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https://www.readbyqxmd.com/read/28528376/isometric-handgrip-as-an-adjunct-for-blood-pressure-control-a-primer-for-clinicians
#1
REVIEW
Cheri L McGowan, David N Proctor, Ian Swaine, Robert D Brook, Elizabeth A Jackson, Phillip D Levy
Considered a global health crisis by the World Health Organization, hypertension (HTN) is the leading risk factor for death and disability. The majority of treated patients do not attain evidence-based clinical targets, which increases the risk of potentially fatal complications. HTN is the most common chronic condition seen in primary care; thus, implementing therapies that lower and maintain BP to within-target ranges is of tremendous public health importance. Isometric handgrip (IHG) training is a simple intervention endorsed by the American Heart Association as a potential adjuvant BP-lowering treatment...
June 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28528077/is-the-success-of-the-slimmer-diabetes-prevention-intervention-modified-by-socioeconomic-status-a-randomised-controlled-trial
#2
Andrea J Bukman, Geerke Duijzer, Annemien Haveman-Nies, Sophia C Jansen, Josien Ter Beek, Gerrit J Hiddink, Edith J M Feskens
AIM: To explore the role of socioeconomic status (SES) in participation, programme attendance, programme acceptability, adherence to lifestyle guidelines, drop-out, and effectiveness in the SLIMMER diabetes prevention intervention. METHODS: SLIMMER was a randomised controlled intervention, carried out in a real-world setting, targeting 40- to 70-year-old adults at increased risk of developing type 2 diabetes (n=316). The intervention group participated in a 10-month combined dietary and physical activity programme...
May 10, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28528075/adopting-the-new-world-health-organization-diagnostic-criteria-for-gestational-diabetes-how-the-prevalence-changes-in-a-high-risk-region-in-australia
#3
Vincent W Wong, Andrew Lin, Hamish Russell
AIMS: In this study, we assessed changes in prevalence of gestational diabetes mellitus (GDM) in a region with diverse cultural backgrounds in Australia under the new World Health Organization (WHO) diagnostic criteria, with reference to the woman's ethnicity, age and pre-pregnant body mass index (BMI). METHODS: We recorded results of all 75-gram oral glucose tolerance tests (OGTTs) performed on pregnant women between February and December 2015 together with their demographic details, and determined the prevalence of GDM based on the old Australian Diabetes in Pregnancy Society (ADIPS) and the new WHO criteria respectively...
April 25, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28527973/molecular-analysis-of-group-a-rotaviruses-detected-in-hospitalized-children-from-rawalpindi-pakistan-during-2014
#4
Massab Umair, Bilal Haider Abbasi, Nadia Nisar, Muhammad Masroor Alam, Salmaan Sharif, Shahzad Shaukat, Muhammad Suleman Rana, Adnan Khurshid, Ghulam Mujtaba, Uzma Bashir Aamir, Syed Sohail Zahoor Zaidi
As part of strategy to control diarrheal diseases, World Health Organization (WHO) recommends to include rotavirus vaccines in national immunization programs. Sentinel surveillance networks have been established to monitor rotavirus disease burden and genotype distribution in both pre and post vaccine era in many countries. Unfortunately due to lack of proper surveillance programs, data on rotavirus disease burden and genotype distribution from Pakistan is scarce. We investigated 502 stool samples from children (<5years) hospitalized due to gastroenteritis in Rawalpindi, Pakistan during 2014 for the presence of group A rotavirus (RVA) and its genotypic diversity...
May 17, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28527959/systemic-treatment-patterns-with-advanced-or-recurrent-non-small-cell-lung-cancer-in-japan-a-retrospective-hospital-administrative-database-study
#5
Feng Wang, Sari Mishina, Shinji Takai, T Kim Le, Kenya Ochi, Kotaro Funato, Shozo Matsuoka, Yuichiro Ohe
PURPOSE: Data on the treatment of non-small cell lung cancer (NSCLC) in real-world clinical practice in Japan are limited. This large-scale, retrospective cohort study examined data on patients' characteristics and systemic therapies for advanced or recurrent NSCLC in routine practice in Japan. METHODS: This study used an electronic health records-based database of health claims and Diagnosis Procedure Combination data from 215 consenting hospitals in Japan. Records from April 2008 to September 2015 were analyzed...
