Jozine M Ter Maaten, Alexandre Mebazaa, Beth Davison, Christopher Edwards, Marianna Adamo, Mattia Arrigo, Marianela Barros, Jan Biegus, Jelena Čelutkienė, Kamilė Čerlinskaitė-Bajorė, Ovidiu Chioncel, Alain Cohen-Solal, Albertino Damasceno, Rafael Diaz, Gerasimos Filippatos, Etienne Gayat, Antoine Kimmoun, Carolyn S P Lam, Valentine Leopold, Maria Novosadova, Matteo Pagnesi, Peter S Pang, Piotr Ponikowski, Hadiza Saidu, Karen Sliwa, Koji Takagi, Daniela Tomasoni, Marco Metra, Gad Cotter, Adriaan A Voors
AIM: In this subgroup analysis of STRONG-HF, we explored the association between changes in renal function and efficacy of rapid up-titration of guideline-directed medical therapy (GDMT) according to a high-intensity care (HIC) strategy. METHODS AND RESULTS: In patients randomized to the HIC arm (n = 542), renal function was assessed at baseline and during follow-up visits. We studied the association with clinical characteristics and outcomes of a decrease in estimated glomerular filtration rate (eGFR) at week 1, defined as ≥15% decrease from baseline...
December 2023: European Journal of Heart Failure