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Neonatal over exposure

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https://www.readbyqxmd.com/read/29773464/sex-and-gender-differences-in-developmental-programming-of-metabolism
#1
REVIEW
Laura Dearden, Sebastien G Bouret, Susan E Ozanne
BACKGROUND: The early life environment experienced by an individual in utero and during the neonatal period is a major factor in shaping later life disease risk-including susceptibility to develop obesity, diabetes, and cardiovascular disease. The incidence of metabolic disease is different between males and females. How the early life environment may underlie these sex differences is an area of active investigation. SCOPE OF REVIEW: The purpose of this review is to summarize our current understanding of how the early life environment influences metabolic disease risk in a sex specific manner...
April 30, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29767714/comparing-postnatal-development-of-gonadal-hormones-and-associated-social-behaviors-in-rats-mice-and-humans
#2
Margaret R Bell
Postnatal development includes dramatic changes in gonadal hormones and the many social behaviors they help regulate, both in rodents and humans. Parental care-seeking is the most salient social interaction in neonates and infants, play and pro-social behaviors are commonly studied in juveniles, and the development of aggression and sexual behavior begins in peripubertal stages but continues through late adolescence into adulthood. While parental behaviors are shown after reproductive success in adulthood, alloparenting behaviors are actually high in juveniles as well...
May 14, 2018: Endocrinology
https://www.readbyqxmd.com/read/29764580/-effect-of-rhubarb-on-neonatal-rats-with-bronchopulmonary-dysplasia-induced-by-hyperoxia
#3
Ling-Ling Yin, Zhen-Zhi Ye, Li-Jun Tang, Liang Guo, Wei-Min Huang
OBJECTIVE: To study the effect of rhubarb on neonatal rats with bronchopulmonary dysplasia (BPD) induced by hyperoxia. METHODS: A total of 64 rats (postnatal day 4) were randomly divided into four groups: air control, rhubarb control, hyperoxia model, and hyperoxia+rhubarb (n=16 each). The rats in the hyperoxia model and hyperoxia+rhubarb groups were exposed to hyperoxia (60% O2) to establish a BPD model. The rats in the rhubarb control and hyperoxia+rhubarb groups were given rhubarb extract suspension (600 mg/kg) by gavage daily...
May 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29751176/il-4-mediates-the-delayed-neurobehavioral-impairments-induced-by-neonatal-hepatitis-b-vaccination-that-involves-the-down-regulation-of-the-il-4-receptor-in-the-hippocampus
#4
Xiao Wang, Junhua Yang, Zhiwei Xing, Hongyang Zhang, Yaru Wen, Fangfang Qi, Zejie Zuo, Jie Xu, Zhibin Yao
We have previously verified that neonatal hepatitis B vaccination induced hippocampal neuroinflammation and behavior impairments in mice. However, the exact mechanism of these effects remain unclear. In this study, we observed that neonatal hepatitis B vaccination induced an anti-inflammatory cytokine response lasting for 4-5 weeks in both the serum and the hippocampus, primarily indicated by elevated IL-4 levels. Three weeks after the vaccination schedule, however, hepatitis B vaccine (HBV)-mice showed delayed hippocampal neuroinflammation...
May 8, 2018: Cytokine
https://www.readbyqxmd.com/read/29706435/decreasing-urinary-organophosphate-pesticide-metabolites-among-pregnant-women-and-their-offspring-in-jerusalem-impact-of-regulatory-restrictions-on-agricultural-op-use
#5
Eliana Ein-Mor, Zivanit Ergaz-Shaltiel, Tamar Berman, Thomas Göen, Juma Natsheh, Avraham Ben-Chetrit, Ronit Haimov-Kochman, Ronit Calderon-Margalit
INTRODUCTION: Maternal urinary levels of dialkyl phosphate (DAP) metabolites of organophosphate pesticides (OP) during pregnancy are associated with adverse outcomes in the offspring. Between 2012 and 2014, eighteen active OP ingredients were restricted or banned in Israel for agricultural use. AIM: We aimed to study trends of urinary DAP metabolites among pregnant women and their offspring in the era of the new regulations. METHODS: Pregnant women were recruited at 11-18 weeks of gestation and provided spot urine samples (n = 273)...
