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César Calvo-Lobo, Francisco Unda-Solano, Daniel López-López, Irene Sanz-Corbalán, Carlos Romero-Morales, Patricia Palomo-López, Jesús Seco-Calvo, David Rodríguez-Sanz
Purpose: This study aim was to compare the effectiveness of the median nerve neural mobilization (MNNM) and cervical lateral glide (CLG) intervention versus oral ibuprofen (OI) in subjects who suffer cervicobrachial pain (CP). Methods: This investigation was a, multicenter, blinded, randomized controlled clinical trial (NCT02595294; NCT02593721). A number of 105 individuals diagnosed with CP were enrolled in the study and treated in 2 different medical facilities from July to November 2015. Participants were recruited and randomly assigned into 3 groups of 35 subjects...
2018: International Journal of Medical Sciences
Sudarshan Anandkumar, Murugavel Manivasagam
This case series describes three patients who presented with right medial elbow pain managed unsuccessfully with conservative treatment that included medication, massage, exercise therapy, ultrasound therapy, neurodynamic mobilization, and taping. Diagnosis of cubital tunnel syndrome was based on palpatory findings, a positive elbow flexion test, and a positive Tinel's sign. Conventionally, the intervention for this entrapment has been surgical decompression, with successful outcomes. This is potentially a first-time description of the successful management of cubital tunnel syndrome with dry needling (DN) using a recently published DN grading system...
March 12, 2018: Physiotherapy Theory and Practice
Antoine Bernas, Evelien M Barendse, Albert P Aldenkamp, Walter H Backes, Paul A M Hofman, Marc P H Hendriks, Roy P C Kessels, Frans M J Willems, Peter H N de With, Svitlana Zinger, Jacobus F A Jansen
Introduction: Autism spectrum disorder (ASD) is mainly characterized by functional and communication impairments as well as restrictive and repetitive behavior. The leading hypothesis for the neural basis of autism postulates globally abnormal brain connectivity, which can be assessed using functional magnetic resonance imaging (fMRI). Even in the absence of a task, the brain exhibits a high degree of functional connectivity, known as intrinsic, or resting-state, connectivity. Global default connectivity in individuals with autism versus controls is not well characterized, especially for a high-functioning young population...
February 2018: Brain and Behavior
Seval Yılmaz, Serkan Taş, Öznur Tunca Yılmaz
OBJECTIVE: The purpose of this study was to investigate the presence of median nerve mechanosensitivity by comparing median nerve neurodynamic test results of patients with nonspecific neck pain (NNP) and asymptomatic individuals. METHODS: A total of 40 patients (30 women, 10 men) with NNP between the ages of 21 and 62 years (39.53 ± 10.18 years) and 38 asymptomatic individuals (23 women, 15 men) between the ages of 18 and 60 years (37.13 ± 9.64 years) participated in the study...
February 15, 2018: Journal of Manipulative and Physiological Therapeutics
Cody A Cushing, Hee Yeon Im, Reginald B Adams, Noreen Ward, Daniel N Albohn, Troy G Steiner, Kestutis Kveraga
Fearful faces convey threat cues whose meaning is contextualized by eye gaze: While averted gaze is congruent with facial fear (both signal avoidance), direct gaze (an approach signal) is incongruent with it. We have previously shown using fMRI that the amygdala is engaged more strongly by fear with averted gaze during brief exposures. However, the amygdala also responds more to fear with direct gaze during longer exposures. Here we examined previously unexplored brain oscillatory responses to characterize the neurodynamics and connectivity during brief (~250 ms) and longer (~883 ms) exposures of fearful faces with direct or averted eye gaze...
February 9, 2018: Scientific Reports
Tiago Neto, Sandro R Freitas, Ricardo J Andrade, João Gomes, João Vaz, Bruno Mendes, Telmo Firmino, Antoine Nordez, Raúl Oliveira
Background: Neurodynamics techniques aim to assess and improve neural mechanosensitivity. However, there is no in vivo evidence regarding the mechanical effects of these techniques in the nerve stiffness. This study examined the immediate effects of a slump neurodynamics technique in the sciatic nerve shear wave velocity (SWV. i.e. an index of stiffness) using ultrasound-based elastography. Methods: Fourteen healthy participants were included in this experiment...
