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https://www.readbyqxmd.com/read/28079057/functional-mri-of-the-reserpine-induced-putative-rat-model-of-fibromyalgia-reveals-discriminatory-patterns-of-functional-augmentation-to-acute-nociceptive-stimuli
#1
Jack A Wells, Sayaka Shibata, Akihiko Fujikawa, Masayasu Takahashi, Tsuneo Saga, Ichio Aoki
Functional neuroimaging, applied to pre-clinical models of chronic pain, offers unique advantages in the drive to discover new treatments for this prevalent and oppressive condition. The high spatial and temporal resolution of fMRI affords detailed mapping of regional pharmacodynamics that underlie mechanisms of pain suppression by new analgesics. Despite evidence supporting the translational relevance of this approach, relatively few studies have investigated fMRI abnormalities in rodent models of chronic pain...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28069707/tfiid-or-not-tfiid-a-continuing-transcriptional-saga
#2
Slawomir Kubik, Maria Jessica Bruzzone, David Shore
No abstract text is available yet for this article.
January 9, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28032401/targeting-human-vasohibin-2-by-a-neutralizing-monoclonal-antibody-for-anti-cancer-treatment
#3
Takahiro Koyanagi, Yasuhiro Suzuki, Kazuki Komori, Yasushi Saga, Shigeki Matsubara, Hiroyuki Fujiwara, Yasufumi Sato
There are 2 members of the vasohibin (VASH) family, VASH1 and VASH2. VASH1 is expressed mainly in endothelial cells to inhibit angiogenesis, whereas VASH2 is expressed mainly in cancer cells to stimulate tumor growth. The aim of the present study was to establish neutralizing monoclonal antibody (mAb) against human VASH2 and apply it as an anti-cancer treatment. We previously raised mAbs against several synthetic peptides of hVASH1, and found that one of them exhibited neutralizing activity against hVASH1. Because of the similarity in the amino acid sequences between VASH1 and VASH2, we hypothesized that they shared the bioactive center...
December 29, 2016: Cancer Science
https://www.readbyqxmd.com/read/28010842/ultra-sensitive-hplc-photochemical-reaction-luminol-chemiluminescence-method-for-the-measurement-of-secondary-amines-after-nitrosation
#4
Hitoshi Kodamatani, Yoshimi Iwaya, Makoto Saga, Keiitsu Saito, Takahiro Fujioka, Shigeo Yamazaki, Ryo Kanzaki, Takashi Tomiyasu
A novel method for the determination of secondary amines at the nanomolar level was developed. The method is based on the nitrosation reaction of secondary amines, with the generated N-nitrosamines being measured using an HPLC separation, photochemical reaction, and chemiluminescence detection system. The efficient nitrosation of secondary amines was performed using sodium nitrite (200 mM) and acetic acid (0.8 M) at 80 °C over 60 min. Although compounds bearing OH and SH functional groups also underwent the nitrosation reaction, the sensitivity of these compounds was 1000 times lower than that of the secondary amines...
February 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27993365/building-a-bioartificial-heart-a-3-song-saga
#5
EDITORIAL
Philippe Menasché
No abstract text is available yet for this article.
November 18, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27979920/molecular-mechanisms-that-distinguish-tfiid-housekeeping-from-regulatable-saga-promoters
#6
Wim J de Jonge, Eoghan O'Duibhir, Philip Lijnzaad, Dik van Leenen, Marian Ja Groot Koerkamp, Patrick Kemmeren, Frank Cp Holstege
An important distinction is frequently made between constitutively expressed housekeeping genes versus regulated genes. Although generally characterized by different DNA elements, chromatin architecture and cofactors, it is not known to what degree promoter classes strictly follow regulatability rules and which molecular mechanisms dictate such differences. We show that SAGA-dominated/TATA-box promoters are more responsive to changes in the amount of activator, even compared to TFIID/TATA-like promoters that depend on the same activator Hsf1...
December 15, 2016: EMBO Journal
https://www.readbyqxmd.com/read/27970730/translation-and-validation-of-condition-specific-quality-of-life-pfdi-20-and-pfiq-7-questionnaires-for-women-with-pelvic-floor-dysfunction-in-the-norwegian-context
#7
C J Teig, M Bond, M S Cvancarova, M E Engh, M Kjøllesdal, T Øresland, S Saga, A Martini
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27942754/a-copper-responsive-promoter-replacement-system-to-investigate-gene-functions-in-trichoderma-reesei-a-case-study-in-characterizing-saga-genes
#8
Fanglin Zheng, Yanli Cao, Xinxing Lv, Lei Wang, Chunyan Li, Weixin Zhang, Guanjun Chen, Weifeng Liu
Trichoderma reesei represents an important workhorse for industrial production of cellulases as well as other proteins. The molecular mechanism underlying the regulation of cellulase production as well as other physiological processes in T. reesei is still insufficiently understood. We constructed a P tcu1 -based promoter substitution cassette that allowed one-step replacement of the endogenous promoter for controlling the target gene expression with copper. We then showed that copper repression of the histone acetyltransferase gene gcn5 phenocopied the gcn5 deletion strain...