May 18, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28527886/immuno-pcr-a-new-technique-for-the-serodiagnosis-of-tuberculosis
#6
REVIEW
Promod K Mehta, Bhawna Dahiya, Suman Sharma, Netrapal Singh, Renu Dharra, Zoozeal Thakur, Neeru Mehta, Krishna B Gupta, Mahesh C Gupta, Dhruva Chaudhary
Rapid and accurate diagnosis of tuberculosis (TB) is essential to control the disease. The conventional microbiological tests have limitations and there is an urgent need to devise a simple, rapid and reliable point-of-care (POC) test. The failure of TB diagnostic tests based on antibody detection due to inconsistent and imprecise results has stimulated renewed interest in the development of rapid antigen detection methods. However, the World Health Organization (WHO) has emphasized to continue research for designing new antibody-based detection tests with improved accuracy...
May 17, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28527741/reeling-in-the-damages-harmful-algal-blooms-impact-on-lake-erie-s-recreational-fishing-industry
#7
David Wolf, Will Georgic, H Allen Klaiber
Lake Erie is one of the most valuable natural resources in the United States, providing billions of dollars in benefits each year to recreationalists, homeowners and local governments. The ecosystem services provided by Lake Erie, however, are under threat due to harmful algal blooms. This paper provides recreational damage estimates using spatially and temporally varying algae measures and monthly fishing permit sales collected between 2011 and 2014. Results indicate that fishing license sales drop between 10% and 13% when algal conditions surpass the World Health's Organization's moderate health risk advisory threshold of 20,000 cyanobacteria cells/mL...
May 18, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28527687/cost-effectiveness-analysis-of-typhoid-conjugate-vaccines-in-five-endemic-low-and-middle-income-settings
#8
Marina Antillón, Joke Bilcke, A David Paltiel, Virginia E Pitzer
BACKGROUND: Typhoid fever remains endemic in low- and middle-income countries. Programmatic use of existing vaccines is limited, but upcoming typhoid conjugate vaccines (TCVs) could warrant wider use. We evaluated the cost-effectiveness of five TCV delivery strategies in three urban areas (Delhi and Kolkata, India and Nairobi, Kenya) and two rural settings (Lwak, Kenya and Dong Thap, Vietnam) with varying incidence. METHODS AND FINDINGS: We evaluated routine infant vaccination with and without catch-up campaigns among older individuals...
May 17, 2017: Vaccine
https://www.readbyqxmd.com/read/28527636/shared-decision-making-in-west-africa-the-forgotten-area
#9
Ndeye Thiab Diouf, Ali Ben Charif, Lionel Adisso, Rhéda Adekpedjou, Hervé Tchala Vignon Zomahoun, Tatiana Titilayo Agbadjé, Mama Joyce Dogba, Mirjam Marjolein Garvelink
Up to now, little attention has been paid to West Africa when it comes to shared decision making (SDM). West African countries seem to lag behind with regard to SDM initiatives compared to many other countries in the world. There is some interest in informed decision-making or informed consent, but little in a full SDM process. Few decision-making tools are available for healthcare professionals and the majority are not designed to support decision-making with patients. Furthermore, to the best of our knowledge, there are no training programs for implementing SDM in healthcare teams...