March 31, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29680262/clinical-implications-of-intravenous-drug-incompatibilities-in-critically-ill-patients
#6
REVIEW
Malik Benlabed, Maxime Perez, Romain Gaudy, Stéphanie Genay, Damien Lannoy, Christine Barthélémy, Pascal Odou, Gilles Lebuffe, Bertrand Décaudin
OBJECTIVE: The aim of this review is to analyse the clinical consequences of intravenous drug incompatibilities in critically ill patients, especially the incidence of organ dysfunctions and mortality. METHODS: A review of literature was conducted according to the PRISMA statement in June 2017, using Medline, ISI Web of Science and Clinicaltrials.gov. DATA EXTRACTION: Eligible studies were case reports and randomised controlled trials (RCTs) that assessed the effects of drug incompatibilities in critically ill patients on morbidity or mortality as primary or secondary outcomes, or adverse events...
April 19, 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29627934/inhibition-of-microrna-23-contributes-to-the-isoflurane-mediated-cardioprotection-against-oxidative-stress
#7
Hai-Jian Liu, Bin Liu
Isoflurane is one of the most frequently used volatile anesthetics in clinical practice for inhalational anesthesia. It is widely studied that isoflurane mediates cardioprotection during multiple pathological processes. However, the precise mechanisms have not been fully elucidated. Neonatal cardiomyocytes were isolated and cultured, followed by treatments with isoflurane at 0, 50, 100 or 200 µM. Rat cardiomyoblast cell line, H9c2, was treated with H2 O2 . Expression of miR-23 was measured by qRT-PCR. The cell survival rate of H9c2 in response to H2 O2 treatments was evaluated by MTT assay...
April 7, 2018: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29615218/placental-promoter-methylation-of-dna-repair-genes-and-prenatal-exposure-to-particulate-air-pollution-an-environage-cohort-study
#8
Kristof Y Neven, Nelly D Saenen, Letitzia Tarantini, Bram G Janssen, Wouter Lefebvre, Charlotte Vanpoucke, Valentina Bollati, Tim S Nawrot
BACKGROUND: Exposure to particulate air pollution has been linked with risk of carcinogenesis. Damage to repair pathways might have long-term adverse health effects. We aimed to investigate the association of prenatal exposure to air pollution with placental mutation rate and the DNA methylation of key placental DNA repair genes. METHODS: This cohort study used data from the ongoing ENVironmental Influence ON early AGEing (ENVIRONAGE) birth cohort, which enrols pairs of mothers and neonates (singleton births only) at the East-Limburg Hospital (Genk, Belgium)...
April 2018: Lancet. Planetary Health
https://www.readbyqxmd.com/read/29614247/pseudomonas-aeruginosa-adapts-to-octenidine-in-the-laboratory-and-a-simulated-clinical-setting-leading-to-increased-tolerance-to-chlorhexidine-and-other-biocides
#9
Matthew J Shepherd, Ginny Moore, Matthew E Wand, J Mark Sutton, Lucy J Bock
BACKGROUND: Octenidine is frequently used for infection prevention in neonatal and burn intensive care units, where Pseudomonas aeruginosa has caused nosocomial outbreaks. AIM: To investigate the efficacy and impact of using octenidine against P. aeruginosa. METHODS: Seven clinical isolates of P. aeruginosa were exposed to increasing concentrations of octenidine over several days. Fitness, minimum bactericidal concentrations after 1 minute, 5 minutes and 24 hours, and minimum inhibitory concentrations of a variety of antimicrobials were measured for the parental and octenidine-adapted P...
March 31, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29601303/the-opioid-epidemic-and-pregnancy-implications-for-anesthetic-care
#10
Britany L Raymond, Bradley T Kook, Michael G Richardson
PURPOSE OF REVIEW: This review summarizes evolving knowledge regarding adverse maternal, fetal, and neonatal effects of opioid exposure during pregnancy, and current treatment options for opioid use disorder (OUD). Maternal and fetal implications of maternal opioid maintenance with methadone and buprenorphine are described. Finally, acute and chronic pain management strategies in opioid-tolerant parturients are reviewed. RECENT FINDINGS: Opioid use among parturients has risen dramatically, with opioid use during pregnancy as high as 20%...
