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Neonatal over exposure

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https://www.readbyqxmd.com/read/29126435/human-amnion-cells-reverse-acute-and-chronic-pulmonary-damage-in-experimental-neonatal-lung-injury
#1
Dandan Zhu, Jean Tan, Amina S Maleken, Ruth Muljadi, Siow T Chan, Sin N Lau, Kirstin Elgass, Bryan Leaw, Joanne Mockler, Daniel Chambers, Kristen T Leeman, Carla F Kim, Euan M Wallace, Rebecca Lim
BACKGROUND: Despite advances in neonatal care, bronchopulmonary dysplasia (BPD) remains a significant contributor to infant mortality and morbidity. While human amnion epithelial cells (hAECs) have shown promise in small and large animal models of BPD, there is scarce information on long-term benefit and clinically relevant questions surrounding administration strategy remain unanswered. In assessing the therapeutic potential of hAECs, we investigated the impact of cell dosage, administration routes and timing of treatment in a pre-clinical model of BPD...
November 10, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29121823/effect-of-tumor-necrosis-factor-alpha-dose-and-exposure-time-on-tumor-necrosis-factor-induced-gene-6-activation-by-neonatal-and-adult-mesenchymal-stromal-cells
#2
Shiva Hamidian Jahromi, Yunqing Li, John E Davies
Tumor necrosis factor (TNF)-stimulated gene 6 (TSG-6) is a major anti-inflammatory mediator released by activated mesenchymal stromal cells (MSCs). Neonatal MSCs are considered more metabolically active than cells derived from adult tissues, and potentially less heterogeneous. We hypothesized that a TNF-α activated neonatal MSC population (human umbilical cord perivascular cells-HUCPVCs) would show an enhanced level of TSG-6 activation compared to adult bone marrow MSCs (BMMSCs). Thus, we stimulated HUCPVCs, and both human and mouse BMMSCs with 1, 10, 50, and 100ng/mL of recombinant TNF-α over various exposure times...
November 9, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/29095430/excipient-exposure-in-very-low-birth-weight-preterm-neonates
#3
T O Akinmboni, N L Davis, A J Falck, C F Bearer, S M Mooney
OBJECTIVE: The excipients benzyl alcohol, propylene glycol and ethanol are present in medications used in the neonatal intensive care unit. Exposure to high levels can have adverse effects in a neonatal population. The objective was to quantify excipient exposure in very low birth weight (VLBW) neonates and identify risk factors associated with greater exposure. STUDY DESIGN: A retrospective record review of VLBW infants admitted over 1 year. Excipient exposures were calculated and multivariable regression analyses identified risk factors for increasing exposure...
November 2, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29093813/a-twenty-four-hour-observational-study-of-hand-hygiene-compliance-among-health-care-workers-in-debre-berhan-referral-hospital-ethiopia
#4
Tufa Kolola, Takele Gezahegn
Background: Hand hygiene (HH) is recognized as the single most effective strategy for preventing health care-associated infections. In developing countries, data on hand hygiene compliance is available only for few health-care facilities. This study aimed to assess hand hygiene compliance among health-care workers in Debre Berhan referral hospital, Ethiopia. Methods: This study employed the WHO hand hygiene observation method. Direct observation of the health care workers (HCWs) was conducted using an observation record form in five different wards...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29029159/impact-evaluation-of-free-delivery-care-on-maternal-health-service-utilisation-and-neonatal-health-in-nepal
#5
Prabhat Lamichhane, Anurag Sharma, Ajay Mahal
Nepal introduced free delivery services for births in public facilities in 2005 in 25 districts with the intervention initially restricted to women with less than two living children and/or women with obstetric complications. After November 2007, eligibility conditions were relaxed to include all women, and the programme was later expanded to cover an additional 50 districts in December 2008. We exploit the phased expansion of the free birth delivery programme to identify its impact on place of delivery, the presence of skilled birth attendants (SBAs) and neonatal mortality using difference-in-difference methods, on data for 4457 live-births reported between 2001 and 2008 from Nepal Demographic and Health Surveys for 2006 and 2011...
