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Hani M Abujudeh, Adam Danielson, Michael A Bruno
OBJECTIVE: The purpose of this article is to review the tools and opportunities available for patient-centered care in radiology and to create a quality patient-centered care process map to organize them for radiology practices. CONCLUSION: This article provides a review of the many opportunities to increase and improve patient-centered care in radiology. A process map that organizes and highlights key elements of patient-centered care throughout the radiology care process is provided that can be implemented to enhance the patient experience of our services and improve the quality of care provided...
November 2016: AJR. American Journal of Roentgenology
Sitara Chauhan, Steven Danielson, Virginia Clements, Nathan J Edwards, Suzanne Ostrand-Rosenberg, Catherine Fenselau
In this report we use a proteomic strategy to identify glycoproteins on the surface of exosomes derived from myeloid-derived suppressor cells (MDSC), and then test if selected glycoproteins contribute to exosome-mediated chemotaxis and migration of MDSC. We report successful modification of a surface chemistry method for use with exosomes, and identify twenty-one surface N-glycoproteins on exosomes released by mouse mammary carcinoma-induced MDSC. These glycoprotein identities and functionalities are compared with ninty-three N-linked glycoproteins identified on the surface of the parental cells...
October 11, 2016: Journal of Proteome Research
Min-Seok Kim, Hong-Gook Lim, Woong Han Kim, Jeong Ryul Lee, Yong Jin Kim
BACKGROUND AND OBJECTIVES: The aim of the study is to evaluate the long-term results after a surgical repair of Ebstein's anomaly. SUBJECTS AND METHODS: Forty-eight patients with Ebstein's anomaly who underwent open heart surgery between 1982 and 2013 were included. Median age at operation was 5.6 years (1 day-42.1 years). Forty-five patients (93.7%) demonstrated tricuspid valve (TV) regurgitation of less than moderate degree. When the patients were divided according to Carpentier's classification, types A, B, C, and D were 11, 21, 12, and 4 patients, respectively...
September 2016: Korean Circulation Journal
Allison M Keeler, Ellen Sapp, Kathryn Chase, Emily Sottosanti, Eric Danielson, Edith Pfister, Lorelei Stoica, Marian DiFiglia, Neil Aronin, Miguel Sena-Esteves
BACKGROUND: The genetic mutation in Huntington's disease (HD) is a CAG repeat expansion in the coding region of the huntingtin (Htt) gene. RNAi strategies have proven effective in substantially down-regulating Htt mRNA in the striatum through delivery of siRNAs or viral vectors based on whole tissue assays, but the extent of htt mRNA lowering in individual neurons is unknown. OBJECTIVE: Here we characterize the effect of an AAV9-GFP-miRHtt vector on Htt mRNA levels in striatal neurons of Q140/Q140 knock-in mice...
October 1, 2016: Journal of Huntington's Disease
Stephanie S Caston, Jennifer A Schleining, Jared A Danielson, Kevin D Kersh, Eric L Reinertson
OBJECTIVE: To determine if instruction using simulated small intestine (SSI) is as effective as using cadaveric small intestine to teach the Gambee suture pattern to second year veterinary students. STUDY DESIGN: Prospective, randomized, blinded study. SAMPLE POPULATION: Second year veterinary students (n=59). METHODS: Students were randomly assigned to groups using SSI or equine cadaver small intestine (CSI) to learn the Gambee suture pattern...
September 29, 2016: Veterinary Surgery: VS
Chunxing Yang, Eric W Danielson, Tao Qiao, Jake Metterville, Robert H Brown, John E Landers, Zuoshang Xu
Mutations in the profilin 1 (PFN1) gene cause amyotrophic lateral sclerosis (ALS), a neurodegenerative disease caused by the loss of motor neurons leading to paralysis and eventually death. PFN1 is a small actin-binding protein that promotes formin-based actin polymerization and regulates numerous cellular functions, but how the mutations in PFN1 cause ALS is unclear. To investigate this problem, we have generated transgenic mice expressing either the ALS-associated mutant (C71G) or wild-type protein. Here, we report that mice expressing the mutant, but not the wild-type, protein had relentless progression of motor neuron loss with concomitant progressive muscle weakness ending in paralysis and death...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
Christina Gross, Xiaodi Yao, Tobias Engel, Durgesh Tiwari, Lei Xing, Shane Rowley, Scott W Danielson, Kristen T Thomas, Eva M Jimenez-Mateos, Lindsay M Schroeder, Raymund Y K Pun, Steve C Danzer, David C Henshall, Gary J Bassell
Seizures are bursts of excessive synchronized neuronal activity, suggesting that mechanisms controlling brain excitability are compromised. The voltage-gated potassium channel Kv4.2, a major mediator of hyperpolarizing A-type currents in the brain, is a crucial regulator of neuronal excitability. Kv4.2 expression levels are reduced following seizures and in epilepsy, but the underlying mechanisms remain unclear. Here, we report that Kv4.2 mRNA is recruited to the RNA-induced silencing complex shortly after status epilepticus in mice and after kainic acid treatment of hippocampal neurons, coincident with reduction of Kv4...
September 27, 2016: Cell Reports
S Baker, A Duimering, K Paulson, B J Debenham, S Ghosh, D L Ma, F Huang, K P M Chu, D M Severin, J O Amanie, T Nijjar, S I Patel, B Danielson, E M Wiebe, B LeGuerrier, A M Fairchild
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Lisa J Woodard, Skye McKennon, Jennifer Danielson, Judy Knuth, Peggy Odegard
Objective. To develop and assess the impact of an elective course aimed at improving student knowledge of and confidence in delivering a group diabetes prevention program. Design. Two colleges of pharmacy collaborated to develop a 2-credit elective course using didactic and active-learning strategies to prepare students to serve as lifestyle coaches offering a proven group diabetes prevention program. Assessment. Students' confidence in their ability to deliver a group diabetes prevention program increased as a result of the class...
August 25, 2016: American Journal of Pharmaceutical Education
Linda Høgsnes, Karl-Gustaf Norbergh, Ella Danielson, Christina Melin-Johansson
BACKGROUND: Previous research describes spouses and adult children of people with dementia as a homogeneous group using one term: family caregivers. Recent research shows that the needs and experiences of spouses and adult children differ, therefore they cannot be studied as a homogeneous group. AIMS: The aim of the study was to describe the shift in existential life situations of adult children of a parent with dementia relocated to nursing homes. DESIGN: This is a qualitative study with an interpretive approach...
2016: Open Nursing Journal
Cristen N Litz, David J Ciesla, Paul D Danielson, Nicole M Chandler
PURPOSE: The purpose of this study was to examine the outcomes of non-accidental trauma (NAT) patients compared to other trauma (OT) patients across the state of Florida. In addition, NAT and OT patients with a mechanism of injury of assault were further analyzed. METHODS: A statewide database was reviewed from January 2010 to December 2014 for patients aged 0-18years who presented following trauma. Patients were sorted by admitting diagnosis into two groups: rule out NAT and all other diagnoses...
September 2, 2016: Journal of Pediatric Surgery
Kaitlin Bountress, Zachary W Adams, Amanda K Gilmore, Ananda B Amstadter, Suzanne Thomas, Carla K Danielson
OBJECTIVE: Young adult alcohol misuse is associated with numerous long-term adverse outcomes. Given the link between impulsivity and alcohol use, we examined whether three impulsivity-related traits differentially predicted number of drinks per drinking day (DDD). We also examined whether these effects varied for those with different trauma histories. METHOD: The current study (n=254) examined motor, non-planning, and attentional impulsivity as predictors of DDD...
August 26, 2016: Addictive Behaviors
Sebastian Poloczek, Lucy A Henry, Henrik Danielson, Gerhard Büttner, Claudia Mähler, David J Messer, Kirsten Schuchardt, Mariët J van der Molen
BACKGROUND: There is a long-held view that verbal short-term memory problems of individuals with intellectual disabilities (ID) might be due to a deficit in verbal rehearsal. However, the evidence is inconclusive and word length effects as indicator of rehearsal have been criticised. AIM & METHOD: The aim of this multi-site European study was to investigate verbal rehearsal in adolescents with mild ID (n=90) and a comparison group of typically developing children matched individually for mental age (MA, n=90)...
