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olfactory memory

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https://www.readbyqxmd.com/read/29166600/dopamine-receptor-damb-signals-via-gq-to-mediate-forgetting-in-drosophila
#1
Sophie Himmelreich, Ikuo Masuho, Jacob A Berry, Courtney MacMullen, Nickolas K Skamangas, Kirill A Martemyanov, Ronald L Davis
Prior studies have shown that aversive olfactory memory is acquired by dopamine acting on a specific receptor, dDA1, expressed by mushroom body neurons. Active forgetting is mediated by dopamine acting on another receptor, Damb, expressed by the same neurons. Surprisingly, prior studies have shown that both receptors stimulate cyclic AMP (cAMP) accumulation, presenting an enigma of how mushroom body neurons distinguish between acquisition and forgetting signals. Here, we surveyed the spectrum of G protein coupling of dDA1 and Damb, and we confirmed that both receptors can couple to Gs to stimulate cAMP synthesis...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29155265/neuroanatomical-distribution-and-function-of-the-vasopressin-v1b-receptor-in-the-rat-brain-deciphered-using-specific-fluorescent-ligands
#2
Maithé Corbani, Rafik Marir, Miguel Trueba, Magda Chafai, Anne Vincent, Amélie M Borie, Michel G Desarménien, Yoichi Ueta, Csaba Tomboly, Aleksandra Olma, Maurice Manning, Gilles Guillon
It is now accepted that vasopressin, through V1A/V1B receptors, centrally regulates cognitive functions such as memory, affiliation, stress, fear and depression. However, the respective roles of these receptor isoforms and their contribution to stress-related pathologies remain uncertain. The development of new therapeutic treatments requires a precise knowledge of the distribution of these receptors within the brain, which has been so far hampered by the lack of selective V1B markers. In the present study, we have determined the pharmacological properties of three new potent rat V1B fluorescent ligands and demonstrated that they constitute valuable tools for simultaneous visualization and activation of native V1B receptors in living rat brain tissue...
November 16, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29121272/chronic-cigarette-smoking-associates-directly-and-indirectly-with-self-reported-olfactory-alterations-analysis-of-the-2011-2014-national-health-and-nutrition-examination-survey-nhanes
#3
Sarah-Grace Glennon, Tania Huedo-Medina, Shristi Rawal, Howard J Hoffman, Mark D Litt, Valerie B Duffy
Introduction: Population-based studies show inconsistent effects of cigarette smoking on olfactory function. We aimed to identify direct and indirect associations between measures of smoking exposure/nicotine dependence and altered olfaction in a nationally-representative sample of adults. Methods: NHANES 2011-2014 (n=7,418) participants (mean age=57.8±12.2 years) self-reported olfaction and related health and demographic risks. Affirmative answers to three questions defined altered olfaction (olfactory problems in past year; worse ability since age 25; phantom smells)...
November 7, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29120562/be-vigilant-for-dementia-in-parkinson%C3%A2-s-disease
#4
Flavia Niccolini, Konstantinos Diamantopoulos, Stelios Kiosses, Marios Politis
It is estimated that up to 80% of patients with Parkinson's disease will eventually develop cognitive impairment over the course of their illness. Even at the time of diagnosis, cognitive impairment has been reported in 20-25% of patients. Commonly affected cognitive domains are executive function, visuospatial ability and attention control. In addition, patients with Parkinson's disease dementia may present with deficits in language function and verbal memory. Psychosis may occur in approximately 40% of patients with Parkinson's disease, and is associated with an increased risk of developing cognitive impairment...
