keyword
MENU ▼
Read by QxMD icon Read
search

Danielson

keyword
https://www.readbyqxmd.com/read/28432815/immunoassays-for-the-quantification-of-alk-and-phosphorylated-alk-support-the-evaluation-of-on-target-alk-inhibitors-in-neuroblastoma
#1
Elizabeth R Tucker, Jennifer R Tall, Laura S Danielson, Sharon Gowan, Yann Jamin, Simon P Robinson, Udai Banerji, Louis Chesler
Targeted inhibition of Anaplastic Lymphoma Kinase (ALK) is a successful approach for the treatment of many ALK-aberrant malignancies, however the presence of resistant mutations necessitates both the development of more potent compounds and pharmacodynamic methods with which to determine their efficacy. We describe immunoassays designed to quantitate phosphorylation of ALK, and their use in preclinical models of neuroblastoma, a pediatric malignancy in which gain-of-function ALK mutations predict a poor overall outcome to conventional treatment...
April 22, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28425120/unravelling-swedish-informal-caregivers-generalised-resistance-deficits
#2
Mia M T Wennerberg, Monica Eriksson, Solveig M Lundgren, Ella Danielson
In salutogenic theory, individual/contextual, immaterial/material characteristics enabling movements towards health are labelled Specific and Generalised Resistance Resources, SRRs/GRRs, and characteristics counteracting such movements Specific and Generalised Resistance Deficits, SRDs/GRDs. The aim of this paper was to present SRDs and GRDs described by caregivers as stemming from themselves and their care recipient. Guided by salutogenic theory, an explorative design was used to collect data through interviews with 32 Swedish informal caregivers...
April 20, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28408075/effect-of-hospital-type-on-the-treatment-of-acute-appendicitis-in-teenagers
#3
Cristen N Litz, David J Ciesla, Paul D Danielson, Nicole M Chandler
BACKGROUND: Teenagers receive appendicitis care at both adult and pediatric facilities. The purpose of this study was to evaluate outcomes following treatment of acute appendicitis in teenagers based on the type of hospital facility. METHODS: Patients aged 13-17years with acute appendicitis who were discharged from acute care hospitals from 2009 to 2014 were identified using a statewide discharge dataset. Hospitals were classified as pediatric or adult and outcomes were compared...
April 5, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28401057/intestinal-hypoganglionosis-leading-to-intestinal-failure-and-the-compassionate-use-of-omegaven%C3%A2
#4
Racha Khalaf, Sara Karjoo, Paul Danielson, Michael Wilsey, Fauzia Shakeel
Intestinal hypoganglionosis is a rare innervation disorder that provides numerous nutritional, medical and surgical challenges. In this case report, we present a case of a newborn with intestinal hypoganglionosis leading to intestinal failure and intestinal failure-associated liver disease who responded to Omegaven™, a fat emulsion comprised of omega-3 fatty acids. Omegaven™ has been shown to be beneficial in the management of cholestatic liver injury. Clinical success with Omegaven™ was seen in this patient with a clear decrease in aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and complete resolution of cholestasis with a direct bilirubin of zero within two weeks of initiation of Omegaven™...
March 2017: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/28392047/monitoring-drug-serum-protein-interactions-for-early-adme-prediction-through-surface-plasmon-resonance-technology
#5
Edoardo Fabini, U Helena Danielson
Many molecules fail to reach the market due to poor pharmacokinetic (PK) properties, rendering the potential drug virtually unavailable for the primary target despite efficient administration to the body. PK properties of endogenous and exogenous compounds in mammals are dependent, among other factors, on their ability to interact with serum proteins. The extent of binding can greatly influence their ADME (adsorption, distribution, metabolism and execration) profile. Reliable and cost-effective bioavailability studies, early in the drug discovery process, can lead to an improvement of the success rate for compounds entering clinical trials...
