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https://www.readbyqxmd.com/read/28720486/loss-of-synaptic-zinc-transport-in-progranulin-deficient-mice-may-contribute-to-progranulin-associated-psychopathology-and-chronic-pain
#1
Stefanie Hardt, Juliana Heidler, Boris Albuquerque, Lucie Valek, Christine Altmann, Annett Wilken-Schmitz, Michael K E Schäfer, Ilka Wittig, Irmgard Tegeder
Affective and cognitive processing of nociception contributes to the development of chronic pain and vice versa, pain may precipitate psychopathologic symptoms. We hypothesized a higher risk for the latter with immanent neurologic diseases and studied this potential interrelationship in progranulin-deficient mice, which are a model for frontotemporal dementia, a disease dominated by behavioral abnormalities in humans. Young naïve progranulin deficient mice behaved normal in tests of short-term memory, anxiety, depression and nociception, but after peripheral nerve injury, they showed attention-deficit and depression-like behavior, over-activity, loss of shelter-seeking, reduced impulse control and compulsive feeding behavior, which did not occur in equally injured controls...
July 15, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28715094/drosophila-mutants-lacking-octopamine-exhibit-impairment-in-aversive-olfactory-associative-learning
#2
Konstantin G Iliadi, Natalia Iliadi, Gabrielle L Boulianne
Octopamine is a biogenic amine in invertebrates that is considered a functional homolog of vertebrate norepinephrine, acting as a neurotransmitter, neuromodulator and neurohormone. Octopamine regulates many physiological processes such as metabolism, reproduction and different types of behaviour including learning and memory. Previous studies in insects led to the notion that acquisition of an olfactory memory depends on the octopaminergic system during appetitive (reward-based) learning, but not in the case of aversive (punishment-based) learning...
July 17, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28699082/combat-stress-decreases-memory-of-warfighters-in-action
#3
Rosa Delgado-Moreno, José Juan Robles-Pérez, Vicente Javier Clemente-Suárez
The present research aimed to analyze the effect of combat stress in the psychophysiological response and attention and memory of warfighters in a simulated combat situation. Variables of blood oxygen saturation, heart rate, blood glucose, blood lactate, body temperature, lower body muscular strength manifestation, cortical arousal, autonomic modulation, state anxiety and memory and attention through a postmission questionnaire were analyzed before and after a combat simulation in 20 male professional Spanish Army warfighters...
August 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28695538/fgf9-y162c-mutation-alters-information-processing-and-social-memory-in-mice
#4
Lillian Garrett, Lore Becker, Jan Rozman, Oliver Puk, Tobias Stoeger, Ali Önder Yildirim, Alexander Bohla, Oliver Eickelberg, Wolfgang Hans, Cornelia Prehn, Jerzy Adamski, Thomas Klopstock, Ildikó Rácz, Andreas Zimmer, Martin Klingenspor, Helmut Fuchs, Valerie Gailus-Durner, Wolfgang Wurst, Martin Hrabě de Angelis, Jochen Graw, Sabine M Hölter
In neuropsychiatric diseases, such as major depression and anxiety, pathogenic vulnerability is partially dictated by a genetic predisposition. The search continues to define this genetic susceptibility and establish new genetic elements as potential therapeutic targets. The fibroblast growth factors (FGFs) could be interesting in this regard. This family of signaling molecules plays important roles in development while also functioning within the adult. This includes effects on aspects of brain function such as neurogenesis and synapse formation...
July 10, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28686584/assessing-recent-and-remote-associative-olfactory-memory-in-rats-using-the-social-transmission-of-food-preference-paradigm
#5
Benjamin Bessières, Olivier Nicole, Bruno Bontempi
Rats have the ability to learn about potential food sources by sampling their odors on the breath of conspecifics. Although this ethologically based social behavior has been transposed to the laboratory to probe nonspatial associative olfactory memory, only a few studies have taken full advantage of its unique features to examine the organization of recently and remotely acquired information. We provide a set of standardized procedures and technical refinements that are particularly useful in achieving this goal while minimizing confounding factors...
