keyword
https://read.qxmd.com/read/38290650/visual-rapid-and-cost-effective-bk-virus-detection-system-for-renal-transplanted-patients-using-gold-nanoparticle-coupled-loop-mediated-isothermal-amplification-nanolamp
#21
JOURNAL ARTICLE
Sunil Kumar, Srishty Raman, Kishore Sesham, Abhishek Gupta, Raj Kanwar Yadav, Asit Ranjan Mridha, Subhash Chandra Yadav
A substantial percentage of kidney transplant recipients show transplant failure due to BK virus-induced nephropathy. This can be clinically controlled by the rapid and timely detection of BK virus infection in immune-compromised patients. We report a rapid (two hours from sample collection, processing, and detection), cost-effective (< 2$), highly sensitive and BKV-specific nanoLAMP (loop-mediated isothermal amplification) diagnostic methodology using novel primers and gold nanoparticles complex-based visual detection...
January 28, 2024: Journal of Virological Methods
https://read.qxmd.com/read/38249254/clinicopathological-correlation-of-polyomavirus-nephropathy-in-renal-allograft-recipients-according-to-the-banff-2018-classification
#22
JOURNAL ARTICLE
Tamkan Junyangdikul, Ngoentra Tantranont, Thanaporn Chaiyapak, Attapong Vongwiwatana, Boonyarit Cheunsuchon
BACKGROUND: Polyomavirus nephropathy (PVN) is a rare kidney disease caused by the BK virus, a strain of polyomavirus. The disease primarily affects transplant recipients, which is related to intensive immunosuppression protocol and can lead to kidney allograft failure. OBJECTIVES: The objective of this study is to analyze histopathological features of PVN using the Banff 2018 PVN classification and to determine clinical features and outcomes of patients with PVN in each histologic class...
December 2023: Curēus
https://read.qxmd.com/read/38216361/immunoglobulin-a-deposits-in-renal-allografts-a-prospective-longitudinal-single-center-study
#23
JOURNAL ARTICLE
Kartik Ganesh, J K Jayaram, Renu Mariam Thomas, Tena Thomas Abraham, Jithin S Kumar, Sunita S Simon, M Abi Abraham
AIMS AND BACKGROUND: To describe the prevalence of IgA deposits (IgAD) in renal allografts in a cohort of renal transplant recipients and to analyze their management strategies and histopathology. To assess graft function and proteinuria after 1 year of follow-up. MATERIALS AND METHODS: A prospective longitudinal follow-up study was carried out in VPS Lakeshore Hospital and Research Centre, Kochi, Kerala, over a period of 5 years (July 2015 to June 2020). Kidney transplant recipients with allograft biopsies that reported IgAD on immunofluorescence were included in the study...
2024: Transplantation Proceedings
https://read.qxmd.com/read/38213487/protocolized-polyoma-bk-viral-load-monitoring-and-high-dose-immunoglobulin-treatment-in-children-after-kidney-transplant
#24
JOURNAL ARTICLE
Shirley Pollack, Moran Plonsky-Toder, Rami Tibi, Renata Yakubov, Irina Libinson-Zebegret, Daniella Magen
BACKGROUND: BKPyV virus nephropathy (BKPyVAN) is diagnosed in 5%-16% of pediatric renal transplant recipients (PRTR) and preceded by BKPyV-viruria and DNAemia. Despite the risk of irreversible transplant damage associated with BKPyVAN, evidence-based consensus guidelines for BKPyVAN prevention are still lacking. In this retrospective study, we examined the safety and efficacy of high-dose intravenous immunoglobulin (HD-IVIG) therapy for prevention of BKPyVAN in PRTR with significant BKPyV-viruria/DNAemia...
January 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38149668/treatment-of-bk-polyomavirus-associated-nephropathy-in-paediatric-kidney-transplant-recipients-leflunomide-versus-cidofovir
#25
JOURNAL ARTICLE
Gülşah Kaya Aksoy, Mine Erkan, Mustafa Koyun, Elif Çomak, Havva Serap Toru, Derya Mutlu, Bahar Akkaya, Sema Akman
OBJECTIVES: BK polyomavirus-associated nephropathy is a clinicopathological entity that negatively affects graft function in kidney transplant recipients. We compared the efficacy of leflunomide and cidofovir to treat BK polyomavirus-associated nephropathy in pediatric kidney transplant recipients. MATERIALS AND METHODS: Medical records of pediatric recipients with BK viremia for the period 2004 through 2019 were reviewed retrospectively, and patients diagnosed with BK polyomavirusassociated nephro-pathy were included in the study...