December 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28987617/mitigation-of-postnatal-ethanol-induced-neuroinflammation-ameliorates-trace-fear-memory-deficits-in-juvenile-rats
#6
Molly J Goodfellow, Youn Ju Shin, Derick H Lindquist
Impairments in behavior and cognition are common in individuals diagnosed with fetal alcohol spectrum disorders (FASD). In this study, FASD model rats were intragastrically intubated with ethanol (5g/kg/day; 5E), sham-intubated (SI), or maintained as naïve controls (NC) over postnatal days (PD) 4-9. Ethanol exposure during this human third trimester-equivalent period induces persistent impairments in hippocampus-dependent learning and memory. The ability of ibuprofen (IBU), a non-steroidal anti-inflammatory drug, to diminish ethanol-induced neuroinflammation and rescue deficits in hippocampus-dependent trace fear conditioning (TFC) was investigated in 5E rats...
October 5, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28983789/acute-kidney-injury-in-necrotizing-enterocolitis-predicts-mortality
#7
Cory N Criss, David T Selewski, Bipin Sunkara, Joshua S Gish, Lily Hsieh, Jennifer S Mcleod, Jason O Robertson, Niki Matusko, Samir K Gadepalli
BACKGROUND: Morbidity and mortality with necrotizing enterocolitis (NEC) remains a significant challenge. Acute kidney injury (AKI) has been shown to worsen survival in critically ill neonates. To our knowledge, this study is the first to evaluate the prevalence of AKI and its impact on outcomes in neonatal NEC. METHODS: We carried out a single-center retrospective chart review of all neonates treated for NEC between 2003 and 2015 (N = 181). AKI is defined as a rise in serum creatinine (SCr) from a previous trough according to neonatal modified KDIGO criteria (stage 1 = SCr rise 0...
October 5, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28975368/obesogenic-endocrine-disruptors-and-obesity-myths-and-truths
#8
REVIEW
Giovanna Muscogiuri, Luigi Barrea, Daniela Laudisio, Silvia Savastano, Annamaria Colao
Obesogenic endocrine disruptors, also known as obesogens, are chemicals potentially involved in weight gain by altering lipid homeostasis and promoting adipogenesis and lipid accumulation. They included compounds to which human population is exposed over daily life such as pesticides/herbicides, industrial and household products, plastics, detergents and personal care products. The window of life during which the exposure happens could lead to different effects. A critical window is during utero and/or neonatal period in which the obesogens could cause subtle changes in gene expression and tissue organization or blunt other levels of biological organization leading to increased susceptibility to diseases in the adulthood...
October 3, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28970325/sensory-exposure-of-neonates-in-single-room-environments-sense-an-observational-study-of-light
#9
Kobi Best, Fiona Bogossian, Karen New
OBJECTIVES: To measure the internal and external light exposure of incubators and open cots in an Australian single-room configured neonatal unit and compare findings to current recommendations. METHODS: Light meters were placed in the internal and external environment of incubators and open cots within occupied single rooms in a tertiary-level neonatal unit between 15 September and 28 October 2015. Data were recorded in one-second increments over a minimum of 48 hours per room...
September 27, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28957644/effect-of-early-life-geohelminth-infections-on-the-development-of-wheezing-at-5-years-of-age
#10
Philip J Cooper, Martha E Chico, Maritza G Vaca, Carlos A Sandoval, Sofia Loor, Leila Amorim, Laura C Rodrigues, Mauricio L Barreto, David P Strachan
RATIONALE: Exposures to geohelminths during gestation or early childhood may reduce risk of wheezing illness/asthma and atopy during childhood in tropical regions. OBJECTIVES: To investigate the effect of maternal and early childhood geohelminths on development of wheeze/asthma and atopy during the first 5 years of life. METHODS: Cohort of 2,404 neonates followed to 5 years of age in rural District in coastal Ecuador. Data on wheeze collected by questionnaire and atopy measured by allergen skin prick test reactivity to 9 allergens at 5 years...