December 9, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27939272/sodium-alginate-and-gum-acacia-hydrogels-of-zno-nanoparticles-show-wound-healing-effect-on-fibroblast-cells
#9
R Raguvaran, Balvinder K Manuja, Meenu Chopra, Rajesh Thakur, Taruna Anand, Anu Kalia, Anju Manuja
An ideal biomaterial for wound dressing applications should possess antibacterial and anti-inflammatory properties without any toxicity to the host cells while providing the maximum healing activity. Zinc oxide nanoparticles (ZnONPs) possess antimicrobial activity and enhance wound healing, but the questions regarding their safety arise before application to the biological systems. We synthesized ZnONPs-loaded-sodium alginate-gum acacia hydrogels (SAGA-ZnONPs) by cross linking hydroxyl groups of the polymers sodium alginate and gum acacia with the aldehyde group of gluteradehyde...
December 6, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27935223/response-to-and-toxicity-of-gemcitabine-for-recurrent-ovarian-cancer-according-to-number-of-previous-chemotherapy-regimens
#10
Yuji Takei, Yoshifumi Takahashi, Shizuo Machida, Akiyo Taneichi, Suzuyo Takahashi, Tomomi Nagashima, Hiroyuki Morisawa, Yasushi Saga, Shigeki Matsubara, Hiroyuki Fujiwara
AIM: Gemcitabine is used not only as a second-line, but also as a third-line or higher regimen for taxane/platinum-resistant recurrent ovarian cancer. The purpose of this study was to clarify the response to and toxicity of gemcitabine for recurrent ovarian cancer according to the number of previous chemotherapy regimens. METHODS: The subjects were patients with taxane/platinum-resistant recurrent ovarian cancer on gemcitabine treatment at the present hospital between June 2007 and September 2013...
December 9, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27934797/small-for-gestational-age-versus-appropriate-for-gestational-age-comparison-of-cord-blood-lipid-profile-insulin-levels-in-term-newborns-saga-act-study
#11
Limmy Loret Lobo, H Uday Kumar, Tejeswita Mishra, Tripura Sundari, Archana Singh, C Vijai Kumar, G Kondal Rao, B Jahangir, Vijay Misale, Poonam Prashant, Nirlep L Gajiwala, Ashok S Thakkar
BACKGROUND & OBJECTIVES: The genesis of atherosclerotic lesions, a major cardiovascular risk factor starts in the early stage of life. If the premature development of cardiovascular risk factors can be anticipated during childhood, cardiovascular events can be prevented effectively by taking appropriate measures. This study was carried out to assess the role of in utero malnutrition in cardiovascular disease development by comparing cord blood lipid profiles and serum insulin levels between small-for-gestational-age (SGA) and appropriate-for-gestational-age (AGA) term newborns...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27929755/fda-approves-eteplirsen-for-duchenne-muscular-dystrophy-the-next-chapter-in-the-eteplirsen-saga
#12
Annemieke Aartsma-Rus, Arthur M Krieg
No abstract text is available yet for this article.
December 8, 2016: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/27923209/recognition-of-ubiquitinated-nucleosomes
#13
REVIEW
Michael T Morgan, Cynthia Wolberger
Histone ubiquitination plays a non-degradative role in regulating transcription and the DNA damage response. A mechanistic understanding of this chromatin modification has lagged that of small histone modifications because of the technical challenges in preparing ubiquitinated nucleosomes. The recent structure of the DUB module of the SAGA coactivator complex bound to a nucleosome containing monoubiquitinated H2B has provided the first view of how specialized subunits target this enzyme to its substrate. Single particle electron microscopy of the intact SAGA coactivator suggests how the DUB module and histone acetyltransferase module engage a nucleosomal substrate...
December 3, 2016: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/27922451/direct-screening-for-chromatin-status-on-dna-barcodes-in-yeast-delineates-the-regulome-of-h3k79-methylation-by-dot1
#14
Hanneke Vlaming, Thom M Molenaar, Tibor van Welsem, Deepani W Poramba-Liyanage, Desiree E Smith, Arno Velds, Liesbeth Hoekman, Tessy Korthout, Sjoerd Hendriks, A F Maarten Altelaar, Fred van Leeuwen
Given the frequent misregulation of chromatin in cancer, it is important to understand the cellular mechanisms that regulate chromatin structure. However, systematic screening for epigenetic regulators is challenging and often relies on laborious assays or indirect reporter read-outs. Here we describe a strategy, Epi-ID, to directly assess chromatin status in thousands of mutants. In Epi-ID, chromatin status on DNA barcodes is interrogated by chromatin immunoprecipitation followed by deep sequencing, allowing for quantitative comparison of many mutants in parallel...
