keyword
MENU ▼
Read by QxMD icon Read
search

Lead

keyword
https://www.readbyqxmd.com/read/28931237/histone-methyltransferase-set8-epigenetically-reprograms-host-immune-responses-to-assist-mycobacterial-survival
#1
Vikas Singh, Praveen Prakhar, R S Rajmani, Kasturi Mahadik, Salik Miskat Borbora, Kithiganahalli Narayanaswamy Balaji
NQO1 and TRXR1 are important host reductases implicated in the regulation of inflammation and apoptosis. Although the transcriptional machinery governing these processes have been extensively investigated, the associated epigenetic regulatory events remain unclear. Here, we report that SET8, a histone H4 lysine 20 monomethylase (H4K20me1), is highly induced during Mycobacterium tuberculosis infection that orchestrates immune evasion strategies through the induction of NQO1 and TRXR1 in vivo. SET8, along with FoxO3a, mediates an active NQO1-PGC1-α complex, which promotes the anti-inflammatory M2 macrophage phenotype, and assists TRXR1-regulated arrest of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis...
August 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28931216/emergence-of-oseltamivir-resistant-h7n9-influenza-viruses-in-immunosuppressed-cynomolgus-macaques
#2
Maki Kiso, Kiyoko Iwatsuki-Horimoto, Seiya Yamayoshi, Ryuta Uraki, Mutsumi Ito, Noriko Nakajima, Shinya Yamada, Masaki Imai, Eiryo Kawakami, Yuriko Tomita, Satoshi Fukuyama, Yasushi Itoh, Kazumasa Ogasawara, Tiago J S Lopes, Tokiko Watanabe, Louise H Moncla, Hideki Hasegawa, Thomas C Friedrich, Gabriele Neumann, Yoshihiro Kawaoka
Antiviral compounds (eg, the neuraminidase inhibitor oseltamivir) are invaluable for the treatment of individuals infected with influenza A viruses of the H7N9 subtype (A[H7N9]), which have infected and killed hundreds of persons. However, oseltamivir treatment often leads to the emergence of resistant viruses in immunocompromised individuals. To better understand the emergence and properties of oseltamivir-resistant A(H7N9) viruses in immunosuppressed individuals, we infected immunosuppressed cynomolgus macaques with an A(H7N9) virus and treated them with oseltamivir...
September 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28931215/berberine-could-inhibit-thyroid-carcinoma-cells-by-inducing-mitochondrial-apoptosis-g0-g1-cell-cycle-arrest-and-suppressing-migration-via-pi3k-akt-and-mapk-signaling-pathways
#3
Liang Li, Xingchun Wang, Rampersad Sharvan, Jingyang Gao, Shen Qu
Berberine, an important natural isoquinoline alkaloid from traditional Chinese medicine, is reported to exhibit multiple pharmacological properties, including anti-microbial, anti-diabetes, anti-obesity, anti-inflammatory and anti-carcinogenic activities. Although studies have shown that a wide range of carcinoma cells could be inhibited by berberine, few studies involved thyroid carcinoma. We therefore examined the effect of berberine on papillary thyroid carcinoma (PTC, the most common subtype) and anaplastic thyroid carcinoma (ATC, the most malignant and aggressive subtype)...
September 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28931214/baicalin-alleviates-radiation-induced-epithelial-mesenchymal-transition-of-primary-type-ii-alveolar-epithelial-cells-via-tgf-%C3%AE-and-erk-gsk3%C3%AE-signaling-pathways
#4
Jinhua Lu, Yazhen Zhong, Zechen Lin, Xianlei Lin, Zhaohui Chen, Xuping Wu, Nan Wang, Haiqiao Zhang, Siyu Huang, Yuan Zhu, Yuanyuan Wang, Shengyou Lin
BACKGROUND: Radiation therapy is commonly used to treat thoracic malignancies. However, it may lead to severe lung pneumonitis and ultimately fibrosis. Irradiation has been reported to increase epithelial-mesenchymal transition (EMT) of type II alveolar epithelial cells (AEC), which play an important role in pulmonary fibrosis. The transforming growth factor-β (TGF-β) and ERK/glycogen synthase kinase 3β (GSK3β) pathways are critically involved in radiation-induced EMT. In the present study, we investigated whether baicalin was a novel therapeutic candidate for radiation-induced EMT in type II AEC...