July 2017: Nature Protocols
https://www.readbyqxmd.com/read/28683263/igf1-dependent-synaptic-plasticity-of-mitral-cells-in-olfactory-memory-during-social-learning
#6
Zhihui Liu, Zijun Chen, Congping Shang, Fei Yan, Yingchao Shi, Jiajing Zhang, Baole Qu, Hailin Han, Yanying Wang, Dapeng Li, Thomas C Südhof, Peng Cao
During social transmission of food preference (STFP), mice form long-term memory of food odors presented by a social partner. How does the brain associate a social context with odor signals to promote memory encoding? Here we show that odor exposure during STFP, but not unconditioned odor exposure, induces glomerulus-specific long-term potentiation (LTP) of synaptic strength selectively at the GABAergic component of dendrodendritic synapses of granule and mitral cells in the olfactory bulb. Conditional deletion of synaptotagmin-10, the Ca(2+) sensor for IGF1 secretion from mitral cells, or deletion of IGF1 receptor in the olfactory bulb prevented the socially relevant GABAergic LTP and impaired memory formation after STFP...
July 5, 2017: Neuron
https://www.readbyqxmd.com/read/28669782/the-drosophila-melanogaster-tribbles-pseudokinase-is-necessary-for-proper-memory-formation
#7
Holly LaFerriere, Troy Zars
The tribbles (trbl) pseudokinases play important roles in signaling and physiology in multiple contexts, ranging from innate immunity to cancer, suggesting fundamental cellular functions for the trbls' gene products. Despite expression of the trbl pseudokinases in the nervous systems of invertebrate and vertebrate animals, and evidence that they have a function within mouse and human dopamine neurons, there is no clear case for a function of a Trbl protein that influences behavior. Indeed, the first and only evidence for this type of function comes from Drosophila melanogaster, where a mutation of the single trbl gene was identified in a genetic screen for short-term memory mutant flies...
June 29, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28668282/brain-infusion-of-%C3%AE-synuclein-oligomers-induces-motor-and-non-motor-parkinson-s-disease-like-symptoms-in-mice
#8
Juliana T S Fortuna, Matthias Gralle, Danielle Beckman, Fernanda S Neves, Luan P Diniz, Paula S Frost, Fernanda Barros-Aragão, Luís E Santos, Rafaella A Gonçalves, Luciana Romão, Daniele C Zamberlan, Felix A A Soares, Carolina Braga, Debora Foguel, Flávia C A Gomes, Fernanda G De Felice, Sergio T Ferreira, Julia R Clarke, Cláudia P Figueiredo
Parkinson's disease (PD) is characterized by motor dysfunction, which is preceded by a number of non-motor symptoms including olfactory deficits. Aggregation of α-synuclein (α-syn) gives rise to Lewy bodies in dopaminergic neurons and is thought to play a central role in PD pathology. However, whether amyloid fibrils or soluble oligomers of α-syn are the main neurotoxic species in PD remains controversial. Here, we performed a single intracerebroventricular (i.c.v.) infusion of α-syn oligomers (α-SYOs) in mice and evaluated motor and non-motor symptoms...
June 29, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28664498/mice-exposure-to-tannery-effluents-changes-their-olfactory-capacity-and-their-response-to-predators-and-to-the-inhibitory-avoidance-test
#9
Bruna de Oliveira Mendes, Letícia Martins Rabelo, Bianca Costa E Silva, Joyce Moreira de Souza, André Luis da Silva Castro, Anderson Rodrigo da Silva, Aline Sueli de Lima Rodrigues, Guilherme Malafaia
The current study has assessed whether the oral and/or dermal exposure of C57Bl/6 J mice to tannery effluent (a complex pollutant consisting of xenobiotic mixtures) could damage their olfactory functions, as well as whether it changes their aversive behavior in the inhibitory avoidance test. Accordingly, the animals were distributed in groups which were exposed or not to this xenobiotic through two different routes (oral and dermal), for 15 days. The effluent group subjected to oral exposure received drinking water containing 5% tannery effluent, whereas the animals in the dermal group were exposed to raw tannery effluent for 1 h/day...
June 30, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28647598/functional-brain-networks-during-picture-encoding-and-recognition-in-different-odor-contexts
#10
J L Reichert, M Ninaus, W Schuehly, C Hirschmann, D Bagga, V Schöpf
Contextual odors can serve as retrieval cues when applied during encoding and recall/recognition of information. To investigate the neuronal basis of these observations, we collected functional MRI data while participants (n=51) performed an encoding and recognition memory task during which odors (congruent: CO or incongruent: IO) were presented as contextual cues. Recognition performance was not influenced by odor, but there was increased activation in the piriform cortex during successful encoding in the CO group, possibly indicating enhanced retrieval of information previously integrated with an olfactory percept...
