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https://www.readbyqxmd.com/read/29468737/school-based-study-found-that-physical-activity-and-aerobic-fitness-predicted-increases-in-total-body-fat-and-abdominal-fat-at-a-mean-age-of-9-8-years
#1
Anton Danielson, Ola Thorsson, Magnus K Karlsson, Per Wollmer, Lars B Andersen, Magnus Dencker
AIM: We assessed if baseline measurements of physical activity, aerobic fitness, body fat and abdominal fat were predictors of changes in body fat measurements over a two-year period. METHODS: The study comprised of 204 children aged 9.8 ±0.6 years with a normal body mass distribution, who recruited from four schools in middle-class areas of Malmö, Sweden, from 2001-2004. Peak oxygen uptake and physical activity were measured at baseline. Body fat was measured by dual-energy x-ray absorptiometry at baseline and two years later...
February 22, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29466001/introduction-of-intrinsic-kinetics-of-protein-ligand-interactions-and-their-implications-for-drug-design
#2
Vaida Linkuvienė, Vladimir O Talibov, U Helena Danielson, Daumantas Matulis
Structure-kinetic relationship analyses and identification of dominating interactions for optimisation of lead compounds should ideally be based on intrinsic rate constants instead of the more easily accessible observed kinetic constants, which account also for binding-linked reactions. The intrinsic rate constants for sulfonamide inhibitors and pharmacologically relevant isoforms of carbonic anhydrase were determined by a novel surface plasmon resonance (SPR) biosensor-based approach, using chemodynamic analysis of binding-linked pH-dependent effects...
February 21, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29401429/helical-propensity-affects-the-conformational-properties-of-the-denatured-state-of-cytochrome-c
#3
Travis A Danielson, Bruce E Bowler
Changing the helical propensity of a polypeptide sequence might be expected to affect the conformational properties of the denatured state of a protein. To test this hypothesis, alanines at positions 83 and 87 near the center of helix 3 of cytochrome c' from Rhodopseudomonas palustris were mutated to serine to decrease the stability of this helix. A set of 13 single histidine variants in the A83S/A87S background were prepared to permit assessment of the conformational properties of the denatured state using histidine-loop formation in 3 M guanidine hydrochloride...
January 23, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29388133/extracellular-rna-isolation-from-cell-culture-supernatant
#4
Sawen Bakr, Bridget Simonson, Kirsty M Danielson, Saumya Das
Extracellular RNAs are emerging as novel biomarkers and mediators of intercellular communication. Various methods to isolate RNA from biofluids and cell culture supernatants have been previously used by investigators. Here, we describe several standardized protocols for the isolation of RNAs from cell culture supernatants that utilize commercially available kits and reagents.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29382370/supraclavicular-subclavian-access-for-sapien-transcatheter-aortic-valve-replacement-a-novel-approach
#5
Thom G Dahle, Nathaniel J Castro, Brian M Stegman, Jacob R Dutcher, John M Teskey, Wade T Schmidt, Daren S Danielson, Sara J Dezell, Virginia B Daniels, Daniel J Tiede
BACKGROUND: Within the trans-subclavian approach, procedural techniques can vary widely, and reported access generally refers to an infraclavicular axillary approach. We describe and report the use of a novel supraclavicular true subclavian approach for transcatheter aortic valve replacement (TAVR) exclusively for implantation of Sapien 3 valves. CASE PRESENTATION: We report our first five consecutive patients undergoing TAVR with a Sapien 3 valve using a standardized subclavian approach at a single center...
January 30, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29363986/prevalence-of-parent-reported-adhd-diagnosis-and-associated-treatment-among-u-s-children-and-adolescents-2016
#6
Melissa L Danielson, Rebecca H Bitsko, Reem M Ghandour, Joseph R Holbrook, Michael D Kogan, Stephen J Blumberg
The purpose of this study is to estimate the national prevalence of parent-reported attention deficit/hyperactivity disorder (ADHD) diagnosis and treatment among U.S. children 2-17 years of age using the 2016 National Survey of Children's Health (NSCH). The NSCH is a nationally representative, cross-sectional survey of parents regarding their children's health that underwent a redesign before the 2016 data collection. It included indicators of lifetime receipt of an ADHD diagnosis by a health care provider, whether the child currently had ADHD, and receipt of medication and behavioral treatment for ADHD...
January 24, 2018: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29363212/photoredox-based-actuation-of-an-artificial-molecular-muscle
#7
Kevin P Liles, Angelique F Greene, Mary K Danielson, Nathan D Colley, Andrew Wellen, Jeremy M Fisher, Jonathan C Barnes
The use of light to actuate materials is advantageous because it represents a cost-effective and operationally straightforward way to introduce energy into a stimuli-responsive system. Common strategies for photoinduced actuation of materials typically rely on light irradiation to isomerize azobenzene or spiropyran derivatives, or to induce unidirectional rotation of molecular motors incorporated into a 3D polymer network. Although interest in photoredox catalysis has risen exponentially in the past decade, there are far fewer examples where photoinduced electron transfer (PET) processes are employed to actuate materials...
