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https://www.readbyqxmd.com/read/29216767/prevalence-and-factors-associated-with-gluten-sensitivity-in-inflammatory-bowel-disease
#1
Berkeley N Limketkai, Rachel Sepulveda, Tressia Hing, Neha D Shah, Monica Choe, David Limsui, Shamita Shah
OBJECTIVES: Gluten sensitivity (GS) arises with celiac disease and has also been found in non-celiac disorders, although its characteristics in inflammatory bowel disease (IBD) are unclear. This study evaluated the prevalence of GS and factors associated with GS in IBD. METHODS: Adult IBD patients at a tertiary-care medical center completed a survey of their demographics, medical history, family history, social history and symptoms. Data on IBD characteristics were abstracted from the medical records...
December 7, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29216605/gluten-peptides-drive-healthy-and-celiac-monocytes-toward-an-m2-like-polarization
#2
Amelia Barilli, Federica Gaiani, Barbara Prandi, Martina Cirlini, Filippo Ingoglia, Rossana Visigalli, Bianca Maria Rotoli, Nicola de'Angelis, Stefano Sforza, Gian Luigi de'Angelis, Valeria Dall'Asta
Celiac disease (CD) is an immune-mediated enteropathy triggered by ingested gluten in genetically susceptible individuals and sustained by both adaptive and innate immune responses. Recent studies in murine macrophages demonstrated that the activation of arginase (ARG) metabolic pathway by gluten peptides contributes to the modulation of intestinal permeability in vitro. Here we characterize the effects of gluten on arginine metabolism and cell polarization in human monocytes from both healthy and CD subjects; both a simplified enzymatic digestion of gliadin and a physiological digestion of whole wheat have been tested...
November 5, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29209126/intestinal-parameters-of-oxidative-imbalance-in-celiac-adults-with-extraintestinal-manifestations
#3
Agnieszka Piatek-Guziewicz, Agata Ptak-Belowska, Magdalena Przybylska-Felus, Pawel Pasko, Pawel Zagrodzki, Tomasz Brzozowski, Tomasz Mach, Malgorzata Zwolinska-Wcislo
AIM: To evaluate selected intestinal parameters of oxidative stress, and antioxidant capacity in adult celiac disease patients with extraintestinal manifestations. METHODS: The study involved 85 adult patients divided into the following subgroups: (1) patients with newly diagnosed celiac disease (CD) (n = 7); (2) celiac patients not adhering to a gluten-free diet (GFD) (n = 22); (3) patients with CD on the GFD (n = 31); and (4) patients with functional disorders of the gastrointestinal tract, serving as controls (n = 25)...
November 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29207979/a-propeptide-toolbox-for-secretion-optimization-of-flavobacterium-meningosepticum-endopeptidase-in-lactococcus-lactis
#4
Pei Yu Lim, Lee Ling Tan, Dave Siak-Wei Ow, Fong T Wong
BACKGROUND: Lactic acid bacteria are a family of "generally regarded as safe" organisms traditionally used for food fermentation. In recent years, they have started to emerge as potential chassis for heterologous protein production. And more recently, due to their beneficial properties in the gut, they have been examined as potential candidates for mucosal delivery vectors, especially for acid-sensitive enzymes. One such application would be the delivery of gluten-digesting endopeptidases for the treatment of celiac disease...
December 5, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/29207559/tooth-wear-is-frequent-in-adult-patients-with-celiac-disease
#5
Massimo Amato, Fabiana Zingone, Mario Caggiano, Paola Iovino, Cristina Bucci, Carolina Ciacci
(1) Background: Celiac disease (CD) patients can be affected by mouth and tooth disorders, which are influenced by their gluten-free diet. The aim of our research was to evaluate the pathological conditions of the stomatognathic system observed in celiac patients on a gluten-free diet. (2) Methods: we consecutively recruited celiac patients on a gluten-free diet at our celiac center, as well as healthy volunteers. Two dentists examined all patients/controls and checked them for any mouth disorder. (3) Results: Forty-nine patients affected by celiac disease (age at test 31...
