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11C Acetate

Claudio Spick, Ken Herrmann, Johannes Czernin
In this article, we will first describe the metabolic fate of (11)C-acetate; then discuss its biodistribution in health and disease; and subsequently focus on its key clinical applications, the detection and localization of prostate cancer tissue in patients with primary or recurrent disease. Finally, we will discuss the potential role of (11)C-acetate in the context of other prostate cancer imaging probes and non-radionuclide-based imaging approaches.
October 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Varut Vardhanabhuti, Anthony W I Lo, Elaine Y P Lee, Simon Y K Law
Dual-tracer F-FDG and C-acetate PET/CT has been shown to demonstrate good sensitivity and specificity for the diagnosis of hepatocellular carcinoma. We present a case of gastric adenocarcinoma with liver metastasis with positive uptake of F-FDG and C-acetate highlighting an unusual appearance in dual-tracer PET/CT.
November 2016: Clinical Nuclear Medicine
Junzhong Liu, Zhongfeng Chen, Tianyu Wang, Li Liu, Lei Zhao, Guangtao Guo, Dongqing Wang
BACKGROUND/AIMS: To date, several positron emission tomography/computed tomography (PET/CT) radiotracers including fluorine-18 fluorodeoxyglucose (18F-FDG), carbon-11 labeled choline (11C-choline), 18-F fluorocholine (18F-FCH) and carbon-11 acetate (11C-acetate) have already been assessed in the application of prostate cancer (PCa) diagnosis to some extent, the diagnostic efficiency of these radiotracers still remain controversial. As a result of this, we carried out this meta-analysis for the purpose of comparing the diagnostic accuracy among four PET/CT radiotracers...
2016: Cellular Physiology and Biochemistry
Antti P Salminen, Ivan Jambor, Kari T Syvanen, Peter J Bostrom
Staging of muscle-invasive bladder cancer (MIBC) remains a challenge. It is generally acknowledged that the most commonly used imaging techniques have a trend to either upstage or downstage the disease. The aim of this review article is to evaluate the currently available scientific evidence for the use of imaging modalities in preoperative bladder cancer staging with special attention to the detection of lymph node metastasis (LNM). A non-systematic literature search utilizing PubMed database with terms MIBC and LN and MRI or PET or CT was performed with the search limited to articles published between 2010 and 2015...
April 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
Hossein Jadvar
Prostate cancer is a prevalent public health problem worldwide. While imaging has played a major role in this disease, there still remain many challenges and opportunities. Positron emission tomography with various physiologically based radiotracers is fundamentally suited to interrogate this biologically and clinically heterogeneous disease along the course of its natural history. In this article, I review briefly the published evidence for the use of positron emission tomography with 18F-fluorodeoxyglucose, 11C-acetate, and 18F- or 11C-choline in the imaging evaluation of prostate cancer...
May 2016: Abdominal Radiology
Sébastien M Labbé, Alexandre Caron, Kanta Chechi, Mathieu Laplante, Roger Lecomte, Denis Richard
Classical brown adipocytes such as those found in interscapular brown adipose tissue (iBAT) represent energy-burning cells, which have been postulated to play a pivotal role in energy metabolism. Brown adipocytes can also be found in white adipose tissue (WAT) depots [e.g., inguinal WAT (iWAT)] following adrenergic stimulation, and they have been referred to as "beige" adipocytes. Whether the presence of these adipocytes, which gives iWAT a beige appearance, can confer a white depot with some thermogenic activity remains to be seen...
July 1, 2016: American Journal of Physiology. Endocrinology and Metabolism
Wenjia Zhu, Yonghong Dang, Yanru Ma, Fang Li, Li Huo
A 67-year-old man with newly diagnosed multiple myeloma underwent both FDG and C-acetate PET/CT sequentially on different days. There was increased FDG activity only in L1 vertebral body, but there was diffuse abnormal C-acetate activity throughout the skeletal system. After the successful therapy, the patient who was on remission clinically underwent follow-up PET/CT scans. Interestingly, L1 remained to have elevated FDG, although with less intensity. In contrast, there was no abnormal C-acetate activity anywhere in the body...
