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https://www.readbyqxmd.com/read/28292724/deleterious-role-of-trace-elements-silica-and-lead-in-the-development-of-chronic-kidney-disease
#1
Starlaine Mascarenhas, Srikanth Mutnuri, Anasuya Ganguly
Chronic-Kidney-Disease of Unknown-etiology (CKDu) has been reported in developing-countries like Sri-Lanka, India and Central-America without sparing the Indian sub-district (namely Canacona) located in south-Goa. The disease etiology is unlinked to common causes of diabetes and hypertension and assumed to be environmentally induced due to its asymptomatic-nature and occurrence in groundwater relying communities. This study aimed to understand environmental risk-factors underlying CKDu-etiology using Indian sub-district (Canacona) as case-study...
March 1, 2017: Chemosphere
https://www.readbyqxmd.com/read/28289987/biochar-based-constructed-wetlands-to-treat-reverse-osmosis-rejected-concentrates-in-chronic-kidney-disease-endemic-areas-in-sri-lanka
#2
B C L Athapattu, T W L R Thalgaspitiya, U L S Yasaratne, Meththika Vithanage
The objectives were to investigate the potential remedial measures for reverse osmosis (RO) rejected water through constructed wetlands (CWs) with low-cost materials in the media established in chronic kidney disease of unknown etiology (CKDu) prevalent area in Sri Lanka. A pilot-scale surface and subsurface water CWs were established at the Medawachchiya community-based RO water supply unit. Locally available soil, calicut tile and biochar were used in proportions of 81, 16.5 and 2.5% (w/w), respectively, as filter materials in the subsurface...
March 13, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28237863/structural-violence-and-chronic-kidney-disease-of-unknown-etiology-in-sri-lanka
#3
M W Amarasiri de Silva, Steven M Albert, J M K B Jayasekara
Research published on Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka has been undertaken largely from biomedical and epidemiological perspectives. The main objective of these studies has been to identify the etiology of the disease, which affects as much as 15-21% of the population in some regions and is associated with kidney failure. Few studies have sought to address how CKDu is socially and behaviorally situated in the affected districts. The present study, informed by structural violence theory, utilized a mixed-method approach that analyzed primary and secondary data for Medawachchiya District Secretariat Division in Anuradhapura District for 2010 and 2015, and examined CKDu as a manifestation of social inequality and exclusion and the creation of a marginalized group of agricultural laborers...
April 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28103909/potential-diagnostic-biomarkers-for-chronic-kidney-disease-of-unknown-etiology-ckdu-in-sri-lanka-a-pilot-study
#4
Saravanabavan Sayanthooran, Dhammika N Magana-Arachchi, Lishanthe Gunerathne, Tilak Abeysekera
BACKGROUND: In Sri Lanka, there exists chronic kidney disease of both known (CKD) and unknown etiologies (CKDu). Identification of novel biomarkers that are customized to the specific causative factors would lead to early diagnosis and clearer prognosis of the diseases. This study aimed to find genetic biomarkers in blood to distinguish and identify CKDu from CKD as well as healthy populations from CKDu endemic and non-endemic areas of Sri Lanka. METHODS: The expression patterns of a selected panel of 12 potential genetic biomarkers were analyzed in blood using RT-qPCR...
January 19, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28049448/international-collaboration-for-the-epidemiology-of-egfr-in-low-and-middle-income-populations-rationale-and-core-protocol-for-the-disadvantaged-populations-egfr-epidemiology-study-degree
#5
Ben Caplin, Kristina Jakobsson, Jason Glaser, Dorothea Nitsch, Vivekanand Jha, Ajay Singh, Ricardo Correa-Rotter, Neil Pearce
BACKGROUND: There is an increasing recognition of epidemics of primarily tubular-interstitial chronic kidney disease (CKD) clustering in agricultural communities in low- and middle-income countries (LMICs). Although it is currently unclear whether there is a unified underlying aetiology, these conditions have been collectively termed CKD of undetermined cause (CKDu). CKDu is estimated to have led to the premature deaths of tens to hundreds of thousands of young men and women over the last 2 decades...
