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https://www.readbyqxmd.com/read/29688882/disparity-in-public-funding-of-therapies-for-metastatic-castrate-resistant-prostate-cancer-across-canadian-provinces
#1
Dixon T S Woon, Thenappan Chandrasekar, Lorne Aaron, Naveen S Basappa, Kim N Chi, Henry J Conter, Brita Danielson, Sebastien J Hotte, Shawn Malone, Fred Saad, Bobby Shayegan, Laura Park-Wyllie, Robert J Hamilton
INTRODUCTION: Treatment using abiraterone acetate, enzalutamide, cabazitaxel, and radium-223 (Ra-223) improve overall survival (OS) and quality of life for patients with metastatic castrate-resistant prostate cancer (mCRPC). Despite their proven benefits, access to these therapies is not equal across Canada. METHODS: We describe provincial differences in access to approved mCRPC therapies. Data sources include the pan-Canadian Oncology Drug Review database, provincial cancer care resources, and correspondence with pharmaceutical companies...
April 12, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29670495/impact-of-pilates-exercise-in-multiple-sclerosis-a-randomized-controlled-trial
#2
Whitney R D Duff, Justin W Andrushko, Doug W Renshaw, Philip D Chilibeck, Jonathan P Farthing, Jana Danielson, Charity D Evans
Background: Pilates is a series of exercises based on whole-body movement and may improve mobility in people with multiple sclerosis (MS). The purpose of this study was to determine the effect of Pilates on walking performance in people with MS. Methods: 30 individuals with MS who were not restricted to a wheelchair or scooter (Patient-Determined Disease Steps scale score <7) were randomized to receive Pilates (twice weekly) and massage therapy (once weekly) or once-weekly massage therapy only (control group)...
March 2018: International Journal of MS Care
https://www.readbyqxmd.com/read/29653440/long-term-outcome-after-dynamic-graciloplasty-for-treatment-of-persistent-fecal-incontinence-in-patients-with-anorectal-malformations
#3
Johan Danielson, Urban Karlbom, Tomas Wester, Wilhelm Graf
PURPOSE:  Dynamic graciloplasty (DGP) has been used to treat severe fecal incontinence since the 1980s. Previous studies have shown an inferior outcome in patients with anorectal malformations (ARMs). Our experience has been that DGP has been appreciated by ARM -patients. The objective of the study was to evaluate the long-term outcome of DGP in our patients with ARM compared with patients with other underlying conditions. MATERIALS AND METHODS:  Twenty-three patients operated with DGP at our institution from 1996 to 2010 were sent validated bowel function and quality of life questionnaires...
April 13, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29644452/implications-of-non-accidental-trauma-on-resource-utilization-and-outcomes
#4
Cristen N Litz, Ernest K Amankwah, Paul D Danielson, Nicole M Chandler
PURPOSE: The purpose was to compare the resource utilization and outcomes between patients with suspected (SUSP) and confirmed (CONF) non-accidental trauma (NAT). METHODS: The institutional trauma registry was reviewed for patients aged 0-18 years presenting from 2007 to 2012 with a diagnosis of suspicion for NAT. Patients with suspected and confirmed NAT were compared. RESULTS: There were 281 patients included. CONF presented with a higher heart rate (142 ± 27 vs 128 ± 23 bpm, p < 0...
April 11, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29605239/looking-for-light-in-the-din-an-examination-of-the-circadian-disrupting-properties-of-a-medical-intensive-care-unit
#5
Samantha J Danielson, Charles A Rappaport, Michael K Loher, Brian K Gehlbach
OBJECTIVE: Critically ill patients exhibit profound disturbances of circadian rhythmicity, most commonly in the form of a phase delay. We investigated the specific zeitgeber properties of a medical intensive care unit to develop a model that explained these abnormalities. RESEARCH METHODOLOGY: Prospective, observational study conducted during 2013-2014. Twenty-four-hour ambient light (lux, 672 hours) and sound pressure levels (dBA, 504 hours) were measured in patient rooms...
