keyword
https://read.qxmd.com/read/38536816/iqgap1-and-nwasp-promote-human-cancer-cell-dissemination-and-metastasis-by-regulating-%C3%AE-1-integrin-via-fak-and-mrtf-srf
#1
JOURNAL ARTICLE
Camilla Cerutti, Serena Lucotti, Sofia T Menendez, Nicolas Reymond, Ritu Garg, Ignacio A Romero, Ruth Muschel, Anne J Ridley
Attachment of circulating tumor cells to the endothelial cells (ECs) lining blood vessels is a critical step in cancer metastatic colonization, which leads to metastatic outgrowth. Breast and prostate cancers are common malignancies in women and men, respectively. Here, we observe that β1-integrin is required for human prostate and breast cancer cell adhesion to ECs under shear-stress conditions in vitro and to lung blood vessel ECs in vivo. We identify IQGAP1 and neural Wiskott-Aldrich syndrome protein (NWASP) as regulators of β1-integrin transcription and protein expression in prostate and breast cancer cells...
March 26, 2024: Cell Reports
https://read.qxmd.com/read/38536631/the-importance-of-biomarker-testing-in-the-treatment-of-advanced-non-small-cell-lung-cancer-a-podcast
#2
JOURNAL ARTICLE
Fred R Hirsch, Chul Kim
The identification of actionable biomarkers and development of targeted therapies have revolutionized the field of lung cancer treatment. In patients with advanced non-small cell lung cancer (NSCLC), biomarker testing can inform selection of effective targeted therapies as well as avoid therapies that are less likely to be effective in certain populations. A growing number of actionable targets, including those involving EGFR, ALK, ROS1, BRAF, MET, KRAS, NTRK, RET, HER2, and PD-L1, can be identified with biomarker testing...
March 27, 2024: Oncology and Therapy
https://read.qxmd.com/read/38534755/increased-apolipoprotein-a1-expression-correlates-with-tumor-associated-neutrophils-and-t-lymphocytes-in-upper-tract-urothelial-carcinoma
#3
JOURNAL ARTICLE
Chih-Chia Chang, Chia-Bin Chang, Chiung-Ju Chen, Chun-Liang Tung, Chi-Feng Hung, Wei-Hong Lai, Cheng-Huang Shen, Chang-Yu Tsai, Ya-Yan Lai, Ming-Yang Lee, Shu-Fen Wu, Pi-Che Chen
An increased neutrophil-to-lymphocyte ratio (NLR) is a poor prognostic biomarker in various types of cancer, because it reflects the inhibition of lymphocytes in the circulation and tumors. In urologic cancers, upper tract urothelial carcinoma (UTUC) is known for its aggressive features and lack of T cell infiltration; however, the association between neutrophils and suppressed T lymphocytes in UTUC is largely unknown. In this study, we examined the relationship between UTUC-derived factors and tumor-associated neutrophils or T lymphocytes...
March 7, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534575/disulfide-cross-linked-polymeric-redox-responsive-nanocarrier-based-on-heparin-chitosan-and-lipoic-acid-improved-drug-accumulation-increased-cytotoxicity-and-selectivity-to-leukemia-cells-by-tumor-targeting-via-aikido-principle
#4
JOURNAL ARTICLE
Igor D Zlotnikov, Alexander A Ezhov, Natalia V Dobryakova, Elena V Kudryashova
We have developed a micellar formulation of anticancer drugs based on chitosan and heparin grafted with lipoic and oleic acids that can release the cytotoxic cargo (doxorubicin) in response to external stimuli, such as increased glutathione concentration-a hallmark of cancer. Natural polysaccharides (heparin and chitosan) provide the pH sensitivity of the nanocarrier: the release of doxorubicin (Dox) is enhanced in a slightly acidic environment (tumor microenvironment). Fatty acid residues are necessary for the formation of nanoparticles (micelles) and solubilization of cytostatics in a hydrophobic core...
February 20, 2024: Gels
https://read.qxmd.com/read/38533876/lymph-node-targeting-mediated-by-albumin-hitchhiking-of-synthetic-tn-glycolipid-leads-to-robust-in-vivo-antibody-production
#5
JOURNAL ARTICLE
Keerthana Thekke Veettil, Narayanaswamy Jayaraman
Tn antigen is a tumor-associated carbohydrate antigen (TACA), which is present prominently on the tumor cell surfaces and attracts an interest in the vaccine development. In this work, we demonstrate that a synthetic Tn antigen carrying glycoconjugate forms complex with circulating albumin, delivers the antigen to lymph nodes and leads to efficient production of antibody against the antigen. Synthetic Tn antigen glycoconjugate, possessing DSPE-PEG2000 linker and lipophilic moieties, undergoes micellization in PBS buffer...
