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vitamin k2

Naoko Tsugawa
Active vitamin D3(calcitriol)and its derivatives(alfacalcidol, eldecalcitol), and vitamin K2(menatetrenone)are used as the therapeutic medicines for osteoporosis in Japan. Active vitamin D3 and its derivatives have their own feature of pharmacokinetics, due to differences in binding affinity for carrier protein such as vitamin D binding protein and in metabolism. Menatetrenone is easily absorbed from intestine, and distribute to bone higher than other natural vitamin K homologues.
2016: Clinical Calcium
Maria Fusaro, Maurizio Gallieni, Maria Antonietta Rizzo, Andrea Stucchi, Pierre Delanaye, Etienne Cavalier, Rosa M A Moysés, Vanda Jorgetti, Giorgio Iervasi, Sandro Giannini, Fabrizio Fabris, Andrea Aghi, Stefania Sella, Francesco Galli, Valentina Viola, Mario Plebani
Vitamin K (phylloquinone or vitamin K1 and menaquinones or vitamin K2) plays an important role as a cofactor in the synthesis of hepatic blood coagulation proteins, but recently has also aroused an increasing interest for its action in extra-hepatic tissues, in particular in the regulation of bone and vascular metabolism. The accurate measurement of vitamin K status in humans is still a critical issue. Along with indirect assays, such as the undercarboxylated fractions of vitamin K-dependent proteins [prothrombin, osteocalcin (OC), and matrix gla protein], the direct analysis of blood levels of phylloquinone and menaquinones forms might be considered a more informative and direct method for assessing vitamin K status...
October 12, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Aditya Shetty, Subramanyam Dasari, Souresh Banerjee, Taher Gheewala, Guoxing Zheng, Aoshuang Chen, Andre Kajdacsy-Balla, Maarten C Bosland, Gnanasekar Munirathinam
Hepatoma-derived growth factor (HDGF) is a heparin-binding growth factor, which has previously been shown to be expressed in a variety of cancers. HDGF overexpression has also previously been correlated with a poor prognosis in several cancers. The significance of HDGF in prostate cancer, however, has not been investigated. Here, we show that HDGF is overexpressed in both androgen-sensitive LNCaP cells and androgen-insensitive DU145, 22RV1, and PC-3 cells. Forced overexpression enhanced cell viability of RWPE-1 cells, whereas HDGF knockdown reduced cell proliferation in human prostate cancer cells...
September 27, 2016: Urologic Oncology
David K Cundiff, Paul S Agutter
BACKGROUND: Nutrition researchers recently recognized that deficiency of vitamin K2 (menaquinone: MK-4-MK-13) is widespread and contributes to cardiovascular disease (CVD). The deficiency of vitamin K2 or vitamin K inhibition with warfarin leads to calcium deposition in the arterial blood vessels. METHODS: Using publicly available sources, we collected food commodity availability data and derived nutrient profiles including vitamin K2 for people from 168 countries...
August 24, 2016: Curēus
Sofie Hertz Ronn, Torben Harsløf, Steen Bønløkke Pedersen, Bente Langdahl
OBJECTIVE: Clinical studies suggest that vitamin K2 protects against bone loss and fractures, however, the effect on bone quality has never been investigated. We investigated the effect of vitamin MK-7 on undercarboxylated osteocalcin (ucOC), bone mass and quality. DESIGN: We conducted a randomized, placebo-controlled, double-blinded clinical trial. METHODS: We investigated the effect of MK-7 375 µg for 12 months on bone mineral density (BMD) measured by dual x-ray absorptiometry (DXA), bone microarchitecture measured by high resolution peripheral quantitative computed tomography (HRpQCT) and biochemical bone turnover markers in 148 postmenopausal women with osteopenia...
September 13, 2016: European Journal of Endocrinology
Fengsen Duan, Yuejin Yu, Rijian Guan, Zhiliang Xu, Huageng Liang, Ling Hong
The effects of vitamin K2 on apoptosis in a variety of cancer cells have been well established in previous studies. However, the apoptotic effect of vitamin K2 on bladder cancer cells has not been evaluated. The aim of this study is to examine the apoptotic activity of Vitamin K2 in bladder cancer cells and investigate the underlying mechanism. In this study, Vitamin K2 induced apoptosis in bladder cancer cells through mitochondria pathway including loss of mitochondria membrane potential, cytochrome C release and caspase-3 cascade...
2016: PloS One
Yan-Xia Yu, Yi-Pei Li, Feng Gao, Qing-Song Hu, Yan Zhang, Dong Chen, Guang-Hui Wang
AIM: Increasing evidence has shown that environmental factors such as rotenone and paraquat induce neuroinflammation, which contributes to the pathogenesis of Parkinson's disease (PD). In this study, we investigated the molecular mechanisms underlying the repression by menaquinone-4 (MK-4), a subtype of vitamin K2, of rotenone-induced microglial activation in vitro. METHODS: A microglial cell line (BV2) was exposed to rotenone (1 μmol/L) with or without MK-4 treatment...
