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https://www.readbyqxmd.com/read/28819290/progress-towards-non-invasive-diagnosis-and-follow-up-of-celiac-disease-in-children-a-prospective-multicentre-study-to-the-usefulness-of-plasma-i-fabp
#1
M P M Adriaanse, A Mubarak, R G Riedl, F J W Ten Kate, J G M C Damoiseaux, W A Buurman, R H J Houwen, A C E Vreugdenhil
This prospective study investigates whether measurement of plasma intestinal-fatty acid binding protein (I-FABP), a sensitive marker for small intestinal epithelial damage, improves non-invasive diagnosing of celiac disease (CD), and whether I-FABP levels are useful to evaluate mucosal healing in patients on a gluten-free diet (GFD). Ninety children with elevated tTG-IgA titres and HLA-DQ2/DQ8 positivity were included (study group). Duodenal biopsies were taken, except in those fulfilling the ESPGHAN criteria...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819077/-gluten-ataxia-anti-transglutaminase-6-antibody-as-a-new-biomarker
#2
Kenji Sato, Kazunori Nanri
Gluten-related disorders (GRDs) are conditions that develop in response to the common trigger of gluten ingestion and manifest as a variety of clinical symptoms. GRDs have been considered rare in Asian countries, including Japan, because of lower consumption of wheat products than in Europe and the U.S.A. and differences in genetic background. Recently, however, GRDs, such as celiac disease and gluten ataxia, have been reported in Japan, albeit sporadically and their presence is now recognized in this country...
August 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28817113/clinical-and-histologic-mimickers-of-celiac-disease
#3
REVIEW
Amrit K Kamboj, Amy S Oxentenko
Celiac disease is an autoimmune disorder of the small bowel, classically associated with diarrhea, abdominal pain, and malabsorption. The diagnosis of celiac disease is made when there are compatible clinical features, supportive serologic markers, representative histology from the small bowel, and response to a gluten-free diet. Histologic findings associated with celiac disease include intraepithelial lymphocytosis, crypt hyperplasia, villous atrophy, and a chronic inflammatory cell infiltrate in the lamina propria...
August 17, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28816347/the-silent-enemy-celiac-disease-goes-viral
#4
Alberto Reale, Marta Trevisan, Gualtiero Alvisi, Giorgio Palù
Celiac disease is a multifactorial autoimmune chronic inflammatory disorder affecting approximately one percent of the worldwide population. In such patients, ingestion of gluten proteins from cereals like wheat, barley and rye causes damage of the small intestine mucosa, with potentially severe consequences. Onset of the disease in predisposed individuals is believed to require a still not clearly identified external trigger, such as viral infections. A very recent study has begun to shed light on a possible mechanistic basis for this hypothesis, and surprisingly linked intestinal infections caused by common reoviruses to the onset of celiac disease...
August 17, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28815514/intraepithelial-lymphocyte-immunophenotype-a-useful-tool-in-the-diagnosis-of-celiac-disease
#5
Rebeca Saborido, Nazareth Martinón, Alexandra Regueiro, Vanesa Crujeiras, Pablo Eiras, Rosaura Leis
According to new ESPGHAN guidelines, gluten challenge is considered necessary when there is doubt about the initial diagnosis of celiac disease (CD). The main aim of this study was to quantify intraepithelial lymphocyte (IEL) immunophenotype on celiac patients on gluten-containing diet (GCD) compared to those on gluten-free diet (GFD). Another aim was to evaluate the clinical utility of IELs in the CD diagnosis, especially in selected patients on GFD where diagnostic uncertainty remains. IEL immunophenotype (TCRγδ and NK-like IELs) were studied by flow cytometry in 111 children with CD (81 children with CD on GCD and 30 celiac patients on GFD) and a control group (10 children)...
