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https://www.readbyqxmd.com/read/29667662/camel-milk-attenuates-methotrexate-induced-kidney-injury-via-activation-of-pi3k-akt-enos-signaling-and-intervention-with-oxidative-aberrations
#1
Hany H Arab, Samir A Salama, Ibrahim A Maghrabi
Methotrexate (MTX) is a classical chemotherapeutic agent with nephrotoxicity as the most disturbing adverse effect. So far, its underlying molecular mechanisms, particularly PI3K/Akt/eNOS transduction, are inadequately explored. Several antioxidant modalities have been characterized to ameliorate MTX-induced renal injury. In this regard, Camel milk (CM) is a natural product with recognized antioxidant and anti-inflammatory features. Thus, the current study aimed to investigate the potential ameliorating effects of CM in MTX-induced kidney injury in rats...
April 18, 2018: Food & Function
https://www.readbyqxmd.com/read/29665653/upregulation-of-ppar-%C3%AE-mediates-the-renoprotective-effect-of-omega-3-pufa-and-ferulic-acid-in-gentamicin-intoxicated-rats
#2
Nahla E El-Ashmawy, Naglaa F Khedr, Hoda A El-Bahrawy, Sara A Helal
Ferulic acid (FrA) is a natural product containing phenolic compounds. ω-3 PUFA is the major constituent of fish oil. The aim of this study was to investigate the renoprotective role of FrA and FO in gentamicin (GM)-induced nephrotoxicity in rats. Forty four male rats were divided equally into 4 groups: Control group, GM group, FrA + GM group and FO + GM group. Each of the treated groups was injected with GM (40 mg/kg) i.p. for 9 consecutive days. FrA (100 mg/kg) and FO (5 mL/kg) were given to rats orally daily for 10 days prior to GM and then concomitantly with GM for additional 9 days...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29665445/acute-kidney-injury-during-treatment-with-high-dose-cloxacillin-a-report-of-23-cases-and-literature-review
#3
Aurélie Lavergne, Cécile Vigneau, Elisabeth Polard, Louise Triquet, Nathalie Rioux-Leclercq, Pierre Tattevin, Léonard Golbin
BACKGROUND: International guidelines recommend high-dose cloxacillin for endocarditis or osteoarticular infections due to meticillin-susceptible staphylococci. However, data on the tolerability of these regimens are scarce. METHODS: We used the computerized registry of suspected drug-related adverse events in our institution. Cases of acute kidney injury (AKI), as defined by KDIGO, in patients receiving high-dose cloxacillin, were retrospectively reviewed. Data were collected from medical charts on a standardized questionnaire...
April 14, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29661544/renal-cell-carcinoma-for-the-nephrologist
#4
REVIEW
Mark A Perazella, Robert Dreicer, Mitchell H Rosner
Renal cell carcinoma (RCC), a malignancy whose incidence is increasing, is frequently encountered in general nephrology practice when acute and chronic kidney disease occurs in the course of disease. Importantly, when kidney disease develops in the setting of RCC, mortality is significantly increased with patients often dying of a non-cancer-related complication of kidney disease. As such, practicing nephrologists need to have a working knowledge of this cancer's biology, treatment, and complications. Nephrologists should be involved in all aspects of the care of patients with RCC including in the acute setting prior to nephrectomy and in the chronic setting for patients with post-nephrectomy chronic kidney disease and those receiving potentially nephrotoxic anti-cancer agents...
April 13, 2018: Kidney International
https://www.readbyqxmd.com/read/29658769/multimodality-imaging-assessment-of-endoleaks-post-endovascular-aortic-repair
#5
Sasan Partovi, Thomas Trischman, Vasileios Rafailidis, Suvranu Ganguli, Fabian Rengier, Harold Goerne, Prabhakar Rajiah, Daniel Staub, Indravadan J Patel, George Oliveira, Brian Ghoshhajra
Endoleaks are a common complication of endovascular aortic repair (EVAR). As a result, patients require lifelong imaging surveillance following EVAR. In current clinical practice evaluation for endoleaks is predominantly performed with computed tomography angiography (CTA). Due to the significant cumulative radiation burden associated with repetitive CTA imaging, as well as the repeated administration of nephrotoxic contrast agent, contrast-enhanced ultrasound (CEUS) and magnetic resonance angiography (MRA) have evolved as potential modalities for lifelong surveillance post-EVAR...