May 18, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28527533/global-regional-and-national-burden-of-cardiovascular-diseases-for-10-causes-1990-to-2015
#10
Gregory A Roth, Catherine Johnson, Amanuel Abajobir, Foad Abd-Allah, Semaw Ferede Abera, Gebre Abyu, Muktar Ahmed, Baran Aksut, Tahiya Alam, Khurshid Alam, François Alla, Nelson Alvis-Guzman, Stephen Amrock, Hossein Ansari, Johan Ärnlöv, Hamid Asayesh, Tesfay Mehari Atey, Leticia Avila-Burgos, Ashish Awasthi, Amitava Banerjee, Aleksandra Barac, Till Bärnighausen, Lars Barregard, Neeraj Bedi, Ezra Belay Ketema, Derrick Bennett, Gebremedhin Berhe, Zulfiqar Bhutta, Shimelash Bitew, Jonathan Carapetis, Juan Jesus Carrero, Deborah Carvalho Malta, Carlos Andres Castañeda-Orjuela, Jacqueline Castillo-Rivas, Ferrán Catalá-López, Jee-Young Choi, Hanne Christensen, Massimo Cirillo, Leslie Cooper, Michael Criqui, David Cundiff, Albertino Damasceno, Lalit Dandona, Rakhi Dandona, Kairat Davletov, Samath Dharmaratne, Prabhakaran Dorairaj, Manisha Dubey, Rebecca Ehrenkranz, Maysaa El Sayed Zaki, Emerito Jose A Faraon, Alireza Esteghamati, Talha Farid, Maryam Farvid, Valery Feigin, Eric L Ding, Gerry Fowkes, Tsegaye Gebrehiwot, Richard Gillum, Audra Gold, Philimon Gona, Rajeev Gupta, Tesfa Dejenie Habtewold, Nima Hafezi-Nejad, Tesfaye Hailu, Gessessew Bugssa Hailu, Graeme Hankey, Hamid Yimam Hassen, Kalkidan Hassen Abate, Rasmus Havmoeller, Simon I Hay, Masako Horino, Peter J Hotez, Kathryn Jacobsen, Spencer James, Mehdi Javanbakht, Panniyammakal Jeemon, Denny John, Jost Jonas, Yogeshwar Kalkonde, Chante Karimkhani, Amir Kasaeian, Yousef Khader, Abdur Khan, Young-Ho Khang, Sahil Khera, Abdullah T Khoja, Jagdish Khubchandani, Daniel Kim, Dhaval Kolte, Soewarta Kosen, Kristopher J Krohn, G Anil Kumar, Gene Kwan, Dharmesh Kumar Lal, Anders Larsson, Shai Linn, Alan Lopez, Paulo A Lotufo, Hassan Magdy Abd El Razek, Reza Malekzadeh, Mohsen Mazidi, Toni Meier, Kidanu Gebremariam Meles, George Mensah, Atte Meretoja, Haftay Mezgebe, Ted Miller, Erkin Mirrakhimov, Shafiu Mohammed, Andrew E Moran, Kamarul Imran Musa, Jagat Narula, Bruce Neal, Frida Ngalesoni, Grant Nguyen, Carla Makhlouf Obermeyer, Mayowa Owolabi, George Patton, João Pedro, Dima Qato, Mostafa Qorbani, Kazem Rahimi, Rajesh Kumar Rai, Salman Rawaf, Antônio Ribeiro, Saeid Safiri, Joshua A Salomon, Itamar Santos, Milena Santric Milicevic, Benn Sartorius, Aletta Schutte, Sadaf Sepanlou, Masood Ali Shaikh, Min-Jeong Shin, Mehdi Shishehbor, Hirbo Shore, Diego Augusto Santos Silva, Eugene Sobngwi, Saverio Stranges, Soumya Swaminathan, Rafael Tabarés-Seisdedos, Niguse Tadele Atnafu, Fisaha Tesfay, J S Thakur, Amanda Thrift, Roman Topor-Madry, Thomas Truelsen, Stefanos Tyrovolas, Kingsley Nnanna Ukwaja, Olalekan Uthman, Tommi Vasankari, Vasiliy Vlassov, Stein Emil Vollset, Tolassa Wakayo, David Watkins, Robert Weintraub, Andrea Werdecker, Ronny Westerman, Charles Shey Wiysonge, Charles Wolfe, Abdulhalik Workicho, Gelin Xu, Yuichiro Yano, Paul Yip, Naohiro Yonemoto, Mustafa Younis, Chuanhua Yu, Theo Vos, Mohsen Naghavi, Christopher Murray
BACKGROUND: The burden of cardiovascular diseases (CVDs) remains unclear in many regions of the world. OBJECTIVES: The GBD (Global Burden of Disease) 2015 study integrated data on disease incidence, prevalence, and mortality to produce consistent, up-to-date estimates for cardiovascular burden. METHODS: CVD mortality was estimated from vital registration and verbal autopsy data. CVD prevalence was estimated using modeling software and data from health surveys, prospective cohorts, health system administrative data, and registries...
