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https://www.readbyqxmd.com/read/27880749/early-diagnosis-of-hiv-infection-in-infants-one-caribbean-and-six-sub-saharan-african-countries-2011-2015
#1
Karidia Diallo, Andrea A Kim, Shirley Lecher, Dennis Ellenberger, R Suzanne Beard, Helen Dale, Mackenzie Hurlston, Molly Rivadeneira, Peter N Fonjungo, Laura N Broyles, Guoqing Zhang, Katrina Sleeman, Shon Nguyen, Steve Jadczak, Nadine Abiola, Raimi Ewetola, Jérémie Muwonga, Franck Fwamba, Christina Mwangi, Mary Naluguza, Charles Kiyaga, Isaac Ssewanyana, Deyde Varough, Domercant Wysler, David Lowrance, Frantz Jean Louis, Olbeg Desinor, Josiane Buteau, Francois Kesner, Vanessa Rouzier, Nat Segaren, Tessa Lewis, Abdoulaye Sarr, Geoffrey Chipungu, Sundeep Gupta, Daniel Singer, Reuben Mwenda, Hilary Kapoteza, Zawadi Chipeta, Nancy Knight, Sergio Carmona, William MacLeod, Gayle Sherman, Yogan Pillay, Clement B Ndongmo, Bridget Mugisa, Annie Mwila, James McAuley, Peter J Chipimo, Wezi Kaonga, Dailess Nsofwa, Davy Nsama, Fales Zulu Mwamba, Crispin Moyo, Clement Phiri, Marie-Yolande Borget, Leonard Ya-Kouadio, Abo Kouame, Christiane A Adje-Toure, John Nkengasong
Pediatric human immunodeficiency virus (HIV) infection remains an important public health issue in resource-limited settings. In 2015, 1.4 million children aged <15 years were estimated to be living with HIV (including 170,000 infants born in 2015), with the vast majority living in sub-Saharan Africa (1). In 2014, 150,000 children died from HIV-related causes worldwide (2). Access to timely HIV diagnosis and treatment for HIV-infected infants reduces HIV-associated mortality, which is approximately 50% by age 2 years without treatment (3)...
November 25, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27720260/dissonant-health-transition-in-the-states-of-mexico-1990-2013-a-systematic-analysis-for-the-global-burden-of-disease-study-2013
#2
Héctor Gómez-Dantés, Nancy Fullman, Héctor Lamadrid-Figueroa, Lucero Cahuana-Hurtado, Blair Darney, Leticia Avila-Burgos, Ricardo Correa-Rotter, Juan A Rivera, Simon Barquera, Eduardo González-Pier, Tania Aburto-Soto, Elga Filipa Amorin de Castro, Tonatiuh Barrientos-Gutiérrez, Ana C Basto-Abreu, Carolina Batis, Guilherme Borges, Ismael Campos-Nonato, Julio C Campuzano-Rincón, Alejandra de Jesús Cantoral-Preciado, Alejandra G Contreras-Manzano, Lucia Cuevas-Nasu, Vanessa V de la Cruz-Gongora, Jose L Diaz-Ortega, María de Lourdes García-García, Armando Garcia-Guerra, Teresita González de Cossío, Luz D González-Castell, Ileana Heredia-Pi, Marta C Hijar-Medina, Alejandra Jauregui, Aida Jimenez-Corona, Nancy Lopez-Olmedo, Carlos Magis-Rodríguez, Catalina Medina-Garcia, Maria E Medina-Mora, Fabiola Mejia-Rodriguez, Julio C Montañez, Pablo Montero, Alejandra Montoya, Grea L Moreno-Banda, Andrea Pedroza-Tobías, Rogelio Pérez-Padilla, Amado D Quezada, Vesta L Richardson-López-Collada, Horacio Riojas-Rodríguez, Maria J Ríos Blancas, Christian Razo-Garcia, Martha P Romero Mendoza, Tania G Sánchez-Pimienta, Luz M Sánchez-Romero, Astrid Schilmann, Edson Servan-Mori, Teresa Shamah-Levy, Martha M Téllez-Rojo, José L Texcalac-Sangrador, Haidong Wang, Theo Vos, Mohammad H Forouzanfar, Mohsen Naghavi, Alan D Lopez, Christopher J L Murray, Rafael Lozano
BACKGROUND: Child and maternal health outcomes have notably improved in Mexico since 1990, whereas rising adult mortality rates defy traditional epidemiological transition models in which decreased death rates occur across all ages. These trends suggest Mexico is experiencing a more complex, dissonant health transition than historically observed. Enduring inequalities between states further emphasise the need for more detailed health assessments over time. The Global Burden of Diseases, Injuries, and Risk Factors Study 2013 (GBD 2013) provides the comprehensive, comparable framework through which such national and subnational analyses can occur...
