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https://www.readbyqxmd.com/read/29154465/the-role-of-immunological-testing-and-intervention-in-reproductive-medicine-a-fertile-collaboration
#1
REVIEW
Syed B Ali, Yogesh Jeelall, Craig E Pennell, Roger Hart, Andrew McLean-Tooke, Michaela Lucas
Advances in reproductive medicine have significantly increased the success of fertility treatments. Nevertheless, some women experience recurrent implantation failure (RIF) after in-vitro fertilization (IVF) or recurrent pregnancy loss (RPL). Imbalances in the immune system and failure to achieve immune tolerance to the foetus have been implicated as potentially modifiable causes of idiopathic RIF and RPL. As such, women are increasingly being treated with immunomodulatory agents in an attempt to achieve a successful pregnancy...
November 20, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29154201/neuroendocrine-disorder-in-chronic-fatigue-syndrome
#2
Slavica Tomic, Snezana Brkic, Dajana Lendak, Daniela Maric, Milica Medic Stojanoska, Aleksandra Novakov Mikic
Background/aim: Neuroendocrine disorders are considered a possible pathogenetic mechanism in chronic fatigue syndrome (CFS). The aim of our study was to determine the function of the hypothalamic-pituitary-adrenal axis (HPA) and thyroid function in women of reproductive age suffering from CFS. Materials and methods: The study included 40 women suffering from CFS and 40 healthy women (15-45 years old). Serum levels of cortisol (0800 and 1800 hours), ACTH, total T4, total T3, and TSH were measured in all subjects...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29151191/silica-nanoparticle-exposure-inducing-granulosa-cell-apoptosis-and-follicular-atresia-in-female-balb-c-mice
#3
Jianhui Liu, Man Yang, Li Jing, Lihua Ren, Jialiu Wei, Jin Zhang, Feng Zhang, Junchao Duan, Xianqing Zhou, Zhiwei Sun
Given that the effects of ultrafine fractions (< 0.1 μm) on reproductive diseases are gaining attention, this study aimed to explore the influence of silica nanoparticle (SiNP)-induced female reproductive dysfunction. In this study, 80 female mice were randomly divided into four groups including a control group and three concentrations of SiNP groups (7, 21, 35 mg/kg). Mice were exposed to the vehicle control and silica nanoparticles by tracheal perfusion every 3 days a total of five times in 15 days...
November 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29151001/intravenous-fluid-therapy-for-hospitalized-and-critically-ill-children-rationale-available-drugs-and-possible-side-effects
#4
Thomas Langer, Rosamaria Limuti, Concezione Tommasino, Niels van Regenmortel, Els L I M Duval, Pietro Caironi, Manu L N G Malbrain, Antonio Pesenti
Human beings are constituted mainly of water. In particular, children's total body water might reach 75-80% of their body weight, compared to 60-70% in adults. It is therefore not surprising, that children, especially hospitalized newborns and infants, are markedly prone to water and electrolyte imbalances. Parenteral fluid therapy is a cornerstone of medical treatment and is thus of exceptional relevance in this patient population. It is crucial to appreciate the fact that intravenous fluids are drugs with very different characteristics, different indications, contraindications and relevant side effects...
November 18, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/29147785/qt-interval-and-dispersion-in-drug-free-anorexia-nervosa-adolescents-a-case-control-study
#5
Monica Bomba, Lucio Tremolizzo, Fabiola Corbetta, Franco Nicosia, Francesca Lanfranconi, Gianni Poggioli, Karine Goulene, Marco Stramba-Badiale, Elisa Conti, Francesca Neri, Renata Nacinovich
Long QT values have been reported in patients with anorexia nervosa of the restricting type (ANr) potentially increasing the risk of fatal arrhythmia, especially if psychotropic drug treatment is required. Nevertheless, the previous studies on this topic are biased by drug exposure, long disease durations, and small sample sizes. This study is aimed at assessing QTc and QTcd values in ANr adolescents with recent onset and drug free, as compared to subjects affected by psychiatric disorders other than ANr. We evaluated QTc and its dispersion (QTcd) in a population of 77 drug-free ANr female adolescents and compared to an equal number of healthy controls (H-CTRL) and pathological controls (P-CTRL, mixed psychiatric disorders)...