September 2016: Acta Pharmacologica Sinica
Linda E T Vissers, Geertje W Dalmeijer, Jolanda M A Boer, W M Monique Verschuren, Yvonne T van der Schouw, Joline W J Beulens
BACKGROUND AND AIMS: A high dietary intake of vitamin K1 (phylloquinone) and vitamin K2 (menaquinones) is thought to decrease cardiovascular disease risk by reducing vascular calcification. The objective of this study is to explore if there is a relationship between phylloquinone and menaquinones intake and risk of PAD. METHODS: We investigated the association between intake of phylloquinone and menaquinones with PAD in a prospective cohort with 36,629 participants...
September 2016: Atherosclerosis
Zhi Zhou, Ikuko Yano, Sumiko Odaka, Yosuke Morita, Satoshi Shizuta, Mamoru Hayano, Takeshi Kimura, Akinori Akaike, Ken-Ichi Inui, Kazuo Matsubara
BACKGROUND: Catheter ablation is a non-medication therapy for atrial fibrillation, and during the procedure, warfarin is withdrawn in the preoperative period to prevent the risk of bleeding. In case of emergency, vitamin K2 can be intravenously administered to antagonize the anticoagulant activity of warfarin. The aims of this study were to conduct population pharmacokinetic/pharmacodynamic modeling for retrospective clinical data and to investigate the effect of vitamin K2 on the anticoagulant activity of warfarin in the perioperative period of catheter ablation...
2016: Journal of Pharmaceutical Health Care and Sciences
Shiro Tanaka, Teruhiko Miyazaki, Yukari Uemura, Nobuaki Miyakawa, Itsuo Gorai, Toshitaka Nakamura, Masao Fukunaga, Yasuo Ohashi, Hiroaki Ohta, Satoshi Mori, Hiroshi Hagino, Takayuki Hosoi, Toshitsugu Sugimoto, Eiji Itoi, Hajime Orimo, Masataka Shiraki
The aim of this study was to investigate the efficacy of concurrent treatment with vitamin K2 and risedronate compared with treatment with risedronate alone in patients with osteoporosis and to explore subsets of patients for which concurrent treatment is particularly efficacious. Women with osteoporosis aged 65 years or older were recruited from 123 institutes in Japan and allocated to take either vitamin K2 (45 mg/day) and risedronate (2.5 mg/day or 17.5 mg/week) or risedronate (2.5 mg/day or 17.5 mg/week) alone...
August 2, 2016: Journal of Bone and Mineral Metabolism
Kotaro Shikano, Kaichi Kaneko, Mai Kawazoe, Makoto Kaburaki, Tomoko Hasunuma, Shinichi Kawai
Objective Vitamin K2 (menatetrenone) is an effective treatment for patients with postmenopausal osteoporosis. We herein performed a subanalysis of patients with systemic autoimmune diseases undergoing glucocorticoid therapy in our previous prospective study. Methods Sixty patients were categorized into a group with vitamin K2 treatment (n=20, Group A) and a group without vitamin K2 treatment (n=40, Group B). All patients were treated with bisphosphonates. Results Serum levels of osteocalcin and undercarboxylated osteocalcin decreased significantly after the start of glucocorticoid therapy in both groups, while the serum osteocalcin level was significantly higher in Group A than Group B during the third (p=0...
2016: Internal Medicine
Addepalli Pavani, Shaik Mohammad Naushad, Ganapathy Lakshmitha, Sriraman Nivetha, Balraj Alex Stanley, Amaresh Rao Malempati, Vijay Kumar Kutala
AIM: To investigate the influence of alterations in vitamin K (K1, K2 and K3) in modulating warfarin dose requirement. PATIENTS & METHODS: Reverse phase HPLC to determine the plasma vitamin K; PCR-RFLP to detect polymorphisms; and the neuro-fuzzy model to predict warfarin dose were used. RESULTS: The developed neuro-fuzzy model showed a mean absolute error of 0.000024 mg/week. CYP2C9*2 and CYP2C9*3 mediated warfarin sensitivity was observed when vitamin K is in high and low tertiles, respectively...
August 2016: Pharmacogenomics
Julia Khéde Dourado Villa, Marisa Alves Nogueira Diaz, Virgínia Ramos Pizziolo, Hércia Stampini Duarte Martino
Osteoporosis is a public health concern associated with an increased risk of bone fractures and vascular calcification. Vitamin K presents unique benefits on these issues, although understudied. The two main forms of vitamin K are phylloquinone (vitamin K1) and menaquinone (vitamin K2). In this study, it was especially investigated the action of vitamin K2 in bones and vessels. Vitamin K2 has shown to stimulate bone formation by promoting osteoblast differentiation and carboxylation of osteocalcin, and increasing alkaline phosphatase, insulin-like growth factor-1, growth differentiation factor-15, and stanniocalcin 2 levels...
