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https://www.readbyqxmd.com/read/28328236/treated-prevalence-of-attention-deficit-hyperactivity-disorder-increased-from-2009-to-2015-among-school-aged-children-and-adolescents-in-the-united-states
#1
Kwame A Nyarko, Scott D Grosse, Melissa L Danielson, Joseph R Holbrook, Susanna N Visser, Stuart K Shapira
OBJECTIVES: The purpose of this brief is to describe changes in the treated prevalence of medically managed attention-deficit/hyperactivity disorder (ADHD) among insured school-aged children and adolescents in the United States from 2009 to 2015. We examine the differences between those with employer-sponsored insurance (ESI) and with Medicaid insurance. METHODS: We utilized two large longitudinal administrative datasets containing medical and drug claims data on individuals with ESI and Medicaid insurance from Truven Health MarketScan(®) Administrative Claims Databases...
March 22, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28324031/sex-steroid-hormones-and-fracture-in-a-multi-ethnic-cohort-of-women-the-women-s-health-initiative-study-whi
#2
Jane A Cauley, Michelle E Danielson, Guru Rajesh Jammy, Doug C Bauer, Rebecca Jackson, Jean Wactawski-Wende, Rowan T Chlebowski, Kristine E Ensrud, Robert Boudreau
CONTEXT: We hypothesize that endogenous sex steroids are associated with fracture risk independent of race/ethnicity. DESIGN AND SETTING: We performed a nested case-control study within the prospective Women's Health Initiative Observational Study (WHI-OS). Incident non-spine fractures were identified in 381 Black, 192 Hispanic, 112 Asian, and 46 Native American women over an average of 8.6 years. A random sample of 400 White women who experienced an incident fracture was chosen...
January 25, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28301610/the-effects-of-substance-p-and-acetylcholine-on-human-tenocyte-proliferation-converge-mechanistically-via-tgf-%C3%AE-1
#3
Gloria Fong, Ludvig J Backman, Håkan Alfredson, Alex Scott, Patrik Danielson
Previous in vitro studies on human tendon cells (tenocytes) have demonstrated that the exogenous administration of substance P (SP) and acetylcholine (ACh) independently result in tenocyte proliferation, which is a prominent feature of tendinosis. Interestingly, the possible link between SP and ACh has not yet been explored in human tenocytes. Recent studies in other cell types demonstrate that both SP and ACh independently upregulate TGF-β1 expression via their respective receptors, the neurokinin 1 receptor (NK-1R) and muscarinic ACh receptors (mAChRs)...
2017: PloS One
https://www.readbyqxmd.com/read/28276172/ascorbic-acid-promotes-the-stemness-of-corneal-epithelial-stem-progenitor-cells-and-accelerates-epithelial-wound-healing-in-the-cornea
#4
Jialin Chen, Jie Lan, Dongle Liu, Ludvig J Backman, Wei Zhang, Qingjun Zhou, Patrik Danielson
High concentration of ascorbic acid (vitamin C) has been found in corneal epithelium of various species. However, the specific functions and mechanisms of ascorbic acid in the repair of corneal epithelium are not clear. In this study, it was found that ascorbic acid accelerates corneal epithelial wound healing in vivo in mouse. In addition, ascorbic acid enhanced the stemness of cultured mouse corneal epithelial stem/progenitor cells (TKE2) in vitro, as shown by elevated clone formation ability and increased expression of stemness markers (especially p63 and SOX2)...
March 9, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28273530/kinetic-sorption-of-contaminants-of-emerging-concern-by-a-palygorskite-montmorillonite-filter-medium
#5
Tedros M Berhane, Jonathan Levy, Mark P S Krekeler, Neil D Danielson
Kinetic sorption of bisphenol A (BPA), carbamazepine (CMZ) and ciprofloxacin (CIP) by three palygorskite-montmorillonite (Pal-Mt) granule sizes was studied. For BPA, CMZ and CIP, apparent sorption equilibrium was reached within about 3, 5 and 16 h, respectively. The highest and the lowest sorption capacities were by the small and the large granule sizes, respectively. Experimental results were compared to various sorption kinetics models to gain insights regarding the sorption processes and achieve a predictive capacity...