November 2016: Research in Developmental Disabilities
Simion Kreimer, Mikhail E Belov, William F Danielson, Lev I Levitsky, Mikhail V Gorshkov, Barry L Karger, Alexander R Ivanov
Conventional TopN data-dependent acquisition (DDA) LC-MS/MS analysis identifies only a limited fraction of all detectable precursors because the ion-sampling rate of contemporary mass spectrometers is insufficient to target each precursor in a complex sample. TopN DDA preferentially targets high-abundance precursors with limited sampling of low-abundance precursors and repeated analyses only marginally improve sample coverage due to redundant precursor sampling. In this work, advanced precursor ion selection algorithms were developed and applied in the bottom-up analysis of HeLa cell lysate to overcome the above deficiencies...
October 7, 2016: Journal of Proteome Research
Jean-Paul Renaud, Chun-Wa Chung, U Helena Danielson, Ursula Egner, Michael Hennig, Roderick E Hubbard, Herbert Nar
Over the past 25 years, biophysical technologies such as X-ray crystallography, nuclear magnetic resonance spectroscopy, surface plasmon resonance spectroscopy and isothermal titration calorimetry have become key components of drug discovery platforms in many pharmaceutical companies and academic laboratories. There have been great improvements in the speed, sensitivity and range of possible measurements, providing high-resolution mechanistic, kinetic, thermodynamic and structural information on compound-target interactions...
October 2016: Nature Reviews. Drug Discovery
Dorothy W U Overington, Kate J Jeffery
Danielson et al. (2016) use calcium imaging in mice performing a treadmill task to reveal differences in space-coding dynamics between deep and superficial sublayers of hippocampal CA1, suggesting how the hippocampus might encode both stable and dynamic information simultaneously.
August 3, 2016: Neuron
Merrel T Holley, Neerajha Nagarajan, Christian Danielson, Pinar Zorlutuna, Kidong Park
Biorobots that harness the power generated by living muscle cells have recently gained interest as an alternative to traditional mechanical robots. However, robust and reliable operation of these biorobots still remains a challenge. Toward this end, we developed a self-stabilizing swimming biorobot that can maintain its submersion depth, pitch, and roll without external intervention. The biorobot developed in this study utilized a fin-based propulsion mechanism. It consisted of a base made from two composite PDMS materials and a thin PDMS cantilever seeded with a confluent layer of heart muscle cells...
September 21, 2016: Lab on a Chip
Carly M Danielson, Tara M Emmers-Sommer
Bullying is on the rise, and bullied targets often face consequences when they do not effectively manage their victimization. This study investigates bullied bloggers' use and evaluations of coping strategies and support sources. Informed by Lazarus and Folkman's (1984) appraisal theory, Tenenbaum, Varjas, Meyers, and Parris's (2011) model of bullied students' coping, and social support literature, bullied students' narratives (N = 100) from five bullying blogs (Pacer's, I'm Getting Bullied, ReachOut, BullyVille, No Place 4 Hate) are examined...
July 27, 2016: Health Communication
Nathan B Danielson, Jeffrey D Zaremba, Patrick Kaifosh, John Bowler, Max Ladow, Attila Losonczy
The mammalian hippocampus is critical for spatial information processing and episodic memory. Its primary output cells, CA1 pyramidal cells (CA1 PCs), vary in genetics, morphology, connectivity, and electrophysiological properties. It is therefore possible that distinct CA1 PC subpopulations encode different features of the environment and differentially contribute to learning. To test this hypothesis, we optically monitored activity in deep and superficial CA1 PCs segregated along the radial axis of the mouse hippocampus and assessed the relationship between sublayer dynamics and learning...
August 3, 2016: Neuron
Jane A Cauley, Kamil E Barbour, Stephanie L Harrison, Yona K Cloonan, Michelle E Danielson, Kristine E Ensrud, Howard A Fink, Eric S Orwoll, Robert Boudreau
Cytokines play major roles in regulating bone remodeling but their relationship to incident fractures in older men is uncertain. We tested the hypothesis that men with higher concentrations of pro-inflammatory markers have a higher risk of fracture. We used a case-cohort design and measured inflammatory markers in a random sample of 961 men and in men with incident fractures including 120 clinical vertebral, 117 hip and 577 non-spine fractures; average follow up, 6.13 years (7.88 years for vertebral fractures)...
July 2, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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