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CSII, CGMS,

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https://www.readbyqxmd.com/read/27506420/diabetes-induction-by-total-pancreatectomy-in-minipigs-with-simultaneous-splenectomy-a-feasible-approach-for-advanced-diabetes-research
#1
Sophie Heinke, Barbara Ludwig, Undine Schubert, Janine Schmid, Thomas Kiss, Anja Steffen, Stefan Bornstein, Stefan Ludwig
BACKGROUND: Safe and reliable diabetes models are a key prerequisite for advanced preclinical studies on diabetes. Chemical induction is the standard model of diabetes in rodents and also widely used in large animal models of non-human primates and minipigs. However, uncertain efficacy, the potential of beta-cell regeneration, and relevant side effects are debatable aspects particularly in large animals. Therefore, we aimed to evaluate a surgical approach of total pancreatectomy combined with splenectomy for diabetes induction in an exploratory study in Goettingen minipigs...
September 2016: Xenotransplantation
https://www.readbyqxmd.com/read/26798658/comparison-of-the-effects-of-continuous-subcutaneous-insulin-infusion-and-add-on-therapy-with-sitagliptin-in-patients-with-newly-diagnosed-type-2-diabetes-mellitus
#2
Heng Wan, Defu Zhao, Jie Shen, Lu Lu, Tong Zhang, Zhi Chen
To identify a new regimen to optimize treatment for patients with newly diagnosed type 2 diabetes (T2DM) by short-term continuous subcutaneous insulin infusion (CSII) alone. Methods. 60 patients with newly diagnosed T2DM were randomized into two groups (n = 30 each) and treated for 2 weeks with CSII alone (CSII group) or with CSII plus sitagliptin (CSII + Sig group). The glycemic variability of the patients was measured using a continuous glucose monitoring system (CGMS) for the last 72 hours. A standard meal test was performed before and after the interventions, and the levels of glycated albumin, fasting glucose, fasting C-peptide, postprandial 2 h blood glucose, and postprandial 2 h C-peptide were examined...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/26640487/influence-of-acarbose-on-plasma-glucose-fluctuations-in-insulin-treated-patients-with-type-2-diabetes-a-pilot-study
#3
Feng-Fei Li, Xiao-Hua Xu, Li-Yuan Fu, Xiao-Fei Su, Jin-Dan Wu, Chun-Feng Lu, Lei Ye, Jian-Hua Ma
Background and Aims. To evaluate the effect of adding acarbose on glycemic excursions measured by continuous glucose monitoring system (CGMS) in patients with type 2 diabetes mellitus (T2DM) already on insulin therapy. Materials and Methods. This was an opened and unblended study. 134 patients with T2DM were recruited. After initial rapidly corrected hyperglycaemia by continuous subcutaneous insulin infusion (CSII) for 7 d, a 4-6-day premixed insulin titration period subsequently followed. Patients were then randomized 1 : 1 to acarbose plus insulin group or insulin therapy group for 2 weeks...
2015: International Journal of Endocrinology
https://www.readbyqxmd.com/read/26004196/diabetes-in-pregnancy
#4
REVIEW
David R McCance
Diabetes in pregnancy is still considered a high-risk condition for both mother and baby. Even in the best centres, malformation and mortality rates are reportedly twofold to fivefold higher than in the background population, and pregnancy planning rates remain obstinately poor. Increasing global rates of type 2 diabetes are now extending into pregnancy, with similarly poor outcomes to type 1 diabetes, and excess maternal weight is adding to the complexity of management. Over the last 5-10 years, several randomised trials have offered new insight into the role of oral hypoglycaemic drugs and insulin analogues in pregnancy, while continuous subcutaneous insulin infusion (CSII) pumps and continuous glucose monitors (CGMs) are under scrutiny...
July 2015: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/25643603/a-novel-tool-to-predict-youth-who-will-show-recommended-usage-of-diabetes-technologies
#5
Orla M Neylon, Timothy C Skinner, Michele A O'Connell, Fergus J Cameron
BACKGROUND AND OBJECTIVE: Controversy exists regarding which individuals will benefit most from commencement of diabetes technologies such as continuous subcutaneous insulin infusion (CSII) or continuous glucose monitoring systems (CGMS), such as 'real-time' sensor-augmented pumping (SAP). Because higher usage correlates with haemoglobin A1c (HbA1c) achieved, we aimed to predict future usage of technologies using a questionnaire-based tool. SUBJECTS: The tool was distributed to two groups of youth with type 1 diabetes; group A (n = 50; mean age 12 ± 2...
