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https://www.readbyqxmd.com/read/28630507/analysis-of-the-student-experience-in-an-attending-pharmacist-model-general-medicine-advanced-pharmacy-practice-experience
#1
Teresa A O'Sullivan, Carmen Lau, Erin Sy, Hana Moogk, Stanley S Weber, Jennifer Danielson
Objective. To characterize and determine the quality of the student experience in an attending pharmacist model (APM). Methods. In-depth interviews were conducted with students completing an advanced pharmacy practice experience (APPE) at two general medicine services using the APM over a 2-year time period. Quantitative information about student learning and interprofessional interactions were extracted from student evaluations of the site. Data from the mixed model were analyzed to identify strengths of the APM and areas needing improvement...
May 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28621755/biophysical-mode-of-action-and-selectivity-analysis-of-allosteric-inhibitors-of-hepatitis-c-virus-hcv-polymerase
#2
Eldar Abdurakhmanov, Sara Øie Solbak, U Helena Danielson
Allosteric inhibitors of hepatitis C virus (HCV) non-structural protein 5B (NS5B) polymerase are effective for treatment of genotype 1, although their mode of action and potential to inhibit other isolates and genotypes are not well established. We have used biophysical techniques and a novel biosensor-based real-time polymerase assay to investigate the mode-of-action and selectivity of four inhibitors against enzyme from genotypes 1b (BK and Con1) and 3a. Two thumb inhibitors (lomibuvir and filibuvir) interacted with all three NS5B variants, although the affinities for the 3a enzyme were low...
June 16, 2017: Viruses
https://www.readbyqxmd.com/read/28613836/design-and-performance-of-a-novel-interface-for-combined-matrix-assisted-laser-desorption-ionization-at-elevated-pressure-and-electrospray-ionization-with-orbitrap-mass-spectrometry
#3
Mikhail E Belov, Shane R Ellis, Marialaura Dilillo, Martin R L Paine, William F Danielson, Gordon A Anderson, Eric L De Graaf, Gert B Eijkel, Ron M A Heeren, Liam A McDonnell
Matrix-Assisted Laser Desorption Ionization, MALDI, has been increasingly used in a variety of biomedical applications, including tissue imaging of clinical tissue samples, and in drug discovery and development. These studies strongly depend on the performance of the analytical instrumentation and would drastically benefit from improved sensitivity, reproducibility and mass / spatial resolution. In this work, we report on a novel combined MALDI/ESI interface, which was coupled to different Orbitrap mass spectrometers (Elite™ and Q Exactive™ Plus) and extensively characterized with peptide and protein standards, and in tissue imaging experiments...
June 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28613114/enhancing-accessibility-for-students-with-decoding-difficulties-on-large-scale-reading-assessments
#4
Allison Gruner Gandhi, Burhan Ogut, Laura Stein, Robin Bzura, Louis Danielson
This study reports findings from studies examining potential read-aloud accommodations on standardized reading comprehension assessments for students with decoding difficulties. Three types of accommodations were evaluated: question stems and answer options read aloud; question stems, answer options, and proper nouns read aloud; and full read-aloud. Drawing from a sample of 207 fourth-grade students with and without decoding difficulties, we used 3-level hierarchical linear modeling to assess whether there were significant differences between students with and without decoding difficulties in the effect of each accommodation relative to no accommodation...
June 1, 2017: Journal of Learning Disabilities
https://www.readbyqxmd.com/read/28599038/albumin-for-prehospital-fluid-resuscitation-of-hemorrhagic-shock-in-tactical-combat-casualty-care
#5
Nicholas M Studer, Michael D April, F Bowling, Paul D Danielson, Andrew P Cap
Optimal fluid resuscitation on the battlefield in the absence of blood products remains unclear. Contemporary Combat medics are generally limited to hydroxyethyl starch or crystalloid solutions, both of which present significant drawbacks. Obtaining US Food and Drug Administration (FDA)-approved freeze-dried plasma (FDP) is a top casualty care research priority for the US Military. Interest in this agent reflects a desire to simultaneously expand intravascular volume and address coagulopathy. The history of FDP dates to the Second World War, when American expeditionary forces used this agent frequently...