March 27, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38533676/recent-advances-in-therapeutic-engineered-extracellular-vesicles
#6
REVIEW
Chenlu Yao, Hong Zhang, Chao Wang
Extracellular vesicles (EVs) are natural particles secreted by living cells, which hold significant potential for various therapeutic applications. Native EVs have specific components and structures, allowing them to cross biological barriers, and circulate in vivo for a long time. Native EVs have also been bioengineered to enhance their therapeutic efficacy and targeting affinity. Recently, the therapeutic potential of surface-engineered EVs has been explored in the treatment of tumors, autoimmune diseases, infections and other diseases by ongoing research and clinical trials...
March 27, 2024: Nanoscale
https://read.qxmd.com/read/38532562/clinical-significance-of-postoperative-folate-receptor-positive-circulating-tumor-cells-fr%C3%A2-%C3%A2-ctcs-for-long-term-prognosis-in-patients-with-invasive-adenocarcinoma-iac-of-the-lung
#7
JOURNAL ARTICLE
Zeming Ma, Zhiwei Zhou, Shijie Wang, Hong Ji, Dachuan Zhao, Liang Wang, Jinfeng Chen
BACKGROUND: The aim of the study was to evaluate the prognostic value of postoperative folate receptor-positive circulating tumor cell (FR + CTC) detection in patients with stage I-III invasive adenocarcinoma (IAC) treated with surgery. METHODS: Patients with lung adenocarcinoma (LUAD) who underwent surgical resection in Peking University Cancer Hospital and received postoperative FR + CTC analysis from July 2016 to January 2021 were retrospectively collected...
March 26, 2024: Thoracic Cancer
https://read.qxmd.com/read/38530281/enhancing-oncolytic-virus-efficiency-with-methionine-and-n-3-aminoprolil-methacrylamide-modified-acrylamide-cationic-block-polymer
#8
JOURNAL ARTICLE
Gong Chen, Yuan Yuan, Ying Li, Qianyuan He, Zizhen Qin, Han Hu, Congcong Gao, Zushun Xu, Qi Xu, Qinglei Gao, Fei Li
Oncolytic virus ablation of tumor cells has the advantages of high tumor selectivity, strong immunogenicity, and low side effects. However, the recognition and clearance of oncolytic viruses by the immune system are the main factors limiting their anti-tumor efficiency. As a highly biosafe and highly modifiable oncolytic virus vector, acrylamide can improve the long-term circulation of oncolytic viruses. Still, it is limited in its uptake efficiency by tumor cells. Herein, we constructed an N -hydroxymethyl acrylamide- b -( N -3-aminopropyl methacrylamide)- b -DMC block copolymer (NMA- b -APMA- b -DMA, NAD) as an oncolytic virus carrier, which not only improves the long-term circulation of oncolytic viruses in the body but also shows excellent stability for loading an oncolytic virus...
March 26, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38529551/red-blood-cells-function-as-reservoirs-of-tumor-dna
#9
JOURNAL ARTICLE
Jeffrey C Thompson, Sue Li, Joshua S Jose, Jarrod Predina, Aasha Gupta, Evgeniy Eruslanov, Sunil Singhal, Steven M Albelda, Nilam S Mangalmurti
Novel screening techniques for early detection of lung cancer are urgently needed. Profiling circulating tumor cell-free DNA (ctDNA) has emerged as a promising tool for biopsy-free tumor genotyping. However, both the scarcity and short half-life of ctDNA substantially limit the sensitivity and clinical utility of ctDNA detection methodologies. Our discovery that Red Blood Cells (RBCs) sequester mitochondrial DNA opens a new avenue for detecting circulating nucleic acids, as RBCs represent an unrecognized reservoir of circulating nucleic acid...
