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https://www.readbyqxmd.com/read/29676757/arsenic-cadmium-lead-and-chromium-in-well-water-rice-and-human-urine-in-sri-lanka-in-relation-to-chronic-kidney-disease-of-unknown-etiology
#1
H M Ayala S Herath, Tomonori Kawakami, Shiori Nagasawa, Yuka Serikawa, Ayuri Motoyama, G G Tushara Chaminda, S K Weragoda, S K Yatigammana, A A G D Amarasooriya
Chronic kidney disease of unknown etiology (CKDu) is spreading gradually in Sri Lanka. In the current research, 1,435 well water samples from all 25 districts of Sri Lanka, 91 rice samples, and 84 human urine samples from both CKDu-endemic and non-endemic areas in Sri Lanka were analyzed for arsenic, cadmium, lead, and chromium to detect whether toxic elements could be a cause of CKDu. The liver-type fatty acid binding protein (L-FABP) concentration and arsenic, cadmium, lead, and chromium concentrations of the urine samples were analyzed to determine the relation of L-FABP with arsenic, cadmium, lead, and chromium...
April 2018: Journal of Water and Health
https://www.readbyqxmd.com/read/29513702/morphological-and-clinical-findings-in-sri-lankan-patients-with-chronic-kidney-disease-of-unknown-cause-ckdu-similarities-and-differences-with-mesoamerican-nephropathy
#2
Julia Wijkström, Channa Jayasumana, Rajeewa Dassanayake, Nalin Priyawardane, Nimali Godakanda, Sisira Siribaddana, Anneli Ring, Kjell Hultenby, Magnus Söderberg, Carl-Gustaf Elinder, Annika Wernerson
In Sri Lanka, an endemic of chronic kidney disease of unknown origin (CKDu) is affecting rural communities. The endemic has similarities with Mesoamerican Nephropathy (MeN) in Central America, however it has not yet been clarified if the endemics are related diagnostic entities. We designed this study of kidney biopsies from patients with CKDu in Sri Lanka to compare with MeN morphology. Eleven patients with CKDu were recruited at the General Hospital, Polonnaruwa, using similar inclusion and exclusion criteria as our previous MeN studies...
2018: PloS One
https://www.readbyqxmd.com/read/29421748/impact-of-a-commercial-glyphosate-formulation-on-adsorption-of-cd-ii-and-pb-ii-ions-on-paddy-soil
#3
T Divisekara, A N Navaratne, A S K Abeysekara
Use of glyphosate as a weedicide on rice cultivation has been a controversial issue in Sri Lanka, due to the hypothesis that the metal complexes of commercial glyphosate is one of the causative factors of Chronic Kidney Disease of unknown aetiology (CKDu) prevalent in some parts of Sri Lanka. The effect of commercial glyphosate on the adsorption and desorption of Cd(II) and Pb(II) ions on selective paddy soil studied using batch experiments, over a wide concentration range, indicates that the Langmuir adsorption isotherm model is obeyed at low initial metal ion concentrations while the Freundlich adsorption isotherm model obeys at high metal ion concentrations in the presence and absence of glyphosate...
February 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29390596/novel-urinary-biomarkers-and-their-association-with-urinary-heavy-metals-in-chronic-kidney-disease-of-unknown-aetiology-in-sri-lanka-a-pilot-study
#4
K Wanigasuriya
Introduction: Chronic kidney disease of unknown etiology (CKDu) has emerged as a significant public health problem in Sri Lanka. The role of environmental exposure to cadmium and arsenic in the aetiology of CKDu is still unclear. Identification of a panel of novel urinary biomarkers would be invaluable in the study of toxin mediated damage postulated to be the aetiology of CKDu. Objectives: The aims of this study were to evaluate the profile of novel urinary biomarkers in CKDu patients and identify any association with environmental exposure to heavy metals...