May 2017: Practitioner
https://www.readbyqxmd.com/read/29114209/the-biogenic-amine-tyramine-and-its-receptor-amtyr1-in-olfactory-neuropils-in-the-honey-bee-apis-mellifera-brain
#5
Irina T Sinakevitch, Sasha M Daskalova, Brian H Smith
This article describes the cellular sources for tyramine and the cellular targets of tyramine via the Tyramine Receptor 1 (AmTyr1) in the olfactory learning and memory neuropils of the honey bee brain. Clusters of approximately 160 tyramine immunoreactive neurons are the source of tyraminergic fibers with small varicosities in the optic lobes, antennal lobes, lateral protocerebrum, mushroom body (calyces and gamma lobes), tritocerebrum and subesophageal ganglion (SEG). Our tyramine mapping study shows that the primary sources of tyramine in the antennal lobe and calyx of the mushroom body are from at least two Ventral Unpaired Median neurons (VUMmd and VUMmx) with cell bodies in the SEG...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/29107547/camkii%C3%AE-expression-defines-two-functionally-distinct-populations-of-granule-cells-involved-in-different-types-of-odor-behavior
#6
Sarah Malvaut, Simona Gribaudo, Delphine Hardy, Linda Suzanne David, Laura Daroles, Simon Labrecque, Marie-Anne Lebel-Cormier, Zayna Chaker, Daniel Coté, Paul De Koninck, Martin Holzenberger, Alain Trembleau, Isabelle Caille, Armen Saghatelyan
Granule cells (GCs) in the olfactory bulb (OB) play an important role in odor information processing. Although they have been classified into various neurochemical subtypes, the functional roles of these subtypes remain unknown. We used in vivo two-photon Ca(2+) imaging combined with cell-type-specific identification of GCs in the mouse OB to examine whether functionally distinct GC subtypes exist in the bulbar network. We showed that half of GCs express Ca(2+)/calmodulin-dependent protein kinase IIα (CaMKIIα(+)) and that these neurons are preferentially activated by olfactory stimulation...
November 6, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29097760/task-correlated-cortical-asymmetry-and-intra-and-inter-hemispheric-separation
#7
Yaniv Cohen, Donald A Wilson
Cerebral lateralization is expressed at both the structural and functional levels, and can exist as either a stable characteristic or as a dynamic feature during behavior and development. The anatomically relatively simple olfactory system demonstrates lateralization in both human and non-human animals. Here, we explored functional lateralization in both primary olfactory cortex - a region critical for odor memory and perception- and orbitofrontal cortex (OFC) - a region involved in reversal learning- in rats performing an odor learning and reversal task...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29097202/distinct-amyloid-precursor-protein-processing-machineries-of-the-olfactory-system
#8
Jae Yeon Kim, Ameer Rasheed, Seung-Jun Yoo, So Yeun Kim, Bongki Cho, Gowoon Son, Seong-Woon Yu, Keun-A Chang, Yoo-Hun Suh, Cheil Moon
Processing of amyloid precursor protein (APP) occurs through sequential cleavages first by β-secretase and then by the γ-secretase complex. However, abnormal processing of APP leads to excessive production of β-amyloid (Aβ) in the central nervous system (CNS), an event which is regarded as a primary cause of Alzheimer's disease (AD). In particular, gene mutations of the γ-secretase complex-which contains presenilin 1 or 2 as the catalytic core-could trigger marked Aβ accumulation. Olfactory dysfunction usually occurs before the onset of typical AD-related symptoms (eg, memory loss or muscle retardation), suggesting that the olfactory system may be one of the most vulnerable regions to AD...
October 31, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29094304/perineuronal-nets-labeled-by-monoclonal-antibody-vc1-1-ensheath-interneurons-expressing-parvalbumin-and-calbindin-in-the-rat-amygdala
#9
Alexander J McDonald, Patricia G Hamilton, Colin J Barnstable
Perineuronal nets (PNNs) are specialized condensations of extracellular matrix that ensheath particular neuronal subpopulations in the brain and spinal cord. PNNs regulate synaptic plasticity, including the encoding of fear memories by the amygdala. The present immunohistochemical investigation studied PNN structure and distribution, as well as the neurochemistry of their ensheathed neurons, in the rat amygdala using monoclonal antibody VC1.1, which recognizes a glucuronic acid 3-sulfate glycan associated with PNNs in the cerebral cortex...
