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https://www.readbyqxmd.com/read/28214961/obesity-and-kidney-disease-hidden-consequences-of-the-epidemic
#1
EDITORIAL
Csaba P Kovesdy, Susan L Furth, Carmine Zoccali
Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease and also for Chronic Kidney Disease. A high body mass index is one of the strongest risk factors for new-onset Chronic Kidney Disease. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing Chronic Kidney Disease in the long-term...
February 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/28214572/clinical-relevance-of-oxidation-reduction-potential-in-the-evaluation-of-male-infertility
#2
Ashok Agarwal, Siew May Wang
Objectives To evaluate 1) the relationship between oxidation-reduction potential (ORP) and abnormal sperm quality, 2) changes in ORP and sperm parameters over time, in search of a potential surrogate marker of poor sperm quality that may assist in the diagnosis of oxidative stress- related male infertility. Methods 194 infertile men were included and 28 patients were identified to have repeated semen analyses and ORP measurements. The semen samples obtained were categorized into normal and abnormal sperm parameters based on the World Health Organization (WHO) 5(th) edition guidelines...
February 15, 2017: Urology
https://www.readbyqxmd.com/read/28214473/pacific-island-health-inequities-forecast-to-grow-unless-profound-changes-are-made-to-health-systems-in-the-region
#3
Don Matheson, Kunhee Park, Taniela Sunia Soakai
Objective Twenty years ago the Pacific's health ministers developed a 'Healthy Islands' vision to lead health development in the subregion. This paper reports on a review of health development over this period and discusses the implications for the attainment of the health related Sustainable Development Goals.Methods The review used qualitative and quantitative methods. The qualitative review included conducting semi-structured interviews with Pacific Island Government Ministers and officials, regional agencies, health workers and community members...
February 20, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28214237/knowledge-attitudes-and-preferences-of-advance-decisions-end-of-life-care-and-place-of-care-and-death-in-hong-kong-a%C3%A2-population-based-telephone-survey-of-1067-adults
#4
Roger Yat-Nork Chung, Eliza Lai-Yi Wong, Nicole Kiang, Patsy Yuen-Kwan Chau, Janice Y C Lau, Samuel Yeung-Shan Wong, Eng-Kiong Yeoh, Jean W Woo
OBJECTIVES: According to the 2015 Quality of Death Index published by the Intelligence Unit of the Economist, Hong Kong is ranked 22nd in terms of quality of palliative care in the world, behind many other major developed countries in Asia, including Taiwan, Singapore, Japan, and South Korea. The objectives of the present study were to describe the knowledge, attitude, and preferences of the general Hong Kong adult population across different age groups regarding end-of-life (EOL) care decisions, place of care and death, as well as advance directive (AD)...
February 14, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28214229/-iso%C3%A2-9001%C3%A2-certification-of-innovation-and-clinical-research-departments-extending-the-scope-of-health-assessment
#5
C Sambou, S Guillemaut, M Morelle, A Achache, A-G Le Corroller, D Perol, L Perrier
BACKGROUND: The International organization for standardization (ISO) is the world leader in providing industrial and commercial standards and certifications. Beyond medical devices, four French clinical research and innovation departments have received an ISO 9001 certification (the standard for quality management). Simultaneously, medico-economic studies have become increasingly important in the public decision process. Using the clinical research and innovation department from the Léon-Bérard Cancer Center as an example, the purpose of this article is to show how the scope of the ISO 9001 certification has been extended to cover medico-economic studies...
February 14, 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/28213689/serious-fungal-infections-in-egypt
#6
S M Zaki, D W Denning
We aimed to estimate the burden of serious fungal infections in Egypt, currently unknown, based on the size of the populations at risk and available epidemiological data. Data were obtained from the World Health Organization (WHO), the Joint United Nations Programme on HIV/AIDS (UNAIDS), and published reports with clearcut denominators. When no data existed, risk populations were used to estimate frequencies of fungal infections, using previously described methodology. The population of Egypt in 2011 was ∼82,500,000; 31% children, and 8% women >60 years of age...
February 17, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28213617/world-federation%C3%A2-of-public-health-associations-50%C3%A2-years-of-international%C3%A2-leadership-for-a-healthy-global-society
#7
James Chauvin, Margaret Hilson, Russell E Morgan
No abstract text is available yet for this article.
February 17, 2017: Journal of Public Health Policy
https://www.readbyqxmd.com/read/28213608/trends-in-anthropometric-measures-among-us-children-6-to-23-months-1976-2014
#8
Lara J Akinbami, Brian K Kit, Margaret D Carroll, Tala H I Fakhouri, Cynthia L Ogden
BACKGROUND AND OBJECTIVES: The surveillance of children's growth reflects a population's nutritional status and risk for adverse outcomes. This study aimed to describe trends in length-for-age, weight-for-age, weight-for-length, and early childhood weight gain among US children aged 6 to 23 months. METHODS: We analyzed NHANES data from 1976-1980, 1988-1994, 1999-2002, 2003-2006, 2007-2010, and 2011-2014. We estimated z scores < -2 (low) and ≥+2 (high) in comparison with World Health Organization growth standards for each indicator...