April 16, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29658347/contrast-enhanced-ultrasound-ceus-imaging-of-solid-benign-focal-liver-lesions
#6
Christoph F Dietrich, Claudio Tana, Cosmin Caraiani, Yi Dong
Ultrasound is well accepted worldwide for imaging of the liver. Absences of radiation exposure, low cost and large diffusion are some of the advantages that make this technique the first to be used in the assessment of focal liver lesions (FLL). Areas covered: Contrast enhanced ultrasound (CEUS) has been introduced more than twenty years ago, and its detection rate is comparable to that of contrast enhanced magnetic resonance imaging (CEMRI) and contrast enhanced computed tomography (CECT). In this narrative review, we discuss the main CEUS features of benign liver lesions and controversies in published results including the gold standard chosen and the quality and knowledge of the preferred techniques...
April 16, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29657939/cisplatin-alters-sodium-excretion-and-renal-clearance-in-rats-gender-and-drug-dose-related
#7
Sima Jilanchi, Ardeshir Talebi, Mehdi Nematbakhsh
Background: Nephrotoxicity is one of the side effects of cisplatin (CP) therapy which is gender related. CP disturbs renal function through glomerular filtration rate and electrolytes transport disturbances. This study was designed to compare some markers related to renal function in two protocols of CP treatment in rats. Materials and Methods: Male and female rats were subjected to receive single (treat 1; 7.5 mg/kg) and continues doses (treat 2; 3 mg/kg/day for 5 days) of CP, and the measurements were compared with control animals...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29651144/sirtuin-7-deficiency-ameliorates-cisplatin-induced-acute-kidney-injury-through-regulation-of-the-inflammatory-response
#8
Yoshikazu Miyasato, Tatsuya Yoshizawa, Yoshifumi Sato, Terumasa Nakagawa, Yuko Miyasato, Yutaka Kakizoe, Takashige Kuwabara, Masataka Adachi, Alessandro Ianni, Thomas Braun, Yoshihiro Komohara, Masashi Mukoyama, Kazuya Yamagata
Cisplatin-induced acute kidney injury (AKI) has been recognized as one of cisplatin's serious side effects, limiting its use in cancer therapy. Sirtuin 1 (SIRT1) and SIRT3 play protective roles against cisplatin-induced kidney injury. However, the role of SIRT7 in cisplatin-induced kidney injury is not yet known. In this study, we found that Sirt7 knockout (KO) mice were resistant to cisplatin-induced AKI. Furthermore, our studies identified that loss of SIRT7 decreases the expression of tumor necrosis factor-α (TNF-α) by regulating the nuclear expression of the transcription factor nuclear factor kappa B...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29649586/nephrotoxicity-of-piperacillin-tazobactam-combined-with-vancomycin-should-it-be-a-concern
#9
Cafer Balcı, Ömrüm Uzun, Mustafa Arıcı, Sibel Aşçıoğlu Hayran, Deniz Yüce, Serhat Ünal
The combination of piperacillin-tazobactam (pip-tazo) and vancomycin provides a wide spectrum of activity against many pathogens acquired in the health-care setting. However, there have been reports of increased potential for nephrotoxicity with this combination. The aim of this study was to evaluate the nephrotoxic effect of pip-tazo plus vancomycin and compare it with that of pip-tazo and vancomycin alone, and meropenem plus vancomycin, another broad-spectrum combination. A total of 402 patients receiving either antimicrobial regimen for more than 48 hours were evaluated retrospectively in a two-year period...