June 21, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28645309/herpes-simplex-virus-1-infects-the-olfactory-bulb-shortly-following-ocular-infection-and-exhibits-a-long-term-inflammatory-profile-in-the-form-of-effector-and-hsv-1-specific-t-cells
#11
Chandra M Menendez, Daniel J J Carr
BACKGROUND: Herpes simplex virus 1 (HSV-1) infection can result in a life-threatening condition known as herpes simplex encephalitis (HSE). Trafficking patterns by which the virus reaches the central nervous system (CNS) following ocular infection are unresolved. We evaluated early viral dissemination pathways following ocular infection that involve trafficking to the olfactory bulb (OB). Additionally, we have characterized the capacity of HSV-1 to establish latency within OB tissue and profiled the local T lymphocyte response over the course of the acute infection into latency...
June 23, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28640825/olfactory-learning-without-the-mushroom-bodies-spiking-neural-network-models-of-the-honeybee-lateral-antennal-lobe-tract-reveal-its-capacities-in-odour-memory-tasks-of-varied-complexities
#12
HaDi MaBouDi, Hideaki Shimazaki, Martin Giurfa, Lars Chittka
The honeybee olfactory system is a well-established model for understanding functional mechanisms of learning and memory. Olfactory stimuli are first processed in the antennal lobe, and then transferred to the mushroom body and lateral horn through dual pathways termed medial and lateral antennal lobe tracts (m-ALT and l-ALT). Recent studies reported that honeybees can perform elemental learning by associating an odour with a reward signal even after lesions in m-ALT or blocking the mushroom bodies. To test the hypothesis that the lateral pathway (l-ALT) is sufficient for elemental learning, we modelled local computation within glomeruli in antennal lobes with axons of projection neurons connecting to a decision neuron (LHN) in the lateral horn...
June 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28634745/prolactin-function-and-putative-expression-in-the-brain
#13
REVIEW
Erika Alejandra Cabrera-Reyes, Ofelia Limón-Morales, Nadia Alejandra Rivero-Segura, Ignacio Camacho-Arroyo, Marco Cerbón
INTRODUCTION: Prolactin is a peptide hormone mainly synthetized and secreted by the anterior pituitary gland, but also by extrapituitary tissues, such as mammary gland, decidua, prostate, skin, and possibly the brain. Similarly, prolactin receptor is expressed in the pituitary gland, many peripheral tissues, and in contrast to prolactin, its receptor has been consistently detected in several brain regions, such as cerebral cortex, olfactory bulb, hypothalamus, hippocampus, amygdala, among others...
August 2017: Endocrine
https://www.readbyqxmd.com/read/28634675/wild-capuchin-monkeys-anticipate-the-amount-of-ripe-fruit-in-natural-trees
#14
María Paula Tujague, Charles H Janson
Tropical forests have a high diversity of tree species which have very low densities and vary across time in their seasons of peak fruiting and maturation rates. As evidence of the ability of primates to track or anticipate changes in fruit production at individual trees, researchers have used the increased speed of primate groups toward more rewarding food patches. We analyzed the speed of approach to natural trees of wild capuchin monkeys under the effect of scramble competition, after excluding any plausible visual, olfactory and auditory cues...
June 20, 2017: Animal Cognition
https://www.readbyqxmd.com/read/28634382/expression-of-p301l-htau-in-mouse-mec-induces-hippocampus-dependent-memory-deficit
#15
Xinghua Liu, Kuan Zeng, Mengzhu Li, Qun Wang, Rong Liu, Bin Zhang, Jian-Zhi Wang, Xiji Shu, Xiaochuan Wang
Intracellular accumulation of abnormally phosphorylated tau in different types of neurons is a pathological characteristic of Alzheimer's disease (AD). While tau modification and associated neuronal loss and hypometabolism start in the entorhinal cortex (EC) in early AD patients, the mechanism by which mutant P301L hTau leads to dementia is not fully elucidated. Here, we studied the effects of P301L hTau transduction in the medial EC (MEC) of mice on tau phosphorylation and accumulation, and cognitive deficit...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28625940/prodromal-stage-of-disease-dementia-with-lewy-bodies-how-to-diagnose-in-practice
#16
Frédéric Blanc, Marc Verny
Disease with Lewy bodies or dementia with Lewy bodies (DLB), particularly at the prodromal stage, is a complex disease to diagnose because of different clinical beginnings and variable paths in terms of clinical expression. Thus DLB can be entcountered in different input modes: mild cognitive impairment, depression, acute behavioral disorders, confusion and delirium, or sleep disorders. In the aim to better diagnose the disease, should be sought obviously to search for the key symptoms: fluctuations, hallucinations, extra-pyramidal syndrome, and REM sleep behavior disorder...