March 28, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28381887/best-practices-in-establishing-and-sustaining-consortia-in-pharmacy-education
#6
Jennifer Danielson, Ana Hincapie, Gina Baugh, Luke Rice, Erin Sy, Jonathan Penm, Christian Albano
Objective. To describe best practices, necessary resources, and success or lessons learned from established consortia in pharmacy education. Methods. Using semi-structured interviews and qualitative analysis, interviews with members of established consortia in pharmacy education were conducted until saturation was reached. Themes were analyzed and meaningful descriptions of consortia characteristics were developed using systematic text condensation. Results. Thirteen interviews were conducted. The primary purpose for forming a consortium was identified as threefold: share ideas/best practices; facilitate collaboration; and perform shared problem-solving...
March 25, 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28377023/percutaneous-ultrasound-guided-vs-intraoperative-rectus-sheath-block-for-pediatric-umbilical-hernia-repair-a-randomized-clinical-trial
#7
Cristen N Litz, Sandra M Farach, Allison M Fernandez, Richard Elliott, Jenny Dolan, Nikhil Patel, Lillian Zamora, Paul M Colombani, Nebbie E Walford, Ernest K Amankwah, Christopher W Snyder, Paul D Danielson, Nicole M Chandler
BACKGROUND: Regional anesthesia is commonly used in children. Our hypothesis was that percutaneous ultrasound-guided (PERC) rectus sheath blocks would result in lower postoperative pain scores compared to intraoperative (IO) rectus sheath blocks following umbilical hernia repair. METHODS: A single-institution randomized blinded trial was conducted in pediatric patients undergoing elective umbilical hernia repair. The primary outcome was mean postoperative Wong-Baker pain score...
March 16, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28370228/pharmacologic-treatment-of-cannabinoid-hyperemesis-syndrome-a-systematic-review
#8
John R Richards, Brent K Gordon, Aaron R Danielson, Aimee K Moulin
OBJECTIVE: Cannabinoid hyperemesis syndrome (CHS) has become more prevalent with increasing cannabis use. CHS is often resistant to standard antiemetics. The objective of this study is to review the current evidence for pharmacologic treatment of CHS. METHODS: MEDLINE, PsycINFO, DARE, OpenGrey, Google Scholar, and the Cochrane Library were searched from inception to February 2017. Articles were selected and reviewed independently. Evidence was graded using Oxford CEBM guidelines...
March 31, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28369733/feeding-in-fear-how-adult-male-western-chimpanzees-pan-troglodytes-verus-adjust-to-predation-and-savanna-habitat-pressures
#9
Stacy Lindshield, Brent J Danielson, Jessica M Rothman, Jill D Pruetz
OBJECTIVES: We evaluated risk-sensitive foraging in adult male western chimpanzees (Pan troglodytes verus) occupying a savanna environment at Fongoli, Senegal. The aim of this study was to determine how the risks of predation and heat stress influenced their behavior while feeding on a key food, fruit of the baobab tree (Adansonia digitata). MATERIALS AND METHODS: Proximity of fruiting baobab trees to anthropogenic landmarks were compared to food intake, feeding rate, and behavioral indicators of fear in adult males (N = 11) at Fongoli...
March 28, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28356300/reassessing-phase-ii-heart-failure-clinical-trials-consensus-recommendations
#10
Javed Butler, Carine E Hamo, James E Udelson, Christopher O'Connor, Hani N Sabbah, Marco Metra, Sanjiv J Shah, Dalane W Kitzman, John R Teerlink, Harold S Bernstein, Gabriel Brooks, Christophe Depre, Mary M DeSouza, Wilfried Dinh, Mark Donovan, Regina Frische-Danielson, Robert J Frost, Dahlia Garza, Udo-Michael Gohring, Jennifer Hellawell, Judith Hsia, Shiro Ishihara, Patricia Kay-Mugford, Joerg Koglin, Marc Kozinn, Christopher J Larson, Martha Mayo, Li-Ming Gan, Pierrre Mugnier, Sekayi Mushonga, Lothar Roessig, Cesare Russo, Afshin Salsali, Carol Satler, Victor Shi, Barry Ticho, Michael van der Laan, Clyde Yancy, Norman Stockbridge, Mihai Gheorghiade
The increasing burden and the continued suboptimal outcomes for patients with heart failure underlines the importance of continued research to develop novel therapeutics for this disorder. This can only be accomplished with successful translation of basic science discoveries into direct human application through effective clinical trial design and execution that results in a substantially improved clinical course and outcomes. In this respect, phase II clinical trials play a pivotal role in determining which of the multitude of potential basic science discoveries should move to the large and expansive registration trials in humans...