October 5, 2016: Lancet
https://www.readbyqxmd.com/read/27680696/erratum-replication-fork-stability-confers-chemoresistance-in-brca-deficient-cells
#3
Arnab Ray Chaudhuri, Elsa Callen, Xia Ding, Ewa Gogola, Alexandra A Duarte, Ji-Eun Lee, Nancy Wong, Vanessa Lafarga, Jennifer A Calvo, Nicholas J Panzarino, Sam John, Amanda Day, Anna Vidal Crespo, Binghui Shen, Linda M Starnes, Julian R de Ruiter, Jeremy A Daniel, Panagiotis A Konstantinopoulos, David Cortez, Sharon B Cantor, Oscar Fernandez-Capetillo, Kai Ge, Jos Jonkers, Sven Rottenberg, Shyam K Sharan, André Nussenzweig
No abstract text is available yet for this article.
September 28, 2016: Nature
https://www.readbyqxmd.com/read/27576584/impact-of-bladder-bowel-and-sexual-dysfunction-on-health-status-of-people-with-thoracolumbar-spinal-cord-injuries-living-in-the-community
#4
So Eyun Park, Stacy Elliott, Vanessa K Noonan, Nancy P Thorogood, Nader Fallah, Allan Aludino, Marcel F Dvorak
OBJECTIVE: The disruption of autonomic function following a spinal cord injury (SCI) is common and can negatively affect quality of life. The objective of this study was to describe the prevalence of bladder/bowel incontinence and sexual dysfunction in community-dwelling individuals with a thoracolumbar SCI and examine the impact on general physical and mental health status. METHODS: Participants who sustained a traumatic SCI to the thoracolumbar region of the spinal cord and classified as American Spinal Injury Association Impairment Scale (AIS) A to D were recruited...
August 31, 2016: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/27530131/reactive-oxygen-species-mediates-the-synergistic-activity-of-fenretinide-combined-with-the-microtubule-inhibitor-abt-751-against-multidrug-resistant-recurrent-neuroblastoma-xenografts
#5
Nancy E Chen, N Vanessa Maldonado, Vazgen Khankaldyyan, Hiroyuki Shimada, Michael M Song, Barry J Maurer, C Patrick Reynolds
ABT-751 is a colchicine-binding site microtubule inhibitor. Fenretinide (4-HPR) is a synthetic retinoid. Both agents have shown activity against neuroblastoma in laboratory models and clinical trials. We investigated the antitumor activity of 4-HPR + the microtubule-targeting agents ABT-751, vincristine, paclitaxel, vinorelbine, or colchicine in laboratory models of recurrent neuroblastoma. Drug cytotoxicity was assessed in vitro by a fluorescence-based assay (DIMSCAN) and in subcutaneous xenografts in nu/nu mice...
August 16, 2016: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/27496695/how-have-research-questions-and-methods-used-in-clinical-trials-published-in-clinical-rehabilitation-changed-over-the-last-30%C3%A2-years
#6
Nancy E Mayo, Navaldeep Kaur, Skye P Barbic, Julio Fiore, Ruth Barclay, Lois Finch, Ayse Kuspinar, Miho Asano, Sabrina Figueiredo, Ala' Sami Aburub, Fadi Alzoubi, Alaa Arafah, Sorayya Askari, Behtash Bakhshi, Vanessa Bouchard, Johanne Higgins, Stanley Hum, Mehmet Inceer, Marie Eve Letellier, Christiane Lourenco, Kedar Mate, Nancy M Salbach, Carolina Moriello
Research in rehabilitation has grown from a rare phenomenon to a mature science and clinical trials are now common. The purpose of this study is to estimate the extent to which questions posed and methods applied in clinical trials published in Clinical Rehabilitation have evolved over three decades with respect to accepted standards of scientific rigour. Studies were identified by journal, database, and hand searching for the years 1986 to 2016.A total of 390 articles whose titles suggested a clinical trial of an intervention, with or without randomization to form groups, were reviewed...
