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Gluten, celiac

Michael D E Potter, Marjorie M Walker, Michael P Jones, Natasha A Koloski, Simon Keely, Nicholas J Talley
OBJECTIVES: Wheat avoidance in the absence of celiac disease (CD) is common but occurrence of concurrent functional gastrointestinal disorders (FGIDs) in this group is uncertain. The aims of this study were to determine the prevalence of self-reported wheat or gluten sensitivity and doctor diagnosed CD in an Australian population, define the associated gastrointestinal (GI) symptoms and FGIDs, and determine the relationship between self-reported wheat sensitivity, demographic and medical factors...
June 19, 2018: American Journal of Gastroenterology
Imran Aziz
Celiac disease affects about 1% of the population and is treated with a gluten-free diet. However, the last decade has seen a huge rise in individuals self-reporting wheat sensitivity, and consuming a gluten-free diet, despite not having a doctor-diagnosis of celiac disease. A recent flurry of observational studies from across the globe suggests that approximately 10% of the population is self-reporting wheat sensitivity. They describe a constellation of intestinal and extra-intestinal symptoms attributed to ingestion of gluten-based products...
June 19, 2018: American Journal of Gastroenterology
Michelle S Lau, Peter D Mooney, William L White, Michael A Rees, Simon H Wong, Marios Hadjivassiliou, Peter H R Green, Benjamin Lebwohl, David S Sanders
OBJECTIVES: Celiac disease (CD) is common yet under-detected. A point of care test (POCT) may improve CD detection. We aimed to assess the diagnostic performance of an IgA/IgG-deamidated gliadin peptide (DGP)-based POCT for CD detection, patient acceptability, and inter-observer variability of the POCT results. METHODS: From 2013-2017, we prospectively recruited patients referred to secondary care with gastrointestinal symptoms, anemia and/or weight loss (group 1); and patients with self-reported gluten sensitivity with unknown CD status (group 2)...
June 19, 2018: American Journal of Gastroenterology
Tibor Pasinszki, Melinda Krebsz
Celiac disease is a chronic gluten-initiated autoimmune disorder that predominantly damages the mucosa of the small intestine in genetically-susceptible individuals. It affects a large and increasing number of the world’s population. The diagnosis of this disease and monitoring the response of patients to the therapy, which is currently a life-long gluten-free diet, require the application of reliable, rapid, sensitive, selective, simple, and cost-effective analytical tools. Celiac disease biomarker detection in full blood, serum, or plasma offers a non-invasive way to do this and is well-suited to being the first step of diagnosis...
June 16, 2018: Biosensors
Prashant Singh, Ananya Arora, Tor A Strand, Daniel A Leffler, Markku Mäki, Ciaran P Kelly, Vineet Ahuja, Govind K Makharia
GOALS: To perform a systematic review and meta-analysis to estimate the overall diagnostic accuracy of point of care tests (POCTs) for diagnosing celiac disease (CD). BACKGROUND: Recently, POCTs for CD have been developed and are commercially available. Studies have reported significant variability in their sensitivity (70% to 100%) and specificity (85% to 100%). STUDY: We searched MEDLINE, EMBASE databases, and the Cochrane library through June 2017...
June 16, 2018: Journal of Clinical Gastroenterology
Rishi Bolia, Anshu Srivastava, Aditya Kapoor, Surender Kumar Yachha, Ujjal Poddar
INTRODUCTION: We assessed cardiac function (CF) in celiac disease (CD) patients and the effect of gluten-free diet (GFD) on CF. METHODS: Prospective evaluation of CF using conventional and tissue doppler echocardiography in 50 CD patients (age 4.2 ± 1.1 years) at diagnosis and after a year of GFD (group 1), 100 CD children (group 2; 47 compliant and 53 non-compliant) in follow-up and 25 healthy controls. RESULTS: Untreated CD (n = 50) children had larger left ventricle end diastolic dimension (35...
