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JOURNAL ARTICLE
Archana Patel, Carla M Bann, Vanessa R Thorsten, Sowmya R Rao, Adrien Lokangaka, Antoinette Tshefu Kitoto, Melissa Bauserman, Lester Figueroa, Nancy F Krebs, Fabian Esamai, Sherri Bucher, Sarah Saleem, Robert L Goldenberg, Elwyn Chomba, Waldemar A Carlo, Shivaprasad Goudar, Richard Derman, Marion Koso-Thomas, Elizabeth McClure, Patricia L Hibberd
OBJECTIVES: We examined gestational age (GA) estimates for live and still births, and prematurity rates based on last menstrual period (LMP) compared with ultrasonography (USG) among pregnant women at seven sites in six low-resource countries. DESIGN: Prospective cohort study SETTING AND PARTICIPANTS: This study included data from the Global Network's population-based Maternal and Newborn Health Registry which follows pregnant women in six low-income and middle-income countries (Democratic Republic of the Congo, Guatemala, India, Kenya, Pakistan and Zambia)...
September 20, 2023: BMJ Open
#22
JOURNAL ARTICLE
Jean-Luc Balligand, Dulce Brito, Oana Brosteanu, Barbara Casadei, Christophe Depoix, Frank Edelmann, Vanessa Ferreira, Gerasimos Filippatos, Bernhard Gerber, Damien Gruson, Dirk Hasenclever, Kristian Hellenkamp, Ignatios Ikonomidis, Bartosz Krakowiak, Renaud Lhommel, Masliza Mahmod, Stefan Neubauer, Alexandre Persu, Stefan Piechnik, Burkert Pieske, Elisabeth Pieske-Kraigher, Fausto Pinto, Piotr Ponikowski, Michele Senni, Jean-Noël Trochu, Nancy Van Overstraeten, Rolf Wachter, Anne-Catherine Pouleur
IMPORTANCE: Left ventricular (LV) hypertrophy contributes to the onset and progression of heart failure (HF), particularly for patients with pre-HF (stage B) for whom no treatment has yet proven effective to prevent transition to overt HF (stage C). The β3-adrenergic receptors (β3ARs) may represent a new target, as their activation attenuates LV remodeling. OBJECTIVE: To determine whether activation of β3ARs by repurposing a β3AR agonist, mirabegron, is safe and effective in preventing progression of LV hypertrophy and diastolic dysfunction among patients with pre- or mild HF...
September 20, 2023: JAMA Cardiology
#23
JOURNAL ARTICLE
Gandhi Fernando Pavón-Romero, Ramcés Falfán-Valencia, Katia Vanessa Gutiérrez-Quiroz, Estivaliz Arizel De La O-Espinoza, Nancy Haydée Serrano-Pérez, Fernando Ramírez-Jiménez, Luis M Teran
PURPOSE: To describe the lung function and clinical control of asthma in patients with N-ERD during three years of medical follow-up using GINA guidelines. METHODS: We evaluated 75 N-ERD and 68 asthma patients (AG). Clinical control, lung function, and asthma treatment were evaluated according to GINA-2014. We compared all variables at baseline and one, two, and three years after treatment. RESULTS: At baseline, the N-ERD group had better basal lung function (LF) than the AG group ( p <0...
2023: Journal of Asthma and Allergy
#24
Rafael Adrián Pacheco Orozco, Alejandro Padilla-Guzmán, Jessica María Forero-Delgadillo, Vanessa Amparo Ochoa Jiménez, Harry Pachajoa, Nancy Janeth Vargas Parra, Jaime M Restrepo
BACKGROUND: Schimke immune-osseous dysplasia (SIOD) is an ultra-rare multisystemic, monogenic, and autosomal recessive inherited disease caused by biallelic mutations in the SMARCAL1 gene. Approximately 100 cases have been reported worldwide. The disease is characterized by skeletal, renal, and immunological abnormalities. CASE DESCRIPTION: This is a 6-year-old female patient who debuted with nephrotic syndrome at five years of age, with a switch to corticosteroid resistance and poor response to immunosuppressive treatment received...
December 2023: Molecular Genetics and Metabolism Reports
#25
JOURNAL ARTICLE
Teresa Rognoni, Marta Fernandez-Matarrubia, Miguel Ángel Martinez-González, Jordi Salas-Salvadó, Dolores Corella, Olga Castañer, J Alfredo Martínez, Ángel M Alonso-Gómez, Enrique Gómez-Gracia, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramón Estruch, Francisco J Tinahones, José Manuel Santos-Lozano, Lluis Serra-Majem, Naomi Cano Ibañez, Josep A Tur, Rafael Micó Pérez, Xavier Pintó, Miguel Delgado-Rodríguez, María Ortiz Ramos, Josep Vidal Martín, Clotilde Vázquez, Lidia Daimiel, Emili Ros, Nuria Goñi-Ruiz, Nancy Babio, José V Sorlí, Helmut Schröder, Antonio García-Rios, Laura Compañ-Gabucio, Julia Warnberg, M Ángeles Zulet, Alice Chaplin, Emilio Sacanella, Amira Bouzalmate-Hajjaj, Lucas Tojal-Sierra, Miguel Damas-Fuentes, Zenaida Vázquez, Carlos Gómez-Martínez, Carmen Saiz, Mireia Malcampo, Ana M Ortiz-Morales, Vanessa Martínez-Avilés, Jesús García-Gavilan, Itziar Abete, Montserrat Fitó, Estefanía Toledo
BACKGROUND: It has been proposed that physical activity (PA) could prevent cognitive decline. OBJECTIVE: To evaluate the association between changes in PA and changes in cognitive function in a cohort of adults with metabolic syndrome. METHODS: Longitudinal observational study including 5,500 adults (mean age 65 years, SD = 5; women = 49.3%) with metabolic syndrome. Participants underwent physical activity measurements and cognitive evaluation at baseline and at two-years of follow-up...
August 25, 2023: Journal of Alzheimer's Disease: JAD
#26
JOURNAL ARTICLE
Jackie K Patterson, Vanessa R Thorsten, Barry Eggleston, Tracy Nolen, Adrien Lokangaka, Antoinette Tshefu, Shivaprasad S Goudar, Richard J Derman, Elwyn Chomba, Waldemar A Carlo, Manolo Mazariegos, Nancy F Krebs, Sarah Saleem, Robert L Goldenberg, Archana Patel, Patricia L Hibberd, Fabian Esamai, Edward A Liechty, Rashidul Haque, Bill Petri, Marion Koso-Thomas, Elizabeth M McClure, Carl L Bose, Melissa Bauserman
BACKGROUND: Low birth weight (LBW, < 2500 g) infants are at significant risk for death and disability. Improving outcomes for LBW infants requires access to advanced neonatal care, which is a limited resource in low- and middle-income countries (LMICs). Predictive modeling might be useful in LMICs to identify mothers at high-risk of delivering a LBW infant to facilitate referral to centers capable of treating these infants. METHODS: We developed predictive models for LBW using the NICHD Global Network for Women's and Children's Health Research Maternal and Newborn Health Registry...
August 22, 2023: BMC Pregnancy and Childbirth
#27
JOURNAL ARTICLE
Mei-Tsan Kuo, Jack F Raffaelle, Ellise McKenna Waller, Vanessa A Varaljay, Dominique Wagner, Nancy Kelley-Loughnane, Nigel F Reuel
Enzymatic biodegradation is a promising method to reclaim plastic materials. However, to date, a high-throughput method for screening potential enzyme candidates for biodegradation is still lacking. Here, we propose a single-walled carbon nanotube (SWCNT) fluorescence sensor for screening the enzymatic degradation of polyester polyurethane nanoparticles. Through wrapping the SWCNT with cationic chitosan, an electrostatic bond is formed between the SWCNT and Impranil, a widely applied model substrate of polyester polyurethane...