August 16, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28810029/celiac-disease-and-nonceliac-gluten-sensitivity-a-review
#6
Maureen M Leonard, Anna Sapone, Carlo Catassi, Alessio Fasano
Importance: The prevalence of gluten-related disorders is rising, and increasing numbers of individuals are empirically trying a gluten-free diet for a variety of signs and symptoms. This review aims to present current evidence regarding screening, diagnosis, and treatment for celiac disease and nonceliac gluten sensitivity. Observations: Celiac disease is a gluten-induced immune-mediated enteropathy characterized by a specific genetic genotype (HLA-DQ2 and HLA-DQ8 genes) and autoantibodies (antitissue transglutaminase and antiendomysial)...
August 15, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28809572/antigen-specific-gut-inflammation-and-systemic-immune-responses-induced-by-pro-longing-wheat-gluten-sensitization-in-balb-c-murine-model
#7
Vijaykrishnaraj M, Mohan Kumar Bv, Muthukumar Sp, Nawneet K Kurrey, Pichan Prabhasankar
Gluten-related diseases such as wheat allergy, celiac disease, and gluten intolerance are widespread in the globe to genetically pre-disposed individuals. The present study aims to develop wheat-gluten induced BALB/c murine model for addressing wheat-gluten related disorders by sensitizing the wheat gluten through the route of intraperitoneal and oral challenge in prolonged days. During the sensitization, the sera were collected for specific anti-gliadin antibodies response and pro-inflammatory markers quantification...
August 15, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28806297/adherence-to-a-gluten-free-diet-assessment-by-dietician-interview-and-serology
#8
Pooja Mehta, Zhaoxing Pan, Marisa Dzarnoski Riley, Edwin Liu
We aimed to 1) determine if tissue transglutaminase autoantibody (tTG) positivity was associated with dietitian-assessed adherence to a gluten-free diet in pediatric patients with celiac disease and 2) identify areas where adherence falters. We reviewed the records of children with celiac disease who had a standardized evaluation of adherence by a registered dietitian. A negative tTG value was not associated with good adherence (p = NS). Adherent and nonadherent children differed with respect to purposeful and accidental gluten exposure (p < 0...
August 11, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28796984/allergens-and-food-additives-including-potentially-harmful-ones-present-in-food-products-that-are-preferred-by-children-and-adolescents
#9
Sandra Budrewicz, Marcin Banaszczak, Jakub Piotrowski, Maja Czerwińska, Ewa Stachowska
INTRODUCTION: The proper development of a child is linked with proper nutrition, including nutritional habits which are formed from childhood. THE AIM OF THE STUDY: The aim of the study was to establish a list of the most popular food products among children and to develop a register of potentially dangerous substances on a Facebook website. MATERIALS AND METHODS: A website was created on Facebook. The participants provided lists of favorite dishes or products...
2017: Developmental Period Medicine
https://www.readbyqxmd.com/read/28792732/integrated-magneto-chemical-sensor-for-on-site-food-allergen-detection
#10
Hsing-Ying Lin, Chen-Han Huang, Jongmin Park, Divya Pathania, Cesar M Castro, Alessio Fasano, Ralph Weissleder, Hakho Lee
Adverse food reactions, including food allergies, food sensitivities, and autoimmune reaction (e.g., celiac disease) affect 5-15% of the population and remain a considerable public health problem requiring stringent food avoidance and epinephrine availability for emergency events. Avoiding problematic foods is practically difficult, given current reliance on prepared foods and out-of-home meals. In response, we developed a portable, point-of-use detection technology, termed integrated Exogenous Antigen Testing (iEAT)...
