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https://www.readbyqxmd.com/read/28935935/igg1-memory-b-cells-keep-the-memory-of-ige-responses
#1
Jin-Shu He, Sharrada Subramaniam, Vipin Narang, Kandhadayar Srinivasan, Sean P Saunders, Daniel Carbajo, Tsao Wen-Shan, Nur Hidayah Hamadee, Josephine Lum, Andrea Lee, Jinmiao Chen, Michael Poidinger, Francesca Zolezzi, Juan J Lafaille, Maria A Curotto de Lafaille
The unique differentiation of IgE cells suggests unconventional mechanisms of IgE memory. IgE germinal centre cells are transient, most IgE cells are plasma cells, and high affinity IgE is produced by the switching of IgG1 cells to IgE. Here we investigate the function of subsets of IgG1 memory B cells in IgE production and find that two subsets of IgG1 memory B cells, CD80(+)CD73(+) and CD80(-)CD73(-), contribute distinctively to the repertoires of high affinity pathogenic IgE and low affinity non-pathogenic IgE...
September 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28926198/serum-free-human-msc-medium-supports-consistency-in-human-but-not-in-equine-adipose-derived-multipotent-mesenchymal-stromal-cell-culture
#2
Susanna Schubert, Walter Brehm, Aline Hillmann, Janina Burk
For clinical applications of multipotent mesenchymal stromal cells (MSCs), serum-free culture is preferable to standardize cell products and prevent contamination with pathogens. In contrast to human MSCs, knowledge on serum-free culture of large animal MSCs is limited, despite its relevance for preclinical studies and development of veterinary cellular therapeutics. This study aimed to evaluate the suitability of a commercially available serum-free human MSC medium for culturing equine adipose-derived MSCs in comparison with human adipose MSCs...
September 19, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28923439/peripheral-blood-monocytes-reveal-an-activated-phenotype-in-pediatric-uveitis
#3
Karoline Walscheid, Lisa Neekamp, Arnd Heiligenhaus, Toni Weinhage, Dirk Holzinger, Carsten Heinz, Maren Kasper, Dirk Foell
OBJECTIVE: To characterize peripheral blood monocytes in uveitis associated with juvenile idiopathic arthritis (JIAU). METHODS: Peripheral blood monocytes from children with JIA (either with (n=18) or without uveitis (n=11)), idiopathic anterior uveitis (IAU; n=12) and healthy controls (n=11) were analyzed by flow cytometry. RESULTS: Percentage of CD14+CD86+ monocytes and CD86 expression on single cell level were significantly higher in all patient groups than in controls, whereas no major differences existed between patient groups...
September 15, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28919259/ontogenic-identification-and-analysis-of-mesenchymal-stromal-cell-populations-during-mouse-limb-and-long-bone-development
#4
Gretel Nusspaumer, Sumit Jaiswal, Andrea Barbero, Robert Reinhardt, Dana Ishay Ronen, Alexander Haumer, Thomas Lufkin, Ivan Martin, Rolf Zeller
Bone-derived mesenchymal stromal cells (MSCs) differentiate into multiple lineages including chondro- and osteogenic fates and function in establishing the hematopoietic compartment of the bone marrow. Here, we analyze the emergence of different MSC types during mouse limb and long bone development. In particular, PDGFRα(pos)SCA-1(pos) (PαS) cells and mouse skeletal stem cells (mSSCs) are detected within the PDGFRα(pos)CD51(pos) (PαCD51) mesenchymal progenitors, which are the most abundant progenitors in early limb buds and developing long bones until birth...