January 24, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29346342/attention-deficit-hyperactivity-disorder-medication-prescription-claims-among-privately-insured-women-aged-15-44-years-united-states-2003-2015
#8
Kayla N Anderson, Elizabeth C Ailes, Melissa Danielson, Jennifer N Lind, Sherry L Farr, Cheryl S Broussard, Sarah C Tinker
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that affects individuals across the lifespan. ADHD medication use among pregnant women is increasing (1), but consensus about the safety of ADHD medication use during pregnancy is lacking. Given that nearly half of U.S. pregnancies are unintended (2), and early pregnancy is a critical period for fetal development, examining trends in ADHD medication prescriptions among reproductive-aged women is important to quantify the population at risk for potential exposure...
January 19, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29306866/mechanical-stress-potentiates-the-differentiation-of-periodontal-ligament-stem-cells-into-keratocytes
#9
Jialin Chen, Wei Zhang, Ludvig J Backman, Peyman Kelk, Patrik Danielson
AIMS: To explore the role of corneal-shaped static mechanical strain on the differentiation of human periodontal ligament stem cells (PDLSCs) into keratocytes and the possible synergistic effects of mechanics and inducing medium. METHODS: PDLSCs were exposed to 3% static dome-shaped mechanical strain in a Flexcell Tension System for 3 days and 7 days. Keratocyte phenotype was determined by gene expression of keratocyte markers. Keratocyte differentiation (inducing) medium was introduced in the Flexcell system, either continuously or intermittently combined with mechanical stimulation...
January 6, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29306566/bispecific-chimeric-antigen-receptors-targeting-the-cd4-binding-site-and-high-mannose-glycans-of-gp120-optimized-for-anti-human-immunodeficiency-virus-potency-and-breadth-with-minimal-immunogenicity
#10
Mustafa H Ghanem, Sara Bolivar-Wagers, Barna Dey, Agnes Hajduczki, Diego A Vargas-Inchaustegui, David T Danielson, Virgilio Bundoc, Li Liu, Edward A Berger
BACKGROUND AIMS: Chimeric antigen receptors (CARs) offer great potential toward a functional cure of human immunodeficiency virus (HIV) infection. To achieve the necessary long-term virus suppression, we believe that CARs must be designed for optimal potency and anti-HIV specificity, and also for minimal probability of virus escape and CAR immunogenicity. CARs containing antibody-based motifs are problematic in the latter regard due to epitope mutation and anti-idiotypic immune responses against the variable regions...
January 3, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29247734/human-chitotriosidase-does-not-catabolize-hyaluronan
#11
Ben Danielson, Che-Hong Chen, Gernot Kaber, Daria Mochly-Rosen, Kevin Grimes, Robert Stern, Paul L Bollyky
Humans express an enzyme that degrades chitin, called chitotriosidase, despite the fact that we do not produce chitin. One possible explanation for this is that chitinase also degrades hyaluronan, a polysaccharide that is abundant in human tissues and shares structural attributes in common with chitinase. The objective of this study was to determine whether human chitotriosidase is capable of hydrolyzing hyaluronan. Hyaluronan of various sizes under a range of pH conditions displayed no degradation when incubated with various chitinases over a period of 5 days, while commercial hyaluronidase readily digested the hyaluronan...
December 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29230944/improved-insulin-sensitivity-appears-to-remain-for-a-mean-of-four-years-following-islet-cell-transplant-for-type-1-diabetes
#12
Brett Rydzon, Rebecca S Monson, Jose Oberholzer, Krista A Varady, Melena D Bellin, Kirstie K Danielson
BACKGROUND: Impaired insulin sensitivity (IS) predicts complications and mortality in type 1 diabetes (T1D). IS improves shortly after islet cell transplant for type 1 diabetes, yet long-term changes in IS, and associated factors such as patient characteristics, transplant factors, clinical management, and IS-related biomarkers are unknown. METHODS: Up to nine years (mean four) of longitudinal data were available on 22 adults (18 female) with T1D who received 1-3 transplants in Phase 1/2 or 3 clinical trials (2004-2014)...
December 12, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29230314/testing-the-effectiveness-of-a-transdiagnostic-treatment-approach-in-reducing-violence-and-alcohol-abuse-among-families-in-zambia-study-protocol-of-the-violence-and-alcohol-treatment-vatu-trial
#13
J C Kane, S Skavenski Van Wyk, S M Murray, P Bolton, F Melendez, C K Danielson, P Chimponda, S Munthali, L K Murray
Background: Violence against women and girls (VAWG) is an urgent global health problem. Root causes for VAWG include the individual- and family-level factors of alcohol abuse, mental health problems, violence exposure, and related adverse experiences. Few studies in low- and middle-income countries (LMIC) have assessed the effectiveness of psychological interventions for reducing VAWG. This randomized controlled trial, part of the What Works to Prevent Violence Against Women and Girls consortium, examines the effectiveness of a common elements treatment approach (CETA) for reducing VAWG and comorbid alcohol abuse among families in Zambia...