February 17, 2017: Chemosphere
https://www.readbyqxmd.com/read/28258718/micellar-liquid-chromatography-of-terephthalic-acid-impurities
#6
Ashley E Richardson, Shakeela D McPherson, Jennifer M Fasciano, Richard E Pauls, Neil D Danielson
The production of terephthalic acid (TPA) by oxidation of p-xylene is an important industrial process because high purity TPA is required for the synthesis of polyethylene terephthalate, the primary polymer used to make plastic beverage bottles. Few separation methods have been published that aim to separate TPA from eight major aromatic acid impurities. This work describes a "green" micellar liquid chromatography (MLC) method using a C18 column (100×2.1mm, 3.5μm), an acidic 1% sodium dodecyl sulfate (SDS) mobile phase, and a simple step flow rate gradient to separate TPA and eight impurities in less than 20min...
March 31, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28256053/making-inroads-to-the-cure-barriers-to-clinical-trial-enrollment-in-hematopoietic-cell-transplantation
#7
REVIEW
Michael Byrne, Nathalie Danielson, Amanda Harris, Bipin N Savani
A significant barrier to advancing the standard of care for patients with hematologic malignancies undergoing stem cell transplantation is access and willingness to participate in clinical trials. The importance of clinical trial enrollment is magnified in an era of targeted therapies, accelerated drug discovery, and investment by the pharmaceutical industry. As disease targets are identified, novel therapies are being evaluated in efforts to reduce treatment-related toxicity and improve progression-free and overall survival...
March 3, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28254245/design-of-a-multisite-study-assessing-the-impact-of-tic-disorders-on-individuals-families-and-communities
#8
E F Augustine, H R Adams, R H Bitsko, E van Wijngaarden, A H Claussen, A Thatcher, C E Hanks, A B Lewin, T G O'Connor, A Vierhile, M L Danielson, R Kurlan, T K Murphy, J W Mink
BACKGROUND: Tic disorders, including Tourette syndrome, are complex, multisymptom diseases, yet the impact of these disorders on affected children, families, and communities is not well understood. METHODS: To improve the understanding of the impacts of Tourette syndrome, two research groups conducted independent cross-sectional studies using qualitative and quantitative measures. They focused on similar themes, but distinct scientific objectives, and the sites collaborated to align methods of independent research proposals with the aim of increasing the analyzable sample size...
March 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28248246/let-there-be-light
#9
REVIEW
Doroteya Raykova, Björn Koos, Anna Asplund, Márton Gelléri, Ylva Ivarsson, U Helena Danielson, Ola Söderberg
The invention of the microscope has been fundamental for the understanding of tissue architecture and subcellular structures. With the advancement of higher magnification microscopes came the development of various molecular biology tools such as Förster resonance energy transfer (FRET) and in situ proximity ligation assay (in situ PLA) to monitor protein interactions. Microscopy has become a commonly used method for the investigation of molecular events within the cell, for the identification of key players in signaling networks, and the activation of these pathways...
November 29, 2016: Proteomes
https://www.readbyqxmd.com/read/28225647/early-experience-with-single-incision-laparoscopic-total-abdominal-colectomy-in-children
#10
Cristen N Litz, Paul D Danielson, Nicole M Chandler
PURPOSE: Single-incision laparoscopic surgery for pediatric colorectal disease has been shown to be feasible and safe; however, the literature is scarce regarding the outcomes of single-incision laparoscopic total abdominal colectomy (SIL-TAC) in the pediatric population. The purpose of this pilot study was to review our initial experience and outcomes with SIL-TAC. MATERIALS AND METHODS: A retrospective review of patients who underwent SIL-TAC from 2013 to 2015 was performed...