September 1, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28916770/changes-in-cd73-cd39-and-cd26-expression-on-t-lymphocytes-of-anca-associated-vasculitis-patients-suggest-impairment-in-adenosine-generation-and-turn-over
#5
Lovis Kling, Urs Benck, Annette Breedijk, Lisa Leikeim, Marianne Heitzmann, Stefan Porubsky, Bernhard K Krämer, Benito A Yard, Anna-Isabelle Kälsch
Extracellular adenosine, generated via the concerted action of CD39 and CD73, contributes to T-cell differentiation and function. Adenosine concentrations are furthermore influenced by adenosine deaminase binding protein CD26. Because aberrant T-cell phenotypes had been reported in anti-neutrophil cytoplasmic auto-antibody (ANCA)-associated vasculitis (AAV) patients, an impaired expression of these molecules on T-cells of AAV patients was hypothesized in the present study. While in AAV patients (n = 29) CD26 was increased on CD4(+) lymphocytes, CD39 and CD73 were generally reduced on patients' T-cells...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28915673/prognositic-value-of-cd73-adenosinergic-pathway-in-solid-tumor-a-meta-analysis-and-systematic-review
#6
Rong Wang, Yingying Zhang, Xia Lin, Yalin Gao, Ying Zhu
CD73 is a glycosylphosphatidylinositol (GPI) anchored cell surface protein that is encoded by NT5E gene, plays multiple roles in tumor processes. Previous studies have presented a potential value of CD73 served as a detectable biomarker for prognosis of several solid tumors, but the results were more controversially. A comprehensive meta-analysis was conducted to precisely evaluate the prognostic role of CD73 in solid tumors. The included studies were searched in PubMed, Web of Science and EBSCO from Jan 1990 to Jan 2016...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28906582/mammalian-msc-from-selected-species-features-and-applications
#7
REVIEW
Christiane Uder, Sandra Brückner, Sandra Winkler, Hans-Michael Tautenhahn, Bruno Christ
Mesenchymal stromal/stem cells (MSC) are promising candidates for cellular therapy of different diseases in humans and in animals. Following the guidelines of the International Society for Cell Therapy, human MSC may be identified by expression of a specific panel of cell surface markers (CD105+, CD73+, CD90+, CD34-, CD14-, or CD11b-, CD79- or CD19-, HLA-DR-). In addition, multiple differentiation potential into at least the osteogenic, adipogenic, and chondrogenic lineage is a main criterion for MSC definition...
September 14, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28884332/subchondral-mesenchymal-stem-cells-from-osteoarthritic-knees-display-high-osteogenic-differentiation-capacity-through-microrna-29a-regulation-of-hdac4
#8
Wei-Shiung Lian, Ren-Wen Wu, Mel S Lee, Yu-Shan Chen, Yi-Chih Sun, Shing-Long Wu, Huei-Jing Ke, Jih-Yang Ko, Feng-Sheng Wang
Subchondral bone deterioration and osteophyte formation attributable to excessive mineralization are prominent features of end-stage knee osteoarthritis (OA). The cellular events underlying subchondral integrity diminishment remained elusive. This study was undertaken to characterize subchondral mesenchymal stem cells (SMSCs) isolated from patients with end-stage knee OA who required total knee arthroplasty. The SMSCs expressed surface antigens CD29, CD44, CD73, CD90, CD105, and CD166 and lacked CD31, CD45, and MHCII expression...
September 7, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28884087/curcumin-attenuates-harmful-effects-of-arsenic-on-neural-stem-progenitor-cells
#9
Ali Jahanbazi Jahan-Abad, Parastoo Morteza-Zadeh, Sajad Sahab Negah, Ali Gorji
OBJECTIVE: Arsenic, an environmental pollutant, decreases neuronal migration as well as cellular maturation and inhibits the proliferation of neural progenitor cells. Curcumin has been described as an antioxidant and neuroprotective agent with strong therapeutic potential in some neurological disorders. Human adipose-derived stem cells (hADSCs), a source of multipotent stem cells, can self-renew and differentiate into neural cells. The aim of the present study was to investigate the preventive effect of curcumin against arsenic toxic effects on the viability, telomerase activity, and apoptosis of neural stem/progenitor cells (NSPCs) derived from hADSCs...
July 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28881538/-co-culture-with-endometrial-stromal-cells-promotes-the-differentiation-of-menstrual-blood-derived-mesenchymal-stem-cells-into-endometrial-epithelial-cells
#10
Y S Jiang, H Y Zhu, X Y Jin, C Li, J Li, Y L Zhang, S Y Zhang
Objective: To study the potential of differentiation of menstrual blood-derived mesenchymal stem cells (MenSC) into endometrial epithelial cells (EEC) in vitro. Methods: Endometrial stromal cells (ESC) and MenSC were cultured and identified by certain methods.MenSC were co-cultured with ESC, added 10 ng/ml TGF-β1, 10 ng/ml EGF, 10 ng/ml PDGF-BB and 1×10(-7) mol/L 17-β-estradiol.The expression of cytokeratin, which was marker of EEC, was tested by immunofluorescence in differentiated MenSC. Results: MenSC proliferated quickly in vitro, and showed fusiform shape and clear structure within 10 generations...
