to our department for medical student training, an ESP was found while disconnecting the stylohyoid muscle from the hyoid bone...
February 6, 2017: Kurume Medical Journal
https://www.readbyqxmd.com/read/28160502/deubiquitinating-enzyme-usp22-positively-regulates-c-myc-stability-and-tumorigenic-activity-in-mammalian-and-breast-cancer-cells
#10
Dongyeon Kim, Ahyoung Hong, Hye In Park, Woo Hyun Shin, Lang Yoo, Seo Jeong Jeon, Kwang Chul Chung
The proto-oncogene c-Myc has a pivotal function in growth control, differentiation and apoptosis and is frequently affected in human cancer, including breast cancer. Ubiquitin-specific protease 22 (USP22), a member of the USP family of deubiquitinating enzymes (DUBs), mediates deubiquitination of target proteins, including histone H2B and H2A, telomeric repeat binding factor 1, and cyclin B1. USP22 is also a component of the mammalian SAGA transcriptional co-activating complex. In this study, we explored the functional role of USP22 in modulating c-Myc stability and its physiological relevance in breast cancer progression...
February 4, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28142051/validity-of-diagnoses-procedures-and-laboratory-data-in-japanese-administrative-data
#11
Hayato Yamana, Mutsuko Moriwaki, Hiromasa Horiguchi, Mariko Kodan, Kiyohide Fushimi, Hideo Yasunaga
BACKGROUND: Validation of recorded data is a prerequisite for studies that utilize administrative databases. The present study evaluated the validity of diagnoses and procedure records in the Japanese Diagnosis Procedure Combination (DPC) data, along with laboratory test results in the newly-introduced Standardized Structured Medical Record Information Exchange (SS-MIX) data. METHODS: Between November 2015 and February 2016, we conducted chart reviews of 315 patients hospitalized between April 2014 and March 2015 in four middle-sized acute-care hospitals in Shizuoka, Kochi, Fukuoka, and Saga Prefectures and used them as reference standards...
January 27, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28139917/hybrid-catalysis-enabling-room-temperature-hydrogen-gas-release-from-n-heterocycles-and-tetrahydronaphthalenes
#12
Shota Kato, Yutaka Saga, Masahiro Kojima, Hiromu Fuse, Shigeki Matsunaga, Arisa Fukatsu, Mio Kondo, Shigeyuki Masaoka, Motomu Kanai
Hybrid catalyst systems to achieve acceptorless dehydrogenation of N-heterocycles and tetrahydronaphthalenes-model substrates for liquid organic hydrogen carriers-were developed. A binary hybrid catalysis comprising an acridinium photoredox catalyst and a Pd metal catalyst was effective for the dehydrogenation of N-heterocycles, whereas a ternary hybrid catalysis comprising an acridinium photoredox catalyst, a Pd metal catalyst, and a thiophosphoric imide organocatalyst achieved dehydrogenation of tetrahydronaphthalenes...
February 6, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28137832/chromatin-potentiates-transcription
#13
Shigeki Nagai, Ralph E Davis, Pierre Jean Mattei, Kyle Patrick Eagen, Roger D Kornberg
Chromatin isolated from the chromosomal locus of the PHO5 gene of yeast in a transcriptionally repressed state was transcribed with 12 pure proteins (80 polypeptides): RNA polymerase II, six general transcription factors, TFIIS, the Pho4 gene activator protein, and the SAGA, SWI/SNF, and Mediator complexes. Contrary to expectation, a nucleosome occluding the TATA box and transcription start sites did not impede transcription but rather, enhanced it: the level of chromatin transcription was at least sevenfold greater than that of naked DNA, and chromatin gave patterns of transcription start sites closely similar to those occurring in vivo, whereas naked DNA gave many aberrant transcripts...
January 30, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28128020/positron-emission-tomography-of-cerebral-angiogenesis-and-tspo-expression-in-a-mouse-model-of-chronic-hypoxia
#14
Iwao Kanno, Chie Seki, Hiroyuki Takuwa, Zhao-Hui Jin, Didier Boturyn, Pascal Dumy, Takako Furukawa, Tsuneo Saga, Hiroshi Ito, Kazuto Masamoto
The present study aimed to examine whether positron emission tomography (PET) could evaluate cerebral angiogenesis. Mice were housed in a hypoxic chamber with 8-9% oxygen for 4, 7, and 14 days, and the angiogenic responses were evaluated with a radiotracer, (64)Cu-cyclam-RAFT-c(-RGDfK-)4, which targeted αVβ3 integrin and was imaged with PET. The PET imaging results showed little uptake during all of the hypoxic periods. Immunofluorescence staining of the β3 integrin, CD61, revealed weak expression, while the microvessel density assessed by CD31 staining increased with the hypoxic duration...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28123717/ascorbic-acid-does-not-reduce-the-anticancer-effect-of-radiotherapy
#15
Yoichiro Hosokawa, Ryo Saga, Satoru Monzen, Shingo Terashima, Eichi Tsuruga
The present study hypothesized that the therapeutic use of ascorbic acid (AsA) in combination with radiation may reduce therapy-related side effects and increase the antitumor effects. The aim of the study was to examine the association between the scavenged activity of AsA and the biological anticancer effect of hydroxyl (OH) radicals generated by X-ray irradiation. Cell survival, DNA fragmentation of human leukemia HL60 cells and the amount of OH radicals were investigated following X-ray irradiation and AsA treatment...