December 26, 2017: Ceylon Medical Journal
https://www.readbyqxmd.com/read/29165145/organochlorine-pesticide-level-in-patients-with-chronic-kidney-disease-of-unknown-etiology-and-its-association-with-renal-function
#5
Rishila Ghosh, Manushi Siddarth, Neeru Singh, Vipin Tyagi, Pawan Kumar Kare, Basu Dev Banerjee, Om Prakash Kalra, Ashok Kumar Tripathi
BACKGROUND: Involvement of agrochemicals have been suggested in the development of chronic kidney disease of unknown etiology (CKDu). The association between CKDu and blood level of organochlorine pesticides (OCPs) in CKDu patients has been examined in the present study. METHODS: All the recruited study subjects (n = 300) were divided in three groups, namely, healthy control (n = 100), patients with chronic kidney disease of unknown etiology (n = 100), and patients with chronic kidney disease of known etiology (CKDk) (n = 100)...
May 26, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/28965591/tracing-environmental-aetiological-factors-of-chronic-kidney-diseases-in-the-dry-zone-of-sri-lanka-a-hydrogeochemical-and-isotope-approach
#6
Sudeera Wickramarathna, Shyamalie Balasooriya, Saranga Diyabalanage, Rohana Chandrajith
Chronic kidney disease of unknown aetiologies (CKDu) is increasingly recognized in tropical regions and is now considered a global health problem. A detailed hydrogeochemical investigation has been performed in three CKDu hotspots in Sri Lanka to assess the geo-environmental aetiological factors influencing this disease. A total of 71 ground- and 26 surface water samples were collected from Girandurukotte, Wilgamuwa and Nikawewa regions and analysed for major constituents and trace elements. The affected regions are dominated by Ca-Mg-HCO3 facies groundwater that is mainly controlled by silicate weathering...
December 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28948847/geochemical-and-isotopic-evidences-from-groundwater-and-surface-water-for-understanding-of-natural-contamination-in-chronic-kidney-disease-of-unknown-etiology-ckdu-endemic-zones-in-sri-lanka
#7
E A N V Edirisinghe, H Manthrithilake, H M T G A Pitawala, H A Dharmagunawardhane, R L Wijayawardane
Chronic kidney disease of unknown etiology (CKDu) is the main health issue in the dry zone of Sri Lanka. Despite many studies carried out, causative factors have not been identified yet clearly. According to the multidisciplinary researches carried out so far, potable water is considered as the main causative factor for CKDu. Hence, the present study was carried out with combined isotopic and chemical methods to understand possible relationships between groundwater; the main drinking water source, and CKDu in four endemic areas in the dry zone...
September 26, 2017: Isotopes in Environmental and Health Studies
https://www.readbyqxmd.com/read/28926845/leptospirosis-renal-disease-emerging-culprit-of-chronic-kidney-disease-unknown-etiology
#8
Chih-Wei Yang
Leptospirosis is the most prevalent zoonosis affecting more than 1 million populations worldwide. Interestingly, leptospirosis endemic regions coincide with chronic kidney disease (CKD) hotspots largely due to flooding and agricultural overlaps. Acute leptospirosis induces multiple organ dysfunction including acute kidney injury and may predispose to CKD and end-stage renal disease, if not treated timely. Asymptomatic infection may carry the bacteria in the kidney and CKD progresses insidiously. Histologic finding of leptospirosis renal disease includes tubulointerstitial nephritis, interstitial fibrosis, and tubular atrophy...
2018: Nephron
https://www.readbyqxmd.com/read/28864964/chronic-kidney-disease-of-unknown-etiology-and%C3%A2-the-effect-of-multiple-ion-interactions
#9
M W C Dharma-Wardana
High incidence of chronic kidney disease of unknown etiology (CKDU) prevalent in many countries (e.g., Sri Lanka, equatorial America) is reviewed in the context of recent experimental work and using our understanding of the hydration of ions and proteins. Qualitative considerations based on Hofmeister-type action of these ions, as well as quantitative electrochemical models for the Gibbs free energy change for ionpair formation, are used to explain why (1) fluoride and water hardness due to magnesium ions (but not due to calcium ions) and similarly (2) cadmium ions in the presence of suitable pairing ions can be expected to be more nephrotoxic, while arsenite in the presence of fluoride and hardness may be expected to be less nephrotoxic...