June 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28621665/neural-mechanisms-of-social-learning-in-the-female-mouse
#17
Yuan Gao, Carl Budlong, Emily Durlacher, Ian G Davison
Social interactions are often powerful drivers of learning. In female mice, mating creates a long-lasting sensory memory for the pheromones of the stud male that alters neuroendocrine responses to his chemosignals for many weeks. The cellular and synaptic correlates of pheromonal learning, however, remain unclear. We examined local circuit changes in the accessory olfactory bulb (AOB) using targeted ex vivo recordings of mating-activated neurons tagged with a fluorescent reporter. Imprinting led to striking plasticity in the intrinsic membrane excitability of projection neurons (mitral cells, MCs) that dramatically curtailed their responsiveness, suggesting a novel cellular substrate for pheromonal learning...
June 16, 2017: ELife
https://www.readbyqxmd.com/read/28598844/combustion-derived-nanoparticles-in-key-brain-target-cells-and-organelles-in-young-urbanites-culprit-hidden-in-plain-sight-in-alzheimer-s-disease-development
#18
Angélica González-Maciel, Rafael Reynoso-Robles, Ricardo Torres-Jardón, Partha S Mukherjee, Lilian Calderón-Garcidueñas
Millions of children and young adults are exposed to fine particulate matter (PM2.5) and ozone, associated with Alzheimer's disease (AD) risk. Mexico City (MC) children exhibit systemic and brain inflammation, low cerebrospinal fluid (CSF) Aβ1-42, breakdown of nasal, olfactory, alveolar-capillary, duodenal, and blood-brain barriers, volumetric and metabolic brain changes, attention and short-term memory deficits, and hallmarks of AD and Parkinson's disease. Airborne iron-rich strongly magnetic combustion-derived nanoparticles (CDNPs) are present in young urbanites' brains...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28595087/maternal-high-fat-diet-leads-to-hippocampal-and-amygdala-dendritic-remodeling-in-adult-male-offspring
#19
Yoottana Janthakhin, Marion Rincel, Anna-Maria Costa, Muriel Darnaudéry, Guillaume Ferreira
Early-life exposure to calorie-dense food, rich in fat and sugar, contributes to the increasing prevalence of obesity and its associated adverse cognitive and emotional outcomes at adulthood. It is thus critical to determine the impact of such nutritional environment on neurobehavioral development. In animals, maternal high-fat diet (HFD) consumption impairs hippocampal function in adult offspring, but its impact on hippocampal neuronal morphology is unknown. Moreover, the consequences of perinatal HFD exposure on the amygdala, another important structure for emotional and cognitive processes, remain to be established...
May 31, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28592692/genome-wide-temporal-expression-profiling-in-c-elegans-identifies-a-core-gene-set-related-to-long-term-memory
#20
Virginie Freytag, Sabine Probst, Nils Hadziselimovic, Csaba Boglari, Yannick Hauser, Fabian Peter, Bank Gabor Fenyves, Annette Milnik, Philippe Demougin, Vanja Vukojevic, Dominique J-F de Quervain, Andreas Papassotiropoulos, Attila Stetak
The identification of genes related to encoding, storage, and retrieval of memories is a major interest in neuroscience. In the current study, we analyzed the temporal gene expression changes in a neuronal mRNA pool during an olfactory long-term associative memory (LTAM) in C. elegans hermaphrodites. Here we identified a core set of 712 (538 upregulated and 174 downregulated) genes that follow three distinct temporal peaks demonstrating multiple gene regulation waves in LTAM. Comparing with the previously published positive LTAM gene sets (Lakhina et al...
June 7, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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