June 16, 2018: Scandinavian Journal of Gastroenterology
Donald Duerksen, Maria Ines Pinto-Sanchez, Alexandra Anca, Joyce Schnetzler, Shelley Case, Jenni Zelin, Adrianna Smallwood, Justine Turner, Elena Verdú, J Decker Butzner, Mohsin Rashid
OBJECTIVE: To describe clinical issues related to bone health in patients with celiac disease (CD) and to provide guidance on monitoring bone health in these patients. SOURCES OF INFORMATION: A PubMed search was conducted to review literature relevant to CD and bone health, including guidelines published by professional gastroenterological organizations. MAIN MESSAGE: Bone health can be negatively affected in both adults and children with CD owing to the inflammatory process and malabsorption of calcium and vitamin D...
June 2018: Canadian Family Physician Médecin de Famille Canadien
Georgina Rubal-Peace, Caroline Sepp
No abstract text is available yet for this article.
June 5, 2018: Journal of the Academy of Nutrition and Dietetics
Valma Fuchs, Kalle Kurppa, Heini Huhtala, Markku Mäki, Leila Kekkonen, Katri Kaukinen
Background: Celiac disease is challenging to recognize, predisposing to long diagnostic delay. Currently, associated factors and significance of the delay remain obscure. Objective: The objective of this article is to investigate associated sociodemographic risk factors and health consequences of diagnostic delay in celiac disease. Methods: Altogether 611 patients were surveyed at diagnosis and after one year on a gluten-free diet regarding sociodemographic variables, well-being and use of medicines and health care services...
May 2018: United European Gastroenterology Journal
Sarah Moretti, Simona Mrakic-Sposta, Leda Roncoroni, Alessandra Vezzoli, Cinzia Dellanoce, Erika Monguzzi, Federica Branchi, Francesca Ferretti, Vincenza Lombardo, Luisa Doneda, Alice Scricciolo, Luca Elli
INTRODUCTION: High levels of reactive oxygen species (ROS) and impaired antioxidant defense systems lead to oxidative stress (OxS) and tissue injury in different intestinal and extra intestinal conditions, including celiac disease (CD). The aim of the present study was to investigate the role and potential use of ROS and other biomarkers of OxS in the clinical management of CD. METHODS: We collected duodenal specimens and blood samples from naïve patients (N-CD), patients on a gluten free diet (GFD) including responders (CD-GFD) and non-responders (NRCD)...
June 8, 2018: Clinical and Translational Gastroenterology
Brian P McAllister, Emmanuelle Williams, Kofi Clarke
Celiac disease is a complex immune-mediated gluten-sensitive enteropathy with protean clinical manifestations. It is manifest in genetically predisposed individuals who ingest gluten in varying amounts. In broad terms, it is thought to affect 1% of the population in the USA. More specifically, the prevalence increases drastically from 1:133 in patients not-at-risk, to 1:56 in symptomatic patients, to 1:39 in patients with a second-degree relative with the diagnosis, and to 1:22 in patients with a first-degree relative with the diagnosis...
June 2, 2018: Clinical Reviews in Allergy & Immunology
Cristina Oana Mărginean, Lorena Elena Meliţ, Vlăduţ Stefănuţ Săsăran, Cristian Dan Mărginean, Maria Oana Mărginean
RATIONALE: Celiac disease is a chronic, immune-mediated, multiorgan disorder that affects susceptible individuals, and it is triggered by gluten and other prolamins. PATIENT CONCERNS: We present the case of a 1-year-old male child, with a history of idiopathic pericardial effusion, admitted in our clinic for severe abdominal bloating, irritability, loss of appetite and intermittent diarrheic stools. The clinical findings were: influenced general status, irritability, distended abdomen, and diffuse abdominal tenderness...
June 2018: Medicine (Baltimore)
Juan Lasa, Astrid Rausch, Luis Florez Bracho, Josefina Altamirano, Daniela Speisky, María Teresa García de Dávila, Alejandro Iotti, Ignacio Zubiaurre
Background: The association between celiac disease and colorectal neoplasia has been previously studied, but the question whether recently diagnosed celiac patients show an increased colorectal adenoma prevalence remains unanswered. Aims: To compare the prevalence of colorectal adenomas between adult patients with a recent diagnosis of celiac disease versus healthy controls. Materials and Methods: A retrospective case-control study was undertaken...