2017: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/28594439/genetic-and-psychosocial-predictors-of-alcohol-use-trajectories-among-disaster-exposed-adolescents
#6
Kaitlin Bountress, Carla Kmett Danielson, Vernell Williamson, Vladimir Vladmirov, Joel Gelernter, Kenneth Ruggiero, Ananda Amstadter
BACKGROUND AND OBJECTIVES: Adolescent alcohol misuse is associated with numerous long-term adverse outcomes, so we examined predictors of alcohol use among disaster-exposed adolescents, a group at-risk for alcohol misuse. METHODS: The current study (n = 332) examined severity of tornado-related exposure, posttraumatic stress disorder (PTSD) symptoms, emotional support, and a genetic risk sum score (GRSS) as predictors of alcohol use trajectories. RESULTS: Severity of exposure interacted with the GRSS to predict both intercept (12-month follow up quantity of alcohol use) and growth rate...
June 8, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28590996/helicopter-transport-from-the-scene-of-injury-are-there-improved-outcomes-for-pediatric-trauma-patients
#7
Sandra M Farach, Nebbie E Walford, Lindsey Bendure, Ernest K Amankwah, Paul D Danielson, Nicole M Chandler
BACKGROUND: There is conflicting data to support the routine use of helicopter transport (HT) for the transfer of trauma patients. The purpose of this study was to evaluate outcomes for trauma patients transported via helicopter from the scene of injury to a regional pediatric trauma center. METHODS: The institutional trauma registry was queried for trauma patients presenting from January 2000 through March 2012. Of 9119 patients, 1709 patients who presented from the scene were selected for further evaluation...
June 6, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28545490/glutamate-signaling-through-the-nmda-receptor-reduces-the-expression-of-scleraxis-in-plantaris-tendon-derived-cells
#8
Christoph Spang, Ludvig J Backman, Sandrine Le Roux, Jialin Chen, Patrik Danielson
BACKGROUND: A body of evidence demonstrating changes to the glutaminergic system in tendinopathy has recently emerged. This hypothesis was further tested by studying the effects of glutamate on the tenocyte phenotype, and the impact of loading and exposure to glucocorticoids on the glutamate signaling machinery. METHODS: Plantaris tendon tissue and cultured plantaris tendon derived cells were immunohisto-/cytochemically stained for glutamate, N-Methyl-D-Aspartate receptor 1 (NMDAR1) and vesicular glutamate transporter 2 (VGluT2)...
May 25, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28538643/immature-patients-in-a-mature-system-regional-analysis-of-florida-s-pediatric-trauma-system
#9
Christopher W Snyder, Nicole M Chandler, Cristen N Litz, Etienne E Pracht, Paul D Danielson, David J Ciesla
BACKGROUND: The state of Florida's trauma system is organized into seven regions, two of which lack designated pediatric trauma centers. Injured children residing in these regions often require transfer out of their home region for definitive care. The purpose of this study was to evaluate the effectiveness and efficiency of the current regionalization approach, focusing on variations between regions. METHODS: Using the Florida Agency for Health Care Administration database, we identified all trauma patients 15 years old or younger admitted between 2009 and 2014...
May 22, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28528712/timing-of-antimicrobial-prophylaxis-and-infectious-complications-in-pediatric-patients-undergoing-appendectomy
#10
Cristen N Litz, Jessica B Asuncion, Paul D Danielson, Nicole M Chandler
PURPOSE: Antibiotic administration within one hour prior to incision is a common quality metric; however, antibiotics are typically started at the time of diagnosis in pediatric patients with acute appendicitis. The purpose was to determine if antibiotic administration within one hour prior to incision reduces the incidence of surgical site infections (SSI) in pediatric patients with acute appendicitis started on parenteral antibiotics upon diagnosis. METHODS: A retrospective review was performed of 478 patients aged 0-18years who underwent appendectomy for acute appendicitis from 7/2013 to 4/2015...