May 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/24351182/description-and-preliminary-evaluation-of-a-diabetes-technology-simulation-course
#6
Rebecca D Wilson, Marilyn Bailey, Mary E Boyle, Karen M Seifert, Karla Y Cortez, Leslie J Baker, Michael J Hovan, Jan Stepanek, Curtiss B Cook
BACKGROUND: We aim to provide data on a diabetes technology simulation course (DTSC) that instructs internal medicine residents in the use of continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring system (CGMS) devices. METHODS: The DTSC was implemented during calendar year 2012 and conducted in the institution's simulation center. It consisted of a set of prerequisites, a practicum, and completion of a web-based inpatient CSII-ordering simulation...
November 2013: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/24229667/correlation-between-blood-glucose-fluctuations-and-activation-of-oxidative-stress-in-type-1-diabetic-children-during-the-acute-metabolic-disturbance-period
#7
Di Wu, Chun-Xiu Gong, Xi Meng, Qiu-Lan Yang
BACKGROUND: Studies have shown that complications in type 1 diabetes mellitus (T1DM) in children are mainly due to oxidative stress (OS). Lipid peroxidation is the main marker of OS and iso-prostaglandin is a reliable biomarker of lipid peroxidation in type 2 diabetes mellitus (T2DM). However, there have been few studies on OS in T1DM children with hyperglycemia and glucose fluctuations. METHODS: We prospectively enrolled 23 newly diagnosed T1DM patients and 23 age and sex matched healthy controls in Beijing Children's Hospital from May 2010 to January 2011...
November 2013: Chinese Medical Journal
https://www.readbyqxmd.com/read/21211306/-prediction-of-nocturnal-hypoglycaemia-with-bedtime-glucose-level-during-continuous-subcutaneous-insulin-infusion-in-type-2-diabetics
#8
Ming Li, Jian Zhou, Yu-qian Bao, Wei Lu, Wei-ping Jia
OBJECTIVE: To find out the features of glycemic excursion via continuous glucose monitoring system (CGMS) during continuous subcutaneous insulin infusion (CSII) treatment in type 2 diabetics and discuss the possibility of predicting nocturnal hypoglycaemia with bedtime glucose level. METHODS: A total of 257 diabetes patients (156 males and 101 females, aged from 27 - 88 years old) with 0.1 - 40 years diabetic history were recruited. Their HbA1c level was (10.97 ± 2...
November 16, 2010: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/21062674/the-impact-of-continuous-subcutaneous-insulin-infusion-and-multiple-daily-injections-of-insulin-on-glucose-variability-in-older-adults-with-type-2-diabetes
#9
RANDOMIZED CONTROLLED TRIAL
Susan L Johnson, Laura N McEwen, Christopher A Newton, Catherine L Martin, Philip Raskin, Jeffrey B Halter, William H Herman
AIMS: To determine whether continuous subcutaneous insulin infusion (CSII) or multiple daily injections of insulin (MDI) are associated with improved glycemic variability. METHODS: Type 2 diabetic patients ≥60 years of age were randomized to 12 months of CSII (n=53) or MDI (n=54) therapy. Patients were asked to complete monthly eight-point self-monitored glucose profiles (n=78) and continuous glucose monitoring systems (CGMS) for up to 72 h at Months 0, 6, and 12 (n=77)...
July 2011: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/20687863/basal-insulin-substitution-with-glargine-or-continuous-subcutaneous-insulin-infusion-in-adult-type-1-diabetes-patients-a-randomized-controlled-trial
#10
RANDOMIZED CONTROLLED TRIAL
Joakim Bragd, Anna von Döbeln, Per-Eric Lins, Ulf Adamson, Jakob Bergström, Per Oskarsson
BACKGROUND: It is generally held that basal insulin substitution with continuous subcutaneous insulin infusion (CSII) provides less variable glucose levels than with long-acting insulin analogs, e.g., glargine, in patients with type 1 diabetes, although this has not been convincingly demonstrated by continuous glucose monitoring. METHODS: To compare glucose control assessed by a continuous glucose monitoring system (CGMS) during basal insulin substitution with glargine versus CSII, we conducted a non-blinded, randomized, crossover trial in 15 type 1 diabetes patients experienced with CSII...
