Gong Chen, Yuan Yuan, Ying Li, Qianyuan He, Zizhen Qin, Han Hu, Congcong Gao, Zushun Xu, Qi Xu, Qinglei Gao, Fei Li
Oncolytic virus ablation of tumor cells has the advantages of high tumor selectivity, strong immunogenicity, and low side effects. However, the recognition and clearance of oncolytic viruses by the immune system are the main factors limiting their anti-tumor efficiency. As a highly biosafe and highly modifiable oncolytic virus vector, acrylamide can improve the long-term circulation of oncolytic viruses. Still, it is limited in its uptake efficiency by tumor cells. Herein, we constructed an N -hydroxymethyl acrylamide- b -( N -3-aminopropyl methacrylamide)- b -DMC block copolymer (NMA- b -APMA- b -DMA, NAD) as an oncolytic virus carrier, which not only improves the long-term circulation of oncolytic viruses in the body but also shows excellent stability for loading an oncolytic virus...
March 26, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine