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https://www.readbyqxmd.com/read/29039796/development-and-validation-of-the-celiac-disease-children-s-activities-report-cd-chart-for-promoting-self-management-among-children-and-adolescents
#1
Sonya Meyer, Sara Rosenblum
Adherence to a restrictive gluten-free diet is the only known treatment for celiac disease (CD). Children and adolescents with CD encounter challenges while managing the diet in daily activities. Understanding their participation characteristics is lacking. The aim was to describe the development and validation process of the Celiac Disease-Children's Activities Report (CD-Chart). The final CD-Chart includes nine food-related activities that are measured by six core dimensions: frequency, preference, preparation, involvement, help, and self-determination...
October 17, 2017: Nutrients
https://www.readbyqxmd.com/read/29033765/celiac-disease-associated-with-a-benign-granulomatous-mass-demonstrating-self-regression-after-initiation-of-a-gluten-free-diet
#2
Abhinav Tiwari, Himani Sharma, Khola Qamar, Zubair Khan, Umar Darr, Anas Renno, Ali Nawras
Celiac disease is a chronic immune-mediated enteropathy in which dietary gluten induces an inflammatory reaction predominantly in the duodenum. Celiac disease is known to be associated with benign small bowel thickening and reactive lymphadenopathy that often regresses after the institution of a gluten-free diet. A 66-year-old male patient with celiac disease presented with abdominal pain and diarrheal illness. Computerized tomography of the abdomen revealed a duodenal mass. Endoscopic ultrasound-guided fine needle aspiration of the mass revealed bizarre stromal cells which represent a nonspecific tissue reaction to inflammation...
May 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29030981/mesalazine-treatment-in-organotypic-culture-of-celiac-patients-comparative-study-with-gluten-free-diet
#3
EDITORIAL
Benedetti E, A Viscido, V Castelli, C Maggiani, M d'Angelo, E Di Giacomo, A Antonosante, A Picarelli, G Frieri
Given the central role of gluten in the pathogenesis of celiac disease (CD), a strict gluten-free diet (GFD) is the only validated treatment able to restore epithelium integrity and eliminate risks of complications. The risk of gluten contamination and the persistence of inflammation, even in patients strictly adhering to GFD, may render this treatment not always effective claiming the necessity of different new solutions. Oxidative and nitrosative stress have been indicated to play a pathophysiological role in CD...
October 14, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29026596/flow-cytometry-of-duodenal-intraepithelial-lymphocytes-improves-diagnosis-of-celiac-disease-in-difficult-cases
#4
Julio Valle, José Mario T Morgado, Juan Ruiz-Martín, Antonio Guardiola, Miriam Lopes-Nogueras, Almudena García-Vela, Beatriz Martín-Sacristán, Laura Sánchez-Muñoz
BACKGROUND: Diagnosis of celiac disease is difficult when the combined results of serology and histology are inconclusive. Studies using flow cytometry of intraepithelial lymphocytes (IELs) have found that celiac patients have increased numbers of γδ IELs, along with a decrease in CD3-CD103 + IELs. OBJECTIVE: The objective of this article is to assess the role of flow cytometric analysis of IELs in the diagnosis of celiac disease in difficult cases. METHODS: A total of 312 patients with suspicion of celiac disease were included in the study...
October 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29026594/subtypes-of-chronic-gastritis-in-patients-with-celiac-disease-before-and-after-gluten-free-diet
#5
Dolores Gabrieli, Fabiana Ciccone, Annalisa Capannolo, Angelo Viscido, Giorgio Valerii, Donatella Serva, Stefano Necozione, Gino Coletti, Giuseppe Calvisi, Dina Melideo, Giuseppe Frieri, Giovanni Latella
BACKGROUND: Celiac disease (CD) often manifests with dyspeptic symptoms and chronic gastritis is a common finding. AIM: To evaluate the frequency of lymphocytic gastritis (LG), chronic active gastritis (CAG), and chronic inactive gastritis (CIG) in patients with CD, before and after gluten-free diet (GFD). METHODS: A five-year prospective study including all consecutive patients with a new diagnosis of CD was conducted. Gastric and duodenal biopsy specimens taken both at the time of the CD diagnosis and at the first endoscopic control after 18-24 months on GFD were evaluated...
October 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29016564/the-role-of-an-iga-igg-deamidated-gliadin-peptide-point-of-care-test-in-predicting-persistent-villous-atrophy-in-patients-with-celiac-disease-on-a-gluten-free-diet
#6
Michelle S Lau, Peter D Mooney, William L White, Michael A Rees, Simon H Wong, Matthew Kurien, Nick Trott, Daniel A Leffler, Marios Hadjivassiliou, David S Sanders
OBJECTIVES: Mucosal healing is important in celiac disease (CD) for the prevention of complications. However, obtaining duodenal biopsies is invasive, and there is currently no reliable surrogate marker for histological remission in clinical practice. We aimed to assess the role of a point-of-care test (POCT) based on IgA/IgG-deamidated gliadin peptide, in detecting persistent villous atrophy (VA) in CD. METHODS: We prospectively recruited patients with CD attending endoscopy for the assessment of histological remission...
October 10, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28993260/improved-bone-microarchitecture-in-patients-with-celiac-disease-after-3-years-on-a-gluten-free-diet
#7
María B Zanchetta, Ana F Costa, Vanesa Longobardi, Roberto Mazure, Fernando Silveira, María P Temprano, Horacio Vázquez, César Bogado, Sonia I Niveloni, Edgardo Smecuol, María L Moreno, Andrea González, Eduardo Mauriño, José R Zanchetta, Julio C Bai
No abstract text is available yet for this article.
October 6, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28991835/celiac-disease-diagnosis-without-biopsy-is-a-10x-uln-anti-transglutaminase-result-suitable-for-a-chemiluminescence-method
#8
Giulia Previtali, Lisa Licini, Lorenzo D'Antiga, Antonio Marseglia, Rudi Ravasio, Francesca Nembrini, Salvatore Greco, Aurelio Sonzogni, Giovanna Azzarà, Paolo Ravelli, Maria Grazia Alessio
OBJECTIVES: 2012 ESPGHAN guidelines allow to establish a celiac disease (CD) diagnosis without duodenal biopsy in symptomatic pediatric patients with anti-tissue transglutaminase (anti-tTG) titers > 10 times the upper limit of normal (ULN). For some years now, new chemiluminescence immunoassays have been made available: it is important to establish the clinical performance of anti-tTG and to determine the cut-off best suited to predict Marsh ≥ 2 in order to avoid gastrointestinal endoscopy not only in children, but also in the adult population...
October 6, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28974086/renal-disease-in-patients-with-celiac-disease-a-review
#9
Boonphiphop Boonpheng, Wisit Cheungpasitporn, Karn Wijarnpreecha
Celiac disease, an inflammatory disease of small bowel caused by sensitivity to dietary gluten and related protein, affects approximately 0.5-1% of the population in the Western world. Extraintestinal symptoms and associated diseases are increasingly recognized including diabetes mellitus type 1, thyroid disease, dermatitis herpetiformis and ataxia. There have also been a number of reports of various types of renal involvement in patients with celiac disease including diabetes nephropathy, IgA nephropathy, membranous nephropathy, membranoproliferative glomerulonephritis, nephrotic syndrome related to malabsorption, oxalate nephropathy, and associations of celiac disease with chronic kidney disease and end-stage kidney disease...
October 3, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28963718/tritordeum-a-novel-cereal-for-food-processing-with-good-acceptability-and-significant-reduction-in-gluten-immunogenic-peptides-in-comparison-with-wheat
#10
Luis Vaquero, Isabel Comino, Santiago Vivas, Laura Rodríguez-Martín, María J Giménez, Jorge Pastor, Carolina Sousa, Francisco Barro
BACKGROUND: Tritordeum is a novel cereal obtained from the hybridisation between durum wheat and a wild barley. This study evaluates acceptance, digestibility and immunotoxic properties of tritordeum, a novel cereal for food processing. Nineteen healthy volunteers participated in a study with different diets to compare tritordeum bread with wheat and gluten-free breads. RESULTS: Tritordeum breads had a similar acceptance to the wheat bread usually consumed and the acceptance was significantly higher than the gluten-free bread and the standardized wheat bread supplied in the study...
