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https://www.readbyqxmd.com/read/28938739/sequence-variants-of-khdrbs1-as-high-penetrance-susceptibility-risks-for-primary-ovarian-insufficiency-by-mis-regulating-mrna-alternative-splicing
#1
Binbin Wang, Lin Li, Ying Zhu, Wei Zhang, Xi Wang, Beili Chen, Tengyan Li, Hong Pan, Jing Wang, Kehkooi Kee, Yunxia Cao
STUDY QUESTION: Does a novel heterozygous KHDRBS1 variant, identified using whole-exome sequencing (WES) in two patients with primary ovarian insufficiency (POI) in a pedigree, cause defects in mRNA alternative splicing? SUMMARY ANSWER: The heterozygous variant of KHDRBS1 was confirmed to cause defects in alternative splicing of many genes involved in DNA replication and repair. WHAT IS KNOWN ALREADY: Studies in mice revealed that Khdrbs1 deficient females are subfertile, which manifests as delayed sexual maturity and significantly reduced numbers of secondary and pre-antral follicles...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938486/the-two-populations-of-kisspeptin-neurons-are-involved-in-the-ram-induced-lh-pulsatile-secretion-and-lh-surge-in-anestrous-ewes
#2
C Fabre-Nys, J Cognié, L Dufourny, M S Ghenim, S Martinet, O Lasserre, D Lomet, R P Millar, S Ohkura, Y Suetomi
Exposure to a ram during spring stimulates luteinizing hormone (LH) secretion and can induce ovulation in sexually quiescent ewes ("ram effect"). Kisspeptins (Kiss) present in the arcuate nucleus (ARC) and the preoptic area (POA) are potent stimulators of LH secretion. Our aim was to investigate if Kiss neurons mediate the increase in LH secretion during the "ram effect". With double immunofluorescent detection we identified Kiss neurons (Kiss IR) activated (Fos IR) by exposure to a ram for 2h (M2), 12h (M12) or to ewes for 2h (C)...
September 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938464/sex-differences-in-steroid-receptor-co-expression-and-circadian-timed-activation-of-kisspeptin-and-rfrp-3-neurons-may-contribute-to-the-sexually-dimorphic-basis-of-the-lh-surge
#3
Matthew C Poling, Elena Y Luo, Alexander S Kauffman
In rodents, the ovulation-inducing LH surge is sexually dimorphic, occurring only in females, but the reasons for this sex difference are unclear. Two neuropeptides, kisspeptin and RFRP-3, are hypothesized to regulate the GnRH/LH surge. In females, both these systems show circadian changes coincident with the LH surge, but whether males show similar temporal changes under comparable hormonal conditions is unknown. Here, we evaluated circadian time (CT)-dependent changes in gene expression and neuronal activation of Kiss1 and Rfrp neurons of female and male mice given identical LH surge-inducing estrogen regimens...
August 9, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938437/progressive-fibrosis-a-progesterone-and-klf11-mediated-sexually-dimorphic-female-response
#4
Chandra C Shenoy, Zaraq Khan, Ye Zheng, Tiffanny L Jones, Khashayarsha Khazaie, Gaurang S Daftary
Progressive scarring is ubiquitous post-operatively and in an array of chronic systemic diseases. Recent studies indicate that such scarring has high female propensity; females are also almost exclusively affected by endometriosis, a common sex steroid dependent fibrotic disease. Endometriosis related fibrosis is regulated epigenetically through transcription factor Krüppel-like factor 11(KLF11). In response to surgical induction of endometriosis, Klf11-/- female mice develop significant fibrosis in contrast to wild-type mice...
August 11, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938423/igfbp4-is-required-for-adipogenesis-and-influences-the-distribution-of-adipose-depots
#5
David E Maridas, Victoria E DeMambro, Phuong T Le, Subburaman Mohan, Clifford J Rosen
Insulin-like Growth Factor I (IGF-I) induces adipogenesis in vitro. IGF Binding Protein 4 (IGFBP4) is highly expressed in adipocytes and osteoblasts and is inhibitory of IGFs in vitro. We previously reported that Igfbp4 null mice (Igfbp4-/-) had decreased fat proportions at 8 and 16 weeks of age. However, the mechanism leading to the reduced adiposity remains unknown. The purpose of this study was to elucidate how IGFBP4 mediates adipose tissue development in vivo. Our results showed that inguinal (iWAT) and gonadal (gWAT) white adipose tissues from Igfbp4-/- mice had decreased weights and Pparγ expression...
July 27, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938422/prepubertal-development-of-gonadotropin-releasing-hormone-gnrh-neuron-activity-is-altered-by-sex-age-and-prenatal-androgen-exposure
#6
Eden A Dulka, Suzanne M Moenter
Gonadotropin-releasing hormone (GnRH) neurons regulate reproduction though pulsatile hormone release. Disruption of GnRH release as measured via LH pulses occurs in polycystic ovary syndrome (PCOS), and in young hyperandrogenemic girls. In adult prenatally androgenized (PNA) mice, which exhibit many aspects of PCOS, increased LH is associated with increased GnRH neuron action potential firing. How GnRH neuron activity develops over the prepubertal period and whether or not this is altered by sex or prenatal androgen treatment are unknown...