March 28, 2018: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/29576276/liquid-chromatography-with-alkylammonium-formate-ionic-liquid-mobile-phases-and-fluorescence-detection
#6
Neil D Danielson, Fotouh R Mansour, Ling Zhou, Casey V Connell, Erin M Dotlich, Justin N Gibler, Blake E Norman, Shau Grossman, Wenjun Wei, Ying Zhang
Fluorescence detection of various pharmaceuticals and the amino acid tryptophan (low molecular weight organic compounds) as well as the enzyme lactate dehydrogenase LDH (high molar mass compound) has been studied in aqueous solutions using alkyl ammonium formate ionic liquids as the primary solvent component. It was expected that the high viscosity of such ionic liquid-water mixtures would enhance fluorescence. Pharmaceuticals such as riboflavin and naproxen showed no such enhancement in the presence of ethylammonium formate (EAF) or isopropylammonium formate (IPAF) but the fluorescence of warfarin was substantially enhanced by a factor of 4 with 80% EAF and a factor of 7 with 70% IPAF...
March 14, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29575270/the-immunomodulatory-role-of-tumour-derived-extracellular-vesicles-in-colorectal-cancer
#7
Stephanie Manning, Kirsty M Danielson
Colorectal cancer (CRC) is one of the most prevalent cancers worldwide with rising mortality rates predicted in the coming decades. In light of this, there is a continued need for improvement in our understanding of CRC biology and the development of novel treatment options. Tumour-derived extracellular vesicles (tEVs) have emerged as both novel cancer biomarkers and functional mediators of carcinogenesis. tEVs are released by tumour cells in abundance and play an important role in mediating tumour cell - immune cell interactions in the tumour microenvironment...
March 25, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29534799/solvent-terminated-dispersive-liquid-liquid-microextraction-a-tutorial
#8
REVIEW
Fotouh R Mansour, Neil D Danielson
Solvent-terminated dispersive liquid-liquid microextraction (ST-DLLME) is a special mode of DLLME in which a demulsifying solvent is injected into the cloudy mixture of sample/extractant to break the emulsion and induce phase separation. The demulsification process starts by flocculation of the dispersed microdroplets by Ostwald ripening or coalescence to form larger droplets. Then, the extractant either floats or sinks depending on its density as compared with that for the aqueous sample. The demulsifier should have high surface activity and low surface tension in order to be capable of inducing phase separation...
August 3, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29506040/factors-affecting-population-dynamics-of-thrips-vectors-of-soybean-vein-necrosis-virus
#9
Stacy Keough, Jonathan Danielson, Jordan M Marshall, Doris Lagos-Kutz, David J Voegtlin, Rajagopalbabu Srinivasan, Punya Nachappa
Thrips-infesting soybeans were considered of minor economic importance, but recent evidence of their ability to transmit a newly identified soybean virus, Soybean vein necrosis virus (SVNV), has raised their profile as pests. Season-long surveys were conducted using suction traps to determine the effects of temperature and precipitation on the spatiotemporal patterns of three vector species of SVNV, Neohydatothrips variabilis (Beach) (Thysanoptera: Thripidae) (soybean thrips), Frankliniella tritici (Fitch) (Thysanoptera: Thripidae) (eastern flower thrips), and Frankliniella fusca (Hinds) (Thysanoptera: Thripidae) (tobacco thrips) in soybean fields in Indiana in 2013 and 2014...
March 1, 2018: Environmental Entomology
https://www.readbyqxmd.com/read/29505396/impulsivity-and-comorbid-ptsd-binge-drinking
#10
Jesse Walker, Kaitlin E Bountress, Casey D Calhoun, Isha W Metzger, Zachary Adams, Ananda Amstadter, Suzanne Thomas, Carla Kmett Danielson
OBJECTIVE: Trauma exposure is common, with estimates of 28 to 90% of adults reporting at least one traumatic event over their lifetime. Those exposed to traumatic events are at risk for alcohol misuse (i.e., binge drinking), posttraumatic stress disorder (PTSD), or both. A potential underlying mechanism for this comorbidity is increased impulsivity-the tendency to act rashly. Little work to date has examined the impact of different impulsogenic traits on this comorbidity. METHODS: This study (n = 162) investigated trauma-exposed young adults (age 21-30) who had endorsed a lifetime interpersonal trauma...
