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Embryo implantation failure

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https://www.readbyqxmd.com/read/29327111/the-role-of-the-endometrial-receptivity-array-era-in-patients-who-have-failed-euploid-embryo-transfers
#1
J Tan, A Kan, J Hitkari, B Taylor, N Tallon, G Warraich, A Yuzpe, G Nakhuda
PURPOSE: Endometrial receptivity issues represent a potential source of implantation failure. The aim of this study was to document our experience with the endometrial receptivity array (ERA) among patients with a history of euploid blastocyst implantation failure. We investigated whether the contribution of the endometrial factor could be identified with the ERA test and if actionable results can lead to improved outcomes. METHODS: A retrospective review was performed for 88 patients who underwent ERA testing between 2014 and 2017...
January 11, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29308624/the-effects-of-in-vitro-maturation-technique-on-the-expression-of-genes-involved-in-embryonic-genome-activation-of-human-embryos
#2
Parvin Dorfeshan, Marefat Ghaffari Novin, Mohammad Salehi, Reza Masteri Farahani, Fatemeh Fadaei-Fathabadi, Ronak Sehatti
OBJECTIVES: In vitro maturation technique (IVM) is shown to have an effect on full maturation of immature oocytes and the subsequent embryo development. Embryonic genome activation (EGA) is considered as a crucial and the first process after fertilization. EGA failure leads to embryo arrest and possible implantation failure. This study aimed to determine the role of IVM in EGA-related genes expression in human embryo originated from immature oocytes and recovered from women receiving gonadotrophin treatment for assisted reproduction...
April 2018: Cell Journal
https://www.readbyqxmd.com/read/29306096/embryotoxic-cytokines-potential-roles-in-embryo-loss-and-fetal-programming
#3
REVIEW
Sarah A Robertson, Peck-Yin Chin, Joseph G Femia, Hannah M Brown
Cytokines in the reproductive tract environment at conception mediate a dialogue between the embryo and maternal tissues to profoundly influence embryo development and implantation success. Through effects on gene expression and the cell stress response, cytokines elicit an epigenetic impact with consequences for placental development and fetal growth, which in turn affect metabolic phenotype and long-term health of offspring. There is substantial evidence demonstrating that pro-survival cytokines, such as GM-CSF, CSF1, LIF, HB-EGF and IGFII, support embryos to develop optimally...
December 27, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29288552/effects-of-intrauterine-perfusion-of-human-chorionic-gonadotropin-in-women-with-different-implantation-failure-numbers
#4
Pinxiu Huang, Lihong Wei, Xinlin Li, Aiping Qin
PROBLEM: The aim of this research was to investigate the effects of the intrauterine perfusion of hCG before a frozen-thawed embryo transfer (FET) in women with different implantation failure numbers. METHOD OF STUDY: This was a retrospective analysis of patients undergoing FET who received an intrauterine injection hCG 1000 IU before embryo transfer. The groups included women with their first implantation failure (A group, n = 26), second implantation failure (B group, n = 122), and three or more failures (C group, n = 77)...
December 30, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29286136/proteomic-investigation-of-the-effects-of-preimplantation-factor-on-human-embryo-implantation
#5
Min Yang, Yixuan Yang, Sha She, Sanglin Li
Despite the use of adjuvant therapies, the cumulative proportion of live births remains at ~40%. Accumulating data show that low pregnancy rates, even in the presence of high fertility rates, are due to implantation failure. The present study aimed to identify and construct a profile of proteins that react with preimplantation factor (PIF) and to provide an understanding into the molecular mechanisms by which PIF promotes trophoblast invasion. Cytoplasmic proteins were immunoprecipitated with biotin‑labeled synthetic PIF or intralipid and scrambled PIF (PIFscr)...