July 2016: Clinical Nuclear Medicine
Anthony Pak-Yin Liu, Ka-Nin Wong, Queenie Wing-Shan See, Godfrey Chi-Fung Chan, Alan Kwok-Shing Chiang
Hepatoblastoma is the most common primary liver cancer in the pediatric population. Disease relapse might be occult and difficult to detect. C-acetate positron emission tomography has been applied in patients with hepatocellular carcinoma due to the insensitivity of fluorodeoxyglucose, but data on hepatoblastoma patients have been scarce. We describe the use of C-acetate positron emission tomography/computed tomography scan as a sensitive method in the identification of an occult bony metastatic recurrence in a 6-year-old girl with a history of hepatoblastoma treated with chemotherapy...
May 2016: Journal of Pediatric Hematology/oncology
Guilan Hu, Yanru Ma, Yonghong Dang, Fang Li, Li Huo
A 70-year-old man was incidentally found to have an occupying lesion in the left renal pelvis by ultrasonography during a routine health examination. CT images suggested renal cell carcinoma. FDG PET/CT scan was acquired for staging. The images did not reveal any hypermetabolic metastases. However, the metabolic activity of the lesion in the right renal pelvis was not unambiguously determined because of interference of radioactive urine. C-acetate PET/CT, on the other hand, clearly revealed increased activity in the left renal pelvis...
May 2016: Clinical Nuclear Medicine
Dan Liu, Pek-Lan Khong, Yiming Gao, Usman Mahmood, Brian Quinn, Jean St Germain, X George Xu, Lawrence T Dauer
UNLABELLED: Combined whole-body dual-tracer ((18)F-FDG and (11)C-acetate) PET/CT is increasingly used for staging hepatocellular carcinoma, with only limited studies investigating the radiation dosimetry data of these scans. The aim of the study was to characterize the radiation dosimetry of combined whole-body dual-tracer PET/CT protocols. METHODS: Consecutive adult patients with hepatocellular carcinoma who underwent whole-body dual-tracer PET/CT scans were retrospectively reviewed with institutional review board approval...
June 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
A P Salminen, I Jambor, K T Syvänen, P J Boström
Staging of muscle invasive bladder cancer (MIBC) remains a challenge. It is generally acknowledged that the most commonly used imaging techniques have a trend either to upstage or downstage the disease. The aim of this review article is to evaluate the currently available scientific evidence for the use of imaging modalities in preoperative bladder cancer staging with special attention to detection of lymph node metastasis (LNM). A non-systematic literature search utilizing PUBMED database with terms MIBC and LN and MRI or PET or CT was performed with the search limited to articles published between 2010-2015...
December 18, 2015: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
Claudio Spick, Stephan H Polanec, Markus Mitterhauser, Wolfgang Wadsak, Philip Anner, Bettina Reiterits, Alexander R Haug, Marcus Hacker, Mohsen Beheshti, Georgios Karanikas
AIM: To evaluate the diagnostic accuracy of (11)C-acetate positron-emission tomography (PET) in the detection of bone metastasis in patients with prostate cancer with biochemical recurrence. PATIENTS AND METHODS: Ninety patients (100%) with rising prostate-specific antigen (PSA) levels (>0.2 ng/ml) after radical prostatectomy, who had both (11)C-acetate PET and bone scan performed and who had clinical follow-up/imaging follow-up for bone metastasis, considered a gold standard, were included...
December 2015: Anticancer Research
Qiaohong Ouyang, Zhongxiang Duan, Jixiao Lei, Guangli Jiao
The early diagnosis of prostate cancer (PCa) appears to be of vital significance for the provision of appropriate treatment programs. Even though several sophisticated imaging techniques such as positron emission tomography/computed tomography (PET/CT) and elastosonography (ES) have already been developed for PCa diagnosis, the diagnostic accuracy of these imaging techniques is still controversial to some extent. Therefore, a comprehensive meta-analysis in this study was performed to compare the accuracy of various diagnostic imaging methods for PCa, including 11C-choline PET/CT, 11C-acetate PET/CT, 18F-fluorocholine PET/CT, 18F-fluoroglucose PET/CT, transrectal real-time elastosonography (TRTE), and shear-wave elastosonography (SWE)...
March 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
E Bombardieri, L Setti, M Kirienko, L Antunovic, P Guglielmo, G Ciocia
Prostate cancer bone metastases occur frequently in advanced cancer and this is matter of particular attention, due to the great impact on patient's management and considering that a lot of new emerging therapeutic options have been recently introduced. Imaging bone metastases is essential to localize lesions, to establish their size and number, to study characteristics and changes during therapy. Besides radiological imaging, nuclear medicine modalities can image their features and offer additional information about their metabolic behaviour...
