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https://www.readbyqxmd.com/read/28813772/pilot-study-to-determine-safety-and-efficacy-of-paclitaxel-infusion-in-de-novo-peripheral-lesions-using-the-atrium-clearway-balloon
#1
Joseph Anderson, Laura Danielson, Jodan Anderson, Katie Pohlson, Tyler Remund, Chad Laurich, Greg Schultz, Angelo Santos, Gopinath Mani, Patrick Kelly, Andrea Shermann
OBJECTIVE: To evaluate the safety and efficacy of a one-time infusion of paclitaxel through an Atrium ClearWay balloon in infra inguinal de novo peripheral lesions. METHODS: This is a single-center prospective study looking at treatment of 50 limbs. Treatment includes standard infra inguinal endovascular revascularization followed by a pre-prescribed infusion of paclitaxel. Control is standard reintervention without subsequent paclitaxel infusion. Patients were followed at one, four, and 10 months with ankle-brachial index (ABI)s, arterial duplex of the treated limb, and Rutherford classification stage measured before and after procedures and at each follow-up...
March 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28758344/characterizing-the-inpatient-care-of-young-adults-experiencing-early-psychosis-a-medical-record-review
#2
Joseph H Puyat, Renata Kamieniecki, Brenda Vaughan, Tamara Mihic, Kofi Bonnie, Jeffrey Danielson, Sierra Williams
AIM: To characterize the inpatient care received by individuals experiencing early psychotic episodes in an inner city hospital. METHOD: Medical records of patients admitted between April 01, 2013, and March 31, 2015, to a psychiatric ward at an inner city hospital were retrospectively examined. Included in the study are patients who were 25 years of age or younger and were hospitalized for psychotic symptoms. Demographics and health service use were summarized using descriptive statistics...
July 31, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28748581/coronary-artery-calcium-may-stabilize-following-islet-cell-transplantation-in-patients-with-type-1-diabetes
#3
J M Madrigal, R S Monson, B Hatipoglu, J Oberholzer, G T Kondos, K A Varady, K K Danielson
Islet cell transplantation can functionally cure type 1 diabetes, and also improve carotid-intima media thickness. This study provides a preliminary description of changes in coronary artery calcium following islet transplantation, and associated factors. Coronary artery calcium was measured in 14 patients with type 1 diabetes (11 had measures both pre- and post-transplant [mean 2.3 years]) in the University of Illinois at Chicago's clinical trial. Multivariable mixed-effects linear regression of repeated measures was used to quantify calcium change, and determine if this change was longitudinally associated with risk/protective factors...
July 27, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28745624/cardiac-muscle-cell-based-actuator-and-self-stabilizing-biorobot-part-1
#4
Merrel T Holley, Neerajha Nagarajan, Christian Danielson, Pinar Zorlutuna, Kidong Park
Biological machines often referred to as biorobots, are living cell- or tissue-based devices that are powered solely by the contractile activity of living components. Due to their inherent advantages, biorobots are gaining interest as alternatives to traditional fully artificial robots. Various studies have focused on harnessing the power of biological actuators, but only recently studies have quantitatively characterized the performance of biorobots and studied their geometry to enhance functionality and efficiency...
July 11, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28736287/novel-approach-for-selective-reduction-of-nnn-in-cigarette-tobacco-filler-and-mainstream-smoke
#5
M Lusso, I Gunduz, A Kondylis, G Jaccard, L Ruffieux, F Gadani, K Lion, A Adams, W Morris, T Danielson, U Warek, J Strickland
Research conducted during past decades to reduce the level of the tobacco specific nitrosamine N-nitrosonornicotine (NNN) and its precursor nornicotine in tobacco yielded identification of three tobacco genes encoding for cytochrome P450 nicotine demethylases converting nicotine to nornicotine. We carried out trials to investigate the effect of using tobaccos containing three non-functional nicotine demethylase genes on the selective reduction of NNN in cigarette tobacco filler and mainstream smoke. Our results indicate that the presence of non-functional alleles of the three genes reduces the level of nornicotine and NNN in Burley tobacco by 70% compared to the level observed in currently available low converter (LC) Burley tobacco varieties...