August 22, 2023: ACS Nano
#28
JOURNAL ARTICLE
Kartik Shankar, Kay Hwang, Jamie L Westcott, Sarah Saleem, Sumera A Ali, Saleem Jessani, Archana Patel, Avinash Kavi, Manjunath S Somannavar, Shivaprasad S Goudar, Patricia L Hibberd, Richard J Derman, Matthew Hoffman, Blair J Wylie, Robert L Goldenberg, Vanessa R Thorsten, Elizabeth M McClure, Nancy F Krebs
OBJECTIVE: Growing evidence suggests that environmental heat stress negatively influences fetal growth and pregnancy outcomes. However, few studies have examined the impact of heat stress on pregnancy outcomes in low-resource settings. We combined data from a large multi-country maternal-child health registry and meteorological data to assess the impacts of heat stress. DESIGN: Retrospective cohort study. SETTING: Three sites based in south Asia as part of the Global Network for Women's and Children's Health research in India (Belagavi and Nagpur) and Pakistan (Thatta)...
November 2023: BJOG: An International Journal of Obstetrics and Gynaecology
#29
JOURNAL ARTICLE
Stephanie Stanelle-Bertram, Sebastian Beck, Nancy Kouassi Mounogou, Berfin Schaumburg, Fabian Stoll, Amirah Al Jawazneh, Zoé Schmal, Tian Bai, Martin Zickler, Georg Beythien, Kathrin Becker, Madeleine de la Roi, Fabian Heinrich, Claudia Schulz, Martina Sauter, Susanne Krasemann, Philine Lange, Axel Heinemann, Debby van Riel, Lonneke Leijten, Lisa Bauer, Thierry P P van den Bosch, Boaz Lopuhaä, Tobias Busche, Daniel Wibberg, Dirk Schaudien, Torsten Goldmann, Anna Lüttjohann, Jenny Ruschinski, Hanna Jania, Zacharias Müller, Vinicius Pinho Dos Reis, Vanessa Krupp-Buzimkic, Martin Wolff, Chiara Fallerini, Margherita Baldassarri, Simone Furini, Katrina Norwood, Christopher Käufer, Nina Schützenmeister, Maren von Köckritz-Blickwede, Maria Schroeder, Dominik Jarczak, Axel Nierhaus, Tobias Welte, Stefan Kluge, Alice C McHardy, Frank Sommer, Jörn Kalinowski, Susanne Krauss-Etschmann, Franziska Richter, Jan von der Thüsen, Wolfgang Baumgärtner, Karin Klingel, Benjamin Ondruschka, Alessandra Renieri, Gülsah Gabriel
Male sex represents one of the major risk factors for severe COVID-19 outcome. However, underlying mechanisms that mediate sex-dependent disease outcome are as yet unknown. Here, we identify the CYP19A1 gene encoding for the testosterone-to-estradiol metabolizing enzyme CYP19A1 (also known as aromatase) as a host factor that contributes to worsened disease outcome in SARS-CoV-2-infected males. We analyzed exome sequencing data obtained from a human COVID-19 cohort (n = 2,866) using a machine-learning approach and identify a CYP19A1-activity-increasing mutation to be associated with the development of severe disease in men but not women...
August 11, 2023: Cell reports medicine
#30
JOURNAL ARTICLE
Incidence and prevalence of traumatic spinal cord injury in Canada using health administrative data.
Nancy P Thorogood, Vanessa K Noonan, Xiaozhi Chen, Nader Fallah, Suzanne Humphreys, Nicolas Dea, Brian K Kwon, Marcel F Dvorak
INTRODUCTION: Incidence and prevalence data are needed for the planning, funding, delivery and evaluation of injury prevention and health care programs. The objective of this study was to estimate the Canadian traumatic spinal cord injury (TSCI) incidence, prevalence and trends over time using national-level health administrative data. METHODS: ICD-10 CA codes were used to identify the cases for the hospital admission and discharge incidence rates of TSCI in Canada from 2005 to 2016...
2023: Frontiers in Neurology
#31
JOURNAL ARTICLE
Helen Wefers, Vanessa Krüger, Nancy Beatriz Iza Simba, Yuri Amaya Guandinango
Using the example of a psychological research project in the Andean context, this explorative interview study adds to the current debate about ethical challenges of psychological cross-cultural research projects by being one of the first to address those challenges empirically. Using a multilevel approach, we conducted interviews with three groups of experts (study participants, i.e., Kichwa mothers, research assistants and experts on research in Indigenous communities in Ecuador; N = 10). Overall, the thematic analysis identified that the establishment of horizontal research relationships allows the best adaption to context-specific values (e...