January 3, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/27975059/upregulation-of-oxidative-stress-related-genes-in-a-chronic-kidney-disease-attributed-to-specific-geographical-locations-of-sri-lanka
#6
Saravanabavan Sayanthooran, Dhammika N Magana-Arachchi, Lishanthe Gunerathne, Tilak D J Abeysekera, Suneth S Sooriyapathirana
Objective. To infer the influence of internal and external oxidative stress in chronic kidney disease patients of unknown etiology (CKDu) in Sri Lanka, by analyzing expression of genes related directly or indirectly to oxidative stress: glutamate-cysteine ligase catalytic subunit (GCLC), glutathione S-transferase mu 1 (GSTM1), glucose-6-phosphate dehydrogenase (G6PD), fibroblast growth factor-23 (FGF23), and NLR family pyrin domain containing 3 (NLRP3). Methods. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) was carried out for the selected populations: CKDu patients (n = 43), chronic kidney disease patients (CKD; n = 14), healthy individuals from a CKDu endemic area (GHI; n = 9), and nonendemic area (KHI; n = 16)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27908426/environmental-exposures-of-trace-elements-assessed-using-keratinized-matrices-from-patients-with-chronic-kidney-diseases-of-uncertain-etiology-ckdu-in-sri-lanka
#7
Saranga Diyabalanage, Sanjeewani Fonseka, D M S N B Dasanayake, Rohana Chandrajith
An alarming increase in chronic kidney disease with unknown etiology (CKDu) has recently been reported in several provinces in Sri Lanka and chronic exposures to toxic trace elements were blamed for the etiology of this disease. Keratinized matrices such as hair and nails were investigated to determine the possible link between CKDu and toxic element exposures. Elements Li, B, Al, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Sr, Mo, Cd, Ba, Hg and Pb of hair and nails of patients and age that matched healthy controls were determined with Inductively Coupled Plasma Mass Spectrometry (ICP-MS)...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27795631/clinicopathological-correlates-of-chronic-kidney-disease-of-unknown-etiology-in-sri-lanka
#8
M Selvarajah, P Weeratunga, S Sivayoganthan, N Rathnatunga, S Rajapakse
Chronic kidney disease of unknown etiology (CKDu) is a major healthcare issue in Sri Lanka. This study included 125 consecutive patients with a diagnosis of CKDu undergoing renal biopsy at one hospital from 2008 to 2012. Associations between renal outcome parameters, epidemiological data, and histopathological findings were examined and regression models constructed based on univariate associations with outcome variables as serum creatinine >1.2 and stage of CKD >3. The mean patient age was 46.21 years (standard deviation = 11...
September 2016: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/27643785/urinary-biomarkers-kim-1-and-ngal-for-detection-of-chronic-kidney-disease-of-uncertain-etiology-ckdu-among-agricultural-communities-in-sri-lanka
#9
Pallagae Mangala C S De Silva, Khaja Shameem Mohammed Abdul, Eakanayake M D V Eakanayake, Sudheera Sammanthi Jayasinghe, Channa Jayasumana, Hewa Bandulage Asanthi, Hettiarachigae S D Perera, Gamage G Tushara Chaminda, Ediriweera P S Chandana, Sisira H Siribaddana
Chronic Kidney Disease of uncertain etiology (CKDu) is an emerging epidemic among farming communities in rural Sri Lanka. Victims do not exhibit common causative factors, however, histopathological studies revealed that CKDu is a tubulointerstitial disease. Urine albumin or albumin-creatinine ratio is still being used as a traditional diagnostic tool to identify CKDu, but accuracy and prevalence data generated are questionable. Urinary biomarkers have been used in similar nephropathy and are widely recognised for their sensitivity, specificity and accuracy in determining CKDu and early renal injury...
September 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27591985/quest-to-identify-geochemical-risk-factors-associated-with-chronic-kidney-disease-of-unknown-etiology-ckdu-in-an-endemic-region-of-sri-lanka-a-multimedia-laboratory-analysis-of-biological-food-and-environmental-samples
#10
Keith E Levine, Jennifer Hoponick Redmon, Myles F Elledge, Kamani P Wanigasuriya, Kristin Smith, Breda Munoz, Vajira A Waduge, Roshini J Periris-John, Nalini Sathiakumar, James M Harrington, Donna S Womack, Rajitha Wickremasinghe
The emergence of a new form of chronic kidney disease of unknown etiology (CKDu) in Sri Lanka's North Central Province (NCP) has become a catastrophic health crisis. CKDu is characterized as slowly progressing, irreversible, and asymptomatic until late stages and, importantly, not attributed to diabetes, hypertension, or other known risk factors. It is postulated that the etiology of CKDu is multifactorial, involving genetic predisposition, nutritional and dehydration status, exposure to one or more environmental nephrotoxins, and lifestyle factors...