September 2016: Clinical Rehabilitation
https://www.readbyqxmd.com/read/27443740/replication-fork-stability-confers-chemoresistance-in-brca-deficient-cells
#7
Arnab Ray Chaudhuri, Elsa Callen, Xia Ding, Ewa Gogola, Alexandra A Duarte, Ji-Eun Lee, Nancy Wong, Vanessa Lafarga, Jennifer A Calvo, Nicholas J Panzarino, Sam John, Amanda Day, Anna Vidal Crespo, Binghui Shen, Linda M Starnes, Julian R de Ruiter, Jeremy A Daniel, Panagiotis A Konstantinopoulos, David Cortez, Sharon B Cantor, Oscar Fernandez-Capetillo, Kai Ge, Jos Jonkers, Sven Rottenberg, Shyam K Sharan, André Nussenzweig
Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-strand breaks by homologous recombination and consequently are hypersensitive to DNA-damaging agents, including cisplatin and poly(ADP-ribose) polymerase (PARP) inhibitors. Here we show that loss of the MLL3/4 complex protein, PTIP, protects Brca1/2-deficient cells from DNA damage and rescues the lethality of Brca2-deficient embryonic stem cells. However, PTIP deficiency does not restore homologous recombination activity at double-strand breaks...
July 20, 2016: Nature
https://www.readbyqxmd.com/read/27401492/enrolling-and-keeping-participants-in-multiple-sclerosis-self-management-interventions-a-systematic-review-and-meta-analysis
#8
Alaa M Arafah, Vanessa Bouchard, Nancy E Mayo
OBJECTIVES: The objectives were to provide an estimate of expected enrolment and attrition rates based on published studies of existing self-management interventions for people with multiple sclerosis, and to identify contributing factors and impact on outcomes. REVIEW METHODS: A systematic literature search was conducted using Ovid MEDLINE, PsychINFO, EMBASE, AMED, CINAHL, OT Seeker, PubMed, and the Cochrane Database of Systematic Reviews databases. Controlled trials with or without randomization using either a between-group or within-person design were included if they met specified criteria...
July 8, 2016: Clinical Rehabilitation
https://www.readbyqxmd.com/read/27348065/the-influence-of-patient-readiness-on-implementation-of-evidence-based-ptsd-treatments-in-veterans-affairs-residential-programs
#9
Joan M Cook, Vanessa Simiola, Jessica L Hamblen, Nancy Bernardy, Paula P Schnurr
OBJECTIVE: Mental health provider perceptions of patient readiness for trauma-focused evidence-based treatments (EBTs) for posttraumatic stress disorder (PTSD) have been found to impact outpatient care in the Department of Veterans Affairs (VA). METHOD: One hundred and 72 mental health directors and providers from 36 VA residential PTSD treatment programs completed qualitative interviews regarding implementation of two EBTs, Prolonged Exposure (PE), and Cognitive Processing Therapy (CPT)...
June 27, 2016: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/27316915/french-intensive-care-society-international-congress-r%C3%A3-animation-2016
#10
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27278776/erosive-potential-of-vitamin-and-vitamin-mineral-effervescent-tablets
#11
COMPARATIVE STUDY
Florian J Wegehaupt, Nancy Lunghi, Vanessa M G Hogger, Thomas Attin
The extrinsic sources for erosion-causing acids are primarily acidic beverages and foodstuffs. Effervescent tablets also contain organic acids (e.g. citric, tartaric, malic) in order to form carbon dioxide by contact with water – with the help of the carbonate salts of the tablets. To adequately inform patients about the possible erosive potential of effervescent tablets, this study was undertaken in order to investigate the erosive potential of effervescent tablets (ET), containing either a combination of vitamins and minerals or vitamins only, commercially available in Switzerland...
2016: Swiss Dental Journal
https://www.readbyqxmd.com/read/27255082/the-global-network-antenatal-corticosteroids-trial-impact-on-stillbirth
#12
Robert L Goldenberg, Vanessa R Thorsten, Fernando Althabe, Sarah Saleem, Ana Garces, Waldemar A Carlo, Omrana Pasha, Elwyn Chomba, Shivaprasad Goudar, Fabian Esamai, Nancy F Krebs, Richard J Derman, Edward A Liechty, Archana Patel, Patricia L Hibberd, Pierre M Buekens, Marion Koso-Thomas, Menachem Miodovnik, Alan H Jobe, Dennis D Wallace, José M Belizán, Elizabeth M McClure
BACKGROUND: Antenatal corticosteroids are commonly used to reduce neonatal mortality, but most research to date has been in high-resource settings and few studies have evaluated its impact on stillbirth. In the Antenatal Corticosteroids Trial (ACT), a multi-country trial to assess impact of a multi-faceted intervention including antenatal corticosteroids to reduce neonatal mortality associated with preterm birth, we found an overall increase in 28-day neonatal mortality and stillbirth associated with the intervention...
