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https://www.readbyqxmd.com/read/29775695/pulsatilla-decoction-inhibits-candida-albicans-proliferation-and-adhesion-in-a-mouse-model-of-vulvovaginal-candidiasis-via-the-dectin-1-signaling-pathway
#1
Lilin Yang, Haiwang Wu, Weiyu Qiu, Longyi Guo, Xin Du, Qingying Yu, Jie Gao, Songping Luo
ETHNOPHARMACOLOGICAL RELEVANCE: Pulsatilla decoction (PD) is a classical prescription in Traditional Chinese Medicine (TCM) and has been reported to have inhibitory effects on Candida albicans proliferation. STUDY AIM: To investigate the therapeutic effects of PD in the treatment of Vulvovaginal candidiasis (VVC) and elucidate the potential mechanism. MATERIALS AND METHODS: Female BALB/c mice (N=90) were randomized to six treatment groups, including the Control group, Model group, three PD groups and Fluconazole group which served as a positive control (20mg/kg weekly)...
May 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29772866/-candidiasis-of-the-esophagus-caused-by-anterior-cervical-surgery-a-case-report
#2
Hua-Yan Chen, Wei Li, Yi Zhang
No abstract text is available yet for this article.
April 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29771293/breakthrough-fungal-infections-in-leukemia-patients-receiving-isavuconazole
#3
Caitlin R Rausch, Adam J DiPippo, Prithviraj Bose, Dimitrios P Kontoyiannis
Isavuconazole (ISA) is increasingly used in leukemia patients. We retrospectively assessed breakthrough invasive fungal infections (b-IFIs) in 100 consecutive leukemia patients receiving ISA as single agent; 13 developed documented b-IFIs. (6 candidiasis, 6 mold infections, 4 mucormycosis). All b-IFIs were observed in patients with prolonged neutropenia and active leukemia.
May 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29767615/relevance-of-antifungal-penetration-in-biofilm-associated-resistance-of-candida-albicans-and-non-albicans-candida-species
#4
Rachna Singh, Anjna Kumari, Karminder Kaur, Parul Sethi, Arunaloke Chakrabarti
The role of penetration limitation in Candida biofilm-associated antifungal resistance remains unclear. Most of the previous work has been done on Candida albicans, although non-albicans (NAC) species are also implicated in invasive candidiasis and the biofilm matrix has been shown to vary amongst different species. Only a few studies have evaluated clinical isolates. This study aimed to determine the relevance of penetration limitation in the antifungal resistance of biofilms formed by C. albicans and NAC clinical isolates, using an agar disk diffusion assay...
May 16, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29766800/antifungal-activity-gas-chromatographic-mass-spectrometric-analysis-and-in-silico-study-of-punica-granatum-peel-extracts-against-fluconazole-resistant-strains-of-candida-species
#5
Sony Paul, M Kalyani, I Kannan
AIMS: Candida species is the common cause of opportunistic fungal infections all over the world with increased mortality and morbidity especially in immunosuppressed patients. Fluconazole is the first line therapy for candidiasis. The antifungal resistance pattern in high-risk patients is a major concern. The present study was aimed to assess the anticandidal activity of Punica granatum peel against fluconazole resistant Candida species isolated from HIV patients. MATERIALS & METHODS: Ethanol, chloroform, petroleum ether and aqueous extracts of the peel of P...
May 14, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29766516/radiographic-bone-loss-in-a-scottish-non-smoking-type-1-diabetes-mellitus-population-a-bitewing-radiographic-study
#6
Anastasios Plessas, Douglas P Robertson, Penny J Hodge
BACKGROUND: The dental complications of uncontrolled diabetes include reduced salivary flow rate, candidiasis and periodontal manifestations. A recent meta-analysis concluded that diabetes patients have a significantly higher severity, but not extent, of destructive periodontal disease than non-diabetes people. The authors reported that most type-1 diabetes studies using dental radiographic data have not controlled for confounding factors such as smoking. The aim of this cross-sectional study was to compare radiographic alveolar bone loss between type 1 diabetes (T1DM) and non-diabetes (NDM) participants in a Scottish non-smoking population...