October 2015: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27586642/arterial-stiffness-sri-lankan-chronic-kidney-disease-of-unknown-origin
#11
Fiona Gifford, Robert Kimmitt, Chula Herath, David J Webb, Vanessa Melville, Sisira Siribaddana, Michael Eddleston, Neeraj Dhaun
Chronic kidney disease (CKD) is common and independently associated with cardiovascular disease (CVD). Arterial stiffness contributes to CVD risk in CKD. In many developing countries a considerable proportion of CKD remains unexplained, termed CKDu. We assessed arterial stiffness in subjects with Sri Lankan CKDu, in matched controls without CKD and in those with defined CKD. Aortic blood pressure (BP), pulse wave velocity (PWV) and augmentation index (AIx) were assessed in 130 subjects (50 with CKDu, 45 with CKD and 35 without CKD) using the validated TensioMed™ Arteriograph monitor...
September 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27469156/chronic-kidney-disease-of-uncertain-etiology-in-sri-lanka-is-a-possible-sequel-of-interstitial-nephritis
#12
Zeid Badurdeen, Nishantha Nanayakkara, Neelakanthi V I Ratnatunga, Abdul W M Wazil, Tilak D J Abeysekera, Premil N Rajakrishna, Jalitha P Thinnarachchi, Ranjith Kumarasiri, Dulani D Welagedera, Needika Rajapaksha, Adambarage P D Alwis
INTRODUCTION: The majority of published data on chronic kidney disease of uncertain etiology (CKDu) is on asymptomatic patients who were detected in screening programs. The clinicopathological profile of a group of patients presenting with acute symptoms and renal dysfunction from CKDu endemic regions in Sri Lanka was studied. METHODS: 59 patients > 10 years of age with backache, feverish fatigue feeling, dysuria, joint pain, or dyspepsia, singly or in combination with elevated serum creatinine (> 116 and > 98 µmol/L for male and females, respectively) were included in the study...
2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27399161/chronic-kidney-disease-of-unknown-etiology-in-sri-lanka
#13
Senaka Rajapakse, Mitrakrishnan Chrishan Shivanthan, Mathu Selvarajah
INTRODUCTION: In the last two decades, chronic kidney disease of unknown etiology (CKDu) has emerged as a significant contributor to the burden of chronic kidney disease (CKD) in rural Sri Lanka. It is characterized by the absence of identified causes for CKD. The prevalence of CKDu is 15.1-22.9% in some Sri Lankan districts, and previous research has found an association with farming occupations. METHODS: A systematic literature review in Pubmed, Embase, Scopus, and Lilacs databases identified 46 eligible peer-reviewed articles and one conference abstract...
July 11, 2016: International Journal of Occupational and Environmental Health
https://www.readbyqxmd.com/read/27142134/chronic-kidney-disease-of-uncertain-etiology-in-sri-lanka-are-leptospirosis-and-hantaviral-infection-likely-causes
#14
Chandika Damesh Gamage, Yomani Dilukshi Sarathkumara
Chronic kidney disease of uncertain etiology (CKDu) has been a severe burden and a public health crisis in Sri Lanka over the past two decades. Many studies have established hypotheses to identify potential risk factors although causative agents, risk factors and etiology of this disease are still uncertain. Several studies have postulated that fungal and bacterial nephrotoxins are a possible etiological factor; however, the precise link between hypothesized risk factors and the pathogenesis of chronic kidney disease has yet to be proven in prior studies...
June 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/26712810/ckd-of-uncertain-etiology-a-systematic-review
#15
REVIEW
Joseph Lunyera, Dinushika Mohottige, Megan Von Isenburg, Marc Jeuland, Uptal D Patel, John W Stanifer
BACKGROUND AND OBJECTIVES: Epidemics of CKD of uncertain etiology (CKDu) are emerging around the world. Highlighting common risk factors for CKD of uncertain etiology across various regions and populations may be important for health policy and public health responses. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We searched PubMed, Embase, Scopus and Web of Science databases to identify published studies on CKDu. The search was generated in January of 2015; no language or date limits were used...