December 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29285142/increased-levels-of-ccr7-lo-pd-1-hi-cxcr5-cd4-t-cells-and-associated-factors-bcl-6-cxcr5-il-21-and-il-6-contribute-to-repeated-implantation-failure
#6
Qiaoqiao Gong, Yuejie Zhu, Nannan Pang, Haiquan Ai, Xiaoyun Gong, Xiaolin La, Jianbing Ding
In vitro fertilization-embryo transfer (IVF-ET) can be used by infertile couples to assist with reproduction; however, failure of the embryo to implant into the endometrial lining results in failure of the IVF treatment. The present study investigated the expression of chemokine receptor 7 (CCR7)(lo) programmed death-1(PD-1)(hi) chemokine receptor type 5 (CXCR5)+ cluster of differentiation 4 (CD4)+ T cells and associated factors in patients with repeated implantation failure (RIF). A total of 30 females with RIF and 30 healthy females were enrolled in the current study...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29273681/sorcin-is-involved-during-embryo-implantation-via-activating-vegf-pi3k-akt-pathway-in-mice
#7
Kanchan Gupta, Vijay Kumar Sirohi, Suparna Kumari, Vinay Shukla, Murli Manohar, Pooja Popli, Anila Dwivedi
Earlier studies have demonstrated the cyclic variation and also the altered expression of sorcin in endometrium during early- to mid-secretory phase transition in women with unexplained infertility. The current study was undertaken to establish the functional role of sorcin in endometrial receptivity in mice. Results indicated that sorcin was highly expressed during the window of implantation in mice and functional blockage of sorcin caused significant reduction in number of implanted blastocyst. The receptivity markers (i...
December 22, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29259480/efficacy-of-the-endometrial-receptivity-array-for-repeated-implantation-failure-in-japan-a-retrospective-two-centers-study
#8
Tomoko Hashimoto, Masae Koizumi, Masakazu Doshida, Mayumi Toya, Eri Sagara, Nao Oka, Yukiko Nakajo, Nobuya Aono, Hideki Igarashi, Koichi Kyono
Aim: This study aimed to assess the efficacy of the endometrial receptivity array (ERA) as a diagnostic tool and the impact of personalized embryo transfer (pET) for the treatment of patients with recurrent implantation failure (RIF) in Japan. Methods: Fifty patients with a history of RIF with frozen-thawed blastocyst transfers were recruited from July, 2015 to April, 2016. Endometrial sampling for the ERA and histological dating and a pET according to the ERA were performed...
July 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29241924/effects-of-growth-hormone-plus-gonadotropins-on-controlled-ovarian-stimulation-in-infertile-women-of-advanced-age-poor-responders-and-previous-in%C3%A2-vitro-fertilization-failure-patients
#9
Yao-Kai Ho, Tsung-Hsien Lee, Chun-I Lee, En-Hui Cheng, Chun-Chia Huang, Lii-Shung Huang, Maw-Sheng Lee
OBJECTIVE: To investigate the effects of growth hormone (GH) cotreatment in ovarian stimulation in infertile women of advanced age, poor responders, and patients with one or more previous IVF treatment failures. MATERIALS AND METHODS: We conducted a retrospective observational study of 436 patients undergoing GH cotreatment in ovarian stimulation. The first arm included 134 infertile women of advanced age. The second arm included 236 patients with one or more IVF previous treatment failures, and the third arm included 66 younger poor responders...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29229435/developmental-and-cytogenetic-assessments-of-preimplantation-embryos-derived-from-in-vivo-or-in-vitro-matured-human-oocytes
#10
Farzaneh Fesahat, Seyed Mehdi Kalantar, Mohammad Hasan Sheikhha, Hojjatollah Saeedi, Fatemeh Montazeri, Razieh Dehghani Firouzabadi, Mohammad Ali Khalili
Aneuploidy is of great relevance to embryo selection, as it represents one of the important causes of implantation failure. Furthermore, immature oocytes, retrieved during gonadotrophin-stimulated IVF cycles, are generally discarded in clinics; whereas, there was no detectable comprehensive evidence on higher rates of aneuploidy based on maturity status on the day of oocyte retrieval. As well, the correlation between embryo morphology on aneuploidy remains unclear. The aim was to evaluate the developmental and genetic integrity of human preimplantation embryos from rescue in-vitro matured MII stage oocytes as well as in vivo matured oocytes...