March 29, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29584524/impact-of-neonatal-intensive-care-unit-admission-on-bacterial-colonization-of-donated-human-milk
#11
Amir Elmekkawi, Deborah L O'Connor, Debbie Stone, Eugene W Yoon, Michael Larocque, Allison McGeer, Sharon Unger
BACKGROUND: Unpasteurized human donor milk typically contains a variety of bacteria. The impact of neonatal intensive care unit (NICU) admission of the donor's infant and duration of lactation on bacterial contamination of human milk is unknown. Research aim: This study aimed (a) to describe the frequency/concentration of skin commensal bacteria and pathogens in unpasteurized human donor milk and (b) to assess the impact of NICU admission and (c) the duration of milk expression on bacterial colonization of donated milk...
March 1, 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/29554907/prenatal-and-postnatal-antibiotic-exposure-influences-the-gut-microbiota-of-preterm-infants-in-neonatal-intensive-care-units
#12
Zhi-Hui Zou, Dong Liu, Hong-Dong Li, Dan-Ping Zhu, Yu He, Ting Hou, Jia-Lin Yu
BACKGROUND: To explore the influences of prenatal antibiotic exposure, the intensity of prenatal and postnatal antibiotic exposure on gut microbiota of preterm infants and whether gut microbiota and drug resistant strains in the neonatal intensive care unit (NICU) over a defined period are related. METHODS: Among 28 preterm infants, there were two groups, the PAT (prenatal antibiotic therapy) group (12 cases), and the PAF (prenatal antibiotic free) group (12 cases)...
March 19, 2018: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/29547380/maternal-opioid-use-disorder-and-neonatal-abstinence-syndrome-in-northwest-ontario-a-7-year-retrospective-analysis
#13
Joe Dooley, Gareth Ryan, Lianne Gerber Finn, Megan Bollinger, Cai-Lei Matsumoto, Wilma M Hopman, Len Kelly
INTRODUCTION: Opioid use in pregnancy is increasing globally. In northwest Ontario, rates of neonatal abstinence syndrome (NAS) are alarmingly high. We sought to document the increasing rates of opioid exposure during pregnancy and associated cases of NAS over a 7-year period in northwest Ontario. METHODS: We conducted a retrospective chart review at the Sioux Lookout Meno Ya Win Health Centre catchment area (population 29 000) maternity program in northwest Ontario of mother-infant dyads of live births from Jan...
2018: Canadian Journal of Rural Medicine
https://www.readbyqxmd.com/read/29538366/prenatal-perinatal-and-neonatal-risk-factors-of-autism-spectrum-disorder
#14
Elizabeth Hisle-Gorman, Apryl Susi, Theophil Stokes, Gregory Gorman, Christine Erdie-Lalena, Cade M Nylund
BackgroundWe explored the association of 29 previously reported neonatal, perinatal, and prenatal conditions, and exposures with later diagnosis of autism spectrum disorder (ASD) in a large sample of children followed over multiple years.MethodsA retrospective case-cohort study was formed using the Military Health System database. Cases were identified by International Classification of Diseases, Ninth Revision codes for ASD between 2000 and 2013, and were matched 3:1 with controls on sex, date of birth, and enrollment time frame...
April 18, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29535025/intergenerational-response-to-the-endocrine-disruptor-vinclozolin-is-influenced-by-maternal-genotype-and-crossing-scheme
#15
Edward W Pietryk, Kiristin Clement, Marwa Elnagheeb, Ryan Kuster, Kayla Kilpatrick, Michael I Love, Folami Y Ideraabdullah
In utero exposure to vinclozolin (VIN), an antiandrogenic fungicide, is linked to multigenerational phenotypic and epigenetic effects. Mechanisms remain unclear. We assessed the role of antiandrogenic activity and DNA sequence context by comparing effects of VIN vs. M2 (metabolite with greater antiandrogenic activity) and wild-type C57BL/6 (B6) mice vs. mice carrying mutations at the previously reported VIN-responsive H19/Igf2 locus. First generation offspring from VIN-treated 8nrCG mutant dams exhibited increased body weight and decreased sperm ICR methylation...