December 6, 2016: ELife
https://www.readbyqxmd.com/read/27921360/mortality-in-patients-who-discontinue-low-dose-acetylsalicylic-acid-therapy-after-upper-gastrointestinal-bleeding
#15
Antonio González-Pérez, María Eugenia Sáez, Saga Johansson, Péter Nagy, Luis A García Rodríguez
PURPOSE: Discontinuing low-dose acetylsalicylic acid (ASA) therapy after upper gastrointestinal bleeding (UGIB) may increase the risk of cardiovascular-related death. Our aim was to compare mortality in UK primary care patients who discontinue ASA after UGIB with that in patients who continue therapy. METHODS: ASA users at the time of UGIB and who were alive 30 days after were selected using The Health Improvement Network. Predictors of survival were assessed using adjusted Cox proportional hazards regression models...
December 6, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27919615/anatomical-study-of-the-superficial-temporal-branches-of-the-auriculotemporal-nerve-application-to-surgery-and-other-invasive-treatments-to-the-temporal-region
#16
Joe Iwanaga, Koichi Watanabe, Tsuyoshi Saga, Christian Fisahn, Rod J Oskouian, R Shane Tubbs
BACKGROUND AND AIM: The auriculotemporal nerve (ATN) is one of the branches of the mandibular division of the trigeminal nerve, which gives rise to many branches to the retromandibular and temporal regions. Of these, the superficial temporal branch can occasionally be the cause of migraine headaches and auriculotemporal neuralgia. The purpose of this study was to elucidate the anatomy of the superficial temporal branch, which has never been described in detail. METHODS: A total of 14 sides of cadaveric heads were used for this study...
November 11, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27918574/quantitative-laser-biospeckle-method-for-the-evaluation-of-the-activity-of-trypanosoma-cruzi-using-vdrl-plates-and-digital-analysis
#17
Hilda Cristina Grassi, Lisbette C García, María Lorena Lobo-Sulbarán, Ana Velásquez, Francisco A Andrades-Grassi, Humberto Cabrera, Jesús E Andrades-Grassi, Efrén D J Andrades
In this paper we report a quantitative laser Biospeckle method using VDRL plates to monitor the activity of Trypanosoma cruzi and the calibration conditions including three image processing algorithms and three programs (ImageJ and two programs designed in this work). Benznidazole was used as a test drug. Variable volume (constant density) and variable density (constant volume) were used for the quantitative evaluation of parasite activity in calibrated wells of the VDRL plate. The desiccation process within the well was monitored as a function of volume and of the activity of the Biospeckle pattern of the parasites as well as the quantitative effect of the surface parasite quantity (proportion of the object's plane)...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27913866/communicating-branches-between-lingual-and-hypoglossal-nerve-observation-using-sihler-s-staining-technique
#18
Joe Iwanaga, Koichi Watanabe, Tsuyoshi Saga, Yoko Tabira, Moriyoshi Nakamura, Christian Fisahn, R Shane Tubbs, Jingo Kusukawa, Koh-Ichi Yamaki
PURPOSE: Many dental procedures are at risk of injuring the lingual nerve. We performed this study to better elucidate the microanatomy that exists between the ipsilateral lingual and hypoglossal nerves so that iatrogenic injury can be avoided. METHODS: Adult human cadaveric tongues (ten sides) underwent Sihler's staining to identify the microanatomy between the lingual and hypoglossal nerves. RESULTS: The lingual nerve entered the middle part of the anterior two-thirds of the tongue from its lateral side and divided into two to four thick branches...
December 2, 2016: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/27901226/an-interview-with-rodrigo-f-viecilli
#19
Renato Parsekian Martins, Marcio Almeida, Armando Yukio Saga, Orlando Tanaka, Sergei Caldas Rabelo
No abstract text is available yet for this article.
September 2016: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/27899560/not5-dependent-co-translational-assembly-of-ada2-and-spt20-is-essential-for-functional-integrity-of-saga
#20
Sari Kassem, Zoltan Villanyi, Martine A Collart
Acetylation of histones regulates gene expression in eukaryotes. In the yeast Saccharomyces cerevisiae it depends mainly upon the ADA and SAGA histone acetyltransferase complexes for which Gcn5 is the catalytic subunit. Previous screens have determined that global acetylation is reduced in cells lacking subunits of the Ccr4-Not complex, a global regulator of eukaryotic gene expression. In this study we have characterized the functional connection between the Ccr4-Not complex and SAGA. We show that SAGA mRNAs encoding a core set of SAGA subunits are tethered together for co-translational assembly of the encoded proteins...
November 28, 2016: Nucleic Acids Research
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