September 15, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938228/sex-determination-from-chest-measurements-in-a-sample-of-egyptian-adults-using-multislice-computed-tomography
#7
Ragaa T Darwish, Manal H Abdel-Aziz, Abdel-Aziz M El Nekiedy, Zahraa K Sobh
BACKGROUND: In forensic sciences to determine one's sex is quite important during the identity defining stage. The reliability of sex determination depends on the completeness of the remains and the degree of sexual dimorphism inherent in the population. Computed Tomography is the imaging modality of choice for two- and three-dimensional documentation and analysis of many autopsy findings. OBJECTIVE: The aim of the present work was to assess the reliability of Three-dimensional Multislice Computed Tomography (3D MSCT) to determine sexual dimorphism from certain chest measurements; sternum and fourth rib using the 3D MSCT and to develop equations for sex determination from these bones among adult Egyptians sample...
September 11, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28938103/let-s-talk-about-sex-a-qualitative-study-exploring-the-experiences-of-hiv-nurses-when-discussing-sexual-risk-behaviours-with-hiv-positive-men-who-have-sex-with-men
#8
S de Munnik, C den Daas, H S M Ammerlaan, G Kok, M S Raethke, S C J M Vervoort
BACKGROUND: Despite prevention efforts, the incidence of sexually transmitted infection among HIV-positive men who have sex with men remains high, which is indicative of unchanged sexual risk behaviour. Discussing sexual risk behaviour has been shown to help prevent sexually transmitted infections among HIV-positive men who have sex with men. OBJECTIVES: The aim of this study was to identify factors that influence whether - and how - specialised HIV nurses discuss sexual risk behaviour with HIV-positive men who have sex with men...
September 6, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28937851/hpv-vaccine-acceptability-in-high-risk-greek-men
#9
Lea Hoefer, Savas Tsikis, George Bethimoutis, Electra Nicolaidou, Vassilios Paparizos, Christina Antoniou, Antonios Kanelleas, Leonidas Chardalias, Georgios-Emmanouil Stavropoulos, John Schneider, Angella Charnot-Katsikas
BACKGROUND: HPV is associated with malignancy in men, yet there is a lack of data on HPV knowledge, vaccine acceptability, and factors affecting vaccine acceptability in Greek men. This study aims to identify determinants of knowledge and willingness to vaccinate against HPV among high-risk Greek men. METHODS: Men (n = 298) between the ages of 18 and 55 were enrolled from the STI and HIV clinics at "Andreas Syggros" Hospital in Athens, Greece from July-October 2015...
September 22, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28937809/effects-of-clonal-reproduction-on-evolutionary-lag-and-evolutionary-rescue
#10
Maria E Orive, Michael Barfield, Carlos Fernandez, Robert D Holt
Evolutionary lag-the difference between mean and optimal phenotype in the current environment-is of keen interest in light of rapid environmental change. Many ecologically important organisms have life histories that include stage structure and both sexual and clonal reproduction, yet how stage structure and clonality interplay to govern a population's rate of evolution and evolutionary lag is unknown. Effects of clonal reproduction on mean phenotype partition into two portions: one that is phenotype dependent, and another that is genotype dependent...
October 2017: American Naturalist
https://www.readbyqxmd.com/read/28937503/patient-burden-of-axial-spondyloarthritis
#11
Vibeke Strand, Jasvinder A Singh
Axial spondyloarthritis (AxSpA) is an inflammatory spondyloarthritis (SpA) that has significant impact on a patient's life. Symptoms, including fatigue, sleep problems, depression, and sexual dysfunction, can profoundly impact health-related quality of life (HRQoL) and limit work, leisure, and daily activities. Available therapies effectively manage pain and inflammation in early-stage disease, but patients often continue to experience impaired HRQoL. Thus, there remains a need for new therapies with novel mechanisms that can stop disease progression, potentially reverse damage caused by AxSpA and improve HRQoL in patients with AxSpA...
September 21, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28937474/patient-burden-of-axial-spondyloarthritis
#12
Vibeke Strand, Jasvinder A Singh
Axial spondyloarthritis (AxSpA) is an inflammatory spondyloarthritis (SpA) that has significant impact on a patient's life. Symptoms, including fatigue, sleep problems, depression, and sexual dysfunction, can profoundly impact health-related quality of life (HRQoL) and limit work, leisure, and daily activities. Available therapies effectively manage pain and inflammation in early-stage disease, but patients often continue to experience impaired HRQoL. Thus, there remains a need for new therapies with novel mechanisms that can stop disease progression, potentially reverse damage caused by AxSpA and improve HRQoL in patients with AxSpA...
October 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28937408/editorial-sexual-disorders
#13
Antonio Pacheco Palha
No abstract text is available yet for this article.