February 17, 2017: Pediatrics
https://www.readbyqxmd.com/read/28213597/retrospective-examination-of-lipid-lowering-treatment-patterns-in-a-real-world-high-risk-cohort-in-the-uk-in-2014-comparison-with-the-national-institute-for-health-and-care-excellence-nice-2014-lipid-modification-guidelines
#9
Dylan L Steen, Irfan Khan, David Ansell, Robert J Sanchez, Kausik K Ray
BACKGROUND: In 2014, guidelines from the National Institute for Health and Care Excellence (NICE) provided updated recommendations on lipid-modifying therapy (LMT). We assessed clinical practice contemporaneous to release of these guidelines in a UK general practice setting for secondary and high-risk primary-prevention populations, and extrapolated the findings to UK nation level. METHODS: Patients from The Health Improvement Network database with the following criteria were included: lipid profile in 2014 (index date); ≥20 years of age; ≥2 years representation in database prior to index; ≥1 statin indication either for atherosclerotic cardiovascular disease (ASCVD) or the non-ASCVD conditions high-risk diabetes mellitus and/or chronic kidney disease...
February 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28213479/impact-of-searching-clinical-trial-registries-in-systematic-reviews-of-pharmaceutical-treatments-methodological-systematic-review-and-reanalysis-of-meta-analyses
#10
Marie Baudard, Amélie Yavchitz, Philippe Ravaud, Elodie Perrodeau, Isabelle Boutron
Objective To evaluate the impact of searching clinical trial registries in systematic reviews.Design Methodological systematic review and reanalyses of meta-analyses.Data sources Medline was searched to identify systematic reviews of randomised controlled trials (RCTs) assessing pharmaceutical treatments published between June 2014 and January 2015. For all systematic reviews that did not report a trial registry search but reported the information to perform it, the World Health Organization International Trials Registry Platform (WHO ICTRP search portal) was searched for completed or terminated RCTs not originally included in the systematic review...
February 17, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28213143/selective-detection-of-cu-2-and-co-2-in-aqueous-media-asymmetric-chemosensors-crystal-structure-and-spectroscopic-studies
#11
Samira Gholizadeh Dogaheh, Hamid Khanmohammadi, E Carolina Sañudo
Two new azo-azomethine receptors, H2L(1) and H2L(2), containing hydrazine, naphthalene and different electron withdrawing groups, Cl and NO2, have been designed and synthesized for qualitative and quantitative detection of Cu(2+) and Co(2+) in aqueous media. The crystal structure of H2L(1)is reported. The H2L(1)was used as a chemosensor for selective detection of trace amount of Cu(2+) in aqueous media. H2L(2) was also applied to naked-eye distinction of Cu(2+) and Co(2+) from other transition metal ions in aqueous media...
February 8, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28213047/the-effect-of-combined-aspirin-and-clopidogrel-treatment-on-cancer-incidence
#12
Avi Leader, Ravit Zelikson-Saporta, David Pereg, Galia Spectre, Uri Rozovski, Pia Raanani, Doron Hermoni, Michael Lishner
BACKGROUND: Multiple studies have shown an association between aspirin treatment and a reduction in newly diagnosed cancer. Conversely, there are conflicting clinical and laboratory data regarding the effect of combined clopidogrel and aspirin therapy on cancer incidence, including analyses suggesting an increased cancer risk. No large scale cohort study has been performed to address this issue in a heterogeneous real-world scenario. We investigated the effect of clopidogrel and aspirin on cancer incidence compared to aspirin alone and no antiplatelet therapy...
February 14, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28213044/hepatocellular-carcinoma-screening-associated-with-early-tumor-detection-and-improved-survival-among-patients-with-cirrhosis-in-the-united-states
#13
Amit G Singal, Sahil Mittal, Olutola A Yerokun, Chul Ahn, Jorge Marrero, Adam Yopp, Neehar D Parikh, Steve J Scaglione
BACKGROUND: Professional societies recommend hepatocellular carcinoma screening in patients with cirrhosis but high-quality data evaluating its effectiveness to improve early tumor detection and survival in "real world" clinical practice are needed. AIMS: Characterize the association between hepatocellular carcinoma screening and early tumor detection, curative treatment, and overall survival among patients with cirrhosis. METHODS: We performed a retrospective cohort study of patients diagnosed with hepatocellular carcinoma between June 2012 and May 2013 at four health systems in the United States...
February 14, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28213000/obesity-is-associated-with-long-term-improved-survival-in-definitively-treated-locally-advanced-non-small-cell-lung-cancer-nsclc
#14
Vincent K Lam, Søren M Bentzen, Pranshu Mohindra, Elizabeth M Nichols, Neha Bhooshan, Melissa Vyfhuis, Katherine A Scilla, Steven J Feigenberg, Martin J Edelman, Josephine L Feliciano
OBJECTIVES: To determine the prognostic effect of Body Mass Index (BMI) in definitively treated locally advanced NSCLC patients. MATERIALS AND METHODS: In this single institution retrospective cohort study, we evaluated 291 patients who were treated for locally advanced NSCLC from 2000 to 2010. They were stratified into four BMI groups based on World Health Organization criteria: underweight (<18.5kg/m2), normal weight (18.5 to <25kg/m2), overweight (25 to <30kg/m2), and obese (≧30kg/m2)...
