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https://www.readbyqxmd.com/read/27894765/outcome-in-adults-with-anorectal-malformations-in-relation-to-modern-classification-which-patients-do-we-need-to-follow-beyond-childhood
#1
Johan Danielson, Urban Karlbom, Wilhelm Graf, Tomas Wester
BACKGROUND/PURPOSE: Knowledge about the functional outcome in adults with anorectal malformations is essential to organize structured transition to adult care for this patient group. The aim of this study was to investigate the functional outcome and quality of life in adults with anorectal malformations characterized according to the Krickenbeck classification. METHODS: Of 256 patients diagnosed with anorectal malformations at our institution in 1961-1993, 203 patients could be traced and were invited to participate in the study...
November 15, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27852820/interpreting-the-prevalence-of-mental-disorders-in-children-tribulation-and-triangulation
#2
Joseph R Holbrook, Rebecca H Bitsko, Melissa L Danielson, Susanna N Visser
Knowledge on the prevalence of mental disorders among children informs the work of many health care providers, public health researchers, educators, and policy makers, and any single data source and study methodology can provide valuable insight. However, it is only after prevalence estimates from complementary studies are considered together that distinctions can be made to more deeply inform an assessment of community needs, including diagnosed prevalence versus underlying prevalence, differences between insured and uninsured populations, and how estimates change over time...
November 15, 2016: Health Promotion Practice
https://www.readbyqxmd.com/read/27814455/mobile-devices-for-the-remote-acquisition-of-physiological-and-behavioral-biomarkers-in-psychiatric-clinical-research
#3
Zachary W Adams, Erin A McClure, Kevin M Gray, Carla Kmett Danielson, Frank A Treiber, Kenneth J Ruggiero
Psychiatric disorders are linked to a variety of biological, psychological, and contextual causes and consequences. Laboratory studies have elucidated the importance of several key physiological and behavioral biomarkers in the study of psychiatric disorders, but much less is known about the role of these biomarkers in naturalistic settings. These gaps are largely driven by methodological barriers to assessing biomarker data rapidly, reliably, and frequently outside the clinic or laboratory. Mobile health (mHealth) tools offer new opportunities to study relevant biomarkers in concert with other types of data (e...
October 22, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27812183/imprime-pgg-mediated-anti-cancer-immune-activation-requires-immune-complex-formation
#4
Anissa S H Chan, Adria Bykowski Jonas, Xiaohong Qiu, Nadine R Ottoson, Richard M Walsh, Keith B Gorden, Ben Harrison, Peter J Maimonis, Steven M Leonardo, Kathleen E Ertelt, Michael E Danielson, Kyle S Michel, Mariana Nelson, Jeremy R Graff, Myra L Patchen, Nandita Bose
Imprime PGG (Imprime), an intravenously-administered, soluble β-glucan, has shown compelling efficacy in multiple phase 2 clinical trials with tumor targeting or anti-angiogenic antibodies. Mechanistically, Imprime acts as pathogen-associated molecular pattern (PAMP) directly activating innate immune effector cells, triggering a coordinated anti-cancer immune response. Herein, using whole blood from healthy human subjects, we show that Imprime-induced anti-cancer functionality is dependent on immune complex formation with naturally-occurring, anti-β glucan antibodies (ABA)...