September 20, 2017: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/28936925/gay-men-s-understanding-and-education-of-new-hiv-prevention-technologies-in-vancouver-canada
#14
Benjamin J Klassen, Nathan J Lachowsky, Sally Yue Lin, Joshua B Edward, Sarah A Chown, Robert S Hogg, David M Moore, Eric A Roth
Effective rollout of HIV treatment-based prevention such as pre-exposure prophylaxis and treatment as prevention has been hampered by poor education, limited acceptability, and stigma among gay men. We undertook a thematic analysis regarding the education sources and acceptability of these New Prevention Technologies (NPTs) using 15 semistructured interviews with gay men in Vancouver, Canada, who were early adopters of NPTs. NPT education was derived from a variety of sources, including the Internet, health care providers, community organizations, sexual partners, and peers; participants also emphasized their own capacities as learners and educators...
October 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/28936816/-effect-of-cognitive-behavioral-therapy-on-sexual-satisfaction-marital-adjustment-and-levels-of-depression-and-anxiety-symptoms-in-couples-with-vaginismus
#15
Cennet Şafak Öztürk, Haluk Arkar
OBJECTIVE: The aim of this study was to assess the effect of Cognitive Behavioral Therapy (CBT) on sexual functions of women with vaginismus and their husbands, their marital adjustment, and their levels of depression and anxiety symptoms. METHOD: Twenty-six couples diagnosed as vaginismus according to DSM-IV-TR diagnostic criteria in gynecology outpatient clinics of Izmir Ege Maternity Hospital and Gynecological Diseases Training and Research Hospital were included in the study...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/28936793/restricted-female-function-of-hermaphrodites-in-a-gynodioecious-shrub-daphne-jezoensis-thymelaeaceae
#16
Akari Shibata, Yoshiaki Kameyama, Gaku Kudo
Gynodioecy is the coexistence of hermaphrodites and females in a population. It is supposed to be an intermediate stage in the evolutionary pathway from hermaphroditism to dioecy in angiosperm. Hermaphrodites gain fitness through both seed and pollen production whereas females gain fitness only through seed production. As females spread in a gynodioecious population, sexual selection prompts hermaphrodites to invest in male function and male-biased hermaphrodites prevail. In the gynodioecious shrub Daphne jezoensis (Thymelaeaceae), female frequency is stably around 50% in most populations, and fruit-set rate of hermaphrodites is commonly low...
September 21, 2017: Journal of Plant Research
https://www.readbyqxmd.com/read/28936726/pornography-use-and-marital-separation-evidence-from-two-wave-panel-data
#17
Samuel L Perry
As pornography use continues to increase in the U.S., studies have sought to understand its potential influence on marital relationships. Yet, the primary focus of such studies has been pornography's association with marital quality, not stability. Consequently, we still know relatively little about whether pornography consumption at one time predicts marital disruption later on. Drawing on data from the 2006 and 2012 waves of the nationally representative Portraits of American Life Study (N = 445), this article examined whether married Americans who viewed pornography in 2006, either at all or in greater frequencies, were more likely to experience a marital separation by 2012...
September 21, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28936655/immunolocalization-of-agps-and-pectins-in-quercus-suber-gametophytic-structures
#18
Mário Luís da Costa, Ana Lúcia Lopes, Maria Isabel Amorim, Sílvia Coimbra
The arabinogalactan proteins (AGPs) are highly glycosylated proteins, ubiquitous in plants that have been linked to numerous aspects of sexual reproduction in several plant species, including the monoecious tree species Quercus suber. AGPs are found in cell membranes and cell walls of all types of tissues, including reproductive cells and organs. Pectins are cell wall components that also have been shown to change in composition and quantity during the maturations of the male and female gametophyte in cork oak...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28936653/live-cell-imaging-of-auxin-and-cytokinin-signaling-in-maize-female-gametophytes
#19
Antony M Chettoor, Matthew M S Evans
The plant life cycle is characterized by the alternation of generations between genetically active diploid sporophytes and haploid gametophytes. The gametophytes of flowering plants are sexually dimorphic. While the male gametophyte consists of only three cells (two sperm and a vegetative cell) and is released by the parent sporophyte, the female gametophyte (or embryo sac) is more complex and remains imbedded within diploid sporophyte tissues. In maize, the female gametophyte is embedded in a large ovule surrounded with multiple nucellar cell layers impeding live-cell imaging approaches to study embryo sac functions...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28936648/live-cell-imaging-of-f-actin-dynamics-during-fertilization-in-arabidopsis-thaliana
#20
Daichi Susaki, Daisuke Maruyama, Ramesh Yelagandula, Frederic Berger, Tomokazu Kawashima
Fertilization comprises a complex series of cellular processes leading to the fusion of a male and female gamete. Many studies have been carried out to investigate each step of fertilization in plants; however, our comprehensive understanding of all the sequential events during fertilization is still limited. This is largely due to difficulty in investigating events in the female gametophyte, which is deeply embedded in the maternal tissue. Recent advances in confocal microcopy assisted by fluorescent marker lines have contributed to visualizing subcellular dynamics in real time during fertilization in vivo...
2017: Methods in Molecular Biology
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