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https://www.readbyqxmd.com/read/29333787/detection-of-ureaplasma-species-by-a-semi-quantitative-pcr-test-in-urine-samples-can-it-predict-clinical-significance
#1
Merav Strauss, Raul Colodner, Dana Sagas, Azmi Adawi, Hanna Edelstein, Bibiana Chazan
BACKGROUND: Ureaplasma species (Usp) are the most prevalent genital Mycoplasma isolated from the urogenital tract of both men and women. Usp may be commensals in the genital tract but may also be contributors to a number of pathological conditions of the genital tract. Because they can also just colonize the genital tract of healthy people, their pathogenic role can be difficult to prove. OBJECTIVES: The aim of the study was to evaluate the efficacy of a quantitative polymerase chain reaction (qPCR) method for the discrimination between infection and colonization by measuring prevalence of Usp in asymptomatic versus symptomatic patients...
January 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29333057/family-counts-deciding-when-to-murder-among-the-icelandic-vikings
#2
Markel Palmstierna, Anna Frangou, Anna Wallette, Robin Dunbar
In small scale societies, lethal attacks on another individual usually invite revenge by the victim's family. We might expect those who perpetrate such attacks to do so only when their own support network (mainly family) is larger than that of the potential victim so as to minimise the risk of retaliation. Using data from Icelandic family sagas, we show that this prediction holds whether we consider biological kin or affinal kin (in-laws): on average, killers had twice as many relatives as their victims. These findings reinforce the importance of kin as a source of implicit protection even when they are not physically present...
March 2017: Evolution and Human Behavior: Official Journal of the Human Behavior and Evolution Society
https://www.readbyqxmd.com/read/29321912/why-georeferencing-matters-introducing-a-practical-protocol-to-prepare-species-occurrence-records-for-spatial-analysis
#3
Trevor D S Bloom, Aquila Flower, Eric G DeChaine
Species Distribution Models (SDMs) are widely used to understand environmental controls on species' ranges and to forecast species range shifts in response to climatic changes. The quality of input data is crucial determinant of the model's accuracy. While museum records can be useful sources of presence data for many species, they do not always include accurate geographic coordinates. Therefore, actual locations must be verified through the process of georeferencing. We present a practical, standardized manual georeferencing method (the Spatial Analysis Georeferencing Accuracy (SAGA) protocol) to classify the spatial resolution of museum records specifically for building improved SDMs...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29316427/a-tfiid-saga-perturbation-that-targets-myb-and-suppresses-acute-myeloid-leukemia
#4
Yali Xu, Joseph P Milazzo, Tim D D Somerville, Yusuke Tarumoto, Yu-Han Huang, Elizabeth L Ostrander, John E Wilkinson, Grant A Challen, Christopher R Vakoc
Targeting of general coactivators is an emerging strategy to interfere with oncogenic transcription factors (TFs). However, coactivator perturbations often lead to pleiotropic effects by influencing numerous TFs. Here we identify TAF12, a subunit of TFIID and SAGA coactivator complexes, as a selective requirement for acute myeloid leukemia (AML) progression. We trace this dependency to a direct interaction between the TAF12/TAF4 histone-fold heterodimer and the transactivation domain of MYB, a TF with established roles in leukemogenesis...