March 5, 2018: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/29491502/third-party-onboarding-organizations-as-gatekeepers-for-student-placement-decisions
#11
Jennifer Danielson, Courtney Kraus, Curtis G Jefferson, Anita J Cleven, Luke E Rice, Teresa A O'Sullivan
Health system human resource departments are putting new requirements, paperwork, and processes in place to meet new Joint Commission standards for treating students like employees who onboard at the beginning of employment. These processes have significantly increased the workload of experiential education offices and present an additional burden to students. In an attempt to streamline these processes, health systems are contracting with third-party tracking and placement organizations. Converting this process to an electronic one (such as what third-party organizations offer) could present advantages; however, there are many concerns about going through a third-party organization that could control placement decisions...
February 2018: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/29490009/metastatic-group-3-medulloblastoma-is-driven-by-prune1-targeting-nme1-tgf-%C3%AE-otx2-snail-via-pten-inhibition
#12
Veronica Ferrucci, Pasqualino de Antonellis, Francesco Paolo Pennino, Fatemeh Asadzadeh, Antonella Virgilio, Donatella Montanaro, Aldo Galeone, Iolanda Boffa, Ida Pisano, Iolanda Scognamiglio, Luigi Navas, Donatella Diana, Emilia Pedone, Sara Gargiulo, Matteo Gramanzini, Arturo Brunetti, Laura Danielson, Marianeve Carotenuto, Lucia Liguori, Antonio Verrico, Lucia Quaglietta, Maria Elena Errico, Valentina Del Monaco, Valeria D'Argenio, Felice Tirone, Angela Mastronuzzi, Vittoria Donofrio, Felice Giangaspero, Daniel Picard, Marc Remke, Livia Garzia, Craig Daniels, Olivier Delattre, Fredrik J Swartling, William A Weiss, Francesco Salvatore, Roberto Fattorusso, Louis Chesler, Michael D Taylor, Giuseppe Cinalli, Massimo Zollo
Genetic modifications during development of paediatric groups 3 and 4 medulloblastoma are responsible for their highly metastatic properties and poor patient survival rates. PRUNE1 is highly expressed in metastatic medulloblastoma group 3, which is characterized by TGF-β signalling activation, c-MYC amplification, and OTX2 expression. We describe the process of activation of the PRUNE1 signalling pathway that includes its binding to NME1, TGF-β activation, OTX2 upregulation, SNAIL (SNAI1) upregulation, and PTEN inhibition...
February 27, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29477077/pan-ns3-protease-inhibitors-of-hepatitis-c-virus-based-on-an-r-3-elongated-pyrazinone-scaffold
#13
Anna Karin Belfrage, Eldar Abdurakhmanov, Eva Åkerblom, Peter Brandt, Hiba Alogheli, Johan Neyts, U Helena Danielson, Anja Sandström
Herein, we present the design and synthesis of 2(1H)-pyrazinone based HCV NS3 protease inhibitors and show that elongated R3 urea substituents were associated with increased inhibitory potencies over several NS3 protein variants. The inhibitors are believed to rely on β-sheet mimicking hydrogen bonds which are similar over different genotypes and current drug resistant variants and correspond to the β-sheet interactions of the natural peptide substrate. Inhibitor 36, for example, with a urea substituent including a cyclic imide showed balanced nanomolar inhibitory potencies against genotype 1a, both wild-type (Ki  = 30 nM) and R155K (Ki  = 2 nM), and genotype 3a (Ki  = 5 nM)...
February 13, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29474704/renewed-interest-in-whole-plant-physiology-sheds-light-on-the-complexity-of-plant-stress-response-architecture
#14
Juliana S Medeiros, Sharon C Danielson
No abstract text is available yet for this article.
