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https://www.readbyqxmd.com/read/28775032/the-continuing-saga-of-observations-on-the-diseases-of-brunus-edwardii
#1
Caroline Wood Young
No abstract text is available yet for this article.
August 5, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28768829/the-saga-complex-together-with-transcription-factors-and-the-endocytic-protein-rvs167p-coordinate-the-reprofiling-of-gene-expression-in-response-to-changes-in-sterol-composition-in-saccharomyces-cerevisiae
#2
Gisèle Dewhurst-Maridor, Daniel Abegg, Fabrice P A David, Jacques Rougemont, Cameron C Scott, Alexander Adibekian, Howard Riezman
Changes in cellular sterol species and concentrations can have profound effects on the transcriptional profile. In yeast, mutants defective in sterol biosynthesis show a wide range of changes in transcription, including a co-induction of anaerobic genes and ergosterol biosynthesis genes, biosynthesis of basic amino acids, and several stress genes. However the mechanisms underlying these changes are unknown. We identified mutations in the SAGA complex, a co-activator of transcription, which abrogate the ability to carry out most of these sterol-dependent transcriptional changes...
August 2, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28767037/cryo-em-structure-of-the-saga-and-nua4-coactivator-subunit-tra1-at-3-7-angstrom-resolution
#3
Luis Miguel Diaz-Santin, Natasha Lukoyanova, Emir Aciyan, Alan Cm Cheung
Coactivator complexes SAGA and NuA4 stimulate transcription by post-translationally modifying chromatin. Both complexes contain the Tra1 subunit, a highly conserved 3744-residue protein from the Phosphoinositide 3-Kinase-related kinase (PIKK) family and a direct target for multiple sequence-specific activators. We present the Cryo-EM structure of Saccharomyces cerevsisae Tra1 to 3.7 Å resolution, revealing an extensive network of alpha-helical solenoids organized into a diamond ring conformation and is strikingly reminiscent of DNA-PKcs, suggesting a direct role for Tra1 in DNA repair...
August 2, 2017: ELife
https://www.readbyqxmd.com/read/28740611/development-of-potent-myostatin-inhibitory-peptides-through-hydrophobic-residue-directed-structural-modification
#4
Kentaro Takayama, Cédric Rentier, Tomo Asari, Akari Nakamura, Yusuke Saga, Takahiro Shimada, Kei Nirasawa, Eri Sasaki, Kyohei Muguruma, Akihiro Taguchi, Atsuhiko Taniguchi, Yoichi Negishi, Yoshio Hayashi
Myostatin, a negative regulator of skeletal muscle growth, is a promising target for treating muscle atrophic disorders. Recently, we discovered a minimal myostatin inhibitor 1 (WRQNTRYSRIEAIKIQILSKLRL-amide) derived from positions 21-43 of the mouse myostatin prodomain. We previously identified key residues (N-terminal Trp(21), rodent-specific Tyr(27), and all aliphatic amino acids) required for effective inhibition through structure-activity relationship (SAR) studies based on 1 and characterized a 3-fold more potent inhibitor 2 bearing a 2-naphthyloxyacetyl group at position 21...
July 13, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28726165/long-term-outcomes-of-laparoscopic-versus-open-splenectomy-for-immune-thrombocytopenia
#5
Kazuhiro Tada, Masayuki Ohta, Kunihiro Saga, Hiroomi Takayama, Teijiro Hirashita, Yuichi Endo, Hiroki Uchida, Yukio Iwashita, Masafumi Inomata
PURPOSE: Splenectomy is the standard therapy for medically refractory immune thrombocytopenia (ITP). Laparoscopic splenectomy (LS) has gained wide acceptance; however, the long-term outcomes of LS versus open splenectomy (OS) for patients with ITP remain unclear. METHODS: We analyzed, retrospectively, 32 patients who underwent splenectomy, as LS in 22 and OS in 10, for refractory ITP at our institute. Data were evaluated based on the American Society of Hematology 2011 evidence-based practice guidelines for ITP...
July 19, 2017: Surgery Today
https://www.readbyqxmd.com/read/28725170/helicobacter-pylori-infection-status-had-no-influence-on-upper-gastrointestinal-symptoms-a-cross-sectional-analysis-of-3-005-japanese-subjects-without-upper-gastrointestinal-lesions-undergoing-medical-health-checkups
#6
Tomomi Yoshioka, Eri Takeshita, Yasuhisa Sakata, Megumi Hara, Kayo Akutagawa, Natsuko Sakata, Hiroyoshi Endo, Takashi Ohyama, Keiji Matsunaga, Yuichiro Tanaka, Shinpei Shirai, Yoichiro Ito, Nanae Tsuruoka, Ryuichi Iwakiri, Motoyasu Kusano, Kazuma Fujimoto
BACKGROUND: This study aimed to evaluate the influence of Helicobacter pylori infection and its eradication on the upper gastrointestinal symptoms of relatively healthy Japanese subjects. METHODS: A total of 3,005 subjects (male/female: 1,549/1,456) undergoing medical health checkups were enrolled in the present study, at five hospitals in Saga, Japan, from January to December 2013. They had no significant findings following upper gastrointestinal endoscopy. All subjects completed a questionnaire that addressed a frequency scale for symptoms of gastroesophageal reflux disease...