April 9, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29643981/nephroprotective-effect-of-sonchus-oleraceus-extract-against-kidney-injury-induced-by-ischemia-reperfusion-in-wistar-rats
#10
Liliana Torres-González, Eduardo Cienfuegos-Pecina, Marlene M Perales-Quintana, Gabriela Alarcon-Galvan, Linda E Muñoz-Espinosa, Edelmiro Pérez-Rodríguez, Paula Cordero-Pérez
Introduction: Kidney ischemia-reperfusion (I/R) injury is the main cause of delayed graft function in solid organ transplantation. Sonchus oleraceus is a plant with well-known antioxidant and anti-inflammatory activities; however, its effects on renal I/R are unknown. Objective: To evaluate whether S. oleraceus extract (S.O.e.) has nephroprotective activity in an I/R model in Wistar rats. Materials and Methods: Animal groups ( n = 6): sham, I/R (45 min/15 h), S...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29642900/cisplatin-based-therapy-the-role-of-the-mitogen-activated-protein-kinase-signaling-pathway
#11
REVIEW
Iman W Achkar, Nabeel Abdulrahman, Hend Al-Sulaiti, Jensa Mariam Joseph, Shahab Uddin, Fatima Mraiche
Cisplatin is a widely used chemotherapeutic agent for treatment of various cancers. However, treatment with cisplatin is associated with drug resistance and several adverse side effects such as nephrotoxicity, reduced immunity towards infections and hearing loss. A Combination of cisplatin with other drugs is an approach to overcome drug resistance and reduce toxicity. The combination therapy also results in increased sensitivity of cisplatin towards cancer cells. The mitogen activated protein kinase (MAPK) pathway in the cell, consisting of extracellular signal regulated kinase, c-Jun N-terminal kinase, p38 kinases, and downstream mediator p90 ribosomal s6 kinase (RSK); is responsible for the regulation of various cellular events including cell survival, cell proliferation, cell cycle progression, cell migration and protein translation...
April 11, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29642744/evaluation-of-continuous-infusion-vancomycin-administration-in-a-critically-ill-trauma-population
#12
Brittany D Bissell, Gina Riggi, Christopher Morrison
Vancomycin is a first-line antibiotic for empiric treatment of gram-positive infections in the trauma intensive care unit. When dosed intermittently, difficulties arise from trough collection and drug monitoring. The objective of this study was to evaluate time to goal vancomycin levels comparing a continuous infusion protocol when compared to standard intermittent infusion dosing. This was a retrospective cohort of patients admitted to the trauma intensive care unit between July 2011 and July 2015 receiving vancomycin for at least 48 hours...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29642731/the-effect-of-hemodynamically-significant-patent-ductus-arteriosus-on-acute-kidney-injury-and-systemic-hypertension-in-extremely-low-gestational-age-newborns
#13
Danitza M Velazquez, Kimberly J Reidy, Madhu Sharma, Mimi Kim, Melissa Vega, Tomas Havranek
BACKGROUND: Acute kidney injury (AKI) in preterm neonates is becoming an increasingly recognized morbidity in the neonatal intensive care unit neonatal intensive care unit (NICU), yet its epidemiology, delineation and relation to numerous toxic exposures and common morbidities such as systemic hypertension is just evolving. With a frequency of the patent ductus arteriosus (PDA) as high as 70% in preterm infants born before 28-week gestation, the role of the hemodynamically significant PDA (hs-PDA) remains unclear...
April 12, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29642519/beneficial-effects-of-bioactive-compounds-in-mulberry-fruits-against-cisplatin-induced-nephrotoxicity
#14
Dahae Lee, Jae Sik Yu, Seoung Rak Lee, Gwi Seo Hwang, Ki Sung Kang, Jae Gyu Park, Hyun Young Kim, Ki Hyun Kim, Noriko Yamabe
Mulberry, the fruit of white mulberry tree ( Morus alba L., Moraceae), is commonly used in traditional Chinese medicines as a sedative, tonic, laxative, and emetic. In our continuing research of the bioactive metabolites from mulberry, chemical analysis of the fruits led to the isolation of five compounds, 1 - 5 . The compounds were identified as butyl pyroglutamate ( 1 ), quercetin 3- O -β-d-glucoside ( 2 ), kaempferol 3- O -β-d-rutinoside ( 3 ), rutin ( 4 ), and 2-phenylethyl d-rutinoside ( 5 ) by spectroscopic data analysis, comparing their nuclear magnetic resonance (NMR) data with those in published literature, and liquid chromatography-mass spectrometry analysis...