September 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28931182/-primary-open-angle-glaucoma
#5
Esther M Hoffmann, Verena Prokosch-Willing
Glaucoma leads to blindness but there are diagnostic and therapeutic developments that aid ophthalmologists in the improved mangement of the disease compared to the past. Known risk factors such as age, myopia, dark pigmented skin, genetics, and elevated intraocular pressure play an important role for the individual patient's prognosis, and many yet unknown or not sufficiently investigated risk factors come along. The structured examination of the optic nerve head is crucial for the clincial diagnosis by the ophthalmologist...
September 20, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28931173/hopping-and-landing-performance-in-male-youth-soccer-players-effects-of-age-and-maturation
#6
Paul James Read, Jon L Oliver, Gregory Myer, Mark De Ste Croix, Rhodri Lloyd
Quantifying hopping and landing performances can assist coaches in identifying young male soccer players who may be at increased risk of injury. The influence of chronological age and maturation on these measures in this population is unknown. Single leg hop for distance (SLHD) and 75% horizontal hop and stick landing force (75%Hop) were examined in a cross-sectional sample (N=400) of elite male youth soccer players. Between-group differences for both chronological age (U11-U18) and stage of maturation (pre-, circa- or post-peak height velocity (PHV)) were analyzed...
September 20, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28931157/is-nocturnal-foraging-in-a-tropical-bee-an-escape-from-interference-competition
#7
Adam R Smith, Shannon M Kitchen, Ryan M Toney, Christian Ziegler
Temporal niche partitioning may result from interference competition if animals shift their activity patterns to avoid aggressive competitors. If doing so also shifts food sources, it is difficult to distinguish the effects of interference and consumptive competition in selecting for temporal niche shift. Bees compete for pollen and nectar from flowers through both interference and consumptive competition, and some species of bees have evolved nocturnality. Here, we use tropical forest canopy towers to observe bees (the night-flying sweat bees Megalopta genalis and M...
January 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28931125/patients-with-mental-problems-the-most-defenseless-travellers
#8
Peter Felkai, Tamas Kurimay
Background: Severe mental illness occurring abroad is a difficult situation for patients, their families, and for the local medical community. Patients with mental problem are doublely stigmatized due to their mental illness and because they are foreigners in an unfamiliar country. The appropriate treatment is often delayed, while patients are often dealt with in a manner that violates their human rights. Moreover, repatriation - which is vital in this case - is often delayed due to the lack of international protocols for the transportation and treatment of mentally ill travelers...
September 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28931091/mt-cell-responses-targeting-hiv-nef-uniquely-correlate-with-infected-cell-frequencies-after-long-term-antiretroviral-therapy
#9
Allison S Thomas, Kimberley L Jones, Rajesh T Gandhi, Deborah K McMahon, Joshua C Cyktor, Dora Chan, Szu-Han Huang, Ronald Truong, Alberto Bosque, Amanda B Macedo, Colin Kovacs, Erika Benko, Joseph J Eron, Ronald J Bosch, Christina M Lalama, Samuel Simmens, Bruce D Walker, John W Mellors, R Brad Jones
HIV-specific CD8+ T-cell responses limit viral replication in untreated infection. After the initiation of antiretroviral therapy (ART), these responses decay and the infected cell population that remains is commonly considered to be invisible to T-cells. We hypothesized that HIV antigen recognition may persist in ART-treated individuals due to low-level or episodic protein expression. We posited that if persistent recognition were occurring it would be preferentially directed against the early HIV gene products Nef, Tat, and Rev as compared to late gene products, such as Gag, Pol, and Env, which have higher barriers to expression...
September 20, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28931076/ghrelin-mediated-inhibition-of-the-tsh-stimulated-function-of-differentiated-human-thyrocytes-ex-vivo
#10
Maria Barington, Marianne Møller Brorson, Jacob Hofman-Bang, Åse Krogh Rasmussen, Birgitte Holst, Ulla Feldt-Rasmussen
Ghrelin is a peptide hormone produced mainly in the gastrointestinal tract known to regulate several physiological functions including gut motility, adipose tissue accumulation and hunger sensation leading to increased bodyweight. Studies have found a correlation between the plasma levels of thyroid hormones and ghrelin, but an effect of ghrelin on the human thyroid has never been investigated even though ghrelin receptors are present in the thyroid. The present study shows a ghrelin-induced decrease in the thyroid-stimulating hormone (TSH)-induced production of thyroglobulin and mRNA expression of thyroperoxidase in a primary culture of human thyroid cells obtained from paranodular tissue...