2017: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/28724529/coactivators-and-general-transcription-factors-have-two-distinct-dynamic-populations-dependent-on%C3%A2-transcription
#7
Nikolaos Vosnakis, Marc Koch, Elisabeth Scheer, Pascal Kessler, Yves Mély, Pascal Didier, László Tora
SAGA and ATAC are two distinct chromatin modifying co-activator complexes with distinct enzymatic activities involved in RNA polymerase II (Pol II) transcription regulation. To investigate the mobility of co-activator complexes and general transcription factors in live-cell nuclei, we performed imaging experiments based on photobleaching. SAGA and ATAC, but also two general transcription factors (TFIID and TFIIB), were highly dynamic, exhibiting mainly transient associations with chromatin, contrary to Pol II, which formed more stable chromatin interactions...
July 19, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28723691/high-cost-of-hospitalization-for-colonic-diverticular-bleeding-depended-on-repeated-bleeding-and-blood-transfusion-analysis-with-diagnosis-procedure-combination-data-in-japan
#8
Yoichiro Ito, Yasuhisa Sakata, Hisako Yoshida, Sayuri Nonaka, Susumu Fujii, Yuichiro Tanaka, Shimpei Shirai, Eri Takeshita, Takashi Akutagawa, Hiroharu Kawakubo, Koji Yamamoto, Nanae Tsuruoka, Ryo Shimoda, Ryuichi Iwakiri, Kazuma Fujimoto
BACKGROUND: Bleeding from a colonic diverticulum is serious in aged patients. The aim of this study was to determine the risk factors for high-cost hospitalization of colonic diverticular bleeding using the diagnosis procedure combination (DPC) data. METHODS: From January 2009 to December 2015, 78 patients with colonic diverticular bleeding were identified by DPC data in Saga Medical School Hospital. All patients underwent colonic endoscopy within 3 days. The patients were divided into 2 groups: the low-cost group (DPC cost of <500,000 yen) and the high-cost group (DPC cost of >500,000 yen)...
July 20, 2017: Digestion
https://www.readbyqxmd.com/read/28719566/midshaft-clavicle-fractures-the-saga-continues-commentary-on-articles-by-marcel-jun-sugawara-tamaoki-md-phd-et-al-treatment-of-displaced-midshaft-clavicle-fractures-figure-of-eight-harness-versus-anterior-plate-osteosynthesis-a-randomized-controlled-trial-and
#9
https://www.readbyqxmd.com/read/28710119/correction-for-saint-et-al-the-taf9-c-terminal-conserved-region-domain-is-required-for-saga-and-tfiid-promoter-occupancy-to-promote-transcriptional-activation
#10
Malika Saint, Sonal Sawhney, Ishani Sinha, Rana Pratap Singh, Rashmi Dahiya, Anushikha Thakur, Rahul Siddharthan, Krishnamurthy Natarajan
No abstract text is available yet for this article.
August 1, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28709809/editorial-commentary-tuning-in-to-sympathetic-activity-cutaneously-in-humans-a-bench-to-bedside-saga
#11
EDITORIAL
Richard L Verrier
No abstract text is available yet for this article.
June 9, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28681490/a-novel-method-for-observation-of-the-mandibular-foramen-application-to-a-better-understanding-of-dental-anatomy
#12
Joe Iwanaga, Koichi Watanabe, Tsuyoshi Saga, R Shane Tubbs, Kengo Tanaka, Shogo Kikuta, Yoko Tabira, Chistian Fisahn, Yasuhiko Kamura, Jingo Kusukawa, Koh-Ichi Yamaki
INTRODUCTION: Cone-beam computed tomography gives us much useful morphological information about the mandibular bone. Many studies of the mandible include findings from this technique. However, there have been no endoscopic studies of the mandible. MATERIALS AND METHODS: Sixteen sides of eight dry mandibles resected from cadavers (age range 38-83 years) were examined by endoscopy. The head of the endoscope was 2.0 mm in diameter. We examined the mandibular foramen, lingula, mylohyoid groove and mandibular canal...
July 6, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28676324/norursodeoxycholic-acid-in-patients-with-primary-sclerosing-cholangitis-a-new-urso-saga-in-the-horizon
#13
EDITORIAL
Olivier Chazouillères
No abstract text is available yet for this article.
July 1, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28670095/a-great-grandfather-s-account-of-the-irish-potato-famine-1845-1850
#14
EDITORIAL
John Davis Cantwell
My great-grandfather, Rodger Cantwell, and his family managed to survive the Irish famine that began in 1845. Blending what family records we have with Kelly's outstanding 2012 book about the era, the following is an historical fictional account of Rodger's saga.
July 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28661273/flying-too-close-to-the-sun-lessons-learned-from-the-judicial-expansion-of-the-objective-patient-standard-for-informed-consent-in-wisconsin
#15
Arthur R Derse
The Wisconsin Supreme Court, after adopting the doctrine of the objective (reasonable) patient standard, expanded it in bold and innovative ways over nearly four decades, until the Wisconsin legislative and executive branches drastically reversed this course. The saga has implications for other jurisdictions considering adoption or expansion of the objective patient standard doctrine.
