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Adipose tissue vitamin D

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https://www.readbyqxmd.com/read/29407432/thyroid-autoimmunity-an-interplay-of-factors
#1
Stephen J Merrill, Sarah B Minucci
The literature on thyroid autoimmunity has identified many potential factors at play for the initiation and progression of autoimmune thyroid diseases. These factors include genetic susceptibility, environmental factors, some drugs, iodine and selenium, infection, molecular mimics, and immune system defects. The sheer number of feasible factors makes sorting out the necessary agents from the fellow travelers difficult. In addition, many of these factors have the capability to interact-further confusing the picture...
2018: Vitamins and Hormones
https://www.readbyqxmd.com/read/29339180/leptin-blocks-the-inhibitory-effect-of-vitamin-d-on-adipogenesis-and-cell-proliferation-in-3t3-l1-adipocytes
#2
Jessica Lopes Nobre, Patricia Cristina Lisboa, Janaine Cavalcanti Carvalho, Mariana Renovato Martins, Simone Vargas, Cristina Barja-Fidalgo, Egberto Gaspar de Moura, Elaine de Oliveira
Recently, we demonstrated high serum leptin and 25(OH)D (calcidiol) in obese animals, with high C/EBPβ and PPARγ expression in adipose tissue. Since the role of vitamin D in adipogenesis remains controversial and hyperleptinemia is found in obesity, we asked if leptin could interfere in vitamin D action on adipocytes. Here, we studied the direct effect of these two hormones upon 3T3L1 preadipocytes incubated with or without 1,25(OH)2D (100 nM, 24 h) and with leptin (10-7M, 4 h later). RT-PCR (VDR and Cyp27b1/1α-hydroxylase), western blotting (VDR, Cyp27b1/1α-hydroxylase, ObR-b, C/EBPβ, PPARγ and Bax content), a cell proliferation assay and an Annexin V-FITC binding assay were performed...
January 12, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29321608/the-effect-of-maternal-vitamin-d-deficiency-during-pregnancy-on-body-fat-and-adipogenesis-in-rat-offspring
#3
Juan Wen, Qin Hong, Xingyun Wang, Lijun Zhu, Tianqi Wu, Pengfei Xu, Ziyi Fu, Lianghui You, Xing Wang, Chenbo Ji, Xirong Guo
To evaluate the effects of maternal vitamin D deficiency on body fat and adipogenesis in offspring rats, and explore the potential mechanism, we constructed a vitamin D deficient rat model and performed metabolic activity evaluation, body fat monitoring, biochemical analysis, adipogenesis assay, methylation microarray and RNA-seq for their offspring rats. We found the weight of vitamin D deficient (VDD) offspring was gradually higher than that of control (CLT) offspring, and the difference was significant since 10 weeks old...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29205876/vitamin-d-does-not-play-a-functional-role-in-adipose-tissue-development-in-rodent-models
#4
Alexandra Schutkowski, Daniela Max, Markus Bönn, Corinna Brandsch, Sarah M Grundmann, Frank Hirche, Martin S Staege, Gabriele I Stangl
SCOPE: Several studies have proposed a role of vitamin D in adipogenesis. Here, we sought to study the impact of the vitamin D receptor (Vdr) on adipocyte size in young and old mice and the effect of maternal vitamin D deficiency on fetal adipogenesis. METHODS AND RESULTS: Histological analysis of adipose tissues showed that Vdr knockout (KO) mice had smaller adipocytes than wild-type (WT) mice. Next, we compared young and old Vdr-KO and WT mice and found no differences in adipocyte sizes between weaned Vdr-KO mice and WT mice...
December 5, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29186386/gene-expression-pattern-in-response-to-cholecalciferol-supplementation-highlights-cubilin-as-a-major-protein-of-25-oh-d-uptake-in-adipocytes-and-male-mice-white-adipose-tissue
#5
Lauriane Bonnet, Esma Karkeni, Charlène Couturier, Julien Astier, Julie Dalifard, Catherine Defoort, Ljubica Svilar, Jean-Charles Martin, Franck Tourniaire, Jean-François Landrier
It is well established that the active form of vitamin D, i.e. 1,25(OH)2D, regulates the expression of genes involved in its own metabolism and transport in the kidney, and possibly in the liver. However, little is known about the transcriptional impact of cholecalciferol supplementation on white adipose tissue (WAT) and adipocytes, which are a major site of vitamin D and 25(OH)D storage in the organism. To fill this gap, we investigated the impact of cholecalciferol supplementation in WAT via a panel of genes coding for enzymes and proteins involved in vitamin D metabolism and uptake...