April 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28332906/undergraduate-rigor-scores-do-they-predict-achievement-in-veterinary-school
#11
Rebecca G Burzette, Jared A Danielson, Tsui-Feng Wu, Amanda J Fales-Williams, Kathryn H Kuehl
The relations between potential indicators of undergraduate rigor and subsequent achievement in professional school are not clear; some studies have shown that greater undergraduate selectivity is associated with greater achievement in medical science programs, while others have not. We sought to determine the extent to which indicators of undergraduate rigor were associated with achievement in veterinary school. Participants were graduates from three cohorts. The predictors were undergraduate GPA (UGPA), plus five rigor scores-degree or number of undergraduate credits, number of honors courses, number of withdrawals from or repeats of prerequisite science courses, number of part-time semesters, and ratio of community college credits to total college credits...
March 23, 2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/28328236/treated-prevalence-of-attention-deficit-hyperactivity-disorder-increased-from-2009-to-2015-among-school-aged-children-and-adolescents-in-the-united-states
#12
Kwame A Nyarko, Scott D Grosse, Melissa L Danielson, Joseph R Holbrook, Susanna N Visser, Stuart K Shapira
OBJECTIVES: The purpose of this brief is to describe changes in the treated prevalence of medically managed attention-deficit/hyperactivity disorder (ADHD) among insured school-aged children and adolescents in the United States from 2009 to 2015. We examine the differences between those with employer-sponsored insurance (ESI) and with Medicaid insurance. METHODS: We utilized two large longitudinal administrative datasets containing medical and drug claims data on individuals with ESI and Medicaid insurance from Truven Health MarketScan(®) Administrative Claims Databases...
March 22, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28324031/sex-steroid-hormones-and-fracture-in-a-multi-ethnic-cohort-of-women-the-women-s-health-initiative-study-whi
#13
Jane A Cauley, Michelle E Danielson, Guru Rajesh Jammy, Doug C Bauer, Rebecca Jackson, Jean Wactawski-Wende, Rowan T Chlebowski, Kristine E Ensrud, Robert Boudreau
CONTEXT: We hypothesize that endogenous sex steroids are associated with fracture risk independent of race/ethnicity. DESIGN AND SETTING: We performed a nested case-control study within the prospective Women's Health Initiative Observational Study (WHI-OS). Incident non-spine fractures were identified in 381 Black, 192 Hispanic, 112 Asian, and 46 Native American women over an average of 8.6 years. A random sample of 400 White women who experienced an incident fracture was chosen...
January 25, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28301610/the-effects-of-substance-p-and-acetylcholine-on-human-tenocyte-proliferation-converge-mechanistically-via-tgf-%C3%AE-1
#14
Gloria Fong, Ludvig J Backman, Håkan Alfredson, Alex Scott, Patrik Danielson
Previous in vitro studies on human tendon cells (tenocytes) have demonstrated that the exogenous administration of substance P (SP) and acetylcholine (ACh) independently result in tenocyte proliferation, which is a prominent feature of tendinosis. Interestingly, the possible link between SP and ACh has not yet been explored in human tenocytes. Recent studies in other cell types demonstrate that both SP and ACh independently upregulate TGF-β1 expression via their respective receptors, the neurokinin 1 receptor (NK-1R) and muscarinic ACh receptors (mAChRs)...
2017: PloS One
https://www.readbyqxmd.com/read/28276172/ascorbic-acid-promotes-the-stemness-of-corneal-epithelial-stem-progenitor-cells-and-accelerates-epithelial-wound-healing-in-the-cornea
#15
Jialin Chen, Jie Lan, Dongle Liu, Ludvig J Backman, Wei Zhang, Qingjun Zhou, Patrik Danielson
High concentration of ascorbic acid (vitamin C) has been found in corneal epithelium of various species. However, the specific functions and mechanisms of ascorbic acid in the repair of corneal epithelium are not clear. In this study, it was found that ascorbic acid accelerates corneal epithelial wound healing in vivo in mouse. In addition, ascorbic acid enhanced the stemness of cultured mouse corneal epithelial stem/progenitor cells (TKE2) in vitro, as shown by elevated clone formation ability and increased expression of stemness markers (especially p63 and SOX2)...