March 2017: Journal of Law, Medicine & Ethics: a Journal of the American Society of Law, Medicine & Ethics
https://www.readbyqxmd.com/read/28657308/reversible-changes-in-the-structural-features-of-photosynthetic-light-harvesting-complex-2-by-removal-and-reconstitution-of-b800-bacteriochlorophyll-a-pigments
#16
COMPARATIVE STUDY
Yoshitaka Saga, Keiya Hirota, Hitoshi Asakawa, Kazufumi Takao, Takeshi Fukuma
Light-harvesting complex 2 (LH2) is an integral membrane protein in purple photosynthetic bacteria. This protein possesses two types of bacteriochlorophyll (BChl) a, termed B800 and B850, which exhibit lowest-energy absorption bands (Qy bands) around 800 and 850 nm. These BChl a pigments in the LH2 protein play crucial roles not only in photosynthetic functions but also in folding and maintaining its protein structure. We report herein the reversible structural changes in the LH2 protein derived from a purple photosynthetic bacterium, Rhodoblastus acidophilus, induced by the removal of B800 BChl a (denoted as B800-free LH2) and the reconstitution of exogenous BChl a...
July 11, 2017: Biochemistry
https://www.readbyqxmd.com/read/28634266/30-years-of-the-mineralocorticoid-receptor-the-brain-mineralocorticoid-receptor-a-saga-in-three-episodes
#17
REVIEW
Marian Joëls, E Ronald de Kloet
In 1968, Bruce McEwen discovered that (3)H-corticosterone administered to adrenalectomised rats is retained in neurons of hippocampus rather than those of hypothalamus. This discovery signalled the expansion of endocrinology into the science of higher brain regions. With this in mind, our contribution highlights the saga of the brain mineralocorticoid receptor (MR) in three episodes. First, the precloning era dominated by the conundrum of two types of corticosterone-binding receptors in the brain, which led to the identification of the high-affinity corticosterone receptor as the 'promiscuous' MR cloned in 1987 by Jeff Arriza and Ron Evans in addition to the classical glucocorticoid receptor (GR)...
July 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28627832/molecular-epidemiological-traits-of-group-a-rotaviruses-in-japanese-children-during-transitional-period-of-rotavirus-vaccine-implementation-2011-2014
#18
Sayaka Takanashi, Aksara Thongprachum, Shoko Okitsu, Shuichi Nishimura, Masaaki Kobayashi, Hideaki Kikuta, Atsuko Yamamoto, Kumiko Sugita, Tsuneyoshi Baba, Satoshi Hayakawa, Masashi Mizuguchi, Hiroshi Ushijima
BACKGROUND: Group A rotavirus (RVA) vaccines have been introduced in Japan since 2011. To investigate the molecular epidemiological traits of RVA during the transitional period of rotavirus vaccine implementation in Japan, this study was undertaken by following up three-decade long surveillance conducted in the same regions. METHODS: RVA were screened and genotyped by RT-PCR from diarrheal samples collected from non-hospitalized patients in six localities (Hokkaido, Tokyo, Shizuoka, Osaka, Kyoto, and Saga) during 2011 - 2014...
May 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28625726/pulmonary-administration-of-soluble-antigen-arrays-is-superior-to-antigen-in-treatment-of-experimental-autoimmune-encephalomyelitis
#19
Christopher Kuehl, Sharadvi Thati, Bradley Sullivan, Joshua Sestak, Michael Thompson, Teruna Siahaan, Cory Berkland
Antigen-specific immunotherapy (ASIT) has been used to hyposensitize patients to allergens and offers an enticing approach for attenuating autoimmune diseases. Applying ASIT to mucosal surfaces such as the lungs may engage unique immune response pathways to improve efficacy. Pulmonary delivery of soluble antigen arrays (SAgAs) was explored in mice with experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis model. SAgAs were designed to impede immune response to autoantigen epitopes and are composed of a hyaluronan backbone with peptides PLP139-151 and LABL, a disease-causing proteolipid peptide epitope and an ICAM-1 ligand, respectively...
June 15, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28604753/let-7b-and-let-7c-micrornas-promote-histone-h2b-ubiquitylation-and-inhibit-cell-migration-by-targeting-multiple-components-of-the-h2b-deubiquitylation-machinery
#20
A Spolverini, G Fuchs, D R Bublik, M Oren
Monoubiquitylation of histone H2B (H2Bub1) is catalyzed mainly by the RNF20/RNF40 complex and erased by multiple deubiquitylating enzymes (DUBs). H2Bub1 influences many aspects of chromatin function, including transcription regulation and DNA repair. Cancer cells often display reduced levels of H2Bub1, and this reduction may contribute to cancer progression. The let-7 family of microRNAs (miRNAs) comprises multiple members with reported tumor-suppressive features, whose expression is frequently downregulated in cancer...
June 12, 2017: Oncogene
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