November 24, 2017: Endocrinology
https://www.readbyqxmd.com/read/29180820/subcutaneous-white-adipocytes-express-a-light-sensitive-signaling-pathway-mediated-via-a-melanopsin-trpc-channel-axis
#6
Katarina Ondrusova, Mohammad Fatehi, Amy Barr, Zofia Czarnecka, Wentong Long, Kunimasa Suzuki, Scott Campbell, Koenraad Philippaert, Matthew Hubert, Edward Tredget, Peter Kwan, Nicolas Touret, Martin Wabitsch, Kevin Y Lee, Peter E Light
Subcutaneous white adipose tissue (scWAT) is the major fat depot in humans and is a central player in regulating whole body metabolism. Skin exposure to UV wavelengths from sunlight is required for Vitamin D synthesis and pigmentation, although it is plausible that longer visible wavelengths that penetrate the skin may regulate scWAT function. In this regard, we discovered a novel blue light-sensitive current in human scWAT that is mediated by melanopsin coupled to transient receptor potential canonical cation channels...
November 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29136033/sun-exposure-in-pigs-increases-the-vitamin-d-nutritional-quality-of-pork
#7
D Enette Larson-Meyer, Bennett C Ingold, Samanta R Fensterseifer, Kathleen J Austin, Perry J Wechsler, Bruce W Hollis, Andrew J Makowski, Brenda M Alexander
There is a high prevalence of vitamin D insufficiency and deficiency worldwide likely because of both limited sun-exposure and inadequate dietary intake. Meat, including pork, is not typically considered a dietary source of vitamin D, possibly because of management practices that raise pigs in confinement. This experiment determined the vitamin D content of loin and subcutaneous adipose tissue in sun-exposed finisher pigs. Two separate groups of pigs were used. The first group (28 white Landrace-Duroc) was assigned at random to either sunlight exposure (SUN) in spring and summer or confinement per standard practice (Control)...
2017: PloS One
https://www.readbyqxmd.com/read/29117613/evaluation-of-the-relation-between-omentin-1-and-vitamin-d-in-postmenopausal-women-with-or-without-osteoporosis
#8
O Dikker, S Bekpinar, Gul Ozdemirler, Mujdat Uysal, Muberra Vardar, Sevgi Atar, Murat Usta, Berrin Huner
Introduction Crosstalk between bone and adipose tissues is implicated in several pathologic conditions related to bone metabolism. Omentin-1, a 34-kD protein, is released from omental adipose tissue. A few studies indicated the effect of omentin-1 on bone health and bone mineral density (BMD) and the interaction of omentin-1 with vitamin D. Therefore, this study aimed to investigate the relationship between omentin-1, vitamin D, and BMD in postmenopausal women with osteoporosis compared with non-osteoporotic counterparts...
November 8, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29112142/igfbp-3-interacts-with-the-vitamin-d-receptor-in-insulin-signaling-associated-with-obesity-in-visceral-adipose-tissue
#9
Inmaculada Moreno-Santos, Daniel Castellano-Castillo, María Fernanda Lara, Jose Carlos Fernandez-Garcia, Francisco Jose Tinahones, Manuel Macias-Gonzalez
Adipose tissue has traditionally only been considered as an energy storage organ. Nevertheless, the importance of this tissue in systemic physiology and, especially, in systemic inflammation has been highlighted in recent years. Adipose tissue expresses proteins related to vitamin D (VD) metabolism, and it has been proposed that it can act as a VD storage tissue. The active form of VD, 1,25-dihydroxyvitamin D3 (1,25(OH)₂D₃), is able to modify adipocyte and adipose tissue physiology via the VD receptor (VDR), decreasing the expression of pro-inflammatory cytokines in adipose tissue...
November 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29074956/involvement-of-the-vitamin-d-receptor-in-energy-metabolism-revealed-by-profiling-of-lysine-succinylome-of-white-adipose-tissue
#10
Han Su, Yan Lou, Yu Fu, Yalin Zhang, Ning Liu, Zuwang Liu, Yanyan Zhou, Juan Kong
Lysine succinylation, emerging as a novel post-translational modification, is closely related to the regulation of diverse biological processes, including many aspects of metabolism. Growing evidence suggests that low vitamin D status might exert an adverse impact on energy balance, adipogenesis and inflammation in white adipose tissue (WAT). However, whether there are any interactions between vitamin D and lysine succinylation still remains unknown. Here, combining high-affinity enrichment of lysine succinylated peptides with mass spectrometry and bioinformatics analysis, we reported the systematic profiling of the lysine succinylome, identifying 209 sites occurring on 159 proteins were up-regulated, 3 sites in 3 proteins were down-regulated in vitamin D receptor (VDR)-/- mice...