June 2, 2016: Reproductive Health
https://www.readbyqxmd.com/read/27228986/use-of-antenatal-corticosteroids-at-health-facilities-and-communities-in-low-and-middle-income-countries
#13
Mabel Berrueta, Jennifer Hemingway-Foday, Vanessa R Thorsten, Robert L Goldenberg, Waldemar A Carlo, Ana Garces, Archana Patel, Sarah Saleem, Omrana Pasha, Elwyn Chomba, Patricia L Hibberd, Nancy F Krebs, Shivaprasad Goudar, Richard J Derman, Fabian Esamai, Edward A Liechty, Janet L Moore, Elizabeth M McClure, Marion Koso-Thomas, Pierre M Buekens, José M Belizán, Fernando Althabe
BACKGROUND: Antenatal corticosteroids (ACS) for women at high risk of preterm birth is an effective intervention to reduce neonatal mortality among preterm babies delivered in hospital settings, but has not been widely used in low-middle resource settings. We sought to assess the rates of ACS use at all levels of health care in low and middle income countries (LMIC). METHODS: We assessed rates of ACS in 7 sites in 6 LMIC participating in the Eunice Kennedy Shriver National Institute of Child Health and Human Development's Global Network for Women and Children's Health Research Antenatal Corticosteroids Trial (ACT), a cluster-randomized trial to assess the feasibility, effectiveness, and safety of a multifaceted intervention designed to increase the use of ACS...
May 27, 2016: Reproductive Health
https://www.readbyqxmd.com/read/27221319/the-antenatal-corticosteroids-trial-act-a-secondary-analysis-to-explore-site-differences-in-a-multi-country-trial
#14
Karen Klein, Elizabeth M McClure, Daniela Colaci, Vanessa Thorsten, Patricia L Hibberd, Fabian Esamai, Ana Garces, Archana Patel, Sarah Saleem, Omrana Pasha, Elwyn Chomba, Waldemar A Carlo, Nancy F Krebs, Shivaprasad Goudar, Richard J Derman, Edward A Liechty, Marion Koso-Thomas, Pierre M Buekens, José M Belizán, Robert L Goldenberg, Fernando Althabe
BACKGROUND: The Antenatal Corticosteroid Trial (ACT) assessed the feasibility, effectiveness, and safety of a multifaceted intervention to increase the use of antenatal corticosteroids (ACS) in mothers at risk of preterm birth at all levels of care in low and middle-income countries. The intervention effectively increased the use of ACS but had no overall impact on neonatal mortality in the targeted <5(th) percentile birth weight infants. Being in the intervention clusters was also associated with an overall increase in neonatal deaths...
May 24, 2016: Reproductive Health
https://www.readbyqxmd.com/read/27221237/a-multi-faceted-intervention-including-antenatal-corticosteroids-to-reduce-neonatal-mortality-associated-with-preterm-birth-a-case-study-from-the-guatemalan-western-highlands
#15
Ana Garces, Elizabeth M McClure, Lester Figueroa, Sayury Pineda, K Michael Hambidge, Nancy F Krebs, Vanessa R Thorsten, Dennis D Wallace, Fernando Althabe, Robert L Goldenberg
BACKGROUND: The Global Network for Women's and Children's Health Research undertook a cluster-randomized trial to assess the impact of a multi-faceted intervention to identify women at high-risk of preterm birth at all levels of care, to administer corticosteroids to women and refer for facility delivery compared with standard care. Of the seven sites that participated in the ACT trial, only two sites had statistically significant reductions in the neonatal mortality among the target group of <5th percentile infants, and of the two, Guatemala's improvement in neonatal mortality was by far the largest...
May 24, 2016: Reproductive Health
https://www.readbyqxmd.com/read/27220987/the-antenatal-corticosteroids-trial-act-s-explanations-for-neonatal-mortality-a-secondary-analysis
#16
Fernando Althabe, Vanessa Thorsten, Karen Klein, Elizabeth M McClure, Patricia L Hibberd, Robert L Goldenberg, Waldemar A Carlo, Ana Garces, Archana Patel, Omrana Pasha, Elwyn Chomba, Nancy F Krebs, Shivaprasad Goudar, Richard J Derman, Fabian Esamai, Edward A Liechty, Nellie I Hansen, Sreelatha Meleth, Dennis D Wallace, Marion Koso-Thomas, Alan H Jobe, Pierre M Buekens, José M Belizán
BACKGROUND: The Antenatal Corticosteroid Trial assessed the feasibility, effectiveness, and safety of a multifaceted intervention to increase the use of antenatal corticosteroids (ACS) in mothers at risk of preterm birth at all levels of care in low and middle-income countries. The intervention effectively increased the use of ACS but was associated with an overall increase in neonatal deaths. We aimed to explore plausible pathways through which this intervention increased neonatal mortality...