July 20, 2016: Critical Reviews in Food Science and Nutrition
Mona Møller, Ingrid M Fange Gjelstad, Ingebjørg Baksaas, Tone Grande, Inger Reidun Aukrust, Christian A Drevon
We investigated the bioavailability of a synthetic form of the vitamin K2 molecule menaquinone-7 (MK-7) in a randomised single-blinded two-way cross-over study. Healthy subjects (20 - 66 years of age) took a single 180 μg dose of synthetic MK-7 or fermentation-derived MK-7, and serum MK-7 concentrations were monitored for 72 hours to calculate AUC(0 - 72 h) and Cmax. We also compared the biological effects of placebo, fermentation-derived MK-7 (90 μg) and 3 doses of synthetic MK-7(45, 90 and 180 μg) in a randomised double-blinded parallel study...
July 4, 2016: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
Tsuyoshi Yamamoto, Hidenori Matsui, Kenzaburo Yamaji, Tetsufumi Takahashi, Anders Øverby, Masahiko Nakamura, Atsuko Matsumoto, Kenichi Nonaka, Toshiaki Sunazuka, Satoshi Ōmura, Hirofumi Nakano
We aimed to identify narrow-spectrum natural compounds that specifically inhibit an alternative menaquinone (MK; vitamin K2) biosynthetic pathway (the futalosine pathway) of Helicobacter pylori. Culture broth samples of 6183 microbes were examined using the paper disc method with different combinations of 2 of the following 3 indicator microorganisms: Bacillus halodurans C-125 and Kitasatospora setae KM-6054(T), which have only the futalosine pathway of MK biosynthesis, and Bacillus subtilis H17, which has only the canonical MK biosynthetic pathway...
September 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Gilles J Basset, Scott Latimer, Abdelhak Fatihi, Eric Soubeyrand, Anna Block
Phylloquinone is a prenylated naphthoquinone that is synthesized exclusively by plants, green algae, and some species of cyanobacteria, where it serves as a vital electron carrier in photosystem I and as an electron acceptor for the formation of protein disulfide bonds. In humans and other vertebrates, phylloquinone plays the role of a vitamin (vitamin K1) that is required for blood coagulation and bone and vascular metabolism. Phylloquinone from green leafy vegetables and vegetable oil represents the major dietary source of vitamin K for humans...
June 22, 2016: Mini Reviews in Medicinal Chemistry
Monika Tyszkowski
Nutrition plays an important role, especially key vitamins D3 and K2 which are necessary for proper dentofacial development and food consistency influence on crowding and dental arches narrowing. Changes in our dentition and facial appearance are caused by changing our diet from primitive hunter gatherer to a more modern industrialized agriculture. Nutrition and its impact on epigeneticaly- mediated mechanisms continuously shape our phenotype which impacts overall health and can reverse the path for overall health and facial bone development...
2016: International Journal of Orthodontics
Yuelei Zhang, Junhui Yin, Hao Ding, Changqing Zhang, You-Shui Gao
Glucocorticoid has been reported to decrease blood vessel number and harm the blood supply in the femoral head, which is recognized to be an important mechanism of glucocorticoid-induced osteonecrosis of the femoral head (ONFH). To prevent glucocorticoid-induced ONFH, medication that promotes both bone formation and angiogenesis would be ideal. Vitamin K2 has been revealed to play an important role in bone metabolism; however, few studies have focused on the effect of Vitamin K2 on new vascular formation. Thus, this study aimed to investigate whether Vitamin K2 promoted new blood vessel formation in the presence of glucocorticoids, both in vitro and in vivo...
2016: International Journal of Biological Sciences
Yanni Mi, Xue Xiao, Dongzheng Liu, Nana Ping, Yanbing Zhu, Bo Li, Lihui Long, Yongxiao Cao
The main vitamin K-deficient model, minidose warfarin, is different from the pathological mechanism of vitamin K deficiency, which is a shortage of vitamin K. The objective of this study was to establish a new method of vitamin K-deficient model combining a vitamin K-deficient diet with the intragastrical administration of gentamicin in rats. The clotting was assayed by an automated coagulation analyser. The plasma PIVKA-II was assayed by ELISA. The vitamin K status was detected by an HPLC-fluorescence system...
April 2016: International Journal of Experimental Pathology
Harumi Okuyama, Peter H Langsjoen, Naoki Ohara, Yoko Hashimoto, Tomohito Hamazaki, Satoshi Yoshida, Tetsuyuki Kobayashi, Alena M Langsjoen
BACKGROUND: Positive associations have been observed between cardiovascular disease (CVD) and type 2 diabetes mellitus (DM), but their causal relationship has not been clarified. Nevertheless, guidelines from relevant medical societies recommend using cholesterol lowering medication (statin) for both types of patients. Medicines with several different action mechanisms have been developed, and the effectiveness of different lifestyle modifications has been studied extensively for the prevention of DM, which was successful in improving clinical marker status in relatively short-term treatments, but none have been shown to be effective in improving long-term outcomes (mortality from CVD and all causes)...
2016: Pharmacology
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