December 4, 2017: Nutrients
https://www.readbyqxmd.com/read/29204051/intestinal-epithelium-intraepithelial-lymphocytes-and-the-gut-microbiota-key-players-in-the-pathogenesis-of-celiac-disease
#6
REVIEW
Bożena Cukrowska, Agnieszka Sowińska, Joanna Beata Bierła, Elżbieta Czarnowska, Anna Rybak, Urszula Grzybowska-Chlebowczyk
Celiac disease (CD) is a chronic immune-mediated disorder triggered by the ingestion of gluten in genetically predisposed individuals. Before activating the immune system, gluten peptides are transferred by the epithelial barrier to the mucosal lamina propria, where they are deamidated by intestinal tissue transglutaminase 2. As a result, they strongly bind to human leucocyte antigens (HLAs), especially HLA-DQ2 and HLA-DQ8, expressed on antigen-presenting cells. This induces an inflammatory response, which results in small bowel enteropathy...
November 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29194702/the-role-of-tmprss6-and-hfe-variants-in-iron-deficiency-anemia-in-celiac-disease
#7
Luigia De Falco, Raffaella Tortora, Nicola Imperatore, Mariasole Bruno, Mario Capasso, Domenico Girelli, Annalisa Castagna, Nicola Caporaso, Achille Iolascon, Antonio Rispo
We investigated the role of HFE C282Y, H63D and TMPRSS6 A736V variants in the pathogenesis of iron deficiency anemia (IDA) in celiac disease (CD) patients, at diagnosis and after 1-year of gluten free diet (GFD). Demographic and clinical features were prospectively recorded for all CD patients between 2013 and 2017. C282Y, H63D and A736V variants were evaluated for CD patients and controls. Finally, 505 consecutive CD patients and 539 age-matched control subjects were enrolled. At diagnosis, 229 CD subjects had IDA (45...
December 1, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29194641/chemometric-analysis-of-minerals-in-gluten-free-products
#8
Anna Gliszczyńska-Świgło, Inga Klimczak, Iga Rybicka
BACKGROUND: Numerous studies indicate mineral deficiencies in people on a gluten-free (GF) diet. These deficiencies may indicate that GF products are less valuable source of minerals than gluten-containing products. In the study, the nutritional quality of fifty GF products is discussed taking into account the nutritional requirements for minerals expressed as % Recommended Daily Allowance (%RDA) or % Adequate Intake (%AI) for a model celiac patient. Analysed elements were: calcium, potassium, magnesium, sodium, copper, iron, manganese, and zinc...
November 30, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29191561/epitope-specific-immunotherapy-targeting-cd4-positive-t-cells-in-celiac-disease-safety-pharmacokinetics-and-effects-on-intestinal-histology-and-plasma-cytokines-with-escalating-dose-regimens-of-nexvax2-in-a-randomized-double-blind-placebo-controlled-phase-1
#9
A James M Daveson, Hooi C Ee, Jane M Andrews, Timothy King, Kaela E Goldstein, John L Dzuris, James A MacDougall, Leslie J Williams, Anita Treohan, Michael P Cooreman, Robert P Anderson
BACKGROUND: Nexvax2® is a novel, peptide-based, epitope-specific immunotherapy intended to be administered by regular injections at dose levels that increase the threshold for clinical reactivity to natural exposure to gluten and ultimately restore tolerance to gluten in patients with celiac disease. Celiac disease patients administered fixed intradermal doses of Nexvax2 become unresponsive to the HLA-DQ2·5-restricted gluten epitopes in Nexvax2, but gastrointestinal symptoms and cytokine release mimicking gluten exposure, that accompany the first dose, limit the maximum tolerated dose to 150μg...
November 22, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29181545/non-celiac-gluten-sensitivity-people-without-celiac-disease-avoiding-gluten-is-it-due-to-histamine-intolerance
#10
REVIEW
Wolfgang J Schnedl, Sonja Lackner, Dietmar Enko, Michael Schenk, Harald Mangge, Sandra J Holasek
INTRODUCTION: Food intolerance/malabsorption is caused by food ingredients, carbohydrates (mainly lactose and fructose), proteins (gluten), and biogenic amines (histamine) which cause nonspecific gastrointestinal and extra-intestinal symptoms. Here we focus on possible etiologic factors of intolerance/malabsorption especially in people with non-celiac gluten sensitivity (NCGS) or the so-called people without celiac disease avoiding gluten (PWCDAG) and histamine intolerance. METHODS: Recognizing the recently described symptoms of NCGS (PWCDAG) we review correlations and parallels to histamine intolerance (HIT)...