December 8, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29202468/polycomb-subunit-bmi1-determines-uterine-progesterone-responsiveness-essential-for-normal-embryo-implantation
#11
Qiliang Xin, Shuangbo Kong, Junhao Yan, Jingtao Qiu, Bo He, Chan Zhou, Zhangli Ni, Haili Bao, Lin Huang, Jinhua Lu, Guoliang Xia, Xicheng Liu, Zi-Jiang Chen, Chao Wang, Haibin Wang
Natural and synthetic progestogens have been commonly used to prevent recurrent pregnancy loss in women with inadequate progesterone secretion or reduced progesterone sensitivity. However, the clinical efficacy of progesterone and its analogs for maintaining pregnancy is variable. Additionally, the underlying cause of impaired endometrial progesterone responsiveness during early pregnancy remains unknown. Here, we demonstrated that uterine-selective depletion of BMI1, a key component of the polycomb repressive complex-1 (PRC1), hampers uterine progesterone responsiveness and derails normal uterine receptivity, resulting in implantation failure in mice...
November 20, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29190151/the-effect-of-repeated-light-dark-shifts-on-uterine-receptivity-and-early-gestation-in-mice-undergoing-embryo-transfer
#12
Cathy A Goldstein, Louise M O'Brien, Ingrid L Bergin, Thomas L Saunders
Female shift workers are at increased risk for negative reproductive outcomes, and animal evidence suggests that manipulation of the light-dark cycle is detrimental to early gestation in female mice. Specifically, failure of implantation may be responsible for these findings. The objective of this study was to better delineate which reproductive processes are vulnerable to detrimental effects of maternal circadian disturbance. We exposed mice undergoing embryo transfer to repetitive phase advances of the photoperiod...
November 30, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29174158/lipids-as-regulators-of-conceptus-development-implications-for-metabolic-regulation-of-reproduction-in-dairy-cattle
#13
Eduardo S Ribeiro
Pregnancy losses are substantial in dairy cattle and threaten reproductive efficiency. A substantial proportion of these losses occur during early stages of conceptus development, including the elongation phase. Elongation of the preimplantation conceptus is a prerequisite for maternal recognition, implantation, and survival of pregnancy. The onset of elongation occurs when concentrations of lipids in endometrial epithelial cells are increased, and it requires substantial coordination of lipid metabolism by conceptus cells...
November 22, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29162091/role-of-micrornas-in-embryo-implantation
#14
REVIEW
Jingjie Liang, Shaoyu Wang, Zhengguang Wang
Failure of embryo implantation is a major limiting factor in early pregnancy and assisted reproduction. Determinants of implantation include the embryo viability, the endometrial receptivity, and embryo-maternal interactions. Multiple molecules are involved in the regulation of implantation, but their specific regulatory mechanisms remain unclear. MicroRNA (miRNA), functioning as the transcriptional regulator of gene expression, has been widely reported to be involved in embryo implantation. Recent studies reveal that miRNAs not only act inside the cells, but also can be released by cells into the extracellular environment through multiple packaging forms, facilitating intercellular communication and providing indicative information associated with physiological and pathological conditions...
November 21, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29153978/the-endometria-of-women-with-endometriosis-exhibit-dysfunctional-expression-of-complement-regulatory-proteins-during-the-mid-secretory-phase
#15
Wilder A Palomino, Chandrakant Tayade, Felipe Argandoña, Luigi Devoto, Steven L Young, Bruce A Lessey
The control of complement activation within embryo-endometrium environment is critical for embryo survival. Cell evasion from complement attack requires interaction of complement regulatory proteins (CRPs) with cell adhesion αvβ3 integrin. We aim to compare the expression of CRPs in endometria of women with and without endometriosis and to examine the molecular interaction of decay accelerating factor (DAF) with αvβ3 integrin. Endometrial expression of Membrane cofactor protein (CD46), Decay accelerating factor (DAF), Membrane attack complex inhibitory factor (CD59) and β3 integrin subunit were determined through menstrual cycle by immunohistochemistry...