July 20, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28732743/antimicrobial-stewardship-in-the-treatment-of-skin-and-soft-tissue-infections
#6
Julie A Gibbons, Hayden L Smith, Sudhir C Kumar, Katherine Johnson Duggins, Amanda M Bushman, Jayme M Danielson, William J Yost, Jonathan J Wadle
BACKGROUND: Research on treating skin and soft tissue infections (SSTI) has shown improved patient outcomes with effective pharmaceutic prescribing. Antimicrobial stewardship programs can reduce consequences of broad-spectrum antimicrobial administration in SSTI treatment. METHODS: Prospective and historic control data were collected during two 7-month periods. Intervention consisted of implementing a new SSTI evidence-based treatment algorithm and provider education, including calls and medical record notes targeted at physicians...
July 18, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28723824/a-national-profile-of-attention-deficit-hyperactivity-disorder-diagnosis-and-treatment-among-us-children-aged-2-to-5-years
#7
Melissa L Danielson, Susanna N Visser, Mary Margaret Gleason, Georgina Peacock, Angelika H Claussen, Stephen J Blumberg
OBJECTIVE: Clinical guidelines provide recommendations for diagnosis and treatment of attention-deficit hyperactivity disorder (ADHD), with specific guidance on caring for children younger than 6 years. This exploratory study describes ADHD diagnosis and treatment patterns among young children in the United States using 2 nationally representative parent surveys. METHODS: The National Survey of Children's Health (2007-2008, 2011-2012) was used to produce weighted prevalence estimates of current ADHD and ADHD medication treatment among US children aged 2 to 5 years...
July 14, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28693849/impact-of-outpatient-management-following-appendectomy-for-acute-appendicitis-an-acs-nsqip-p-analysis
#8
Cristen N Litz, Laurie Stone, Roberta Alessi, Nebbie E Walford, Paul D Danielson, Nicole M Chandler
BACKGROUND: In 2012, a same-day discharge protocol following appendectomy for acute appendicitis was initiated. Our objective was to determine the success of the protocol by reviewing the National Surgical Quality Improvement Program-Pediatric (NSQIP-P) outcomes following protocol development. METHODS: The 2015 NSQIP-P Participant Use Data File was queried to identify patients with acute appendicitis who underwent appendectomy. Outcomes were compared to institutional outcomes...
June 30, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28630507/analysis-of-the-student-experience-in-an-attending-pharmacist-model-general-medicine-advanced-pharmacy-practice-experience
#9
Teresa A O'Sullivan, Carmen Lau, Erin Sy, Hana Moogk, Stanley S Weber, Jennifer Danielson
Objective. To characterize and determine the quality of the student experience in an attending pharmacist model (APM). Methods. In-depth interviews were conducted with students completing an advanced pharmacy practice experience (APPE) at two general medicine services using the APM over a 2-year time period. Quantitative information about student learning and interprofessional interactions were extracted from student evaluations of the site. Data from the mixed model were analyzed to identify strengths of the APM and areas needing improvement...
May 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28621755/biophysical-mode-of-action-and-selectivity-analysis-of-allosteric-inhibitors-of-hepatitis-c-virus-hcv-polymerase
#10
Eldar Abdurakhmanov, Sara Øie Solbak, U Helena Danielson
Allosteric inhibitors of hepatitis C virus (HCV) non-structural protein 5B (NS5B) polymerase are effective for treatment of genotype 1, although their mode of action and potential to inhibit other isolates and genotypes are not well established. We have used biophysical techniques and a novel biosensor-based real-time polymerase assay to investigate the mode-of-action and selectivity of four inhibitors against enzyme from genotypes 1b (BK and Con1) and 3a. Two thumb inhibitors (lomibuvir and filibuvir) interacted with all three NS5B variants, although the affinities for the 3a enzyme were low...