December 2015: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Clare Beadsmoore, David Newman, Duncan MacIver, Davina Pawaroo
Cancer remains a leading cause of death in Canada and worldwide. Whilst advances in anatomical imaging to detect and monitor malignant disease have continued over the last few decades, limitations remain. Functional imaging, such as positron emission tomography (PET), has improved the sensitivity and specificity in detecting malignant disease. In combination with computed tomography (CT), PET is now commonly used in the oncology setting and is an integral part of many cancer patients' pathways. Although initially the CT component of the study was purely for attenuation of the PET imaging and to provide anatomical coregistration, many centers now combine the PET study with a diagnostic quality contrast enhanced CT to provide one stop staging, thus refining the patient's pathway...
November 2015: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
M Jermoumi, E Sajo, K Houari, W Ngwa
PURPOSE: Studies have shown that radiation boosting could help reduce prostate cancer (PCa) recurrence. Biological tumor volumes (BTV) are a high priority for such radiation boosting. The purpose of this study is to investigate the potential of radiation boosting of real patient BTVs using gold nanoparticles (GNP) released from gold-loaded brachytherapy spacers (GBS) during brachytherapy. METHODS: The BTVs of 12 patients having prostate adenocarcinoma identified with positron emission tomography (PET) and CT scanner using C-11 labeled tracer [11C]acetate were investigated...
June 2015: Medical Physics
F Fernandes, D da Silva, L Rodrigues
PURPOSE: The aim of this work was to review new and clinical practice PET radiopharmaceuticals for prostate cancer imaging. METHODS: PET radiopharmaceuticals were reviewed on the main databases. Availability, dosimetry, accuracy and limitations were considered. RESULTS: The following radioisotopes with respective physical half-life and mean positron energy were found: (18)F (109,7 min, 249,8 keV), (89)Zr (78,4 hs, 395,5 keV), (11)C (20,4 min, 385,7 keV) and (68)Ga (67,8 min, 836 keV)...
June 2015: Medical Physics
Veer A Shah, Allison Rixey, Reginald Dusing
The inguinal lymph nodes are an unusual site of metastases for prostate adenocarcinoma. We present a case in which a 61-y-old man with biochemically recurrent prostate cancer underwent attenuation-corrected (11)C-acetate PET/CT, which demonstrated multiple foci of increased activity in the left inguinal, left iliac chain, and right inguinal regions. The attenuation-corrected CT portion of the scan also showed anterior wall thickening of the rectum. The imaging findings were suggestive of metastatic involvement of the rectum below the dentate line with subsequent spread to the inguinal lymph nodes...
March 2016: Journal of Nuclear Medicine Technology
Georgios Daouacher, Catrin von Below, Charlotta Gestblom, Håkan Ahlström, Rafael Grzegorek, Cecilia Wassberg, Jens Sörensen, Mauritz Waldén
OBJECTIVES: To evaluate the accuracy of the radiopharmaceutical [(11) C]-acetate combined with positron emission tomography/computer tomography (acetate-PET/CT) in lymph node (LN) staging in newly diagnosed prostate cancer cases. A second aim was to evaluate the potential discriminative properties of acetate-PET/CT in clinical routine. PATIENTS AND METHODS: In a prospective comparative study, from July 2010 to June 2013, 53 men with newly histologically diagnosed intermediate- or high-risk prostate cancer underwent acetate-PET/CT investigation at one regional centre before laparoscopic extended pelvic LN dissection (ePLND) at one referral centre...
July 2016: BJU International
Chee-Kin Hui
Tuberculous scar tumour is difficult to diagnose as it does not present with any respiratory symptoms and has a negative chest X-ray. This is a case report on the use of dual tracer 11C-acetate and 18F-fluorodeoxyglucose (18FDG) whole body positron emission tomography-computerised tomography (PET-CT) for detection of tuberculous scar tumour. A 44-year-old Chinese female was incidentally found to have a raised serum Ca 19.9. Magnetic resonance imaging of the whole abdomen, upper endoscopy, and colonoscopy were all unremarkable...
November 2014: Malaysian Journal of Medical Sciences: MJMS
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