August 9, 2017: ACS Nano
https://www.readbyqxmd.com/read/28771001/abrogation-of-immunogenic-properties-of-gliadin-peptides-through-transamidation-by-microbial-transglutaminase-is-acyl-acceptor-dependent
#11
Lin Zhou, Yvonne M C Kooy-Winkelaar, Robert A Cordfunke, Irina Dragan, Allan Thompson, Jan Wouter Drijfhout, Peter A van Veelen, Hongbing Chen, Frits Koning
Wheat gluten confers superior baking quality to wheat based products but elicits a pro-inflammatory immune response in patients with celiac disease. Transamidation of gluten by microbial transglutaminase (mTG) and tissue transglutaminase (tTG) reduces the immunogenicity of gluten; however, little information is available on the minimal modification sufficient to eliminate gliadin immunogenicity nor has the effectiveness of transamidation been studied with T-cell clones from patients. Here we demonstrate that mTG can efficiently couple three different acyl-acceptor molecules, l-lysine, glycine ethyl ester, and hydroxylamine, to gliadin peptides and protein...
August 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28764003/fundamental-study-on-reactivities-of-gluten-protein-types-from-wheat-rye-and-barley-with-five-sandwich-elisa-test-kits
#12
Barbara Lexhaller, Christine Tompos, Katharina Anne Scherf
Monitoring the compliance of gluten-free foods to the regulatory threshold of 20mg/kg of gluten is essential for celiac disease patients. The different enzyme-linked immunosorbent assays (ELISAs) for gluten detection each have specific characteristics, but there are only a few systematic comparisons. This fundamental study compared the specificities and sensitivities of the R5, G12 and Skerritt monoclonal and two polyclonal antibodies to well-defined gluten protein types (GPT) isolated from wheat, rye and barley flours...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28759621/identification-of-novel-antibody-reactive-detection-sites-for-comprehensive-gluten-monitoring
#13
Niels Röckendorf, Barbara Meckelein, Katharina A Scherf, Kathrin Schalk, Peter Koehler, Andreas Frey
Certain cereals like wheat, rye or barley contain gluten, a protein mixture that can trigger celiac disease (CD). To make gluten-free diets available for affected individuals the gluten content of foodstuff must be monitored. For this purpose, antibody-based assays exist which rely on the recognition of certain linear gluten sequence motifs. Yet, not all CD-active gluten constituents and fragments formed during food processing/fermentation may be covered by those tests. In this study, we therefore assayed the coverage of reportedly CD-active gluten components by currently available detection antibodies and determined the antibody-inducing capacity of wheat gluten constituents in order to provide novel diagnostic targets for comprehensive gluten quantitation...
2017: PloS One
https://www.readbyqxmd.com/read/28758924/unusual-onset-of-celiac-disease-and-addison-s-disease-in-a-12-year-old-boy
#14
Francesco Miconi, Emanuela Savarese, Giovanni Miconi, Gabriele Cabiati, Valentina Rapaccini, Nicola Principi, Susanna Esposito
BACKGROUND: Celiac disease (CD) is an autoimmune disorder deriving from an aberrant adaptive immune response against gluten-containing grains in genetically predisposed subjects. In a number of patients, CD is associated with one or more other autoimmune diseases. Primary Addison's disease (AD) and CD may co-exist, although this association is relatively uncommon in children. In addition, it is not precisely defined whether a gluten-free diet influences the course of AD. CASE PRESENTATION: A case of CD in a 12-year-old boy presenting as acute adrenal insufficiency is described here...
July 29, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28756881/self-reported-oral-health-and-xerostomia-in-adult-patients-with-celiac-disease-versus-a-comparison-group
#15
Tom van Gils, Gerd Bouma, Hetty J Bontkes, Chris J J Mulder, Henk S Brand
OBJECTIVES: This study aimed to assess the impact of celiac disease (CD) on oral health and xerostomia. STUDY DESIGN: Members of the Dutch Celiac Society (n = 5522) were invited to complete an online questionnaire based on the Oral Health Impact Profile 14 (OHIP-14) and Xerostomia Inventory (XI). Acquaintances and partners of the CD respondents served as the comparison group. In total, data of 740 patients with CD and 270 comparison participants were evaluated...
