Igor Pomytkin, João P Costa-Nunes, Vladimir Kasatkin, Ekaterina Veniaminova, Anna Demchenko, Alexey Lyundup, Klaus-Peter Lesch, Eugene D Ponomarev, Tatyana Strekalova
While the insulin receptor (IR) was found in the CNS decades ago, the brain was long considered to be an insulin-insensitive organ. This view is currently revisited, given emerging evidence of critical roles of IR-mediated signaling in development, neuroprotection, metabolism, and plasticity in the brain. These diverse cellular and physiological IR activities are distinct from metabolic IR functions in peripheral tissues, thus highlighting region specificity of IR properties. This particularly concerns the fact that two IR isoforms, A and B, are predominantly expressed in either the brain or peripheral tissues, respectively, and neurons express exclusively IR-A...
April 24, 2018: CNS Neuroscience & Therapeutics