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https://www.readbyqxmd.com/read/29351565/sumo-targeting-of-a-stress-tolerant-ulp1-sumo-protease
#1
Jennifer Peek, Catherine Harvey, Dreux Gray, Danny Rosenberg, Likhitha Kolla, Reuben Levy-Myers, Rui Yin, Jonathan L McMurry, Oliver Kerscher
SUMO proteases of the SENP/Ulp family are master regulators of both sumoylation and desumoylation and regulate SUMO homeostasis in eukaryotic cells. SUMO conjugates rapidly increase in response to cellular stress, including nutrient starvation, hypoxia, osmotic stress, DNA damage, heat shock, and other proteotoxic stressors. Nevertheless, little is known about the regulation and targeting of SUMO proteases during stress. To this end we have undertaken a detailed comparison of the SUMO-binding activity of the budding yeast protein Ulp1 (ScUlp1) and its ortholog in the thermotolerant yeast Kluyveromyces marxianus, KmUlp1...
2018: PloS One
https://www.readbyqxmd.com/read/29351555/omega-3-fatty-acid-desaturase-gene-family-from-two-%C3%AF-3-sources-salvia-hispanica-and-perilla-frutescens-cloning-characterization-and-expression
#2
Yufei Xue, Baojun Chen, Aung Naing Win, Chun Fu, Jianping Lian, Xue Liu, Rui Wang, Xingcui Zhang, Yourong Chai
Omega-3 fatty acid desaturase (ω-3 FAD, D15D) is a key enzyme for α-linolenic acid (ALA) biosynthesis. Both chia (Salvia hispanica) and perilla (Perilla frutescens) contain high levels of ALA in seeds. In this study, the ω-3 FAD gene family was systematically and comparatively cloned from chia and perilla. Perilla FAD3, FAD7, FAD8 and chia FAD7 are encoded by single-copy (but heterozygous) genes, while chia FAD3 is encoded by 2 distinct genes. Only 1 chia FAD8 sequence was isolated. In these genes, there are 1 to 6 transcription start sites, 1 to 8 poly(A) tailing sites, and 7 introns...
2018: PloS One
https://www.readbyqxmd.com/read/29350514/hospitalized-patients-and-family-members-preferences-for-real-time-transparent-access-to-their-hospital-records
#3
Michael J Waxman, Kurt Lozier, Lana Vasiljevic, Kira Novakofski, James Desemone, John O'Kane, Elizabeth M Dufort, David Wood, Ashar Ata, Louis Filhour, Richard J Blinkhorn
OBJECTIVES: To better understand patient satisfaction and perceived engagement with traditional hospital-based communication and to elicit patient preferences for health information technologies that would lead to improved satisfaction and engagement. STUDY DESIGN: We performed a mixed-methods study involving qualitative interviews followed by a survey of hospitalized patients and their family members at a single large academic medical center. METHODS: We conducted semi-structured interviews with 41 patients and surveyed 267 patients or family members to elicit their perspectives on satisfaction with traditional hospital communication methods, information needed to more fully engage in the patients' medical care, and potential solutions for improved hospital-based communication...
January 1, 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29350485/purification-of-glutathione-s-transferase-enzyme-from-quail-liver-tissue-and-inhibition-effects-of-3ar-4s-7r-7as-2-4-e-3-aryl-acryloyl-phenyl-3a-4-7-7a-tetrahydro-1h-4-7-methanoisoindole-1-3-2h-dione-derivatives-on-the-enzyme-activity
#4
Yusuf Temel, Umit M Koçyigit, M Şerif Taysı, Faik Gökalp, Meliha Burcu Gürdere, Yakup Budak, Mustafa Ceylan, İlhami Gülçin, Mehmet Çiftci
The use of quail meat and eggs has made this animal important in recent years, with its low cost and high yields. Glutathione S-transferases (GST, E.C.2.5.1.18) are an important enzyme family, which play a critical role in detoxification system. In our study, GST was purified from quail liver tissue with 47.88-fold purification and 12.33% recovery by glutathione agarose affinity chromatography. The purity of enzyme was checked by SDS-PAGE method and showed a single band. In addition, inhibition effects of (3aR,4S,7R,7aS)-2-(4-((E)-3-(aryl)acryloyl)phenyl)-3a,4,7,7a-tetrahydro-1H-4,7methanoisoindole-1,3(2H)-dion derivatives (1a-g) were investigated on the enzyme activity...