September 2010: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/19629931/benefits-of-continuous-subcutaneous-insulin-infusion-in-type-1-diabetes-previously-treated-with-multiple-daily-injections-with-once-daily-glargine-and-pre-meal-analogues
#11
I Torres, J Ortego, I Valencia, M V García-Palacios, M Aguilar-Diosdado
BACKGROUND/AIMS: There is insufficient information about the use of continuous subcutaneous insulin infusion (CSII) versus multiple daily injections (MDI) using long-acting insulin analogs in relation to possible metabolic consequences and, as well, on the grade of patient satisfaction. The aim of the study was to evaluate the usefulness of CSII treatment in patients with type 1 diabetes in achieving glycemic objectives using continuous glucose monitoring system (CGMS) and in improving patient's satisfaction with treatment...
September 2009: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/19166434/a-comparison-of-glycaemic-variability-in-csii-vs-mdi-treated-type-1-diabetic-patients-using-cgms
#12
COMPARATIVE STUDY
B Simon, V Treat, C Marco, D Rosenberg, J Joseph, B Hipszer, Y Li, I Chervoneva, L Padron-Massara, S Jabbour
OBJECTIVE: To evaluate and compare glucose variability, hypoglycaemic events and daily glycaemic control in well-controlled (HbA1c <or= 7%), type 1 diabetic patients treated with either continuous subcutaneous insulin infusion (CSII) using lispro or multiple daily insulin injection (MDI) using glargine once daily and lispro with meals. RESEARCH DESIGN AND METHODS: A total of 16 patients with type 1 diabetes receiving treatment with either CSII (eight patients) or MDI (eight patients), all with HbA1c levels < 7%, wore a continuous glucose monitoring system sensor for 3 days to compare the number, duration, timing and severity of hyperglycaemic and hypoglycaemic episodes...
December 2008: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/19024537/-evaluating-the-feature-of-hypoglycemia-detected-by-continuous-glucose-monitoring-system-during-temporary-continuous-subcutaneous-insulin-infusion-in-type-2-diabetes-patients
#13
Ming Li, Jian Zhou, Yu-qian Bo, Wei Lu, Wei-ping Jia, Kun-san Xiang
OBJECTIVE: To use continuous glucose monitoring system (CGMS) to investigate the features of hypoglycemia in control of hyperglycemia in T2DM patients by continuous subcutaneous insulin infusion (CSII) and to study the influencing factors of hypoglycemia. METHODS: Sixty-one T2DM patients, 35 males and 26 females, age 23-88, with the disease duration of 0.5-12 years, HbA1c level of (11.1 +/- 1.6)%, and glycosylated serum protein of (32 +/- 6)%, underwent. CSII and finger blood sugar test...
June 24, 2008: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/18831908/clinical-usefulness-of-a-bolus-calculator-in-maintaining-normoglycaemia-in-active-professional-patients-with-type-1-diabetes-treated-with-continuous-subcutaneous-insulin-infusion
#14
T Klupa, T Benbenek-Klupa, M Malecki, M Szalecki, J Sieradzki
This observational study assessed metabolic control in young, active professionals with type 1 diabetes treated with continuous subcutaneous insulin infusion (CSII) with or without the use of a bolus calculator. Eighteen patients aged 19 - 51 years with diabetes duration of 6 - 22 years were included; eight patients used a bolus calculator and 10 did not. Metabolic control was assessed by glycosylated haemoglobin (Hb(A1c)) measurements and blood glucose profiles. A continuous glucose monitoring system (CGMS) was also used by three patients from each group...
September 2008: Journal of International Medical Research
https://www.readbyqxmd.com/read/18034605/restoring-euglycemia-in-the-basal-state-using-continuous-glucose-monitoring-in-subjects-with-type-1-diabetes-mellitus
#15
Howard C Zisser, Wendy C Bevier, Lois Jovanovic
BACKGROUND: Our objective was to use continuous glucose monitoring to derive the optimal basal insulin infusion rates in adults with type 1 diabetes and using continuous subcutaneous insulin infusion (CSII) pumps. METHODS: In an effort to mimic euglycemia during the basal state, we used a standard protocol to adjust basal insulin infusion rates in 16 subjects with type 1 diabetes mellitus who were using CSII pumps. All subjects wore Continuous Glucose Monitoring System sensors (CGMS), Medtronic Minimed, Northridge, CA) in order to obtain around-the-clock tracings of their glucose measurements...