July 2017: Muscles, Ligaments and Tendons Journal
Fernando Marcos-Martín, Luis González-Ferrero, Noelia Martín-Alcocer, Alba Paris-Alemany, Roy La Touche
The purpose of this prospective case series was to observe and describe changes in patients with chronic cervico-craniofacial pain of muscular origin treated with multimodal physiotherapy based on a biobehavioral approach. Nine patients diagnosed with chronic myofascial temporomandibular disorder and neck pain were treated with 6 sessions over the course of 2 weeks including: (1) orthopedic manual physiotherapy (joint mobilizations, neurodynamic mobilization, and dynamic soft tissue mobilizations); (2) therapeutic exercises (motor control and muscular endurance exercises); and (3) patient education...
January 17, 2018: Physiotherapy Theory and Practice
Tomasz Wolny, Paweł Linek
OBJECTIVES: To evaluate the efficacy of neurodynamic techniques used as the sole therapeutic component compared with "sham" therapy in the treatment of mild and moderatecarpal tunnel syndromes (CTS). DESIGN: Single blinded, randomized placebo-controlled trial. SETTING: Several medical clinics in the south of Poland. PARTICIPANTS: Volunteer sample of 150 patients diagnosed with CTS. MAIN OUTCOME MEASURES: Symptom severity (SSS) and Functional status (FSS) of Boston Carpal Tunnel Questionnaire (BCTQ)...
January 4, 2018: Archives of Physical Medicine and Rehabilitation
Antoine Bernas, Albert P Aldenkamp, Svitlana Zinger
BACKGROUND AND OBJECTIVE: The autism spectrum disorder (ASD) diagnosis requires a long and elaborate procedure. Due to the lack of a biomarker, the procedure is subjective and is restricted to evaluating behavior. Several attempts to use functional MRI as an assisting tool (as classifier) have been reported, but they barely reach an accuracy of 80%, and have not usually been replicated or validated with independent datasets. Those attempts have used functional connectivity and structural measurements...
February 2018: Computer Methods and Programs in Biomedicine
Carlo Cottone, Andrea Cancelli, Patrizio Pasqualetti, Camillo Porcaro, Carlo Salustri, Franca Tecchio
In this paper, we pose the following working hypothesis: in humans, transcranial electric stimulation (tES) with a time course that mimics the endogenous activity of its target is capable of altering the target's excitability. In our case, the target was the primary motor cortex (M1). We identified the endogenous neurodynamics of hand M1's subgroups of pyramidal neuronal pools in each of our subjects by applying Functional Source Separation (FSS) to their EEG recordings. We then tested whether the corticospinal excitability of the hand representation under the above described stimulation, which we named transcranial individual neurodynamics stimulation (tIDS), was higher than in the absence of stimulation (baseline)...
January 17, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Emmi Mikanmaa, Tineke Grent-'t-Jong, Lingling Hua, Marc Recasens, Hanna Thune, Peter J Uhlhaas
The identification of biomarkers for the early diagnosis of schizophrenia that could inform novel treatment developments is an important objective of current research. This paper will summarize recent work that has investigated changes in oscillatory activity and event-related potentials with Electro/Magnetoencephalography (EEG/MEG) in participants at high-risk for the development of schizophrenia, highlighting disruptions in sensory and cognitive operations prior to the onset of the syndrome. Changes in EEG/MEG-data are consistent with evidence for alterations in Glutamatergic and GABAergic neurotransmission as disclosed by Magnetic Resonance Spectroscopy and brain stimulation, indicating changes in Excitation/Inhibition balance parameters prior to the onset of psychosis...
November 22, 2017: NeuroImage
Brandon Keehn, Marissa Westerfield, Ralph-Axel Müller, Jeanne Townsend
Background: Autism spectrum disorder (ASD) is associated with deficits in adaptively orienting attention to behaviorally-relevant information. Neural oscillatory activity plays a key role in brain function and provides a high-resolution temporal marker of attention dynamics. Alpha band (8-12 Hz) activity is associated with both selecting task-relevant stimuli and filtering task-irrelevant information. Methods: The present study used electroencephalography (EEG) to examine alpha-band oscillatory activity associated with attentional capture in nineteen children with ASD and twenty-one age- and IQ-matched typically developing (TD) children...
September 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Tomasz Wolny
BACKGROUND: Carpal tunnel syndrome (CTS) is the most common peripheral neuropathy, characterized by the presence of many sensory and motor abnormalities. In the physiotherapy of patients with CTS, neurodynamic tech-niques are very common, while the scientific literature does not show clear evidence of beneficial effects obtained by using these techniques. Therefore, the aim of this work was to critically evaluate the use of neurodynamic techniques in the conservative treatment of CTS...