January 8, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29311082/deletion-of-ada2-increases-antifungal-drug-susceptibility-and-virulence-in-candida-glabrata
#5
Shang-Jie Yu, Ya-Lin Chang, Ying-Lien Chen
Candida glabrata, the second most frequent cause of candidiasis after Candida albicans, is an emerging human fungal pathogen that is intrinsically drug tolerant. Currently, studies of C. glabrata genes involved in drug tolerance are limited. Ada2, a component serving as a transcription adaptor of the Spt-Ada-Gcn5 acetyltransferase (SAGA) complex, is required for antifungal drug tolerance and virulence in C. albicans However, its roles in C. glabrata remain elusive. In this study, we found that ada2 mutants demonstrated severe growth defects at 40°C but only mild defects at 37°C or 25°C...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29304079/particle-number-analysis-of-lipoprotein-subclasses-by-gel-permeation-hplc-in-patients-with-cholesteryl-ester-transfer-protein-deficiency
#6
Takeshi Okada, Tohru Ohama, Mitsuyo Okazaki, Kotaro Kanno, Hibiki Matsuda, Masami Sairyo, Yinghong Zhu, Ayami Saga, Takuya Kobayashi, Daisaku Masuda, Masahiro Koseki, Makoto Nishida, Yasushi Sakata, Shizuya Yamashita
OBJECTIVE: We previously reported that patients with cholesteryl ester transfer protein (CETP) deficiency (CETP-D) have a higher prevalence of atherosclerotic cardiovascular disease, in spite of increased HDL-C levels. However, characterization of HDL in CETP-D has not been well described. Therefore, we examined HDL particle number (PN) rather than HDL-C level. APPROACH AND RESULTS: Nine patients with CETP-D and 9 normolipidemic subjects were enrolled. We performed gel permeation high-performance liquid chromatography (GP-HPLC) analysis, determined the cholesterol and triglyceride composition of all lipoprotein subclasses, and calculated the PN of each subclass, which consisted of 3 VLDL (large, medium, and small), 4 LDL (large, medium, small, and very small), and 5 HDL (very large, large, medium, small, and very small) subclasses...
2018: PloS One
https://www.readbyqxmd.com/read/29284213/pathologic-and-molecular-characterization-of-streptococcus-dysgalactiae-subspecies-equisimilis-infection-in-neonatal-piglets
#7
Sang-Ik Oh, Jong Wan Kim, Ji-Youl Jung, Myeongju Chae, Yu-Ran Lee, Jong Ho Kim, ByungJae So, Ha-Young Kim
Streptococcus dysgalactiae subspecies equisimilis (SDSE) is an emerging pathogen in animals and humans. Here, we describe two clinical swine cases of SDSE infection presenting with lameness, neurological signs, or sudden death. Pathological examination indicated suppurative arthritis, encephalitis, and multifocal abscesses in the kidney and heart. β-hemolytic colonies from the joint samples of each case were identified as SDSE. The isolates showed low minimum inhibitory concentration values for β-lactams and presented the same virulence gene profile (slo-/sagA+/pSTKP8+)...
December 28, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/29259748/discovery-of-a-slow-tight-binding-lpa1-antagonist-ono-0300302-for-the-treatment-of-benign-prostatic-hyperplasia
#8
Masahiko Terakado, Hidehiro Suzuki, Kazuya Hashimura, Motoyuki Tanaka, Hideyuki Ueda, Keisuke Hirai, Masaki Asada, Masahiro Ikura, Naoki Matsunaga, Hiroshi Saga, Koji Shinozaki, Naoko Karakawa, Yuka Takada, Masashi Minami, Hiromu Egashira, Yoshihiro Sugiura, Masanori Yamada, Shinji Nakade, Yoshikazu Takaoka
Scaffold hopping from the amide group of lead compound ONO-7300243 (1) to a secondary alcohol successfully gave a novel chemotype lysophosphatidic acid receptor 1 (LPA1) antagonist 4. Wash-out experiments using rat isolated urethra showed that compound 4 possesses a tight binding feature to the LPA1 receptor. Further modification of two phenyl groups of 1 to pyrrole and an indane moiety afforded an optimized compound ONO-0300302 (19). Despite its high i.v. clearance, 19 inhibited significantly an LPA-induced increase of intraurethral pressure (IUP) in rat (3 mg/kg, p...
December 14, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29236810/the-saga-of-psychoanalysis-in-eastern-europe-repression-and-rebirth-in-hungary-and-in-former-czechoslovakia-and-yugoslavia
#9
Judit Mészáros
The paper shortly presents the early roles of Budapest, Prague, and Belgrade in the development of psychoanalytic movement in Central-Europe before the Second World War. Mapping this historical heritage, it suggests how psychoanalysts of former Soviet Bloc countries could restore their own psychoanalytic communities. The study investigates the consequences of these dictatorial and authoritarian regimes for psychoanalysis and for psychoanalysts focusing on similarities and differences in Hungary, in former Czechoslovakia, and Yugoslavia...