February 21, 2018: Tree Physiology
https://www.readbyqxmd.com/read/29468737/school-based-study-found-that-physical-activity-and-aerobic-fitness-predicted-increases-in-total-body-fat-and-abdominal-fat-at-a-mean-age-of-9-8-years
#15
Anton Danielson, Ola Thorsson, Magnus K Karlsson, Per Wollmer, Lars B Andersen, Magnus Dencker
AIM: We assessed if baseline measurements of physical activity, aerobic fitness, body fat and abdominal fat were predictors of changes in body fat measurements over a two-year period. METHODS: The study comprised of 204 children aged 9.8 ±0.6 years with a normal body mass distribution, who recruited from four schools in middle-class areas of Malmö, Sweden, from 2001-2004. Peak oxygen uptake and physical activity were measured at baseline. Body fat was measured by dual-energy x-ray absorptiometry at baseline and two years later...
February 22, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29466001/introduction-of-intrinsic-kinetics-of-protein-ligand-interactions-and-their-implications-for-drug-design
#16
Vaida Linkuvienė, Vladimir O Talibov, U Helena Danielson, Daumantas Matulis
Structure-kinetic relationship analyses and identification of dominating interactions for optimisation of lead compounds should ideally be based on intrinsic rate constants instead of the more easily accessible observed kinetic constants, which account also for binding-linked reactions. The intrinsic rate constants for sulfonamide inhibitors and pharmacologically relevant isoforms of carbonic anhydrase were determined by a novel surface plasmon resonance (SPR) biosensor-based approach, using chemodynamic analysis of binding-linked pH-dependent effects...
February 21, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29401429/helical-propensity-affects-the-conformational-properties-of-the-denatured-state-of-cytochrome-c
#17
Travis A Danielson, Bruce E Bowler
Changing the helical propensity of a polypeptide sequence might be expected to affect the conformational properties of the denatured state of a protein. To test this hypothesis, alanines at positions 83 and 87 near the center of helix 3 of cytochrome c' from Rhodopseudomonas palustris were mutated to serine to decrease the stability of this helix. A set of 13 single histidine variants in the A83S/A87S background were prepared to permit assessment of the conformational properties of the denatured state using histidine-loop formation in 3 M guanidine hydrochloride...
January 23, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29388133/extracellular-rna-isolation-from-cell-culture-supernatant
#18
Sawen Bakr, Bridget Simonson, Kirsty M Danielson, Saumya Das
Extracellular RNAs are emerging as novel biomarkers and mediators of intercellular communication. Various methods to isolate RNA from biofluids and cell culture supernatants have been previously used by investigators. Here, we describe several standardized protocols for the isolation of RNAs from cell culture supernatants that utilize commercially available kits and reagents.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29382370/supraclavicular-subclavian-access-for-sapien-transcatheter-aortic-valve-replacement-a-novel-approach
#19
Thom G Dahle, Nathaniel J Castro, Brian M Stegman, Jacob R Dutcher, John M Teskey, Wade T Schmidt, Daren S Danielson, Sara J Dezell, Virginia B Daniels, Daniel J Tiede
BACKGROUND: Within the trans-subclavian approach, procedural techniques can vary widely, and reported access generally refers to an infraclavicular axillary approach. We describe and report the use of a novel supraclavicular true subclavian approach for transcatheter aortic valve replacement (TAVR) exclusively for implantation of Sapien 3 valves. CASE PRESENTATION: We report our first five consecutive patients undergoing TAVR with a Sapien 3 valve using a standardized subclavian approach at a single center...
January 30, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29363986/prevalence-of-parent-reported-adhd-diagnosis-and-associated-treatment-among-u-s-children-and-adolescents-2016
#20
Melissa L Danielson, Rebecca H Bitsko, Reem M Ghandour, Joseph R Holbrook, Michael D Kogan, Stephen J Blumberg
The purpose of this study is to estimate the national prevalence of parent-reported attention deficit/hyperactivity disorder (ADHD) diagnosis and treatment among U.S. children 2-17 years of age using the 2016 National Survey of Children's Health (NSCH). The NSCH is a nationally representative, cross-sectional survey of parents regarding their children's health that underwent a redesign before the 2016 data collection. It included indicators of lifetime receipt of an ADHD diagnosis by a health care provider, whether the child currently had ADHD, and receipt of medication and behavioral treatment for ADHD...
March 2018: Journal of Clinical Child and Adolescent Psychology
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