May 15, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29763829/silver-loaded-graphene-as-an-effective-sers-substrate-for-clotrimazole-detection-dft-and-spectroscopic-studies
#7
Abdulmujeeb T Onawole, Saheed A Popoola, Tawfik A Saleh, Abdulaziz A Al-Saadi
Vibrational infrared, Raman and surface-enhanced Raman scattering (SERS) spectra of clotrimazole (CTZ) were documented and evaluated. Density-functional theory, B3LYP/6-311++G(d,p), approach was implemented to identify the possible conformations, develop the electrostatic potential map, evaluate frontier molecular orbitals and calculate the vibrational spectra of the target compound. The silver-loaded graphene was shown to be an effective SERS substrate for CTZ trace detection. The SERS spectrum showed two enhanced bands at 670 cm-1 and 700 cm-1 which confirmed the absorption of the silver substrate through chlorine and nitrogen atoms...
May 7, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29762386/exposure-response-analysis-of-micafungin-in-neonatal-candidiasis-pooled-analysis-of-two-clinical-trials
#8
Laura L Kovanda, Thomas J Walsh, Daniel K Benjamin, Antonio Arrieta, David A Kaufman, P Brian Smith, Paolo Manzoni, Amit V Desai, Atsunori Kaibara, Peter L Bonate, William W Hope
BACKGROUND: Neonatal candidiasis causes significant morbidity and mortality in high risk infants. The micafungin dosage regimen of 10 mg/kg established for the treatment of neonatal candidiasis is based on a laboratory animal model of neonatal hematogenous Candida meningoencephalitis and pharmacokinetic (PK)-pharmacodynamic (PD) bridging studies. However, little is known about the how these PK-PD data translate clinically. METHODS: Micafungin plasma concentrations from infants were used to construct a population PK model using Pmetrics software...
June 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29762142/cytology-preparations-of-formalin-fixative-aid-detection-of-giardia-in-duodenal-biopsy-samples-a-helpful-tool-for-diagnosing-esophageal-candidiasis-as-well
#9
Sören Schröder, Thomas Günther
No abstract text is available yet for this article.
May 14, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29760552/patients-receiving-chiropractic-care-in-a-neurorehabilitation-hospital-a-descriptive-study
#10
Robert D Vining, Stacie A Salsbury, W Carl Cooley, Donna Gosselin, Lance Corber, Christine M Goertz
Objectives: Individuals rehabilitating from complex neurological injury require a multidisciplinary approach, which typically does not include chiropractic care. This study describes inpatients receiving multidisciplinary rehabilitation including chiropractic care for brain injury, spinal cord injury (SCI), stroke, and other complex neurological conditions. Design: Chiropractic services were integrated into Crotched Mountain Specialty Hospital (CMSH) through this project...