November 16, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29142409/reversible-testicular-toxicity-of-piperine-on-male-albino-rats
#6
Gopichand Chinta, Mohane Selvaraj Coumar, Latha Periyasamy
Background: Piperine was widely used in traditional medicine for inducing sterility and abortion. Objective: To evaluate the effect of the piperine on testis of male albino rats. Materials and Methods: Adult male rats were divided into four groups (n = 12). Group I (control): Rats were given vehicle p.o. i.e. 0.5% carboxymethyl cellulose in normal saline daily for 60 days, Group II (ED): Rats received piperine at a dose of 10 mg/kg body weight (b...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29141973/energy-metabolism-profile-in-individuals-with-prader-willi-syndrome-and-implications-for-clinical-management-a-systematic-review
#7
REVIEW
Maha Alsaif, Sarah A Elliot, Michelle L MacKenzie, Carla M Prado, Catherine J Field, Andrea M Haqq
Prader-Willi syndrome (PWS) is a rare genetic disorder associated with excessive weight gain. Hyperphagia associated with PWS may result in higher energy intake, but alterations in energy expenditure may also contribute to energy imbalance. The purpose of this critical literature review is to determine the presence of alterations in energy expenditure in individuals with PWS. Ten studies that measured total energy expenditure (TEE), resting energy expenditure (REE), sleep energy expenditure (SEE), activity energy expenditure (AEE), and diet induced thermogenesis (DIT) were included in this review...
November 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/29134689/effectiveness-of-controlled-internal-drug-release-device-treatment-to-alleviate-reproductive-seasonality-in-anestrus-lactating-or-dry-barki-and-rahmani-ewes-during-non-breeding-season
#8
M Y El-Mokadem, Anm Nour El-Din, T A Ramadan, A M Rashad, T A Taha, M A Samak, M H Salem
This study aimed to evaluate the effectiveness of hormonal treatments on ovarian activity and reproductive performance in Barki and Rahmani ewes during non-breeding season. Forty-eight multiparous ewes, 24 Barki and 24 Rahmani ewes were divided into two groups, 12 lactating and 12 dry ewes for each breed. Controlled internal drug release (CIDR) device was inserted in all ewes for 14 days in conjunction with intramuscular 500 IU equine chronic gonadotrophin (eCG) at day of CIDR removal. Data were analysed using PROC MIXED of SAS for repeated measures...
November 14, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29124437/optimal-vitamin-d-intake-for-preventing-serum-25-hydroxyvitamin-d-insufficiency-in-young-japanese-women
#9
Hiroaki Ohta, Tatsuhiko Kuroda, Naoko Tsugawa, Yoshiko Onoe, Toshio Okano, Masataka Shiraki
Populations of East Asian countries have been known to have low calcium intakes and low serum 25(OH)D concentrations, suggesting that Ca and vitamin D (VitD)-deficiencies are commonly observed. These nutritional imbalances may lead to low peak bone mass (PBM). The low PBM seen in Ca/VitD-deficient individuals may lead to osteoporosis, as well as an increased risk of fracture. A survey was conducted in young Japanese women (n = 296, 21.2 ± 2.3 years old) on their Ca/VitD intakes and serum 25(OH)D levels, which demonstrated a significant positive correlation between VitD intake and serum 25(OH)D levels (R (2) = 0...
November 9, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29121700/difference-in-the-gut-microbiome-between-ovariectomy-induced-obesity-and-diet-induced-obesity
#10
Sungmi Choi, Yu-Jin Hwang, Min-Jeong Shin, Hana Yi
During menopausal transition, the imbalance of estrogen causes body weight gain. Although gut microbiome dysbiosis has been reported in postmenopausal obesity, it is not clear whether there is any difference in the microbiome profile between dietary-induced obesity and postmenopausal obesity. Therefore, in this study, we analyzed intestinal samples from ovariectomized mice and compared them to those of mice with high fat diet-induced obesity. To further evaluate the presence of menopause-specific bacteria-gene interactions, we also analyzed the liver transcriptome...