December 26, 2023: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38139342/acute-kidney-injury-and-bk-polyomavirus-in-urine-sediment-cells
#26
JOURNAL ARTICLE
Sahra Pajenda, Daniela Anna Gerges, Raimundo Freire, Ludwig Wagner, Zsofia Hevesi, Monika Aiad, Michael Eder, Alice Schmidt, Wolfgang Winnicki, Farsad Alexander Eskandary
Polyomaviruses are widespread, with BK viruses being most common in humans who require immunosuppression due to allotransplantation. Infection with BK polyomavirus (BKV) may manifest as BK virus-associated nephropathy and hemorrhagic cystitis. Established diagnostic methods include the detection of polyomavirus in urine and blood by PCR and in tissue biopsies via immunohistochemistry. In this study, 79 patients with pathological renal retention parameters and acute kidney injury (AKI) were screened for BK polyomavirus replication by RNA extraction, reverse transcription, and virus-specific qPCR in urine sediment cells...
December 15, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38093979/comparison-of-two-rt-qpcr-methods-targeting-bk-polyomavirus-micrornas-in-kidney-transplant-recipients
#27
JOURNAL ARTICLE
Kenza Zoubir, Véronique Descamps, Aurélien Aubry, Francois Helle, Catherine Francois, Sandrine Castelain, Etienne Brochot, Baptiste Demey
BACKGROUND: BK polyomavirus replication leads to progressive tubulointerstitial nephritis and ureteral stenosis, with a considerable risk of subsequent graft failure in kidney transplant recipients. Since specific antiviral therapies are lacking, new tools are required to enhance the biological monitoring of the infection. Viral microRNAs are promising new biomarkers, but the performance of RT-qPCR methods limits the clinical application and the validation of a standard method for quantification...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37979921/exploring-the-single-cell-immune-landscape-of-renal-allograft-inflammation-using-imaging-mass-cytometry
#28
JOURNAL ARTICLE
Mariam P Alexander, Mark Zaidi, Nicholas B Larson, Aidan Muller, Kevin Pavelko, Mark Stegall, Andrew Bentall, Bradly G Wouters, Trevor D McKee, Timucin Taner
Kidney allograft inflammation, mostly attributed to rejection and infection, is an important cause of graft injury and loss. Standard histopathological assessment of allograft inflammation provides limited insights into biological processes and immune landscape. Here, using Imaging Mass Cytometry (IMC) with a panel of 28 validated biomarkers, we explored the single-cell landscape of kidney allograft inflammation in 32 kidney transplant biopsies and 247 high-dimensional histopathology images of various phenotypes of allograft inflammation (antibody-mediated rejection, T cell-mediated rejection, BK nephropathy and chronic pyelonephritis)...
November 16, 2023: American Journal of Transplantation
https://read.qxmd.com/read/37965958/effect-of-leflunomide-on-treatment-of-pediatric-renal-transplant-recipients-with-bk-virus-infection
#29
JOURNAL ARTICLE
Evangelia Gole, Andromachi Mitsioni, Maria Darema, Georgia Malakasioti, Varvara Askiti
OBJECTIVES: Infection with the BK virus is a significant complication after renal transplant and can progress to BK virus nephropathy and graft dysfunction. There is no consensus on the management of BK virus infection in pediatric renal transplant recipients. The most common therapeutic option is immunosuppression reduction, which can increase rejection risk. We aimed to examine the effect of leflunomide, an agent with antiviral and immunosuppressive actions, in a case series of pediatric renal transplant recipients with BK virus infection...
October 2023: Experimental and Clinical Transplantation
https://read.qxmd.com/read/37965956/comparative-study-of-intravenous-immunoglobulin-and-leflunomide-combination-therapy-with-intravenous-immunoglobulin-single-therapy-in-kidney-transplant-patients-with-bk-virus-infection-single-center-clinical-trial
#30
RANDOMIZED CONTROLLED TRIAL
Nakisa Rasaei, Leila Malekmakan, Ghazal Gholamabbas, Pedram Abdizadeh
OBJECTIVES: Nephropathy due to BK virus infection is a major cause of graft dysfunction and loss. No specific treatment has been developed for the BK virus. Here, we compared the combination of intravenous immunoglobulin and leflunomide versus intravenous immunoglobulin to treat BK virus nephropathy after renal transplant. MATERIALS AND METHODS: This study was a randomized controlled clinical trial. Sixteen kidney transplant patients with BK virus infection were randomly divided into 2 groups; 1 group received intravenous immunoglobulin, and another group received leflunomide and intravenous immunoglobulin...