2018: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/29760550/synergistic-antifungal-effect-of-chitosan-stabilized-selenium-nanoparticles-synthesized-by-pulsed-laser-ablation-in-liquids-against-candida-albicans-biofilms
#11
Humberto H Lara, Gregory Guisbiers, Jonathan Mendoza, Lawrence C Mimun, Brandy A Vincent, Jose L Lopez-Ribot, Kelly L Nash
Background: Candida albicans is a major opportunistic fungal pathogen. One of the most important virulence factors that contribute to the pathogenesis of candidiasis is its ability to form biofilms. A key characteristic of Candida biofilms is their resistance to antifungal agents. Due to significant morbidity and mortality rates related to biofilm-associated drug resistance, there is an urgency to develop novel nanotechnology-based approaches preventing biofilm-related infections. Methods: In this study, we report, for the first time, the synthesis of selenium nanoparticles by irradiating selenium pellets by nanosecond pulsed laser ablation in liquid chitosan as a capping agent...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29755472/the-elusive-anti-candida-vaccine-lessons-from-the-past-and-opportunities-for-the-future
#12
REVIEW
Gloria Hoi Wan Tso, Jose Antonio Reales-Calderon, Norman Pavelka
Candidemia is a bloodstream fungal infection caused by Candida species and is most commonly observed in hospitalized patients. Even with proper antifungal drug treatment, mortality rates remain high at 40-50%. Therefore, prophylactic or preemptive antifungal medications are currently recommended in order to prevent infections in high-risk patients. Moreover, the majority of women experience at least one episode of vulvovaginal candidiasis (VVC) throughout their lifetime and many of them suffer from recurrent VVC (RVVC) with frequent relapses for the rest of their lives...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29753928/dynamic-changes-of-th1-th2-th17-cytokines-and-human-beta-defensin-2-in-hiv-infected-patients-with-oral-candidiasis-during-the-first-year-of-highly-active-anti-retroviral-therapy
#13
Xiangzhi Yong, Zhenmin Liu, Lanlan Jiang, Renchuan Tao, Wei Liu, Linlin Zhang, Yuanyuan Peng, Xuefang Lin, Yuxiao Huang
OBJECTIVE: To investigate the change of Th1/Th2/Th17 cytokines and human beta defensin 2 (HBD-2) in HIV-infected patients with oral candidiasis (OC) and gather information about OC-specific immunity. DESIGN: During the 1st year of highly active anti-retroviral therapy (HAART), 25 HIV-infected patients were followed up at the baseline, 3rd, 6th, 12th month. At each visit, oral manifestations were examined; oral rinses were collected and cultured for Candida; peripheral venous blood was taken to determine CD4 + T cell counts and HIV RNA viral load (VL); both unstimulated whole saliva and peripheral venous blood were taken to determine cytokine (IL-4, IL-17(A/F), IFN-γ) and HBD-2 levels...
May 3, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29749387/invasive-candidiasis
#14
REVIEW
Peter G Pappas, Michail S Lionakis, Maiken Cavling Arendrup, Luis Ostrosky-Zeichner, Bart Jan Kullberg
Invasive candidiasis is an important health-care-associated fungal infection that can be caused by several Candida spp.; the most common species is Candida albicans, but the prevalence of these organisms varies considerably depending on geographical location. The spectrum of disease of invasive candidiasis ranges from minimally symptomatic candidaemia to fulminant sepsis with an associated mortality exceeding 70%. Candida spp. are common commensal organisms in the skin and gut microbiota, and disruptions in the cutaneous and gastrointestinal barriers (for example, owing to gastrointestinal perforation) promote invasive disease...
May 11, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29749385/invasive-candidiasis
#15
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
May 11, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29747232/efficacy-and-safety-of-ixekizumab-in-a-randomized-double-blinded-placebo-controlled-phase-3b-study-of-patients-with-moderate-to-severe-genital-psoriasis
#16
C Ryan, A Menter, L Guenther, A Blauvelt, R Bissonnette, K Meeuwis, J Sullivan, J C Cather, G Yosipovitch, A B Gottlieb, J F Merola, K Callis Duffin, S Fretzin, O O Osuntokun, R Burge, A N Naegeli, F E Yang, C-Y Lin, K Todd, A Potts Bleakman
BACKGROUND: Genital psoriasis (GenPs) is a common, debilitating, and difficult to treat manifestation of plaque psoriasis. However, few controlled, interventional studies of GenPs exist. OBJECTIVE: To determine the efficacy of ixekizumab versus placebo in patients with moderate-to-severe GenPs with BSA≥1%. METHODS: Subjects with moderate-to-severe GenPs (defined as a baseline static Physician's Global Assessment of Genitalia [sPGA-G] score of ≥3) with BSA≥1% were randomized 1:1 to receive placebo (N=74) or the recommended dosing of ixekizumab (N=75)...