September 30, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28953524/iron-status-in-pediatric-celiac-disease-a-retrospective-chart-review
#11
Jelena Popov, Mina Baldawi, Lawrence Mbuagbaw, Michelle Gould, Heather Mileski, Herbert Brill, Nikhil Pai
This study assessed the role of serum ferritin as a non-invasive biomarker in the diagnosis and monitoring of pediatric celiac disease. A retrospective chart review was performed on patients < 18 years old at time of diagnosis (n = 193) between 1998-2015. 653 paired values demonstrated a weak negative correlation between serum ferritin and TTG-IgA (r = -0.114; p = 0.004), necessitating further evaluation. A significant relationship was found between reduction of TTG-IgA and increase in serum ferritin after institution of a gluten-free diet (p < 0...
September 26, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28950706/efficacy-of-a-point-of-care-test-based-on-deamidated-gliadin-peptides-for-the-detection-of-celiac-disease-in-pediatric-patients
#12
Isabel Polanco, Thabata Koester Weber, Eva Martínez-Ojinaga, Manuel Molina, Jesús Sarria
OBJECTIVE: The objective of the study was to assess the effectiveness of a point-of-care test (POCT) based on deamidated gliadin peptides (DGP) compared to the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) criteria diagnosis in the early detection of celiac disease (CD) in pediatric patients. METHODS: One hundred children (≤ 18 years) with suspected CD were selected, including siblings of celiac children that underwent gastroscopy for other gastrointestinal conditions...
September 27, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28940785/transglutaminases-in-autoimmune-and-inherited-skin-diseases-the-phenomena-of-epitope-spreading-and-functional-compensation
#13
REVIEW
Sarolta Kárpáti, Miklós Sárdy, Krisztián Németh, Balázs Mayer, Neil Smyth, Mats Paulsson, Heiko Traupe
Transglutaminases (TGs) are structurally and functionally related enzymes that modify the posttranslational structure and activity of proteins or peptides, and thus are able to turn on or switch off their function. Depending on location and activities, TGs are able to modify the signaling, the function and the fate of cells and extracellular connective tissues. Beside mouse models also human diseases enable us to appreciate the function of various TGs. In this paper skin diseases induced by genetic damages or autoimmune targeting of these enzymes will be discussed...
September 23, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28936206/an-in-vitro-fermentation-study-on-the-effects-of-gluten-friendly-tm-bread-on-microbiota-and-short-chain-fatty-acids-of-fecal-samples-from-healthy-and-celiac-subjects
#14
Adele Costabile, Triana Bergillos-Meca, Loretta Landriscina, Antonio Bevilacqua, Isidro Gonzalez-Salvador, Maria R Corbo, Leonardo Petruzzi, Milena Sinigaglia, Carmela Lamacchia
Recently, an innovative gluten detoxification method called Gluten Friendly(TM) (GF) has been developed. It induces structural modifications, which abolish the antigenic capacity of gluten and reduce the in vitro immunogenicity of the most common epitopes involved in celiac disease, without compromising the nutritional and technological properties. This study investigated the in vitro effects of GF bread (GFB) on the fecal microbiota from healthy and celiac individuals by a three-stage continuous fermentative system, which simulates the colon (vessel 1, proximal colon; vessel 2, transverse colon; and vessel 3, distal colon), as well as on the production of short chain fatty acids (SCFA, acetate, propionate, butyrate)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28934294/immunopathology-of-childhood-celiac-disease-key-role-of-intestinal-epithelial-cells
#15
Grzegorz Pietz, Rituparna De, Maria Hedberg, Veronika Sjöberg, Olof Sandström, Olle Hernell, Sten Hammarström, Marie-Louise Hammarström
BACKGROUND & AIMS: Celiac disease is a chronic inflammatory disease of the small intestine mucosa due to permanent intolerance to dietary gluten. The aim was to elucidate the role of small intestinal epithelial cells in the immunopathology of celiac disease in particular the influence of celiac disease-associated bacteria. METHODS: Duodenal biopsies were collected from children with active celiac disease, treated celiac disease, and clinical controls. Intestinal epithelial cells were purified and analyzed for gene expression changes at the mRNA and protein levels...