November 2017: História, Ciências, Saúde—Manguinhos
https://www.readbyqxmd.com/read/29232376/che1-aatf-interacts-with-subunits-of-the-histone-acetyltransferase-core-module-of-saga-complexes
#10
Gizem Caliskan, Ikbal C Baris, Ferhan Ayaydin, Melanie J Dobson, Muge Senarisoy, Imre M Boros, Zeki Topcu, Sevil Zencir
General Control Non-derepressible 5 (GCN5) and Alteration/Deficiency in Activation 2 and 3 proteins (ADA2 and ADA3, respectively) are subunits of the Histone AcetylTransferase (HAT) module of SAGA- and ATAC-type co-activators. We previously reported four new interacting partners of human ADA3 identified by screening a human fetal brain cDNA library using yeast two hybrid technology. One of these partners was Apoptosis-Antagonizing Transcription Factor (AATF), also known as Che-1, an RNA polymerase II-binding protein with a number of roles in different cellular processes including regulation of transcription, cell proliferation, cell cycle control, DNA damage responses and apoptosis...
2017: PloS One
https://www.readbyqxmd.com/read/29226042/direct-insertion-of-the-papillary-muscle-into-the-anterior-mitral-leaflet-cadaveric-findings
#11
Sarvenaz Sheikh, Joe Iwanaga, Jocelyn R Gonzales, Tsuyoshi Saga, Marios Loukas, Rod J Oskouian, R Shane Tubbs
Direct insertion of the anterior papillary muscle (DPM) into the mitral valve is uncommon. During the routine dissection of an adult female, a DPM into the mitral valve with abnormal chordae tendinae was observed. This abnormal papillary muscle was measured as 28.0 mm in length from myocardial to insertion, 14.8 mm in width, and 7.0 mm in depth. The embryology, symptoms, associated cardiac diseases, and surgical precautions of this congenital malformation in the heart are reviewed.
October 5, 2017: Curēus
https://www.readbyqxmd.com/read/29221235/triaging-patients-with-left-main-disease-after-the-excel-and-noble-trials-the-everlasting-saga-of-coronary-artery-bypass-grafting-and-percutaneous-coronary-intervention
#12
EDITORIAL
https://www.readbyqxmd.com/read/29220825/effects-of-nutritional-education-on-weight-change-and-metabolic-abnormalities-among-patients-with-schizophrenia-in-japan-a-randomized-controlled-trial
#13
Norio Sugawara, Toyoaki Sagae, Norio Yasui-Furukori, Manabu Yamazaki, Kazutaka Shimoda, Takao Mori, Takuro Sugai, Hiroshi Matsuda, Yutaro Suzuki, Yuji Ozeki, Kurefu Okamoto, Toshiyuki Someya
OBJECTIVE: Patients with schizophrenia have a higher prevalence of metabolic syndrome (MetS) than the general population. Minimizing weight gain and metabolic abnormalities in a population with an already high prevalence of obesity is of clinical and social importance. This randomized controlled trial investigated the effect of monthly nutritional education on weight change and metabolic abnormalities among patients with schizophrenia in Japan. METHODS: From July 2014 to December 2014, we recruited 265 obese patients who had a DSM-IV diagnosis of schizophrenia or schizoaffective disorder...
December 4, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29204055/combined-treatment-of-pancreatic-cancer-xenograft-with-90y-itga6b4-mediated-radioimmunotherapy-and-pi3k-mtor-inhibitor
#14
Winn Aung, Atsushi B Tsuji, Hitomi Sudo, Aya Sugyo, Yoshinori Ukai, Katsushi Kouda, Yoshikazu Kurosawa, Takako Furukawa, Tsuneo Saga, Tatsuya Higashi
AIM: To investigate the therapeutic effect of combined integrin α6β4-targeted radioimmunotherapy (RIT) and PI3K/mTOR inhibitor BEZ235 in a pancreatic cancer model. METHODS: Phosphorylation of Akt, mTOR, the downstream effectors eukaryotic initiation factor 4E binding protein 1 (4EBP1) and S6 ribosomal protein (S6) were evaluated in BxPC-3 human pancreatic cancer cells treated with Yttrium-90 (90Y) labeled anti-integrin α6β4 antibody (ITGA6B4) and BEZ235 by western blotting...