2018: Gastroenterology Research and Practice
Sarah Micozzi, Sonsoles Infante, Victoria Fuentes-Aparicio, Alberto Álvarez-Perea, Lydia Zapatero
INTRODUCTION: Celiac disease and wheat allergy (WA) are infrequent diseases in the general population, and a combination of the 2 is particularly rare. Celiac disease occurs in around 1% of the general population and WA in around 1% of all children. CASE REPORT: We report 2 patients with celiac disease and a gluten-free diet who developed WA consistent in anaphylaxis and an eyelid angioedema, respectively, through accidental wheat exposure. A serum study and an intestinal biopsy confirmed celiac disease...
May 30, 2018: International Archives of Allergy and Immunology
Rinaldo Pellicano, Marilena Durazzo
No abstract text is available yet for this article.
July 2018: European Journal of Gastroenterology & Hepatology
Julián Rodríguez Almagro, David Rodríguez Almagro, Carmen Solano Ruiz, José Siles González, Antonio Hernández Martínez
Celiac disease represents a problem in our society, not only because of its interest in terms of healthcare, but also because of its increasing prevalence in recent years and the impact it has on sufferers and their families. This integrative review investigated current knowledge about the experience of living with a gluten-free diet, as well as social support and the role played by nurses and/or associations in the process. A total of 18 articles were selected. Results revealed greater family support is needed to deal with the day-to-day issues of a gluten-free diet...
May 2018: Gastroenterology Nursing: the Official Journal of the Society of Gastroenterology Nurses and Associates
Soulef Benkadri, Ana Salvador, Mohammed N Zidoune, Teresa Sanz
A gluten-free biscuit for celiac children based on composite rice-chickpea flour was developed. Xanthan gum was used to overcome the handling difficulties associated with the absence of gluten in the rice-chickpea flour. The effect of different levels of xanthan gum incorporation (0.5, 1, and 1.5% of flour) on the texture and rheological properties of the dough and on the texture, dimensions, moisture, water activity (aw ), and sensory acceptability of the biscuit was studied. The incorporation of xanthan gum into rice-chickpea flour significantly affected the textural and linear viscoelastic properties of the dough, as well as the texture, weight, moisture, aw , and dimensions of the biscuits...
January 1, 2018: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
Luigina De Leo, Vincenzo Villanacci, Fabiana Ziberna, Serena Vatta, Stefano Martelossi, Grazia Di Leo, Chiara Zanchi, Matteo Bramuzzo, Fabiola Giudici, Alessandro Ventura, Tarcisio Not
BACKGROUND AND AIMS: Anti-tissue transglutaminase antibodies (anti-tTG) have simplified celiac disease (CD) diagnosis. However, in atypical forms of CD, intestinal biopsy is still required. This prospective study investigates whether histological analysis of the duodenal bulb combined with intestinal IgA anti-tTG deposit immunoassay makes CD diagnosis possible in at-risk children with low concentrations of serum anti-tTG. METHODS: Histological and intestinal IgA anti-tTG deposit immunoassays were used...
May 25, 2018: Gastrointestinal Endoscopy
Karin W Schilling, Karla Yohannessen, Magdalena Araya
INTRODUCTION: Celiac disease (CD) is a chronic immune-mediated enteropathy present in ~1% of population. Gluten-free diet (GFD) is the only treatment for this condition and the main limitation of its efficacy is the lack of adherence. OBJECTIVE: To assess factors influencing adherence to GFD in pediatric patients and measure the concordance between serological results and a nutritional adhe rence questionnaire. PATIENTS AND METHODS: celiac patients younger than 18 years of age, diagnosed CD following ESPGHAN criteria, on GFD for at least 6 months and consulting at Hospital Roberto del Río, Santiago, in 2008-2016, were assessed...
April 2018: Revista Chilena de Pediatría
Laura Kaplan, Leslie Castelo-Soccio
The relationship between alopecia areata and celiac disease has been suspected for more than 20 years. For a particular individual with alopecia areata, the risk of coexisting celiac disease and the potential benefit of a gluten-free diet on hair loss or regrowth is known. Despite this limited information, patients often aske dermatologists whether they should undergo celiac disease testing or begin a gluten-free diet. We reviewed all available studies of the relationship between alopecia areata and celiac disease to provide guidance to practicing clinicians...
May 25, 2018: Pediatric Dermatology
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