October 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29071664/the-relationship-between-plasma-interleukin-15-levels-and-sarcopenia-in-outpatient-older-people
#11
Ahmet Yalcin, Kamile Silay, Ahmet Rifat Balik, Gamze Avcioğlu, Almila Senat Aydin
BACKGROUND AND AIM: Sarcopenia is a geriatric syndrome in which there is a decrease in muscle mass, muscle strength, and muscle function. Interleukin-15 (IL-15), a myokine released by skeletal muscle, has effects on both muscle and adipose tissue. We evaluated the relationship between plasma IL-15 level and sarcopenia. METHODS: We evaluated a total of 160 outpatient older people, and 80 of whom had sarcopenia. Sarcopenia was defined according to the European Working Group on Sarcopenia in Older People criteria...
October 25, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28973683/vitamin-d-stored-in-fat-tissue-during-a-5-year-intervention-affects-serum-25-hydroxyvitamin-d-levels-the-following-year
#12
RANDOMIZED CONTROLLED TRIAL
Ieva Martinaityte, Elena Kamycheva, Allan Didriksen, Jette Jakobsen, Rolf Jorde
Context: Vitamin D and 25-hydroxyvitamin D [25(OH)D] are stored in adipose tissue, but the clinical relevance is uncertain. Objective: To evaluate changes in serum 25(OH)D and adipose tissue vitamin D levels after stopping vitamin D supplementation. Design: A prospective, double-blind cohort follow-up study. Setting: Clinical Research Unit at University Hospital of North Norway. Patients: Seventy-six subjects were included after participation in a 3- to 5-year prevention of type 2 diabetes study and were administered 20,000 IU of vitamin D or placebo per week...
October 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28922293/the-role-of-vitamin-d-in-cancer-cachexia
#13
Fabio Penna, Andrea Camperi, Maurizio Muscaritoli, Nicoletta Filigheddu, Paola Costelli
PURPOSE OF REVIEW: The possibility to use vitamin D supplementation to improve muscle wasting, with particular focus on cancer cachexia, is discussed. RECENT FINDINGS: Vitamin D exerts biological actions on myogenic precursor proliferation and differentiation, impinging on muscle regeneration. However, the effects of VitD supplementation in diseases associated with muscle atrophy, such as cancer cachexia, are poorly investigated. Data obtained in experimental models of cancer cachexia show that the administration of vitamin D to tumor-bearing animals is not able to prevent or delay both muscle wasting and adipose tissue depletion, despite increased expression of muscle vitamin D receptor...
December 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28884881/effects-of-a-randomized-weight-loss-intervention-trial-in-obese-adolescents-on-tibia-and-radius-bone-geometry-and-volumetric-density
#14
Jennifer C Kelley, Nicolas Stettler-Davis, Mary B Leonard, Douglas Hill, Brian H Wrotniak, Justine Shults, Virginia A Stallings, Robert Berkowitz, Melissa S Xanthopoulos, Elizabeth Prout-Parks, Sarah B Klieger, Babette S Zemel
Obese adolescents have increased fracture risk, but effects of alterations in adiposity on bone accrual and strength in obese adolescents are not understood. We evaluated 12-month changes in trabecular and cortical volumetric bone mineral density (vBMD) and cortical geometry in obese adolescents undergoing a randomized weight management program, and investigated the effect of body composition changes on bone outcomes. Peripheral quantitative CT of the radius and tibia, and whole body DXA scans were obtained at baseline, six and 12 months in 91 obese adolescents randomized to standard care versus behavioral intervention for weight loss...
September 8, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28877159/association-between-25-hydroxyvitamin-d-and-epicardial-adipose-tissue-in-chinese-non-obese-patients-with-type-2-diabetes
#15
Xiong Chen, Wenjun Wu, Luyin Wang, Yujuan Shi, Feixia Shen, Xuemei Gu, Zhijun Jia
BACKGROUND Epicardial adipose tissue (EAT) is recognized as a useful indicator for type 2 diabetes mellitus (T2DM) and obesity. However, studies on the association between vitamin D status and EAT thickness in type 2 diabetes (T2D) are limited. In this study, we aimed to evaluate the association of vitamin D (Calcifediol) status and EAT thickness (EATT) in Chinese non-obese patients with T2D. MATERIAL AND METHODS A cross-sectional study was performed among 167 non-obese T2D Chinese patients and 82 non-diabetic patients, who are age- and gender-matched during the winter months...