2017: PloS One
https://www.readbyqxmd.com/read/28934109/intestinal-production-of-anti-tissue-transglutaminase-2-antibodies-in-patients-with-diagnosis-other-than-celiac-disease
#16
Mariantonia Maglio, Fabiana Ziberna, Rosita Aitoro, Valentina Discepolo, Giuliana Lania, Virginia Bassi, Erasmo Miele, Tarcisio Not, Riccardo Troncone, Renata Auricchio
It has been hypothesized that gluten-dependent production of anti-tissue-transglutaminase 2 (anti-TG2) antibodies may occur only at an intestinal level. We have investigated intestinal production of anti-TG2 antibodies in 136 patients with normal serum levels of anti-TG2 antibodies and normal duodenal mucosa. Intestinal deposits of anti-TG2 antibodies were evaluated by immunofluorescence and anti-TG2 antibodies released in organ culture supernatants measured by ELISA. Intestinal antibody libraries were obtained from 10 subjects...
September 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28932354/cardiovascular-involvement-in-celiac-disease
#17
REVIEW
Edward J Ciaccio, Suzanne K Lewis, Angelo B Biviano, Vivek Iyer, Hasan Garan, Peter H Green
Celiac disease (CD) is an autoimmune response to ingestion of gluten protein, which is found in wheat, rye, and barley grains, and results in both small intestinal manifestations, including villous atrophy, as well as systemic manifestations. The main treatment for the disease is a gluten-free diet (GFD), which typically results in the restoration of the small intestinal villi, and restoration of other affected organ systems, to their normal functioning. In an increasing number of recently published studies, there has been great interest in the occurrence of alterations in the cardiovascular system in untreated CD...
August 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28931034/primary-care-physicians-are-under-testing-for-celiac-disease-in-patients-with-iron-deficiency-anemia-results-of-a-national-survey
#18
Marisa Spencer, Adrienne Lenhart, Jason Baker, Joseph Dickens, Arlene Weissman, Andrew J Read, Seema Saini, Sameer D Saini
BACKGROUND: Iron deficiency anemia (IDA) is a common extra-intestinal manifestation of celiac disease (CD). Little is known about the frequency with which primary care physicians (PCPs) test for CD in patients with IDA. We aimed to describe how PCPs approach testing for CD in asymptomatic patients with IDA. METHODS: We electronically distributed a survey to PCPs who are members of the American College of Physicians. Respondents were asked whether they would test for CD (serologic testing, refer for esophagogastroduodenoscopy [EGD], or refer to GI) in hypothetical patients with new IDA, including: (1) a young Caucasian man, (2) a premenopausal Caucasian woman, (3) an elderly Caucasian man, and (4) a young African American man...
2017: PloS One
https://www.readbyqxmd.com/read/28928668/re-challenge-studies-in-non-celiac-gluten-sensitivity-a-systematic-review-and-meta-analysis
#19
Elena Lionetti, Alfredo Pulvirenti, Martina Vallorani, Giulia Catassi, Anil K Verma, Simona Gatti, Carlo Catassi
Background: Non-celiac gluten sensitivity (NCGS) is a clinical entity characterized by intestinal and/or extra-intestinal symptoms related to the ingestion of gluten in individuals that are not affected by either celiac disease (CD) or wheat allergy (WA). Since we do not have specific biomarkers for NCGS, the diagnosis is based on the evidence of a clear relationship between the ingestion of gluten (re-challenge) and clinical symptoms, after a remission during the gluten-free diet (GFD). Several re-challenge studies have been published so far to evaluate the real prevalence of NCGS, reporting conflicting results...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28928632/neurophysiology-of-the-celiac-brain-disentangling-gut-brain-connections
#20
REVIEW
Manuela Pennisi, Alessia Bramanti, Mariagiovanna Cantone, Giovanni Pennisi, Rita Bella, Giuseppe Lanza
Celiac disease (CD) can be considered a complex multi-organ disorder with highly variable extra-intestinal, including neurological, involvement. Cerebellar ataxia, peripheral neuropathy, seizures, headache, cognitive impairment, and neuropsychiatric diseases are complications frequently reported. These manifestations may be present at the onset of the typical disease or become clinically evident during its course. However, CD subjects with subclinical neurological involvement have also been described, as well as patients with clear central and/or peripheral nervous system and intestinal histopathological disease features in the absence of typical CD manifestations...
2017: Frontiers in Neuroscience
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