June 20, 2023: Journal of Empirical Research on Human Research Ethics: JERHRE
#32
RANDOMIZED CONTROLLED TRIAL
Nancy Dorvil, Vanessa R Rivera, Cynthia Riviere, Richard Berman, Patrice Severe, Heejung Bang, Kerlyne Lavoile, Jessy G Devieux, Mikerlyne Faustin, Giovanni Saintyl, Maria Duran Mendicuti, Samuel Pierre, Alexandra Apollon, Emelyne Dumond, Guyrlaine Pierre Louis Forestal, Vanessa Rouzier, Adias Marcelin, Margaret L McNairy, Kathleen F Walsh, Kathryn Dupnik, Lindsey K Reif, Anthony L Byrne, Stephanie Bousleiman, Eli Orvis, Patrice Joseph, Pierre-Yves Cremieux, Jean William Pape, Serena P Koenig
BACKGROUND: Same-day HIV testing and antiretroviral therapy (ART) initiation is being widely implemented. However, the optimal timing of ART among patients with tuberculosis (TB) symptoms is unknown. We hypothesized that same-day treatment (TB treatment for those diagnosed with TB; ART for those not diagnosed with TB) would be superior to standard care in this population. METHODS AND FINDINGS: We conducted an open-label trial among adults with TB symptoms at initial HIV diagnosis at GHESKIO in Haiti; participants were recruited and randomized on the same day...
June 2023: PLoS Medicine
#33
Tyler B Waltz, Dongman Chao, Eve K Prodoehl, Vanessa L Ehlers, Bhavya S Dharanikota, Nancy M Dahms, Elena Isaeva, Quinn H Hogan, Bin Pan, Cheryl L Stucky
Patients with Fabry disease suffer from chronic debilitating pain and peripheral sensory neuropathy with minimal treatment options, but the cellular drivers of this pain are unknown. Here, we propose a novel mechanism by which altered signaling between Schwann cells and sensory neurons underlies the peripheral sensory nerve dysfunction we observe in a genetic rat model of Fabry disease. Using in vivo and in vitro electrophysiological recordings, we demonstrate that Fabry rat sensory neurons exhibit pronounced hyperexcitability...
May 28, 2023: bioRxiv
#34
JOURNAL ARTICLE
Ella S Kim, Arjun Rajan, Kathleen Chang, Sanath Govindarajan, Clara Gulick, Eva English, Bianca Rodriguez, Orion Bloomfield, Stella Nakada, Charlotte Beard, Sarah O'Connor, Sophia Mastroianni, Emma Downey, Matthew Feigenbaum, Caitlin Tolentino, Abigail Pace, Marina Khan, Soyoun Moon, Jordan DiPrima, Amber Syed, Flora Lin, Yasmina Abukhadra, Isabella Bacon, John Beckerle, Sophia Cho, Nana Esi Donkor, Lucy Garberg, Ava Harrington, Mai Hoang, Nosa Lawani, Ayush Noori, Euwie Park, Ella Parsons, Philip Oravitan, Matthew Chen, Cristian Molina, Caleb Richmond, Adith Reddi, Jason Huang, Cooper Shugrue, Rose Coviello, Selma Unver, Matthew Indelicarto, Emir Islamovic, Rosemary McIlroy, Alana Yang, Mahdi Hamad, Elizabeth Griffin, Zara Ahmed, Asha Alla, Patricia Fitzgerald, Audrey Choi, Tanya Das, Yuchen Cheng, Joshua Yu, Tabor Roderiques, Ethan Lee, Longchao Liu, Jaekeb Harper, Jason Wang, Chris Suhr, Max Tan, Jacqueline Luque, A Russell Tam, Emma Chen, Max Triff, Lyric Zimmermann, Eric Zhang, Jackie Wood, Kaitlin Clark, Nat Kpodonu, Antar Dey, Alexander Ecker, Maximilian Chuang, Ramón Kodi Suzuki López, Harry Sun, Zijing Wei, Henry Stone, Chia Yu Joy Chi, Aiden Silvestri, Petra Orloff, Neha Nedumaran, Aletheia Zou, Leyla Ünver, Oscair Page, Minseo Kim, Terence Yan Tao Chan, Akili Tulloch, Andrea Hernandez, Aruli