March 26, 2024: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://read.qxmd.com/read/38529368/efficacy-of-osimertinib-and-the-role-of-sequential-liquid-biopsy-in-patients-diagnosed-with-nsclc-harboring-egfr-and-braf-mutations-at-baseline-insights-from-two-case-reports
#10
Loc Carlo Bao, Alessia Padovan, Andrea Boscolo Bragadin, Lorenzo Calvetti, Valentina Guarneri, Laura Bonanno, Stefano Indraccolo
Epidermal Growth Factor Receptor (EGFR) and B-Raf (BRAF) mutations are two of the most important drivers identified in non-small-cell lung cancer (NSCLC). This report highlights two cases of patients diagnosed with metastatic NSCLC bearing concurrent EGFR and BRAF mutations at baseline and treated with osimertinib as first-line treatment. Molecular profiling was conducted in the tissue and plasma at the time of initial diagnosis, and subsequent repeated liquid biopsy examinations were planned after 10 days, 28 days, and at the time of radiological progression in the frame of the prospective translational study REM...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38526726/single-cell-proteomics-by-barcoded-phage-displayed-screening-via-an-integrated-microfluidic-chip
#11
JOURNAL ARTICLE
Yujiao Wang, Jing Zhao, Zhenwei Jiang, Yuan Ma, Rui Zhang
Recent advancements in the profiling of proteomes at the single-cell level necessitate the development of quantitative and versatile platforms, particularly for analyzing rare cells like circulating tumor cells (CTCs). In this chapter, we present an integrated microfluidic chip that utilizes magnetic nanoparticles to capture single tumor cells with exceptional efficiency. This chip enables on-chip incubation and facilitates in situ analysis of cell-surface protein expression. By combining phage-based barcoding with next-generation sequencing technology, we successfully monitored changes in the expression of multiple surface markers induced by CTC adherence...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38526307/brain-delivery-of-biomimetic-phosphorus-dendrimer-antibody-nanocomplexes-for-enhanced-glioma-immunotherapy-via-immune-modulation-of-t-cells-and-natural-killer-cells
#12
JOURNAL ARTICLE
Yamin Peng, Mengsi Zhan, Andrii Karpus, Yu Zou, Serge Mignani, Jean-Pierre Majoral, Xiangyang Shi, Mingwu Shen
Fully mobilizing the activities of multiple immune cells is crucial to achieve the desired tumor immunotherapeutic efficacy yet still remains challenging. Herein, we report a nanomedicine formulation based on phosphorus dendrimer (termed AK128)/programmed cell death protein 1 antibody (aPD1) nanocomplexes (NCs) that are camouflaged with M1-type macrophage cell membranes (M1m) for enhanced immunotherapy of orthotopic glioma. The constructed AK128-aPD1@M1m NCs with a mean particle size of 160.3 nm possess good stability and cytocompatibility...
March 25, 2024: ACS Nano
https://read.qxmd.com/read/38525298/enumeration-and-molecular-characterization-of-circulating-tumor-cell-using-an-epithelial-cell-adhesion-molecule-vimentin-epidermal-growth-factor-receptor-joint-capture-system-in-lung-cancer
#13
JOURNAL ARTICLE
Wentan Jiang, Jingyang Wu, Xianbin Lin, Zhiyao Chen, Liangan Lin, Jiansheng Yang
BACKGROUND: Detection rate and isolation yield of circulating tumor cells (CTCs) are low in lung cancer with approaches due to CTC invasiveness and heterogeneity. In this study, on the basis of the epithelial cell adhesion molecule (EpCAM) phenotype, markers of vimentin and epidermal growth factor receptor (EGFR) phenotype were added to jointly construct a precise and efficient CTC capture system for capture of lung cancer CTCs. METHODS: A CTC capture system combined with EpCAM lipid magnetic bead (Ep-LMB)/vimentin lipid magnetic bead (Vi-LMB)/EGFR lipid magnetic bead (EG-LMB) was constructed, and its performance was tested...
2024: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/38523666/demographic-and-disease-related-factors-impact-bone-turnover-and-vitamin-d-in-children-with-hemato-oncological-diseases
#14
JOURNAL ARTICLE
Natalja Jackmann, Jan Gustafsson, Pauliina Utriainen, Per Magnusson, Arja Harila, Diana Atanasova, Carina Rinaldo, Per Frisk, Outi Mäkitie
Children with hemato-oncological diseases may have significant skeletal morbidity, not only during and after treatment but also at the time of diagnosis before cancer treatment. This study was designed to evaluate the vitamin D status and circulating bone metabolic markers and their determinants in children at the time of diagnostic evaluation for hemato-oncological disease. This cross-sectional study included 165 children (91 males, median age 6.9 yr range 0.2-17.7 yr). Of them, 76 patients were diagnosed with extracranial or intracranial solid tumors, 83 with leukemia, and 6 with bone marrow failure...
April 2024: JBMR Plus
https://read.qxmd.com/read/38523522/ras-related-protein-in-brain-4a-rab4a-is-downregulated-by-mir-496-to-inhibit-the-progression-of-gastric-cancer
#15
JOURNAL ARTICLE
Rui Su, Meng Su, Yan Lu
INTRODUCTION: Ras-related protein in brain 4A (Rab4A), as a member of the Rab family, is involved in the intracellular circulation of membrane receptors or endocytic substances and regulates the progression of multiple tumors. METHOD: From our results, the knockdown of Rab4A inhibited the proliferation, migration and invasion in AGS cells. Importantly, the surface expression of epidermal growth factor receptor (EGFR) declined significantly in Rab4A knockdown cells...