April 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29629666/clinical-significance-of-anti-ribosomal-p-protein-antibodies-in-patients-with-lupus-nephritis
#15
Sabahat Sarfaraz, Sabiha Anis, Ejaz Ahmed, Rana Muzaffar
BACKGROUND: Systemic lupus erythematosus (SLE) is achronic inflammatory disorder affecting multiplesystems of the body. Clinical features show wide variations in patients with different ethnic background. Renal involvement is a predictor of poor prognosis. Immunological workup is an integral part of SLE diagnostic criteria. Anti-ribosomal P Protein (anti-P) antibodies are highly specific for SLE. They may be present inantinuclear antibodies (ANA) negative SLE patients. Their role in lupus nephritis (LN) is under debate, some researchers found them associated with poor prognosiswhereasothers found favorable effect of these antibodies on renal disease...
April 9, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29627381/restorative-effect-of-l-dopa-treatment-against-ochratoxin-a-induced-neurotoxicity
#16
Pratiksha V Bhat, T Anand, Manu T Mohan, Farhath Khanum
The toxic effects of Ochratoxin A (OTA), a fungal secondary metabolite of the genera Aspergillus and Penicillium with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) a Parkinson inducing drug were investigated to evaluate the neurotoxic effects exerted by OTA. OTA is known to contaminate food and feedstuff leading to a wide range of toxicity like nephrotoxicity, hepatotoxicity, and immunotoxicity. However, due to the dearth of available information on the possible mechanisms of OTA neurotoxicity and neurodegeneration the current study was undertaken...
April 5, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29626199/advances-in-predictive-in-vitro-models-of-drug-induced-nephrotoxicity
#17
REVIEW
Joanne Y-C Soo, Jitske Jansen, Rosalinde Masereeuw, Melissa H Little
No abstract text is available yet for this article.
April 6, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29623832/herbs-with-potential-nephrotoxic-effects-according-to-traditional-persian-medicine-review-and-assessment-of-scientific-evidence
#18
Fatemeh Kolangi, Zahra Memariani, Mahboubeh Bozorgi, Seyyed Ali Mozaffarpur, Mohaddeseh Mirzapour
BACKGROUND: The increased use of herbal remedies particularly in patients with kidney diseases indicated the importance of studies which focused on nephrotoxic plants. OBJECTIVE: The present study aimed to review and assess the kidney-damaging herbs mentioned in the Persian medicine [PM] books. METHODS: The main PM books were searched for nephrotoxic herbs and their relevant reformers traditionally proposed for preventing renal damage. PubMed, Scopus and Google Scholar were investigated for evaluation of the scientific evidence relating to the nephrotoxicity of herbs...
April 3, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29622670/pharmacology-behind-common-drug-nephrotoxicities
#19
Mark A Perazella
Patients are exposed to numerous prescribed and over-the-counter medications. Unfortunately, drugs remain a relatively common cause of acute and chronic kidney injury. A combination of factors including the innate nephrotoxicity of drugs, underlying patient characteristics that increase their risk for kidney injury, and the metabolism and pathway of excretion by the kidneys of the various agents administered enhance risk for drug-induced nephrotoxicity. This paper will review these clinically relevant aspects of drug-induced nephrotoxicity for the clinical nephrologist...
April 5, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29622668/utility-of-electronic-medical-record-alerts-to-prevent-drug-nephrotoxicity
#20
Melissa Martin, F Perry Wilson
Nephrotoxin-induced AKI is an iatrogenic form of AKI that can be potentially avoided or ameliorated by prompt recognition and appropriate prescriber actions. Drug-targeted alerts, either for patients at risk of AKI or patients with existing AKI, may lead to more appropriate drug dosing and management and improved clinical outcomes. However, alerts of this type are complicated to create, have a high potential for error and off-target effects, and may be difficult to evaluate. Although many studies have shown that these alerts can reduce the rate of inappropriate prescribing, few studies have examined the utility of such alerts in terms of patient benefit...
April 5, 2018: Clinical Journal of the American Society of Nephrology: CJASN
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