Pillai, Caitlyn Chen, Neil Chowdhury, Lina Huang, Anish Mudide, Garrett Paik, Alexandra Wingate, Lily Quinn, Chris Conybere, Luca Laiza Baumgardt, Rollo Buckley, Zara Kolberg, Ruth Pattison, Ashlyn Ahmad Shazli, Pia Ganske, Luca Sfragara, Annina Strub, Barney Collier, Hari Tamana, Dylan Ravindran, James Howden, Madeleine Stewart, Sakura Shimizu, Julia Braniff, Melanie Fong, Lucy Gutman, Danny Irvine, Sahil Malholtra, Jillian Medina, John Park, Alicia Yin, Harrison Abromavage, Breanna Barrett, Jacqueline Chen, Rachelle Cho, Mac Dilatush, Gabriel Gaw, Caitlin Gu, Jupiter Huang, Houston Kilby, Ethan Markel, Katie McClure, William Phillips, Benjamin Polaski, Amelia Roselli, Soleil Saint-Cyr, Ellie Shin, Kylan Tatum, Tai Tumpunyawat, Lucia Wetherill, Sara Ptaszynska, Maddie Zeleznik, Alexander Pesendorfer, Anna Nolan, Jeffrey Tao, Divya Sammeta, Laney Nicholson, Giao Vu Dinh, Merrin Foltz, An Vo, Maggie Ross, Andrew Tokarski, Samika Hariharan, Elaine Wang, Martha Baziuk, Ashley Tay, Yuk Hung Maximus Wong, Jax Floyd, Aileen Cui, Kieran Pierre, Nikita Coppisetti, Matthew Kutam, Dhruv Khurjekar, Anthony Gadzi, Ben Gubbay, Sophia Pedretti, Sofiya Belovich, Tiffany Yeung, Mercy Fey, Layla Shaffer, Arthur Li, Giancarlo Beritela, Kyle Huyghue, Greg Foster, Garrett Durso-Finley, Quinn Thierfelder, Holly Kiernan, Andrew Lenkowsky, Tesia Thomas, Nicole Cheng, Olivia Chao, Pia L'Etoile-Goga, Alexa King, Paris McKinley, Nicole Read, David Milberg, Leila Lin, Melinda Wong, Io Gilman, Samantha Brown, Lila Chen, Jordyn Kosai, Mark Verbinsky, Alice Belshaw-Hood, Honon Lee, Cathy Zhou, Maya Lobo, Asia Tse, Kyle Tran, Kira Lewis, Pratmesh Sonawane, Jonathan Ngo, Sophia Zuzga, Lillian Chow, Vianne Huynh, Wenyi Yang, Samantha Lim, Brandon Stites, Shannon Chang, Raenalyn Cruz-Balleza, Michaela Pelta, Stella Kujawski, Christopher Yuan, Elio Standen-Bloom, Oliver Witt, Karina Anders, Audrey Duane, Nancy Huynh, Benjamin Lester, Samantha Fung-Lee, Melanie Fung, Mandy Situ, Paolo Canigiula, Matijs Dijkgraaf, Wilbert Romero, Samantha Karmela Baula, Kimberly Wong, Ivana Xu, Benjamin Martinez, Reena Nuygen, Lucy Norris, Noah Nijensohn, Naomi Altman, Elise Maajid, Olivia Burkhardt, Jullian Chanda, Catherine Doscher, Alex Gopal, Aaron Good, Jonah Good, Nate Herrera, Lucas Lanting, Sophia Liem, Anila Marks, Emma McLaughlin, Audrey Lee, Collin Mohr, Emma Patton, Naima Pyarali, Claire Oczon, Daniel Richards, Nathan Good, Spencer Goss, Adeeb Khan, Reagan Madonia, Vivian Mitchell, Natasha Sun, Tarik Vranka, Diogo Garcia, Frida Arroyo, Eric Morales, Steven Camey, Giovanni Cano, Angelica Bernabe, Jennifer Arroyo, Yadira Lopez, Emily Gonzalez, Bryan Zumba, Josue Garcia, Esmeralda Vargas, Allen Trinidad, Noel Candelaria, Vanessa Valdez, Faith Campuzano, Emily Pereznegron, Jenifer Medrano, Jonathan Gutierrez, Evelyn Gutierrez, Ericka Taboada Abrego, Dayanara Gutierrez, Cristian Ortiz, Angelica Barnes, Eleanor Arms, Leo Mitchell, Ciara Balanzá, Jake Bradford, Harrison Detroy, Devin Ferguson, Ethel Guillermo, Anusha Manapragada, Daniella Nanula, Brigitte Serna, Khushi Singh, Emily Sramaty, Brian Wells, Matthew Wiggins, Melissa Dowling, Geraldine Schmadeke, Samantha Cafferky, Stephanie Good, Margaret Reese, Miranda Fleig, Alex Gannett, Cory Cain, Melody Lee, Paul Oberto, Jennifer Rinehart, Elaine Pan, Sallie Anne Mathis, Jessica Joiner, Leslie Barr, Cory J Evans, Alberto Baena-Lopez, Andrea Beatty, Jeanette Collette, Robert Smullen, Jeanne Suttie, Townley Chisholm, Cheryl Rotondo, Gareth Lewis, Victoria Turner, Lloyd Stark, Elizabeth Fox, Anjana Amirapu, Sangbin Park, Nicole Lantz, Anne E Rankin, Seung K Kim, Lutz Kockel