October 2023: Experimental and Clinical Transplantation
https://read.qxmd.com/read/37928458/case-report-jc-polyomavirus-nephropathy-in-simultaneous-heart-kidney-transplantation-the-role-of-viral-specific-in-situ-hybridization-staining
#31
Bassam G Abu Jawdeh, Maxwell L Smith, Madeline R Hudson, Girish K Mour, Pooja Budhiraja, Julie L Rosenthal
INTRODUCTION: JC polyomavirus (JCPyV) is a ubiquitous virus that can be latent in the brain and the kidney. It is the etiologic agent responsible for progressive multifocal leukoencephalopathy, a fatal, demyelinating disease of the central nervous system, and rarely causes polyomavirus nephropathy in immunocompromised kidney transplant recipients. CASE DESCRIPTION: We present the first case of JCPyV nephropathy in a simultaneous heart-kidney transplant patient, where viral-specific in situ hybridization staining of the kidney tissue was utilized to confirm the diagnosis...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37910558/viral-specific-t-cell-therapy-in-kidney-transplant-recipients-a-single-center-experience
#32
JOURNAL ARTICLE
Manish Anand, Jake Nysather, Gregory McGraw, Senu Apewokin, Ruby Khoury, Michael S Grimley, Shalini Bumb, Amit Govil
BACKGROUND: Viral infections such as adenovirus (ADV), BK virus (BKV), and cytomegalovirus (CMV) after kidney transplantation negatively impact outcomes in transplant recipients despite advancements in screening and antiviral therapy. We describe our experience of using the virus-specific T cell therapy (VSTs) in kidney transplant recipients (KTR) at our transplant center. METHODS: This is a retrospective, single center review of KTR with ADV, BKV and CMV infections between June 2021 and December 2022...
November 1, 2023: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/37907886/a-case-of-acute-kidney-injury-due-to-native-kidney-bk-polyomavirus-associated-nephropathy-in-a-human-t-lymphotropic-virus-type-1-carrier
#33
JOURNAL ARTICLE
Keita Takae, Yuki Ueno, Masumi Shojima, Hiroshi Nagae, Takako Nakano, Shohei Takata, Ritsuko Katafuchi, Kosuke Masutani, Toshiaki Nakano, Yusuke Kuroki
BACKGROUND: BK polyomavirus-associated nephropathy (BKPyVAN) has become a major cause of kidney dysfunction and graft loss in kidney transplant recipients. On rare occasion, polyomavirus has also been known to affect native kidneys of immunocompromised individuals. Only a small number of opportunistic infections have been reported in the carrier phase of human T-lymphotropic virus type 1 (HTLV-1). This is the first reported case of BKPyVAN in native kidneys of an HTLV-1 carrier. CASE PRESENTATION: A 61-year-old man was referred to our hospital from a primary care physician for work-up and treatment of pneumonia...
October 31, 2023: BMC Nephrology
https://read.qxmd.com/read/37906981/tissue-mirna-profile-is-associated-with-acute-tubular-necrosis-rejection-phenotypes-and-bk-polyomavirus-associated-nephropathy-in-human-kidney-allografts
#34
JOURNAL ARTICLE
Neva Bezeljak, Nika Kojc, Zeljka Veceric Haler, Miha Arnol, Emanuela Boštjančič
INTRODUCTION: MicroRNAs, short noncoding RNAs, are involved in the modulation of gene expression, mainly by inhibiting the translation of mRNAs. Under physiological conditions, miRNAs are involved in viral infections and immune responses, among others; aberrant miRNA expression has been associated with kidney transplant pathologies, but a comprehensive comparison of later, particularly in tissue sections, is still pending. METHODS: We used the genome-wide screening of miRNAs to identify those potentially involved in the disease processes after kidney transplantation...