August 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28755266/latiglutenase-improves-symptoms-in-seropositive-celiac-disease-patients-while-on-a-gluten-free-diet
#16
Jack A Syage, Joseph A Murray, Peter H R Green, Chaitan Khosla
BACKGROUND AND AIMS: Celiac disease (CD) is a widespread condition triggered by dietary gluten and treated with a lifelong gluten-free diet (GFD); however, inadvertent exposure to gluten can result in episodic symptoms. A previous trial of latiglutenase (clinicaltrials.gov; NCT01917630), an orally administered mixture of two recombinant gluten-specific proteases, was undertaken in symptomatic subjects with persistent injury. The primary endpoint for histologic improvement was not met, presumably due to a trial effect...
July 28, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28755101/a-rare-association-of-celiac-disease-and-rectal-neuroendocrine-tumor
#17
Deniz Çetin, Özgür Tanrıverdi, Havva Solak Özşeker, Burak Özşeker
Celiac disease (CD) is a chronic immune-mediated enteropathy which is triggered by dietary gluten in genetically predisposed individuals. Increased risk of all gastrointestinal cancers was found during the first year after diagnosis of CD. Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous tumor group originating from the diffuse neuroendocrine system. Today, the incidences of both GEP-NETs and CD have increased due to the increased availability of diagnostic tools and awareness. Association of GEP-NETs with CD is rarely seen...
July 28, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28753927/self-reported-non-celiac-wheat-sensitivity-in-high-school-students-demographic-and-clinical-characteristics
#18
Antonio Carroccio, Ornella Giambalvo, Francesco La Blasca, Rosario Iacobucci, Alberto D'Alcamo, Pasquale Mansueto
BACKGROUND: Non-Celiac Wheat Sensitivity (NCWS) has recently been included among the gluten-related disorders. As no biomarkers of this disease exist, its frequency has been estimated based on self-reported symptoms, but to date no data are available about self-reported NCWS in teenagers. AIM: To explore the prevalence of self-reported NCWS in a group of high school students and to study their demographic and clinical characteristics. METHODS: The study was performed between April 2015 and January 2016 in two high schools of a coastal town in the south of Sicily (Italy)...
July 19, 2017: Nutrients
https://www.readbyqxmd.com/read/28753188/the-relationship-between-child-mortality-rates-and-prevalence-of-celiac-disease
#19
Federico Biagi, Alberto Raiteri, Annalisa Schiepatti, Catherine Klersy, Gino R Corazza
OBJECTIVES: Some evidence suggests that prevalence of celiac disease in the general population is increasing over time. Since the prognosis of celiac disease was a dismal one before discovering the role of gluten, our aim was to investigate a possible relationship between children under five-mortality rates and prevalence rates of celiac disease. METHODS: Thanks to a literature review, we found 27 studies performed in 17 different countries describing the prevalence of celiac disease in schoolchildren; between 1995 and 2011, 4 studies were performed in Italy...
July 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28738753/genetic-predictors-of-celiac-disease-lactose-intolerance-and-vitamin-d-function-and-presence-of-peptide-morphins-in-urine-of-children-with-neurodevelopmental-disorders
#20
Katarina Bojović, Biljana Stanković, Nikola Kotur, Dijana Krstić-Milošević, Vladimir Gašić, Sonja Pavlović, Branka Zukić, Đurđica Ignjatović
Gastrointestinal disturbances, nutritional deficiencies, and food intolerances are frequently observed in children with neurodevelopmental disorders (NDD). To reveal possible association of celiac disease risk variants (HLA-DQ), lactose intolerance associated variant (LCT-13910C>T) as well as variant associated with vitamin D function (VDR FokI) with NDD, polymerase chain reaction-based methodology was used. Additionally, intestinal peptide permeability was estimated in NDD patients and healthy children by measuring the level of peptides in urine using high-performance liquid chromatography...
July 24, 2017: Nutritional Neuroscience
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