March 9, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28273530/kinetic-sorption-of-contaminants-of-emerging-concern-by-a-palygorskite-montmorillonite-filter-medium
#16
Tedros M Berhane, Jonathan Levy, Mark P S Krekeler, Neil D Danielson
Kinetic sorption of bisphenol A (BPA), carbamazepine (CMZ) and ciprofloxacin (CIP) by three palygorskite-montmorillonite (Pal-Mt) granule sizes was studied. For BPA, CMZ and CIP, apparent sorption equilibrium was reached within about 3, 5 and 16 h, respectively. The highest and the lowest sorption capacities were by the small and the large granule sizes, respectively. Experimental results were compared to various sorption kinetics models to gain insights regarding the sorption processes and achieve a predictive capacity...
February 17, 2017: Chemosphere
https://www.readbyqxmd.com/read/28258718/micellar-liquid-chromatography-of-terephthalic-acid-impurities
#17
Ashley E Richardson, Shakeela D McPherson, Jennifer M Fasciano, Richard E Pauls, Neil D Danielson
The production of terephthalic acid (TPA) by oxidation of p-xylene is an important industrial process because high purity TPA is required for the synthesis of polyethylene terephthalate, the primary polymer used to make plastic beverage bottles. Few separation methods have been published that aim to separate TPA from eight major aromatic acid impurities. This work describes a "green" micellar liquid chromatography (MLC) method using a C18 column (100×2.1mm, 3.5μm), an acidic 1% sodium dodecyl sulfate (SDS) mobile phase, and a simple step flow rate gradient to separate TPA and eight impurities in less than 20min...
March 31, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28256053/making-inroads-to-the-cure-barriers-to-clinical-trial-enrollment-in-hematopoietic-cell-transplantation
#18
REVIEW
Michael Byrne, Nathalie Danielson, Amanda Harris, Bipin N Savani
A significant barrier to advancing the standard of care for patients with hematologic malignancies undergoing stem cell transplantation is access and willingness to participate in clinical trials. The importance of clinical trial enrollment is magnified in an era of targeted therapies, accelerated drug discovery, and investment by the pharmaceutical industry. As disease targets are identified, novel therapies are being evaluated in efforts to reduce treatment-related toxicity and improve progression-free and overall survival...
March 3, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28254245/design-of-a-multisite-study-assessing-the-impact-of-tic-disorders-on-individuals-families-and-communities
#19
E F Augustine, H R Adams, R H Bitsko, E van Wijngaarden, A H Claussen, A Thatcher, C E Hanks, A B Lewin, T G O'Connor, A Vierhile, M L Danielson, R Kurlan, T K Murphy, J W Mink
BACKGROUND: Tic disorders, including Tourette syndrome, are complex, multisymptom diseases, yet the impact of these disorders on affected children, families, and communities is not well understood. METHODS: To improve the understanding of the impacts of Tourette syndrome, two research groups conducted independent cross-sectional studies using qualitative and quantitative measures. They focused on similar themes, but distinct scientific objectives, and the sites collaborated to align methods of independent research proposals with the aim of increasing the analyzable sample size...
March 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28248246/let-there-be-light
#20
REVIEW
Doroteya Raykova, Björn Koos, Anna Asplund, Márton Gelléri, Ylva Ivarsson, U Helena Danielson, Ola Söderberg
The invention of the microscope has been fundamental for the understanding of tissue architecture and subcellular structures. With the advancement of higher magnification microscopes came the development of various molecular biology tools such as Förster resonance energy transfer (FRET) and in situ proximity ligation assay (in situ PLA) to monitor protein interactions. Microscopy has become a commonly used method for the investigation of molecular events within the cell, for the identification of key players in signaling networks, and the activation of these pathways...
November 29, 2016: Proteomes
keyword
keyword
26247
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"