November 9, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29121167/basal-cells-show-increased-expression-of-aromatase-and-estrogen-receptor-%C3%AE-in-prostate-epithelial-lesions-of-male-aging-rats
#11
Monica Morais-Santos, Hipácia Werneck-Gomes, Gabriel H Campolina-Silva, Leticia C Santos, Germán A B Mahecha, Rex A Hess, Cleida A Oliveira
Besides androgens, estrogen signaling plays key role in normal development and pathologies of the prostate. Irreversible synthesis of estrogens from androgens is catalyzed by aromatase. Interestingly, animals lacking aromatase do not develop cancer or prostatitis, whereas those with overexpression of aromatase and consequently high estrogen levels, develop prostatitis and squamous metaplasia via estrogen receptor 1 (ERα). Even with this evidence, the aromatase expression in the prostate is controversial. Moreover, little is known about the occurrence of age-dependent variation of aromatase and its association with histopathological changes commonly found in advanced age, a knowledge gap that is addressed herein...
November 7, 2017: Endocrinology
https://www.readbyqxmd.com/read/29113826/ghrelin-suppresses-cardiac-fibrosis-of-post-myocardial-infarction-heart-failure-rats-by-adjusting-the-activin-a-follistatin-imbalance
#12
Chunyan Yang, Jinsha Liu, Kai Liu, Beibei Du, Kaiyao Shi, Mei Ding, Bing Li, Ping Yang
Ghrelin, a growth hormone-releasing peptide, potentially improves cardiac function, but the mechanisms remain unclear. In the study, the rat heart failure (HF) model was established by ligating the left anterior descending coronary artery (LAD) and treated with ghrelin (100μg/kg, subcutaneous injection, bid); neonatal rat cardiomyocytes were cultured and stimulated with Ang II (0.1μM) and ghrelin(0.1μM) to explore the underlying mechanism of ghrelin in myocardial remodeling. Hemodynamic changes and serum brain natriuretic peptide (BNP) concentrations were measured to assess cardiac function...
November 4, 2017: Peptides
https://www.readbyqxmd.com/read/29103113/testicular-toxicity-and-sperm-quality-following-copper-exposure-in-wistar-albino-rats-ameliorative-potentials-of-l-carnitine
#13
Maurya Khushboo, Meesala Krishna Murthy, Maibam Sunita Devi, Sanasam Sanjeev, Kalibulla Syed Ibrahim, Nachimuthu Senthil Kumar, Vikas Kumar Roy, Guruswami Gurusubramanian
Copper is a persistent toxic and bio-accumulative heavy metal of global concern. Continuous exposure of copper compounds of different origin is the most common form of copper poisoning and in turn adversely altering testis morphology and function and affecting sperm quality. L-carnitine has a vital role in the spermatogenesis, physiology of sperm, sperm production and quality. This study was designed to examine whether the detrimental effects of long-term copper consumption on sperm quality and testis function of Wistar albino rat could be prevented by L-carnitine therapy...
November 4, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29101650/regulation-of-bone-metabolism-by-serotonin
#14
Brigitte Lavoie, Jane B Lian, Gary M Mawe
The processes of bone growth and turnover are tightly regulated by the actions of various signaling molecules, including hormones, growth factors, and cytokines. Imbalances in these processes can lead to skeletal disorders such as osteoporosis or high bone mass disease. It is becoming increasingly clear that serotonin can act through a number of mechanisms, and at different locations in the body, to influence the balance between bone formation and resorption. Its actions on bone metabolism can vary, based on its site of synthesis (central or peripheral) as well as the cells and subtypes of receptors that are activated...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29100054/systems-phytohormone-responses-to-mitochondrial-proteotoxic-stress
#15
Xu Wang, Johan Auwerx
Mitochondrial function is controlled by two separate genomes. This feature makes mitochondria prone to proteotoxic stress when a stoichiometric imbalance occurs in the protein complexes that perform oxidative phosphorylation, which consist of both nuclear- and mitochondrial-encoded proteins. Such a proteotoxic stress is known to induce the mitochondrial unfolded protein response (UPR(mt)) in animals. It is unknown whether UPR(mt) occurs in plants. Here, we induced a mitonuclear protein imbalance in Arabidopsis through chemical or genetic interference...