November 1, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29073044/smell-s-and-smell-r-olfactory-tests-not-influenced-by-odor-specific-insensitivity-or-prior-olfactory-experience
#10
Julien W Hsieh, Andreas Keller, Michele Wong, Rong-San Jiang, Leslie B Vosshall
Smell dysfunction is a common and underdiagnosed medical condition that can have serious consequences. It is also an early biomarker of neurodegenerative diseases, including Alzheimer's disease, where olfactory deficits precede detectable memory loss. Clinical tests that evaluate the sense of smell face two major challenges. First, human sensitivity to individual odorants varies significantly, so test results may be unreliable in people with low sensitivity to a test odorant but an otherwise normal sense of smell...
October 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29065290/olfactory-imprinting-a-worm-s-memory-of-things-past
#11
Merly C Vogt, Oliver Hobert
Exposure to distinct stimuli during critical periods of development can affect behavior long-term. A new study in Caenorhabditis elegans demonstrates that changes in neuronal activity of one synaptic connection following early-life pheromone exposure are sufficient to permanently enhance specific avoidance responses.
October 23, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29063117/-progress-in-multisensory-integration-during-self-motion-processing
#12
Ying-Ying Zhang, Dan-Qing Jiang, Sha-Sha Li, Pei-Ji Liang, Ai-Hua Chen
In the daily life, we perceive the world around us by integrating multiple sensory cues (visual, auditory, olfactory, gustatory, tactile, vestibular and proprioceptive) to create a coherent, reliable representation that allows us to interact meaningfully with the environment. The integration of different sensory information is necessary for our perception, motor transformation, decision making, learning and memory. In the past decades, many interdisciplinary researchers have been attracted to the field of multisensory research, and tremendous advances have been made in this field...
October 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/29040475/from-nose-to-memory-the-involuntary-nature-of-odor-evoked-autobiographical-memories-in-alzheimer-s-disease
#13
Mohamad El Haj, Marie Charlotte Gandolphe, Karim Gallouj, Dimitrios Kapogiannis, Pascal Antoine
Research suggests that odors may serve as a potent cue for autobiographical retrieval. We tested this hypothesis in Alzheimer's disease (AD) and investigated whether odor-evoked autobiographical memory is an involuntary process that shares similarities with music-evoked autobiographical memory. Participants with mild AD and controls were asked to retrieve two personal memories after odor exposure, after music exposure, and in an odor-and-music-free condition. AD participants showed better specificity, emotional experience, mental time travel, and retrieval time after odor and music exposure than in the control condition...
October 11, 2017: Chemical Senses
https://www.readbyqxmd.com/read/29029324/cadmium-exposure-impairs-cognition-and-olfactory-memory-in-male-c57bl-6-mice
#14
Hao Wang, Liang Zhang, Glen M Abel, Daniel R Storm, Zhengui Xia
Cadmium (Cd) is a heavy metal of high interest to the Superfund Initiative. Recent epidemiology studies have suggested a possible association between Cd exposure and cognitive as well as olfactory impairments in humans. However, studies in animal models are needed to establish a direct causal relationship between Cd exposure and impairments in cognition and olfaction. This study aims to investigate the toxic effect of Cd on cognition and olfactory function in mice. One group of 8-week old C57BL/6 male mice was exposed to 3 mg/L Cd (in the form of CdCl2) through drinking water for 20 weeks for behavior tests and final blood Cd concentration analysis...
September 25, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29017573/gad67-haploinsufficiency-reduces-amyloid-pathology-and-rescues-olfactory-memory-deficits-in-a-mouse-model-of-alzheimer-s-disease
#15
Yue Wang, Zheng Wu, Yu-Ting Bai, Gang-Yi Wu, Gong Chen
BACKGROUND: Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder, affecting millions of people worldwide. Although dysfunction of multiple neurotransmitter systems including cholinergic, glutamatergic and GABAergic systems has been associated with AD progression the underlying mechanisms remain elusive. We and others have recently found that GABA content is elevated in AD brains and linked to cognitive deficits in AD mouse models. The glutamic acid decarboxylase 67 (GAD67) is the major enzyme converting glutamate into GABA and has been implied in a number of neurological disorders such as epilepsy and schizophrenia...