2016: Reproductive Health
https://www.readbyqxmd.com/read/27134579/development-of-a-bilingual-ms-specific-health-classification-system-the-preference-based-multiple-sclerosis-index
#17
Ayse Kuspinar, Vanessa Bouchard, Carolina Moriello, Nancy E Mayo
OBJECTIVE: The global aim of this study was to contribute to the development of the Preference-Based Multiple Sclerosis Index (PBMSI). The specific objective of this foundational work was to qualitatively review the items selected for inclusion in the PBMSI using expert and patient feedback. METHODS: Cognitive interviews were conducted with patients with multiple sclerosis (MS) in English and French. The verbal probing method was used to conduct the interviews. For each PBMSI item, the interviewer probed for specific information on what types of difficulty participants had with the item and the basis for their response for each item...
March 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27128207/patients-with-coeliac-disease-reported-highter-consumption-of-added-sugar-and-total-fat-than-healthy-individuals
#18
Nancy Babio, Mireia Alcázar, Gemma Castillejo, Miriam Recasens, Francesc Martínez-Cerezo, Vanessa Gutiérrez-Pensado, Guiomar Masip, Cristina Vaqué, Anna Vila-Martí, Miriam Torres-Moreno, Enric Sánchez, Jordi Salas-Salvadó
OBJECTIVES: To compare the dietary pattern between subjects with coeliac disease (CD) (cases) and subjects without (healthy controls). METHODS: A case-control design study was conducted. A total of 98 subjects with CD (aged 10 to 23 years-old) were matched by age, gender and BMI with 98 non-coeliac participants. A non-consecutive 3-day food record was completed to assess energy, nutrient and food intake and evaluate the participant's adherence to recommendations...
April 26, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/26998834/early-short-term-treatment-with-neutralizing-human-monoclonal-antibodies-halts-shiv-infection-in-infant-macaques
#19
Ann J Hessell, J Pablo Jaworski, Erin Epson, Kenta Matsuda, Shilpi Pandey, Christoph Kahl, Jason Reed, William F Sutton, Katherine B Hammond, Tracy A Cheever, Philip T Barnette, Alfred W Legasse, Shannon Planer, Jeffrey J Stanton, Amarendra Pegu, Xuejun Chen, Keyun Wang, Don Siess, David Burke, Byung S Park, Michael K Axthelm, Anne Lewis, Vanessa M Hirsch, Barney S Graham, John R Mascola, Jonah B Sacha, Nancy L Haigwood
Prevention of mother-to-child transmission (MTCT) of HIV remains a major objective where antenatal care is not readily accessible. We tested HIV-1-specific human neutralizing monoclonal antibodies (NmAbs) as a post-exposure therapy in an infant macaque model for intrapartum MTCT. One-month-old rhesus macaques were inoculated orally with the simian-human immunodeficiency virus SHIVSF162P3. On days 1, 4, 7 and 10 after virus exposure, we injected animals subcutaneously with NmAbs and quantified systemic distribution of NmAbs in multiple tissues within 24 h after antibody administration...
April 2016: Nature Medicine
https://www.readbyqxmd.com/read/26954689/safety-profile-of-the-10-valent-pneumococcal-non-typeable-haemophilus-influenzae-protein-d-conjugate-vaccine-phid-cv
#20
Sven Arne Silfverdal, Vanessa Coremans, Nancy François, Dorota Borys, Jan Cleerbout
Safety and reactogenicity data were reviewed following 10 years of experience with the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) in clinical development and from post-licensure settings. Analyses of pooled clinical trial data and post-marketing reports provided an overview of its safety profile and allowed assessment of rare adverse events that might not have been identified previously. The safety of PHiD-CV was also evaluated in children at higher risk for pneumococcal infection (preterm and HIV-infected or HIV-exposed infants), for different vaccination schedules and co-administered pediatric vaccines, and with a focus on special categories of adverse events (febrile convulsions, apnea, Kawasaki disease and sudden deaths)...
March 8, 2016: Expert Review of Vaccines
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