January 19, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29350282/neutrophil-chemotaxis
#5
REVIEW
Björn Petri, Maria-Jesús Sanz
Neutrophils are the primary cells recruited to inflamed sites during an innate immune response to tissue damage and/or infection. They are finely sensitive to inciting stimuli to reach in great numbers and within minutes areas of inflammation and tissue insult. For this effective response, they can detect extracellular chemical gradients and move towards higher concentrations, the so-called chemotaxis process or guided cell migration. This directed neutrophil recruitment is orchestrated by chemoattractants, a chemically diverse group of molecular guidance cues (e...
January 19, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29349728/correction-to-mental-health-needs-and-psychoactive-drug-use-in-a-user-population-of-the-family-health-strategy-fhs-in-ribeir%C3%A3-o-preto-s%C3%A3-o-paulo-brazil
#6
Margarita Antonia Villar Luis, Sara Pinto Barbosa, Jacqueline de Souza, Kelly Graziani Giacchero Vedana, Ana Carolina Guidorizzi Zanetti, João Mazzoncini de Azevedo Marques
The original version of this article unfortunately published without acknowledgement. The funding information and grant number is given below: Funding Research supported by Research in Public for the National Health Care System (PP-SUS), Grant number 12/51732-9.
January 18, 2018: Community Mental Health Journal
https://www.readbyqxmd.com/read/29349559/a-mutant-hcn4-channel-in-a-family-with-bradycardia-left-bundle-branch-block-and-left-ventricular-noncompaction
#7
Ryosuke Yokoyama, Koshi Kinoshita, Yukiko Hata, Masayoshi Abe, Kenta Matsuoka, Keiichi Hirono, Masanobu Kano, Makoto Nakazawa, Fukiko Ichida, Naoki Nishida, Toshihide Tabata
We found that a female infant presenting with left bundle branch block and left ventricular noncompaction carries uninvestigated gene mutations HCN4(G811E), SCN5A(L1988R), DMD(S2384Y), and EMD(R203H). Here, we explored the possible pathogenicity of HCN4(G811E), which results in a G811E substitution in hyperpolarization-activated cyclic nucleotide-gated channel 4, the main subunit of the cardiac pacemaker channel. Voltage-clamp measurements in a heterologous expression system of HEK293T cells showed that HCN4(G811E) slightly reduced whole-cell HCN4 channel conductance, whereas it did not affect the gating kinetics, unitary conductance, or cAMP-dependent modulation of voltage-dependence...
January 18, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29348884/alpha-1-antitrypsin-functions-as-a-protective-factor-in-preeclampsia-through-activating-smad2-and-inhibitor-of-dna-binding-4
#8
Yaling Feng, Nan Wang, Jianjuan Xu, Jinfang Zou, Xi Liang, Huan Liu, Ying Chen
Pre-eclampsia (PE) is one of the most common reason for high morbidity and mortality of maternal and prenatal infants. Production from oxidative stress results in maternal ROS system and anti-oxidation defense system imbalance to promote tissue ischemia and hypoxia, and ultimately impairs the maternal organs and placenta. Our previous study showed that exogenous Alpha-1-antitrypsin (AAT) and overexpression of AAT in umbilical vein cell (HUVEC) hypoxia-reoxygenation model could increase the activity of antioxidant enzymes, and played a protective role in preeclampsia animal model...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29348634/a-biosensor-based-framework-to-measure-latent-proteostasis-capacity
#9
Rebecca J Wood, Angelique R Ormsby, Mona Radwan, Dezerae Cox, Abhishek Sharma, Tobias Vöpel, Simon Ebbinghaus, Mikael Oliveberg, Gavin E Reid, Alex Dickson, Danny M Hatters
The pool of quality control proteins (QC) that maintains protein-folding homeostasis (proteostasis) is dynamic but can become depleted in human disease. A challenge has been in quantitatively defining the depth of the QC pool. With a new biosensor, flow cytometry-based methods and mathematical modeling we measure the QC capacity to act as holdases and suppress biosensor aggregation. The biosensor system comprises a series of barnase kernels with differing folding stability that engage primarily with HSP70 and HSP90 family proteins...