May 15, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28527482/-scientific-research-policy-for-health-in-portugal-i-european-and-national-environment
#11
REVIEW
Cátia Sá Guerreiro, Zulmira Hartz, Luís Sambo, Cláudia Conceição, Gilles Dussault, Giuliano Russo, Miguel Viveiros, Henrique Silveira, Pedro Pita Barros, Paulo Ferrinho
The global debate on scientific research policy for human health has been led by World Health Organisation with important contributions from other stakeholders such as Council on Health Research for Development, the World Bank and the Global Forum for Health Research. Recently it has been dominated by the thematic agendas of major global financiers. There is a growing interest worldwide in making better use of the evidence resulting from scientific research in health, in the decision-making process regarding health policies, which is fraught with difficulties, as it is the case in Europe...
February 27, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28527473/presence-of-new-mutations-in-the-tp53-gene-in-patients-with-low-risk-myelodysplastic-syndrome-two-case-reports
#12
Fernando Barroso Duarte, Romélia Pinheiro Gonçalves Lemes, Talyta Ellen de Jesus Dos Santos, Maritza Cavalcante Barbosa, João Paulo Leitão de Vasconcelos, Francisco Dário Rocha-Filho, Ilana Zalcberg, Diego Coutinho, Monalisa Feliciano Figueiredo, Luciana Barros Carlos, Paulo Roberto Leitão de Vasconcelos
BACKGROUND: Myelodysplastic syndromes are heterogeneous disorders. Patients with myelodysplastic syndrome disease often have ineffective hematopoiesis, cytopenias, blood cell dysplasia in one or more cell types, and are at high risk for developing acute myeloid leukemia. In myelodysplastic syndrome, mutations of TP53 gene are usually associated with complex karyotype and confer a worse prognosis. In the present study, two mutations in this gene are presented and discussed with the clinical evolution of the patients...
May 21, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28527379/diagnosing-water-security-in-the-rural-north-with-an-environmental-security-framework
#13
Henry J F Penn, Philip A Loring, William E Schnabel
This study explores the nature of water security challenges in rural Alaska, using a framework for environmental security that entails four interrelated concepts: availability, access, utility, and stability of water resources. Many researchers and professionals agree that water insecurity is a problem in rural Alaska, although the scale and nature of the problem is contested. Some academics have argued that the problem is systemic, and rooted in an approach to water security by the state that prioritizes economic concerns over public health concerns...
May 17, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28527285/-genetic-diversity-of-extraintestinal-escherichia-coli-strains-producers-of-beta-lactamases-tem-shv-and-ctx-m-associated-with-healthcare
#14
Yasmin Varela, Beatriz Millán, María Araque
INTRODUCTION: There are few reports from Venezuela describing the genetic basis that sustains the pathogenic potential and phylogenetics of Escherichia coli extraintestinal strains isolated in health care units. OBJECTIVE: To establish the genetic diversity of extraintestinal E. coli strains producers of betalactamases TEM, SHV and CTX-M associated with healthcare. MATERIALS AND METHODS: We studied a collection of 12 strains of extraintestinal E...
June 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527280/-pperformance-of-led-fluorescence-microscopy-for-the-detection-of-acid-fast-bacilli-from-respiratory-samples-in-peripheral-laboratories-in-argentina
#15
María Imaz, Sonia Allassia, Mónica Aranibar, Alba Gunia, Susana Poggi, Ana Togneri, Lidia Wolff, Group Of Implementation Of Fluorescence
INTRODUCTION: Light-emitting diode fluorescence microscopy (LED-FM) has been endorsed by the World Health Organization (WHO) for tuberculosis diagnosis, but its accuracy in HIV-infected patients remains controversial, and only some few studies have explored procedural factors that may affect its performance. OBJECTIVE: To evaluate the performance of LED-FM for tuberculosis diagnosis in patients with and without HIV infection using a newer, less expensive LED lamp...