March 10, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29485940/surveillance-of-intrauterine-opioid-exposures-using-electronic-health-records
#16
Eric S Hall, Scott L Wexelblatt, James M Greenberg
The objective was to use population-based electronic health records for surveillance of intrauterine exposures to substances of abuse, including opioids, and to monitor changes in exposure rates over time. This retrospective, descriptive analysis utilized geocoded neonatal physician billing records representing intrauterine exposures to substances of abuse detected through universal maternal drug testing. Census tract-level exposure rates were identified among the newborn population of Hamilton County, Ohio between 2014 and 2016...
February 27, 2018: Population Health Management
https://www.readbyqxmd.com/read/29478349/utilization-of-conventional-radiography-in-a-regional-neonatal-intensive-care-unit-in-ireland
#17
Miranda R Crealey, Louise Bowden, Evodia Ludusan, Muhammad Pathan, Brian Kenny, Ailish Hannigan, Roy K Philip
OBJECTIVE: To audit the demand and radiation exposure of conventional radiography in a regional neonatal intensive care unit (NICU) in Ireland. METHODS: A retrospective study of radiographs performed on all admissions to the NICU in University Maternity Hospital Limerick (UMHL) over 2 years. RESULTS: A total of 1405 radiographs were performed on 506 infants. 153.5 radiographs per 1000 live births was the observed demand and 44% of radiographs were done out of hours...
March 12, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29467350/influence-of-nitrous-oxide-on-granule-cell-migration-in-the-dentate-gyrus-of-the-neonatal-rat
#18
Hitoshi Saito, Rui Kato, Toshikazu Hashimoto, Yosuke Uchida, Tetsutaro Hase, Kenkichi Tsuruga, Koichi Takita, Yuji Morimoto
For several decades, the neurotoxicities of anesthetics to the developing brain have been reported by many researchers focusing on various phenomena such as apoptosis, neurodegeneration, electrophysiological aberrations, and behavioral abnormalities. According to these reports, signals via N-methyl-D-aspartate receptors (NMDA-r) and/or γ-aminobutyric acid type A receptors (GABAA -r) are implicated in the anesthetic neurotoxicity. On the other hand, during brain development, NMDA-r and GABAA -r are also recognized to play primary roles in neural cell migration...
2018: Biomedical Research
https://www.readbyqxmd.com/read/29433370/vitamin-d-deficiency-in-pregnant-women-and-newborns-in-lagos-nigeria
#19
Emmanuel Owie, Bosede Bukola Afolabi
We aimed to determine the prevalence of Vitamin D deficiency among pregnant women and their newborns in order to make recommendations for Vitamin D supplementation, if necessary. It was a cross-sectional study carried out over a period of 12 months. Information such as use of Vitamin D supplements, number of daytime hours spent outdoors and dressing style was obtained from 166 pregnant women in Lagos, Nigeria; maternal and cord blood 25(OH)D concentration was determined using ELISA. The prevalence of Vitamin D deficiency (<20 ng/mL) in the mothers and newborns was 4...
February 13, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29420746/probiotic-treatment-during-neonatal-age-provides-optimal-protection-against-experimental-asthma-through-the-modulation-of-microbiota-and-t-cells
#20
Caroline Fraga Nunes, Jeane S Nogueira, Pedro Henrique Oliveira Vianna, Bianca Torres Ciambarella, Patrícia Machado Rodrigues, Karla Rodrigues Miranda, Leandro Araújo Lobo, Regina Maria Cavalcanti Pillotto Domingues, Mileane Busch, Georgia Correa Atella, André Macedo Vale, Maria Bellio, Alberto Nóbrega, Fábio B Canto, Rita Fucs
The incidence of allergic diseases, which increased to epidemic proportions in developed countries over the last few decades, has been correlated with altered gut microbiota colonization. Although probiotics may play a critical role in the restoration of gut homeostasis, their efficiency in the control of allergy is controversial. Here, we aimed to investigate the effects of probiotic treatment initiated at neonatal or adult ages on the suppression of experimental ovalbumin (OVA)-induced asthma. Neonatal or adult mice were orally treated with probiotic bacteria and subjected to OVA-induced allergy...
April 3, 2018: International Immunology
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