May 11, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28518129/cardiac-muscle-cell-based-actuator-and-self-stabilizing-biorobot-part-2
#11
Neerajha Nagarajan, Merrel T Holley, Christian Danielson, Kidong Park, Pinar Zorlutuna
In recent years, hybrid devices that consist of a living cell or tissue component integrated with a synthetic mechanical backbone have been developed. These devices, called biorobots, are powered solely by the force generated from the contractile activity of the living component and, due to their many inherent advantages, could be an alternative to conventional fully artificial robots. Here, we describe the methods to seed and characterize a biological actuator and a biorobot that was designed, fabricated, and functionalized in the first part of this two-part article...
May 9, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28504284/fabrication-and-characterization-of-self-folding-thermoplastic-sheets-using-unbalanced-thermal-shrinkage
#12
Christian Danielson, Ali Mehrnezhad, Ashkan YekrangSafakar, Kidong Park
Self-folding or micro-origami technologies are actively investigated as a novel manufacturing process to fabricate three-dimensional macro/micro-structures. In this paper, we present a simple process to produce a self-folding structure with a biaxially oriented polystyrene sheet (BOPS) or Shrinky Dinks. A BOPS sheet is known to shrink to one-third of its original size in plane, when it is heated above 160 °C. A grid pattern is engraved on one side of the BOPS film with a laser engraver to decrease the thermal shrinkage of the engraved side...
June 14, 2017: Soft Matter
https://www.readbyqxmd.com/read/28502321/cytomegalovirus-in-the-human-dentate-gyrus-and-its-impact-on-neural-progenitor-cells-report-of-two-cases
#13
Ju-Yoon Yoon, Brett Danielson, Derek Mathis, Jason Karamchandani, David G Munoz
Congenital cytomegalovirus (CMV) infection in the 2nd and 3rd trimester results in catastrophic CNS abnormalities. This susceptibility is thought to result from the high proportion of neural stem cells in the developing brain. In immunocompromised adults, CNS infection by CMV preferentially affects ependymal surfaces, from where it expands to involve the parenchyma. Experimental models of murine CMV infection demonstrate viral tropism for the dentate gyrus (DG) and subventricular zone, the areas in which adult neurogenesis occurs...
May 15, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28501162/solidification-of-floating-organic-droplet-in-dispersive-liquid-liquid-microextraction-as-a-green-analytical-tool
#14
REVIEW
Fotouh R Mansour, Neil D Danielson
Dispersive liquid-liquid microextraction (DLLME) is a special type of microextraction in which a mixture of two solvents (an extracting solvent and a disperser) is injected into the sample. The extraction solvent is then dispersed as fine droplets in the cloudy sample through manual or mechanical agitation. Hence, the sample is centrifuged to break the formed emulsion and the extracting solvent is manually separated. The organic solvents commonly used in DLLME are halogenated hydrocarbons that are highly toxic...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28481062/preclinical-transgenic-and-patient-derived-xenograft-models-recapitulate-the-radiological-features-of-human-adamantinomatous-craniopharyngioma
#15
Jessica K R Boult, John R Apps, Annett Hölsken, J Ciaran Hutchinson, Carreno Gabriela, Laura S Danielson, Laura M Smith, Tobias Bäuerle, Rolf Buslei, Michael Buchfelder, Alex K Virasami, Alexander Koers, Owen J Arthurs, Thomas S Jacques, Louis Chesler, Juan Pedro Martinez-Barbera, Simon P Robinson
AIM: To assess the clinical relevance of transgenic and patient-derived xenograft models of adamantinomatous craniopharyngioma (ACP) using serial magnetic resonance imaging (MRI) and high resolution post-mortem micro-computed tomography (μ-CT), with correlation with histology and human ACP imaging. METHODS: The growth patterns and radiological features of tumours arising in Hesx1(Cre/+) ;Ctnnb1(l) °(x(ex3)/+) transgenic mice, and of patient-derived ACP xenografts implanted in the cerebral cortex, were monitored longitudinally in vivo with anatomical and functional MRI, and by ex vivo μ-CT at study end...