June 16, 2017: Viruses
https://www.readbyqxmd.com/read/28613836/design-and-performance-of-a-novel-interface-for-combined-matrix-assisted-laser-desorption-ionization-at-elevated-pressure-and-electrospray-ionization-with-orbitrap-mass-spectrometry
#11
Mikhail E Belov, Shane R Ellis, Marialaura Dilillo, Martin R L Paine, William F Danielson, Gordon A Anderson, Erik L de Graaf, Gert B Eijkel, Ron M A Heeren, Liam A McDonnell
Matrix-Assisted Laser Desorption Ionization, MALDI, has been increasingly used in a variety of biomedical applications, including tissue imaging of clinical tissue samples, and in drug discovery and development. These studies strongly depend on the performance of the analytical instrumentation and would drastically benefit from improved sensitivity, reproducibility, and mass/spatial resolution. In this work, we report on a novel combined MALDI/ESI interface, which was coupled to different Orbitrap mass spectrometers (Elite and Q Exactive Plus) and extensively characterized with peptide and protein standards, and in tissue imaging experiments...
June 28, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28613114/enhancing-accessibility-for-students-with-decoding-difficulties-on-large-scale-reading-assessments
#12
Allison Gruner Gandhi, Burhan Ogut, Laura Stein, Robin Bzura, Louis Danielson
This study reports findings from studies examining potential read-aloud accommodations on standardized reading comprehension assessments for students with decoding difficulties. Three types of accommodations were evaluated: question stems and answer options read aloud; question stems, answer options, and proper nouns read aloud; and full read-aloud. Drawing from a sample of 207 fourth-grade students with and without decoding difficulties, we used 3-level hierarchical linear modeling to assess whether there were significant differences between students with and without decoding difficulties in the effect of each accommodation relative to no accommodation...
June 1, 2017: Journal of Learning Disabilities
https://www.readbyqxmd.com/read/28599038/albumin-for-prehospital-fluid-resuscitation-of-hemorrhagic-shock-in-tactical-combat-casualty-care
#13
Nicholas M Studer, Michael D April, F Bowling, Paul D Danielson, Andrew P Cap
Optimal fluid resuscitation on the battlefield in the absence of blood products remains unclear. Contemporary Combat medics are generally limited to hydroxyethyl starch or crystalloid solutions, both of which present significant drawbacks. Obtaining US Food and Drug Administration (FDA)-approved freeze-dried plasma (FDP) is a top casualty care research priority for the US Military. Interest in this agent reflects a desire to simultaneously expand intravascular volume and address coagulopathy. The history of FDP dates to the Second World War, when American expeditionary forces used this agent frequently...
December 0: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/28594439/genetic-and-psychosocial-predictors-of-alcohol-use-trajectories-among-disaster-exposed-adolescents
#14
Kaitlin Bountress, Carla Kmett Danielson, Vernell Williamson, Vladimir Vladmirov, Joel Gelernter, Kenneth Ruggiero, Ananda Amstadter
BACKGROUND AND OBJECTIVES: Adolescent alcohol misuse is associated with numerous long-term adverse outcomes, so we examined predictors of alcohol use among disaster-exposed adolescents, a group at-risk for alcohol misuse. METHODS: The current study (n = 332) examined severity of tornado-related exposure, posttraumatic stress disorder (PTSD) symptoms, emotional support, and a genetic risk sum score (GRSS) as predictors of alcohol use trajectories. RESULTS: Severity of exposure interacted with the GRSS to predict both intercept (12-month follow up quantity of alcohol use) and growth rate...
June 8, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28590996/helicopter-transport-from-the-scene-of-injury-are-there-improved-outcomes-for-pediatric-trauma-patients
#15
Sandra M Farach, Nebbie E Walford, Lindsey Bendure, Ernest K Amankwah, Paul D Danielson, Nicole M Chandler
BACKGROUND: There is conflicting data to support the routine use of helicopter transport (HT) for the transfer of trauma patients. The purpose of this study was to evaluate outcomes for trauma patients transported via helicopter from the scene of injury to a regional pediatric trauma center. METHODS: The institutional trauma registry was queried for trauma patients presenting from January 2000 through March 2012. Of 9119 patients, 1709 patients who presented from the scene were selected for further evaluation...