November 27, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29163738/a-case-of-moderate-sprue-like-enteropathy-associated-with-telmisartan
#11
Aurelio Negro, Loredana De Marco, Valentina Cesario, Rosaria Santi, Maria Chiara Boni, Magda Zanelli
Sprue-like enteropathy associated with olmesartan medoxomil use has been recently reported. Its clinical manifestations include diarrhea, weight loss and malabsorption. Duodenal biopsies show villous atrophy (VA) with or without intraepithelial lymphocytosis and inflammation of the lamina propria. Serology for celiac disease (CD) is negative and gluten-free diet does not result in clinical improvement. Symptoms resolve after olmesartan discontinuation. Follow-up biopsies show recovery/improvement of the duodenum...
December 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29162372/genetics-environment-and-asthma-associated-with-celiac-disease-in-the-extended-family-of-an-affected-child
#12
R Sigala-Robles, S V Aguayo-Patrón, A M Calderón de la Barca
INTRODUCTION: Celiac disease (CD) is an autoimmune enteropathy associated with gluten ingestion. In extended families of celiac patients that live in close proximity of one another, shared genetic and environmental factors can predispose them to CD. AIM: The aim of this study was to provide evidence about the genetic and environmental factors involved in the development of CD in the extended family of a pediatric patient. METHODS: The medical history, environmental conditions, and participant weight, height, and peripheral blood samples were evaluated...
November 18, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29160841/the-overlapping-area-of-non-celiac-gluten-sensitivity-ncgs-and-wheat-sensitive-irritable-bowel-syndrome-ibs-an-update
#13
REVIEW
Carlo Catassi, Armin Alaedini, Christian Bojarski, Bruno Bonaz, Gerd Bouma, Antonio Carroccio, Gemma Castillejo, Laura De Magistris, Walburga Dieterich, Diana Di Liberto, Luca Elli, Alessio Fasano, Marios Hadjivassiliou, Matthew Kurien, Elena Lionetti, Chris J Mulder, Kamran Rostami, Anna Sapone, Katharina Scherf, Detlef Schuppan, Nick Trott, Umberto Volta, Victor Zevallos, Yurdagül Zopf, David S Sanders
Gluten-related disorders have recently been reclassified with an emerging scientific literature supporting the concept of non-celiac gluten sensitivity (NCGS). New research has specifically addressed prevalence, immune mechanisms, the recognition of non-immunoglobulin E (non-IgE) wheat allergy and overlap of NCGS with irritable bowel syndrome (IBS)-type symptoms. This review article will provide clinicians with an update that directly impacts on the management of a subgroup of their IBS patients whose symptoms are triggered by wheat ingestion...
November 21, 2017: Nutrients
https://www.readbyqxmd.com/read/29146521/hla-dq-gluten-tetramer-blood-test-accurately-identifies-patients-with-and-without-celiac-disease-in-absence-of-gluten-consumption
#14
Vikas K Sarna, Knut E A Lundin, Lars Mørkrid, Shuo-Wang Qiao, Ludvig M Sollid, Asbjørn Christophersen
BACKGROUND & AIMS: Celiac disease is characterized by HLA-DQ2/8-restricted responses of CD4+ T cells to cereal gluten proteins. A diagnosis of celiac disease based on serologic and histologic evidence and duodenal histology requires patients to be on gluten-containing diets. The growing number of individuals adhering to a gluten-free diet (GFD) without exclusion of celiac disease complicates its detection. HLA-DQ-gluten tetramers can be used to detect gluten-specific T cells in blood of patients with celiac disease, even if they are on a GFD...