December 2007: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/17357293/safety-of-various-methods-of-intensive-insulin-therapy-in-hospital-condition-assessed-by-hypoglycaemic-episodes-detected-with-the-use-of-continuous-glucose-monitoring-system
#16
RANDOMIZED CONTROLLED TRIAL
M Mozdzan, J Ruxer, J Loba, A Siejka, L Markuszewski
PURPOSE: The aim of the study was to determine the safety of three intensive insulin therapy methods: multiple daily insulin injections (MDI), continuous subcutaneous insulin infusion (CSII) and continuous intravenous insulin infusion (IVII) used in poorly controlled type 2 diabetic patients in hospital condition. The safety of these intensive insulin therapy methods was measured by the assessment of number and duration of symptomatic and symptomfree hypoglycaemic events with use of Continuous Glucose Monitoring System (CGMS, Medtronic MiniMed)...
2006: Advances in Medical Sciences
https://www.readbyqxmd.com/read/16978378/performance-of-the-continuous-glucose-monitoring-system-cgms-during-development-of-ketosis-in-patients-on-insulin-pump-therapy
#17
J Pfützner, T Forst, R Butzer, S Forst, M M Weber, A H Pfützner, A Pfützner
AIMS: Ketoacidosis is one of the most severe complications of Type 1 diabetes. Development of ketosis leads to substantial shifts in electrolyte and ion concentrations in the different fluid compartments of the body. This study was performed to investigate the performance of the continuous glucose monitoring device (CGMS) during ketoacidosis. METHODS: Twelve patients with Type 1 diabetes using continuous subcutaneous insulin infusion (CSII) participated in this trial [10 women, two men; age (mean +/- sd) 34 +/- 9 years; disease duration 17 +/- 10 years; HbA(1c) 7...
October 2006: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/16801571/continuous-glucose-monitoring-guided-insulin-adjustment-in-children-and-adolescents-on-near-physiological-insulin-regimens-a-randomized-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Kylie Yates, Abul Hasnat Milton, Keith Dear, Geoffrey Ambler
OBJECTIVE: This randomized controlled trial assesses the effect on glycemic control of continuous glucose monitoring system (CGMS)-guided insulin therapy adjustment in young people with type 1 diabetes on intensive diabetes treatment regimens with continuous subcutaneous insulin infusion (CSII) or glargine. RESEARCH DESIGN AND METHODS: Pediatric subjects were recruited if they had an HbA(1c) (A1C) <10% and had been on CSII or glargine for at least 3 months. Thirty-six subjects were randomized to insulin adjustment on the basis of 72 h of CGMS every 3 weeks or intermittent self-monitoring of blood glucose (SMBG) for 3 months...
July 2006: Diabetes Care
https://www.readbyqxmd.com/read/16386093/insulin-pump-therapy-in-preschool-children-with-type-1-diabetes-mellitus-improves-glycemic-control-and-decreases-glucose-excursions-and-the-risk-of-hypoglycemia
#19
COMPARATIVE STUDY
George S Jeha, Lefkothea P Karaviti, Barbara Anderson, E O'Brian Smith, Susan Donaldson, Toniean S McGirk, Morey W Haymond
BACKGROUND: Hypoglycemia in preschool children limits the effectiveness of insulin therapy. Continuous subcutaneous insulin infusion (CSII) is not widely used in this group. OBJECTIVES: This study was designed (1) to test the hypothesis that compared with twice-daily insulin injection, CSII decreases the SD of the mean daily blood glucose (BG) and improves glycemic control and (2) to evaluate the effect of CSII on parental anxiety using the Parental Stress Index (PSI) scale...
December 2005: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/16120030/continuous-subcutaneous-insulin-infusion-and-multiple-dose-of-insulin-regimen-display-similar-patterns-of-blood-glucose-excursions-in-pediatric-type-1-diabetes
#20
Ramin Alemzadeh, Paola Palma-Sisto, E A Parton, M K Holzum
BACKGROUND: Continuous subcutaneous insulin infusion (CSII) is believed to decrease glycemic variability and clinical hypoglycemia compared with the multiple daily insulin (MDI) regimen. To compare the indices of glycemic instability between CSII and MDI, we analyzed the continuous glucose monitoring system (CGMS) (Medtronic MiniMed, Northridge, CA) profiles of a group of children with type 1 diabetes mellitus with history of frequent blood glucose (BG) fluctuations and hypoglycemia. PATIENTS AND METHODS: Data from 14 (nine girls, five boys) patients (3...
August 2005: Diabetes Technology & Therapeutics
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