2017: PloS One
https://www.readbyqxmd.com/read/28931065/chlamydomonas-fap265-is-a-tubulin-polymerization-promoting-protein-essential-for-flagellar-reassembly-and-hatching-of-daughter-cells-from-the-sporangium
#11
Damayanti Tammana, Trinadh Venkata Satish Tammana
Tubulin polymerization promoting proteins (TPPPs) belong to a family of neomorphic moon lighting proteins, involved in various physiological and pathological conditions. In physiological conditions, TPPPs play an important role in microtubule dynamics regulating mitotic spindle assembly and in turn cell proliferation. In pathological situations, TPPPs interact with α-synuclein and β-amyloid and promote their aggregation leading to Parkinson's disease and multiple system atrophy. Orthologs of TPPP family proteins were identified in ciliary proteomes from various organisms including Chlamydomonas but their role in ciliogenesis was not known...
2017: PloS One
https://www.readbyqxmd.com/read/28931061/binding-of-a-c-type-lectin-s-coiled-coil-domain-to-the-domeless-receptor-directly-activates-the-jak-stat-pathway-in-the-shrimp-immune-response-to-bacterial-infection
#12
Jie-Jie Sun, Jiang-Feng Lan, Xiao-Fan Zhao, Gerardo R Vasta, Jin-Xing Wang
C-type lectins (CTLs) are characterized by the presence of a C-type carbohydrate recognition domain (CTLD) that by recognizing microbial glycans, is responsible for their roles as pattern recognition receptors in the immune response to bacterial infection. In addition to the CTLD, however, some CTLs display additional domains that can carry out effector functions, such as the collagenous domain of the mannose-binding lectin. While in vertebrates, the mechanisms involved in these effector functions have been characterized in considerable detail, in invertebrates they remain poorly understood...
September 20, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28931059/whole-genome-sequencing-of-mutants-with-increased-resistance-against-the-two-peptide-bacteriocin-plantaricin-jk-reveals-a-putative-receptor-and-potential-docking-site
#13
Bie Ekblad, Jon Nissen-Meyer, Tom Kristensen
By whole-genome sequencing of resistant mutants, a putative receptor for plantaricin JK, a two-peptide bacteriocin produced by some Lactobacillus plantarum strains, was identified in Lactobacillus plantarum NCFB 965 and Weissella viridescens NCFB 1655. The receptors of the two species had 66% identical amino acid sequences and belong to the amino acid-polyamine-organocation (APC) transporter protein family. The resistant mutants contained point mutations in the protein-encoding gene resulting in either premature stop codons, leading to truncated versions of the protein, or single amino acid substitutions...
2017: PloS One
https://www.readbyqxmd.com/read/28931050/saxs-and-stability-studies-of-iron-induced-oligomers-of-bacterial-frataxin-cyay
#14
Mostafa Fekry, Wessen Alshokry, Przemysław Grela, Marek Tchórzewski, Eva-Christina Ahlgren, Christopher A Söderberg, Oleksandr Gakh, Grazia Isaya, Salam Al-Karadaghi
Frataxin is a highly conserved protein found in both prokaryotes and eukaryotes. It is involved in several central functions in cells, which include iron delivery to biochemical processes, such as heme synthesis, assembly of iron-sulfur clusters (ISC), storage of surplus iron in conditions of iron overload, and repair of ISC in aconitase. Frataxin from different organisms has been shown to undergo iron-dependent oligomerization. At least two different classes of oligomers, with different modes of oligomer packing and stabilization, have been identified...
2017: PloS One
https://www.readbyqxmd.com/read/28931048/mir-181a-decelerates-proliferation-in-cutaneous-squamous-cell-carcinoma-by-targeting-the-proto-oncogene-kras
#15
Johannes Neu, Piotr Jan Dziunycz, Andreas Dzung, Karine Lefort, Martin Falke, Rémy Denzler, Sandra Nicole Freiberger, Guergana Iotzova-Weiss, Aleksandar Kuzmanov, Mitchell Paul Levesque, Gian-Paolo Dotto, Günther Franz L Hofbauer
Cutaneous squamous cell carcinoma (SCC) is the second most common human skin cancer with a rapidly increasing incidence among the Caucasian population. Among the many regulators, responsible for cancer progression and growth, microRNAs (miRNA) are generally accepted as key players by now. In our current study we found that microRNA-181a (miR-181a) shows low abundance in SCC compared to normal epidermal skin. In vitro, miRNA downregulation in normal primary keratinocytes induced increased proliferation, while in vivo miR-181a downregulation in HaCaT normal keratinocytes showed tumor-like growth increase up to 50%...