October 16, 2023: Combinatorial Chemistry & High Throughput Screening
https://read.qxmd.com/read/38521927/spontaneous-tumor-lysis-syndrome-stls-during-biopsy-for-burkitt-lymphoma-a-case-report
#16
JOURNAL ARTICLE
Sirui Pan, Qiyang Shen, Jianfeng Zhou, Tao Li
BACKGROUND: Tumor lysis syndrome (TLS) is a hematologic oncological emergency characterized by metabolic and electrolyte imbalances. On breakdown of tumor cells, enormous amounts of potassium, phosphate, and nucleic acids are released into systemic circulation. TLS mainly occurs during chemotherapy. However, there are rare incidences of spontaneous tumor lysis syndrome (STLS) prior to commencement of therapy. CASE PRESENTATION: In the case being reported, the child had just undergone a biopsy...
March 23, 2024: BMC Pediatrics
https://read.qxmd.com/read/38521374/biodegradable-zwitterionic-polymer-cloaked-defective-metal-organic-frameworks-for-ferroptosis-inducing-cancer-therapy
#17
JOURNAL ARTICLE
Minghua Zhang, Xianxian Yao, Jian Xu, Jiaying Song, Shuting Mai, Weichu Zhu, Yichen Zhang, Liangliang Zhu, Wuli Yang
Ferroptosis inhibits tumor growth by iron-dependently accumulating lipid peroxides (LPO) to a lethal extent, which can result from iron overload and glutathione peroxidase 4 (GPX4) inactivation. In this study, we developed biodegradable zwitterionic polymer-cloaked atorvastatin (ATV)-loaded ferric metal-organic frameworks (Fe-MOFs) for cancer treatment. Fe-MOFs served as nanoplatforms to co-deliver ferrous ions and ATV to cancer cells; the zwitterionic polymer membrane extended the circulation time of the nanoparticles and increased their accumulation at tumor sites...
March 21, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38520730/nanosystem-delivers-senescence-activators-and-immunomodulators-to-combat-liver-cancer
#18
JOURNAL ARTICLE
Ke Gong, Juyang Jiao, Zhihua Wu, Quan Wang, Jinghan Liao, Yi Duan, Jiangtao Lin, Jian Yu, Ying Sun, Yong Zhang, Yourong Duan
CD47 blockade has emerged as a promising immunotherapy against liver cancer. However, the optimization of its antitumor effectiveness using efficient drug delivery systems or combinations of therapeutic agents remains largely incomplete. Here, patients with liver cancer co-expressing CD47 and CDC7 (cell division cycle 7, a negative senescence-related gene) are found to have the worst prognosis. Moreover, CD47 is highly expressed, and senescence is inhibited after the development of chemoresistance, suggesting that combination therapy targeting CD47 and CDC7 to inhibit CD47 and induce senescence may be a promising strategy for liver cancer...
March 23, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38520496/the-causal-effect-of-inflammatory-proteins-and-immune-cell-populations-on-diabetic-nephropathy-evidence-from-mendelian-randomization
#19
JOURNAL ARTICLE
Yi Ren, Honggang Zhang
BACKGROUND: Diabetic nephropathy (DN) is one of the diabetic microvascular complications with complex pathophysiology, and exploring the landscape of immune dysregulation in DN is valuable for pathogenesis and disease treatment. We crystallized possible inflammatory exposures into 91 circulating inflammatory proteins and 109 blood immune cells; and assessed the causal relationship between inflammation and DN using Mendelian randomization (MR). METHODS: Based on publicly available genetic data, we explored causal associations between inflammation and DN risk by two-sample MR analysis...
March 23, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38520475/how-much-do-we-know-about-the-metastatic-process
#20
REVIEW
Carolina Rodriguez-Tirado, Maria Soledad Sosa
Cancer cells can leave their primary sites and travel through the circulation to distant sites, where they lodge as disseminated cancer cells (DCCs), even during the early and asymptomatic stages of tumor progression. In experimental models and clinical samples, DCCs can be detected in a non-proliferative state, defined as cellular dormancy. This state can persist for extended periods until DCCs reawaken, usually in response to niche-derived reactivation signals. Therefore, their clinical detection in sites like lymph nodes and bone marrow is linked to poor survival...
March 23, 2024: Clinical & Experimental Metastasis
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