September 6, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28836077/circulating-il-8-levels-are-increased-in-patients-with-type-2-diabetes-and-associated-with-worse-inflammatory-and-cardiometabolic-profile
#16
F A Cimini, I Barchetta, A Porzia, F Mainiero, C Costantino, L Bertoccini, V Ceccarelli, S Morini, M G Baroni, A Lenzi, M G Cavallo
AIMS: Interleukin-8 (IL-8) is a chemokine involved in systemic immunity, macrophages infiltration and activation in adipose tissue and may play a significant role in the pathogenesis of type 2 diabetes (T2D) and atherosclerosis. Aims of this study were to evaluate circulating IL-8 levels in adult patients with T2D in comparison with non-diabetic subjects and to describe clinical and biochemical correlates of IL-8 concentration. METHODS: For this cross-sectional study, we enrolled 79 consecutive T2D individuals referring to our diabetes outpatient clinics at Sapienza University of Rome, and 37 sex, age and BMI comparable non-diabetic subjects as a control group...
October 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28719363/vitamin-d-metabolism-in-human-adipose-tissue-could-it-explain-low-vitamin-d-status-in-obesity
#17
Adryana Cordeiro, Alejandro Santos, Miguel Bernardes, Andrea Ramalho, Maria João Martins
Obesity and a low vitamin D (VD) status, as well as a positive association between them, are prevalent worldwide. Additionally, a low VD status has been positively correlated with metabolic dysfunction (although not so convincingly as for obesity). The VD receptor (VDR) mediates VD biological actions in adipose tissue (AT), where VD can be activated or inactivated/degraded through specific hydroxylation steps. Additionally, AT can also store and release VD when needed. A lower VD activation/VD inactivation ratio and an impaired VDR signaling in AT could contribute to metabolic dysfunction besides the aforementioned association between obesity and VD status...
July 18, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28696084/can-vitamin-d-deficiency-influence-muscle-performance-in-post-menopausal-women-a-multicenter-retrospective-study
#18
Giovanni Iolascon, Giulia Letizia Mauro, Pietro Fiore, Carlo Cisari, Maria Grazia Benedetti, Lorenzo Panella, Alessandro DE Sire, Dario Calafiore, Antimo Moretti, Francesca Gimigliano
BACKGROUND: The presence of the vitamin D receptor (VDR) has been recently demonstrated in human muscle supporting the theory of a role of vitamin D in the proliferation and differentiation of muscle cells. So far only few studies investigated the association between vitamin D and muscle performance in post-menopausal women. AIM: To define the functional impact of vitamin D deficiency. DESIGN: Multicenter retrospective study. SETTING: Five Italian outpatient services of Physical and Rehabilitation Medicine (PRM)...
July 10, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28676524/in-utero-vitamin-d-deficiency-predisposes-offspring-to-long-term-adverse-adipose-tissue-effects
#19
Anthony M Belenchia, Sarah A Johnson, Mark R Ellersieck, Cheryl S Rosenfeld, Catherine A Peterson
The fetal period represents an important window of susceptibility for later obesity and metabolic disease. Maternal vitamin D deficiency (VDD) during pregnancy is a global concern that may have long-lasting consequences on offspring metabolic health. We sought to determine whether a VDD in utero environment affects fetal adipose tissue development and offspring metabolic disease predisposition in adulthood. Furthermore, we sought to explore the extent to which the VDD intrauterine environment interacts with genetic background or postnatal environment to influence metabolic health...
September 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28676263/slight-hypercalcemia-is-not-associated-with-positive-responses-in-the-comet-assay-in-male-rat-liver
#20
Anette Thiel, Annie Hamel, Katrien Schaefer, Renato Cardoso, Paul Beilstein
Maintenance of physiological levels of intracellular and extracellular calcium is essential for life. Increased intracellular calcium levels are involved in cell death (apoptosis and necrosis) and are associated with positive responses in the Comet assay in vitro. In addition, high calcium and vitamin D intakes were reported to induce apoptosis in adipose tissue in obese mice and to increase DNA-migration in the Comet assay. To investigate increased serum concentration of calcium as a potential confounding factor in the regulatory Comet assay in vivo, we induced mild hypercalcemia in male Wistar rats by 3-day continuous intravenous infusion of calcium gluconate and performed the Comet assay in the liver in line with regulatory guidelines...
August 2017: Mutation Research
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