March 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/26628792/endemic-chronic-kidney-disease-of-unknown-etiology-in-sri-lanka-correlation-of-pathology-with-clinical-stages
#16
S Wijetunge, N V I Ratnatunga, T D J Abeysekera, A W M Wazil, M Selvarajah
Chronic kidney disease of unknown etiology (CKDU) is endemic among the rural farming communities in several localities in and around the North Central region of Sri Lanka. This is an interstitial type renal disease and typically has an insidious onset and slow progression. This study was conducted to identify the pathological features in the different clinical stages of CKDU. This is a retrospective study of 251 renal biopsies identified to have a primary interstitial disease from regions endemic for CKDU. Pathological features were assessed and graded in relation to the clinical stage...
September 2015: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/26549834/neonicotinoid-concentrations-in-urine-from-chronic-kidney-disease-patients-in-the-north-central-region-of-sri-lanka
#17
Risako Kabata, Shanika Nanayakkara, Stmld Senevirathna, Kouji H Harada, Rohana Chandrajith, Toshiaki Hitomi, Tilak Abeysekera, Takumi Takasuga, Akio Koizumi
OBJECTIVES: Neonicotinoid insecticides have been widely used around the world since the 1990s. Reports have been made since the 1990s of rice paddy farmers in the North Central Region (NCR) of Sri Lanka suffering from chronic kidney disease with unknown etiology (CKDu). A preliminary evaluation of the exposure of local farmers in the NCR of Sri Lanka to neonicotinoids was performed. METHODS: We analyzed neonicotinoid and neonicotinoid metabolite concentrations in spot urine samples...
2016: Journal of Occupational Health
https://www.readbyqxmd.com/read/26462963/the-role-of-ions-heavy-metals-fluoride-and-agrochemicals-critical-evaluation-of-potential-aetiological-factors-of-chronic-kidney-disease-of-multifactorial-origin-ckdmfo-ckdu-and-recommendations-for-its-eradication
#18
REVIEW
Sunil J Wimalawansa
The pollution of water and food through human waste and anthropogenic activities, including industrial waste and agricultural runoff, is a mounting problem worldwide. Water pollution from microbes causes identifiable diarrhoeal illnesses. The consumption of water contaminated with heavy metals, fluoride, and other toxins causes insidious illnesses that lead to protracted, non-communicable diseases and death. Chronic kidney disease of unusual/uncertain/unknown aetiology is one such example, began to manifest in the mid-1960s in several dry-zonal agricultural societies in developing economies that are located around the equator...
June 2016: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/26452161/overlooked-risk-for-chronic-kidney-disease-after-leptospiral-infection-a-population-based-survey-and-epidemiological-cohort-evidence
#19
Huang-Yu Yang, Cheng-Chieh Hung, Su-Hsun Liu, Yi-Gen Guo, Yung-Chang Chen, Yi-Ching Ko, Chiung-Tseng Huang, Li-Fang Chou, Ya-Chung Tian, Ming-Yang Chang, Hsiang-Hao Hsu, Ming-Yen Lin, Shang-Jyh Hwang, Chih-Wei Yang
BACKGROUND: Leptospirosis is the most widespread zoonosis. Chronic human infection and asymptomatic colonization have been reported. However, renal involvement in those with leptospira chronic exposure remains undetermined. METHODS AND FINDINGS: In 2007, a multistage sampling survey for chronic kidney disease (CKD) was conducted in a southern county of Taiwan, an area with a high prevalence of dialysis. Additionally, an independent cohort of 88 participants from a leptospira-endemic town was followed for two years after a flooding in 2009...
2015: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/26282933/global-dimensions-of-chronic-kidney-disease-of-unknown-etiology-ckdu-a-modern-era-environmental-and-or-occupational-nephropathy
#20
Virginia M Weaver, Jeffrey J Fadrowski, Bernard G Jaar
No abstract text is available yet for this article.
August 19, 2015: BMC Nephrology
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