September 28, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28936111/agile-development-of-a-smartphone-app-for-perinatal-monitoring-in-a-resource-constrained-setting
#11
Boris Martinez, Rachel Hall-Clifford, Enma Coyote, Lisa Stroux, Camilo E Valderrama, Christopher Aaron, Aaron Francis, Cate Hendren, Peter Rohloff, Gari D Clifford
Technology provides the potential to empower frontline healthcare workers with low levels of training and literacy, particularly in low- and middle-income countries. An obvious platform for achieving this aim is the smartphone, a low cost, almost ubiquitous device with good supply chain infrastructure and a general cultural acceptance for its use. In particular, the smartphone offers the opportunity to provide augmented or procedural information through active audiovisual aids to illiterate or untrained users, as described in this article...
2017: Journal of Health Informatics in Developing Countries
https://www.readbyqxmd.com/read/28926834/heme-oxygenase-activity-and-heme-binding-in-a-neonatal-mouse-model
#12
Stephanie Kourula, Joyce Ang, Hui Zhao, Flora Kalish, Peter Vandenabeele, Karl G Sylvester, Ronald J Wong, David K Stevenson
BACKGROUND: Severe hemolytic disease of the newborn leads to the release of pro-oxidative free heme (FH). Heme oxygenase (HO) is primarily responsible for detoxifying FH. OBJECTIVE: To investigate the protective effects of HO in a model of heme overload. METHODS: For in vitro studies, NIH3T3 HO-1-luc cells were incubated with 10, 30, or 60 µM FH or methemalbumin (MHA). HO-1 promoter activity was assessed 3, 6, and 24 h after treatment. Cell survival was indexed by viability assays...
September 20, 2017: Neonatology
https://www.readbyqxmd.com/read/28898950/prenatal-bisphenol-a-exposure-affects-fetal-length-growth-by-maternal-glutathione-transferase-polymorphisms-and-neonatal-exposure-affects-child-volume-growth-by-sex-from-multiregional-prospective-birth-cohort-moceh-study
#13
Yu Min Lee, Yun-Chul Hong, Mina Ha, Yangho Kim, Hyesook Park, Hae Soon Kim, Eun-Hee Ha
We aimed to evaluate the effects of Bisphenol-A (BPA) exposure on fetal/child growth from the fetal period to 72months after birth. The MOCEH study is a prospective birth cohort study in Korea. A total of 788 mother-child pairs in the third trimester and 366 pairs in the neonatal period who completed BPA assessment and fetal/children growth outcomes were included. BPA assessments were conducted twice in the third trimester using maternal urines and the neonatal period using neonatal urines. Fetal femur length was measured with ultrasound, and estimated-fetal-weight was calculated...
January 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28898944/associations-between-urinary-total-arsenic-levels-fetal-development-and-neonatal-birth-outcomes-a-cohort-study-in-taiwan
#14
Kai-Wei Liao, Chia-Huang Chang, Ming-Song Tsai, Ling-Chu Chien, Ming-Yi Chung, I-Fang Mao, Yen-An Tsai, Mei-Lien Chen
BACKGROUND: Arsenic exposure is a global health concern. Several studies have focused on chronic arsenic exposure in adults; however, limited data are available regarding the potential adverse effects of prenatal exposure on fetuses and neonates. OBJECTIVES: To assess which time point maternal arsenic exposure may influence the fetus during pregnancy and birth outcomes. METHODS: In this study, total arsenic concentrations were analyzed in urine samples collected from 130 women with singleton pregnancies (22-45years old) in Taiwan from March to December of 2010...