February 22, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28183786/extracellular-rnas-are-associated-with-insulin-resistance-and-metabolic-phenotypes
#11
Ravi Shah, Venkatesh Murthy, Michael Pacold, Kirsty Danielson, Kahraman Tanriverdi, Martin G Larson, Kristina Hanspers, Alexander Pico, Eric Mick, Jared Reis, Sarah de Ferranti, Elizaveta Freinkman, Daniel Levy, Udo Hoffmann, Stavroula Osganian, Saumya Das, Jane E Freedman
OBJECTIVE: Insulin resistance (IR) is a hallmark of obesity and metabolic disease. Circulating extracellular RNAs (ex-RNAs), stable RNA molecules in plasma, may play a role in IR, though most studies on ex-RNAs in IR are small. We sought to characterize the relationship between ex-RNAs and metabolic phenotypes in a large community-based human cohort. RESEARCH DESIGN AND METHODS: We measured circulating plasma ex-RNAs in 2,317 participants without diabetes in the Framingham Heart Study (FHS) Offspring Cohort at cycle 8 and defined associations between ex-RNAs and IR (measured by circulating insulin level)...
February 9, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28182899/dentate-mossy-cell-and-pattern-separation
#12
Kazu Nakazawa
Three studies by Danielson et al. (2017), GoodSmith et al. (2017), and Sensai and Buzsáki (2017) distinguish in vivo firing properties of dentate mossy cells from granule cells during behavior. Robust spatial remapping of mossy cells, in contrast to sparse firing of granule cells, suggests differential involvement in pattern separation.
February 8, 2017: Neuron
https://www.readbyqxmd.com/read/28179169/vertebral-bone-marrow-fat-bone-mineral-density-and-diabetes-the-osteoporotic-fractures-in-men-mros-study
#13
Yahtyng Sheu, Francesca Amati, Ann V Schwartz, Michelle E Danielson, Xiaojuan Li, Robert Boudreau, Jane A Cauley
Elevated vertebral bone marrow fat (BMF) among individuals with osteoporosis has been established in histomorphometric studies. Several studies have found a negative correlation between BMF and bone mineral density (BMD) at the spine in men and women across different age groups. Animal studies have also observed bone loss with increased BMF in mice with induced diabetes. Our study objective was to test the hypothesis that the association between BMF and BMD varies by diabetic status. We performed a cross-sectional study of 156 men aged 74-96years from the Osteoporotic Fractures in Men study at the Pittsburgh clinical site...
February 4, 2017: Bone
https://www.readbyqxmd.com/read/28163364/distress-tolerance-and-social-support-in-adolescence-predicting-risk-for-internalizing-and-externalizing-symptoms-following-a-natural-disaster
#14
Joseph R Cohen, Carla Kmett Danielson, Zachary W Adams, Kenneth J Ruggiero
The purpose of the multi-measure, multi-wave, longitudinal study was to examine the interactive relation between behavioral distress tolerance (DT) and perceived social support (PSS) in 352 tornado-exposed adolescents aged 12-17 years (M=14.44; SD=1.74). At baseline, adolescents completed a computer-based task for DT, and self-report measures of PSS, depressed mood, posttraumatic stress disorder (PTSD), substance use, and interpersonal conflict. Symptoms also were assessed 4 and 12 months after baseline. Findings showed that lower levels of DT together with lower levels of PSS conferred risk for elevated symptoms of prospective depression (t(262)= -2...