Conditional gene regulation in Drosophila through binary expression systems like the LexA-LexAop system provides a superb tool for investigating gene and tissue function. To increase the availability of defined LexA enhancer trap insertions, we present molecular, genetic and tissue expression studies of 301 novel Stan-X LexA enhancer traps derived from mobilization of the index SX4 line. This includes insertions into distinct loci on the X, II and III chromosomes that were not previously associated with enhancer traps or targeted LexA constructs, an insertion into ptc, and seventeen insertions into natural transposons...
June 6, 2023: G3: Genes—Genomes—Genetics
#35
JOURNAL ARTICLE
Vanessa Reynolds, Nancy L Van Buren, Jed B Gorlin
BACKGROUND: Blood center organizations (BCOs) have traditionally offered two gender choices (male or female) on the donor history questionnaire (DHQ). Our BCO was one of the first in the United States to offer additional options on our DHQ to improve the experience for gender nonconforming donors. STUDY DESIGN AND METHODS: Three years of data were analyzed from all blood donation visits between March 2019 and March 2022. Donors were stratified by gender categories and generation as follows: Gen Z, Millennial, Gen X, Boomers, and Silent...
July 2023: Transfusion
#36
JOURNAL ARTICLE
Nancy P Thorogood, Zeina Waheed, John Chernesky, Ian Burkhart, Judith Smith, Shannon Sweeney, Rob Wudlick, Sam Douglas, Di Wang, Vanessa K Noonan
BACKGROUND: Spinal cord stimulation (SCS) clinical trials are evaluating its efficacy and safety for motor, sensory, and autonomic recovery following spinal cord injury (SCI). The perspectives of people living with SCI are not well known and can inform the planning, delivery, and translation of SCS. OBJECTIVES: To obtain input from people living with SCI on the top priorities for recovery, expected meaningful benefits, risk tolerance, clinical trial design, and overall interest in SCS...
2023: Topics in Spinal Cord Injury Rehabilitation
#37
JOURNAL ARTICLE
Christina Marquez, Kelly Kazmierski, Jaqueline Arcos Carballo, Jackie Garcia, Vanessa Avalos, Lyric N Russo, Jose Arreola, Alyssa Hernandez Rodriguez, Allen A Perez, Francisca Leal, Gina Torres, Gloria Montiel, Nancy Guerra, Jessica L Borelli
COVID-19 has disproportionately affected the Latinx community, leading to heightened economic instability and increased mortality/morbidity. Frontline community health workers ( promotoras ) have played an integral role in serving low-income Latinx immigrant communities, disseminating health information to this vulnerable community while also facing heightened risks to their own health and wellbeing. This study explores the impact of the pandemic on Latinx communities and the promotoras that serve them, examining how the stresses and inequities the pandemic wrought might be mitigated...