January 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28894213/ultraviolet-radiation-induced-production-of-nitric-oxide-a-multi-cell-and-multi-donor-analysis
#15
Graham Holliman, Donna Lowe, Howard Cohen, Sarah Felton, Ken Raj
Increasing evidence regarding positive effects of exposure to sunlight has led to suggestions that current advice may be overly weighted in favour of avoidance. UV-A has been reported to lower blood pressure, possibly through nitric oxide (NO) production in skin. Here, we set out to investigate effects of UV-A and solar-simulated radiation on the potential source of dermal NO, the effective doses and wavelengths, the responsiveness of different human skin cells, the magnitude of inter-individual differences and the potential influence of age...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28889270/uranium-and-the-central-nervous-system-what-should-we-learn-from-recent-new-tools-and-findings
#16
Céline Dinocourt
Increasing industrial and military use of uranium has led to environmental pollution, which may result in uranium reaching the brain and causing cerebral dysfunction. A recent literature review has discussed data published over the last 10 years on uranium and its effects on brain function (Dinocourt C, Legrand M, Dublineau I, et al., Toxicology 337:58-71, 2015). New models of uranium exposure during neonatal brain development and the emergence of new technologies (omics and epigenetics) are of value in identifying new specific targets of uranium...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28883097/survival-of-very-preterm-infants-admitted-to-neonatal-care-in-england-2008-2014-time-trends-and-regional-variation
#17
Shalini Santhakumaran, Yevgeniy Statnikov, Daniel Gray, Cheryl Battersby, Deborah Ashby, Neena Modi
OBJECTIVE: To analyse survival trends and regional variation for very preterm infants admitted to neonatal care. SETTING: All neonatal units in England. PATIENTS: Infants born at 22(+0)-31(+6) weeks(+days)gestational age (GA) over 2008-2014 and admitted to neonatal care; published data for admitted infants 22(+0)-25(+6) weeks(+days) GA in 1995 and 2006, and for live births at 22(+0)-31(+6) weeks(+days) GA in 2013. METHODS: We obtained data from the National Neonatal Research Database...
September 7, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28880894/in-ovo-and-dietary-administration-of-oligosaccharides-extracted-from-palm-kernel-cake-influence-general-health-of-pre-and-neonatal-broiler-chicks
#18
Mohammad Faseleh Jahromi, Parisa Shokryazdan, Zulkifli Idrus, Rohollah Ebrahimi, Juan Boo Liang
Palm kernel cake (PKC) is the main byproduct from the palm oil industry in several tropical countries that contains considerable amounts of oligosaccharide. We earlier demonstrated beneficial prebiotic effects of oligosaccharides extract of PKC (OligoPKC) in starter and finisher broiler birds. This study was envisaged to elucidate the effects of in ovo and/or oral administration of the OligoPKC on prenatal and post-hatched broiler chicks. A total of 140 broiler (Cobb500) eggs were randomly divided into two groups (n = 70 each), and on day 12 of incubation, eggs in one group received in ovo injection of 0...
2017: PloS One
https://www.readbyqxmd.com/read/28799968/core-temperature-monitoring-in-obstetric-spinal-anesthesia-using-an-ingestible-telemetric-sensor
#19
Leon du Toit, Dominique van Dyk, Ross Hofmeyr, Carl J Lombard, Robert A Dyer
BACKGROUND: Perioperative hypothermia may affect maternal and neonatal outcomes after obstetric spinal anesthesia. Core temperature is often poorly monitored during spinal anesthesia, due to the lack of an accurate noninvasive core temperature monitor. The aim of this study was to describe core temperature changes and temperature recovery during spinal anesthesia for elective cesarean delivery. We expected that obstetric spinal anesthesia would be associated with a clinically relevant thermoregulatory insult (core temperature decrease >1...
August 9, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28791666/clinical-pharmacokinetics-and-pharmacodynamics-of-micafungin
#20
REVIEW
Roeland E Wasmann, Eline W Muilwijk, David M Burger, Paul E Verweij, Catherijne A Knibbe, Roger J Brüggemann
Micafungin is a selective inhibitor of the synthesis of fungal 1,3-β-D-glucan, an essential component of the fungal cell wall. It is available as a powder for infusion only and is registered for the treatment of invasive and esophageal candidiasis in addition to prophylaxis of Candida infections in both adults and children. Average exposure after a single intravenous 100 mg dose in healthy adults is 133 mg h/L. Both exposure and maximum plasma concentration show linear dose proportional pharmacokinetics (PK) over a 0...
August 8, 2017: Clinical Pharmacokinetics
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