Lorrine Bournot, Thomas Payet, Julie Marcotorchino, Manar Awada, Thaïs Rouquet, Thomas Breniere, Charlène Couturier, Julien Astier, Charlotte Halimi, Emmanuelle Reboul, Flavie Sicard, Lourdes Mounien, Julien Roux, Bruno Bariohay, Jean François Landrier
Aging and obesity are associated with a decrease in plasma 25-hydroxyvitamin D (25(OH)D) levels. In the context of a growing aging population and the rising incidence of obesity, we hypothesized that aging process, either independently or in combination with obesity, could influence vitamin D (VD) metabolism, consequently resulting in the reduced 25(OH)D plasma concentrations. C57BL/6JRJ young (6 months) and old (23 months) mice fed with control (CD) or high fat diet (HF) were compared. Plasma and adipose concentration of cholecalciferol and 25(OH)D and mRNA expression of genes coding for the main VD actors were analyzed...
February 24, 2024: BioFactors