December 2016: Journal of Psychopathology and Behavioral Assessment
https://www.readbyqxmd.com/read/28156673/palliative-whole-brain-radiotherapy-predictors-of-prescribing-5-versus-10-fractions
#15
Sarah Baker, Kim Paulson, Brock J Debenham, Sunita Ghosh, David L Ma, Fleur Huang, Karen P Chu, Diane Severin, John Amanie, Tirath Nijjar, Samir Patel, Ericka Wiebe, Brita Lavender Danielson, Bronwen LeGuerrier, Alysa M Fairchild
219 Background: The optimal dose for palliative whole brain radiotherapy (WBRT) continues to be debated. Common regimens include 20 Gy in five and 30 Gy in 10 fractions. We aimed to identify factors associated with WBRT dose schedules, hypothesizing that clinical prediction of survival (CPS) would influence prescribing practice. METHODS: Demographic and clinicopathologic data were collected for consecutive patients with brain metastases receiving WBRT through a dedicated palliative radiation oncology clinic...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156672/attitude-and-support-to-inform-clinical-predictions-of-survival-in-patients-with-advanced-cancer
#16
David L Ma, Kim Paulson, Sunita Ghosh, Bronwen LeGuerrier, Karen P Chu, Diane Severin, Fleur Huang, Sharon Watanabe, Ann Huot, John Amanie, Samir Patel, Tirath Nijjar, Ericka Wiebe, Brita Lavender Danielson, Brock J Debenham
39 Background: Tumour factors (eg primary site, size) helpful in prognostication in early stage cancer may be less important than patient factors, such as Karnofsky performance status (KPS), later in the disease trajectory. We evaluated the utilization of the parameters attitude (ATT) and psychosocial support (PSS) in predicting remaining lifespan by two experienced multidisciplinary teams (MDT). METHODS: After clinical assessment of consecutive patients, a quantitative clinical prediction of survival (CPS) was made prospectively, independently and anonymously by each health care provider (HCP)...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156489/the-evolving-radiation-therapist-role-in-a-multidisciplinary-palliative-radiotherapy-clinic
#17
Fleur Huang, Winter Spence, Brenda Rose, Jacqueline Middleton, Megan Palen, Kitta Thavone, Shazma Ravji, Brita Lavender Danielson, Alysa M Fairchild
158 Background: Radiation therapists (MRTT) have been integrated in varying capacities into outpatient palliative radiotherapy (PRT) services across Canada for nearly two decades. We explored the experience of our centre's MRTTs who have developed an essential role over nine years, from supporting one half-day PRT clinic per week to five full days of clinical, technical, research, and administrative involvement. METHODS: An electronic survey was distributed to all 12 MRTTs who contributed to the PRT program (2007-2016), which was later supplemented by in-person semi-structured interviews...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28132825/in%C3%A2-vivo-imaging-of-dentate-gyrus-mossy-cells-in-behaving-mice
#18
Nathan B Danielson, Gergely F Turi, Max Ladow, Spyridon Chavlis, Panagiotis C Petrantonakis, Panayiota Poirazi, Attila Losonczy
Mossy cells in the hilus of the dentate gyrus constitute a major excitatory principal cell type in the mammalian hippocampus; however, it remains unknown how these cells behave in vivo. Here, we have used two-photon Ca(2+) imaging to monitor the activity of mossy cells in awake, behaving mice. We find that mossy cells are significantly more active than dentate granule cells in vivo, exhibit spatial tuning during head-fixed spatial navigation, and undergo robust remapping of their spatial representations in response to contextual manipulation...
February 8, 2017: Neuron
https://www.readbyqxmd.com/read/28126364/the-association-between-diabetes-status-and-survival-following-an-out-of-hospital-cardiac-arrest-a-retrospective-cohort-study
#19
Monica Parry, Kyle Danielson, Sarah Brennenstuhl, Ian R Drennan, Laurie J Morrison
BACKGROUND: Sudden cardiac arrest (SCA), confirmed absence of cardiac mechanical activity, is the leading cause of heart-related death in the US. Almost 85% of SCA occur out-of-hospital (OHCA), with very poor rates of return of spontaneous circulation (ROSC) and survival to hospital discharge. We sought to determine if diabetes status was associated with survival or ROSC following an OHCA. METHODS: We completed a retrospective cohort study using data from the Toronto Regional RescuNet Epistry dataset, based upon data definitions defined by the Resuscitation Outcomes Consortium (ROC) Epistry-Cardiac Arrest and the Strategies for Post Arrest Resuscitation Care (SPARC) network datasets...
January 23, 2017: Resuscitation
https://www.readbyqxmd.com/read/28060806/high-throughput-sequencing-of-extracellular-rna-from-human-plasma
#20
Kirsty M Danielson, Renee Rubio, Fieda Abderazzaq, Saumya Das, Yaoyu E Wang
The presence and relative stability of extracellular RNAs (exRNAs) in biofluids has led to an emerging recognition of their promise as 'liquid biopsies' for diseases. Most prior studies on discovery of exRNAs as disease-specific biomarkers have focused on microRNAs (miRNAs) using technologies such as qRT-PCR and microarrays. The recent application of next-generation sequencing to discovery of exRNA biomarkers has revealed the presence of potential novel miRNAs as well as other RNA species such as tRNAs, snoRNAs, piRNAs and lncRNAs in biofluids...
2017: PloS One
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