November 2, 2017: Molecular Cell
https://www.readbyqxmd.com/read/29095507/social-hair-pulling-in-captive-rhesus-macaques-macaca-mulatta
#16
Allison Heagerty, Rebecca A Wales, Kamm Prongay, Daniel H Gottlieb, Kristine Coleman
Alopecia is common among captive populations of nonhuman primates. There are many potential causes of alopecia, including physiological conditions such as hormonal imbalance and infection, features of the captive environment such as housing type, ground substrate, and group density, as well as behavioral abnormalities such as self-plucking. A potential behavioral cause of alopecia in group-housed primates is social hair pulling, where one animal pulls hair from a conspecific. While social hair pulling has been conflated with overgrooming in some of the alopecia literature, other authors have categorized it as a form of aggression rather than a form of excessive grooming...
November 2, 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/29092905/estrogen-induces-egr1-to-fine-tune-its-actions-on-uterine-epithelium-by-controlling-pr-signaling-for-successful-embryo-implantation
#17
Hye-Ryun Kim, Yeon Sun Kim, Jung Ah Yoon, Seung Chel Yang, Mira Park, Dong-Won Seol, Sang Woo Lyu, Jin Hyun Jun, Hyunjung Jade Lim, Dong Ryul Lee, Haengseok Song
The harmonized actions of ovarian E2 and progesterone (P4) regulate the proliferation and differentiation of uterine cells in a spatiotemporal manner. Imbalances between these hormones often lead to infertility and gynecologic diseases. Whereas numerous factors that are involved in P4 signaling have been identified, few local factors that mediate E2 actions in the uterus have been revealed. Here, we demonstrate that estrogen induces the transcription factor, early growth response 1 (Egr1), to fine-tune its actions in uterine epithelial cells (ECs) that are responsible for uterine receptivity for embryo implantation...
November 1, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29089199/microrna-27a-3p-affects-estradiol-and-androgen-imbalance-by-targeting-creb1-in-the-granulosa-cells-in-mouse-polycytic-ovary-syndrome-model
#18
Mingming Wang, Mei Liu, Jing Sun, Lina Jia, Shuoqian Ma, Jun Gao, Yunyun Xu, Hongwen Zhang, Suk Ying Tsang, Xiangdong Li
Polycystic ovary syndrome (PCOS) is a common endocrine abnormality in women characterized by a menstrual disturbance with chronic anovulation and hyperandrogenism, polycystic ovaries, and insulin resistance. MicroRNAs (miRNAs) are important fine-tune regulators involved in various physiological and pathological processes, but their actions are not fully understood. In this study, we observed the increased expression of miR-27a-3p in the ovaries of mice with PCOS and explored its functions in primary mouse granulosa cells (mGCs) and the mouse granulosa-like tumor cell line, KK-1, using several approaches...
October 28, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/29080701/g-protein-coupled-receptors-as-anabolic-drug-targets-in-osteoporosis
#19
REVIEW
Natalie Diepenhorst, Patricia Rueda, Anna E Cook, Philippe Pastoureau, Massimo Sabatini, Christopher J Langmead
Osteoporosis is a progressive bone disorder characterised by imbalance between bone building (anabolism) and resorption (catabolism). Most therapeutics target inhibition of osteoclast-mediated bone resorption, but more recent attention in early drug discovery has focussed on anabolic targets in osteoblasts or their precursors. Two marketed agents that display anabolic properties, strontium ranelate and teriparatide, mediate their actions via the G protein-coupled calcium-sensing and parathyroid hormone-1 receptors, respectively...
October 25, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29080462/effect-of-broccoli-sprouts-on-thyroid-function-haematological-biochemical-and-immunological-parameters-in-rats-with-thyroid-imbalance
#20
Paweł Paśko, Mirosław Krośniak, Ewelina Prochownik, Małgorzata Tyszka-Czochara, Maria Fołta, Renata Francik, Jakub Sikora, Mateusz Malinowski, Paweł Zagrodzki
Broccoli sprouts may exert a negative influence on thyroid function as they are a rich source of glucosinolates, in particular glucoraphanin. Under the study in a long-term experiment broccoli sprouts were tested as an element of rats diet, combined with deficient iodine, or sulfadimethoxine ingestion - two models of hypothyroidism. Evaluations were performed for serum TSH and thyroid hormones completed with analyzes of selected haematological, biochemical and immunological (IL-6, IL-10) parameters, as well as cytosolic glutathione peroxidase (GPX1), thioredoxin reductase (TR) in the thyroid, and plasma glutathione peroxidase (GPX3)...
October 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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