February 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28212969/lessons-learned-when-introducing-pharmacogenomic-panel-testing-into-clinical-practice
#15
Marc B Rosenman, Brian Decker, Kenneth D Levy, Ann M Holmes, Victoria M Pratt, Michael T Eadon
OBJECTIVES: Implementing new programs to support precision medicine in clinical settings is a complex endeavor. We describe challenges and potential solutions based on the Indiana GENomics Implementation: an Opportunity for the Underserved (INGenious) program at Eskenazi Health-one of six sites supported by the Implementing GeNomics In pracTicE network grant of the National Institutes of Health/National Human Genome Research Institute. INGenious is an implementation of a panel of genomic tests...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28212961/mapping-to-estimate-health-state-utility-from-non-preference-based-outcome-measures-an-ispor-good-practices-for-outcomes-research-task-force-report
#16
Allan J Wailoo, Monica Hernandez-Alava, Andrea Manca, Aurelio Mejia, Joshua Ray, Bruce Crawford, Marc Botteman, Jan Busschbach
Economic evaluation conducted in terms of cost per quality-adjusted life-year (QALY) provides information that decision makers find useful in many parts of the world. Ideally, clinical studies designed to assess the effectiveness of health technologies would include outcome measures that are directly linked to health utility to calculate QALYs. Often this does not happen, and even when it does, clinical studies may be insufficient for a cost-utility assessment. Mapping can solve this problem. It uses an additional data set to estimate the relationship between outcomes measured in clinical studies and health utility...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28212936/antihyperlipidemic-and-hepatoprotective-properties-of-selenium-modified-polysaccharide-from-lachnum-sp
#17
Maheen Mahwish Surhio, Yufen Wang, Ping Xu, Shah Faisal, Jinglei Li, Ming Ye
Hyperlipidemia is one of the major health problem people suffering throughout the world, which is also a major risk factor for chronic heart disease that can lead to death. The current study was designed to investigate antihyperlipidemic and hepatoprotective effects of selenium modified exopolysaccharide of Lachnum sp (SeLEP-1b) on high-fat induced mice model. Nitric acid-sodium selenite (HNO3-Na2SeO3) method was used to selenize pure LEP-1b. FT-IR and (13)C NMR results confirmed the modification of LEP-1b into SeLEP-1b...
February 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28212790/the-echinococcoses-diagnosis-clinical-management-and-burden-of-disease
#18
P Kern, A Menezes da Silva, O Akhan, B Müllhaupt, K A Vizcaychipi, C Budke, D A Vuitton
The echinococcoses are chronic, parasitic diseases that are acquired after ingestion of infective taeniid tapeworm eggs from certain species of the genus Echinococcus. Cystic echinococcosis (CE) occurs worldwide, whereas, alveolar echinococcosis (AE) is restricted to the northern hemisphere, and neotropical echinococcosis (NE) has only been identified in Central and South America. Clinical manifestations and disease courses vary profoundly for the different species of Echinococcus. CE presents as small to large cysts, and has commonly been referred to as 'hydatid disease', or 'hydatidosis'...
2017: Advances in Parasitology
https://www.readbyqxmd.com/read/28212686/validity-of-a-simplified-screening-instrument-for-assessing-overweight-children-in-a-dental-setting-a-cross-sectional-study
#19
Amir Azarpazhooh, Anoushe Sekhavat, Michael J Sigal
BACKGROUND: Obesity, with its rising prevalence among Canadians and its estimated cost of $2 billion annually in Canada, is no longer considered a cosmetic issue, but a major health issue that imposes a great burden on the healthcare system and economy. This cross sectional study aims to evaluate the feasibility of identifying the weight status of 6 to 11 year-old children in a university dental clinic using a simplified overweight screening instrument. METHODS: One hundred sixty eight healthy children were enrolled...
February 17, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28212668/association-of-community-sanitation-usage-with-soil-transmitted-helminth-infections-among-school-aged-children-in-amhara-region-ethiopia
#20
William E Oswald, Aisha E P Stewart, Michael R Kramer, Tekola Endeshaw, Mulat Zerihun, Berhanu Melak, Eshetu Sata, Demelash Gessese, Tesfaye Teferi, Zerihun Tadesse, Birhan Guadie, Jonathan D King, Paul M Emerson, Elizabeth K Callahan, Matthew C Freeman, W Dana Flanders, Thomas F Clasen, Christine L Moe
BACKGROUND: Globally, in 2010, approximately 1.5 billion people were infected with at least one species of soil-transmitted helminth (STH), Ascaris lumbricoides, Trichuris trichiura, hookworm (Ancylostoma duodenale and Necator americanus). Infection occurs through ingestion or contact (hookworm) with eggs or larvae in the environment from fecal contamination. To control these infections, the World Health Organization recommends periodic mass treatment of at-risk populations with deworming drugs...
February 17, 2017: Parasites & Vectors
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