2017: Global Mental Health
https://www.readbyqxmd.com/read/29228983/characterization-of-interactions-between-hepatitis-c-virus-ns5b-polymerase-annexin-a2-and-rna-effects-on-ns5b-catalysis-and-allosteric-inhibition
#14
Sara M Ø Solbak, Eldar Abdurakhmanov, Anni Vedeler, U Helena Danielson
BACKGROUND: Direct acting antivirals (DAAs) provide efficient hepatitis C virus (HCV) therapy and clearance for a majority of patients, but are not available or effective for all patients. They risk developing HCV-induced hepatocellular carcinoma (HCC), for which the mechanism remains obscure and therapy is missing. Annexin A2 (AnxA2) has been reported to co-precipitate with the non-structural (NS) HCV proteins NS5B and NS3/NS4A, indicating a role in HCC tumorigenesis and effect on DAA therapy...
December 11, 2017: Virology Journal
https://www.readbyqxmd.com/read/29198897/the-idle-central-venous-catheter-in-the-nicu-when-should-it-be-removed
#15
Cristen N Litz, Jordan G Tropf, Paul D Danielson, Nicole M Chandler
PURPOSE: There is debate regarding the optimal timing of central line removal in the neonatal intensive care unit (NICU). The purpose was to evaluate outcomes of idle peripherally inserted central catheters (PICCs) and tunneled central venous catheters (TCVCs) and determine the incidence of line-related infections and replacements. METHODS: Patients in the NICU with T-CVCs placed between 11/2008 and 8/2015 (n=134) or PICCs placed between 7/2013 and 10/2015 (n=467) were included...
November 9, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29187099/in-memoriam-gordon-k-danielson-1931-2017
#16
Joseph A Dearani
No abstract text is available yet for this article.
November 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29148740/effect-of-an-imposed-contact-on-secondary-structure-in-the-denatured-state-of-yeast-iso-1-cytochome-c
#17
Travis A Danielson, Jessica M Stine, Tanveer A Dar, Klara Briknarova, Bruce E Bowler
There is considerable evidence that long-range interactions stabilize residual protein structure under denaturing conditions. However, evaluation of the effect of a specific contact on structure in the denatured state has been difficult. Iso-1-cytochrome c variants with a Lys54-->His mutation form a particularly stable His-heme loop in the denatured state, suggestive of loop-induced residual structure. We have used multidimensional NMR methods to assign (1)H and (15)N backbone amide and (13)C backbone and side chain chemical shifts in the denatured state of iso-1-cytochrome c carrying the Lys54-->His mutation in 3 and 6 M guanidine hydrochloride and at both pH 6...
November 17, 2017: Biochemistry
https://www.readbyqxmd.com/read/29137712/hydrophilic-interaction-liquid-chromatography-of-hydroxy-aromatic-carboxylic-acid-positional-isomers
#18
Ashley E Richardson, Neil D Danielson
Hydrophilic interaction liquid chromatography (HILIC) has become increasingly popular as an alternative to reversed phase LC due to its ease of separating complex polar compound mixtures and the compatibility of the mobile phase with mass spectrometry (MS). Using a plain silica column (150  mm × 4.6  mm), we have shown a mixture containing three hydroxybenzoic acid isomers plus syringic and vanillic acid and three hydroxycinnamic acid isomers plus ferulic and sinapic acid can be separated using a mobile phase comprised of 90% acetonitrile (MeCN) and 10% 20 mM ammonium acetate at pH 6 in under 45 min...
December 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29136471/below-room-temperature-c-h-bond-breaking-on-an-inexpensive-metal-oxide-methanol-to-formaldehyde-on-ceo2-111
#19
Jonathan E Sutton, Thomas Danielson, Ariana Beste, Aditya Savara
Upgrading of primary alcohols by C-H bond breaking currently requires temperatures of >200 °C. In this work, new understanding from simulation of a temperature-programmed reaction study with methanol over a CeO2(111) surface shows C-H bond breaking and the subsequent desorption of formaldehyde, even below room temperature. This is of particular interest because CeO2 is a naturally abundant and inexpensive metal oxide. We combine density functional theory and kinetic Monte Carlo methods to show that the low-temperature C-H bond breaking occurs via disproportionation of adjacent methoxy species...
November 15, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29132817/a-national-description-of-treatment-among-united-states-children-and-adolescents-with-attention-deficit-hyperactivity-disorder
#20
Melissa L Danielson, Susanna N Visser, Andrea Chronis-Tuscano, George J DuPaul
OBJECTIVE: To characterize lifetime and current rates of attention-deficit/hyperactivity disorder (ADHD) treatments among US children and adolescents with current ADHD and describe the association of these treatments with demographic and clinical factors. STUDY DESIGN: Data are from the 2014 National Survey of the Diagnosis and Treatment of ADHD and Tourette Syndrome, a follow-back survey of parents from the 2011-2012 National Survey of Children's Health. Weighted analyses focused on receipt of ADHD treatment among children aged 4-17 years with current ADHD (n = 2495) by 4 treatment types: medication, school supports, psychosocial interventions, and alternative treatments...
November 10, 2017: Journal of Pediatrics
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