October 10, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28984603/relation-of-odor-identification-with-alzheimer-s-disease-markers-in-cerebrospinal-fluid-and-cognition
#16
Babette L R Reijs, Inez H G B Ramakers, Lyzel Elias-Sonnenschein, Charlotte E Teunissen, Marleen Koel-Simmelink, Magda Tsolaki, Lars-Olof Wahlund, Gunhild Waldemar, Lucrezia Hausner, Peter Johannsen, Hugo Vanderstichele, Frans Verhey, D P Devanand, Pieter Jelle Visser
BACKGROUND: Impaired olfactory function is an early characteristic of Alzheimer's disease (AD), but it remains unclear if odor identification also relates to early markers of AD in cerebrospinal fluid (CSF). OBJECTIVE: To investigate the association between odor identification and amyloid-β 1-42 (Aβ42) and total tau (t-tau) concentrations in CSF. In addition, to examine the relation between odor identification and cognitive function at baseline and at follow-up, and whether these associations are moderated by CSF Aβ42 and t-tau and apolipoprotein E (APOE) genotype...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28969504/olfactory-cues-are-more-effective-than-visual-cues-in-experimentally-triggering-autobiographical-memories
#17
Maaike J de Bruijn, Michael Bender
Folk wisdom often refers to odours as potent triggers for autobiographical memory, akin to the Proust phenomenon that describes Proust's sudden recollection of a childhood memory when tasting a madeleine dipped into tea. Despite an increasing number of empirical studies on the effects of odours on cognition, conclusive evidence is still missing. We set out to examine the effectiveness of childhood and non-childhood odours as retrieval cues for autobiographical memories in a lab experiment. A total of 170 participants were presented with pilot-tested retrieval cues (either odours or images) to recall childhood memories and were then asked to rate the vividness, detail, and emotional intensity of these memories...
October 2, 2017: Memory
https://www.readbyqxmd.com/read/28968851/cognitive-load-alters-neuronal-processing-of-food-odors
#18
Sonja Maria Hoffmann-Hensel, Rik Sijben, Rea Rodriguez-Raecke, Jessica Freiherr
Obesity is a major health concern in modern societies. Although decreased physical activity and enhanced intake of high-caloric foods are important risk factors for developing obesity, human behavior during eating also plays a role. Previous studies have shown that distraction while eating increases food intake and leads to impaired processing of food stimuli. As olfaction is the most important sense involved in flavor perception, we used functional magnetic resonance imaging techniques to investigate the influence of cognitive memory load on olfactory perception and processing...
October 31, 2017: Chemical Senses
https://www.readbyqxmd.com/read/28968744/olfactory-context-dependent-memory-and-the-effects-of-affective-congruency
#19
Ryan P M Hackländer, Christina Bermeitinger
Odors have been claimed to be particularly effective mnemonic cues, possibly because of the strong links between olfaction and emotion processing. Indeed, past research has shown that odors can bias processing towards affectively congruent material. In order to determine whether this processing bias translates to memory, we conducted 2 olfactory-enhanced-context memory experiments where we manipulated affective congruency between the olfactory context and to-be-remembered material. Given the presumed importance of valence to olfactory perception, we hypothesized that memory would be best for affectively congruent material in the olfactory enhanced context groups...
October 31, 2017: Chemical Senses
https://www.readbyqxmd.com/read/28966266/nose-to-brain-delivery-of-peptide-drugs-enhanced-by-coadministration-of-cell-penetrating-peptides-therapeutic-potential-for-dementia
#20
Noriyasu Kamei
Recent reports suggest that peptide drugs such as insulin have the potential to serve as therapeutics in neurodegenerative diseases such as Alzheimer's disease. However, the transport of these drugs to the therapeutic target, the brain, is significantly hindered by the blood-brain barrier (BBB). Intranasal administration appears to be an ideal solution for drug delivery to the brain, bypassing the BBB, however the entry of peptide drugs into neuronal and epithelial cells in the olfactory mucosa remains low...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
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