2017: PloS One
https://www.readbyqxmd.com/read/28931041/lactobacillus-paracasei-feeding-improves-immune-control-of-influenza-infection-in-mice
#16
Nouria Belkacem, Nicolas Serafini, Richard Wheeler, Muriel Derrien, Lilia Boucinha, Aurélie Couesnon, Nadine Cerf-Bensussan, Ivo Gomperts Boneca, James P Di Santo, Muhamed-Kkeir Taha, Raphaëlle Bourdet-Sicard
Respiratory tract infections such as flu cause severe morbidity and mortality and are among the leading causes of death in children and adults worldwide. Commensal microbiota is critical for orchestrating tissue homeostasis and immunity in the intestine. Probiotics represent an interesting source of immune modulators and several clinical studies have addressed the potential beneficial effects of probiotics against respiratory infections. Therefore, we have investigated the mechanisms of protection conferred by L...
2017: PloS One
https://www.readbyqxmd.com/read/28931019/the-role-of-backward-cell-migration-in-two-hit-mutants-production-in-the-stem-cell-niche
#17
Audrey Bollas, Leili Shahriyari
It has been discovered that there are two stem cell groups in the intestinal crypts: central stem cells (CeSCs), which are at the very bottom of the crypt, and border stem cells (BSCs), which are located between CeSCs and transit amplifying cells (TAs). Moreover, backward cell migration from BSCs to CeSCs has been observed. Recently, a bi-compartmental stochastic model, which includes CeSCs and BSCs, has been developed to investigate the probability of two-hit mutant production in the stem cell niche. In this project, we improve this stochastic model by adding the probability of backward cell migration to the model...
2017: PloS One
https://www.readbyqxmd.com/read/28930996/assessment-of-the-anticoagulant-and-anti-inflammatory-properties-of-endothelial-cells-using-3d-cell-culture-and-non-anticoagulated-whole-blood
#18
Riccardo Sfriso, Anjan Bongoni, Yara Banz, Nikolai Klymiuk, Eckhard Wolf, Robert Rieben
In vivo, endothelial cells are crucial for the natural anticoagulation of circulating blood. Consequently, endothelial cell activation leads to blood coagulation. This phenomenon is observed in many clinical situations, like organ transplantation in the presence of pre-formed anti-donor antibodies, including xenotransplantation, as well as in ischemia/reperfusion injury. In order to reduce animal experimentation according to the 3R standards (reduction, replacement and refinement), in vitro models to study the effect of endothelial cell activation on blood coagulation would be highly desirable...
September 5, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28930989/demonstration-of-a-hyperlens-integrated-microscope-and-super-resolution-imaging
#19
Dasol Lee, Minkyung Kim, Sunae So, Inki Kim, Gwanho Yoon, Kyunghoon Kim, Junsuk Rho
The use of super-resolution imaging to overcome the diffraction limit of conventional microscopy has attracted the interest of researchers in biology and nanotechnology. Although near-field scanning microscopy and superlenses have improved the resolution in the near-field region, far-field imaging in real-time remains a significant challenge. Recently, the hyperlens, which magnifies and converts evanescent waves into propagating waves, has emerged as a novel approach to far-field imaging. Here, we report the fabrication of a spherical hyperlens composed of alternating silver (Ag) and titanium oxide (TiO2) thin layers...
September 8, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28930986/low-pressure-vapor-assisted-solution-process-for-tunable-band-gap-pinhole-free-methylammonium-lead-halide-perovskite-films
#20
Carolin M Sutter-Fella, Yanbo Li, Nicola Cefarin, Aya Buckley, Quynh Phuong Ngo, Ali Javey, Ian D Sharp, Francesca M Toma
Organo-lead halide perovskites have recently attracted great interest for potential applications in thin-film photovoltaics and optoelectronics. Herein, we present a protocol for the fabrication of this material via the low-pressure vapor assisted solution process (LP-VASP) method, which yields ~19% power conversion efficiency in planar heterojunction perovskite solar cells. First, we report the synthesis of methylammonium iodide (CH3NH3I) and methylammonium bromide (CH3NH3Br) from methylamine and the corresponding halide acid (HI or HBr)...
September 8, 2017: Journal of Visualized Experiments: JoVE
keyword
keyword
2628
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"