October 31, 2023: Nephron
https://read.qxmd.com/read/37886738/human-bkv-large-t-genome-detection-in-prostate-cancer-and-benign-prostatic-hyperplasia-tissue-samples-by-nested-pcr-a-case-control-study
#35
JOURNAL ARTICLE
Narges Tavassoli, Arastoo Vojdani, Sara Salimi-Namin, Majid Khadem-Rezaiyan, Mahmoudreza Kalantari, Masoud Youssefi
Human BK polyomavirus (BKPyV) is a latent infectious agent in the genitourinary tract associated with hemorrhagic cystitis and nephropathy. This virus can be a risk factor for various human malignancies, including prostate cancer (PCa). It may contribute to prostate cancer development, as it demonstrates oncogenic properties by encoding oncoproteins. This study assessed the prevalence of this virus in benign and malignant prostate tissues. Between 2009 and 2019, 49 formalin-fixed paraffin-embedded (FFPE) PCa and 49 benign prostatic hyperplasia (BPH) samples were gathered from the pathology department of a tertiary care university hospital...
2023: Molecular Biology Research Communications
https://read.qxmd.com/read/37885288/predictive-factors-of-bk-virus-development-in-kidney-transplant-recipients-and-the-effect-of-low-dose-tacrolimus-plus-everolimus-on-clinical-outcomes
#36
JOURNAL ARTICLE
Vural Taner Yilmaz, Abdullah Kisaoglu, Ali Avanaz, Ozgur Dandin, Deniz Ozel, Derya Mutlu, Bahar Akkaya, Bulent Aydinli, Huseyin Kocak
OBJECTIVES: This study aimed to determine the predictive factors of BK virus viremia/nephropathy in kidney transplant recipients and to evaluate the effects of low-dose tacrolimus plus everolimus. MATERIALS AND METHODS: This study included 3654 kidney transplant recipients. The patients were divided into 2 groups: group 1 were BK virus negative (n = 3525, 96.5%) and group 2 were BK virus positive (n = 129, viremia 3.5%, nephropathy 1%). Predictive factors were determined by receiver operating characteristic curve analysis and logistic regression models...
September 2023: Experimental and Clinical Transplantation
https://read.qxmd.com/read/37878180/nephrology-picture-c4d-positive-tubules-in-severe-bk-virus-nephropathy
#37
JOURNAL ARTICLE
Kanza Haq, Silvia Malvica, Avi Rosenberg, Sam Kant
No abstract text is available yet for this article.
October 25, 2023: Journal of Nephrology
https://read.qxmd.com/read/37793014/management-of-severe-bk-viremia-in-a-patient-receiving-a-kidney-transplant-from-a-hepatitis-c-virus-positive-donor-a-case-report
#38
JOURNAL ARTICLE
Megan Gray, Leanna Borges, Meagan Conrath, Kristen Marti
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: A case of BK nephropathy in a kidney transplant recipient who received an organ from a hepatitis C virus (HCV)-positive donor is reported...
October 4, 2023: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/37778932/the-importance-of-1-year-protocol-biopsy-in-the-long-term-prognosis-of-kidney-transplants-5-years-follow-up
#39
JOURNAL ARTICLE
Aleksandra Cieślik, Anna Burban, Michał Gniewkiewicz, Jolanta Gozdowska, Dominika Dęborska-Materkowska, Agnieszka Perkowska-Ptasinska, Maciej Kosieradzki, Magdalena Durlik
BACKGROUND: Protocol biopsies are performed to detect subclinical pathologies that may lead to future graft dysfunction. However, they are not routinely performed interventions in every transplant center. There is no established regimen for performing them. PURPOSE: The study aimed to evaluate if protocol biopsies can improve long-term patient outcomes after detecting early disorders and modifying treatment. MATERIAL AND METHODS: Our observational study included 61 patients who underwent protocol biopsy 12 months after the transplantation...
September 29, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37771695/bk-polyomavirus-latency-reactivation-diseases-and-tumorigenesis
#40
REVIEW
Xianfeng Zhou, Chunlong Zhu, Hui Li
The identification of the first human polyomavirus BK (BKV) has been over half century, The previous epidemiological and phylogenetic studies suggest that BKV prevailed and co-evolved with humans, leading to high seroprevalence all over the world. In general, BKV stays latent and symptomless reactivation in healthy individuals. BKV has been mainly interlinked with BKV-associated nephropathy (BKVAN) in kidney-transplant recipients and hemorrhagic cystitis (HC) in hematopoietic stem cell transplant recipients (HSCTRs)...
2023: Frontiers in Cellular and Infection Microbiology
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