2016: PloS One
https://www.readbyqxmd.com/read/27802519/antiapoptotic-effect-of-acetylcholine-in-fas-induced-apoptosis-in-human-keratocytes
#5
Marta Sloniecka, Ludvig J Backman, Patrik Danielson
Purpose: To investigate the possible antiapoptotic effect of acetylcholine (ACh) in Fas-mediated apoptosis of primary human keratocytes in vitro, and to explore the underlying mechanism. Methods: Primary human keratocytes were isolated from healthy corneas. Fas ligand (FasL) was used to induce apoptosis in keratocytes. Cell death was assessed by ELISA. Activity of caspase-3, -7, -8, and -9 was measured with luminescent caspase activity assays. Expression of nuclear factor-κB (NF-κB) gene was assessed with RT-quantitative (q)PCR...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27800610/lipocalin-2-ngal-attenuates-autophagy-to-exacerbate-cardiac-apoptosis-induced-by-myocardial-ischemia
#6
Hye Kyoung Sung, Yee Kwan Chan, Meng Han, James Won Suk Jahng, Erfei Song, Danielson Eric, Thorsten Berger, Tak W Mak, Gary Sweeney
Lipocalin-2 (Lcn2; also termed neutrophil gelatinase-associated lipocalin (NGAL)) levels correlate positively with heart failure (HF) yet mechanisms via which Lcn2 contributes to the pathogenesis of HF remian unclear. In this study we used coronary artery ligation surgery to induce ischemia in wild type (wt) mice and this induced a significant increase in myocardial Lcn2. We then compared wt and Lcn2 knockout (KO) mice and observed that wt mice showed greater ischemia-induced caspase-3 activation and DNA damage measured by TUNEL than Lcn2KO mice...
November 1, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27777988/investigation-of-helium-at-a-y2ti2o7-nanocluster-embedded-in-a-bcc-fe-matrix
#7
Thomas Danielson, Eric Tea, Celine Hin
Nanostructured ferritic alloys (NFAs) are prime candidates for structural and first wall components of fission and fusion reactors. The main reason for this is their ability to effectively withstand high concentrations of the transmutation product helium. A high number density of oxide nanoclusters dispersed throughout a BCC Fe matrix act as trapping sites for helium and prevent its eventual delivery to high risk nucleation sites. The current study uses density functional theory to investigate the helium trapping mechanisms at the boundary between BCC iron and Y2Ti2O7, a common stoichiometry of the oxide nanoclusters in NFAs...
October 25, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27767349/a-patient-centered-radiology-quality-process-map-opportunities-and-solutions
#8
Hani M Abujudeh, Adam Danielson, Michael A Bruno
OBJECTIVE: The purpose of this article is to review the tools and opportunities available for patient-centered care in radiology and to create a quality patient-centered care process map to organize them for radiology practices. CONCLUSION: This article provides a review of the many opportunities to increase and improve patient-centered care in radiology. A process map that organizes and highlights key elements of patient-centered care throughout the radiology care process is provided that can be implemented to enhance the patient experience of our services and improve the quality of care provided...
November 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27728760/surface-glycoproteins-of-exosomes-shed-by-myeloid-derived-suppressor-cells-contribute-to-function
#9
Sitara Chauhan, Steven Danielson, Virginia Clements, Nathan J Edwards, Suzanne Ostrand-Rosenberg, Catherine Fenselau
In this report we use a proteomic strategy to identify glycoproteins on the surface of exosomes derived from myeloid-derived suppressor cells (MDSC), and then test if selected glycoproteins contribute to exosome-mediated chemotaxis and migration of MDSC. We report successful modification of a surface chemistry method for use with exosomes, and identify twenty-one surface N-glycoproteins on exosomes released by mouse mammary carcinoma-induced MDSC. These glycoprotein identities and functionalities are compared with ninty-three N-linked glycoproteins identified on the surface of the parental cells...
October 11, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27721863/long-term-results-after-surgical-treatment-of-ebstein-s-anomaly-a-30-year-experience
#10
Min-Seok Kim, Hong-Gook Lim, Woong Han Kim, Jeong Ryul Lee, Yong Jin Kim
BACKGROUND AND OBJECTIVES: The aim of the study is to evaluate the long-term results after a surgical repair of Ebstein's anomaly. SUBJECTS AND METHODS: Forty-eight patients with Ebstein's anomaly who underwent open heart surgery between 1982 and 2013 were included. Median age at operation was 5.6 years (1 day-42.1 years). Forty-five patients (93.7%) demonstrated tricuspid valve (TV) regurgitation of less than moderate degree. When the patients were divided according to Carpentier's classification, types A, B, C, and D were 11, 21, 12, and 4 patients, respectively...