June 6, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28545490/glutamate-signaling-through-the-nmda-receptor-reduces-the-expression-of-scleraxis-in-plantaris-tendon-derived-cells
#16
Christoph Spang, Ludvig J Backman, Sandrine Le Roux, Jialin Chen, Patrik Danielson
BACKGROUND: A body of evidence demonstrating changes to the glutaminergic system in tendinopathy has recently emerged. This hypothesis was further tested by studying the effects of glutamate on the tenocyte phenotype, and the impact of loading and exposure to glucocorticoids on the glutamate signaling machinery. METHODS: Plantaris tendon tissue and cultured plantaris tendon derived cells were immunohisto-/cytochemically stained for glutamate, N-Methyl-D-Aspartate receptor 1 (NMDAR1) and vesicular glutamate transporter 2 (VGluT2)...
May 25, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28538643/immature-patients-in-a-mature-system-regional-analysis-of-florida-s-pediatric-trauma-system
#17
Christopher W Snyder, Nicole M Chandler, Cristen N Litz, Etienne E Pracht, Paul D Danielson, David J Ciesla
BACKGROUND: The state of Florida's trauma system is organized into seven regions, two of which lack designated pediatric trauma centers. Injured children residing in these regions often require transfer out of their home region for definitive care. The purpose of this study was to evaluate the effectiveness and efficiency of the current regionalization approach, focusing on variations between regions. METHODS: Using the Florida Agency for Health Care Administration database, we identified all trauma patients 15 years old or younger admitted between 2009 and 2014...
May 22, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28528712/timing-of-antimicrobial-prophylaxis-and-infectious-complications-in-pediatric-patients-undergoing-appendectomy
#18
Cristen N Litz, Jessica B Asuncion, Paul D Danielson, Nicole M Chandler
PURPOSE: Antibiotic administration within one hour prior to incision is a common quality metric; however, antibiotics are typically started at the time of diagnosis in pediatric patients with acute appendicitis. The purpose was to determine if antibiotic administration within one hour prior to incision reduces the incidence of surgical site infections (SSI) in pediatric patients with acute appendicitis started on parenteral antibiotics upon diagnosis. METHODS: A retrospective review was performed of 478 patients aged 0-18years who underwent appendectomy for acute appendicitis from 7/2013 to 4/2015...
May 11, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28518129/cardiac-muscle-cell-based-actuator-and-self-stabilizing-biorobot-part-2
#19
Neerajha Nagarajan, Merrel T Holley, Christian Danielson, Kidong Park, Pinar Zorlutuna
In recent years, hybrid devices that consist of a living cell or tissue component integrated with a synthetic mechanical backbone have been developed. These devices, called biorobots, are powered solely by the force generated from the contractile activity of the living component and, due to their many inherent advantages, could be an alternative to conventional fully artificial robots. Here, we describe the methods to seed and characterize a biological actuator and a biorobot that was designed, fabricated, and functionalized in the first part of this two-part article...
May 9, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28504284/fabrication-and-characterization-of-self-folding-thermoplastic-sheets-using-unbalanced-thermal-shrinkage
#20
Christian Danielson, Ali Mehrnezhad, Ashkan YekrangSafakar, Kidong Park
Self-folding or micro-origami technologies are actively investigated as a novel manufacturing process to fabricate three-dimensional macro/micro-structures. In this paper, we present a simple process to produce a self-folding structure with a biaxially oriented polystyrene sheet (BOPS) or Shrinky Dinks. A BOPS sheet is known to shrink to one-third of its original size in plane, when it is heated above 160 °C. A grid pattern is engraved on one side of the BOPS film with a laser engraver to decrease the thermal shrinkage of the engraved side...
June 14, 2017: Soft Matter
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