September 1, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28842062/ajkd-atlas-of-renal-pathology-ckd-of-unknown-cause-ckdu-mesoamerican-nephropathy
#10
Mark A Lusco, Agnes B Fogo, Annika Östman Wernerson, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
September 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28666453/beginning-of-a-journey-unraveling-the-mystery-of-chronic-kidney-disease-of-unknown-aetiology-ckdu-in-sri-lanka
#11
Jacob Kumaresan, Ruwanika Seneviratne
BACKGROUND: Globally, chronic kidney disease of unknown aetiology (CKDu) is observed in several areas and among specific ethnic or occupational groups. Given the widespread environmental pollution and the proportions of agriculture workers world-wide, CKDu may be the next global public health issue demanding attention. Recent escalation of CKDu in Sri Lanka has caused a serious public health crisis in the country, made worse by lack of national data. MAIN TEXT: The specific geographic distribution, preponderance among farming population, similar histology findings and absence of usual risk factors for kidney disease indicate undetected nephrotoxic agents playing a role in causation...
June 30, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28629425/screening-for-chronic-kidney-disease-of-uncertain-aetiology-in-sri-lanka-usability-of-surrogate-biomarkers-over-dipstick-proteinuria
#12
Samantha Ratnayake, Zeid Badurdeen, Nishantha Nanayakkara, Tilak Abeysekara, Neelakanthi Ratnatunga, Ranjith Kumarasiri
BACKGROUND: The use of dipstick proteinuria to screen Chronic Kidney Disease of uncertain aetiology (CKDu) in Sri Lanka is a recently debated matter of dispute. The aim of this study was to assess the suitability of biomarkers: serum creatinine, cystatin C and urine albumin to creatinine ratio (ACR) for screening CKDu in Sri Lanka. METHODS: Forty-four male CKDu patients and 49 healthy males from a CKDu-endemic region were selected. Meanwhile, 25 healthy males from a non-endemic region were selected as an absolute control...
June 19, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28535811/pesticide-exposures-and-chronic-kidney-disease-of-unknown-etiology-an-epidemiologic-review
#13
REVIEW
Mathieu Valcke, Marie-Eve Levasseur, Agnes Soares da Silva, Catharina Wesseling
The main causes of chronic kidney disease (CKD) globally are diabetes and hypertension but epidemics of chronic kidney disease of unknown etiology (CKDu) occur in Central America, Sri Lanka, India and beyond. Althoug also being observed in women, CKDu concentrates among men in agricultural sectors. Therefore, suspicions fell initially on pesticide exposure, but currently chronic heat stress and dehydration are considered key etiologic factors. Responding to persistent community and scientific concerns about the role of pesticides, we performed a systematic review of epidemiologic studies that addressed associations between any indicator of pesticide exposure and any outcome measure of CKD...
May 23, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28394638/bio-media-citizenship-and-chronic-kidney-disease-of-unknown-etiology-in-sri-lanka
#14
M W Amarasiri de Silva
In this article, I examine the crucial role of the biomedical industry, epidemiological and biomedical research, and the media in forming attitudes to and the understanding of chronic kidney disease of unknown etiology (CKDu) in Sri Lanka. Local conceptions of CKDu have been shaped by the circulation in the media of epidemiological research findings pertaining to the disease, biomedical interventions in the management of the disease in hospitals and clinics, community programs involving mass blood surveys and the testing of well water, and local food and health education programs carried out through village health committees...
April 10, 2017: Medical Anthropology
https://www.readbyqxmd.com/read/28390327/ingestion-of-dug-well-water-from-an-area-with-high-prevalence-of-chronic-kidney-disease-of-unknown-etiology-ckdu-and-development-of-kidney-and-liver-lesions-in-rats
#15
M G Thammitiyagodage, M M Gunatillaka, N Ekanayaka, C Rathnayake, N U Horadagoda, R Jayathissa, U K Gunaratne, W G Kumara, P Abeynayake
Introduction: Chronic kidney disease of unknown aetiology (CKDu) is prevalent in the North Central Province (NCP) of Sri Lanka and ingestion of dug well water is considered a potential causative factor. Three CKDu prevalent villages were selected from the NCP based on the number of CKDu patients in the locality. Methods: Forty Wistar rats were divided into four groups with 10 rats each. Group No 1, 2 and 3 were given water from selected dug wells. Control group was given tap water from Colombo...
