Mariam P Alexander, Mark Zaidi, Nicholas B Larson, Aidan Muller, Kevin Pavelko, Mark Stegall, Andrew Bentall, Bradly G Wouters, Trevor D McKee, Timucin Taner
Kidney allograft inflammation, mostly attributed to rejection and infection, is an important cause of graft injury and loss. Standard histopathological assessment of allograft inflammation provides limited insights into biological processes and immune landscape. Here, using Imaging Mass Cytometry (IMC) with a panel of 28 validated biomarkers, we explored the single-cell landscape of kidney allograft inflammation in 32 kidney transplant biopsies and 247 high-dimensional histopathology images of various phenotypes of allograft inflammation (antibody-mediated rejection, T cell-mediated rejection, BK nephropathy and chronic pyelonephritis)...
November 16, 2023: American Journal of Transplantation