September 5, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28878331/the-immunosuppressive-effect-of-the-tick-protein-salp15-is-long-lasting-and-persists-in-a-murine-model-of-hematopoietic-transplant
#11
Julen Tomás-Cortázar, Itziar Martín-Ruiz, Diego Barriales, Miguel Ángel Pascual-Itoiz, Virginia Gutiérrez de Juan, Alfredo Caro-Maldonado, Nekane Merino, Alberto Marina, Francisco J Blanco, Juana María Flores, James D Sutherland, Rosa Barrio, Adriana Rojas, María Luz Martínez-Chantar, Arkaitz Carracedo, Carolina Simó, Virginia García-Cañas, Leticia Abecia, José Luis Lavín, Ana M Aransay, Héctor Rodríguez, Juan Anguita
Salp15, a salivary protein of Ixodes ticks, inhibits the activation of naïve CD4 T cells. Treatment with Salp15 results in the inhibition of early signaling events and the production of the autocrine growth factor, interleukin-2. The fate of the CD4 T cells activated in the presence of Salp15 or its long-term effects are, however, unknown. We now show that Salp15 binding to CD4 is persistent and induces a long-lasting immunomodulatory effect. The activity of Salp15 results in sustained diminished cross-antigenic antibody production even after interruption of the treatment with the protein...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28878242/increased-pd-l1-expression-and-il-6-secretion-characterize-human-lung-tumor-derived-perivascular-like-cells-that-promote-vascular-leakage-in-a-perfusable-microvasculature-model
#12
Colette A Bichsel, Limei Wang, Laurène Froment, Sabina Berezowska, Stefan Müller, Patrick Dorn, Thomas M Marti, Ren-Wang Peng, Thomas Geiser, Ralph A Schmid, Olivier T Guenat, Sean R R Hall
Pericytes represent important support cells surrounding microvessels found in solid organs. Emerging evidence points to their involvement in tumor progression and metastasis. Although reported to be present in the human lung, their specific presence and functional orientation within the tumor microenvironment in non-small cell lung cancer (NSCLC) has not yet been adequately studied. Using a multiparameter approach, we prospectively identified, sorted and expanded mesenchymal cells from human primary NSCLC samples based on co-expression of CD73 and CD90 while lacking hematopoietic and endothelial lineage markers (CD45, CD31, CD14 and Gly-A) and the epithelial marker EpCAM...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28871258/distinctive-surface-glycosylation-patterns-associated-with-mouse-and-human-cd4-regulatory-t-cells-and-their-suppressive-function
#13
Joana Cabral, Shirley A Hanley, Jared Q Gerlach, Neil O'Leary, Stephen Cunningham, Thomas Ritter, Rhodri Ceredig, Lokesh Joshi, Matthew D Griffin
Regulatory T-cells (Treg) are essential for maintaining immune homeostasis and tolerance. Surface glycosylation is ubiquitous on mammalian cells and regulates diverse biological processes. While it is currently well accepted that surface glycan expression influences multiple aspects of T-cell function, little is known about the relevance of glycosylation to Treg biology. This study aimed to profile the surface glycosylation characteristics of Treg in various lymphoid compartments of mouse and in human peripheral blood with comparison to non-regulatory, conventional CD4(+) T-cells (Tconv)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28855210/cd73-promotes-resistance-to-her2-erbb2-antibody-therapy
#14
Martin Turcotte, David Allard, Deepak Mittal, Yacine Bareche, Laurence Buisseret, Vinu Jose, Sandra Pommey, Vincent Delisle, Sherene Loi, Heikki Joensuu, Pirkko-Liisa Kellokumpu-Lehtinen, Christos Sotiriou, Mark J Smyth, John Stagg
Expression of the ectonucleotidase CD73 by tumor cells, stromal cells, and immune cells is associated in cancer with immune suppression. In this study, we investigated the role of CD73 on the activity of the anti-HER2/ErbB2 monoclonal antibody (mAb) trastuzumab. In a prospective randomized phase III clinical trial evaluating the activity of trastuzumab, high levels of CD73 gene expression associated significantly with poor clinical outcome. In contrast, high levels of PD-1 and PD-L1 associated with improved clinical outcome...