March 31, 2017: Ceylon Medical Journal
https://www.readbyqxmd.com/read/28370958/diminished-disease-progression-rate-in-a-chronic-kidney-disease-population-following-the-replacement-of-dietary-water-source-with-quality-drinking-water-a-pilot-study
#16
Edirisinghe Arachchige Ranga Iroshanie Edirisinghe Siriwardhana, Ponnamperuma Aratchige Jayasumana Perera, Ramiah Sivakanesan, Tilak Abeysekara, Danaseela Bandara Nugegoda, Kosala Weerakoon, Dunusingha Asitha Surandika Siriwardhana
AIM: Environmental toxin/s is alleged to be the contributory factor for the chronic kidney disease of unknown etiology (CKDu) in Sri Lanka. The potential of drinking water as a medium for the nephrotoxic agents in the affected subjects has been comprehensively discoursed in the recent past. The present study was aimed to assess the effect of replacing the habitual drinking water on the kidney function of CKDu patients residing in the North Central Province of Sri Lanka: METHODS: An interventional study was carried out to assess the disease progression rate of a CKDu population whose habitual drinking water was replaced by bottled spring water certified by Sri Lanka Standard (SLS) for a period of 18 month along with a population of CKDu patients who continued with their usual drinking water...
March 29, 2017: Nephrology
https://www.readbyqxmd.com/read/28367535/endemic-nephropathy-around-the-world
#17
REVIEW
Fiona J Gifford, Robert M Gifford, Michael Eddleston, Neeraj Dhaun
There have been several global epidemics of chronic kidney disease of unknown etiology (CKD u ). Some, such as Itai-Itai disease in Japan and Balkan endemic nephropathy, have been explained, whereas the etiology of others remains unclear. In countries such as Sri Lanka, El Salvador, Nicaragua, and India, CKD u is a major public health problem and causes significant morbidity and mortality. Despite their geographical separation, however, there are striking similarities between these endemic nephropathies. Young male agricultural workers who perform strenuous labor in extreme conditions are the worst affected...
March 2017: KI Reports
https://www.readbyqxmd.com/read/28292724/deleterious-role-of-trace-elements-silica-and-lead-in-the-development-of-chronic-kidney-disease
#18
Starlaine Mascarenhas, Srikanth Mutnuri, Anasuya Ganguly
Chronic-Kidney-Disease of Unknown-etiology (CKDu) has been reported in developing-countries like Sri-Lanka, India and Central-America without sparing the Indian sub-district (namely Canacona) located in south-Goa. The disease etiology is unlinked to common causes of diabetes and hypertension and assumed to be environmentally induced due to its asymptomatic-nature and occurrence in groundwater relying communities. This study aimed to understand environmental risk-factors underlying CKDu-etiology using Indian sub-district (Canacona) as case-study...
June 2017: Chemosphere
https://www.readbyqxmd.com/read/28289987/biochar-based-constructed-wetlands-to-treat-reverse-osmosis-rejected-concentrates-in-chronic-kidney-disease-endemic-areas-in-sri-lanka
#19
B C L Athapattu, T W L R Thalgaspitiya, U L S Yasaratne, Meththika Vithanage
The objectives were to investigate the potential remedial measures for reverse osmosis (RO) rejected water through constructed wetlands (CWs) with low-cost materials in the media established in chronic kidney disease of unknown etiology (CKDu) prevalent area in Sri Lanka. A pilot-scale surface and subsurface water CWs were established at the Medawachchiya community-based RO water supply unit. Locally available soil, calicut tile and biochar were used in proportions of 81, 16.5 and 2.5% (w/w), respectively, as filter materials in the subsurface...
December 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28237863/structural-violence-and-chronic-kidney-disease-of-unknown-etiology-in-sri-lanka
#20
M W Amarasiri de Silva, Steven M Albert, J M K B Jayasekara
Research published on Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka has been undertaken largely from biomedical and epidemiological perspectives. The main objective of these studies has been to identify the etiology of the disease, which affects as much as 15-21% of the population in some regions and is associated with kidney failure. Few studies have sought to address how CKDu is socially and behaviorally situated in the affected districts. The present study, informed by structural violence theory, utilized a mixed-method approach that analyzed primary and secondary data for Medawachchiya District Secretariat Division in Anuradhapura District for 2010 and 2015, and examined CKDu as a manifestation of social inequality and exclusion and the creation of a marginalized group of agricultural laborers...
April 2017: Social Science & Medicine
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