April 6, 2023: Journal of Latina/o Psychology
#38
JOURNAL ARTICLE
Vanessa Schmithorst, Rafael Ceschin, Vincent Lee, Julia Wallace, Aurelia Sahel, Thomas L Chenevert, Hemant Parmar, Jeffrey I Berman, Arastoo Vossough, Deqiang Qiu, Nadja Kadom, Patricia Ellen Grant, Borjan Gagoski, Peter S LaViolette, Mohit Maheshwari, Lynn A Sleeper, David C Bellinger, Dawn Ilardi, Sharon O'Neil, Thomas A Miller, Jon Detterich, Kevin D Hill, Andrew M Atz, Marc E Richmond, James Cnota, William T Mahle, Nancy S Ghanayem, J William Gaynor, Caren S Goldberg, Jane W Newburger, Ashok Panigrahy
Patients with hypoplastic left heart syndrome who have been palliated with the Fontan procedure are at risk for adverse neurodevelopmental outcomes, lower quality of life, and reduced employability. We describe the methods (including quality assurance and quality control protocols) and challenges of a multi-center observational ancillary study, SVRIII (Single Ventricle Reconstruction Trial) Brain Connectome. Our original goal was to obtain advanced neuroimaging (Diffusion Tensor Imaging and Resting-BOLD) in 140 SVR III participants and 100 healthy controls for brain connectome analyses...
April 30, 2023: Diagnostics
#39
Vanessa Schmithorst, Rafael Ceschin, Vince Lee, Julia Wallace, Aurelia Sahel, Thomas Chenevert, Hemant Parmar, Jeffrey I Berman, Arastoo Vossough, Deqiang Qiu, Nadja Kadom, Patricia Ellen Grant, Borjan Gagoski, Peter LaViolette, Mohit Maheshwari, Lynn A Sleeper, David Bellinger, Dawn Ilardi, Sharon Oâ Neil, Thomas A Miller, Jon Detterich, Kevin D Hill, Andrew M Atz, Marc Richmond, James Cnota, William T Mahle, Nancy Ghanayem, William Gaynor, Caren S Goldberg, Jane W Newburger, Ashok Panigrahy
UNLABELLED: Patients with hypoplastic left heart syndrome who have been palliated with the Fontan procedure are at risk for adverse neurodevelopmental outcomes, lower quality of life, and reduced employability. We describe the methods (including quality assurance and quality control protocols) and challenges of a multi-center observational ancillary study, SVRIII (Single Ventricle Reconstruction Trial) Brain Connectome. Our original goal was to obtain advanced neuroimaging (Diffusion Tensor Imaging and Resting-BOLD) in 140 SVR III participants and 100 healthy controls for brain connectome analyses...
April 17, 2023: medRxiv
#40
JOURNAL ARTICLE
Alexandra Bowen, Sara Gómez-Trillos, Geoffrey Curran, Kristi D Graves, Vanessa B Sheppard, Marc D Schwartz, Beth N Peshkin, Claudia Campos, Nathaly Garcés, Chiranjeev Dash, Luisa Aburto, Nancy Valencia-Rojas, Gina Hernández, Antonio Villa, Paula Cupertino, Pilar Carrera, Alejandra Hurtado-de-Mendoza
Genetic counseling and testing (GCT) inform cancer management for persons at risk for hereditary breast and ovarian cancer (HBOC). Community-based organizations (CBOs) may play a role in identifying at-risk Latinx individuals to connect them to GCT but data are lacking. Two academic centers and their four CBO partners planned to implement a validated questionnaire for HBOC risk screening ("HBOC risk screening tool"). This study aimed to assess CBO's preferences for HBOC risk screening tools, as well as the barriers and facilitators anticipated for future implementation...
April 16, 2023: Journal of Genetic Counseling
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