August 30, 2017: Cancer Research
https://www.readbyqxmd.com/read/28851291/honokiol-improved-chondrogenesis-and-suppressed-inflammation-in-human-umbilical-cord-derived-mesenchymal-stem-cells-via-blocking-nuclear-factor-%C3%AE%C2%BAb-pathway
#15
Hao Wu, Zhanhai Yin, Ling Wang, Feng Li, Yusheng Qiu
BACKGROUND: Cartilage degradation is the significant pathological process in osteoarthritis (OA). Inflammatory cytokines, such as interleukin-1β (IL-1β), activate various downstream mediators contributing to OA pathology. Recently, stem cell-based cartilage repair emerges as a potential therapeutic strategy that being widely studied, whereas, the outcome is still far from clinical application. In this study, we focused on an anti-inflammatory agent, honokiol, which is isolated from an herb, investigated the potential effects on human umbilical cord derived mesenchymal stem cells (hUC-MSCs) in IL-1β stimulation...
August 29, 2017: BMC Cell Biology
https://www.readbyqxmd.com/read/28836991/modeling-dna%C3%A2-damage-induced-pneumopathy-in-mice-insight-from-danger-signaling-cascades
#16
REVIEW
Florian Wirsdörfer, Verena Jendrossek
Radiation-induced pneumonitis and fibrosis represent severe and dose-limiting side effects in the radiotherapy of thorax-associated neoplasms leading to decreased quality of life or - as a consequence of treatment with suboptimal radiation doses - to fatal outcomes by local recurrence or metastatic disease. It is assumed that the initial radiation-induced damage to the resident cells triggers a multifaceted damage-signalling cascade in irradiated normal tissues including a multifactorial secretory program. The resulting pro-inflammatory and pro-angiogenic microenvironment triggers a cascade of events that can lead within weeks to a pronounced lung inflammation (pneumonitis) or after months to excessive deposition of extracellular matrix molecules and tissue scarring (pulmonary fibrosis)...
August 24, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28835785/inhibitors-of-cd73-may-provide-a-treatment-for-cancer-and-autoimmune-diseases
#17
EDITORIAL
Ahmed F Abdel-Magid
No abstract text is available yet for this article.
August 10, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28832580/loss-of-cd73-mediated-extracellular-adenosine-production-exacerbates-inflammation-and-abnormal-alveolar-development-in-newborn-mice-exposed-to-prolonged-hyperoxia
#18
Huiling Li, Harry Karmouty-Quintana, Ning-Yuan Chen, Tingting Mills, Jose Molina, Michael R Blackburn, Jonathan Davies
BackgroundHyperoxic lung injury is characterized by cellular damage from high oxygen concentrations that lead to an inflammatory response and it disrupts normal alveolarization in the developing newborn lung. Adenosine is a signaling molecule that is generated extracellularly by ecto-5'-nucleotidase (CD73) in response to injury. Extracellular adenosine signals through cell surface receptors and has been found to have a protective role in acute injury situations; however, chronic elevations have been associated with detrimental changes in chronic lung diseases...
August 23, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28827387/retraction-hypoxia-inducible-factor-1%C3%AE-dependent-protection-from-intestinal-ischemia-reperfusion-injury-involves-ecto-5-nucleotidase-cd73-and-the-a2b-adenosine-receptor
#19
Melanie L Hart, Iris C Gorzolla, Jens Schittenhelm, Julee H Dalton, Holger K Eltzschig
No abstract text is available yet for this article.
September 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28816507/arthroscopic-harvest-of-adipose-derived-mesenchymal-stem-cells-from-the-infrapatellar-fat-pad
#20
Jason L Dragoo, Wenteh Chang
BACKGROUND: The successful isolation of adipose-derived mesenchymal stem cells (ADSCs) from the arthroscopically harvested infrapatellar fat pad (IFP) would provide orthopaedic surgeons with an autologous solution for regenerative procedures. PURPOSE: To demonstrate the quantity and viability of the mesenchymal stem cell population arthroscopically harvested from the IFP as well as the surrounding synovium. STUDY DESIGN: Descriptive laboratory study...
August 1, 2017: American Journal of Sports Medicine
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