September 2016: Korean Circulation Journal
https://www.readbyqxmd.com/read/27689620/cellular-analysis-of-silencing-the%C3%A2-huntington-s-disease-gene-using-aav9%C3%A2-mediated-delivery-of-artificial-micro%C3%A2-rna-into-the-striatum-of%C3%A2-q140-q140%C3%A2-mice
#11
Allison M Keeler, Ellen Sapp, Kathryn Chase, Emily Sottosanti, Eric Danielson, Edith Pfister, Lorelei Stoica, Marian DiFiglia, Neil Aronin, Miguel Sena-Esteves
BACKGROUND: The genetic mutation in Huntington's disease (HD) is a CAG repeat expansion in the coding region of the huntingtin (Htt) gene. RNAi strategies have proven effective in substantially down-regulating Htt mRNA in the striatum through delivery of siRNAs or viral vectors based on whole tissue assays, but the extent of htt mRNA lowering in individual neurons is unknown. OBJECTIVE: Here we characterize the effect of an AAV9-GFP-miRHtt vector on Htt mRNA levels in striatal neurons of Q140/Q140 knock-in mice...
October 1, 2016: Journal of Huntington's Disease
https://www.readbyqxmd.com/read/27685611/efficacy-of-teaching-the-gambee-suture-pattern-using-simulated-small-intestine-versus-cadaveric-small-intestine
#12
Stephanie S Caston, Jennifer A Schleining, Jared A Danielson, Kevin D Kersh, Eric L Reinertson
OBJECTIVE: To determine if instruction using simulated small intestine (SSI) is as effective as using cadaveric small intestine to teach the Gambee suture pattern to second year veterinary students. STUDY DESIGN: Prospective, randomized, blinded study. SAMPLE POPULATION: Second year veterinary students (n=59). METHODS: Students were randomly assigned to groups using SSI or equine cadaver small intestine (CSI) to learn the Gambee suture pattern...
September 29, 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27681617/mutant-pfn1-causes-als-phenotypes-and-progressive-motor-neuron-degeneration-in-mice-by-a-gain-of-toxicity
#13
Chunxing Yang, Eric W Danielson, Tao Qiao, Jake Metterville, Robert H Brown, John E Landers, Zuoshang Xu
Mutations in the profilin 1 (PFN1) gene cause amyotrophic lateral sclerosis (ALS), a neurodegenerative disease caused by the loss of motor neurons leading to paralysis and eventually death. PFN1 is a small actin-binding protein that promotes formin-based actin polymerization and regulates numerous cellular functions, but how the mutations in PFN1 cause ALS is unclear. To investigate this problem, we have generated transgenic mice expressing either the ALS-associated mutant (C71G) or wild-type protein. Here, we report that mice expressing the mutant, but not the wild-type, protein had relentless progression of motor neuron loss with concomitant progressive muscle weakness ending in paralysis and death...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27681419/microrna-mediated-downregulation-of-the-potassium-channel-kv4-2-contributes-to-seizure-onset
#14
Christina Gross, Xiaodi Yao, Tobias Engel, Durgesh Tiwari, Lei Xing, Shane Rowley, Scott W Danielson, Kristen T Thomas, Eva M Jimenez-Mateos, Lindsay M Schroeder, Raymund Y K Pun, Steve C Danzer, David C Henshall, Gary J Bassell
Seizures are bursts of excessive synchronized neuronal activity, suggesting that mechanisms controlling brain excitability are compromised. The voltage-gated potassium channel Kv4.2, a major mediator of hyperpolarizing A-type currents in the brain, is a crucial regulator of neuronal excitability. Kv4.2 expression levels are reduced following seizures and in epilepsy, but the underlying mechanisms remain unclear. Here, we report that Kv4.2 mRNA is recruited to the RNA-induced silencing complex shortly after status epilepticus in mice and after kainic acid treatment of hippocampal neurons, coincident with reduction of Kv4...
