Carlos A Roncal-Jimenez, Keegan L Rogers, Arthur Stem, Julia Wijkstrom, Annika Wernerson, Jacob Fox, Ramon Garcia Trabanino, Stephen Brindley, Gabriela Garcia, Makoto Miyazaki, Shinobu Miyazaki-Anzai, Fumihiko Sasai, Manuel Urra, Gabriel Cara-Fuentes, L Gabriela Sánchez-Lozada, Bernardo Rodriguez-Iturbe, Jaime Butler Dawson, Magdalena Madero, Jared M Brown, Richard J Johnson
Background. Silica nanoparticles found in sugarcane ash have been postulated to be a toxicant contributing to chronic kidney disease of unknown etiology (CKDu). However, while the administration of manufactured silica nanoparticles is known to cause chronic tubulointerstitial disease in rats, the effect of administering sugarcane ash on kidney pathology remains unknown. Here we investigate whether sugarcane ash can induce CKD in rats. Methods . Sugarcane ash was administered for 13 weeks into the nares of rats (5 mg/day for 5d/week), and blood, urine and kidney tissues were collected at 13 weeks (at the end of ash administration) and in a separate group of rats at 24 weeks (11 weeks after stopping ash administration)...
January 18, 2024: American Journal of Physiology. Renal Physiology