November 13, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29142524/a-case-of-celiac-disease-with-neurologic-manifestations-misdiagnosed-as-amyotrophic-lateral-sclerosis
#15
Hyoju Ham, Bo-In Lee, Hyun Jin Oh, Se Hwan Park, Jin Su Kim, Jae Myung Park, Young Seok Cho, Myung-Gyu Choi
Celiac disease (CD) is an immune-mediated enteropathy and is a rare disease in Asia, including in Korea. However, the ingestion of wheat products, which can act as a precipitating factor of CD, has increased rapidly. CD is a common cause of malabsorption, but many patients can present with various atypical manifestations as first presented symptoms, including anemia, osteopenia, infertility, and neurological symptoms. Thus, making a diagnosis is challenging. We report a case of CD that mimicked amyotrophic lateral sclerosis (ALS)...
October 2017: Intestinal Research
https://www.readbyqxmd.com/read/29142467/non-celiac-gluten-sensitivity-all-wheat-attack-is-not-celiac
#16
REVIEW
Samuel O Igbinedion, Junaid Ansari, Anush Vasikaran, Felicity N Gavins, Paul Jordan, Moheb Boktor, Jonathan S Alexander
Currently, 1% of the United States population holds a diagnosis for celiac disease (CD), however, a more recently recognized and possibly related condition, "non-celiac gluten sensitivity" (NCGS) has been suggested to affect up to 6% of the United States public. While reliable clinical tests for CD exist, diagnosing individuals affected by NCGS is still complicated by the lack of reliable biomarkers and reliance upon a broad set of intestinal and extra intestinal symptoms possibly provoked by gluten. NCGS has been proposed to exhibit an innate immune response activated by gluten and several other wheat proteins...
October 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29136587/management-of-eosinophilic-esophagitis-and-celiac-disease
#17
REVIEW
Rok Seon Choung, Jeffrey A Alexander, David A Katzka, Joseph A Murray
Eosinophilic esophagitis (EoE) and celiac disease (CeD) are chronic immune mediated gastrointestinal disorders characterized by mucosal inflammation, both of which are related to food antigens, but with differences in clinical and histopathological features. When untreated, both diseases lead to destruction of the epithelium. While a strict gluten-free diet is the only effective therapy for CeD, several therapeutic options, such as proton pump inhibitors, topical steroids and diet elimination therapy are available for EoE...
November 10, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29132967/unexplained-infertility-and-undiagnosed-celiac-disease-study-of-a-multiethnic-canadian-population
#18
Beth Gunn, Kellie E Murphy, Ellen M Greenblatt
OBJECTIVE: The aims of this study were to examine the prevalence of Celiac disease (CD) in Canadian women with unexplained infertility versus women with an identifiable cause of infertility and to assess the sensitivity of the point-of-care Biocard Celiac Test Kit versus standard serum serologic testing. METHODS: In this prospective cohort study, women aged 18 to 44 who were evaluated for infertility between February 2010 and May 2012 at a tertiary academic care fertility clinic in Toronto, ON, were invited to participate...
November 10, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29132529/celiac-disease-and-gluten-sensitivity
#19
REVIEW
Katharine C DeGeorge, Jeanetta W Frye, Kim M Stein, Lisa K Rollins, Daniel F McCarter
Celiac disease is an immune-mediated enteropathy triggered by gluten that affects genetically predisposed individuals, typically causing intestinal symptoms and malabsorption. Diagnosis requires stepwise evaluation with anti-tissue transglutaminase IgA and histologic analysis of the small bowel. Strict adherence to a gluten-free diet is the primary treatment. Patients with symptoms thought to be related to gluten but without evidence of celiac disease are difficult to diagnose and treat. Consider first advising general nutritional improvements...
December 2017: Primary Care
https://www.readbyqxmd.com/read/29131356/gluten-sensitivities-and-the-allergist-threshing-the-grain-from-the-husks
#20
REVIEW
J G Burkhardt, A Chapa-Rodriguez, S L Bahna
"Gluten sensitivity" has become commonplace among the public. Wheat allergy (WA) and celiac disease (CD) are well-defined entities, but are becoming a fraction of individuals following a gluten-free diet. WA has a prevalence of <0.5%. Wheat, specifically its omega-5 gliadin fraction, is the most common allergen implicated in food-dependent, exercise-induced anaphylaxis. CD is a non-IgE hypersensitivity to certain cereal proteins: gluten in wheat, secalin in rye, hordein in barley, and to a lesser extent avenin in oat...
November 13, 2017: Allergy
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