January 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29348260/the-canadian-preterm-birth-network-a-study-protocol-for-improving-outcomes-for-preterm-infants-and-their-families
#10
Prakesh S Shah, Sarah D McDonald, Jon Barrett, Anne Synnes, Kate Robson, Jonathan Foster, Jean-Charles Pasquier, K S Joseph, Bruno Piedboeuf, Thierry Lacaze-Masmonteil, Karel O'Brien, Sandesh Shivananda, Nils Chaillet, Petros Pechlivanoglou
BACKGROUND: Preterm birth (birth before 37 wk of gestation) occurs in about 8% of pregnancies in Canada and is associated with high mortality and morbidity rates that substantially affect infants, their families and the health care system. Our overall goal is to create a transdisciplinary platform, the Canadian Preterm Birth Network (CPTBN), where investigators, stakeholders and families will work together to improve childhood outcomes of preterm neonates. METHODS: Our national cohort will include 24 maternal-fetal/obstetrical units, 31 neonatal intensive care units and 26 neonatal follow-up programs across Canada with planned linkages to provincial health information systems...
January 18, 2018: CMAJ Open
https://www.readbyqxmd.com/read/29348124/organic-anion-transporting-polypeptide-1a4-is-responsible-for-the-hepatic-uptake-of-cardiac-glycosides-in-mice
#11
Junichi Takano, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama
Among organic anion transporting polypeptide (Oatp) family transporters expressed in the rodent liver, such as Oatp1a1, Oatp1a4, Oatp1b2, and Oatp2b1, Oatp1a4 has a unique character to recognize neutral cardiac glycosides as substrate in addition to organic anions. The relative contribution of Oatp1a4 to the substrate uptake into hepatocytes has not been clarified. In this study, we investigated the importance of Oatp1a4 in the hepatic uptake of its substrate drugs using Slco1a4-/- mice. The hepatic mRNA expression of Slco1a4 was decreased significantly in Slco1a4-/- mice, whereas no differences were seen in other hepatic transporters between wild-type and Slco1a4-/- mice...
January 18, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29347840/barriers-and-enablers-to-the-implementation-of-school-wellness-policies-an-economic-perspective
#12
Brittany R Schuler, Brit I Saksvig, Joy Nduka, Susannah Beckerman, Lea Jaspers, Maureen M Black, Erin R Hager
BACKGROUND: Local wellness policies (LWPs) are mandated among school systems to enhance nutrition/physical activity opportunities in schools. Prior research notes disparities in LWP implementation. This study uses mixed methods to examine barriers/enablers to LWP implementation, comparing responses by student body income. METHOD: Schools ( n = 744, 24 systems) completed an LWP implementation barriers/enablers survey. Semistructured interviews ( n = 20 random subsample) described barriers/enablers...
January 1, 2018: Health Promotion Practice
https://www.readbyqxmd.com/read/29347522/semiclassical-catastrophe-theory-of-simple-bifurcations
#13
A G Magner, K Arita
The Fedoriuk-Maslov catastrophe theory of caustics and turning points is extended to solve the bifurcation problems by the improved stationary phase method (ISPM). The trace formulas for the radial power-law (RPL) potentials are presented by the ISPM based on the second- and third-order expansion of the classical action near the stationary point. A considerable enhancement of contributions of the two orbits (pair consisting of the parent and newborn orbits) at their bifurcation is shown. The ISPM trace formula is proposed for a simple bifurcation scenario of Hamiltonian systems with continuous symmetries, where the contributions of the bifurcating parent orbits vanish upon approaching the bifurcation point due to the reduction of the end-point manifold...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347517/embedding-the-dynamics-of-a-single-delay-system-into-a-feed-forward-ring
#14
Vladimir Klinshov, Dmitry Shchapin, Serhiy Yanchuk, Matthias Wolfrum, Otti D'Huys, Vladimir Nekorkin
We investigate the relation between the dynamics of a single oscillator with delayed self-feedback and a feed-forward ring of such oscillators, where each unit is coupled to its next neighbor in the same way as in the self-feedback case. We show that periodic solutions of the delayed oscillator give rise to families of rotating waves with different wave numbers in the corresponding ring. In particular, if for the single oscillator the periodic solution is resonant to the delay, it can be embedded into a ring with instantaneous couplings...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347104/visibility-graphs-of-random-scalar-fields-and-spatial-data
#15
Lucas Lacasa, Jacopo Iacovacci
We extend the family of visibility algorithms to map scalar fields of arbitrary dimension into graphs, enabling the analysis of spatially extended data structures as networks. We introduce several possible extensions and provide analytical results on the topological properties of the graphs associated to different types of real-valued matrices, which can be understood as the high and low disorder limits of real-valued scalar fields. In particular, we find a closed expression for the degree distribution of these graphs associated to uncorrelated random fields of generic dimension...