May 8, 2017: Brain Pathology
https://www.readbyqxmd.com/read/28472513/insights-from-engineering-the-affibody-fc-interaction-with-a-computational-experimental-method
#16
Masoumeh Nosrati, Sara Solbak, Olle Nordesjö, Mikael Nissbeck, Daniel F A R Dourado, Ken G Andersson, Mohammad Reza Housaindokht, John Löfblom, Anders Virtanen, U Helena Danielson, Samuel Coulbourn Flores
The interaction between the Staphylococcal Protein A (SpA) domain B (the basis of the Affibody) molecule and the Fc of IgG is key to the use of Affibodies in affinity chromatography and in potential therapies against certain inflammatory diseases. Despite its importance and four-decade history, to our knowledge this interaction has never been affinity matured. We elucidate reasons why single-substitutions in the SpA which improve affinity to Fc may be very rare, and also discover substitutions which potentially serve several engineering purposes...
May 3, 2017: Protein Engineering, Design & Selection: PEDS
https://www.readbyqxmd.com/read/28471341/psychometrics-of-a-child-report-measure-of-maternal-support-following-disclosure-of-sexual-abuse
#17
Daniel W Smith, Genelle K Sawyer, Nicholas C Heck, Kristyn Zajac, David Solomon, Shannon Self-Brown, Carla K Danielson, M Elizabeth Ralston
The study examined a new child report measure of maternal support following child sexual abuse. One hundred and forty-six mother-child dyads presenting for a forensic evaluation completed assessments including standardized measures of adjustment. Child participants also responded to 32 items considered for inclusion in a new measure, the Maternal Support Questionnaire-Child Report (MSQ-CR). Exploratory factor analysis of the Maternal Support Questionnaire-Child Report resulted in a three factor, 20-item solution: Emotional Support (9 items), Skeptical Preoccupation (5 items), and Protection/Retaliation (6 items)...
April 2017: Journal of Child Sexual Abuse
https://www.readbyqxmd.com/read/28449373/biophysical-analysis-of-the-dynamics-of-calmodulin-interactions-with-neurogranin-and-ca2-calmodulin-dependent-kinase-ii
#18
Christian Seeger, Vladimir O Talibov, U Helena Danielson
Calmodulin (CaM) functions depend on interactions with CaM-binding proteins, regulated by Ca2+. Induced structural changes influence the affinity, kinetics, and specificities of the interactions. The dynamics of CaM interactions with neurogranin (Ng) and the CaM-binding region of Ca2+/calmodulin-dependent kinase II (CaMKII290-309 ) have been studied using biophysical methods. These proteins have opposite Ca2+ dependencies for CaM binding. Surface plasmon resonance biosensor analysis confirmed that Ca2+ and CaM interact very rapidly, and with moderate affinity ( KDSPR=3μM)...
April 27, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28433090/neural-biomarker-and-early-temperament-predict-increased-internalizing-symptoms-after-a%C3%A2-natural-disaster
#19
Alexandria Meyer, Carla Kmett Danielson, Allison P Danzig, Vickie Bhatia, Sarah R Black, Evelyn Bromet, Gabrielle Carlson, Greg Hajcak, Roman Kotov, Daniel N Klein
OBJECTIVE: Although most people will experience a traumatic event at some point in their life, only some will develop significant psychological symptoms in the aftermath. In the current study, we use a preexisting longitudinal study located in Long Island to examine the impact of Hurricane Sandy on internalizing symptoms in a large sample of children. We focused on temperamental fear and a biomarker of risk for anxiety, the error-related negativity (ERN). The ERN is a negative deflection in the event-related potential (ERP) occurring when individuals make mistakes and is increased in anxious individuals...
May 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28432815/immunoassays-for-the-quantification-of-alk-and-phosphorylated-alk-support-the-evaluation-of-on-target-alk-inhibitors-in-neuroblastoma
#20
Elizabeth R Tucker, Jennifer R Tall, Laura S Danielson, Sharon Gowan, Yann Jamin, Simon P Robinson, Udai Banerji, Louis Chesler
Targeted inhibition of Anaplastic Lymphoma Kinase (ALK) is a successful approach for the treatment of many ALK-aberrant malignancies, however the presence of resistant mutations necessitates both the development of more potent compounds and pharmacodynamic methods with which to determine their efficacy. We describe immunoassays designed to quantitate phosphorylation of ALK, and their use in preclinical models of neuroblastoma, a pediatric malignancy in which gain-of-function ALK mutations predict a poor overall outcome to conventional treatment...
April 22, 2017: Molecular Oncology
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