October 31, 2017: Ortopedia, Traumatologia, Rehabilitacja
Min-Hee Ahn, Sung Kwang Hong, Byoung-Kyong Min
Tinnitus is a psychoacoustic phantom perception of currently unknown neuropathology. Despite a growing number of post-stimulus tinnitus studies, uncertainty still exists regarding the neural signature of tinnitus in the resting-state brain. In the present study, we used high-gamma cross-frequency coupling and a Granger causality analysis to evaluate resting-state electroencephalographic (EEG) data in healthy participants and patients with tinnitus. Patients with tinnitus lacked robust frontal delta-phase/central high-gamma-amplitude coupling that was otherwise clearly observed in healthy participants...
December 2017: Hearing Research
Martina Knežević, Ksenija Marinković
Response inhibition, a key executive function, continues to develop in early adulthood in parallel with maturational processes of the underlying prefrontal regions known to support it. The current study examined behavioral and neurophysiological correlates of response inhibition during a visual Go/No-Go task in a large sample (N = 120) comprised of participants in their Early 20s (ages 19-21), Mid 20s (ages 23-27), and Early 30s (ages 28-42). The two younger groups had lower accuracy, shorter reaction times, and made more premature responses compared to Early 30s...
July 2017: Cognitive Development
Xinyi Le, Sijie Chen, Zheng Yan, Juntong Xi
In this paper, a distributed neurodynamic approach is proposed for constrained convex optimization. The objective function is a sum of local convex subproblems, whereas the constraints of these subproblems are coupled. Each local objective function is minimized individually with the proposed neurodynamic optimization approach. Through information exchange between connected neighbors only, all nodes can reach consensus on the Lagrange multipliers of all global equality and inequality constraints, and the decision variables converge to the global optimum in a distributed manner...
October 18, 2017: IEEE Transactions on Cybernetics
Blanca Romero-Moraleda, Roy La Touche, Sergio Lerma-Lara, Raúl Ferrer-Peña, Víctor Paredes, Ana Belén Peinado, Daniel Muñoz-García
OBJECTIVES: Compare the immediate effects of a Neurodynamic Mobilization (NM) treatment or foam roller (FR) treatment after DOMS. DESIGN: Double blind randomised clinical trial. SETTING: The participants performed 100 drop jumps (5 sets of 20 repetitions, separated by 2 min rests) from a 0.5-m high box in a University biomechanics laboratory to induce muscle soreness. The participants were randomly assigned in a counter-balanced fashion to either a FR or NM treatment group...
2017: PeerJ
Calvin K Young, Ming Ruan, Neil McNaughton
Algorithms for estimating directed connectivity have become indispensable to further understand the neurodynamics between functionally coupled brain areas. The evaluation of directed connectivity on the propagation of brain activity has largely been based on simulated data or toy models, where various hidden properties of neurophysiological data may not be fully recapitulated. In this study, directionality was unequivocally manipulated in the freely moving rat in a unique dataset, where normal oscillatory interactions between the supramammillary nucleus (SuM) and hippocampus (HPC) were attenuated by temporary medial septal (MS) inactivation, and replaced by electrical stimulation of the fornix to evaluate the performance of several directed connectivity assessment methods...
2017: Frontiers in Systems Neuroscience
Pedro Fuentes-Márquez, Marie Carmen Valenza, Irene Cabrera-Martos, Ana Ríos-Sánchez, Olga Ocón-Hernández
Objectives: This study aims to evaluate the presence of myofascial trigger points (TrPs), widespread pressure pain sensitivity, and mechanosensitivity of neural tissue in women with chronic pelvic pain. Design: Case-control study. Setting: Faculty of Health Sciences. Subjects: Forty women with chronic pelvic pain between age 18 and 60 years and 40 matched healthy controls were included in the study. Methods: TrPs were bilaterally explored in gluteus maximus, gluteus medius, gluteus minimus, quadratus lumborum, and adductor magnus muscles...
August 25, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Michael J Tobia, Koby Hayashi, Grey Ballard, Ian H Gotlib, Christian E Waugh
Exposure to acute stress induces multiple emotional responses, each with their own unique temporal dynamics. Dynamic functional connectivity (dFC) measures the temporal variability of network synchrony and captures individual differences in network neurodynamics. This study investigated the relationship between dFC and individual differences in emotions induced by an acute psychosocial stressor. Sixteen healthy adult women underwent fMRI scanning during a social evaluative threat (SET) task, and retrospectively completed questionnaires that assessed individual differences in subjectively experienced positive and negative emotions about stress and stress relief during the task...
September 20, 2017: Human Brain Mapping
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