June 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527253/-prevalence-of-mycobacterium-tuberculosis-resistance-to-quinolones-and-injectables-in-colombia-2012-2013
#16
Claudia Llerena, Angie Zabaleta, Angélica Valbuena, Martha Murcia
INTRODUCTION: Tuberculosis is a health problem worldwide. The World Health Organization estimated 9.6 million new cases and 480,000 multirresistant cases for 2014. The assessment of resistance to quinolones and injectables was implemented only a few years ago, so its prevalence is not known. OBJECTIVE: To determine the prevalence of resistance to amikacin, capreomycin and ofloxacin in cases of tuberculosis resistant to isoniazid and/or rifampin during 2012-2013...
January 24, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527249/-sociodemographic-and-clinical-characteristics-of-patients-infected-with-leptospira-spp-treated-at-four-hospitals-in-medell%C3%A3-n-colombia-2008-2013
#17
Lina María Echeverri-Toro, Sara Penagos, Laura Castañeda, Pablo Villa, Santiago Atehortúa, Faiver Ramírez, Carlos Restrepo, Sigifredo Ospina, Yuli Agudelo, Alicia Hidrón, Paola Agudelo, Eliana Valderrama, Carlos Andrés Agudelo
INTRODUCTION: Leptospirosis remains a significant health problem in tropical regions including Latin America, where its presentation is 100 times higher than that observed in other regions of the world. Mortality reaches 10% in severe cases. Its diagnosis is challenging because clinical manifestations during the initial phase are non-specific and because of limited availability of diagnostic tests. OBJECTIVE: To describe the demographic and clinical characteristics and the outcomes in hospitalized patients with leptospirosis...
January 24, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527245/-description-of-mycobacterium-tuberculosis-mutations-conferring-resistance-to-rifampicin-and-isoniazid-detected-by-genotype%C3%A2-mtbdrplus-v-2-in-colombia
#18
Claudia Llerena, Raquel Medina
INTRODUCTION: The GenoType®MTBDRplusV.2 assay is a molecular technique endorsed by the World Health Organization and the Pan American Health Organization that allows for the identification of the Mycobacterium tuberculosis complex and the detection of mutations in the rpoβ gene for rifampicin resistance, and katG and inhA genes for isoniazid resistance. Due to the genetic variability in the circulating strains around the world, the national tuberculosis control programs should assess the performance of these new diagnostic technologies and their use under program conditions as rapid tests...
January 24, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28526789/a-novel-iron-dependent-enzyme-that-catalyzes-the-initial-step-in-the-biodegradation-of-n-nitroglycine-by-variovorax-sp-strain-js1663
#19
Kristina M Mahan, Hangping Zheng, Tekle T Fida, Ronald J Parry, David E Graham, Jim C Spain
Nitramines are key constituents of most of the explosives in current use and consequently contaminate soil and groundwater at many military facilities around the world. Toxicity from nitramine contamination poses a health risk to plants and animals, thus understanding how nitramines are biodegraded is critical to environmental remediation. The biodegradation of synthetic nitramine compounds such as hexahydro-1,3,5-trinitro-1,3,5- triazine (RDX) has been studied for decades, but little is known about the catabolism of naturally produced nitramine compounds...
May 19, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28526721/health-care-resource-utilization-and-associated-costs-among-metastatic-cutaneous-melanoma-patients-treated-with-ipilimumab-intuition-study
#20
Grant A McArthur, Peter Mohr, Paolo Antonio Ascierto, Ana Arance, Ana Banos Hernaez, Peter Kaskel, Michael Weichenthal, Reshma Shinde, Kendall Stevinson
BACKGROUND: There are limited real-world data on health care resource utilization (HCRU) among advanced melanoma patients. The objective of this study was to describe HCRU and health care costs associated with the management of advanced melanoma patients receiving ipilimumab. METHODS: This retrospective multinational, observational study included advanced melanoma patients from Australia, Germany, Italy, and Spain who had received at least 1 dose of ipilimumab. Data extracted from medical charts included inpatient admissions, outpatient visits, surgical procedures, laboratory investigations, radiation therapy, imaging studies, and concomitant medications...
May 19, 2017: Oncologist
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