November 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29187668/exploring-risk-factors-of-patient-falls-a-retrospective-hospital-record-study-in-japan
#15
Mami Ishikuro, Sergio Ramón Gutiérrez Ubeda, Taku Obara, Toshihide Saga, Naofumi Tanaka, Chiyo Oikawa, Keisei Fujimori
Patient falls are common adverse medical events in hospitals. The objectives of this study were to clarify the factors of patient falls at hospitalization or transfer to another ward, which could be assumed that patients experience new environment. Patients who were hospitalized or transferred to another ward at a hospital in Japan, between January 14 and February 14, 2014 were included. We used a risk assessment sheet and applied stepwise regression analysis to identify factors of patient falls. We also investigated changes in patient conditions on the risk assessment sheet by the chi-square test...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29186845/banning-asbestos-in-new-zealand-1936-2016-an-80-year-long-saga
#16
William Ivan Glass, Rob Armstrong, Grace Chen
The banning by the New Zealand Government of the import and export of asbestos-containing products resulted from the interplay of a number of factors. At a personal level, there were the actions of the asbestos sufferers, their families and support groups. At the political level, there were the activities of progressive trade union groups representing the hazardous trades, such as labourers, construction workers and demolition workers, and at a Government level, there was a positive response to these public health pressures...
November 25, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29179478/64cu-atsm-internal-radiotherapy-to-treat-tumors-with-bevacizumab-induced-vascular-decrease-and-hypoxia-in-human-colon-carcinoma-xenografts
#17
Yukie Yoshii, Mitsuyoshi Yoshimoto, Hiroki Matsumoto, Takako Furukawa, Ming-Rong Zhang, Masayuki Inubushi, Atsushi B Tsuji, Yasuhisa Fujibayashi, Tatsuya Higashi, Tsuneo Saga
Bevacizumab, an anti-vascular endothelial growth factor (VEGF) antibody, is an antiangiogenic agent clinically used for various cancers. However, repeated use of this agent leads to tumor-decreased vascularity and hypoxia with activation of an HIF-1 signaling pathway, which results in drug delivery deficiency and induction of malignant behaviors in tumors. Here, we developed a novel strategy to treat tumors with bevacizumab-induced vascular decrease and hypoxia using 64Cu-diacetyl-bis (N4-methylthiosemicarbazone) (64Cu-ATSM), a potential theranostic agent, which possesses high tissue permeability and can target over-reduced conditions under hypoxia in tumors, with a human colon carcinoma HT-29 tumor-bearing mouse model...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29176831/saga-mediates-transcription-from-the-tata-like-element-independently-of-taf1p-tfiid-but-dependent-on-core-promoter-structures-in-saccharomyces-cerevisiae
#18
Kiyoshi Watanabe, Tetsuro Kokubo
In Saccharomyces cerevisiae, core promoters of class II genes contain a TATA element, either a TATA box (TATA[A/T]A[A/T][A/G]) or TATA-like element (1 or 2 bp mismatched version of the TATA box). The TATA element directs the assembly of the preinitiation complex (PIC) to ensure accurate transcriptional initiation. It has been proposed the PIC is assembled by two distinct pathways in which TBP is delivered by TFIID or SAGA, leading to the widely accepted model that these complexes mediate transcription mainly from TATA-like element- or TATA box-containing promoters, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/29176731/itims-episode-1-of-the-inhibitory-saga
#19
Eric Vivier
No abstract text is available yet for this article.
November 27, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/29149805/observational-cohort-study-safety-outcomes-in-children-using-proton-pump-inhibitors-or-histamine-2-receptor-antagonists
#20
Eline Houben, Saga Johansson, Péter Nagy, Fernie J A Penning-van Beest, Ernst J Kuipers, Ron M C Herings
OBJECTIVE: Acid suppression with histamine-2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs) is recommended for children with persistent gastroesophageal reflux disease symptoms. In this retrospective, observational postauthorization study, we aimed to assess and compare safety outcomes in pediatric first-time users of esomeprazole, other PPIs or H2RAs. METHODS: Data on children (aged 0-18 years) first dispensed esomeprazole, other PPIs or H2RAs between September 2008 and August 2011 was obtained from the Dutch PHARMO Database Network...
November 24, 2017: Current Medical Research and Opinion
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