September 27, 2016: Cell Reports
https://www.readbyqxmd.com/read/27674893/palliative-whole-brain-radiation-therapy-predictors-of-prescribing-5-versus-10-fractions
#15
S Baker, A Duimering, K Paulson, B J Debenham, S Ghosh, D L Ma, F Huang, K P M Chu, D M Severin, J O Amanie, T Nijjar, S I Patel, B Danielson, E M Wiebe, B LeGuerrier, A M Fairchild
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27667843/an-elective-course-to-train-student-pharmacists-to-deliver-a-community-based-group-diabetes-prevention-program
#16
Lisa J Woodard, Skye McKennon, Jennifer Danielson, Judy Knuth, Peggy Odegard
Objective. To develop and assess the impact of an elective course aimed at improving student knowledge of and confidence in delivering a group diabetes prevention program. Design. Two colleges of pharmacy collaborated to develop a 2-credit elective course using didactic and active-learning strategies to prepare students to serve as lifestyle coaches offering a proven group diabetes prevention program. Assessment. Students' confidence in their ability to deliver a group diabetes prevention program increased as a result of the class...
August 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/27651850/the-shift-in-existential-life-situations-of-adult-children-to-parents-with-dementia-relocated-to-nursing-homes
#17
Linda Høgsnes, Karl-Gustaf Norbergh, Ella Danielson, Christina Melin-Johansson
BACKGROUND: Previous research describes spouses and adult children of people with dementia as a homogeneous group using one term: family caregivers. Recent research shows that the needs and experiences of spouses and adult children differ, therefore they cannot be studied as a homogeneous group. AIMS: The aim of the study was to describe the shift in existential life situations of adult children of a parent with dementia relocated to nursing homes. DESIGN: This is a qualitative study with an interpretive approach...
2016: Open Nursing Journal
https://www.readbyqxmd.com/read/27624565/a-closer-look-at-non-accidental-trauma-caregiver-assault-compared-to-non-caregiver-assault
#18
Cristen N Litz, David J Ciesla, Paul D Danielson, Nicole M Chandler
PURPOSE: The purpose of this study was to examine the outcomes of non-accidental trauma (NAT) patients compared to other trauma (OT) patients across the state of Florida. In addition, NAT and OT patients with a mechanism of injury of assault were further analyzed. METHODS: A statewide database was reviewed from January 2010 to December 2014 for patients aged 0-18years who presented following trauma. Patients were sorted by admitting diagnosis into two groups: rule out NAT and all other diagnoses...
September 2, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27619009/associations-among-impulsivity-trauma-history-and-alcohol-misuse-within-a-young-adult-sample
#19
Kaitlin Bountress, Zachary W Adams, Amanda K Gilmore, Ananda B Amstadter, Suzanne Thomas, Carla K Danielson
OBJECTIVE: Young adult alcohol misuse is associated with numerous long-term adverse outcomes. Given the link between impulsivity and alcohol use, we examined whether three impulsivity-related traits differentially predicted number of drinks per drinking day (DDD). We also examined whether these effects varied for those with different trauma histories. METHOD: The current study (n=254) examined motor, non-planning, and attentional impulsivity as predictors of DDD...
August 26, 2016: Addictive Behaviors
https://www.readbyqxmd.com/read/27598423/strategic-verbal-rehearsal-in-adolescents-with-mild-intellectual-disabilities-a-multi-centre-european-study
#20
Sebastian Poloczek, Lucy A Henry, Henrik Danielson, Gerhard Büttner, Claudia Mähler, David J Messer, Kirsten Schuchardt, Mariët J van der Molen
BACKGROUND: There is a long-held view that verbal short-term memory problems of individuals with intellectual disabilities (ID) might be due to a deficit in verbal rehearsal. However, the evidence is inconclusive and word length effects as indicator of rehearsal have been criticised. AIM & METHOD: The aim of this multi-site European study was to investigate verbal rehearsal in adolescents with mild ID (n=90) and a comparison group of typically developing children matched individually for mental age (MA, n=90)...
November 2016: Research in Developmental Disabilities
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