July 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346716/neuropeptide-af-induces-piecemeal-degranulation-in-murine-mucosal-mast-cells-a-new-mediator-in-neuro-immune-communication-in-the-intestinal-lamina-propria
#16
Nada Abdellah, Samuel Van Remoortel, Omnia Mohey-Elsaeed, Mohamed-Nabil Mostafa, Yasser A Ahmed, Jean-Pierre Timmermans, Roeland Buckinx
Neuropeptides AF (NPAF), FF (NPFF) and SF (NPSF) are RFamide neuropeptides known to be widely expressed in the mammalian central nervous system, where they fulfill a wide range of functions with pain modulation being the most prominent one. Recent evidence indicates that RFamides act as mediators in mast cell-sensory nerve communications related to allergic disease. Previous work by our group has shown that the expression levels of some members of the Mas-related gene receptor (Mrgpr) family in both enteric neurons and mucosal mast cells change during intestinal inflammation...
January 18, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29346551/brazil-s-family-health-strategy-factors-associated-with-programme-uptake-and-coverage-expansion-over-15-years-1998-2012
#17
Monica Viegas Andrade, Augusto Quaresma Coelho, Mauro Xavier Neto, Lucas Resende de Carvalho, Rifat Atun, Marcia C Castro
Universal Health Coverage (UHC) is one of the United Nations Sustainable Development Goals (SDGs). Achieving UHC will require strong health systems to promote and deliver equitable and integrated healthcare services through primary healthcare (PHC). In Brazil, the Family Health Strategy (FHS) delivers PHC through the public health system. Created in 1994, the FHS covered almost 123 million individuals (63% of the Brazilian population) by 2015. The FHS has been associated with many health improvements, but gaps in coverage still remain...
January 15, 2018: Health Policy and Planning
https://www.readbyqxmd.com/read/29346421/the-absence-of-specific-yeast-heat-shock-proteins-leads-to-abnormal-aggregation-and-compromised-autophagic-clearance-of-mutant-huntingtin-proteins
#18
Ryan Higgins, Marie-Helene Kabbaj, Alexa Hatcher, Yanchang Wang
The functionality of a protein depends on its correct folding, but newly synthesized proteins are susceptible to aberrant folding and aggregation. Heat shock proteins (HSPs) function as molecular chaperones that aid in protein folding and the degradation of misfolded proteins. Trinucleotide (CAG) repeat expansion in the Huntingtin gene (HTT) results in the expression of misfolded Huntingtin protein (Htt), which contributes to the development of Huntington's disease. We previously found that the degradation of mutated Htt with polyQ expansion (Htt103QP) depends on both ubiquitin proteasome system and autophagy...
2018: PloS One
https://www.readbyqxmd.com/read/29346375/how-do-we-reach-the-girls-and-women-who-are-the-hardest-to-reach-inequitable-opportunities-in-reproductive-and-maternal-health-care-services-in-armed-conflict-and-forced-displacement-settings-in-colombia
#19
Juan Carlos Rivillas, Raul Devia Rodriguez, Gloria Song, Andréanne Martel
OBJECTIVES: This paper assesses inequalities in access to reproductive and maternal health services among females affected by forced displacement and sexual and gender-based violence in conflict settings in Colombia. This was accomplished through the following approaches: first, we assessed the gaps and gradients in three selected reproductive and maternal health care services. Second, we analyzed the patterns of inequalities in reproductive and maternal health care services and changes over time...
2018: PloS One
https://www.readbyqxmd.com/read/29346302/smart-device-based-notifications-to-promote-healthy-behavior-related-to-childhood-obesity-and-overweight
#20
Gustavo López, Iván González, Elitania Jimenez-Garcia, Jesús Fontecha, Jose A Brenes, Luis A Guerrero, José Bravo
Obesity is one of the most serious public health challenges of the 21st century and it is a threat to the life of people according to World Health Organization. In this scenario, family environment is important to establish healthy habits which help to reduce levels of obesity and control overweight in children. However, little efforts have been focused on helping parents to promote and have healthy lifestyles. In this paper, we present two smart device-based notification prototypes to promote healthy behavior with the aim of avoiding childhood overweight and obesity...
January 18, 2018: Sensors
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