October 27, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29132137/altered-circular-rna-expression-in-patients-with-repeated-implantation-failure
#16
Lin Liu, Lifei Li, Xiaoling Ma, Feng Yue, Yiqing Wang, Liyan Wang, Panpan Jin, Xuehong Zhang
BACKGROUND/AIMS: CircRNAs play an important role in regulating gene expression and the specific role of circRNAs in the pathogenesis of repeated implantation failure remains unclear. The aim of this study is to assess the differentially expressed circRNAs in patients with repeated implantation failure. METHODS: We screened circRNA expression profiles in endometrial biopsies taken from six women with repeated implantation failure and control group using circRNA microarray...
November 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29105394/melatonin-pretreated-blastocysts-along-with-calcitonin-administration-improved-implantation-by-upregulation-of-heparin-binding-epidermal-growth-factor-expression-in-murine-endometrium
#17
Fatemeh Moghani-Ghoroghi, Ghazaleh Moshkdanian, Mojtaba Sehat, Seyed Noureddin Nematollahi-Mahani, Iraj Ragerdi-Kashani, Parichehr Pasbakhsh
OBJECTIVES: Implantation failure is an obstacle in assisted reproduction techniques (ART). Calcitonin is a molecules involved in uterine receptivity and embryo implantation. Melatonin can promote embryo quality and improve implantation. This study examines the effect of pretreatment of blastocysts with melatonin and calcitonin on heparin binding-epidermal growth factor (HB-EGF) expression in murine endometrium. MATERIALS AND METHODS: In this experimental study, we collected 2-cell embryos from the oviducts of 1...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29104668/uterine-artery-blood-flow-and-microvessel-density-by-vaginal-color-doppler-ultrasonography-in-embryo-implantation-failure
#18
Zhen Li, Xingling Wang, Yichun Guan, Xiaona Yu, Jing Liu, Zhan Zhang
The purpose of this study was to investigate the clinical application of uterine artery blood flow parameters by vaginal color Doppler ultrasonography in patients with repeated embryo implantation failure and to examine the correlation between uterine artery blood flow parameters and microvessel density (MVD). We monitored the outcomes of in vitro fertilization and embryo transfer in eighty patients. We divided the patients into two groups: Pregnancy (successful pregnancy, n=50) and repeated implantation failure (more than two failures of in vitro fertilization-embryo transfer, n=30)...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29100537/extra-uterine-abdominal-full-term-foetus-in-a-15-day-pregnant-rabbit
#19
Francisco Marco-Jiménez, Ximo García-Domínguez, Jesús Valdes-Hernández, José Salvador Vicente
BACKGROUND: While ectopic pregnancies account for 1-2% of all pregnancies, abdominal pregnancy is extremely rare, accounting for approximately 1% of ectopic pregnancies. Extrauterine abdominal pregnancy is defined as the implantation and development of an embryo in the peritoneal cavity. The present report is the first of an incidental case of abdominal pregnancy within four full-term foetus simultaneously with 2 weeks of physiological gestation in a healthy doe rabbit. CASE PRESENTATION: The doe was born on November 3, 2014 and the first partum took place on May 18, 2015...
November 3, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29092905/estrogen-induces-egr1-to-fine-tune-its-actions-on-uterine-epithelium-by-controlling-pr-signaling-for-successful-embryo-implantation
#20
Hye-Ryun Kim, Yeon Sun Kim, Jung Ah Yoon, Seung Chel Yang, Mira Park, Dong-Won Seol, Sang Woo Lyu, Jin Hyun Jun, Hyunjung Jade Lim, Dong Ryul Lee, Haengseok Song
The harmonized actions of ovarian E2 and progesterone (P4) regulate the proliferation and differentiation of uterine cells in a spatiotemporal manner. Imbalances between these hormones often lead to infertility and gynecologic diseases. Whereas numerous factors that are involved in P4 signaling have been identified, few local factors that mediate E2 actions in the uterus have been revealed. Here, we demonstrate that estrogen induces the transcription factor, early growth response 1 (Egr1), to fine-tune its actions in uterine epithelial cells (ECs) that are responsible for uterine receptivity for embryo implantation...
November 1, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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