May 10, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29746162/antifungal-activity-of-essential-oils-against-azole-resistant-and-azole-susceptible-i-i-candida-glabrata-i-i-strains-vaginal-isolates
#17
Nadia Massa, Simone Cantamessa, Giorgia Novello, Elia Ranzato, Simona Martinotti, Matteo Pavan, Andrea Rocchetti, Graziella Berta, Elisa Gamalero, Elisa Bona
<i></i>Candida glabrata<i></i> is an opportunistic pathogen, associated with endocarditis, meningitis and disseminated disease and also with complicated vaginitis. Essential oils derived from aromatic plants are known in traditional medicine as antimicrobial agents and have antifungal properties. The aim of this work was to evaluate whether the twelve tested essential oils (tea tree, laurel, anise, basil, bergamot, lavender, mint, oregano, grapefruit, rosemary, winter savory and ginger) could have a transverse effect on <i></i>C...
May 10, 2018: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/29744900/pharmacokinetics-and-safety-of-fluconazole-and-micafungin-in-neonates-with-systemic-candidiasis-a-randomized-open-label-clinical-trial
#18
S Leroux, E Jacqz Aigrain, V Elie, F Legrand, C Barin-Le Guellec, B Aurich, V Biran, B Dusang, S Goudjil, S Coopman, R Garcia Sanchez, W Zhao, P Manzoni
AIMS: Pharmacokinetics (PK) of fluconazole and micafungin differ in neonates compared with children and adults. Dosing instructions in product labels appear inconsistent with the emerging scientific evidence. Limited information is available on their safety profile in neonates. Our objective was to study population PK and safety of both drugs, randomly administered in neonates with suspected or confirmed systemic candidiasis. METHODS: Neonates were randomized 1:1 to fluconazole (loading dose 25mg/kg; maintenance dose 12 or 20mg/kg/day for infants <30 or ≥ 30 weeks corrected gestational age) or micafungin (loading dose 15mg/kg/day; maintenance dose 10mg/kg/day)...
May 10, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29743305/five-year-national-surveillance-of-invasive-candidiasis-species-distribution-and-azole-susceptibility-from-the-china-hospital-invasive-fungal-surveillance-net-chif-net-study
#19
Meng Xiao, Zi-Yong Sun, Mei Kang, Da-Wen Guo, Kang Liao, Sharon C-A Chen, Fanrong Kong, Xin Fan, Jing-Wei Cheng, Xin Hou, Meng-Lan Zhou, Ying Li, Shu-Ying Yu, Jing-Jing Huang, He Wang, Ying-Chun Xu
Data on the epidemiology of invasive candidiasis (IC) and antifungal susceptibility of Candida isolates in China are still limited. Here we report surveillance for IC from the China Hospital Invasive Fungal Surveillance Net (CHIF-NET) Study. Sixty-five tertiary hospitals collected 8,829 Candida isolates from August 1, 2009 to July 31, 2014. Matrix-assisted laser desorption/ionization -time of flight mass spectrometry supplemented by rDNA sequencing was used to define species, and fluconazole and voriconazole susceptibilities determined by the Clinical and Laboratory Standards Institute disk diffusion method...
May 9, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29742781/-enhanced-microscopic-diagnosis-of-oesophageal-candidiasis-through-additional-cytospin-analysis-of-the-fixative-of-oesophageal-biopsies
#20
Sören Schröder, Thomas Günther
To confirm or to refute the diagnosis of candida oesophagitis as the most common infectious disease of the oesophagus is a standard diagnostic procedure in histopathology. The fungal hyphae colonise mainly the superficial layers of the oesophageal squamous mucosa. Tangentially cut sections of oesophageal biopsies in the paraffin block might lead to a false negative result concerning mycotic infection. The aim of this study was to investigate whether cytospin analysis of the formalin fixative in which the biopsies were stored and transported would be a tool to close the diagnostic gap...
May 9, 2018: Zeitschrift Für Gastroenterologie
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