January 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28123575/anti-tumor-and-anti-invasion-effects-of-a-combination-of-4-methylumbelliferone-and-ionizing-radiation-in-human-fibrosarcoma-cells
#16
Ryo Saga, Satoru Monzen, Mitsuru Chiba, Hironori Yoshino, Toshiya Nakamura, Yoichiro Hosokawa
Hyaluronan (HA) is a major component of the extracellular matrix that is synthesized in excess in cancer tissues. 4-methylumbelliferone (MU) inhibits the synthesis of HA and is closely related to the invasion and metastasis of cancer. However, the effects of MU in conjunction with cancer radiotherapy remain unknown. The present study assessed the anti-tumor and anti-invasion effects of the concomitant use of ionizing radiation (IR) and 100 µM MU on human fibrosarcoma HT1080 cells. Cell viability and cellular invasion potency assays were performed...
January 2017: Oncology Letters
https://www.readbyqxmd.com/read/28115634/roles-of-miwi-mili-and-pld6-in-small-rna-regulation-in-mouse-growing-oocytes
#17
Yuka Kabayama, Hidehiro Toh, Ami Katanaya, Takayuki Sakurai, Shinichiro Chuma, Satomi Kuramochi-Miyagawa, Yumiko Saga, Toru Nakano, Hiroyuki Sasaki
The mouse PIWI-interacting RNA (piRNA) pathway produces a class of 26-30-nucleotide (nt) small RNAs and is essential for spermatogenesis and retrotransposon repression. In oocytes, however, its regulation and function are poorly understood. In the present study, we investigated the consequences of loss of piRNA-pathway components in growing oocytes. When MILI (or PIWIL2), a PIWI family member, was depleted by gene knockout, almost all piRNAs disappeared. This severe loss of piRNA was accompanied by an increase in transcripts derived from specific retrotransposons, especially IAPs...
January 23, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28102682/identification-of-serratane-synthase-gene-from-the-fern-lycopodium-clavatum
#18
Yusuke Saga, Takeshi Araki, Hiroshi Araya, Kazuki Saito, Mami Yamazaki, Hideyuki Suzuki, Tetsuo Kushiro
Ferns are known to produce onoceroids including onoceranes and serratanes having unusual structures among triterpenes. From the fern Lycopodium clavatum, a novel onoceroid synthase gene was cloned that showed high sequence identity with a previously identified α-onocerin synthase. Functional analysis by coexpression with pre-α-onocerin synthase in yeast led to the production of tohogenol and serratenediol. The result suggested that serratanes are directly biosynthesized from pre-α-onocerin and not from α-onocerin as previously assumed...
January 19, 2017: Organic Letters
https://www.readbyqxmd.com/read/28100153/long-term-survival-after-coverage-with-prevertebral-fascia-for-abdominal-aortic-stump-closure
#19
Takehiro Inoue, Masato Imura, Toshio Kaneda, Toshihiko Saga
Abdominal aortic graft-enteric fistula is an uncommon but grave complication. Acceptable early results of its management have been reported in recent years, but aortic stump disruption remains a dreaded problem in the remote period. This report describes a case of a 71-year-old male with graft-enteric fistula following after a distant abdominal aortic aneurysm repair. The patient underwent 1-stage operation with extra-anatomic bypass preceding the complete removal of the infected aortic graft and intestinal repair...
January 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28079057/functional-mri-of-the-reserpine-induced-putative-rat-model-of-fibromyalgia-reveals-discriminatory-patterns-of-functional-augmentation-to-acute-nociceptive-stimuli
#20
Jack A Wells, Sayaka Shibata, Akihiko Fujikawa, Masayasu Takahashi, Tsuneo Saga, Ichio Aoki
Functional neuroimaging, applied to pre-clinical models of chronic pain, offers unique advantages in the drive to discover new treatments for this prevalent and oppressive condition. The high spatial and temporal resolution of fMRI affords detailed mapping of regional pharmacodynamics that underlie mechanisms of pain suppression by new analgesics. Despite evidence supporting the translational relevance of this approach, relatively few studies have investigated fMRI abnormalities in rodent models of chronic pain...
January 12, 2017: Scientific Reports
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